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2. Direct conversion of osteosarcoma to adipocytes by targeting TNIK

Author

Hirozane, Toru, primary, Masuda, Mari, additional, Sugano, Teppei, additional, Sekita, Tetsuya, additional, Goto, Naoko, additional, Aoyama, Toru, additional, Sakagami, Takato, additional, Uno, Yuko, additional, Moriyama, Hideki, additional, Sawa, Masaaki, additional, Asano, Naofumi, additional, Nakamura, Masaya, additional, Matsumoto, Morio, additional, Nakayama, Robert, additional, Kondo, Tadashi, additional, Kawai, Akira, additional, Kobayashi, Eisuke, additional, and Yamada, Tesshi, additional

Published
2021
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3. Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846

Author

Sugano, Teppei, primary, Masuda, Mari, additional, Takeshita, Fumitaka, additional, Motoi, Noriko, additional, Hirozane, Toru, additional, Goto, Naoko, additional, Kashimoto, Shigeki, additional, Uno, Yuko, additional, Moriyama, Hideki, additional, Sawa, Masaaki, additional, Nagakawa, Yuichi, additional, Tsuchida, Akihiko, additional, Seike, Masahiro, additional, Gemma, Akihiko, additional, and Yamada, Tesshi, additional

Published
2020
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4. Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma

Author

Sekita, Tetsuya, primary, Yamada, Tesshi, additional, Kobayashi, Eisuke, additional, Yoshida, Akihiko, additional, Hirozane, Toru, additional, Kawai, Akira, additional, Uno, Yuko, additional, Moriyama, Hideki, additional, Sawa, Masaaki, additional, Nagakawa, Yuichi, additional, Tsuchida, Akihiko, additional, Matsumoto, Morio, additional, Nakamura, Masaya, additional, Nakayama, Robert, additional, and Masuda, Mari, additional

Published
2020
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6. Detection of betacyanin in red-tube spinach (Spinacia oleracea) and its biofortification by strategic hydroponics

Author

10722184, 90183201, Watanabe, Sho, Ohtani, Yuta, Aoki, Wataru, Uno, Yuko, Sukekiyo, Yasunori, Kubokawa, Seiichi, Ueda, Mitsuyoshi, 10722184, 90183201, Watanabe, Sho, Ohtani, Yuta, Aoki, Wataru, Uno, Yuko, Sukekiyo, Yasunori, Kubokawa, Seiichi, and Ueda, Mitsuyoshi

Abstract

Betacyanins have been reported as water-soluble, nitrogenous pigments found in the order Caryophyllales, and they are known for powerful natural antioxidant. The biofortification of secondary metabolites such as anthocyanins and betacyanins has recently been performed in food crops by metabolic engineering through genetic modification. However, the distribution of genetically modified foods is strictly regulated. Therefore, we aimed to develop a new method for biofortifying natural antioxidants, betacyanins, without genetic modification. We first detected the presence of betacyanins in red-tube spinach (Spinacia oleracea) through ultraviolet-visible spectroscopy and mass spectrometry. We then hydroponically cultivated plants in the presence of three candidate compounds for betacyanin biofortification: dopamine, Ca2+, and sucrose. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) and antioxidant activity analyses showed that sucrose was most successful in biofortifying betacyanins, and reverse transcription polymerase chain reaction (RT-PCR) indicated that several genes involved in betacyanin biosynthesis were induced by sucrose. Therefore, strategic hydroponics represents a new approach for cultivating betacyanin-enriched vegetables.

Published
2018

8. Expression, Functional Characterization, and Preliminary Crystallization of the Cochaperone Prefoldin from the Thermophilic Fungus Chaetomium thermophilum

Author

Morita, Kento, primary, Yamamoto, Yohei, additional, Hori, Ayaka, additional, Obata, Tomohiro, additional, Uno, Yuko, additional, Shinohara, Kyosuke, additional, Noguchi, Keiichi, additional, Noi, Kentaro, additional, Ogura, Teru, additional, Ishii, Kentaro, additional, Kato, Koichi, additional, Kikumoto, Mahito, additional, Arranz, Rocio, additional, Valpuesta, Jose, additional, and Yohda, Masafumi, additional

Published
2018
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11. TNIK inhibition abrogates colorectal cancer stemness

Author

Masuda, Mari, primary, Uno, Yuko, additional, Ohbayashi, Naomi, additional, Ohata, Hirokazu, additional, Mimata, Ayako, additional, Kukimoto-Niino, Mutsuko, additional, Moriyama, Hideki, additional, Kashimoto, Shigeki, additional, Inoue, Tomoko, additional, Goto, Naoko, additional, Okamoto, Koji, additional, Shirouzu, Mikako, additional, Sawa, Masaaki, additional, and Yamada, Tesshi, additional

Published
2016
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