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10,065 results on '"University of Southampton [Southampton]"'

1. Effect of Oestrogen on Musculoskeletal Outcomes (E2)

Author: University of East Anglia, Norwich, United Kingdom, Osteolabs, Kiel, Germany, University of Salford, Salford, United Kingdom, University of Southampton, Southampton, United Kingdom, and Dr. Thomas O'Leary, Higher Scientific Officer
Published: 2023

2. HERAFitter

Author: Alekhin, S.Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738, Zeuthen, Germany, Behnke, O.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Belov, P.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Borroni, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Botje, M.(Nikhef, Science Park, Amsterdam, The Netherlands), Britzger, D.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Camarda, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Cooper-Sarkar, A. M.(Department of Physics, University of Oxford, Oxford, UK), Daum, K.(Fachbereich C, Universität Wuppertal, Wuppertal, Germany), Diaconu, C.(Aix Marseille Universite, CNRS/IN2P3, CPPM UMR 7346, 13288, Marseille, France), Feltesse, J.(CEA, DSM/Irfu, CE-Saclay, Gif-sur-Yvette, France), Gizhko, A.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Glazov, A.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Guffanti, A.(Niels Bohr International Academy and Discovery Center, Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100, Copenhagen, Denmark), Guzzi, M.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Hautmann, F.(School of Physics and Astronomy, University of Southampton, Southampton, UK), Jung, A.(FERMILAB, 60510, Batavia, IL, USA), Jung, H.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Kolesnikov, V.(Joint Institute for Nuclear Research (JINR), Joliot-Curie 6, 141980, Dubna, Moscow Region, Russia), Kowalski, H.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Kuprash, O.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Kusina, A.(Southern Methodist University, Dallas, TX, USA), Levonian, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Lipka, K.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Lobodzinski, B.(Max Planck Institut für Physik, Werner Heisenberg Institut, Föhringer Ring 6, München, Germany), Lohwasser, K.(Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738, Zeuthen, Germany), Luszczak, A.(T. Kosciuszko University of Technology, Kraków, Poland), Malaescu, B.(Laboratoire de Physique Nucléaire et de Hautes Energies, UPMC and Université, Paris-Diderot and CNRS/IN2P3, Paris, France), McNulty, R.(University College Dublin, Dublin 4, Ireland), Myronenko, V.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Naumann-Emme, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Nowak, K.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Olness, F.(Southern Methodist University, Dallas, TX, USA), Perez, E.(CERN, European Organization for Nuclear Research, Geneva, Switzerland), Pirumov, H.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Plačakytė, R.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Rabbertz, K.(Institut für Experimentelle Kernphysik, Karlsruhe, Germany), Radescu, V.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Sadykov, R.(Joint Institute for Nuclear Research (JINR), Joliot-Curie 6, 141980, Dubna, Moscow Region, Russia), Salam, G. P.(CERN, PH-TH, 1211, Geneva 23, Switzerland), Sapronov, A.(Joint Institute for Nuclear Research (JINR), Joliot-Curie 6, 141980, Dubna, Moscow Region, Russia), Schöning, A.(Physikalisches Institut, Universität Heidelberg, Heidelberg, Germany), Schörner-Sadenius, T.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Shushkevich, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Slominski, W.(Institute of Physics, Jagiellonian University, Reymonta 4, 30-059, Kraków, Poland), Spiesberger, H.(PRISMA Cluster of Excellence, Institut für Physik (WA THEP), Johannes-Gutenberg-Universität, 55099, Mainz, Germany), Starovoitov, P.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Sutton, M.(Department of Physics and Astronomy, University of Sussex, Sussex House, BN1 9RH, Brighton, UK), Tomaszewska, J.(Faculty of Physics, Warsaw University of Technology, Koszykowa 75, 00-662, Warsaw, Poland), Turkot, O.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Vargas, A.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Watt, G.(Institute for Particle Physics Phenomenology, Durham University, DH1 3LE, Durham, UK), and Wichmann, K.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany)
Subjects: Physics and Astronomy (miscellaneous), Physics, High Energy Physics::Experiment, Nuclear Experiment, Engineering (miscellaneous), QC
Abstract: HERAFitter is an open-source package that provides a framework for the determination of the parton distribution functions (PDFs) of the proton and for many different kinds of analyses in Quantum Chromodynamics (QCD). It encodes results from a wide range of experimental measurements in lepton-proton deep inelastic scattering and proton-proton (proton-antiproton) collisions at hadron colliders. These are complemented with a variety of theoretical options for calculating PDF-dependent cross section predictions corresponding to the measurements. The framework covers a large number of the existing methods and schemes used for PDF determination. The data and theoretical predictions are brought together through numerous methodological options for carrying out PDF fits and plotting tools to help to visualise the results. While primarily based on the approach of collinear factorisation, HERAFitter also provides facilities for fits of dipole models and transverse-momentum dependent PDFs. The package can be used to study the impact of new precise measurements from hadron colliders. This paper describes the general structure of HERAFitter and its wide choice of options.
Published: 2015

3. EXACT ELASTIC STABILITY ANALYSIS BASED ON DYNAMIC STIFFNESS METHOD

Author: Iakovliev, Andrii; University of Southampton, Southampton, United Kingdom and Iakovliev, Andrii; University of Southampton, Southampton, United Kingdom
Abstract: The article is dedicated to the discussion on the exact dynamic stiffness matrix method applied to the problems of elastic stability of engineering structures. The detailed formulation of the member dynamic stiffness matrix for beams is presented along with the general guidelines on automatisation of the assembly of member dynamic stiffness matrices into the global matrix that corresponds to the whole structure. The advantage of the dynamic stiffness matrix in case of parametric studies is explained. The problem of computing the eigenvalues of transcendental matrix is addressed. The straightforward approach as well as a powerful Witrick-Williams algorithm are discussed in details. The general guidelines on programming the DS matrix method are given as well., Статья посвящена обсуждению применения точного метода динамической матрицы жесткости к проблемам упругой устойчивости инженерных конструкций. В статье представлен вывод динамической матрицы жесткости для структурных балочных компонентов с последующим руководством к автоматизации сборки глобальной динамической матрицы жесткости для всей конструкции из матриц для каждого компонента. Также обсуждаются преимущества метода динамической матрицы жесткости в случае параметрических расчетов. Проанализирована проблема расчета собственных значений трансцендентной матрицы жесткости. В деталях анализируются как метод прямого расчета собственных значений, так и мощный алгоритм Виттрика-Вильямса. В статье также приводится общее руководство к программированию метода динамической матрицы жесткости.
Published: 2016

4. Pseudomonas aeruginosa: A model for biofilm formation

Author: Rhem, B., McDougald, Diane, Centre for Marine Biofouling & Bioinnovation, UNSW, Klebensberger, Janosch, Centre for Marine Biofouling & Bioinnovation, UNSW, Tolker-Nielsen, Tim, Centre for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark, Webb, Jeremy S., School of Biological Sciences, University of Southampton, Southampton, UK, Conibear, Tim, School of Biological Sciences, University of Southampton, Southampton, UK, Rice, Scott A., Centre for Marine Biofouling & Bioinnovation, UNSW, Kirov, Sylvia M., School of Medicine (Pathology), University of Tasmania, Hobart, Australia, Matz, Carsten, GBF - National Research Centre for Biotechnology, Center for Biomedical Microbiology, Kjelleberg, Staffan, Centre for Marine Biofouling & Bioinnovation, UNSW, Rhem, B., McDougald, Diane, Centre for Marine Biofouling & Bioinnovation, UNSW, Klebensberger, Janosch, Centre for Marine Biofouling & Bioinnovation, UNSW, Tolker-Nielsen, Tim, Centre for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark, Webb, Jeremy S., School of Biological Sciences, University of Southampton, Southampton, UK, Conibear, Tim, School of Biological Sciences, University of Southampton, Southampton, UK, Rice, Scott A., Centre for Marine Biofouling & Bioinnovation, UNSW, Kirov, Sylvia M., School of Medicine (Pathology), University of Tasmania, Hobart, Australia, Matz, Carsten, GBF - National Research Centre for Biotechnology, Center for Biomedical Microbiology, and Kjelleberg, Staffan, Centre for Marine Biofouling & Bioinnovation, UNSW
Abstract: Much of the fundamental understanding of microbial physiology is based onlaboratory studies of freely suspended cells. While these studies have been essentialfor our foundational understanding of the genetics, physiology and behavior ofmicrobes, it is now recognized that a majority of bacterial cells in nature exist inbiofilms [1] associated with surfaces or as floating cell aggregates. In fact, it hasrecently been proposed that microbial communities originally developed on surfaces,including the first bacterial and archael cells, and that the planktonic cell phenotypeevolved as a dispersal mechanism [2]. Hallmarks of cells residing in biofilmcommunities are increased metabolic efficiency [3] as well as increased resistanceto environmental stresses such as desiccation, ultraviolet radiation and oxidativestress [4–6]. This correlation has dramatic consequences as residing in aggregateshas been shown to confer increased resistance of bacterial cells also to biocides suchas antibiotics, disinfectants and detergents [7–9]. In addition, once established, thesebiofilms are able to resist invasion by other organisms and predation by protozoans innature or host immune cells in the human body [5,6,10]. This is especially problematicas it is also recognized that the majority of bacterial infections involve biofilms[11]. The recent explosion of research in the field of biofilm biology has led to anenhanced appreciation for the multicellular aspects of microbiology and has resultedin the general acceptance of a model of the biofilm mode of life.Pseudomonas aeruginosa has become a model organism for the study of biofilmsdue to its metabolic versatility and variability in its response to environmental signals,which promotes successful colonization of different habitats and growth undervarying environmental conditions [12,13]. This ability is likely a reflection of its largegenome, allowing for metabolic plasticity and quick responses to varying stimuli.P. aeruginosa is also a hum
Published: 2008

