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1. LA GENESE DU PROGRAMME UNIONISTE : « LA SOCIÉTÉ DE L’UNION » DE YASSY (1856)

Author

Dumitru VITCU

Subjects
les principautés roumaines, le congrès de paris (1856), « la société de l’union » de yassy, m. kogălniceanu, v. alecsandri, c. negri, c. hurmuzachi, v. mălinescu, des divans ad-hoc, la convention de paris (1858), History (General), D1-2009
Abstract

Dans le processus ample et complexe de la lutte pour l’achèvement de l’État national roumain moderne, l’ancienne capitale de Moldavie (la ville de Yassy) a joué un rôle décisif, signalé pour la première fois par le grand historien A. D. Xenopol. Un aspect significatif et en même temps un argument dans ce sens sont offerts par ce texte consacré à l’organisation de la lutte pour l’unité nationale dans les Principautés Roumaines, immédiatement après la clôture du Congrès de Paris (1856), qui pacifiait pour une période l’éternelle « question orientale ». Mais, ce que le conclave diplomatique européen n’a pas réussi – l’unité nationale roumaine – allait être achevé par les Roumains même, tout en affirmant clairement les droits et les objectifs nationaux, ainsi que les moyens de leur accomplissement. Le fondement de tout effort patriotique a été représenté à ce momentlà par « la Société de l’Union » de Yassy, organisée le 25 mai 1856 et composée des leaders unionistes moldaves : M. Kogălniceanu, V. Alecsandri, C. Negri, C. Hurmuzachi, V. Mălinescu etc., qui ont formulé et distribué, dans l’espace roumain extra-carpatique entier, les lignes directrices du programme national. Les deux Assemblées consultatives (des Divans ad-hoc) de Bucarest et Yassy les ont reprises et appropriées en intégralité pour les transmettre ultérieurement aux Puissances européennes garantes, qui ont élaboré – sur leur base – l’éphémère Constitution pour les Principautés Unies, la Convention de Paris (1858).

Published
2022
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2. Post-Severe-COVID-19 Cardiopulmonary Rehabilitation: A Comprehensive Study on Patient Features and Recovery Dynamics in Correlation with Workout Intensity

Author

Andreea Dumitrescu, Gabriela Doros, Voichita Elena Lazureanu, Susa Septimiu-Radu, Felix Bratosin, Ovidiu Rosca, Harshkumar Patel, Tamara Mirela Porosnicu, Gabriela Mut Vitcu, Andrei Mirea, Cristian Oancea, Stefan Mihaicuta, Emil Robert Stoicescu, and Paula Irina Barata

Subjects
COVID-19, SARS-CoV-2, post acute COVID-19 syndrome, cardiopulmonary rehabilitation, Medicine
Abstract

The aftermath of severe COVID-19 frequently involves considerable cardiopulmonary damage, necessitating rehabilitation. This study aimed to evaluate the impact of COVID-19 on cardiopulmonary health and assess the effectiveness of various rehabilitative interventions. Conducted between September 2021 and September 2022, this prospective study included patients who had been diagnosed with severe COVID-19 and admitted at the “Victor Babes” Infectious Diseases and Pulmonology Hospital, Timisoara, Romania. The patients were stratified into low- and high-intensity rehabilitation groups. The rehabilitation protocols were individually tailored, and the patient recovery was closely monitored over a 3-month period. Our cohort comprised 84 patients, with a mean age of 56.3 years for the low-intensity group (n = 42) and 53.1 years for the high-intensity group (n = 42). Both groups showed significant improvements in the lung injury area, need for oxygen supplementation, ejection fraction, systolic pulmonary artery pressure, and forced vital capacity. Additionally, considerable enhancements were observed in maximal voluntary ventilation, FEV1, FEV1/FVC ratio, peak expiratory flow, and forced expiratory flow at 25–75%. The work intensity also demonstrated substantial improvements from the initial testing to the 3-month mark in both groups. This study provides evidence that personalized, targeted rehabilitation strategies can improve long-term cardiopulmonary health in patients recovering from severe COVID-19, proving both low-intensity and high-intensity training as sufficient to improve heart and lung function if performed correctly and over a relatively short duration of 3 months. The study findings underscore the importance of implementing comprehensive cardiopulmonary rehabilitation protocols in the care of post-COVID-19 patients and highlight the value of stratified rehabilitation intensity based on individual patient dynamics and recovery features.

Published
2023
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3. Post-Severe-COVID-19 Cardiopulmonary Rehabilitation: A Comprehensive Study on Patient Features and Recovery Dynamics in Correlation with Workout Intensity

Author

Dumitrescu, Andreea, primary, Doros, Gabriela, additional, Lazureanu, Voichita Elena, additional, Septimiu-Radu, Susa, additional, Bratosin, Felix, additional, Rosca, Ovidiu, additional, Patel, Harshkumar, additional, Porosnicu, Tamara Mirela, additional, Vitcu, Gabriela Mut, additional, Mirea, Andrei, additional, Oancea, Cristian, additional, Mihaicuta, Stefan, additional, Stoicescu, Emil Robert, additional, and Barata, Paula Irina, additional

Published
2023
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4. Post-Severe-COVID-19 Cardiopulmonary Rehabilitation: A Comprehensive Study on Patient Features and Recovery Dynamics in Correlation with Workout Intensity

Author

Barata, Andreea Dumitrescu, Gabriela Doros, Voichita Elena Lazureanu, Susa Septimiu-Radu, Felix Bratosin, Ovidiu Rosca, Harshkumar Patel, Tamara Mirela Porosnicu, Gabriela Mut Vitcu, Andrei Mirea, Cristian Oancea, Stefan Mihaicuta, Emil Robert Stoicescu, and Paula Irina

Subjects
COVID-19, SARS-CoV-2, post acute COVID-19 syndrome, cardiopulmonary rehabilitation
Abstract

The aftermath of severe COVID-19 frequently involves considerable cardiopulmonary damage, necessitating rehabilitation. This study aimed to evaluate the impact of COVID-19 on cardiopulmonary health and assess the effectiveness of various rehabilitative interventions. Conducted between September 2021 and September 2022, this prospective study included patients who had been diagnosed with severe COVID-19 and admitted at the “Victor Babes” Infectious Diseases and Pulmonology Hospital, Timisoara, Romania. The patients were stratified into low- and high-intensity rehabilitation groups. The rehabilitation protocols were individually tailored, and the patient recovery was closely monitored over a 3-month period. Our cohort comprised 84 patients, with a mean age of 56.3 years for the low-intensity group (n = 42) and 53.1 years for the high-intensity group (n = 42). Both groups showed significant improvements in the lung injury area, need for oxygen supplementation, ejection fraction, systolic pulmonary artery pressure, and forced vital capacity. Additionally, considerable enhancements were observed in maximal voluntary ventilation, FEV1, FEV1/FVC ratio, peak expiratory flow, and forced expiratory flow at 25–75%. The work intensity also demonstrated substantial improvements from the initial testing to the 3-month mark in both groups. This study provides evidence that personalized, targeted rehabilitation strategies can improve long-term cardiopulmonary health in patients recovering from severe COVID-19, proving both low-intensity and high-intensity training as sufficient to improve heart and lung function if performed correctly and over a relatively short duration of 3 months. The study findings underscore the importance of implementing comprehensive cardiopulmonary rehabilitation protocols in the care of post-COVID-19 patients and highlight the value of stratified rehabilitation intensity based on individual patient dynamics and recovery features.

Published
2023
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5. Depression influences the quality of diabetes-related self-management activities in elderly patients with type 2 diabetes: a cross-sectional study

Author

Mut-Vitcu G, Timar B, Timar R, Oancea C, and Citu IC

Subjects
Diabetes, Depression, Self-care, Quality of life, Geriatrics, RC952-954.6
Abstract

Gabriela Mut-Vitcu,1 Bogdan Timar,2 Romulus Timar,1 Cristian Oancea,3 Ioan Cosmin Citu4 1Second Department of Internal Medicine, 2Department of Functional Sciences, 3Department of Infectious Diseases, 4Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania Purpose: To evaluate the prevalence of depression and its impact on the quality of diabetes-related self-care activities in elderly patients with type 2 diabetes. Patients and methods: In this cross-sectional study, 184 patients with type 2 diabetes were enrolled. Depression was evaluated using Patient Health Questionnaire-9 while the quality of diabetes-related self-care activities was assessed using the Summary of Diabetes-Related Self Care Activities Questionnaire. Results: In our study group, 53.3% of the patients had moderate depression, 17.9% had severe depression, and 28.8% had no depression symptoms. Patient’s age (P=0.024), presence of diabetic neuropathy (P

Published
2016

6. 'La question juive' dans les relations externes de la Roumanie à la fin du XIX-ème siècle

Author

Dumitru Vitcu

Subjects
La Roumanie, la politique externe, les Juifs, les minorités ethniques, l’Alliance Israélite Universelle, la diplomatie, la discrimination ethnique, le gouvernement roumain, le secrétaire d’Etat, le ministre des Affaires Etrangères, History (General), D1-2009
Abstract

The first Romanian modern Constitution of 1866 generated – by its restrictive character towards the political and civil rights of the non-Christian citizens in the country – a problem more and more complicated for the governmental circles from Bucharest and for Romanian diplomacy, too. The development of the so called „Jewish question” from an internal economic and social problem into a external political one was produced at the initiative and with large support of the World Jewish Alliance (founded in Paris in 1860). Together with the American Independent Order „B’nai B’rith”, the two organizations succeded to initiate and develop, by various means, a strong diplomatic pressure against Romania, in order to require her to respect proper obligations assumed by the decisions of the Congress of Berlin in 1878. The beginning of that pressure was marked by the American diplomats, either from Constantinopol, Bucharest or Washington D.C., and increased constantly up to the first decade of the XX-th Century. Otherwise, all the diplomatic and economic relations between the United States of America and Romania, since 1866 up to the end of the First World War, were dependent by the attitude of the decisional political factors from Bucharest on the Jewish question. The situation did not improve with the coming of the new Century, and in fact worsened. To the reasons already existing for the low level of bilateral relations, another aggravating element of economic and social nature was added, but dressed in strident political terms.The Jewish question was again revitalized, fostered by immigration to America, with its maximum intensity situated around the turn of the century, when the American authorities reacted in a manner and used means rejected by the Romanian political class and which were not shared by the majority of European powers. The cause was a diplomatic Appeal launched in 1902 by the American Secretary of State, John Hay, seeking to revitalise a diplomatic pressure against Romania, a gesture proved later to be inopportune and insincere on the part of its initiator. Fortunately, the unfavorable effects of the Romanian-American diplomatic incident of 1902, the motivation for which (real or supposed) underlined the primordial place or role of the Jewish question in the ensemble of relations between the two countries, were overcome by a better understanding in Washington of the political realities in the region and certainly through the efforts of its diplomatic representatives accredited in Romania.

Published
2009

12. High-resolution tunable mid-infrare spectrometer d based on difference-frequency generation in AgGa[S.sub.2]

Author

Vitcu, Adrian, Ciurylo, Richard, Wehr, Roman, Drummond, James R., and May, A. David

Subjects
Greenhouse gases -- Measurement, Optical spectrometers, Astronomy, Physics
Abstract

We have built a high-resolution and high-signal-to-noise ratio spectrometer for line shape studies of greenhouse gases in the mid infrared. The infrared radiation is generated in a AgGa[S.sub.2] nonlinear crystal by the well-known difference-frequency method. The choice of crystal is explained, and a brief literature review is presented. With two tunable dye lasers and a type I, 90[degrees] phase-matching geometry, the infrared is continuously tunable from 7 to 9 [micro]m when Rhodamine 6G and Sulforhodamine 640 dyes are used. The total infrared power exceeds 30 nW and is limited by both the damage threshold and thermal loading of the crystal. Phase-sensitive detection allows us to reach signal-to-noise ratios in excess of 3500:1 while maintaining an instrumental linewidth of 1.5 MHz. However, we show that the spectrometer may be used to measure the positions of spectral lines within [+ or -] 400 kHz. OCIS codes: 300.6190, 300.6340, 120.6200, 160.4330, 190.2620, 190.4400.

Published
2004

13. Dynamic spectroscopic measurements of the temperature and pressure cycles in a MOPITT pressure modulator cell

Author

Wehr, Richard, McKernan, Eamonn, Vitcu, Adrian, Ciurylo, Roman, and Drummond, James R.

