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102 results on '"Valentino, L. A."'

1. Molecular pathogenesis and heterogeneity in type 3 VWD families in U.S. Zimmerman program

Author

Christopherson, Pamela A., Haberichter, Sandra L., Flood, Veronica H., Perry, Crystal L., Sadler, Brooke E., Bellissimo, Daniel B., Di Paola, Jorge, Montgomery, Robert R., Abshire, T, Weiler, H, Lillicrap, D, James, P, O’Donnell, J, Ng, C, Bennett, C, Sidonio, R, Manco‐Johnson, M, Journeycake, J, Zia, A, Lusher, J, Rajpurkar, M, Shapiro, A, Lentz, S, Gill, J, Leissinger, C, Ragni, M, Tarantino, M, Roberts, J, Hord, J, Strouse, J, Ma, A, Valentino, L, Boggio, L, Sharathkumar, A, Gruppo, R, Kerlin, B, Kulkarni, R, Green, D, Hoots, K, Brown, D, Mahoney, D, Mathias, L, Bedros, A, Diamond, C, Neff, A, DiMichele, D, Giardina, P, Cohen, A, Paidas, M, Werner, E, Matsunaga, A, Shafer, F, Konkle, B, Cuker, A, Kouides, P, and Stein, D

Published
2022
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2. Recent Advances in the Treatment of Hemophilia: A Review

Author

Marchesini E, Morfini M, and Valentino L

Subjects
replacement therapy, adverse events, pharmacokinetics, extended half-life concentrates, non-replacement therapy, gene therapy, Medicine (General), R5-920
Abstract

Emanuela Marchesini,1 Massimo Morfini,2 Leonard Valentino3,4 1Hemophilia Centre, SC Vascular and Emergency Department, University of Perugia, Perugia, Italy; 2Italian Association of Haemophilia Centres (AICE), Naples, Italy; 3National Hemophilia Foundation, New York, NY, USA; 4Rush University, Chicago, IL, USACorrespondence: Massimo Morfini via Dello Statuto N.1- I-50129, Firenze, ItalyTel +39 348 2306928Fax +39 055-4732 18Email drmassimomorfini@gmail.comAbstract: Progress in hemophilia therapy has been remarkable in the first 20 years of the third millennium, but the innovation began with the description the fractionation of plasma in 1946. The first concentrates followed the discovery of FVIII in the cryoprecipitate of frozen plasma and FIX in the supernatant in the early 1960s, which led to the initial attempts at replacement therapy. Unfortunately, the lack of screening methods for viral pathogens resulted in people with hemophilia (PWH) receiving concentrates contaminated by hepatitis A virus, hepatitis C virus, and human immunodeficiency virus, as these concentrates were made from large industrial pools of plasma derived from thousands of donors. Fortunately, by 1985, viral screening methods and proper virucidal techniques were developed that made concentrates safe. Increasingly pure products followed the introduction of chromatography steps with monoclonal antibodies in the production process. The problem of immunogenicity of exogenously administered concentrates has not yet had a complete solution. The development of alloantibodies against FVIII in about 25– 35% of PWH is the most serious adverse effect of replacement therapy. The next major advance followed the cloning of the F8 gene and later the F9 genes, which paved the way to produce concentrates of factors obtained by the recombinant DNA technology. The injected FVIII and FIX molecules had a relatively short circulating half-life in the plasma of people with hemophilia A and B, approximately 12 and 18 hours, respectively. The ability to prolong the plasma half-life and extend the interval between injections followed the application of methods to conjugate the factor molecule with the fragment crystallizable of IgG1 or albumin or by adding polyethylene glycol, which has led to an increase in the half-life of concentrates, especially for rFIX. The next frontier in hemophilia therapy is the application of durable and potentially curative therapies such as with gene addition therapy. Experiments in hemophilia B have demonstrated durable responses. Unfortunately, the results with gene therapy for hemophilia A have not been as remarkable and the durability must still be demonstrated. Nonetheless, the long-term safety, predictability, durability, and efficacy of gene therapy for hemophilia A and B remain an open question. At present, only healthy adult PWH have been enrolled in gene therapy clinical trials. The application of gene therapy to children and those with pre-existing antibodies against the delivery vector must also be studied before this therapy becomes widespread.Keywords: replacement therapy, adverse events, pharmacokinetics, extended half-life concentrates, non-replacement therapy, gene therapy

Published
2021

3. Laboratory variability in the diagnosis of type 2 VWD variants

Author

DiGiandomenico, Stefanie, Christopherson, Pamela A., Haberichter, Sandra L., Abshire, Thomas C., Montgomery, Robert R., Flood, Veronica H., Valentino, L., Abshire, T., Dunn, A., Bennett, C., Lusher, J., Rajpurkar, M., Hoots, W.K., Brown, D., Shapiro, A., Paola, J. Di, Lentz, S., Gill, J., Leissinger, C., Ragni, M., Hord, J., Manco‐Johnson, M., Ma, A., Boggio, L., Sharathkumar, A., Gruppo, R., Kerlin, B., Journeycake, J., Kulkarni, R., Mahoney, D, Mathias, L., Bedros, A., Diamond, C., Neff, A., Paroskie, A., DiMichele, D., Giardina, P., Cohen, A., Paidas, M., Werner, E., Matsunaga, A., Singer, T., Tarantino, M., Roberts, J., Shafer, F., Konkle, B., Cuker, A., Kouides, P., Stein, D., Lillicrap, D., and James, P.