5. The t(1;9)(p34;q34) fusing ABL1 with SFPQ, a pre-mRNA processing gene, is recurrent in acute lymphoblastic leukemias.

Author: UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Institut Gustave Roussy, Villejuif, France - Laboratoire de Cytogénétique, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg - Service d’Hémato-Cancérologie, Institut Gustave Roussy, Villejuif, France - Service d’Hématologie, University of Southampton, Southampton, United Kingdom - Wessex Regional Genetics Laboratory, Salisbury District Hospital and Human Genetics Division, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Centre de génétique médicale UCL, Duhoux, François, Auger, Nathalie, De Wilde, Sigrid, Wittnebel, Sebastian, Ameye, Geneviève, Bahloula, Khadija, Van den Berg, Catherine, Libouton, Jeanne-Marie, Saussoy, Pascale, Grand, Francis H, Demoulin, Jean-Baptiste, Poirel, Hélène, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Institut Gustave Roussy, Villejuif, France - Laboratoire de Cytogénétique, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg - Service d’Hémato-Cancérologie, Institut Gustave Roussy, Villejuif, France - Service d’Hématologie, University of Southampton, Southampton, United Kingdom - Wessex Regional Genetics Laboratory, Salisbury District Hospital and Human Genetics Division, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Centre de génétique médicale UCL, Duhoux, François, Auger, Nathalie, De Wilde, Sigrid, Wittnebel, Sebastian, Ameye, Geneviève, Bahloula, Khadija, Van den Berg, Catherine, Libouton, Jeanne-Marie, Saussoy, Pascale, Grand, Francis H, Demoulin, Jean-Baptiste, and Poirel, Hélène
Published: 2011

6. Differential suppression of tumor-specific CD8+ T Cells by regulatory T cells

Author: University of Southampton, Southampton, UK - Cancer Sciences Division, School of Medicine, Hannover Medical School, Hannover, Germany - Department of Gastroenterology, Hepatology, and Endocrinology, UCL - SSS/DDUV - Institut de Duve, James, Edward, Yeh, Alex, King, Cathy, Korangy, Firouzeh, Bailey, Ian, Boulanger, Denise S., Van den Eynde, Benoît, Murray, Nicholas, Elliott, Tim J., University of Southampton, Southampton, UK - Cancer Sciences Division, School of Medicine, Hannover Medical School, Hannover, Germany - Department of Gastroenterology, Hepatology, and Endocrinology, UCL - SSS/DDUV - Institut de Duve, James, Edward, Yeh, Alex, King, Cathy, Korangy, Firouzeh, Bailey, Ian, Boulanger, Denise S., Van den Eynde, Benoît, Murray, Nicholas, and Elliott, Tim J.
Abstract: In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.
Published: 2010