Subjects
Spectroscope -- Research, Astronomy, Physics
Abstract

The temperature and pressure cycles inside a pressure modulator cell (PMC) of the type used for gas-correlation radiometry aboard the Measurements of Pollution in the Troposphere (MOPITT) satellite instrument have been determined from dynamic measurements of the spectral line shapes of the R(0) and R(18) transitions in the fundamental vibrational--rotational band of carbon monoxide. The line strengths and linewidths were used to calculate the temperature and pressure, respectively, with a temporal resolution of approximately 200 [micro]s, or 1/100 of a PMC cycle. The results are compared with a thermodynamic box model. OCIS codes: 120.0280, 300.6340, 020.3690, 120.5630, 300.6360, 280.1120.

Published
2003

17. Body Mass Index and Glycaemic Control in Patients with Diabetes Mellitus: A Case-Control Study

Author

Iuliana-Claudia Hudrea, Laura Gaiţă, Gabriela Mut-Vitcu, Svetlana Mosteoru, and Dan Gaiţă

Subjects
medicine.medical_specialty, endocrine system diseases, business.industry, Case-control study, nutritional and metabolic diseases, Specialties of internal medicine, 030209 endocrinology & metabolism, body mass index, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, RC581-951, Diabetes mellitus, Internal medicine, diabetes mellitus, Endocrinology diabetology, glycemic control, Medicine, In patient, 030212 general & internal medicine, business, Body mass index
Abstract

Background and Aims: Recent studies have brought evidence on the connection between excess weight and suboptimal glycemic control for Diabetes Mellitus (DM) patients. The aim of this study was to evaluate the association between increased Body Mass Index (BMI) and the likelihood of having suboptimal glycemic control in patients with Type 1 and Type 2 Diabetes Mellitus. Materials and Methods: A case-control study was conducted on 662 patients suffering from Diabetes Mellitus and statistical analysis was performed in order obtain evidence associating BMI and poor glycaemic control. We defined as increased BMI, values >25 kg/m2 and a hemoglobin A1c (HbA1c) value >7% reflected suboptimal glycemic control. Results: 559 (84%) patients had HbA1c >7%. 550 (83 %) patients had a BMI >25 kg/m2. In case of HbA1c >7%, a BMI >25 kg/m2 was found in a number of 457 patients (82 %), whereas a normal BMI was present in 102 (18%) patients. For the HbA1c25 kg/m2 was 93 (90%) and a normal BMI was present in 10 (10%) patients. BMI >25 kg/m2 was not associated with a higher probability of having above-target HbA1c values compared to patients with target HbA1c (OR 0.48, 95% CI: 0.24 to 0.95), with a statistically significant p 25 kg/m2 was significantly higher than the number of patients with a BMI < 25 kg/m2, a BMI above target was not associated with greater odds of having HbA1c higher than the standard 7% level, compared to individuals with normal HbA1c levels. The results emphasize that a multitude of factors are involved in the process of achieving a targeted glycemic control and a stepped-care approach should be considered for optimum management of Diabetes Mellitus.

Published
2017

21. Management and outcome of patients with established coronary artery disease: the Euro Heart Survey on coronary revascularization

Author

Lenzen, M. J., Boersma, E., Bertrand, M. E., Maier, W., Moris, C., Piscione, F., Sechtem, U., Stahle, E., Widimsky, P., De Jaegere, P., Scholte Op Reimer, W. J. M., Mercado, N., Wijns, W., Meier, B., Sergeant, P., Vos, J., Unger, F., Manini, Malika, Bramley, Claire, Laforest, Valérie, Taylor, Charles, Del Gaiso, Susan, Huber, Kurt, De Backer, Guy, Sirakova, Vera, Cerbak, Roman, Thayssen, Per, Lehto, Seppo, Blanc, Jean-Jacques, Delahaye, François, Kobulia, Bondo, Zeymer, Uwe, Cokkinos, Dennis, Karlocai, Kristof, Graham, Ian, Shelley, Emer, Behar, Shlomo, Maggioni, Aldo, Grabauskiene, Virginija, Deckers, Jaap, Asmussen, Inger, Stepinska, Janina, Gonçalves, Lino, Mareev, Vyacheslav, Riecansky, Igor, Kenda, Miran F., Alonso, Angeles, Lopez-Sendon, José Luis, Rosengren, Annika, Buser, Peter, Okay, Tugrul, Sychov, Oleg, Fox, Kevin, Wood, David, Boersma, Eric, Crijns, Harry, Fox, Kim, McGregor, Keith, Mulder, Barbara, Priori, Sylvia, Rydén, Lars, Tavazzi, Luigi, Vahanian, Alec, Vardas, Panos, Wijns, William, Sarkisyan, Karine, Glogar, H. D., Derntl, Michael, Frick, Matthias, Pachinger, O., Zwick, Ralf, Vrints, Christiaan, Van Hertbruggen, Els, Vercammen, Marc, Sysmans, Tineke, Schroeder, E., Domange, Juliette, De Pril, Hilde, De Vriese, Johan, Van Hecke, Tonny, Legrand, V., Gillon, Marie-France, Richardy, Michel, Doneux, P., Petrov, Ivo, Jorgova, J., Starcevic, Boris, Eeckhout, Eric, Berger, Alexandre, Prudent, Veronique, Camenzind, E., Masson, Nicolas, Zambartas, Costas, Kleanthous, Helen, Widimsky, Petr, Stellova, Blanka, Aschermann, Michael, Simek, Stanislav, Kautzner, J., Karmazin, Vladimir, Svab, P., Indrak, Jan, Branny, M., Hladilova, Kveta, Kala, P., Thayssen, P., Cappelen, Helle, Jensen, Lisette Okkels, Gitt, A., Gehrke, Konstanze, Erbel, R., Gutersohn, Achim, Eggebrecht, Holger, Al Khani, Murad, Sechtem, Udo, Rosenberger, Antje, Vogelsberg, Holger, Klepzig, H., Schmidt, Arnold, Silber, Sigmund, Mau, Birgit, Leuner, Christian, Czyborra, Karen, Reuschling, Christina, Muno, Eva, Kleber, F., Rux, Sascha, Zeymer, U., Saad, Aly, Ibrahim, B. S. S., Elabady, Maged, Castro Beiras, A., Fernandez, Jorge Salgado, Navarro Del Arno, Felipe, Iniguez Romo, A., Cruz Fernandez, J. M., Mayoreal, Alejandro Recio, Rebanal, Franciso Javier Rivero, De La Borbolla, Mariano Garcia, Chaparro, Marinela, Brotons, C., Permanyer Miralda, C., Vilai Perez, Srta Irma, Moris, Cesar, Fernandez Aviles, F., De La Fuente Galan, Luis, Vinuela, Paula Tejedor, Malpartida De Torres, F., Mora, Javier, Rodriguez, Ignacio Santos, Bustamante, Itziar Piedra, Sanchez Fernandez, Pedro L., Diago Torrent, J. L., Diez Gil, Jose L., Perpinan, Javier, Palacios Motilla, V., Soledad Alcasena Juango, M., Berjon-Reyero, Jesus, Melgares Moreno, R., Guerrero, Juan Carlos Fernandez, Lehto, S., Savolainen, Kirsti, Nieminen, M. S., Syvanne, Mikko, Cohen-Solal, A., Oboa, Antoine-Sylvain, Bassand, J. P., Espinosa, Denis Pales, Jouet, Veronique, Montalescot, G., Gallois, Vanessa, Daubert, J. C., Clerc, Jean Michel, Machecourt, Jacques, Cottin, Y., Walker, D., Holland, Fhiona, Wood, D., Prosser, Jenni, Muir, Lis, Barber, Kate, Cleland, J. G. F., Cook, Jocelyn, Chapichadze, Zaza, Christos, Ioannis Skoularigisn Athanasiou, Tsiavou, Nastasia, Chrysohoou, Christina, Manginas, Athanassios, Terrovitis, John, Kanakakis, John, Vavuranakis, Manolis, Drakos, Stavros, Farmakis, Thomas, Samara, C., Papakosta, Christina, Bourantas, Christos, Michalis, L. K., Christos, Mpourantas, Foussas, Stefanos, Adamopoulou, Evdokia, Vardas, P. E., Marketou, Mary, Alotti, N., Basa, Anna Maria, Vigh, Andras, Preda, Istvan, Csoti, Eva, Keltai, M., Kerkovits, G., Hendler, Alberto, Blatt, Alex, Beyar, R., Shefer, Arie, Halon, David, Bentzvi, Margalait, Avramovitch, Naomi, Bakst, Avinoam, Cafri, Carlos, Grosbard, Aviva, Margolis, Bella, Suleiman, Khalid, Banai, Shmuel, Meerkin, David, Mosseri, Morris, Guita, Pnina, Jabara, Rifat, Jafari, Jamal, Ben Shitrit, Debi, Ghasan, null, Salameh, null, Brezins, Marc, Van Den Akker-Berman, Lily, Guetta, Victor, Rozenman, Yoseph, Biagini, A., Berti, Sergio, Ferrero, Massimo, Colombo, A., Roccaforte, R., Milici, Caterina, Scarpino, L., Salvi, A., Desideri, Alessandro, Sabbadin, Daniela, Galassi, Alfredo, Giuffrida, Giuseppe, Rognoni, Andrea, Vassanelli, Corrado, Paffoni, Paola, Cioppa, Angelo, Rubino, Paolo, De Carlo, Marco, Petronio, Anna Sonia, Naccarella, F., Saia, Francesco, Marzocchi, Antonio, Maranga, Stefano Sdringola, Presbitero, P., Valsecchi, Fazya, Piscione, Federico, Esposito, Giovanni, Santini, Napoli M., Tubaro, Marco, Erglis, A., Narbute, Inga, Kavoliuniene, Ausra, Zaliunas, R., Navickas, Ramunas, Grabauskiene, V., Luckute, Davia, Subkovas, Eduardas, Wagner, Daniel, Vermeer, F., Lousberg, Aimee, Fransen, Heidi, Breeman, Arno, Tebbe, Henriette, De Boer, M. J., Van Der Wal, Metske, Deckers, J., Vos, Jeroen, Leenders, C. M., Veerhoek, M. J., Jansen, Chris, Bijl, M., Koppelaar, Colinda, Van Den Linden, null, Brons, R., Widdershofen, J. W. M. G., Broers, Herman, Kontny, F., Jonzon, Marianne, Wodniecki, Jan, Tomasik, Andrzej, Trusz-Gluza, M., Nowak, Seweryn, Ruzyllo, Witold, Deptuch, Tomasz, Marques, Jorge, Matias, F., Madeira, H., Oliveira, Joaquim, Sargento, Luis, Ionac, Adina, Dragulescu, Iosif Stefan, Mut-Vitcu, Bogdan, Maximov, Daniela, Dorobantu, M., Apetrei, E., Niculescu, Rodica, Petrescu, Virgil, Bucsa, Adrian, Deleanu, Dan, Benedek, I. S., Hintea, Theodora, Aronov, D., Tikhomirova, Elena, Kranjec, I., Prokselj, Katja, Kanic, Vojko, Sepetoglu, Ahmet, Aytekin, S., Aytekin, V., Catakoglu, Alp Burak, Parlar, Hayri, Tufekcioglu, Suavi, Ozyedek, Zeki, Baltali, Mehmet, Kiziltan, null, Vukovic, Milan, Neskovic, A. N., Lenzen, M. J, Boersma, E, Bertrand, Me, Maier, W, Moris, C, Esposito, Giovanni, Piscione, Federico, Sechtem, U, Stahle, E, Widimsky, P, de Jaegere, P, Scholte op Reimer, W. J. M, Mercado, N, Wijns, W., University of Zurich, Wijns, W, Lenzen, M. J., Boersma, E., Bertrand, M. E., Maier, W., Moris, C., Piscione, F., Sechtem, U., Stahle, E., Widimsky, P., De Jaegere, P., Scholte Op Reimer, W. J. M., Mercado, N., Meier, B., Sergeant, P., Vos, J., Unger, F., Manini, Malika, Bramley, Claire, Laforest, Valérie, Taylor, Charle, Del Gaiso, Susan, Huber, Kurt, De Backer, Guy, Sirakova, Vera, Cerbak, Roman, Thayssen, Per, Lehto, Seppo, Blanc, Jean-Jacque, Delahaye, Françoi, Kobulia, Bondo, Zeymer, Uwe, Cokkinos, Denni, Karlocai, Kristof, Graham, Ian, Shelley, Emer, Behar, Shlomo, Maggioni, Aldo, Grabauskiene, Virginija, Deckers, Jaap, Asmussen, Inger, Stepinska, Janina, Gonçalves, Lino, Mareev, Vyacheslav, Riecansky, Igor, Kenda, Miran F., Alonso, Angele, Lopez-Sendon, José Lui, Rosengren, Annika, Buser, Peter, Okay, Tugrul, Sychov, Oleg, Fox, Kevin, Wood, David, Boersma, Eric, Crijns, Harry, Fox, Kim, Mcgregor, Keith, Mulder, Barbara, Priori, Sylvia, Rydén, Lar, Tavazzi, Luigi, Vahanian, Alec, Vardas, Pano, Wijns, William, Sarkisyan, Karine, Glogar, H. D., Derntl, Michael, Frick, Matthia, Pachinger, O., Zwick, Ralf, Vrints, Christiaan, Van Hertbruggen, El, Vercammen, Marc, Sysmans, Tineke, Schroeder, E., Domange, Juliette, De Pril, Hilde, De Vriese, Johan, Van Hecke, Tonny, Legrand, V., Gillon, Marie-France, Richardy, Michel, Doneux, P., Petrov, Ivo, Jorgova, J., Starcevic, Bori, Eeckhout, Eric, Berger, Alexandre, Prudent, Veronique, Camenzind, E., Masson, Nicola, Zambartas, Costa, Kleanthous, Helen, Widimsky, Petr, Stellova, Blanka, Aschermann, Michael, Simek, Stanislav, Kautzner, J., Karmazin, Vladimir, Svab, P., Indrak, Jan, Branny, M., Hladilova, Kveta, Kala, P., Thayssen, P., Cappelen, Helle, Jensen, Lisette Okkel, Gitt, A., Gehrke, Konstanze, Erbel, R., Gutersohn, Achim, Eggebrecht, Holger, Al Khani, Murad, Sechtem, Udo, Rosenberger, Antje, Vogelsberg, Holger, Klepzig, H., Schmidt, Arnold, Silber, Sigmund, Mau, Birgit, Leuner, Christian, Czyborra, Karen, Reuschling, Christina, Muno, Eva, Kleber, F., Rux, Sascha, Zeymer, U., Saad, Aly, Ibrahim, B. S. S., Elabady, Maged, Castro Beiras, A., Fernandez, Jorge Salgado, Navarro Del Arno, Felipe, Iniguez Romo, A., Cruz Fernandez, J. M., Mayoreal, Alejandro Recio, Rebanal, Franciso Javier Rivero, De La Borbolla, Mariano Garcia, Chaparro, Marinela, Brotons, C., Permanyer Miralda, C., Vilai Perez, Srta Irma, Moris, Cesar, Fernandez Aviles, F., De La Fuente Galan, Lui, Vinuela, Paula Tejedor, Malpartida De Torres, F., Mora, Javier, Rodriguez, Ignacio Santo, Bustamante, Itziar Piedra, Sanchez Fernandez, Pedro L., Diago Torrent, J. L., Diez Gil, Jose L., Perpinan, Javier, Palacios Motilla, V., Soledad Alcasena Juango, M., Berjon-Reyero, Jesu, Melgares Moreno, R., Guerrero, Juan Carlos Fernandez, Lehto, S., Savolainen, Kirsti, Nieminen, M. S., Syvanne, Mikko, Cohen-Solal, A., Oboa, Antoine-Sylvain, Bassand, J. P., Espinosa, Denis Pale, Jouet, Veronique, Montalescot, G., Gallois, Vanessa, Daubert, J. C., Clerc, Jean Michel, Machecourt, Jacque, Cottin, Y., Walker, D., Holland, Fhiona, Wood, D., Prosser, Jenni, Muir, Li, Barber, Kate, Cleland, J. G. F., Cook, Jocelyn, Chapichadze, Zaza, Christos, Ioannis Skoularigisn Athanasiou, Tsiavou, Nastasia, Chrysohoou, Christina, Manginas, Athanassio, Terrovitis, John, Kanakakis, John, Vavuranakis, Manoli, Drakos, Stavro, Farmakis, Thoma, Samara, C., Papakosta, Christina, Bourantas, Christo, Michalis, L. K., Christos, Mpouranta, Foussas, Stefano, Adamopoulou, Evdokia, Vardas, P. E., Marketou, Mary, Alotti, N., Basa, Anna Maria, Vigh, Andra, Preda, Istvan, Csoti, Eva, Keltai, M., Kerkovits, G., Hendler, Alberto, Blatt, Alex, Beyar, R., Shefer, Arie, Halon, David, Bentzvi, Margalait, Avramovitch, Naomi, Bakst, Avinoam, Cafri, Carlo, Grosbard, Aviva, Margolis, Bella, Suleiman, Khalid, Banai, Shmuel, Meerkin, David, Mosseri, Morri, Guita, Pnina, Jabara, Rifat, Jafari, Jamal, Ben Shitrit, Debi, Ghasan, Null, Salameh, Null, Brezins, Marc, Van Den Akker-Berman, Lily, Guetta, Victor, Rozenman, Yoseph, Biagini, A., Berti, Sergio, Ferrero, Massimo, Colombo, A., Roccaforte, R., Milici, Caterina, Scarpino, L., Salvi, A., Desideri, Alessandro, Sabbadin, Daniela, Galassi, Alfredo, Giuffrida, Giuseppe, Rognoni, Andrea, Vassanelli, Corrado, Paffoni, Paola, Cioppa, Angelo, Rubino, Paolo, De Carlo, Marco, Petronio, Anna Sonia, Naccarella, F., Saia, Francesco, Marzocchi, Antonio, Maranga, Stefano Sdringola, Presbitero, P., Valsecchi, Fazya, Santini, Napoli M., Tubaro, Marco, Erglis, A., Narbute, Inga, Kavoliuniene, Ausra, Zaliunas, R., Navickas, Ramuna, Grabauskiene, V., Luckute, Davia, Subkovas, Eduarda, Wagner, Daniel, Vermeer, F., Lousberg, Aimee, Fransen, Heidi, Breeman, Arno, Tebbe, Henriette, De Boer, M. J., Van Der Wal, Metske, Deckers, J., Vos, Jeroen, Leenders, C. M., Veerhoek, M. J., Jansen, Chri, Bijl, M., Koppelaar, Colinda, Van Den Linden, Null, Brons, R., Widdershofen, J. W. M. G., Broers, Herman, Kontny, F., Jonzon, Marianne, Wodniecki, Jan, Tomasik, Andrzej, Trusz-Gluza, M., Nowak, Seweryn, Ruzyllo, Witold, Deptuch, Tomasz, Marques, Jorge, Matias, F., Madeira, H., Oliveira, Joaquim, Sargento, Lui, Ionac, Adina, Dragulescu, Iosif Stefan, Mut-Vitcu, Bogdan, Maximov, Daniela, Dorobantu, M., Apetrei, E., Niculescu, Rodica, Petrescu, Virgil, Bucsa, Adrian, Deleanu, Dan, Benedek, I. S., Hintea, Theodora, Aronov, D., Tikhomirova, Elena, Kranjec, I., Prokselj, Katja, Kanic, Vojko, Sepetoglu, Ahmet, Aytekin, S., Aytekin, V., Catakoglu, Alp Burak, Parlar, Hayri, Tufekcioglu, Suavi, Ozyedek, Zeki, Baltali, Mehmet, Kiziltan, Null, Vukovic, Milan, Neskovic, A. N., Cardiology, Lenzen, Mj, and Scholte op Reimer, Wj