Published
2021
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4. PB0191 myGTR: A Patient Engagement Tool from the World Federation of Hemophilia Gene Therapy Registry

Author

Youttananukorn, T., primary, Konkle, B., additional, Coffin, D., additional, Naccache, M., additional, Clark, C., additional, George, L., additional, Iorio, A., additional, Miesbach, W., additional, Noone, D., additional, Peyvandi, F., additional, Pipe, S., additional, Recht, M., additional, Skinner, M., additional, Valentino, L., additional, Mahlangu, J., additional, and Pierce, G., additional

Published
2023
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5. OC 20.5 The WFH Gene Therapy Registry: A Collaborative Approach Towards a Global Resource for the Long-Term Follow-up of People with Hemophilia Treated with Gene Therapy

Author

Konkle, B., primary, Coffin, D., additional, Naccache, M., additional, Youttananukorn, T., additional, Clark, C., additional, George, L., additional, Iorio, A., additional, Miesbach, W., additional, Noone, D., additional, Peyvandi, F., additional, Pipe, S., additional, Recht, M., additional, Skinner, M., additional, Valentino, L., additional, Mahlangu, J., additional, and Pierce, G., additional

Published
2023
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6. PB0649 Results from the RESIST Study for Tolerance Induction in Patients with Poor Prognosis for ITI Success

Author

Koenigs, C., primary, Schmidt, A., additional, Salzmann-Manrique, E., additional, Orlowski, A., additional, Stichel, D., additional, Carcao, M., additional, Chan, A., additional, Guerrera, M., additional, Jeng, M., additional, Klaassen, R., additional, Kulkarni, R., additional, Rajpurkar, M., additional, Reiss, U., additional, Sanders, J., additional, Santagostino, E., additional, Valentino, L., additional, and Ewing, N., additional

Published
2023
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9. Towards the evaluation of defects in MoS2 using cryogenic photoluminescence spectroscopy

Author

Jana Vejpravova, Tim Verhagen, Golam Haider, Martin Kalbac, and Valentino L. P. Guerra

Subjects
Materials science, Photoluminescence, business.industry, Graphene, 02 engineering and technology, Substrate (electronics), Chemical vapor deposition, 021001 nanoscience & nanotechnology, 01 natural sciences, law.invention, symbols.namesake, law, 0103 physical sciences, Monolayer, symbols, Optoelectronics, General Materials Science, 010306 general physics, 0210 nano-technology, Spectroscopy, Raman spectroscopy, business, Raman scattering
Abstract

Characterization of the type and density of defects in two-dimensional (2D) transition metal dichalcogenides (TMDs) is important as the nature of these defects strongly influences the electronic and optical properties of the material, especially its photoluminescence (PL). Defect characterization is not as straightforward as it is for graphene films, where the D and D' Raman scattering modes easily indicate the density and type of defects in the graphene layer. Thus, in addition to the Raman scattering analysis, other spectroscopic techniques are necessary to perform detailed characterization of atomically thin TMD layers. We demonstrate that PL spectroscopy performed at liquid helium temperatures reveals the key fingerprints of defects in TMDs and hence provides valuable information about their origin and concentration. In our study, we address defects in chemical vapor deposition (CVD)-grown MoS2 monolayers. A significant difference is observed between the as-grown monolayers compared with the CVD-grown monolayers transferred onto a Si/SiO2 substrate, which contain extra defects due to the transfer process. We demonstrate that the temperature-dependent Raman and PL micro-spectroscopy techniques enable disentangling the contributions and locations of various defect types in TMD systems.

Published
2020
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10. Complications of Methylene Blue Dye in Breast Surgery: Case Reports and Review of the Literature

Author

FJ Reyes, MB Noelck, C Valentino, L Grasso-LeBeau, JE Lang

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: Methylene blue dye has been used worldwide successfully with few complications in breast surgery. We present two different complications involving methylene blue: 1) skin and parenchymal necrosis when dye was injected in a subdermal fashion and 2) Mycoplasma infection caused by contaminated methylene blue in breast reduction surgery.Methods: We present two cases seen at the University of Arizona during 2008 and referred to a breast surgeon for management. We evaluated and managed complications of methylene blue dye injected by 2 referring surgeons for different indications. A review of the literature was performed.Results: The first case is a 67 year old female diagnosed with infiltrating ductal carcinoma of the left breast for which she was treated by her initial surgeon with left segmental mastectomy and sentinel node biopsy. The operating surgeon injected methylene blue in a subareolar subdermal fashion (distant from the primary tumor); unfortunately the patient suffered skin and breast necrosis requiring multiple surgical debridements and finally achieving delayed primary closure. The second case is a 45 year old female with infiltrating lobular carcinoma with a history of Mycoplasma infection secondary to methylene blue injected for breast reduction surgery. She required multiple debridements and had granulomas masquerading as cancer on MRI that confounded her extent of disease.Conclusions: The use of methylene blue dye in breast surgery is not without risk. In both cases methylene blue was responsible for complications requiring surgical debridement for local wound problems. In each case severe necrosis and infection were present. Methylene blue may cause not only significant morbidity, but may also produce cosmetically unsatisfactory results.

Published
2011

12. Reversible Lectin Binding to Glycan-Functionalized Graphene

Author

Koukalová, Tereza, primary, Kovaříček, Petr, additional, Bojarová, Pavla, additional, Guerra, Valentino L. P., additional, Vrkoslav, Vladimír, additional, Navara, Lukáš, additional, Jirka, Ivan, additional, Cebecauer, Marek, additional, Křen, Vladimír, additional, and Kalbáč, Martin, additional

Published
2021
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13. The interview issue

Author

Valentino L. Zullo and Vera J. Camden

Subjects
Literature and Literary Theory, Visual Arts and Performing Arts, business.industry, media_common.quotation_subject, Cartoonist, media_common.cataloged_instance, Art, Comics, business, Visual arts, media_common
Abstract

‘The Interview Issue’ marks the first time the Journal of Graphic Novels and Comics has dedicated an entire issue to the voice of the cartoonist. When we were asked to become American Editors of th...