7. Supersymmetry parameter analysis: SPA convention and project

Author: MCTP, University of Michigan, Ann Arbor, MI, USA, Department of Modern Physics, University of Science and Technology of China, Hefei, China, William I. Fine Theoretical Physics Institute, University of Minnesota, Minneapolis, MN, USA, Laboratoire de Physique des Particules, Annecy-le-Vieux, France, Laboratoire de Physique Subatomique et de Cosmologie, Universit?? Grenoble I, Grenoble, France, Department of Physics, Tohoku University, Sendai, Japan, IPPP, University of Durham, Durham, UK, Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA, PH Department, CERN, Geneva, Switzerland, Department of Physics, Texas A&M University, College Station, TX, USA, Institut f??r Hochenergiephysik, ??sterreichische Akademie der Wissenschaften, Wien, Austria, Institut f??r Experimentalphysik, Universit??t Hamburg, Hamburg, Germany, Max-Planck-Institut f??r Physik, M??nchen, Germany, Department of Mathematical Sciences, University of Liverpool, Liverpool, UK, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany, Institute of Theoretical Physics, Warsaw University, Warsaw, Poland, Laboratoire de Physique Theorique, Annecy-le-Vieux, France, Physikalisches Institut, Universit??t Freiburg, Freiburg, Germany, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China, Department of Physics and Astronomy, University of Rochester, Rochester, NY, USA, Lawrence Berkeley National Laboratory, Berkeley, CA, USA, School of Physics and Astronomy, University of Southampton, Southampton, UK, Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA, LPTA, Universit?? Montpellier II, CNRS-IN2P3, Montpellier, France, High Energy Physics Division, Argonne National Laboratory, Argonne, IL, USA, Department of Physics and Astronomy, University of Sheffield, Sheffield, UK, Harish-Chandra Research Institute, Allahabad, India, University of Colorado, Boulder, CO, USA, IPN Universit?? Lyon, IN2P3-CNRS, Lyon, France, Theory Division, KEK, Tsukuba, Japan, Center for High Energy Physics and Institute of Modern Physics, Tsinghua University, Beijing, China, Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA, USA, Fermi National Accelerator Laboratory, Batavia, IL, USA, Departamento de Fisica and CFTP, Instituto Superior Tecnico, Lisbon, Portugal, Department of Physics and Astronomy, University of Glasgow, Glasgow, UK, Deutsches Elektronen-Synchrotron DESY, Zeuthen, Germany, Department of Physics, National Taiwan University, Taipei, Taiwan, Paul Scherrer Institut, Villigen, Switzerland, Institut f??r Theoretische Physik, Universit??t Z??rich, Z??rich, Switzerland, LAL, Universit?? de Paris-Sud, IN2P3-CNRS, Orsay, France, Stanford Linear Accelerator Center, Stanford, CA, USA; University of Delhi, Delhi, India, Institut f??r Theoretische Physik und Astrophysik, Universit??t W??rzburg, W??rzburg, Germany, Instituto de F??sica, UNAM, M??xico, Mexico, School of Physics, Seoul National University, Seoul, Korea, Stanford Linear Accelerator Center, Stanford, CA, USA; PH Department, CERN, Geneva, Switzerland, Tata Institute of Fundamental Research, Mumbai, India, Department of Physics, University of Wisconsin, Madison, WI, USA, Instituto de F??sica Corpuscular, CSIC, Val??ncia, Spain, Department of Physics, Florida State University, Tallahassee, FL, USA, Department of Theoretical Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece, Centre for High Energy Physics, Indian Institute of Science, Bangalore, India, Institut f??r Theoretische Physik, RWTH Aachen, Aachen, Germany, Facultat de F??sica, Universitat de Barcelona, Barcelona, Spain, Department of Physics, Yonsei University, Seoul, Korea, Physikalisches Institut der Universit??t Bonn, Bonn, Germany, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA, Department of Physics, Chung-Ang University, Seoul, Korea, Department of Physics, Carleton University, Ottawa, ON, Canada, Institut f??r Theoretische Physik, Universit??t Wien, Wien, Austria, Institut f??r Theoretische Physik, Universit??t Z??rich, Z??rich, Switzerland; Instituto de F??sica Corpuscular, CSIC, Val??ncia, Spain, Department of Physics, University of Florida, Gainesville, FL, USA, Royal Holloway University of London, Egham, Surrey, UK, Department of Physics, Chonbuk National University, Chonju, Korea, Skobeltsyn Institute of Nuclear Physics, MSU, Moscow, Russia, Institute of Theoretical Physics, University of Tokushima, Tokushima, Japan, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany; I. Physikalisches Institut der RWTH Aachen, Aachen, Germany, High Energy Physics, Uppsala University, Uppsala, Sweden, ICEPP, University of Tokyo, Tokyo, Japan, YITP, Kyoto Universty, Kyoto, Japan, ITP, School of Physics, Peking University, Beijing, China, Department of Physics, University of California, Davis, CA, USA, Department of Physics, Tokyo Gakugei University, Tokyo, Japan, DAMTP, University of Cambridge, Cambridge, UK, Physics Department, Universidad Catolica de Chile, Santiago, Chile, Stanford Linear Accelerator Center, Stanford, CA, USA, INFN, Sezione di Pavia, Pavia, Italy, High Energy Physics Division, Argonne National Laboratory, Argonne, IL, USA; Enrico Fermi Institute, University of Chicago, Chicago, IL, USA, Ann Arbor, Allanach, B. C., King, S. F., Blair, G. A., Kraml, S., Kim, C. S., Bagger, J. A., Barnett, M., Ellis, J., Hou, Wei-Shu, Roy, P., Yamada, Y., Xing, Z. -Z., Hurth, T., Jiang, Y., Zerwas, P. M., Belyaev, A., Reuter, J., Langacker, Paul, Valle, J. W. F., M??hlleitner, M. M., Spira, M., Nojiri, M. M., Majerotto, W., Moortgat-Pick, G., Moretti, S., Hesselbach, S., He, H. -J., Haber, H. E., Hagiwara, K., Boos, E., Carena, M., Aguilar-Saavedra, J. A., Miller, D. J., Nowak, H., Nomura, D., Okada, N., Lafaye, R., Erler, J., Wienemann, P., Polesello, G., Jones, D. R. T., Fritzsche, T., Zerwas, D., B??langer, G., Bartl, A., Richardson, P., Rolbiecki, K., Schleper, P., Kilian, W., Rzehak, H., Kang, S. K., Yang, J. M., Bechtle, P., Freitas, A., Kane, Gordon L., Fraas, H., Kalinowski, J., Kamon, T., Jack, I., Eberl, H., Dutta, B., Dutta, S., Barger, V., Wagner, C. E. M., Ma, W. -G., Rainwater, D., Berger, E. L., Desch, K., Gounaris, G. J., Godbole, R. M., Guasch, J., Olive, K. A., Kittel, O., Klasen, M., Kr??mer, M., Logan, H. E., Zhang, R. -Y., Skands, P., Weiglein, G., Slavich, P., Zhang, X., Deppisch, F., Ali, Aejaz., Choi, S. Y., Han, T., Haba, N., Roeck, Albert De, Matchev, Konstantin T., Han, L., Heinemeyer, S., Martyn, H. -U., Moultaka, G., Mondragon, M., Sphicas, P., Mori, T., Mukhopadhyaya, B., Muanza, S., St??ckinger, D., Nauenberg, U., Tait, T., Tovey, D. R., Siyeon, K., Hidaka, K., Gunion, J., R??ckl, R., Weber, Ch., Hirsch, M., Hinchliffe, I., Djouadi, A., Peskin, M., Plehn, T., Arnowitt, R., Diaz, M. A., Baer, H. A., Porod, W., Balazs, C., Quevedo, F., Hohenwarter-Sodek, K., Kernreiter, T., Zhu, S. -H., Battaglia, Marco, ??ller, W., Hollik, W., Kovarik, K., Kneur, J. -L., MCTP, University of Michigan, Ann Arbor, MI, USA, Department of Modern Physics, University of Science and Technology of China, Hefei, China, William I. Fine Theoretical Physics Institute, University of Minnesota, Minneapolis, MN, USA, Laboratoire de Physique des Particules, Annecy-le-Vieux, France, Laboratoire de Physique Subatomique et de Cosmologie, Universit?? Grenoble I, Grenoble, France, Department of Physics, Tohoku University, Sendai, Japan, IPPP, University of Durham, Durham, UK, Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA, PH Department, CERN, Geneva, Switzerland, Department of Physics, Texas A&M University, College Station, TX, USA, Institut f??r Hochenergiephysik, ??sterreichische Akademie der Wissenschaften, Wien, Austria, Institut f??r Experimentalphysik, Universit??t Hamburg, Hamburg, Germany, Max-Planck-Institut f??r Physik, M??nchen, Germany, Department of Mathematical Sciences, University of Liverpool, Liverpool, UK, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany, Institute of Theoretical Physics, Warsaw University, Warsaw, Poland, Laboratoire de Physique Theorique, Annecy-le-Vieux, France, Physikalisches Institut, Universit??t Freiburg, Freiburg, Germany, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China, Department of Physics and Astronomy, University of Rochester, Rochester, NY, USA, Lawrence Berkeley National Laboratory, Berkeley, CA, USA, School of Physics and Astronomy, University of Southampton, Southampton, UK, Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA, LPTA, Universit?? Montpellier II, CNRS-IN2P3, Montpellier, France, High Energy Physics Division, Argonne National Laboratory, Argonne, IL, USA, Department of Physics and Astronomy, University of Sheffield, Sheffield, UK, Harish-Chandra Research Institute, Allahabad, India, University of Colorado, Boulder, CO, USA, IPN Universit?? Lyon, IN2P3-CNRS, Lyon, France, Theory Division, KEK, Tsukuba, Japan, Center for High Energy Physics and Institute of Modern Physics, Tsinghua University, Beijing, China, Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA, USA, Fermi National Accelerator Laboratory, Batavia, IL, USA, Departamento de Fisica and CFTP, Instituto Superior Tecnico, Lisbon, Portugal, Department of Physics and Astronomy, University of Glasgow, Glasgow, UK, Deutsches Elektronen-Synchrotron DESY, Zeuthen, Germany, Department of Physics, National Taiwan University, Taipei, Taiwan, Paul Scherrer Institut, Villigen, Switzerland, Institut f??r Theoretische Physik, Universit??t Z??rich, Z??rich, Switzerland, LAL, Universit?? de Paris-Sud, IN2P3-CNRS, Orsay, France, Stanford Linear Accelerator Center, Stanford, CA, USA; University of Delhi, Delhi, India, Institut f??r Theoretische Physik und Astrophysik, Universit??t W??rzburg, W??rzburg, Germany, Instituto de F??sica, UNAM, M??xico, Mexico, School of Physics, Seoul National University, Seoul, Korea, Stanford Linear Accelerator Center, Stanford, CA, USA; PH Department, CERN, Geneva, Switzerland, Tata Institute of Fundamental Research, Mumbai, India, Department of Physics, University of Wisconsin, Madison, WI, USA, Instituto de F??sica Corpuscular, CSIC, Val??ncia, Spain, Department of Physics, Florida State University, Tallahassee, FL, USA, Department of Theoretical Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece, Centre for High Energy Physics, Indian Institute of Science, Bangalore, India, Institut f??r Theoretische Physik, RWTH Aachen, Aachen, Germany, Facultat de F??sica, Universitat de Barcelona, Barcelona, Spain, Department of Physics, Yonsei University, Seoul, Korea, Physikalisches Institut der Universit??t Bonn, Bonn, Germany, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA, Department of Physics, Chung-Ang University, Seoul, Korea, Department of Physics, Carleton University, Ottawa, ON, Canada, Institut f??r Theoretische Physik, Universit??t Wien, Wien, Austria, Institut f??r Theoretische Physik, Universit??t Z??rich, Z??rich, Switzerland; Instituto de F??sica Corpuscular, CSIC, Val??ncia, Spain, Department of Physics, University of Florida, Gainesville, FL, USA, Royal Holloway University of London, Egham, Surrey, UK, Department of Physics, Chonbuk National University, Chonju, Korea, Skobeltsyn Institute of Nuclear Physics, MSU, Moscow, Russia, Institute of Theoretical Physics, University of Tokushima, Tokushima, Japan, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany; I. Physikalisches Institut der RWTH Aachen, Aachen, Germany, High Energy Physics, Uppsala University, Uppsala, Sweden, ICEPP, University of Tokyo, Tokyo, Japan, YITP, Kyoto Universty, Kyoto, Japan, ITP, School of Physics, Peking University, Beijing, China, Department of Physics, University of California, Davis, CA, USA, Department of Physics, Tokyo Gakugei University, Tokyo, Japan, DAMTP, University of Cambridge, Cambridge, UK, Physics Department, Universidad Catolica de Chile, Santiago, Chile, Stanford Linear Accelerator Center, Stanford, CA, USA, INFN, Sezione di Pavia, Pavia, Italy, High Energy Physics Division, Argonne National Laboratory, Argonne, IL, USA; Enrico Fermi Institute, University of Chicago, Chicago, IL, USA, Ann Arbor, Allanach, B. C., King, S. F., Blair, G. A., Kraml, S., Kim, C. S., Bagger, J. A., Barnett, M., Ellis, J., Hou, Wei-Shu, Roy, P., Yamada, Y., Xing, Z. -Z., Hurth, T., Jiang, Y., Zerwas, P. M., Belyaev, A., Reuter, J., Langacker, Paul, Valle, J. W. F., M??hlleitner, M. M., Spira, M., Nojiri, M. M., Majerotto, W., Moortgat-Pick, G., Moretti, S., Hesselbach, S., He, H. -J., Haber, H. E., Hagiwara, K., Boos, E., Carena, M., Aguilar-Saavedra, J. A., Miller, D. J., Nowak, H., Nomura, D., Okada, N., Lafaye, R., Erler, J., Wienemann, P., Polesello, G., Jones, D. R. T., Fritzsche, T., Zerwas, D., B??langer, G., Bartl, A., Richardson, P., Rolbiecki, K., Schleper, P., Kilian, W., Rzehak, H., Kang, S. K., Yang, J. M., Bechtle, P., Freitas, A., Kane, Gordon L., Fraas, H., Kalinowski, J., Kamon, T., Jack, I., Eberl, H., Dutta, B., Dutta, S., Barger, V., Wagner, C. E. M., Ma, W. -G., Rainwater, D., Berger, E. L., Desch, K., Gounaris, G. J., Godbole, R. M., Guasch, J., Olive, K. A., Kittel, O., Klasen, M., Kr??mer, M., Logan, H. E., Zhang, R. -Y., Skands, P., Weiglein, G., Slavich, P., Zhang, X., Deppisch, F., Ali, Aejaz., Choi, S. Y., Han, T., Haba, N., Roeck, Albert De, Matchev, Konstantin T., Han, L., Heinemeyer, S., Martyn, H. -U., Moultaka, G., Mondragon, M., Sphicas, P., Mori, T., Mukhopadhyaya, B., Muanza, S., St??ckinger, D., Nauenberg, U., Tait, T., Tovey, D. R., Siyeon, K., Hidaka, K., Gunion, J., R??ckl, R., Weber, Ch., Hirsch, M., Hinchliffe, I., Djouadi, A., Peskin, M., Plehn, T., Arnowitt, R., Diaz, M. A., Baer, H. A., Porod, W., Balazs, C., Quevedo, F., Hohenwarter-Sodek, K., Kernreiter, T., Zhu, S. -H., Battaglia, Marco, ??ller, W., Hollik, W., Kovarik, K., and Kneur, J. -L.
Abstract: High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A repository for computer programs is provided which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e + e - linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles. In addition, programs for calculating high-precision low energy observables, the density of cold dark matter (CDM) in the universe as well as the cross sections for CDM search experiments are included. The SPA scheme still requires extended efforts on both the theoretical and experimental side before data can be evaluated in the future at the level of the desired precision. We take here an initial step of testing the SPA scheme by applying the techniques involved to a specific supersymmetry reference point.
Published: 2006