Subjects
Practice survey, Male, Coronary Stenosi, Coronary angiography, medicine.medical_treatment, Myocardial Infarction, Coronary Artery Disease, Angina, Coronary artery disease, Myocardial Revascularization, Stent, Myocardial infarction, Coronary Artery Bypass, Angioplasty, Balloon, Coronary, CABG, PCI, Professional Practice, Health Survey, Middle Aged, Europe, Treatment Outcome, Epidemiologic Method, Practice Guidelines as Topic, Cardiology, Stents, Female, Guideline Adherence, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, outcome, Euro Heart Survey, 610 Medicine & health, Platelet Glycoprotein GPIIb-IIIa Complex, 142-005 142-005, 2705 Cardiology and Cardiovascular Medicine, Angioplasty, Internal medicine, medicine, Humans, Angina, Unstable, cardiovascular diseases, Interventional cardiology, Unstable angina, business.industry, Coronary Artery Bypa, Coronary Stenosis, Percutaneous coronary intervention, Length of Stay, medicine.disease, Health Surveys, Conventional PCI, 570 Life sciences, biology, Epidemiologic Methods, business
Abstract

AIMS: The purpose of the Euro Heart Survey Programme of the European Society of Cardiology is to evaluate to which extent clinical practice endorses existing guidelines as well as to identify differences in population profiles, patient management, and outcome across Europe. The current survey focuses on the invasive diagnosis and treatment of patients with established coronary artery disease (CAD). METHODS AND RESULTS: Between November 2001 and March 2002, 7769 consecutive patients undergoing invasive evaluation at 130 hospitals (31 countries) were screened for the presence of one or more coronary stenosis >50% in diameter. Patient demographics and comorbidity, clinical presentation, invasive parameters, treatment options, and procedural techniques were prospectively entered in an electronic database (550 variables+29 per diseased coronary segment). Major adverse cardiac events (MACE) were evaluated at 30 days and 1 year. Out of 5619 patients with angiographically proven coronary stenosis (72% of screened population), 53% presented with stable angina while ST elevation myocardial infarction (STEMI) was the indication for coronary angiography in 16% and non-ST segment elevation myocardial infarction or unstable angina in 30%. Only medical therapy was continued in 21%, whereas mechanical revascularization was performed in the remainder [percutaneous coronary intervention (PCI) in 58% and coronary artery bypass grafting (CABG) in 21%]. Patients referred for PCI were younger, were more active, had a lower risk profile, and had less comorbid conditions. CABG was performed mostly in patients with left main lesions (21%), two- (25%), or three-vessel disease (67%) with 4.1 diseased segments, on average. Single-vessel PCI was performed in 82% of patients with either single- (45%), two- (33%), or three-vessel disease (21%). Stents were used in 75% of attempted lesions, with a large variation between sites. Direct PCI for STEMI was performed in 410 cases, representing 7% of the entire workload in the participating catheterization laboratories. Time delay was within 90 min in 76% of direct PCI cases. In keeping with the recommendations of practice guidelines, the survey identified under-use of adjunctive medication (GP IIb/IIIa receptor blockers, statins, and angiotensin-converting enzyme-inhibitors). Mortality rates at 30 days and 1 year were low in all subgroups. MACE primarily consisted of repeat PCI (12%). CONCLUSION: The current Euro Heart Survey on coronary revascularization was performed in the era of bare metal stenting and provides a global European picture of the invasive approach to patients with CAD. These data will serve as a benchmark for the future evaluation of the impact of drug-eluting stents on the practice of interventional cardiology and bypass surgery.

