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Aim. To evaluate the efficacy of cascade plasma filtration (CPF) for the correction of lipid profile and biochemical markers (sFlt-1, PIGF, sFlt-1/PIGF) in pregnant women with early preeclampsia. Materials and Methods. A prospective controlled study of 23 CPF procedures was conducted in 11 pregnant women with early preeclampsia at gestational ages 22 to 31 weeks. The evolution of clinical manifestations of preeclampsia (BP, urine output, and proteinuria), laboratory biochemical parameters (protein/creatinine ratio, lipid profile), blood coagulation tests, and thromboelastometry (ROTEM) were assessed. In addition, the effect of CPF on the level of preeclampsia markers (sFlt-1, PIGF, sFlt-1/PIGF-ratio) as predictors of endothelial aggression was analyzed. The efficacy of extracorporeal therapy was evaluated based on the duration of pregnancy prolongation. Results. The use of CPF as an adjunct for the treatment of early preeclampsia had a positive effect on the lipid profile by reducing cholesterol and LDL, which helped to decrease atherogenic aggression on the vascular endothelium. In addition, the extracorporeal therapy promoted reduction of the anti-angiogenic effect of sFlt-1, which was confirmed by a significant decrease in the sFlt-1/PIGF ratio from 515 [347; 750] to 378 [285; 557] (P = 0.013). The period of prolongation of pregnancy was longer in the main group (with CPF) and was 19 [5; 26] days, whereas in the comparison group (without CPF) it was 3 [1; 4] days (P < 0.001). All newborns were discharged from the hospital in a stable condition. The paper is supplemented with a clinical observation of the effective use of CPF in early preeclampsia. Conclusion. The use of cascade plasma filtration in the treatment of early preeclampsia to prolong pregnancy could be a promising approach.

We consider a high-Q microresonator with χ^{(2)} nonlinearity under conditions when the coupling rate between the sidebands around the pump and its second harmonic exceeds the damping rates, implying the strong coupling regime (SC). Using the dressed-resonator approach we demonstrate that this regime leads to the dominance of the Hermitian part of the operator, driving the sideband dynamics over its non-Hermitian part responsible for the parametric gain. This has allowed us to introduce and apply the cross-area concept of the polariton quasiparticles and their effective masses in the context of χ^{(2)} ring microresonators. We further use polaritons to predict the modified spectral response of the resonator to the weak probe field, and to reveal the splitting of the bare-resonator resonances, avoided crossings, and Rabi dynamics. Polariton basis also allows the deriving of a discrete sequence of the parametric thresholds for generation of sidebands of different orders.

The article deals with the comparative and theoretical analysis of the major approaches towards researching the phenomenon of self-realization of the personality.