8. Response to Guttman & Levy's article???on the definition and varieties of attitude and wellbeing???

Author: University of Michigan, Ann Arbor, USA; University of Southampton, Southampton, UK, Ann Arbor, McKennell, Aubrey C., Andrews, Frank M., University of Michigan, Ann Arbor, USA; University of Southampton, Southampton, UK, Ann Arbor, McKennell, Aubrey C., and Andrews, Frank M.
Abstract: Guttman and Levy have prepared an extravagant critique focused mainly on the 1980 Andrews-McKennell article in this journal. The clearly stated purpose of that article was to report a???series of explorations into the affective and cognitive components of some of the more widely used measures of perceived well-being???. Guttman and Levy ignore this. They proceed on the mistaken impression that we were (or perhaps should have been) embarking upon a definitional exercise to relate the concepts of attitude and wellbeing. Yet the reason we did not cite their article on that topic was precisely because it did not address in a direct or focused way the topic that concerned us. Their critique consists of an entirely irrelevant reanalysis of some attitudinal data by Ostrom, together with a tissue of recondite definitional and methodological issues of little consequence either for the objectives or the conclusions of our research. Their dismissal of our work as???scientific retrogression??? rests on an a priori definition of science that fits their own methodological style but excludes that of many other prominent researchers. Their comments reflect an attempt at methodological imperialism. We defend our independence??? and that of other investigators??? to use promising new methodologies other than the particular approach advocated by Guttman and Levy. (Their denunciation of the new methods of structural equation modeling is not shared even by the authoritative reviewer they themselves quote.) In addition to Guttman and Levy's specific criticisms, our Response addresses general methodological issues such as the status of structural modeling and the testing of structural models. In a concluding section we identify areas that merit further research.
Published: 2006

9. Modelling of composition changes during F-region storms: a reassessment

Author: Space Physics Research Laboratory, University of Michigan, Ann Arbor, MI 48105, U.S.A., Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, U.K., Department of Physics, University of Southampton, Southampton SO9 5NH, U.K., National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307, U.S.A., Fuller-Rowell, T.J., Rees, D., Rishbeth, H., Burns, A.G., Killeen, Timothy L., Roble, Raymond Gerald, Space Physics Research Laboratory, University of Michigan, Ann Arbor, MI 48105, U.S.A., Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, U.K., Department of Physics, University of Southampton, Southampton SO9 5NH, U.K., National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307, U.S.A., Fuller-Rowell, T.J., Rees, D., Rishbeth, H., Burns, A.G., Killeen, Timothy L., and Roble, Raymond Gerald
Abstract: A recalculation of the global changes of thermospheric gas composition, resulting from strong heat inputs in the auroral ovals, shows that (contrary to some previous suggestions) widespread increases of mean molecular mass are produced at mid-latitudes, in summer and at equinox. Decreases of mean molecular mass occur at mid-latitudes in winter. Similar results are given by both the `UCL' and `NCAR TIGCM' three-dimensional models. The computed composition changes now seem consistent with the local time and seasonal response observed by satellites, and can broadly account for `negative storm effects' in the ionospheric F2-layer at mid-latitudes.
Published: 2006

10. Physician's appraisal vs documented signs and symptoms in the interpretation of food challenge tests: The EuroPrevall birth cohort

Author: [ 1 ] Robert Koch Inst, Dept Infect Dis Epidemiol, Berlin, Germany Show more [ 2 ] Charite Univ Med Berlin, Dept Dermatol Venerol & Allergol, Berlin, Germany Show more [ 3 ] German Rheumatism Res Ctr, Berlin, Germany [ 4 ] RTI Int, HTA Hlth Econ Strategy & Res, Manchester, Lancs, England Show more [ 5 ] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands Show more [ 6 ] Univ Southampton, Univ Child Hlth, Southampton, Hants, England Show more [ 7 ] Univ Southampton, Clin Expt Sci, Southampton, Hants, England Show more [ 8 ] Paediat Hosp Bambino Gesu, Dept Paediat, Rome, Italy Show more [ 9 ] Univ Athens, Dept Allergy & Clin Immunol, Pediat Clin 2, Athens, Greece Show more [ 10 ] Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England Show more [ 11 ] Hosp Univ La Paz, Alergia Infantil, Madrid, Spain [ 12 ] Med Univ, Dept Immunol Rheumatol & Allergy, Lodz, Poland [ 13 ] Landspitali, Dept Immunol, Reykjavik, Iceland Show more [ 14 ] Vilnius Univ, Fac Med, Vilnius, Lithuania Show more [ 15 ] Univ Coll, Paediat & Child Hlth, Cork, Ireland Show more [ 16 ] Charite Univ Med Berlin, Dept Paediat Pneumol & Immunol, Berlin, Germany Show more [ 17 ] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany, Department for Infectious Disease Epidemiology; Robert Koch Institute; Berlin Germany, German Rheumatism Research Center; Berlin Germany, HTA Health Economics Strategy and Research; RTI International; Manchester UK, Department of Pediatric Pulmonology & Pediatric Allergology; University of Groningen, University Medical Center Groningen; Groningen The Netherlands, University Child Health; University of Southampton; Southampton Hampshire UK, Clinical Experimental Sciences; University of Southampton; Southampton Hampshire UK, Department of Paediatrics; Paediatric Hospital Bambino Gesù; Rome Italy, Department of Allergy and Clinical Immunology; 2nd Pediatric Clinic; National & Kapodistrian University of Athens; Athens Greece, Division of Infection Immunity & Respiratory Medicine; University of Manchester; Manchester UK, Alergia Infantil; Hospital Universitario La Paz; Madrid Spain, Department of Immunology, Rheumatology and Allergy; Medical University; Lodz Poland, Department of Immunology; Landspitali - The National University Hospital of Iceland; Reykjavik Iceland, Faculty of Medicine; Vilnius University; Vilnius Lithuania, Paediatrics and Child Health; University College; Cork Ireland, Department of Paediatric Pneumology and Immunology; Charité - Universitätsmedizin Berlin; Berlin Germany, Institute for Social Medicine, Epidemiology and Health Economics; Charité - Universitätsmedizin Berlin; Berlin Germany, Grabenhenrich, Linus B., Reich, Andreas, McBride, Doreen, Sprikkelman, Aline, Roberts, Graham, Grimshaw, Kate E. C., Fiocchi, Alessandro G., Saxoni-Papageorgiou, Photini, Papadopoulos, Nikolaos G., Fiandor, Ana, Quirce, Santiago, Kowalski, Marek L., Sigurdardottir, Sigurveig T., Dubakiene, Ruta, Hourihane, Jonathan O. B., Rosenfeld, Leonard, Niggemann, Bodo, Keil, Thomas, Beyer, Kirsten, [ 1 ] Robert Koch Inst, Dept Infect Dis Epidemiol, Berlin, Germany Show more [ 2 ] Charite Univ Med Berlin, Dept Dermatol Venerol & Allergol, Berlin, Germany Show more [ 3 ] German Rheumatism Res Ctr, Berlin, Germany [ 4 ] RTI Int, HTA Hlth Econ Strategy & Res, Manchester, Lancs, England Show more [ 5 ] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands Show more [ 6 ] Univ Southampton, Univ Child Hlth, Southampton, Hants, England Show more [ 7 ] Univ Southampton, Clin Expt Sci, Southampton, Hants, England Show more [ 8 ] Paediat Hosp Bambino Gesu, Dept Paediat, Rome, Italy Show more [ 9 ] Univ Athens, Dept Allergy & Clin Immunol, Pediat Clin 2, Athens, Greece Show more [ 10 ] Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England Show more [ 11 ] Hosp Univ La Paz, Alergia Infantil, Madrid, Spain [ 12 ] Med Univ, Dept Immunol Rheumatol & Allergy, Lodz, Poland [ 13 ] Landspitali, Dept Immunol, Reykjavik, Iceland Show more [ 14 ] Vilnius Univ, Fac Med, Vilnius, Lithuania Show more [ 15 ] Univ Coll, Paediat & Child Hlth, Cork, Ireland Show more [ 16 ] Charite Univ Med Berlin, Dept Paediat Pneumol & Immunol, Berlin, Germany Show more [ 17 ] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany, Department for Infectious Disease Epidemiology; Robert Koch Institute; Berlin Germany, German Rheumatism Research Center; Berlin Germany, HTA Health Economics Strategy and Research; RTI International; Manchester UK, Department of Pediatric Pulmonology & Pediatric Allergology; University of Groningen, University Medical Center Groningen; Groningen The Netherlands, University Child Health; University of Southampton; Southampton Hampshire UK, Clinical Experimental Sciences; University of Southampton; Southampton Hampshire UK, Department of Paediatrics; Paediatric Hospital Bambino Gesù; Rome Italy, Department of Allergy and Clinical Immunology; 2nd Pediatric Clinic; National & Kapodistrian University of Athens; Athens Greece, Division of Infection Immunity & Respiratory Medicine; University of Manchester; Manchester UK, Alergia Infantil; Hospital Universitario La Paz; Madrid Spain, Department of Immunology, Rheumatology and Allergy; Medical University; Lodz Poland, Department of Immunology; Landspitali - The National University Hospital of Iceland; Reykjavik Iceland, Faculty of Medicine; Vilnius University; Vilnius Lithuania, Paediatrics and Child Health; University College; Cork Ireland, Department of Paediatric Pneumology and Immunology; Charité - Universitätsmedizin Berlin; Berlin Germany, Institute for Social Medicine, Epidemiology and Health Economics; Charité - Universitätsmedizin Berlin; Berlin Germany, Grabenhenrich, Linus B., Reich, Andreas, McBride, Doreen, Sprikkelman, Aline, Roberts, Graham, Grimshaw, Kate E. C., Fiocchi, Alessandro G., Saxoni-Papageorgiou, Photini, Papadopoulos, Nikolaos G., Fiandor, Ana, Quirce, Santiago, Kowalski, Marek L., Sigurdardottir, Sigurveig T., Dubakiene, Ruta, Hourihane, Jonathan O. B., Rosenfeld, Leonard, Niggemann, Bodo, Keil, Thomas, and Beyer, Kirsten
Abstract: To access publisher's full text version of this article click on the hyperlink below, BACKGROUND: Blinded food challenges are considered the current gold standard for the diagnosis of food allergies. We used data from a pan-European multicenter project to assess differences between study centers, aiming to identify the impact of subjective aspects for the interpretation of oral food challenges. METHODS: Nine study centers of the EuroPrevall birth cohort study about food allergy recruited 12 049 newborns and followed them for up to 30 months in regular intervals. Intensive training was conducted and every center visited to ensure similar handling of the protocols. Suspected food allergy was clinically evaluated by double-blind, placebo-controlled food challenges using a nine dose escalation protocol. The primary challenge outcomes based on physician's appraisal were compared to documented signs and symptoms. RESULTS: Of 839 challenges conducted, study centers confirmed food allergy in 15.6% to 53.6% of locally conducted challenges. Centers reported 0 to 16 positive placebo challenges. Worsening of eczema was the most common sign when challenged with placebo. Agreement between documented objective signs and the challenge outcome assigned by the physician was heterogeneous, with Cohen's kappa spanning from 0.42 to 0.84. CONCLUSIONS: These differences suggest that the comparison of food challenge outcomes between centers is difficult despite common protocols and training. We recommend detailed symptom assessment and documentation as well as objective sign-based challenge outcome algorithms to assure accuracy and comparability of blinded food challenges. Training and supervision of staff conducting food challenges is a mandatory component of reliable outcome data.