Published
2021
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14. Graphene-enhanced Raman scattering on single layer and bilayers of pristine and hydrogenated graphene

Author

Valentino L. P. Guerra, Václav Valeš, Martin Kalbac, and Karolina Drogowska-Horná

Subjects
Materials science, lcsh:Medicine, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Molecular physics, Article, law.invention, Rhodamine, symbols.namesake, chemistry.chemical_compound, Nanoscience and technology, law, lcsh:Science, Multidisciplinary, Graphene, Bilayer, lcsh:R, Doping, 021001 nanoscience & nanotechnology, Copper, 0104 chemical sciences, chemistry, symbols, lcsh:Q, 0210 nano-technology, Raman spectroscopy, Bilayer graphene, Raman scattering
Abstract

Graphene-enhanced Raman scattering (GERS) on isotopically labelled bilayer and a single layer of pristine and partially hydrogenated graphene has been studied. The hydrogenated graphene sample showed a change in relative intensities of Raman bands of Rhodamine 6 G (R6G) with different vibrational energies deposited on a single layer and bilayer graphene. The change corresponds qualitatively to different doping of graphene in both areas. Pristine graphene sample exhibited no difference in doping nor relative intensities of R6G Raman peaks in the single layer and bilayer areas. Therefore, it was concluded that strain and strain inhomogeneities do not affect the GERS. Because of analyzing relative intensities of selected peaks of the R6G probe molecules, it is possible to obtain these results without determining the enhancement factor and without assuming homogeneous coverage of the molecules. Furthermore, we tested the approach on copper phtalocyanine molecules.

Published
2020
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15. Towards the evaluation of defects in MoS2 using cryogenic photoluminescence spectroscopy

Author

Tim Verhagen, Valentino L. P. Guerra, Golam Haider, Martin Kalbac, and Jana Vejpravova

Abstract

Characterization of the type and density of defects in two-dimensional (2D) transition metal dichalcogenides (TMDs) is important as the nature of these defects strongly influences the electronic and optical properties of the material, especially its photoluminescence (PL). Defect characterization is not as straightforward as it is for graphene films, where the D and D’ Raman scattering modes easily indicate the density and type of defects in the graphene layer. Thus, in addition to the Raman scattering analysis, other spectroscopic techniques are necessary to perform detailed characterization of atomically thin TMD layers. We demonstrate that PL spectroscopy performed at liquid helium temperatures reveals the key fingerprints of defects in TMDs and hence provides valuable information about their origin and concentration. In our study, we address defects in chemical vapor deposition (CVD)-grown MoS2 monolayers. A significant difference is observed between the as-grown monolayers compared with the CVD-grown monolayers transferred onto a Si/SiO2 substrate, which contain extra defects due to the transfer process. We demonstrate that the temperature-dependent Raman and PL micro-spectroscopy techniques enable disentangling the contributions and locations of various defect types in TMD systems.

Published
2019

32. Selective self-assembly and light emission tuning of layered hybrid perovskites on patterned graphene

Author

Jana Vejpravova, Andrea Listorti, Václav Valeš, Tim Verhagen, Petr Kovaříček, Silvia Colella, Martin Kalbac, Karolina Drogowska, Valentino L. P. Guerra, Lukáš Horák, Guerra, Valentino L P, Kovaříček, Petr, Valeš, Václav, Drogowska, Karolina, Verhagen, Tim, Vejpravova, Jana, Horák, Lukáš, Listorti, Andrea, Colella, Silvia, and Kalbáč, Martin

Subjects
Materials science, Fabrication, Photoluminescence, Graphene, business.industry, Heterojunction, 02 engineering and technology, Substrate (electronics), 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, law.invention, law, Optoelectronics, General Materials Science, Light emission, Self-assembly, 0210 nano-technology, business, Perovskite (structure)
Abstract

The emission of light in two-dimensional (2-D) layered hybrid organic lead halide perovskites, namely (R-NH3)2PbX4, can be effectively tuned using specific building blocks for the perovskite formation. Herein this behaviour is combined with a non-covalent graphene functionalization allowing excellent selectivity and spatial resolution of the perovskite film growth, promoting the formation of hybrid 2-D perovskite : graphene heterostructures with uniform coverage of up to centimeter scale graphene sheets and arbitrary shapes down to 5 μm. Using cryo-Raman microspectroscopy, highly resolved spectra of the perovskite phases were obtained and the Raman mapping served as a convenient spatially resolved technique for monitoring the distribution of the perovskite and graphene constituents on the substrate. In addition, the stability of the perovskite phase with respect to the thermal variation was inspected in situ by X-ray diffraction. Finally, time-resolved photoluminescence characterization demonstrated that the optical properties of the perovskite films grown on graphene are not hampered. Our study thus opens the door to smart fabrication routes for (opto)-electronic devices based on 2-D perovskites in contact with graphene with complex architectures.

Published
2018

34. Implications of TiO2 surface functionalization on polycrystalline mixed halide perovskite films and photovoltaic devices

Author

Davide Altamura, Roberto Giannuzzi, Aurora Rizzo, Silvia Colella, Andrea Listorti, Vanira Trifiletti, Giuseppe Gigli, Giovanna Pellegrino, Guglielmo G. Condorelli, Cinzia Giannini, Valentino L. P. Guerra, Guerra, V, Altamura, D, Trifiletti, V, Colella, S, Listorti, A, Giannuzzi, R, Pellegrino, G, Condorelli, G, Giannini, C, Gigli, G, Rizzo, A, Guerra, Valentino L. P., Altamura, Davide, Trifiletti, Vanira, Colella, Silvia, Listorti, Andrea, Giannuzzi, Roberto, Pellegrino, Giovanna, Condorelli, Guglielmo Guido, Giannini, Cinzia, Gigli, Giuseppe, and Rizzo, Aurora