Published
2005

22. Depression influences the quality of diabetes-related self-management activities in elderly patients with type 2 diabetes: a cross-sectional study

Author

Cristian Oancea, Bogdan Timar, Gabriela Mut-Vitcu, Ioan Cosmin Citu, and Romulus Timar

Subjects
Male, medicine.medical_specialty, Cross-sectional study, media_common.quotation_subject, 030209 endocrinology & metabolism, Type 2 diabetes, Severity of Illness Index, Diabetes Complications, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Diabetes mellitus, Surveys and Questionnaires, self-care, Medicine, Humans, Quality (business), 030212 general & internal medicine, Exercise, Depression (differential diagnoses), media_common, Aged, Original Research, Aged, 80 and over, Psychiatric Status Rating Scales, Self-management, diabetes, business.industry, Depression, Romania, General Medicine, Middle Aged, medicine.disease, Self Care, Cross-Sectional Studies, Logistic Models, Diabetes Mellitus, Type 2, quality of life, Clinical Interventions in Aging, Multivariate Analysis, Self care, Physical therapy, Female, Geriatrics and Gerontology, business
Abstract

Gabriela Mut-Vitcu,1 Bogdan Timar,2 Romulus Timar,1 Cristian Oancea,3 Ioan Cosmin Citu4 1Second Department of Internal Medicine, 2Department of Functional Sciences, 3Department of Infectious Diseases, 4Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania Purpose: To evaluate the prevalence of depression and its impact on the quality of diabetes-related self-care activities in elderly patients with type 2 diabetes. Patients and methods: In this cross-sectional study, 184 patients with type 2 diabetes were enrolled. Depression was evaluated using Patient Health Questionnaire-9 while the quality of diabetes-related self-care activities was assessed using the Summary of Diabetes-Related Self Care Activities Questionnaire. Results: In our study group, 53.3% of the patients had moderate depression, 17.9% had severe depression, and 28.8% had no depression symptoms. Patient’s age (P=0.024), presence of diabetic neuropathy (P

Published
2016

23. Whole-Body Distribution and Radiation Dosimetry of 11C-(+)-PHNO, a D2/3 Agonist Ligand

Author

Alvina Ng, Alan A. Wilson, Peter M. Bloomfield, Pablo Rusjan, Romina Mizrahi, Irina Vitcu, and Sylvain Houle

Subjects
Adult, Male, Agonist, Adult male, medicine.drug_class, Radiation, Ligands, Effective dose (radiation), Oxazines, medicine, Humans, Dosimetry, Tissue Distribution, Radiology, Nuclear Medicine and imaging, Radiometry, Receptors, Dopamine D2, business.industry, Receptors, Dopamine D3, Healthy subjects, Internal radiation, Organ Size, Positron-Emission Tomography, Dopamine Agonists, Female, Whole body, Nuclear medicine, business
Abstract

Using PET, we measured the whole-body distribution of 11C-(+)-PHNO (11C-(+)-4-propyl-9-hydroxynaphthoxazine), a D2/3 agonist, as a function of time in adult subjects in order to determine the internal radiation dose. Methods: PET whole-body data were acquired after the injection of 11C-(+)-PHNO (∼360 MBq) in 6 healthy subjects (3 male and 3 female). The PET acquisition duration was a maximum of 112.5 min, and 9 discrete time frames were obtained. After reconstruction of the emission data, 6 organs were identified in the images as exhibiting uptake above background levels. Regions of interest were delineated on these organs, and time–activity curves were generated. The time–activity curve data were corrected for the injected activity, specific organ density, and volume, from which normalized accumulated activities (previously known as residence times) were calculated. The normalized accumulated activities were then used with the software code OLINDA/EXM 1.1 to calculate the internal doses for the standard adult male and female models. Results: The mean effective dose was estimated to be 4.5 ± 0.3 μSv/MBq when all subjects were included and the male model was applied for the dosimetry calculation, and the mean effective dose was estimated to be 5.2 ± 0.2 μSv/MBq when the females were considered separately and the female model was applied for the calculation. The organ receiving the highest dose was the liver (17.9 ± 3.9 μSv/MBq), followed by the kidneys (14.3 ± 3.6 μSv/MBq) and the urinary bladder wall (13.5 ± 3.7 μSv/MBq). Conclusion: The estimated radiation doses for 11C-(+)-PHNO are similar to those reported for other radiotracers labeled with 11C. 11C-(+)-PHNO may be used for multiple PET scans in the same subject and remain within regulatory guidelines.

Published
2012

24. Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [18F]-FEPPA and Positron Emission Tomography

Author

Peter M. Bloomfield, Pablo Rusjan, Irina Vitcu, Romina Mizrahi, Jeffrey H. Meyer, Sylvain Houle, and Alan A. Wilson

Subjects
Adult, Male, Fluorine Radioisotopes, Pyridines, Coefficient of variation, Young Adult, Translocator protein, medicine, Radioligand, Humans, Anilides, Aged, biology, medicine.diagnostic_test, business.industry, Chemistry, Outcome measures, Brain, Binding potential, Human brain, Middle Aged, medicine.anatomical_structure, Neurology, Positron emission tomography, Positron-Emission Tomography, biology.protein, Original Article, Female, Neurology (clinical), Tomography, Radiopharmaceuticals, Cardiology and Cardiovascular Medicine, Nuclear medicine, business, Protein Binding
Abstract

This article describes the kinetic modeling of [18F]-FEPPA binding to translocator protein 18 kDa in the human brain using high-resolution research tomograph (HRRT) positron emission tomography. Positron emission tomography scans were performed in 12 healthy volunteers for 180 minutes. A two-tissue compartment model (2-CM) provided, with no exception, better fits to the data than a one-tissue model. Estimates of total distribution volume ( VT), specific distribution volume ( VS), and binding potential ( BPND) demonstrated very good identifiability (based on coefficient of variation ( COV)) for all the regions of interest (ROIs) in the gray matter ( COV VT < 7%, COV VS < 8%, COV BPND < 11%). Reduction of the length of the scan to 2 hours is feasible as VS and VT showed only a small bias (6% and 7.5%, respectively). Monte Carlo simulations showed that, even under conditions of a 500% increase in specific binding, the identifiability of VT and VS was still very good with COVT values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of VT as an appropriate and feasible outcome measure for [18F]-FEPPA.

Published
2011

25. Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans

Author

Philip Seeman, Irina Vitcu, Pablo Rusjan, Romina Mizrahi, David C. Mamo, Shitij Kapur, Ariel Graff-Guerrero, Nathalie Ginovart, Alan A. Wilson, and Matthaeus Willeit

Subjects
Male, Time Factors, Dopamine, Striatum, ddc:616.89, Substantia Nigra/diagnostic imaging/metabolism, Basal ganglia, Radioligand, Tissue Distribution, Carbon Radioisotopes, Receptors, Dopamine D2/agonists/metabolism, Research Articles, Raclopride, Brain Mapping, Dopamine Agonists/metabolism/pharmacokinetics, Radiological and Ultrasound Technology, Chemistry, Putamen, Substantia Nigra, Dopamine D2 Receptor Antagonists, Globus pallidus, Neurology, Dopamine Agonists, Female, Anatomy, medicine.drug, Adult, Agonist, medicine.medical_specialty, Raclopride/metabolism/pharmacokinetics, medicine.drug_class, Globus Pallidus, Binding, Competitive, Binding, Competitive/drug effects/physiology, Internal medicine, Brain Mapping/methods, Oxazines, medicine, Humans, Radiology, Nuclear Medicine and imaging, Corpus Striatum/diagnostic imaging/metabolism, Globus Pallidus/diagnostic imaging/metabolism, Neostriatum/diagnostic imaging/metabolism, Receptors, Dopamine D2, Antagonist, Positron-Emission Tomography/methods, Dopamine Antagonists/metabolism/pharmacokinetics, Corpus Striatum, Dopamine/metabolism, Neostriatum, Endocrinology, nervous system, Positron-Emission Tomography, Dopamine Antagonists, Oxazines/metabolism/pharmacokinetics, Neurology (clinical), Neuroscience
Abstract

The D(2) receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [(11)C]‐(+)‐PHNO is a PET D(2) agonist radioligand and therefore provides a preferential measure of the D(2) (high) receptors. In contrast, [(11)C]raclopride is an antagonist radioligand and thus binds with equal affinity to the D(2) high‐ and low‐affinity states. The aim was to compare the brain uptake, distribution and binding characteristics between [(11)C]‐(+)‐PHNO and [(11)C]raclopride in volunteers using a within‐subject design. Both radioligands accumulated in brain areas rich in D(2)/D(3)‐receptors. However, [(11)C]‐(+)‐PHNO showed preferential uptake in the ventral striatum and globus pallidus, while [(11)C]raclopride showed preferential uptake in the dorsal striatum. Mean binding potentials were higher in the putamen (4.3 vs. 2.8) and caudate (3.4 vs 2.1) for [(11)C]raclopride, equal in the ventral‐striatum (3.4 vs. 3.3), and higher in the globus pallidus for [(11)C]‐(+)‐PHNO (1.8 vs. 3.3). Moreover [(11)C]‐(+)‐PHNO kinetics in the globus pallidus showed a slower washout than other regions. One explanation for the preferential binding of [(11)C]‐(+)‐PHNO in the globus pallidus and ventral‐striatum could be the presence of a greater proportion of high‐ vs. low‐affinity receptors in these areas. Alternatively, the observed distribution could also be explained by a preferential binding of D(3)‐over‐D(2) with [(11)C]‐(+)‐PHNO. This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease. Hum Brain Mapp 2008. © 2007 Wiley‐Liss, Inc.

Published
2008

26. Clinical improvement after treatment with VEGF165 in patients with severe chronic lower limb ischaemia

Author

Raluca Iman, Catalin Marian, Adriana-Maria Neghina, Edward Seclaman, Bogdan Mut-Vitcu, Æ Stefan I. Dragulescu, Andrei Anghel, and Lorand Savu

Subjects
medicine.medical_specialty, medicine.medical_treatment, Genetic enhancement, chemistry.chemical_compound, Gene therapy, Text mining, Internal medicine, Genetics, medicine, Genetics(clinical), Adverse effect, Saline, Genetics (clinical), medicine.diagnostic_test, business.industry, Lower limb ischaemia, Molecular medicine, Surgery, Vascular endothelial growth factor, medicine.anatomical_structure, chemistry, Angiography, Cardiology, business, Neo-vascularization, Research Article, Blood vessel
Abstract

The present study focuses on the application of a therapeutic strategy in patients with chronic severe lower limb ischaemia using a plasmid vector encoding the vascular endothelial growth factor (phVEGF165). It has been shown that VEGF promotes neo-vascularization and blood vessel network formation and thus might have the ability to improve blood-flow at the level of the affected limbs. However, little information is available regarding the necessary level of expression of VEGF and its possible related adverse effects. We have subcloned VEGF 165 isoform into pCMV-Script expression vector (Stratagene) under the control of the CMV promoter. Three patients with chronic ischaemia of the lower limb, considered as not suitable for surgical re-vascularization, received intramuscular injection with 0.5 ml saline solution containing 1011 copies of VEGF 165 plasmid. The clinical evolution has been monitored by angiography and estimated by walking time on the rolling carpet (Gardner protocol). Two months after therapy, all three patients showed complete relief of rest pain, improvement of ischaemic ulcer lesions and increased walking distance on the rolling carpet most probably due to appearance of newly formed collateral vessels.

Published
2007

27. Separate brain regions code for salience vs. valence during reward prediction in humans

Author

Irina Vitcu, Shitij Kapur, Jimmy Jensen, Adrian P. Crawley, Matthäus Willeit, David J. Mikulis, and Andrew J. A. Smith

Subjects
Adult, Male, Conditioning, Classical, Models, Neurological, Choice Behavior, Brain mapping, Basal Ganglia, Reward, Salience (neuroscience), Basal ganglia, Avoidance Learning, medicine, Humans, Radiology, Nuclear Medicine and imaging, Valence (psychology), Research Articles, Brain Mapping, Radiological and Ultrasound Technology, Ventral striatum, Magnetic Resonance Imaging, medicine.anatomical_structure, nervous system, Neurology, Incentive salience, Female, Orbitofrontal cortex, Neurology (clinical), Anatomy, Aversive Stimulus, Psychology, Neuroscience
Abstract

Predicting rewards and avoiding aversive conditions is essential for survival. Recent studies using computational models of reward prediction implicate the ventral striatum in appetitive rewards. Whether the same system mediates an organism's response to aversive conditions is unclear. We examined the question using fMRI blood oxygen level‐dependent measurements while healthy volunteers were conditioned using appetitive and aversive stimuli. The temporal difference learning algorithm was used to estimate reward prediction error. Activations in the ventral striatum were robustly correlated with prediction error, regardless of the valence of the stimuli, suggesting that the ventral striatum processes salience prediction error. In contrast, the orbitofrontal cortex and anterior insula coded for the differential valence of appetitive/aversive stimuli. Given its location at the interface of limbic and motor regions, the ventral striatum may be critical in learning about motivationally salient stimuli, regardless of valence, and using that information to bias selection of actions. Inc. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc.