11. Remote assessment of ADHD in children and adolescents : recommendations from the European ADHD Guidelines Group following the clinical experience during the COVID-19 pandemic

Author: Santosh, P., Cortese, S., Hollis, C., Bölte, S., Daley, D., Coghill, David, Holtmann, M., Sonuga-Barke, E. J. S., Buitelaar, J., Banaschewski, Tobias, Stringaris, A., Döpfner, M., Van der Oord, S., Carucci, S., Brandeis, D., Nagy, P., Ferrin, M., Baeyens, D., van den Hoofdakker, B. J., Purper-Ouakil, D., Ramos-Quiroga, A., Romanos, M., Soutullo, C. A., Thapar, A., Wong, I. C. K., Zuddas, A., Galera, C., Simonoff, E., Universitat Autònoma de Barcelona, University of Zurich, Institut Català de la Salut, [Santosh P] Department of Child and Adolescent Psychiatry, Institute of Psychology, Psychiatry and Neuroscience, King’s College London, London, UK. Centre for Interventional Paediatric Psychopharmacology and Rare Diseases, South London and Maudsley NHS Foundation Trust, London, UK. HealthTracker Ltd, Gillingham, Kent, UK. [Cortese S] Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK. Solent NHS Trust, Southampton, UK. Hassenfeld Children’s Hospital at NYU Langone, New York University Child Study Center, New York City, NY, USA. Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK. [Hollis C] School of Medicine, National Institute for Health Research (NIHR) MindTech Mental Health MedTech Cooperative, NIHR Nottingham Biomedical Research Centre, Institute of Mental Health, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UK. [Bölte S] Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women’s and Children’s Health, Karolinska Institute and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Curtin Autism Research Group, Curtin School of Allied Health, Curtin University, Perth, WA, Australia. [Daley D] NTU Psychology, School of Social Science, Nottingham Trent University, Nottingham, UK. [Coghill D] Departments of Paediatrics and Psychiatry, University of Melbourne, Melbourne, VIC, Australia. Murdoch Children’s Research Institute, Melbourne, VIC, Australia. Royal Children’s Hospital, Melbourne, Melbourne, VIC, Australia. [Ramos-Quiroga A] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Pandemic, European ADHD Guidelines Group (EAGG), COVID-19, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], 610 Medicine & health, Remote assessment, General Medicine, 10058 Department of Child and Adolescent Psychiatry, Perinatology and Child Health, Adolescents, COVID-19 (Malaltia), Pediatrics, Psychiatry and Mental health, Trastorn per dèficit d'atenció amb hiperactivitat, Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity [PSYCHIATRY AND PSYCHOLOGY], Assistència sanitària, Pediatrics, Perinatology and Child Health, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Developmental and Educational Psychology, ADHD, administración de los servicios de salud::gestión de la atención al paciente::prestación sanitaria [ATENCIÓN DE SALUD], trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad [PSIQUIATRÍA Y PSICOLOGÍA], 10064 Neuroscience Center Zurich, Children, Health Services Administration::Patient Care Management::Delivery of Health Care [HEALTH CARE]
Abstract: Adolescents; COVID-19; Remote assessment Adolescents; COVID-19; Avaluació a distància Adolescentes; COVID-19; Evaluación a distancia The COVID-19 pandemic led ADHD services to modify the clinical practice to reduce in-person contact as much as possible to minimise viral spread. This had far-reaching effects on day-to-day clinical practice as remote assessments were widely adopted. Despite the attenuation of the acute threat from COVID, many clinical services are retaining some remote practices. The lack of clear evidence-based guidance about the most appropriate way to conduct remote assessments meant that these changes were typically implemented in a localised, ad hoc, and un-coordinated way. Here, the European ADHD Guidelines Group (EAGG) discusses the strengths and weaknesses of remote assessment methods of children and adolescents with ADHD in a narrative review based on available data and expert opinions to highlight key recommendations for future studies and clinical practice. We conclude that going forward, despite remote working in clinical services functioning adequately during the pandemic, all required components of ADHD assessment should still be completed following national/international guidelines; however, the process may need adaptation. Social restrictions, including changes in education provision, can either mask or exacerbate features associated with ADHD and therefore assessment should carefully chart symptom profile and impairment prior to, as well as during an ongoing pandemic. While remote assessments are valuable in allowing clinical services to continue despite restrictions and may have benefits for routine care in the post-pandemic world, particular attention must be paid to those who may be at high risk but not be able to use/access remote technologies and prioritize these groups for conventional face-to-face assessments.
Published: 2023

12. Extending the phenotypes associated with <scp> TRIO </scp> gene variants in a cohort of 25 patients and review of the literature

Author: Gabriella Gazdagh, David Hunt, Anna Maria Cueto Gonzalez, Monserrat Pons Rodriguez, Ayeshah Chaudhry, Marcos Madruga, Fleur Vansenne, Deborah Shears, Aurore Curie, Eva‐Lena Stattin, Britt‐Marie Anderlid, Slavica Trajkova, Elena Sukarova Angelovska, Catherine McWilliam, Philip R. Wyatt, Mary O'Driscoll, Giles Atton, Anke K. Bergman, Pia Zacher, Leena D. Mewasingh, Antonio Gonzalez‐Meneses López, Olga Alonso‐Luengo, Htoo A. Wai, Ottilie Rohde, Pauline Boiroux, Anne Debant, Susanne Schmidt, Diana Baralle, Institut Català de la Salut, [Gazdagh G] Wessex Clinical Genetics Service, Princess Anne Hospital, University Hospital Southampton NHS Trust, Southampton, UK. Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK. [Hunt D] Wessex Clinical Genetics Service, Princess Anne Hospital, University Hospital Southampton NHS Trust, Southampton, UK. [Cueto Gonzalez AM] Servei de Genètica Clínica i Molecular, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Pons Rodriguez M] Hospital Universitari Son Espases, Palma, Illes Balears, Spain. [Chaudhry A] Department of Laboratory Medicine and Genetics, Trillium Health Partners, Mississauga, Ontario, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada. [Madruga M] Hospital Viamed Santa Angela De la Cruz, Sevilla, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: enfermedades del sistema nervioso::malformaciones del sistema nervioso [ENFERMEDADES], phenotype, Nervous System Diseases::Nervous System Malformations [DISEASES], fenómenos genéticos::variación genética::mutación::mutación de sentido erróneo [FENÓMENOS Y PROCESOS], macrocephaly, Sistema nerviós - Malalties - Aspectes genètics, Fenotip, spectrin, Anomalies cromosòmiques, GEFD, Genetic Phenomena::Phenotype [PHENOMENA AND PROCESSES], Genetics, TRIO gene, Malformacions, Genetic Phenomena::Genetic Variation::Mutation::Mutation, Missense [PHENOMENA AND PROCESSES], microcephaly, Medical Genetics, fenómenos genéticos::fenotipo [FENÓMENOS Y PROCESOS], Genetics (clinical), Medicinsk genetik
Abstract: TRIO gene; Macrocephaly; Phenotype Gen TRIO; Macrocefàlia; Fenotip Gen TRIO; Macrocefalia; Fenotipo The TRIO gene encodes a rho guanine exchange factor, the function of which is to exchange GDP to GTP, and hence to activate Rho GTPases, and has been described to impact neurodevelopment. Specific genotype-to-phenotype correlations have been established previously describing striking differentiating features seen in variants located in specific domains of the TRIO gene that are associated with opposite effects on RAC1 activity. Currently, 32 cases with a TRIO gene alteration have been published in the medical literature. Here, we report an additional 25, previously unreported individuals who possess heterozygous TRIO variants and we review the literature. In addition, functional studies were performed on the c.4394A > G (N1465S) and c.6244-2A > G TRIO variants to provide evidence for their pathogenicity. Variants reported by the current study include missense variants, truncating nonsense variants, and an intragenic deletion. Clinical features were previously described and included developmental delay, learning difficulties, microcephaly, macrocephaly, seizures, behavioral issues (aggression, stereotypies), skeletal problems including short, tapering fingers and scoliosis, dental problems (overcrowding/delayed eruption), and variable facial features. Here, we report clinical features that have not been described previously, including specific structural brain malformations such as abnormalities of the corpus callosum and ventriculomegaly, additional psychological and dental issues along with a more recognizable facial gestalt linked to the specific domains of the TRIO gene and the effect of the variant upon the function of the encoded protein. This current study further strengthens the genotype-to-phenotype correlation that was previously established and extends the range of phenotypes to include structural brain abnormalities, additional skeletal, dental, and psychiatric issues. This work was supported by grants from the Agence Nationale de la Recherche to Anne Debant (ANR-2019 TRIOTISM). Diana Baralle is supported by National Institute for Health Research (NIHR) (RP-2016-07-011) research professorship.
Published: 2023