Subjects
Materials science, Renewable Energy, Sustainability and the Environment, business.industry, Chemistry (all), Photovoltaic system, Halide, giwaxs, Nanotechnology, General Chemistry, law.invention, photovoltaic, law, Surface modification, Optoelectronics, General Materials Science, Materials Science (all), Crystallite, Thin film, Crystallization, business, Layer (electronics), perovskite, Perovskite (structure)
Abstract

We exploit TiO2 surface functionalization as a tool to induce the crystallization process of CH3NH3PbI3−xClx perovskite thin films resulting in a reduction of the degree of orientation of the (110) crystallographic planes. Notably, the variation of the film crystalline orientational order does not affect the photovoltaic performances of the perovskite-based devices, whose efficiency remains mostly unchanged. Our findings suggest that other factors are more significant in determining the device efficiency, such as the non-homogenous coverage of the TiO2 surface causing charge recombination at the organic/TiO2 interface, defect distribution on the perovskite bulk and at the interfaces, and transport in the organic or TiO2 layer. This observation represents a step towards the comprehension of the perovskite film peculiarities influencing the photovoltaic efficiency for high performance devices.

Published
2015
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36. Strategies for preventing group B streptococcal infections in newborns: A nation-wide survey of Italian policies

Author

Tzialla, C, berardi, A, farina, C, clerici, P, borghesi, A, viora, E, scollo, P, stronati, M, Task Force for group B streptococcal infections for the Italian Society of Neonatology including Stival, G, barbaglia, Ma, guala, A, giunta, E, parola, L, grossignani, Mr, perri, P, tubaldi, L, alletto, G, daidone, S, flacco, V, dani, C, sterpa, A, rapisardi, G, elicio, Mr, faldella, G, capretti, Mg, messner, H, bandiera, M, achille, C, azzali, A, montrasio, G, mariani, S, galvagno, G, giacosa, E, de Angelis, F, spandrio, M, serra, A, garofalo, F, perona, A, porcelli, F, ferrero, F, De Franco, S, paollilo, P, picone, S, besana, R, varisco, T, farina, M, memo, L, nicolini, G, lietti, D, Di Chiara, G, rottoli, A, Bonabitacola, T, Cortis, E, Neri, E, Martinelli, S, Ilardi, L, Rondanini, Gf, Calzi, P, Gatta, A, Quntadamo, Pa, Ivaldi, M, Terenzani, L, Di Lascio, N, Travaglio, Md, Vetrano, G, Furcolo, G, Vitacco, V, Intini, C, Frigerio, M, Stroppiana, P, Policicchio, G, Mesirca, P, Gianino, P, Audenio, E, Paludetto, R, Raimondi, F, Pugliese, A, Valentino, L, Nosari, N, Marchesano, G, Chirico, G, Bellù, R, Menchini, M, Poletti, A, E T, Vacchiano, Pinto, L, E D, Perri, Coppola, R, Perini, R, Vetrella, A, De Luca, G, Lista, G, Cavigioli, F, Bettinelli, A, Massironi, E, Franco, C, Bernardo, L, Poli, S, Palladini, M, Tota, V, Spadavecchia, F, Zuccotti, Gv, Pogliani, L, Bracaglia, G, Mancini, Al, Zocco, F, Iozzia, G, Auriemma, A, Teani, M, Mangilli, G, Tempra, Am, Di Terlizi, L, Bottino, R, Salvi, C, Fortunato, V, Musaico, R, Gargantini, G, Carrera, G, Magaldi, R, Taurino, L, D'Onofrio, Am, Buffone, E, Tempera, A, Agosti, M, Garzia, P, Mosca, F, Pugni, L, Tagliabue, P, Colombo, C, Demi, M, Picco, G, Carlucci, A, Zorzi, G, Padula, D, Cardone, Ml, Buonocore, G, Muraca, Mc, Boldrini, A, Ciantelli, M, Lanari, M, Serra, L, Felici, L, Banderalli, G, Brambilla, C, Dall'Agnola, A, Viviani, E, Zonca, Mc, Licardi, G, Chiara, A, Ancora, G, Papa, I, Gancia, P, Pomero, G, Deloglu, A, Villani, P, Mussini, P, Canidio, E, Migliavacca, D, Di Fabio, S, Cipollone, I, Biasucci, G, Rubbi, P, Piepoli, M, Guastaferro, N, Infriccioli, F, Bertino, E, Perathoner, C, Parmigiani, S, Suriano, G, Ianniello, C, Biasini, A, Azzalli, M, Timpani, G, Barresi, S, Caoci, G, Ciccotti, R, De Curtis, M, Natale, F, Finocchi, M, Haass, C, Milillo, F, Lucieri, S, Guercio, E, Canepa, Sa, Scozia, G, Antonucci, R, Limongelli, O, Macciò, S, Mongelli, F, Colonna, F, Dragovic, D, Calipa, Mt, Cohen, A, Moresco, L, Italian Society of Obstetricians and Gynecologists including La Spina, R, Ruggeri, R, Luehwink, A, Brattoli, M, Fedi, A, Lacchi, L, Ettore, G, Pappalardo, E, Conoscenti, G, Zeni, B, Spellecchia, D, Favretti, L, Spagna, L, Zaglio, S, Bresciani, D, Bandini, A, Mancini, R, Mustoni, P, Dodero, D, Grimaldi, M, Di