Published
2007

28. Dicke-narrowed spectral line shapes of CO in Ar: Experimental results and a revised interpretation

Author

A. D. May, Franck Thibault, James R. Drummond, Roman Ciuryło, Richard Wehr, and A. Vitcu

Subjects
Physics, Density matrix, business.industry, Inelastic collision, Magnitude (mathematics), Noise (electronics), Atomic and Molecular Physics, and Optics, Spectral line, Spectral line shape, Computational physics, Optics, Physical and Theoretical Chemistry, business, Constant (mathematics), Spectroscopy, Line (formation)
Abstract

The shapes of Dicke-narrowed spectral lines in the fundamental P -branch of CO in Ar are studied by comparing high-resolution measurements and theoretical calculations. The measured spectra were recorded at temperatures between 214 and 324 K, and at pressures between 0.025 and 1 atm. The calculations are based on solving a transport/relaxation equation for the appropriate off-diagonal element of the density matrix; they use a realistic intermolecular potential to determine the speed-dependent collisional broadening, and a rigid sphere potential to determine the Dicke narrowing. It is found that the calculations can reproduce the measured spectra within the experimental noise under all conditions, but that the magnitude of the Dicke narrowing in the measured spectra is 70–90% less than predicted from the mass diffusion constant. A revised view of the collision operator resolves the discrepancy in principle, and leads to a better understanding of the line shape problem in general.

Published
2006

29. Collisional line shifting and broadening in the fundamental P-branch of CO in Ar between 214 and 324K

Author

Richard Wehr, Franck Thibault, James R. Drummond, A. Vitcu, and A. D. May

Subjects
Physics, Density matrix, business.industry, Power law, Noise (electronics), Atomic and Molecular Physics, and Optics, Spectral line, Spectral line shape, Optics, Potential energy surface, Rigid sphere, Physical and Theoretical Chemistry, Atomic physics, business, Spectroscopy, Line (formation)
Abstract

The collisional shifts and widths of several P -branch spectral lines in the fundamental band of CO–Ar have been measured at temperatures between 214 and 324 K and pressures between 0.025 and 1 atm. The widths have been determined using a line shape model based on the solution of the transport/relaxation equation for the appropriate off-diagonal element of the density matrix. The model uses a realistic molecular potential energy surface to calculate the speed dependence of the collisional broadening, and a rigid sphere potential to calculate the translational motion. It is found that both the shifting and broadening coefficients follow a power law dependence on the temperature. Additionally, it is demonstrated that studies have tended to overestimate the accuracy of collisional widths when the line shape model used to obtain the widths involves multiple fitted line shape parameters or fails to fit the measured spectra within the experimental noise.

Published
2006

30. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase

Author

Junchao Tong, Irina Vitcu, Pablo Rusjan, Romina Mizrahi, Isabelle Boileau, Alan A. Wilson, Asfandyar Mufti, Stephen J. Kish, Sylvain Houle, and Peter M. Bloomfield

Subjects
Adult, Male, Amidohydrolases, Image Processing, Computer-Assisted, Medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Tissue Distribution, Whole Body Imaging, Prospective Studies, Pet tracer, Radiometry, Public Facility, Border crossing, business.industry, Biphenyl Compounds, Middle Aged, medicine.disease, Positron-Emission Tomography, Female, Medical emergency, Carbamates, Radiopharmaceuticals, Nuclear medicine, business, Whole body, Whole-Body Irradiation
Abstract

1993 Objectives To determine by a national survey: 1) the frequency of detection by public screening facilities of radioactivity in patients (pts) who had been treated with 131I for differentiated thyroid cancer (DTC), 2) the types and frequency of the various public facilities where pts were detected, and 3) the management of these pts by the security personnel. Methods Data were tabulated from a Thyroid Cancer Survivors Association, Inc. (ThyCa) website survey from November 2013 to December 2013 and was emailed to ~30,000 associates of ThyCa. Answers were tabulated of respondents (rpds) who reported that s/he 1) was >18 yo, 2) had at least one tx of 131I, and 3) was responding for his/her last 131I tx. The study was approved by the IRB. Results Of 334 rpds, 6.9% (23) attempted to pass through a public facility security checkpoint. Of these 23 pts all were detected and the detections occurred in an airport (7), border crossing (7), government building (3), shopping mall (3), train station (2), and steel recycling plant (1). The security personnel questioned 19 rpds, released 14 rpds without change in travel plans, rescanned 9 rpds, released 1 rpd with change in travel plans, and denied passage in 1 rpd. Security personnel verified the rpd’s 131I tx by examining an official document from the treating physician that was provided by 14 rpds, calling the treating facility regarding 3 rspds, and operating radiation detectors to identify the type and source of radiation in 2 rspds. Security personnel did not verify 131I tx in 4 rspds. Conclusions Public detection of radioactivity after 131I tx is infrequent, occurring in only 6.9% of respondents. Although airports and border crossings accounted for 61% of the sites of detection, the number of detected respondents was very low, and further respondents of the survey continue to be collected.

Published
2014

31. Broadening, shifting, and line mixing in the 0310←0110 parallel Q branch of N2O

Author

James R. Drummond, A. D. May, Richard Wehr, Roman Ciuryło, and A. Vitcu

Subjects
Physics, Absorption spectroscopy, Spectrometer, Infrared, Band gap, business.industry, Inelastic collision, Atomic and Molecular Physics, and Optics, Pressure range, Optics, Medium pressure, Relaxation matrix, Physical and Theoretical Chemistry, Atomic physics, business, Spectroscopy
Abstract

The 03 1 0 ← 01 1 0 parallel Q branch of N 2 O has been studied at 297 K and over the pressure range 1–130 torr. Absorption spectra were recorded using a high resolution (1.5 MHz or 5 × 10 −5 cm −1 ) and high signal-to-noise (>3500:1) mid-infrared spectrometer based on difference-frequency infrared generation in AgGaS 2 . In the low-pressure range (1–11 torr) we obtained accurate values for the line strengths, the broadening coefficients, the weak mixing coefficients, and the overall shifting of the branch. The medium pressure results, ranging from 23 to 130 torr, were analyzed by treating the band as a whole, using a relaxation matrix formalism, based on an energy gap scaling law. We find, effectively, that only 36% of the rotationally inelastic collisions are associated with Q branch mixing, the rest presumably being associated with Q – P and Q – R mixing in the same vibrational band. The pressure shifting coefficient of the 03 1 0 ← 01 1 0 Q branch as a whole was also determined and found to be 5.8 × 10 −3 cm −1 /atm towards lower frequencies.

Published
2004

32. The additional value of patient-reported health status in predicting 1-year mortality after invasive coronary procedures: a report from the Euro Heart Survey on Coronary Revascularisation