13. Towards mapping the late Quaternary vegetation change of Europe

Author: Giesecke, T., Davis, B., Brewer, S., Finsinger, W., Wolters, S., Blaauw, M., de Beaulieu, J.-L., Binney, H., Fyfe, R.M., Gaillard, M.-J., Gil-Romera, G., van der Knaap, W.O., Kunes, P., Kühl, N., van Leeuwen, J.F.N., Leydet, M., Lotter, A.F., Ortu, E., Semmler, M., Bradshaw, R.H.W., Coastal dynamics, Fluvial systems and Global change, Dep Biologie, Palaeo-ecologie, Department of Geography, University of Liverpool-University of Liverpool, ÉcolePolytechniqueFédérale de Lausanne (EPFL), School of Architecture, Civil and Environmental, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Queen's University [Belfast] (QUB), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Palaeoecology Laboratory, University of Southampton-University of Southampton, School of Geography, Plymouth University-Plymouth University, Department of Biology and Environmental Science, Institute of Plant Sciences, University of Bern, Environnements, Dynamiques et Territoires de la Montagne (EDYTEM), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre européen de recherche et d'enseignement de géosciences de l'environnement ( CEREGE ), Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Collège de France ( CdF ) -Institut National de la Recherche Agronomique ( INRA ) -Institut national des sciences de l'Univers ( INSU - CNRS ), Institut des Sciences de l'Evolution de Montpellier ( ISEM ), Université de Montpellier ( UM ) -Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique ( CNRS ), Queen's University [Belfast] ( QUB ), Institut Méditerranéen d'Ecologie et de Paléoécologie ( IMEP ), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Centre National de la Recherche Scientifique ( CNRS ), University of Southampton [Southampton]-University of Southampton [Southampton], University of Plymouth-University of Plymouth, Institut méditerranéen de biodiversité et d'écologie marine et continentale ( IMBE ), Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Aix Marseille Université ( AMU ) -Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique ( CNRS ), Environnements, Dynamiques et Territoires de la Montagne ( EDYTEM ), Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Coastal dynamics, Fluvial systems and Global change, Dep Biologie, and Palaeo-ecologie
Subjects: 010506 paleontology, Archeology, 010504 meteorology & atmospheric sciences, [ SDV.BV.BOT ] Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDE.MCG]Environmental Sciences/Global Changes, Climate change, Plant Science, 580 Plants (Botany), 01 natural sciences, [ SDV.SA.SF ] Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, law.invention, Paleontology, [SDV.SA.SF]Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, law, Plantago lanceolata, [ SDU.ENVI ] Sciences of the Universe [physics]/Continental interfaces, environment, Radiocarbon dating, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Holocene, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Chronology, [ SDE.BE ] Environmental Sciences/Biodiversity and Ecology, EPD, European pollen database, Age-depth relationships, Age uncertainty, Palaeontology, Earth Sciences, Biogeosciences, Climate Change, Anthropology, Archaeology, Vegetation, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDE.ES]Environmental Sciences/Environmental and Society, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [ SDE.MCG ] Environmental Sciences/Global Changes, 13. Climate action, European Pollen Database, Physical geography, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Scale (map), Quaternary, Geology, [ SDE.ES ] Environmental Sciences/Environmental and Society
Abstract: 23 páginas.- Thomas Giesecke et.al., The number of well-dated pollen diagrams in Europe has increased considerably over the last 30 years and many of them have been submitted to the European Pollen Database (EPD). This allows for the construction of increasingly precise maps of Holocene vegetation change across the continent. Chronological information in the EPD has been expressed in uncalibrated radiocarbon years, and most chronologies to date are based on this time scale. Here we present new chronologies for most of the datasets stored in the EPD based on calibrated radiocarbon years. Age information associated with pollen diagrams is often derived from the pollen stratigraphy itself or from other sedimentological information. We reviewed these chronological tie points and assigned uncertainties to them. The steps taken to generate the new chronologies are described and the rationale for a new classification system for age uncertainties is introduced. The resulting chronologies are fit for most continental-scale questions. They may not provide the best age model for particular sites, but may be viewed as general purpose chronologies. Taxonomic particularities of the data stored in the EPD are explained. An example is given of how the database can be queried to select samples with appropriate age control as well as the suitable taxonomic level to answer a specific research question. The readers are reques, We wish to thank all those who have contributed data to the EPD. Keith Bennett provided valuable comments in discussions and to the manuscript.
Published: 2013

14. Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors

Author: Per Hall, Diana Eccles, Peter Dabrock, Sabine C. Linn, Tade Spranger, Peter Devilee, Judith Balmaña, Kerstin Rhiem, Stefania Boccia, Björn Schmitz-Luhn, Bettina Borisch, Christiane Woopen, Alexander Katalinic, Wolfgang Gaissmaier, Dominique Stoppa-Lyonnet, Stefanie Houwaart, Rita K. Schmutzler, Paul D.P. Pharoah, Marc van den Bulcke, Karin Kast, Jacek Gronwald, Johannes Jozef Marten van Delden, Stefan Huster, Sowmiya Moorthie, Günter Emons, Institut Català de la Salut, [Schmutzler RK] Center Familial Breast and Ovarian Cancer and Center of Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany. [Schmitz-Luhn B] Cologne Center for Ethics, Rights, Economics, and Social Sciences of Health (ceres), University of Cologne, and Research Unit Ethics, University Hospital of Cologne, Cologne, Germany. [Borisch B] Institute of Global Health, University of Geneva, Geneva, Switzerland. [Devilee P] Leids Universitair Medisch Zentrum, Universiteit Leiden, Leiden, The Netherlands. [Eccles D] Clinical Trials Unit, University of Southampton, Southampton, UK. [Hall P] Karolinska Institutet, Stockholm, Sweden. [Balmaña J] Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: ELSI ethical, Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores], medicine.medical_specialty, social implications, Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], diagnóstico::diagnóstico precoz::detección precoz del cáncer [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Review Article, Risk-adjusted prevention, técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Individual risk, Other subheadings::Other subheadings::/prevention & control [Other subheadings], Breast cancer, ddc:150, Cancer screening, Medicine, Mama - Càncer - Diagnòstic, Intensive care medicine, Settore MED/42 - IGIENE GENERALE E APPLICATA, legal, Risk adjusted, neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], Cancer prevention, business.industry, Early disease, Evidence-generating care, Mama - Càncer - Factors de risc, Increased risk, Mama - Càncer - Prevenció, Oncology, Preventive intervention, Risk-adjusted prevention · Breast cancer · Evidencegenerating care · ELSI ethical, legal, social implications, Surgery, Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Genetic risk factor, business, ELSI ethical, legal, social implications, Diagnosis::Early Diagnosis::Early Detection of Cancer [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT]
Abstract: Breast cancer; Evidence-generating care; Risk-adjusted prevention Cáncer de mama; Atención generadora de evidencia; Prevención ajustada al riesgo Càncer de mama; Atenció generadora d'evidències; Prevenció ajustada al risc Background: Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increased risk is identified. However, collecting proof of effective preventive measures, ideally by prospective randomized preventive studies, typically requires very long periods of time, while the knowledge about an increased risk immediately creates a high demand for action. Summary: Therefore, we propose a risk-adjusted prevention concept that is based on the best current evidence making needed and appropriate preventive measures available, and which is constantly evaluated through outcome evaluation, and continuously improved based on these results. We further discuss the structural and procedural requirements as well as legal and socioeconomical aspects relevant for the implementation of this concept. The project was funded by the German Federal Ministry of Health (grant No. 2515FSB401 to Rita Schmutzler and Christiane Woopen) for supporting the international expert meetings, and a grant of the EU Horizon 2020 program, BRIDGES (grant No. 634935, PI Peter Devilee, WP5-PI Rita Schmutzler), for the compilation of the most recent findings of genetic risk prediction.
Published: 2021

15. International BEAT-PCD Consensus Statement for Infection Prevention and Control for Primary Ciliary Dyskinesia in collaboration with ERN-LUNG PCD Core NETWORK and patient representatives