Mario, M, Migliorini, P, Kemeny, A, Anastasio, Ps, Riccardi, T, Maggino, T, Cerri, G, Puggina, P, Marconi, Am, Morgia, S, Bellia, G, D'Anna, Mr, Catania, M, Bacchi Modena, A, Franchi, L, Calonaci, N, Schettini, S, Paradiso, R, Saccucci, P, Ioppi, M, Zorzi, M, Stellin, G, Patacchiola, F, Carrata, L, Bassini, D, San Marco, L, Todros, T, Tibadi, C, Liborio, M, Italian Association of Clinical Microbiologists including Laricchia, R, Tauro, L, Ferrara, F, Nuara, C, Ghiraldi, E, Molinari, F, Comessatti, A, Rocchetti, A, Di Matteo, L, Miconi, V, Calvi, P, Pernigotti, A, Fabozzi, F, Micca, G, Monticone, G, Sarti, M, Da Rin, G, Zoppelletto, M, Modolo, E, Landini, Mp, Furlini, G, Galluppi, E, Pagani, E, Aschbacher, R, Innocenti, P, Bresolin, N, Raggi, Me, Bonfanti, C, De Francesco, M, Santer, P, Griessmaier, A, De Francesco, D, Pirali, A, Prasciolu, C, Usai, F, Cuzzone, G, Scutellà, M, Tramacere, P, Fossati, D, Piaserico, G, Bordignon, G, Sciacca, A, Di Vincenzo, F, Imbriani, A, Melotti, D, Catanoso, G, Rivetti, I, Neri, G, Bruno, R, Bacelle, L, Sartore, P, Giana, G, Sala, E, Giraldi, C, Cavalcanti, P, Perugini, M, Perugini, A, Ginardi, C, Maritano, D, Ferrini, A, Bonettini, A, Avanzini, A, Gasperoni, S, Pieretti, B, Montanari, E, Carillo, C, Rossi, Mr, Laureti, A, Baldoni, Ml, Serra, D, Melioli, G, Bandettini, R, Oneto, F, Colla, R, Storchi Incerti, S, Lanzini, F, Pauri, P, Tili, E, Leone, Ra, Verdastro, G, Megha, M, Luzzaro, F, Conti, A, Busulini, L, Mirri, P, Diodati, R, Vettori, C, Pittalis, S, Anesi, A, Fiore, A, Goglia, L, Vitullo, E, Sinno, A, Platzgummer, S, Spitaler, C, Trabucchi, Mc, Besozzi, M, Cesana, E, Inghilleri, G, Grosso, S, D'Angelo, R, Fogato, E, Lavarda, F, Ortisi, G, Clementi, M, Cichero, P, Rumpianesi, F, Venturelli, C, Mortillaro, F, Daffara, S, Catania, Mr, Iula, D, Andreoni, S, Politi, A, Agostinelli, C, Paparella, C, Capozzi, D, Notaris, P, Bistoni, F, Mencacci, A, Valentini, M, Filippetti, A, Confalonieri, M, Novarese, O, Bonini, F, Salamone, D, Camporese, A, De Rosa, R, Casprini, P, Degl'Innocenti, R, Giordano, R, Allù, Mt, Zanella, D, Malandrino, M, Tronci, M, Valmarin, M, Leonetti, G, Falco, S, Meledandri, M, Ballardini, M, Spanò, A, Cava, Mc, Mascellino, Mt, Schinella, M, Gualdi, P, Casari, E, Scattolo, N, Motta, C, Perfetti, C, Bassano, M, Cera, G, Iafisco, P, Mura, I, Palmieri, A, Migliardi, M, Ferlini, M, Grandi, G, Giardini, F, Albano, F, Latino, M, Ferrero, Mp, Bellizia, L, Russolo, M, Russolo, S, Pesenti, A, Fasano, Ma, Previato, S, Radillo, O, Busetti, M, Ferrari, P, Siderini, V, Puzzolante, L, Scarparo, C, Arzese, A, Cappuccia, N, Lodolo, L, Delledonne, L, Gramoni, A, Maiolo, V, Gheller, A, Spadaro, S, Balzaretti, M, Tzialla, C., Berardi, A., Farina, C., Clerici, P., Borghesi, A., Viora, E., Scollo, P., Stronati, M., Stival, G., Barbaglia, M. A., Guala, A., Giunta, E., Parola, L., Grossignani, M. R., Perri, P., Tubaldi, L., Alletto, G., Daidone, S., Flacco, V., Dani, C., Sterpa, A., Rapisardi, G., Elicio, M. R., Faldella, G., Capretti, M. G., Messner, H., Bandiera, M., Achille, C., Azzali, A., Montrasio, G., Mariani, S., Galvagno, G., Giacosa, E., de Angelis, F., Spandrio, M., Serra, A., Garofalo, F., Perona, A., Porcelli, F., Ferrero, F., De Franco, S., Paollilo, P., Picone, S., Besana, R., Varisco, T., Farina, M., Memo, L., Nicolini, G., Lietti, D., Di Chiara, G., Rottoli, A., Bonabitacola, T., Cortis, E., Neri, E., Martinelli, S., Ilardi, L., Rondanini, G. F., Calzi, P., Gatta, A., Quntadamo, P. A., Ivaldi, M., Terenzani, L., Di Lascio, N., Travaglio, M. D., Vetrano, G., Furcolo, G., Vitacco, V., Intini, C., Frigerio, M., Stroppiana, P., Policicchio, G., Mesirca, P., Gianino, P., Audenio, E., Paludetto, R., Raimondi, F., Pugliese, A., Valentino, L., Nosari, N., Marchesano, G., Chirico, G., Bell(`u), R., Menchini, M., Poletti, A., Vacchiano, T., Pinto, L., Perri, D., Coppola, R., Perini, R., Vetrella, A., De Luca, G., Lista, G., Cavigioli, F., Bettinelli, A., Massironi, E., Franco, C., Bernardo, L., Poli, S., Palladini, M., Tota, V., Spadavecchia, F., Zuccotti, G. V., Pogliani, L., Bracaglia, G., Mancini, A. L., Zocco, F., Iozzia, G., Auriemma, A., Teani, M., Mangilli, G., Tempra, A. M., Di