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Your search keyword '"Varley, J.M."' showing total 7 results
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7 results on '"Varley, J.M."'

1. Identification of recurrent regions of chromosome loss and gain in vestibular schwannomas using comparative genomic hybridisation

Author

Warren, C., James, L.A., Ramsden, R.T., Wallace, A., Baser, M.E., Varley, J.M., and Evans, D.G.

Subjects
Schwann cells -- Genetic aspects -- Physiological aspects -- Health aspects -- Analysis -- Research, Gene expression -- Physiological aspects -- Research -- Genetic aspects -- Analysis -- Health aspects, Tumors -- Genetic aspects -- Health aspects -- Care and treatment -- Research, Genetic research -- Analysis -- Physiological aspects -- Genetic aspects -- Health aspects, Patients -- Genetic aspects -- Health aspects -- Care and treatment -- Physiological aspects -- Research -- Analysis, Medical genetics -- Research -- Health aspects -- Analysis -- Physiological aspects, Chromosomes -- Genetic aspects -- Analysis -- Health aspects -- Research -- Physiological aspects, Health, Care and treatment, Physiological aspects, Analysis, Research, Genetic aspects, Health aspects
Abstract

J Med Genet 2003;40:802-806 Background: Schwannomas are benign tumours of the nervous system that are usually sporadic but also occur in the inherited disorder neurofibromatosis type 2 (NF2). The NF2 [...]

Published
2003

2. Low rate of TP53 germline mutations in breast cancer/sarcoma families not fulfilling classical criteria for Li-Fraumeni syndrome. (Letter to JMG)

Author

Evans, D.G.R., Birch, J.M., Thorneycroft, M., McGown, G., Lalloo, F., and Varley, J.M.

Subjects
Gene mutations -- Research -- Genetic aspects, Sarcoma -- Genetic aspects -- Research, Li-Fraumeni syndrome -- Genetic aspects -- Research, Cancer in children -- Genetic aspects -- Research, Breast cancer -- Genetic aspects -- Research, Health, Genetic aspects, Research
Abstract

Breast cancer and sarcoma are key components of Li-Fraumeni syndrome (LFS). (1-6) Sarcoma, particularly childhood osteosarcoma or rhabdomyosarcoma in addition to childhood adrenocortical carcinoma (ACC), is the strongest predictor of [...]

Published
2002

5. Structural rearrangement of the...

Author

T'Ang, A. and Varley, J.M.

Subjects
*CANCER research
Abstract

Presents recent research of the structural rearrangement of the retinoblastoma gene in human breast carcinoma. Research; Conclusions.

Published
1988
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6. Somatic glypican 3 (GPC3) mutations in Wilms' tumour.

Author

White, G.R.M., Kelsey, A.M., Varley, J.M., and Birch, J.M.

Subjects
NEPHROBLASTOMA, ANTIBODY diversity, POLYSACCHARIDES, RESEARCH, GENETIC mutation, RESEARCH methodology, GENETIC polymorphisms, EVALUATION research, DNA probes, COMPARATIVE studies, KIDNEY tumors, POLYMERASE chain reaction
Abstract

Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development. [ABSTRACT FROM AUTHOR]

Published
2002
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