Author: Mieke Boon, Antonio Moreno-Galdó, Jane S. Lucas, Kim G. Nielsen, Bernhard Rindlisbacher, Woolf T. Walker, June K. Marthin, Bernard Maitre, Phil Robinson, Huda Mussaffi, Vendula Martinu, Panayiotis K. Yiallouros, Heymut Omran, Amparo Escribano, Gemma Marsh, Helle Krogh Johansen, Ernst Eber, Claire Hogg, Damien M.S. Destouches, Carmen Casaulta, Petr Pohunek, Eric G. Haarman, Deborah Snijders, Suzanne Crowley, Pediatrics, Amsterdam Reproduction & Development (AR&D), CCA - Cancer biology and immunology, Institut Català de la Salut, [Marthin JK] Danish PCD Centre Copenhagen, Paediatric Pulmonary Service, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. [Lucas JS] Primary Ciliary Dyskinesia Centre, NIHR Respiratory Biomedical Research Centre, Clinical and Experimental Science, University of Southampton, Southampton, UK. [Boon M] Dept of Paediatrics, University Hospital Gasthuisberg, Leuven, Belgium. [Casaulta C] Division of Paediatric Respiratory Medicine, University Children’s Hospital, Bern, Switzerland. [Crowley S] Paediatric Dept of Allergy and Lung Diseases, Oslo University Hospital, Oslo, Norway. [Destouches DMS] Association des Patients Ayant une Dyskinésie Ciliaire Primitive, Limeil-Brevannes, France. [Moreno-Galdó A] Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER of Rare Diseases (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores], Infeccions respiratòries en els infants, Primary Ciliary Dyskinesia, Statement (logic), Respiratory System, MULTICENTER, RECOMMENDATIONS, 0302 clinical medicine, Original Research Articles, Pandemic, STENOTROPHOMONAS-MALTOPHILIA, Infection control, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [DISEASES], 030212 general & internal medicine, Primary ciliary dyskinesia, Malalties transmissibles - Transmissió, Environmental Health::Health::Environmental Illness::Communicable Diseases::Communicable Disease Control [PUBLIC HEALTH], FOUNDATION, biology, Transmission (medicine), Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Congenital Abnormalities::Abnormalities, Multiple::Ciliopathies::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Ciliary Motility Disorders [DISEASES], afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedad crónica [ENFERMEDADES], salud ambiental::salud::enfermedad ambiental::enfermedades transmisibles::control de enfermedades transmisibles [SALUD PÚBLICA], medicine.anatomical_structure, Medicine, Patient representatives, Life Sciences & Biomedicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, 610 Medicine & health, enfermedades y anomalías neonatales congénitas y hereditarias::anomalías congénitas::anomalías múltiples::ciliopatías::enfermedades y anomalías neonatales congénitas y hereditarias::trastornos de la motilidad ciliar [ENFERMEDADES], Other subheadings::Other subheadings::/prevention & control [Other subheadings], 03 medical and health sciences, otorhinolaryngologic diseases, medicine, Intensive care medicine, Science & Technology, CYSTIC-FIBROSIS, Lung, business.industry, PSEUDOMONAS-AERUGINOSA, Malalties cròniques - Prevenció, CARE, EFFICACY, medicine.disease, biology.organism_classification, respiratory tract diseases, 030228 respiratory system, Nontuberculous mycobacteria, 610 Medizin und Gesundheit, business
Abstract: Introduction In primary ciliary dyskinesia (PCD) impaired mucociliary clearance leads to recurrent airway infections and progressive lung destruction, and concern over chronic airway infection and patient-to-patient transmission is considerable. So far, there has been no defined consensus on how to control infection across centres caring for patients with PCD. Within the BEAT-PCD network, COST Action and ERS CRC together with the ERN-Lung PCD core a first initiative has now been taken towards creating such a consensus statement. Methods A multidisciplinary international PCD expert panel was set up to create a consensus statement for infection prevention and control (IP&C) for PCD, covering diagnostic microbiology, infection prevention for specific pathogens considered indicated for treatment and segregation aspects. Using a modified Delphi process, consensus to a statement demanded at least 80% agreement within the PCD expert panel group. Patient organisation representatives were involved throughout the process. Results We present a consensus statement on 20 IP&C statements for PCD including suggested actions for microbiological identification, indications for treatment of Pseudomonas aeruginosa, Burkholderia cepacia and nontuberculous mycobacteria and suggested segregation aspects aimed to minimise patient-to-patient transmission of infections whether in-hospital, in PCD clinics or wards, or out of hospital at meetings between people with PCD. The statement also includes segregation aspects adapted to the current coronavirus disease 2019 (COVID-19) pandemic. Conclusion The first ever international consensus statement on IP&C intended specifically for PCD is presented and is targeted at clinicians managing paediatric and adult patients with PCD, microbiologists, patient organisations and not least the patients and their families., For the first time ever, an international consensus statement for infection prevention and control in PCD is presented. A total of 20 statements were developed in a collaboration of BEAT-PCD, COST Action, ERS CRC and ERN-LUNG PCD Core Network. https://bit.ly/3yuahKt
Published: 2021