Author

Lenzen M. J., Scholte Op Reimer W. J. M., Pedersen S. S., Boersma E., Maier W., Widimsky P., Simoons M. L., Mercado N. F., Wijns W., Bertrand M., Meier B., Sechtem U., Sergeant P., Stahle E., Unger F., Manini M., Bramley C., Laforest V., Taylor C., Del Gaiso S., Huber K., De Backer G., Sirakova V., Cerbak R., Thayssen P., Lehto S., Blanc J. -J., Delahaye F., Kobulia B., Zeymer U., Cokkinos D., Karlocai K., Graham I., Shelley E., Behar S., Maggioni A., Grabauskiene V., Deckers J., Asmussen I., Stepinska J., Goncalves L., Mareev V., Riecansky I., Kenda M. F., Alonso A., Lopez-Sendon J. L., Rosengren A., Buser P., Okay T., Sychov O., Fox K., Wood D., Crijns H., McGregor K., Mulder B., Priori S., Ryden L., Tavazzi L., Vahanian A., Vardas P., Sarkisyan K., Glogar H. D., Frick M., Pachinger O., Zwick R., Vrints C., Van Hertbruggen E., Vercammen M., Sysmans T., Schroeder E., Domange J., De Pril H., De Vriese J., Van Hecke T., Legrand V., Gillon M. -F., Richardy M., Doneux P., Petrov I., Jorgova J., Starcevic B., Eeckhout E., Berger A., Prudent V., Camenzind E., Masson N., Zambartas C., Kleanthous H., Stellova B., Aschermann M., Simek S., Kautzner J., Karmazin V., Svab P., Indrak J., Branny M., Hladilova K., Kala P., Cappelen H., Jensen L. O., Gitt A., Gehrke K., am Rhein L., Erbel R., Gutersohn A., Eggebrecht H., Al Khani M., Rosenberger A., Vogelsberg H., Klepzig H., Schmidt A., Silber S., Mau B., Leuner C., Czyborra K., Reuschling C., Muno E., Nauheim B., Kleber F., Rux S., Saad A., Elabady M., Beiras A. C., Fernandez J. S., del Arno F. N., Romo A. I., Fernandez J. M. C., Mayoreal A. R., Rebanal F. J. R., de la Borbolla M. G., Chaparro M., Brotons C., Miralda C. P., Vila i Perez S. I., Moris C., Aviles F. F., de la Fuente Galan L., Vinuela P. T., de Torres F. M., Mora J., Rodriguez I. S., Bustamante I. P., Fernandez P. L. S., Torrent J. L. D., Diez Gil J. L., Perpinan J., Motilla V. P., Juango M. S. A., Berjon-Reyero J., Moreno R. M., Guerrero J. C. F., Savolainen K., Syvanne M., Cohen-Solal A., Oboa A. -S., Bassand J. P., Espinosa D. P., Jouet V., Cedex B., Montalescot G., Gallois V., Daubert J. C., Clerc J. M., Machecourt J., Cottin Y., Walker D., Holland F., Prosser J., Muir L., Barber K., Cleland J. G. F., Cook J., Chapichadze Z., Christos I. S. A., Tsiavou N., Chrysohoou C., Manginas A., Terrovitis J., Kanakakis J., Vavuranakis M., Drakos S., Farmakis T., Samara C., Papakosta C., Bourantas C., Michalis L. K., Christos M., Foussas S., Adamopoulou E., Vardas P. E., Marketou M., Alotti N., Basa A. M., Vigh A., Preda I., Csoti E., Keltai M., Kerkovits G., Hendler A., Blatt A., Yakov B., Beyar R., Shefer A., Halon D., Bentzvi M., Avramovitch N., Bakst A., Saba K., Cafri C., Grosbard A., Sheva B., Margolis B., Suleiman K., Banai S., Meerkin D., Mosseri M., Guita P., Jabara R., Jafari J., Shitrit D. B., Ghasan Salameh, Brezins M., van den Akker-Berman L., Guetta V., Hashomer T., Rozenman Y., Biagini A., Berti S., Ferrero M., Colombo A., Roccaforte R., Milici C., Scarpino L., Salvi A., Desideri A., Sabbadin D., Veneto C., Galassi A., Giuffrida G., Rognoni A., Vassanelli C., Paffoni P., Cioppa A., Rubino P., de Carlo M., Petronio A. S., Naccarella F., Saia F., Marzocchi A., Maranga S. S., Presbitero P., Valsecchi F., Piscione F., Esposito G., Santini N. M., Tubaro M., Erglis A., Narbute I., Kavoliuniene A., Zaliunas R., Navickas R., Luckute D., Subkovas E., Wagner D., Vermeer F., Lousberg A., Fransen H., Breeman A., Tebbe H., De Boer M. J., van der Wal M., Vos J., Leenders C. M., Veerhoek M. J., Jansen C., Bijl M., Koppelaar C., den Linden V., Brons R., Widdershofen J. W. M. G., Broers H., Kontny F., Jonzon M., Wodniecki J., Tomasik A., Trusz-Gluza M., Nowak S., Ruzyllo W., Deptuch T., Marques J., Matias F., Madeira H., Oliveira J., Sargento L., Ionac A., Dragulescu I. S., Mut-Vitcu B., Maximov D., Dorobantu M., Apetrei E., Niculescu R., Petrescu V., Bucsa A., Deleanu D., Bucharest, Benedek I. S., Hintea T., Aronov D., Tikhomirova E., Kranjec I., Prokselj K., Kanic V., Sepetoglu A., Aytekin S., Aytekin V., Catakoglu A. B., Parlar H., Tufekcioglu S., Ozyedek Z., Baltali M., Kiziltan D., Vukovic M., Neskovic A. N., Cardiology, Lenzen, M. J., Scholte Op Reimer, W. J. M., Pedersen, S. S., Boersma, E., Maier, W., Widimsky, P., Simoons, M. L., Mercado, N. F., Wijns, W., Bertrand, M., Meier, B., Sechtem, U., Sergeant, P., Stahle, E., Unger, F., Manini, M., Bramley, C., Laforest, V., Taylor, C., Del Gaiso, S., Huber, K., De Backer, G., Sirakova, V., Cerbak, R., Thayssen, P., Lehto, S., Blanc, J. -J., Delahaye, F., Kobulia, B., Zeymer, U., Cokkinos, D., Karlocai, K., Graham, I., Shelley, E., Behar, S., Maggioni, A., Grabauskiene, V., Deckers, J., Asmussen, I., Stepinska, J., Goncalves, L., Mareev, V., Riecansky, I., Kenda, M. F., Alonso, A., Lopez-Sendon, J. L., Rosengren, A., Buser, P., Okay, T., Sychov, O., Fox, K., Wood, D., Crijns, H., Mcgregor, K., Mulder, B., Priori, S., Ryden, L., Tavazzi, L., Vahanian, A., Vardas, P., Sarkisyan, K., Glogar, H. D., Frick, M., Pachinger, O., Zwick, R., Vrints, C., Van Hertbruggen, E., Vercammen, M., Sysmans, T., Schroeder, E., Domange, J., De Pril, H., De Vriese, J., Van Hecke, T., Legrand, V., Gillon, M. -F., Richardy, M., Doneux, P., Petrov, I., Jorgova, J., Starcevic, B., Eeckhout, E., Berger, A., Prudent, V., Camenzind, E., Masson, N., Zambartas, C., Kleanthous, H., Stellova, B., Aschermann, M., Simek, S., Kautzner, J., Karmazin, V., Svab, P., Indrak, J., Branny, M., Hladilova, K., Kala, P., Cappelen, H., Jensen, L. O., Gitt, A., Gehrke, K., am Rhein, L., Erbel, R., Gutersohn, A., Eggebrecht, H., Al Khani, M., Rosenberger, A., Vogelsberg, H., Klepzig, H., Schmidt, A., Silber, S., Mau, B., Leuner, C., Czyborra, K., Reuschling, C., Muno, E., Nauheim, B., Kleber, F., Rux, S., Saad, A., Elabady, M., Beiras, A. C., Fernandez, J. S., del Arno, F. N., Romo, A. I., Fernandez, J. M. C., Mayoreal, A. R., Rebanal, F. J. R., de la Borbolla, M. G., Chaparro, M., Brotons, C., Miralda, C. P., Vila i Perez, S. I., Moris, C., Aviles, F. F., de la Fuente Galan, L., Vinuela, P. T., de Torres, F. M., Mora, J., Rodriguez, I. S., Bustamante, I. P., Fernandez, P. L. S., Torrent, J. L. D., Diez Gil, J. L., Perpinan, J., Motilla, V. P., Juango, M. S. A., Berjon-Reyero, J., Moreno, R. M., Guerrero, J. C. F., Savolainen, K., Syvanne, M., Cohen-Solal, A., Oboa, A. -S., Bassand, J. P., Espinosa, D. P., Jouet, V., Cedex, B., Montalescot, G., Gallois, V., Daubert, J. C., Clerc, J. M., Machecourt, J., Cottin, Y., Walker, D., Holland, F., Prosser, J., Muir, L., Barber, K., Cleland, J. G. F., Cook, J., Chapichadze, Z., Christos, I. S. A., Tsiavou, N., Chrysohoou, C., Manginas, A., Terrovitis, J., Kanakakis, J., Vavuranakis, M., Drakos, S., Farmakis, T., Samara, C., Papakosta, C., Bourantas, C., Michalis, L. K., Christos, M., Foussas, S., Adamopoulou, E., Vardas, P. E., Marketou, M., Alotti, N., Basa, A. M., Vigh, A., Preda, I., Csoti, E., Keltai, M., Kerkovits, G., Hendler, A., Blatt, A., Yakov, B., Beyar, R., Shefer, A., Halon, D., Bentzvi, M., Avramovitch, N., Bakst, A., Saba, K., Cafri, C., Grosbard, A., Sheva, B., Margolis, B., Suleiman, K., Banai, S., Meerkin, D., Mosseri, M., Guita, P., Jabara, R., Jafari, J., Shitrit, D. B., Ghasan, Salameh, Brezins, M., van den Akker-Berman, L., Guetta, V., Hashomer, T., Rozenman, Y., Biagini, A., Berti, S., Ferrero, M., Colombo, A., Roccaforte, R., Milici, C., Scarpino, L., Salvi, A., Desideri, A., Sabbadin, D., Veneto, C., Galassi, A., Giuffrida, G., Rognoni, A., Vassanelli, C., Paffoni, P., Cioppa, A., Rubino, P., de Carlo, M., Petronio, A. S., Naccarella, F., Saia, F., Marzocchi, A., Maranga, S. S., Presbitero, P., Valsecchi, F., Piscione, F., Esposito, G., Santini, N. M., Tubaro, M., Erglis, A., Narbute, I., Kavoliuniene, A., Zaliunas, R., Navickas, R., Luckute, D., Subkovas, E., Wagner, D., Vermeer, F., Lousberg, A., Fransen, H., Breeman, A., Tebbe, H., De Boer, M. J., van der Wal, M., Vos, J., Leenders, C. M., Veerhoek, M. J., Jansen, C., Bijl, M., Koppelaar, C., den Linden, V., Brons, R., Widdershofen, J. W. M. G., Broers, H., Kontny, F., Jonzon, M., Wodniecki, J., Tomasik, A., Trusz-Gluza, M., Nowak, S., Ruzyllo, W., Deptuch, T., Marques, J., Matias, F., Madeira, H., Oliveira, J., Sargento, L., Ionac, A., Dragulescu, I. S., Mut-Vitcu, B., Maximov, D., Dorobantu, M., Apetrei, E., Niculescu, R., Petrescu, V., Bucsa, A., Deleanu, D., Bucharest, Benedek, I. S., Hintea, T., Aronov, D., Tikhomirova, E., Kranjec, I., Prokselj, K., Kanic, V., Sepetoglu, A., Aytekin, S., Aytekin, V., Catakoglu, A. B., Parlar, H., Tufekcioglu, S., Ozyedek, Z., Baltali, M., Kiziltan, D., Vukovic, M., and Neskovic, A. N.

Subjects
Male, medicine.medical_specialty, Epidemiology, medicine.medical_treatment, Health Status, Coronary Artery Disease, Revascularization, Coronary artery disease, Cohort Studies, Risk Factors, Surveys and Questionnaires, medicine, Myocardial Revascularization, Surveys and Questionnaire, Humans, Prospective Studies, Prospective cohort study, Aged, business.industry, Risk Factor, Mortality rate, Confounding, Middle Aged, medicine.disease, Surgery, Europe, Prospective Studie, Treatment Outcome, Emergency medicine, Population study, Female, Cohort Studie, Cardiology and Cardiovascular Medicine, business, Human, Cohort study
Abstract

Objective: Self-perceived health status may be helpful in identifying patients at high risk for adverse outcomes. The Euro Heart Survey on Coronary Revascularization (EHS-CR) provided an opportunity to explore whether impaired health status was a predictor of 1-year mortality in patients with coronary artery disease (CAD) undergoing angiographic procedures. Methods: Data from the EHS-CR that included 5619 patients from 31 member countries of the European Society of Cardiology were used. Inclusion criteria for the current study were completion of a self-report measure of health status, the EuroQol Questionnaire (EQ-5D) at discharge and information on 1-year follow-up, resulting in a study population of 3786 patients. Results: The 1-year mortality was 3.2% (n = 120). Survivors reported fewer problems on the five dimensions of the EQ-5D as compared with non-survivors. A broad range of potential confounders were adjusted for, which reached a p

Published
2006

33. Patients enrolled in coronary intervention trials are not representative of patients in clinical practice: results from the Euro Heart Survey on Coronary Revascularization