Terlizi, L., Bottino, R., Salvi, C., Fortunato, V., Musaico, R., Gargantini, G., Carrera, G., Magaldi, R., Taurino, L., D?onofrio, A. M., Buffone, E., Tempera, A., Agosti, M., Garzia, P., Mosca, F., Pugni, L., Tagliabue, P., Colombo, C., Demi, M., Picco, G., Carlucci, A., Zorzi, G., Padula, D., Cardone, M. L., Buonocore, G., Muraca, M. C., Boldrini, A., Ciantelli, M., Lanari, M., Serra, L., Felici, L., Banderalli, G., Brambilla, C., Dall?agnola, A., Viviani, E., Zonca, M. C., Licardi, G., Chiara, A., Ancora, G., Papa, I., Gancia, P., Pomero, G., Deloglu, A., Villani, P., Mussini, P., Canidio, E., Migliavacca, D., Di Fabio, S., Cipollone, I., Biasucci, G., Rubbi, P., Piepoli, M., Guastaferro, N., Infriccioli, F., Bertino, E., Perathoner, C., Parmigiani, S., Suriano, G., Ianniello, C., Biasini, A., Azzalli, M., Timpani, G., Barresi, S., Caoci, G., Ciccotti, R., De Curtis, M., Natale, F., Finocchi, M., Haass, C., Milillo, F., Lucieri, S., Guercio, E., Canepa, S. A., Scozia, G., Antonucci, R., Limongelli, O., Macci(`o), S., Mongelli, F., Colonna, F., Dragovic, D., Calipa, M. T., Cohen, A., Moresco, L., La Spina, R., Ruggeri, R., Luehwink, A., Brattoli, M., Fedi, A., Lacchi, L., Ettore, G., Pappalardo, E., Conoscenti, G., Zeni, B., Spellecchia, D., Favretti, L., Spagna, L., Zaglio, S., Bresciani, D., Bandini, A., Mancini, R., Mustoni, P., Dodero, D., Grimaldi, M., Di Mario, M., Migliorini, P., Kemeny, A., Anastasio, P. S., Riccardi, T., Maggino, T., Cerri, G., Puggina, P., Marconi, A. M., Morgia, S., Bellia, G., D?anna, M. R., Catania, M., Bacchi Modena, A., Franchi, L., Calonaci, N., Schettini, S., Paradiso, R., Saccucci, P., Ioppi, M., Zorzi, M., Stellin, G., Patacchiola, F., Carrata, L., Bassini, D., San Marco, L., Todros, T., Tibadi, C., Liborio, M., Laricchia, R., Tauro, L., Ferrara, F., Nuara, C., Ghiraldi, E., Molinari, F., Comessatti, A., Rocchetti, A., Di Matteo, L., Miconi, V., Calvi, P., Pernigotti, A., Fabozzi, F., Micca, G., Monticone, G., Sarti, M., Da Rin, G., Zoppelletto, M., Modolo, E., Landini, M. P., Furlini, G., Galluppi, E., Pagani, E., Aschbacher, R., Innocenti, P., Bresolin, N., Raggi, M. E., Bonfanti, C., De Francesco, M., Santer, P., Griessmaier, A., De Francesco, D., Pirali, A., Prasciolu, C., Usai, F., Cuzzone, G., Scutell(`a), M., Tramacere, P., Fossati, D., Piaserico, G., Bordignon, G., Sciacca, A., Di Vincenzo, F., Imbriani, A., Melotti, D., Catanoso, G., Rivetti, I., Neri, G., Bruno, R., Bacelle, L., Sartore, P., Giana, G., Sala, E., Giraldi, C., Cavalcanti, P., Perugini, M., Perugini, A., Ginardi, C., Maritano, D., Ferrini, A., Bonettini, A., Avanzini, A., Gasperoni, S., Pieretti, B., Montanari, E., Carillo, C., Rossi, M. R., Laureti, A., Baldoni, M. L., Serra, D., Melioli, G., Bandettini, R., Oneto, F., Colla, R., Storchi Incerti, S., Lanzini, F., Pauri, P., Tili, E., Leone, R. A., Verdastro, G., Megha, M., Luzzaro, F., Conti, A., Busulini, L., Mirri, P., Diodati, R., Vettori, C., Pittalis, S., Anesi, A., Fiore, A., Goglia, L., Vitullo, E., Sinno, A., Platzgummer, S., Spitaler, C., Trabucchi, M. C., Besozzi, M., Cesana, E., Inghilleri, G., Grosso, S., D?angelo, R., Fogato, E., Lavarda, F., Ortisi, G., Clementi, M., Cichero, P., Rumpianesi, F., Venturelli, C., Mortillaro, F., Daffara, S., Catania, M. R., Iula, D., Andreoni, S., Politi, A., Agostinelli, C., Paparella, C., Capozzi, D., Notaris, P., Bistoni, F., Mencacci, A., Valentini, M., Filippetti, A., Confalonieri, M., Novarese, O., Bonini, F., Salamone, D., Camporese, A., De Rosa, R., Casprini, P., Degl?innocenti, R., Giordano, R., All(`u), M. T., Zanella, D., Malandrino, M., Tronci, M., Valmarin, M., Leonetti, G., Falco, S., Meledandri, M., Ballardini, M., Span(`o), A., Cava, M. C., Mascellino, M. T., Schinella, M., Gualdi, P., Casari, E., Scattolo, N., Motta, C., Perfetti, C., Bassano, M., Cera, G., Iafisco, P., Mura, I., Palmieri, A., Migliardi, M., Ferlini, M., Grandi, G., Giardini, F., Albano, F., Latino, M., Ferrero, M. P., Bellizia, L., Russolo, M., Russolo, S., Pesenti, A., Fasano, M. A., Previato, S., Radillo, O., Busetti, M., Ferrari, P., Siderini, V., Puzzolante, L., Scarparo, C., Arzese, A., Cappuccia, N., Lodolo, L., Delledonne, L., Gramoni, A., Maiolo, V., Gheller, A., Spadaro, S., Balzaretti, M., Tzialla, Chryssoula, Berardi, Alberto, Farina, Claudio, Clerici, Pierangelo, Borghesi, Alessandro, Viora, Elsa, Scollo, Paolo, Stronati, Mauro, [.., Lanari, Marcello, Faldella, Giacomo, and ]

