1. Protective efficacy of Capsicum frutescens fruits in pancreatic, hepatic and renal cell injury and their attenuation of oxidative stress in diabetic Wistar rats
- Author
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M. R. Maya, V. Ananthi, A. Arun, P. Kumar, M. Govarthanan, K. Rameshkumar, V. Veeramanikandan, and P. Balaji
- Subjects
capsicum frutescens ,enzymatic antioxidant system ,non-enzymatic antioxidants ,hypoglycemic activity ,streptozotocin (stz) induced diabetes ,Science (General) ,Q1-390 - Abstract
According to our insight, it is the first investigation based on a literature review to establish the oxidative stress defense and hypoglycemic effects of Capsicum frutescens fruits. The anti-hyperglycemic effect of acetone extract of the fruits of C. frutescens (CFA) was imposed at 250mg/kg and 500mg/kg for 21 days in diabetic-induced Wistar rats. The rats were divided into five groups as control, diabetic, diabetic receiving glibenclamide, and two diabetic receiving CFA-treatment groups. Beginning on the 4th day and up to the 21st day of therapy, CFA at 250mg/kg and 500mg/kg demonstrated a substantial decrease in Blood Glucose Levels (BGL). CFA at 500mg/kg led to a considerable decrease in Low-Density Lipoprotein (LDL) cholesterol and a substantial increase in High-Density Lipoprotein (HDL) cholesterol, showing that CFA possesses anti-diabetic properties. Histopathological examinations reveal hepatic, pancreatic, and renal regularization. As a result, the current study clearly demonstrated more important antidiabetic activity of CFA extracts.
- Published
- 2021
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