Author

Hordijk-Trion M., Lenzen M., Wijns W., De Jaegere P., Simoons M. L., Scholte Op Reimer W. J. M., Bertrand M. E., Mercado N., Boersma E., Maier W., Meier B., Moris C., Piscione F., Sechtem U., Sergeant P., Stahle E., Vos J., Widimsky P., Unger F., Manini M., Bramley C., Laforest V., Taylor C., Del Gaiso S., Huber K., De Backer G., Sirakova V., Cerbak R., Thayssen P., Lehto S., Blanc J. -J., Delahaye F., Kobulia B., Zeymer U., Cokkinos D., Karlocai K., Graham I., Shelley E., Behar S., Maggioni A., Grabauskiene V., Deckers J., Asmussen I., Stepinska J., Goncalves L., Mareev V., Riecansky I., Kenda M. F., Alonso A., Lopez-Sendon J. L., Rosengren A., Buser P., Okay T., Sychov O., Fox K., Wood D., Crijns H., McGregor K., Mulder B., Priori S., Ryden L., Tavazzi L., Vahanian A., Vardas P., Sarkisyan K., Glogar H. D., Frick M., Pachinger O., Zwick R., Vrints C., Van Hertbruggen E., Vercammen M., Sysmans T., Schroeder E., Domange J., De Pril H., De Vriese J., Van Hecke T., Legrand V., Gillon M. -F., Richardy M., Doneux P., Petrov I., Jorgova J., Starcevic B., Eeckhout E., Berger A., Prudent V., Camenzind E., Masson N., Zambartas C., Kleanthous H., Stellova B., Aschermann M., Simek S., Kautzner J., Karmazin V., Svab P., Indrak J., Branny M., Hladilova K., Kala P., Cappelen H., Jensen L. O., Gitt A., Gehrke K., am Rhein L., Erbel R., Gutersohn A., Eggebrecht H., Al Khani M., Rosenberger A., Vogelsberg H., Klepzig H., Schmidt A., Silber S., Mau B., Leuner C., Czyborra K., Reuschling C., Muno E., Nauheim B., Kleber F., Rux S., Saad A., Elabady M., Beiras A. C., Fernandez J. S., del Arno F. N., Romo A. I., Fernandez J. M. C., Mayoreal A. R., Rebanal F. J. R., de la Borbolla M. G., Chaparro M., Brotons C., Miralda C. P., Vila i Perez S. I., Aviles F. F., de la Fuente Galan L., Vinuela P. T., de Torres F. M., Mora J., Rodriguez I. S., Bustamante I. P., Fernandez P. L. S., Torrent J. L. D., Gil J. L. D., Perpinan J., Motilla V. P., Juango M. S. A., Berjon-Reyero J., Moreno R. M., Guerrero J. C. F., Savolainen K., Syvanne M., Cohen-Solal A., Oboa A. -S., Bassand J. P., Espinosa D. P., Jouet V., Cedex B., Montalescot G., Gallois V., Daubert J. C., Clerc J. M., Machecourt J., Cottin Y., Walker D., Holland F., Prosser J., Muir L., Barber K., Cleland J. G. F., Cook J., Chapichadze Z., Christos I. S. A., Tsiavou N., Chrysohoou C., Manginas A., Terrovitis J., Kanakakis J., Vavuranakis M., Drakos S., Farmakis T., Samara C., Papakosta C., Bourantas C., Michalis L. K., Christos M., Foussas S., Adamopoulou E., Marketou M., Alotti N., Basa A. M., Vigh A., Preda I., Csoti E., Keltai M., Kerkovits G., Hendler A., Blatt A., Yakov B., Beyar R., Shefer A., Halon D., Bentzvi M., Avramovitch N., Bakst A., Saba K., Cafri C., Grosbard A., Sheva B., Margolis B., Suleiman K., Banai S., Meerkin D., Mosseri M., Guita P., Jabara R., Jafari J., Shitrit D. B., Ghasan D., Salameh D., Brezins M., van den Akker-Berman L., Guetta V., Hashomer T., Rozenman Y., Biagini A., Berti S., Ferrero M., Colombo A., Roccaforte R., Milici C., Scarpino L., Salvi A., Desideri A., Sabbadin D., Veneto C., Galassi A., Giuffrida G., Rognoni A., Vassanelli C., Paffoni P., Cioppa A., Rubino P., de Carlo M., Petronio A. S., Naccarella F., Saia F., Marzocchi A., Maranga S. S., Presbitero P., Valsecchi F., Esposito G., Santini N. M., Tubaro M., Erglis A., Narbute I., Kavoliuniene A., Zaliunas R., Navickas R., Luckute D., Subkovas E., Wagner D., Vermeer F., Lousberg A., Fransen H., Breeman A., Tebbe H., De Boer M. J., van der Wal M., Leenders C. M., Veerhoek M. J., Jansen C., Bijl M., Koppelaar C., den Linden V., Brons R., Widdershofen J. W. M. G., Broers H., Kontny F., Jonzon M., Wodniecki J., Tomasik A., Trusz-Gluza M., Nowak S., Ruzyllo W., Deptuch T., Marques J., Matias F., Madeira H., Oliveira J., Sargento L., Ionac A., Dragulescu I. S., Mut-Vitcu B., Maximov D., Dorobantu M., Apetrei E., Niculescu R., Petrescu V., Bucsa A., Deleanu D., Bucharest, Benedek I. S., Hintea T., Aronov D., Tikhomirova E., Kranjec I., Prokselj K., Kanic V., Sepetoglu A., Aytekin S., Aytekin V., Catakoglu A. B., Parlar H., Tufekcioglu S., Ozyedek Z., Baltali M., Kiziltan, Vukovic M., Neskovic A. N., Cardiology, Hordijk-Trion, M., Lenzen, M., Wijns, W., De Jaegere, P., Simoons, M. L., Scholte Op Reimer, W. J. M., Bertrand, M. E., Mercado, N., Boersma, E., Maier, W., Meier, B., Moris, C., Piscione, F., Sechtem, U., Sergeant, P., Stahle, E., Vos, J., Widimsky, P., Unger, F., Manini, M., Bramley, C., Laforest, V., Taylor, C., Del Gaiso, S., Huber, K., De Backer, G., Sirakova, V., Cerbak, R., Thayssen, P., Lehto, S., Blanc, J. -J., Delahaye, F., Kobulia, B., Zeymer, U., Cokkinos, D., Karlocai, K., Graham, I., Shelley, E., Behar, S., Maggioni, A., Grabauskiene, V., Deckers, J., Asmussen, I., Stepinska, J., Goncalves, L., Mareev, V., Riecansky, I., Kenda, M. F., Alonso, A., Lopez-Sendon, J. L., Rosengren, A., Buser, P., Okay, T., Sychov, O., Fox, K., Wood, D., Crijns, H., Mcgregor, K., Mulder, B., Priori, S., Ryden, L., Tavazzi, L., Vahanian, A., Vardas, P., Sarkisyan, K., Glogar, H. D., Frick, M., Pachinger, O., Zwick, R., Vrints, C., Van Hertbruggen, E., Vercammen, M., Sysmans, T., Schroeder, E., Domange, J., De Pril, H., De Vriese, J., Van Hecke, T., Legrand, V., Gillon, M. -F., Richardy, M., Doneux, P., Petrov, I., Jorgova, J., Starcevic, B., Eeckhout, E., Berger, A., Prudent, V., Camenzind, E., Masson, N., Zambartas, C., Kleanthous, H., Stellova, B., Aschermann, M., Simek, S., Kautzner, J., Karmazin, V., Svab, P., Indrak, J., Branny, M., Hladilova, K., Kala, P., Cappelen, H., Jensen, L. O., Gitt, A., Gehrke, K., am Rhein, L., Erbel, R., Gutersohn, A., Eggebrecht, H., Al Khani, M., Rosenberger, A., Vogelsberg, H., Klepzig, H., Schmidt, A., Silber, S., Mau, B., Leuner, C., Czyborra, K., Reuschling, C., Muno, E., Nauheim, B., Kleber, F., Rux, S., Saad, A., Elabady, M., Beiras, A. C., Fernandez, J. S., del Arno, F. N., Romo, A. I., Fernandez, J. M. C., Mayoreal, A. R., Rebanal, F. J. R., de la Borbolla, M. G., Chaparro, M., Brotons, C., Miralda, C. P., Vila i Perez, S. I., Aviles, F. F., de la Fuente Galan, L., Vinuela, P. T., de Torres, F. M., Mora, J., Rodriguez, I. S., Bustamante, I. P., Fernandez, P. L. S., Torrent, J. L. D., Gil, J. L. D., Perpinan, J., Motilla, V. P., Juango, M. S. A., Berjon-Reyero, J., Moreno, R. M., Guerrero, J. C. F., Savolainen, K., Syvanne, M., Cohen-Solal, A., Oboa, A. -S., Bassand, J. P., Espinosa, D. P., Jouet, V., Cedex, B., Montalescot, G., Gallois, V., Daubert, J. C., Clerc, J. M., Machecourt, J., Cottin, Y., Walker, D., Holland, F., Prosser, J., Muir, L., Barber, K., Cleland, J. G. F., Cook, J., Chapichadze, Z., Christos, I. S. A., Tsiavou, N., Chrysohoou, C., Manginas, A., Terrovitis, J., Kanakakis, J., Vavuranakis, M., Drakos, S., Farmakis, T., Samara, C., Papakosta, C., Bourantas, C., Michalis, L. K., Christos, M., Foussas, S., Adamopoulou, E., Marketou, M., Alotti, N., Basa, A. M., Vigh, A., Preda, I., Csoti, E., Keltai, M., Kerkovits, G., Hendler, A., Blatt, A., Yakov, B., Beyar, R., Shefer, A., Halon, D., Bentzvi, M., Avramovitch, N., Bakst, A., Saba, K., Cafri, C., Grosbard, A., Sheva, B., Margolis, B., Suleiman, K., Banai, S., Meerkin, D., Mosseri, M., Guita, P., Jabara, R., Jafari, J., Shitrit, D. B., Ghasan, D., Salameh, D., Brezins, M., van den Akker-Berman, L., Guetta, V., Hashomer, T., Rozenman, Y., Biagini, A., Berti, S., Ferrero, M., Colombo, A., Roccaforte, R., Milici, C., Scarpino, L., Salvi, A., Desideri, A., Sabbadin, D., Veneto, C., Galassi, A., Giuffrida, G., Rognoni, A., Vassanelli, C., Paffoni, P., Cioppa, A., Rubino, P., de Carlo, M., Petronio, A. S., Naccarella, F., Saia, F., Marzocchi, A., Maranga, S. S., Presbitero, P., Valsecchi, F., Esposito, G., Santini, N. M., Tubaro, M., Erglis, A., Narbute, I., Kavoliuniene, A., Zaliunas, R., Navickas, R., Luckute, D., Subkovas, E., Wagner, D., Vermeer, F., Lousberg, A., Fransen, H., Breeman, A., Tebbe, H., De Boer, M. J., van der Wal, M., Leenders, C. M., Veerhoek, M. J., Jansen, C., Bijl, M., Koppelaar, C., den Linden, V., Brons, R., Widdershofen, J. W. M. G., Broers, H., Kontny, F., Jonzon, M., Wodniecki, J., Tomasik, A., Trusz-Gluza, M., Nowak, S., Ruzyllo, W., Deptuch, T., Marques, J., Matias, F., Madeira, H., Oliveira, J., Sargento, L., Ionac, A., Dragulescu, I. S., Mut-Vitcu, B., Maximov, D., Dorobantu, M., Apetrei, E., Niculescu, R., Petrescu, V., Bucsa, A., Deleanu, D., Bucharest, Benedek, I. S., Hintea, T., Aronov, D., Tikhomirova, E., Kranjec, I., Prokselj, K., Kanic, V., Sepetoglu, A., Aytekin, S., Aytekin, V., Catakoglu, A. B., Parlar, H., Tufekcioglu, S., Ozyedek, Z., Baltali, M., Kiziltan, Vukovic, M., and Neskovic, A. N.

Subjects
Male, medicine.medical_specialty, Randomization, medicine.medical_treatment, Euro Heart Survey, Coronary Artery Disease, Revascularization, law.invention, Coronary artery disease, Randomized controlled trial, law, Internal medicine, Angioplasty, medicine, Humans, cardiovascular diseases, Angioplasty, Balloon, Coronary, Coronary Artery Bypass, CABG, Aged, Randomized Controlled Trials as Topic, business.industry, Coronary Artery Bypa, Patient Selection, PCI, Health Survey, Middle Aged, medicine.disease, Health Surveys, Surgery, Clinical trial, Stenosis, surgical procedures, operative, Clinical Trials, Phase III as Topic, Conventional PCI, Female, Cardiology and Cardiovascular Medicine, business, Human
Abstract

Aims: Revascularization in patients with coronary artery disease changed over the last two decades, favouring the number of patients treated by means of percutaneous coronary interventions (PCI) when compared with coronary artery bypass grafting (CABG). Many randomized controlled trials (RCTs) have been performed to compare these two competing revascularization techniques. Because of the strict enrolment criteria of RCTs in which highly selected patients are recruited, the applicability of the results may be limited in clinical practice. The current study evaluates to what extent patients in clinical practice were similar to those who participated in RCTs comparing PCI with CABG. Methods and results: Clinical characteristics and 1-year outcome of 4713 patients enrolled in the Euro Heart Survey on Coronary Revascularization were compared with 8647 patients who participated in 14 major RCTs, comparing PCI with CABG. In addition, we analysed which proportion of survey patients would have disqualified for trial participation (n = 3033, 64%), aiming at identifying differences between trial-eligible and trial-ineligible survey patients. In general, important differences were observed between trial participants and survey patients. Patients in clinical practice were older, more often had comorbid conditions, single-vessel disease, and left main stem stenosis when compared with trial participants. Almost identical differences were observed between trial-eligible and trial-ineligible survey patients. In clinical practice, PCI was the treatment of choice, even in patients who were trial-ineligible (46% PCI, 26% CABG, 28% medical). PCI remained the preferred treatment option in patients with multi-vessel disease (57% in trial-eligible and 40% in trial-ineligible patients, respectively, P < 0.001); yet, the risk profile of patients treated by PCI was better than that for patients treated either by CABG or by medical therapy. In the RCTs, there was no mortality difference between PCI and CABG. In clinical practice, however, we observed 1-year unadjusted survival benefit for PCI vs. CABG (2.9 vs. 5.4%, P < 0.001). Survival benefit was only observed in trial-ineligible patients (3.3 vs. 6.2%, P < 0.001). Conclusion: Many patients in clinical practice were not represented in RCTs. Moreover, only 36% of these patients were considered eligible for participating in a trial comparing PCI with CABG. We demonstrated that RCTs included younger patients with a better cardiovascular risk profile when compared with patients in everyday clinical practice. This study highlights the disparity between patients in clinical practice and patients in whom the studies that provide the evidence for treatment guidelines are performed. © The European Society of Cardiology 2006. All rights reserved.

Published
2006

36. Neuroimaging and Dissociative Disorders

Author

Staniloiu, Angelica, Vitcu, Irina, Markowitsch, Hans J., and Chaudhary, Vikas

Subjects
Depersonalization Disorder, Ganser syndrome, medicine.drug_class, Dissociative Amnesia, medicine.disease, Dissociative, Dissociative identity disorder, Dissociative disorder not otherwise specified, medicine, Dissociative disorders, Psychology, Conversion disorder, Clinical psychology
Abstract

Although they were for a while “dissociated” (Spiegel, 2006) from the clinical and scientific arena, dissociative disorders have in the last several years received a renewed interest among several groups of researchers, who embarked on the work of identifying and describing their underlying neural correlates. Dissociative disorders are characterized by transient or chronic failures or disruptions of integration of otherwise integrated functions of consciousness, memory, perception, identity or emotion. The DSM-IV-TR (2000) includes nowadays under the heading of dissociative disorders several diagnostic entities, such as dissociative amnesia and fugue, depersonalization disorder, dissociative identity disorder and dissociative disorder not otherwise specified (such as Ganser syndrome). In contrast to DSM-IV-TR, ICD-10 (1992) also comprises under the category of dissociative (conversion) disorder the entity of conversion disorder (with its various forms), which is in DSM-IV-TR (2000) captured under the heading of somatoform disorders (and probably will remain under the same heading in the upcoming DSM-V).