Subjects
Male, Pediatrics, Group B, 0302 clinical medicine, Neonate, Pregnancy, Surveys and Questionnaires, Prevalence, Mass Screening, Blood culture, 030212 general & internal medicine, Antibiotic prophylaxis, Survey, GBS, Group B streptococcus, Infection, Newborn infant, Adult, Antibiotic Prophylaxis, Female, Health Surveys, Humans, Infant, Newborn, Italy, Neonatal Screening, Pregnancy Complications, Infectious, Prenatal Care, Primary Prevention, Risk Assessment, Streptococcal Infections, Streptococcus agalactiae, reproductive and urinary physiology, Group B streptococcu, medicine.diagnostic_test, lcsh:RJ1-570, Infectious, Perinatology and Child Health, Pediatrics, Perinatology and Child Health, medicine.medical_specialty, Antibiotic sensitivity, Group B Streptococcal Infection, Prenatal care, 03 medical and health sciences, 030225 pediatrics, medicine, Intensive care medicine, Mass screening, business.industry, Public health, Infant, lcsh:Pediatrics, Newborn, Pregnancy Complications, business
Abstract

Background There are no Italian data regarding the strategies for preventing neonatal group B streptococcal (GBS) infection. We conducted a national survey in order to explore obstetrical, neonatal and microbiological practices for the GBS prevention. Methods Three distinct questionnaires were sent to obstetricians, neonatologists and microbiologists. Questionnaires included data on prenatal GBS screening, maternal risk factors, intrapartum antibiotic prophylaxis, microbiological information concerning specimen processing and GBS antimicrobial susceptibility. Results All respondent obstetrical units used the culture-based screening approach to identify women who should receive intrapartum antibiotic prophylaxis, and more than half of the microbiological laboratories (58%) reported using specimen processing consistent with CDC guidelines. Most neonatal units (89 out of 107, 82%) reported using protocols for preventing GBS early-onset sepsis consistent with CDC guidelines. Conclusions The screening-based strategy is largely prevalent in Italy, and most protocols for preventing GBS early-onset sepsis are consistent with CDC guidelines. However, we found discrepancies in practices among centers that may reflect the lack of Italian guidelines issued by public health organizations.

Published
2017

37. Fully Vapor-Deposited Heterostructured Light-Emitting Diode Based on Organo-Metal Halide Perovskite

Author

D. Simeone, Valentino L. P. Guerra, Marco Mazzeo, Sonia Carallo, Giuseppe Gigli, Silvia Colella, Armando Genco, Salvatore Gambino, Fabrizio Mariano, Andrea Listorti, Genco, Armando, Mariano, Fabrizio, Carallo, Sonia, Guerra, Valentino L. P., Gambino, Salvatore, Simeone, Daniela, Listorti, Andrea, Colella, Silvia, Gigli, Giuseppe, and Mazzeo, Marco

Subjects
Materials science, business.industry, Halide, 02 engineering and technology, Vapour deposition, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, 01 natural sciences, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, law.invention, Metal, law, visual_art, visual_art.visual_art_medium, Optoelectronics, 0210 nano-technology, business, Perovskite (structure), Light-emitting diode
Published
2016

38. Loss of coral reef growth capacity to track future increases in sea level

Author

Perry, C, Alvarez-Filip, L, Graham, Nicholas Anthony James, Mumby, PJ, Wilson, SK, Kench, PS, Manzello, DP, Morgan, KM, Slangen, ABA, Thomson, DP, Janchowski-Hartley, F, Smithers, SG, Steneck, RS, Carlton, R, Edinger, EE, Enochs, IC, Estrada-Saldivar, N, Haywood, MDE, Kolodziej, G, Murphy, GN, Perez-Cervantes, E, Suchley, A, Valentino, L, Boenish, R, Wilson, M, Macdonald, C, Perry, C, Alvarez-Filip, L, Graham, Nicholas Anthony James, Mumby, PJ, Wilson, SK, Kench, PS, Manzello, DP, Morgan, KM, Slangen, ABA, Thomson, DP, Janchowski-Hartley, F, Smithers, SG, Steneck, RS, Carlton, R, Edinger, EE, Enochs, IC, Estrada-Saldivar, N, Haywood, MDE, Kolodziej, G, Murphy, GN, Perez-Cervantes, E, Suchley, A, Valentino, L, Boenish, R, Wilson, M, and Macdonald, C

Abstract

Sea-level rise (SLR) is predicted to elevate water depths above coral reefs and to increase coastal wave exposure as ecological degradation limits vertical reef growth, but projections lack data on interactions between local rates of reef growth and sea level rise. Here we calculate the vertical growth potential of more than 200 tropical western Atlantic and Indian Ocean reefs, and compare these against recent and projected rates of SLR under different Representative Concentration Pathway (RCP) scenarios. Although many reefs retain accretion rates close to recent SLR trends, few will have the capacity to track SLR projections under RCP4.5 scenarios without sustained ecological recovery, and under RCP8.5 scenarios most reefs are predicted to experience mean water depth increases of more than 0.5 m by 2100. Coral cover strongly predicts reef capacity to track SLR, but threshold cover levels that will be necessary to prevent submergence are well above those observed on most reefs. Urgent action is thus needed to mitigate climate, sea-level and future ecological changes in order to limit the magnitude of future reef submergence.