Published
2012

37. Side effects profile in humans of (11)C-(+)-PHNO, a dopamine D(2/3) agonist ligand for PET

Author

Sylvain Houle, Alvina Ng, Alan A. Wilson, Irina Vitcu, and Romina Mizrahi

Subjects
Agonist, medicine.diagnostic_test, Chemistry, medicine.drug_class, Stereochemistry, Ligand, Receptors, Dopamine D2, Receptors, Dopamine D3, Ligands, Positron emission tomography, Dopamine receptor D2, Positron-Emission Tomography, Pet ligand, Oxazines, medicine, Humans, Regression Analysis, Radiology, Nuclear Medicine and imaging, Selectivity, Receptor
Abstract

TO THE EDITOR: 11C-(+)-4-propyl-9-hydroxynaphthoxazine ((+)-PHNO) is a new PET ligand developed by our group. Binding assays show that (+)-PHNO displays high affinity and selectivity for the D2 receptor ( [1][1] ). Recently, it has been noted that 11C-(+)-PHNO has a preferential affinity and

Published
2010

40. First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study

Author

Ariel Graff, Matthäus Willeit, Nathalie Ginovart, Alan A. Wilson, Irina Vitcu, Pablo Rusjan, Philip Seeman, Sylvain Houle, and Shitij Kapur

Subjects
Agonist, Adult, Male, medicine.medical_specialty, Dextroamphetamine, medicine.drug_class, Globus Pallidus, chemistry.chemical_compound, ddc:616.89, Dopamine, Internal medicine, Oxazines, medicine, Radioligand, Humans, Amphetamine, Neurotransmitter, Corpus Striatum/diagnostic imaging/metabolism, Putamen/diagnostic imaging/metabolism, Globus Pallidus/diagnostic imaging/metabolism, Pharmacology, Dopamine Agonists/chemical synthesis, Chemistry, Dextroamphetamine/pharmacology, Putamen, Brain, Corpus Striatum, Oxazines/chemical synthesis, Psychiatry and Mental health, Endocrinology, Globus pallidus, Positron-Emission Tomography, Dopamine Agonists, Catecholamine, Caudate Nucleus/diagnostic imaging/metabolism, Female, Caudate Nucleus, Brain/diagnostic imaging/metabolism, medicine.drug
Abstract

Imaging the competition between D(2/3) radioligands and endogenous dopamine is so far the only way to measure dopamine release in the living human brain. The dopamine D(2) receptor exists in a high (D(2)(high)) and a low-affinity state for dopamine. Under physiological conditions, dopamine is expected to bind to D(2)(high) only. [(11)C]-(+)-4-propyl-9-hydroxynaphthoxazine ((+)-PHNO) is the first D(2/3) agonist radioligand for positron emission tomography (PET) imaging in humans. Since [(11)C]-(+)-PHNO is expected to bind preferentially to D(2)(high), it should be particularly vulnerable to competition with endogenous dopamine. Nine healthy subjects participated in two PET scans, one after administration of d-amphetamine and one after placebo. [(11)C]-(+)-PHNO PET test re-test variability was determined in 11 healthy subjects. Binding potentials (BPs) were calculated for caudate, putamen, ventral striatum, and globus pallidus. d-Amphetamine led to a significant decrease of [(11)C]-(+)-PHNO BPs in caudate (-13.2%), putamen (-20.8%), and ventral striatum (-24.9%), but not in globus pallidus (-6.5%). d-Amphetamine-induced displacement correlated with serum d-amphetamine levels in all regions but caudate. This is the first report on competition between endogenous dopamine and a D(2/3) agonist radioligand in humans. [(11)C]-(+)-PHNO PET might be a superior measure for release of endogenous dopamine than PET employing conventional D(2/3) antagonist radioligands.

Published
2007

41. Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response - a double-blind PET study in schizophrenia

Author

Robert B. Zipursky, Nathalie Ginovart, David C. Mamo, Irina Vitcu, Alan A. Wilson, Shitij Kapur, and Ofer Agid

Subjects
Male, Dyskinesia, Drug-Induced, Pyrrolidines, medicine.medical_treatment, Dopamine, Salicylamides, Haloperidol, Receptor, Serotonin, 5-HT2C, Prospective Studies, Antipsychotic drugs, Psychomotor Agitation, Raclopride, Middle Aged, Risperidone, Magnetic Resonance Imaging, Psychiatry and Mental health, Schizophrenia, Dopamine receptor, Olanzapine, Female, Schizophrenic Psychology, Psychology, Antipsychotic Agents, medicine.drug, Cognition -- Data processing, Adult, medicine.medical_specialty, Psychosis, Serotonin, Adolescent, Muscarinic Antagonists, Double-Blind Method, Dopamine receptor D2, Internal medicine, medicine, Humans, Antipsychotic, Benztropine, Psychiatric Status Rating Scales, Pharmacology, Receptors, Dopamine D2, Dopamine antagonist, medicine.disease, Prolactin, Neostriatum, Endocrinology, Positron-Emission Tomography, Dopamine Antagonists, Neuroscience
Abstract

Blockade of dopamine D2 receptors remains a common feature of all antipsychotics. It has been hypothesized that the extrastriatal (cortical, thalamic) dopamine D2 receptors may be more critical to antipsychotic response than the striatal dopamine D2 receptors. This is the first double-blind controlled study to examine the relationship between striatal and extrastriatal D2 occupancy and clinical effects. Fourteen patients with recent onset psychosis were assigned to low or high doses of risperidone (1 mg vs 4 mg/day) or olanzapine (2.5 mg vs 15 mg/day) in order to achieve a broad range of D2 occupancy levels across subjects. Clinical response, side effects, striatal ([11C]-raclopride-positron emission tomography (PET)), and extrastriatal ([11C]-FLB 457-PET) D2 receptors were evaluated after treatment. The measured D2 occupancies ranged from 50 to 92% in striatal and 4 to 95% in the different extrastriatal (frontal, temporal, thalamic) regions. Striatal and extrastriatal occupancies were correlated with dose, drug plasma levels, and with each other. Striatal D2 occupancy predicted response in positive psychotic symptoms (r=0.62, p=0.01), but not for negative symptoms (r=0.2, p=0.5). Extrastriatal D2 occupancy did not predict response in positive or negative symptoms. The two subjects who experienced motor side effects had the highest striatal occupancies in the cohort. Striatal D2 blockade predicted antipsychotic response better than frontal, temporal, and thalamic occupancy. These results, when combined with the preclinical data implicating the mesolimbic striatum in antipsychotic response, suggest that dopamine D2 blockade within specific regions of the striatum may be most critical for ameliorating psychosis in schizophrenia., peer-reviewed

Published
2007

42. BODY MASS INDEX AND GLYCAEMIC CONTROL IN PATIENTS WITH DIABETES MELLITUS: A CASE-CONTROL STUDY.

Author

Mut-Vitcu, Gabriela, Hudrea, Iuliana-Claudia, Moşteoru, Svetlana, Gaiţă, Laura, and Gaiţă, Dan

Subjects
*GLYCEMIC index, *BODY mass index, *DIABETES, *DISEASE management, *MEDICAL care
Abstract

Background and Aims: Recent studies have brought evidence on the connection between excess weight and suboptimal glycemic control for Diabetes Mellitus (DM) patients. The aim of this study was to evaluate the association between increased Body Mass Index (BMI) and the likelihood of having suboptimal glycemic control in patients with Type 1 and Type 2 Diabetes Mellitus. Materials and Methods: A case-control study was conducted on 662 patients suffering from Diabetes Mellitus and statistical analysis was performed in order obtain evidence associating BMI and poor glycaemic control. We defined as increased BMI, values >25 kg/m2 and a hemoglobin A1c (HbA1c) value >7% reflected suboptimal glycemic control. Results: 559 (84%) patients had HbA1c >7%. 550 (83 %) patients had a BMI >25 kg/m2. In case of HbA1c >7%, a BMI >25 kg/m2 was found in a number of 457 patients (82 %), whereas a normal BMI was present in 102 (18%) patients. For the HbA1c<7% cases, the number of patients associating BMI >25 kg/m2 was 93 (90%) and a normal BMI was present in 10 (10%) patients. BMI >25 kg/m2 was not associated with a higher probability of having above-target HbA1c values compared to patients with target HbA1c (OR 0.48, 95% CI: 0.24 to 0.95), with a statistically significant p <0.05. Conclusions: The findings revealed that although in case of suboptimal glycemic control, the number of patients who had a BMI >25 kg/m2 was significantly higher than the number of patients with a BMI < 25 kg/m2, a BMI above target was not associated with greater odds of having HbA1c higher than the standard 7% level, compared to individuals with normal HbA1c levels. The results emphasize that a multitude of factors are involved in the process of achieving a targeted glycemic control and a stepped-care approach should be considered for optimum management of Diabetes Mellitus. [ABSTRACT FROM AUTHOR]

Published
2017
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43. High-resolution tunable mid-infrared spectrometer based on difference-frequency generation in AgGaS2

Author

A. Vitcu, James R. Drummond, Roman Wehr, Richard Ciurylo, and A. David May

Subjects
Dye laser, Materials science, Spectrometer, business.industry, Infrared, Materials Science (miscellaneous), Industrial and Manufacturing Engineering, Spectral line, Rhodamine 6G, Crystal, Laser linewidth, chemistry.chemical_compound, Optics, chemistry, Optoelectronics, Business and International Management, business, Line (formation)
Abstract

We have built a high-resolution and high-signal-to-noise ratio spectrometer for line shape studies of greenhouse gases in the mid infrared. The infrared radiation is generated in a AgGaS2 nonlinear crystal by the well-known difference-frequency method. The choice of crystal is explained, and a brief literature review is presented. With two tunable dye lasers and a type I, 90 degrees phase-matching geometry, the infrared is continuously tunable from 7 to 9 microm when Rhodamine 6G and Sulforhodamine 640 dyes are used. The total infrared power exceeds 30 nW and is limited by both the damage threshold and thermal loading of the crystal. Phase-sensitive detection allows us to reach signal-to-noise ratios in excess of 3500:1 while maintaining an instrumental linewidth of 1.5 MHz. However, we show that the spectrometer may be used to measure the positions of spectral lines within +/-400 kHz.

Published
2004

44. Dynamic spectroscopic measurements of the temperature and pressure cycles in a MOPITT pressure modulator cell

Author

Roman Ciuryło, A. Vitcu, Richard Wehr, James R. Drummond, and Eamonn McKernan

Subjects
Materials science, business.industry, Materials Science (miscellaneous), Analytical chemistry, Temperature measurement, Industrial and Manufacturing Engineering, MOPITT, Spectral line, law.invention, Troposphere, Pressure measurement, Optics, law, Temporal resolution, Radiometry, Business and International Management, business, Remote sensing, Line (formation)
Abstract

The temperature and pressure cycles inside a pressure modulator cell (PMC) of the type used for gas-correlation radiometry aboard the Measurements of Pollution in the Troposphere (MOPITT) satellite instrument have been determined from dynamic measurements of the spectral line shapes of the R(0) and R(18) transitions in the fundamental vibrational-rotational band of carbon monoxide. The line strengths and linewidths were used to calculate the temperature and pressure, respectively, with a temporal resolution of approximately 200 micros, or 1/100 of a PMC cycle. The results are compared with a thermodynamic box model.

Published
2003

45. Laser-plasma harmonics with high-contrast pulses and designed prepulses

Author

H. Higaki, S. P. Le Blanc, G. Kulcsar, A. Vitcu, R. Wagner, Robin Marjoribanks, L. Zhao, F.W. Budnik, Anatoly Maksimchuk, Michael C. Downer, and Donald P. Umstadter

Subjects
Chemistry, business.industry, Physics::Optics, Plasma, Breakup, Laser, law.invention, Harmonic spectrum, Optics, Physics::Plasma Physics, law, Harmonics, Picosecond, High harmonic generation, Plasma diagnostics, business
Abstract

One aspect of the complexity of mid- and high-harmonic generation in high-intensity laser-plasma interactions is that nonlinear hydrodynamics is virtually always folded together with the nonlinear optical conversion process. We have partly dissected this issue in picosecond and subpicosecond interactions with preformed plasma gradients, imaging and spectrally resolving low- and mid-order harmonics. We describe spatial breakup of the picosecond beam in preformed plasmas, concomitant broadening and breakup of the harmonic spectrum, presumably through self-phase modulation, together with data on the sensitivity of harmonics production efficiency to the gradient or extent of preformed plasma. Lastly, we show preliminary data of regular Stokes-like and anti-Stokes-like satellites to the harmonics, accompanied by modification of the forward-scattered beam.

Published
1998

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