Published
2018

39. Loss of coral reef growth capacity to track future increases in sea level

Author

Perry, C.T., Alvarez-Filip, L., Graham, N.A.J., Mumby, P.J., Wilson, S.K., Kench, P.S., Manzello, D.P., Morgan, K.M., Slangen, A.B.A., Thomson, D.P., Januchowski-Hartley, F., Smithers, S.G., Steneck, R.S., Carlton, R., Edinger, E., Enochs, I.C., Estrada-Saldívar, N., Haywood, M.D.E., Kolodziej, G., Murphy, G.N., Pérez-Cervantes, E., Suchley, A., Valentino, L., Boenish, R., Wilson, M., Macdonald, C., Perry, C.T., Alvarez-Filip, L., Graham, N.A.J., Mumby, P.J., Wilson, S.K., Kench, P.S., Manzello, D.P., Morgan, K.M., Slangen, A.B.A., Thomson, D.P., Januchowski-Hartley, F., Smithers, S.G., Steneck, R.S., Carlton, R., Edinger, E., Enochs, I.C., Estrada-Saldívar, N., Haywood, M.D.E., Kolodziej, G., Murphy, G.N., Pérez-Cervantes, E., Suchley, A., Valentino, L., Boenish, R., Wilson, M., and Macdonald, C.

Abstract

Sea-level rise (SLR) is predicted to elevate water depths above coral reefs and to increase coastal wave exposure asecological degradation limits vertical reef growth, but projections lack data on interactions between local rates of reefgrowth and sea level rise. Here we calculate the vertical growth potential of more than 200 tropical western Atlanticand Indian Ocean reefs, and compare these against recent and projected rates of SLR under different RepresentativeConcentration Pathway (RCP) scenarios. Although many reefs retain accretion rates close to recent SLR trends, few willhave the capacity to track SLR projections under RCP4.5 scenarios without sustained ecological recovery, and underRCP8.5 scenarios most reefs are predicted to experience mean water depth increases of more than 0.5 m by 2100. Coralcover strongly predicts reef capacity to track SLR, but threshold cover levels that will be necessary to prevent submergenceare well above those observed on most reefs. Urgent action is thus needed to mitigate climate, sea-level and futureecological changes in order to limit the magnitude of future reef submergence.

Published
2018

41. Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis

Author

Poli Van Creveldkliniek Medisch, Circulatory Health, Valentino, L. A., Pipe, S. W., Collins, P. W., Blanchette, V. S., Berntorp, E., Fischer, K., Ewenstein, B. M., Oh, M., Spotts, G., Poli Van Creveldkliniek Medisch, Circulatory Health, Valentino, L. A., Pipe, S. W., Collins, P. W., Blanchette, V. S., Berntorp, E., Fischer, K., Ewenstein, B. M., Oh, M., and Spotts, G.

Published
2016

42. Changes in physicochemical and transport properties of a reverse osmosis membrane exposed to chloraminated seawater

Author

Valentino, L., Renkens, T., Maugin, T., Croué, Jean-Philippe, Mariñas, B., Valentino, L., Renkens, T., Maugin, T., Croué, Jean-Philippe, and Mariñas, B.

Abstract

This study contributed to improving our understanding of how disinfectants, applied to control biofouling of reverse osmosis (RO) membranes, result in membrane performance degradation. We investigated changes in physicochemical properties and permeation performance of a RO membrane with fully aromatic polyamide (PA) active layer. Membrane samples were exposed to varying concentrations of monochloramine, bromide, and iodide in both synthetic and natural seawater. Elemental analysis of the membrane active layer by Rutherford backscattering spectrometry (RBS) revealed the incorporation of bromine and iodine into the polyamide. The kinetics of polyamide bromination were first order with respect to the concentration of the secondary oxidizing agent Br2 for the conditions investigated. Halogenated membranes were characterized after treatment with a reducing agent and heavy ion probes to reveal the occurrence of irreversible ring halogenation and an increase in carboxylic groups, the latter produced as a result of amide bond cleavage. Finally, permeation experiments revealed increases in both water permeability and salt passage as a result of oxidative damage.

Published
2015

45. Valutazioni igienico-sanitarie delle acque in tre invasi artificiali della provincia di Palermo destinate al consumo umano

Author

Gullotti, A., Valentino, L., Oliveri, R., Casuccio, A., Mantia, L., Marinaro, L., Pedalino, B., Purpari, G., Tramuto, F., Torregrossa, M., Gullotti, A., Valentino, L., Oliveri, R., Casuccio, A., Mantia, L., Marinaro, L., Pedalino, B., Purpari, G., Tramuto, F., and Torregrossa, M.

Subjects
reservoirs, drinking waters sanitary conditions
Abstract

We report the physico-chemical and bacteriological characteristics of three Sicilian reservoirs. The aim of this study was the evaluation of the reservoirs' sanitary conditions, given tha the water is also used for human consumption. 114 samples (4 locations at each lake) were collected in the period from July 1995 to June 1996. We analysed temperature, pH, oxygen saturation, colour and parameters of water mineralization and pollution of natural or human origin.Pathogenic bacteria (Salòmonellae) and opportunistic patjogens such as Pseudomonas aeruginosa and Aeromonas spp. were also investigated. At present, results are not showing particular levels of pollution, and it seems there is no risk for these lacustrine environments. Authors point out a higher exposure of Poma reservoir to polluting elements and a certain deterioration of its water quality compared with previous investigations. Water samples from each of the reservoirs are within the limits of Italian legislation regarding surface waters intended for human use.

Published
1998

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