16. Severe Chronic Allergic (and related) Diseases: a uniform approach- a MeDALL- GA(2)LEN-ARIA Position Paper

Author: WHO Collaborating Center for Asthma, Rhinitis, Bousquet, J, Anto, Jm, Demoly, P, Schünemann, Hj, Togias, A, Akdis, M, Auffray, C, Bachert, C, Bieber, T, Bousquet, Pj, Carlsen, Kh, Casale, Tb, Cruz, Aa, Keil, T, Lodrup Carlsen KC, Maurer, M, Ohta, K, Papadopoulos, Ng, Roman Rodriguez, M, Samolinski, B, Agache, I, Andrianarisoa, A, Ang, Cs, Annesi Maesano, I, Ballester, F, Baena Cagnani CE, Basagaña, X, Bateman, Ed, Bel, Eh, Bedbrook, A, Beghe', Bianca, Beji, M, Ben Kheder, A, Benet, M, Bennoor, Ks, Bergmann, Kc, Berrissoul, F, Bindslev Jensen, C, Bleecker, Er, Bonini, S, Boner, Al, Boulet, Lp, Brightling, Ce, Brozek, Jl, Bush, A, Busse, Ww, Camargos, Pa, Canonica, Gw, Carr, W, Cesario, A, Chen, Yz, Chiriac, Am, Costa, Dj, Cox, L, Custovic, A, Dahl, R, Darsow, U, Didi, T, Dolen, Wk, Douagui, H, Dubakiene, R, El Meziane, A, Fonseca, Ja, Fokkens, Wj, Fthenou, E, Gamkrelidze, A, Garcia Aymerich, J, Gerth van Wijk, R, Gimeno Santos, E, Guerra, S, Haahtela, T, Haddad, H, Hellings, Pw, Hellquist Dahl, B, Hohmann, C, Howarth, P, Hourihane, Jo, Humbert, M, Jacquemin, B, Just, J, Kalayci, O, Kaliner, Ma, Kauffmann, F, Kerkhof, M, Khayat, G, Koffi N'Goran, B, Kogevinas, M, Koppelman, Gh, Kowalski, Ml, Kull, I, Kuna, P, Larenas, D, Lavi, I, Le, Lt, Lieberman, P, Lipworth, B, Mahboub, B, Makela, Mj, Martin, F, Martinez, Fd, Marshall, Gd, Mazon, A, Melen, E, Meltzer, Eo, Mihaltan, F, Mohammad, Y, Mohammadi, A, Momas, I, Morais Almeida, M, Mullol, J, Muraro, A, Naclerio, R, Nafti, S, Namazova Baranova, L, Nawijn, Mc, Nyembue, Td, Oddie, S, O'Hehir, Re, Okamoto, Y, Orru, Mp, Ozdemir, C, Ouedraogo, Gs, Palkonen, S, Panzner, P, Passalacqua, G, Pawankar, R, Pigearias, B, Pin, I, Pinart, M, Pison, C, Popov, Ta, Porta, D, Postma, Ds, Price, D, Rabe, Kf, Ratomaharo, J, Reitamo, S, Rezagui, D, Ring, J, Roberts, R, Roca, J, Rogala, B, Romano, A, Rosado Pinto, J, Ryan, D, Sanchez Borges, M, Scadding, Gk, Sheikh, A, Simons, Fe, Siroux, V, Schmid Grendelmeier PD, Smit, Ha, Sooronbaev, T, Stein, Rt, Sterk, Pj, Sunyer, J, Terreehorst, I, Toskala, E, Tremblay, Y, Valenta, R, Valeyre, D, Vandenplas, O, van Weel, C, Vassilaki, M, Varraso, R, Viegi, G, Wang, Dy, Wickman, M, Williams, D, Wöhrl, S, Wright, J, Yorgancioglu, A, Yusuf, Om, Zar, Hj, Zernotti, Me, Zidarn, M, Zhong, N, Zuberbier, T., Beghe', B., Fthenou, E., Boudier, Anne, Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CIBER Epidemiologia y Salud Publica, CIBER de Epidemiología y Salud Pública (CIBERESP), Universitat Pompeu Fabra [Barcelona] (UPF), WHO Collaborating Center for Asthma and Rhinitis, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations, Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Génomique fonctionnelle et biologie systémique pour la santé, Institut des Sciences Biologiques du CNRS, Upper Airway Research Laboratory (URL), Ghent University Hospital, Department of Dermatology and Allergy, VU University Medical Center [Amsterdam], Department of Paediatrics, University of Oslo (UiO)-Oslo University Hospital [Oslo], Division of Allergy and Immunology, Department of Medicine, Creighton University, ProAR - FMB, Federal University of Bahia School of Medicine, Epidemiology and Health Economics, Instittute of Social Health-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Division of Respiratory Medicine and Allergology, Teikyo University School of Medicine, Allergy Department, 2nd Pediatric Clinic, Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Department of Allergy and Clinical Immunology, Faculty of Medicine-Transylvania University, Public Hospital Medical Service, Ministry of Health [Mozambique], Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Public Health Research (CSISP), University of Valencia, Respiratory Medicine, Università degli studi di Genova = University of Genoa (UniGe)-School of Specialization, Faculty of Medicine, Catholic University, Health Sciences Faculty, University of Cape Town, Department of Pulmonology, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Centre, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Service de Pneumologie Allergologie, Hôpital La Rabta [Tunis], Service de Pneumologie, Hôpital Abderrahmen Mami, National Asthma Centre, National Institute of Diseases of the Chest and Hospital (NIDCH), Pneumologie / Anesthésie - réanimation / Oxygénothérapie, Hôpital AKS Phnom Penh-Hôpital Provincial de Siemreap, Department of Dermatology and Allergy Center, Odense University Hospital, Center for Genomics and Personalized Medicine, Wake Forest University, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli studi di Verona = University of Verona (UNIVR), Institut de cardiologie et de pneumologie, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), Department of Respiratory Medicine and Thoracic Surgery, University of Leicester-Institute for Lung Health, Department of Paediatric Respiratory Medicine, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], Department of Medicine, University of Wisconsin School of Medicine and Public Health, Department of Pediatrics, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG)-Medical School, Allergy & Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe)-Department of Internal Medicine (DIMI), Allergy & Asthma Associates, University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Deputy Scientific Director, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Department of Thoracic Surgery, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), National Cooperative Group of Pediatric Research on Asthma, Asthma Clinic and Education Center of the Capital Institute of Pediatrics, Service des Premiers Soins, Université Montpellier 1 (UM1), Osteopathic College of Medicine, Nova Southeastern University (NSU), Respiratory Research Group, University of Manchester [Manchester]-School of Translational Medicine, Department of Respiratory Diseases, Aarhus University Hospital, Department of Dermatology and Allergy Biederstein, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Service de pneumologie, Centre hospitalier de la région d'Annecy, Service de pneumo-allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Allergy Centre, Vilnius University Antakalnis Hospital, Société Marocaine des Maladies Respiratoires, Centre of Respiratory Diseases and Allergy-Centre commercial Nadia, Allergy Division, Hospital S. João-Centre for Research in Health Technologies and Information Systems (CINTESIS)-Biostatistics and Medical Informatics Department-Porto University Medical School, Department of Otorhinolaryngology, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Department of Social Medicine, University of Crete [Heraklion] (UOC)-Faculty of Medicine, Health Care, Minister Of Labour-Ministry of Labor, Health and Social Affairs, Section of Allergology, Erasmus Medical Centre, Epidemiology and Biostatistics Division, University of Arizona-Associate Research Scientist, Respiratory Sciences-Arizona Respiratory Center, Helsinki University Hospital-Skin and Allergy Hospital, Centre Hospitalier de Bigorre [Tarbes]-Association Franco-Libanaise de Pneumologie (AFLP), Department of Otorhinolaryngology, Head, and Neck Surgery, University Hospital Leuven, Engineering and the Environment, University of Southampton, Paediatrics and Child Health, University College Cork (UCC), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Pediatric Allergy and Asthma Unit, Ihsan Dogramaci Children's Hospital-Hacettepe University School of Medicine, Institute for Asthma and Allergy, George Washington University Medical School, Department of Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth (USJ)-Faculté de Médecine-Hôtel-Dieu de France, Service des Maladies Respiratoires, CHU de Cocody-UFR des Sciences Médicales, Pediatric Pulmonology, Allergology & Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Department of Clinical Immunology and Allergy, Medical University of Łódź (MUL)-Faculty ot Medicine, Centre for Allergy Research, Karolinska Institutet [Stockholm], Department of Clinical Science and Education, Division of Internal Medicine, Asthma and Allergy, Medical University of Łódź (MUL)-Barlicki University Hospital, Hospital Medica Sur, Physiology Department, University of Medicine and Pharmacy, Division of Allergy Immunology, Department of Medicine-The University of Tennessee Health Science Center [Memphis] (UTHSC), university of dundee asthma - allergic rhinitis - COPD - beta-2-adrenoceptor, University of Dundee, Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Association Franco-Vietnamienne de Pneumologie (AFVP), Centre Hospitalier de Compiègne (CHC), Arizona Respiratory Center, Department of Medicine, Clinical Immunology and Allergy, University of Mississippi Medical Center (UMMC), Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Allergy & Asthma Medical Group & Research Center, University of California [San Diego] (UC San Diego), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Internal Medicine, Tishreen University School of Medicine, Association Franco-Marocaine de Pathologie Thoracique (AFMAPATH), Collège National des Pneumologues Marocains, Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Immunoallergy Department, Hospital CUF Descobertas, Rhinology Unit & Smell Clinic, Universitat de Barcelona (UB)-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Allergy Unit, Università degli Studi di Padova = University of Padua (Unipd)-Department of Paediatrics, Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Clinique des maladies respiratoires, centre hospitalo-universitaire Mustapha Pacha d'Alger (CHUMA), Scientific Center for Children's Health, Russian Academy of Medical Sciences (RAMS), Laboratory of Allergology and Pulmonary Diseases, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Department of Pathology and Medical Biology-GRIAC Research Institute, ENT Department, University of Kinshasa (UNIKIN), Bradford Neonatology, Bradford Teaching Hospitals NHS Foundation Trust-Bradford Institute for Health Research, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Chiba University Hospital, Asthme Rhinite allergique, Pharmacie, Division of Pediatric Allergy and Immunology, marmara university, Pédiatrie, Centre Hospitalier National Pédiatrique Charles de Gaulle (CHNP-CDG), European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Immunopharmacology, Nippon Medical School-Medical Research Council Clinical, Laboratoire du Sommeil et de l'Effort, Société de Pneumologie de Langue Française (SPLF)-Clinique St George, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinic of Allergy and Asthma, Medical University Sofia-Alexander's University Hospital, Regional Health Service - Lazio, Primary Care Respiratory Medicine, University of Aberdeen-Department of General Practice and Primary Care-General Practice Airways Group (GPIAG), Department of Pulmonary Medicine, Leiden University Medical Center (LUMC), Pneumalgia, Centre Hospitalier Regional-Espace Francophone de Pneumologie (EFP)-Société de Pneumologie de l'Océan Indien (SPOI), Association Franco-Algérienne de Pneumologie (AFAP), Espace Francophone de pneumologie de la SPLF, Department of Pneumology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic de Barcelona-Institut Clínic del Tórax (ICT)-CIBER de Enfermedades Respiratorias (CIBERES)-University of Barcelona, Allergology and Clinical Immunology, Medical University of Silesia (SUM)-Chair and Clinical Department of Internal Diseases, UCSC-Allergy Unit, Complesso Integrato Columbus-Department of Internal Medicine and Geriatrics, Hospital da Luz, Medical Centre, Woodbrook Medical Centre, Research Fellow, University of Aberdeen-Department of General Practice, Centro Médico Docente La Trinidad, Department of Pharmacology, University College of London [London] (UCL)-The Royal National Throat, Nose and Ear Hospital, Primary Care Research & Development, University of Edinburgh-Centre for Population Health Sciences, Section of Allergy & Clinical Immunology, University of Manitoba [Winnipeg]-Department of Pediatrics & Child Health, Allergy Unit - Department of Dermatology, Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, School of Medicine, Pontifícia Universidade Católica, Department of ENT and Pediatrics, Finnish Institute of Occupational Health, Department of Obstetrics and Gynaecology, Université Laval [Québec] (ULaval)-Faculty of Medicine, Christian Doppler Laboratory for Allergy Research, Medizinische Universität Wien = Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Department of Chest Medicine, Mont-Godinne Hospital-Catholic University of Louvain de Mont-Godinne, Department of Primary and Community Care, Radboud University Medical Center [Nijmegen], Epidemiology Unit, National Research Council (CNR)-Institute of Biomedicine and Molecular Immunology (IBIM), Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Karolinska Institutet [Stockholm]-Sachs' Children's Hospital, GLP Analytical Facility, School of Pharmacy, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna (MUW), Celal Bayar University School of Medicine, Allergy and Asthma Clinics, The Allergy and Asthma Institute, Department of Paediatrics and Child Health, Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases-Guangzhou Medical College, Secretary General of the Global Allergy and Asthma European Network (GA2LEN), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], In collaboration with the WHO Collaborating Center for Asthma and Rhinitis, University of Genoa (UNIGE)-School of Specialization, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, University of Verona (UNIVR), Medical School-Federal University of Minas Gerais, University of Genoa (UNIGE)-Department of Internal Medicine (DIMI), University of California [Irvine] (UCI), University of California-University of California, Catholic University Rome, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Centre Hospitalier de Bigorre (Tarbes)-Association Franco-Libanaise de Pneumologie (AFLP), CUF-Descobertas Hospital, Universita degli Studi di Padova-Department of Paediatrics, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Centro Medico-Docente La Trinidad, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Instittute of Social Health, Department of Internal Medicine (DIMI)-University of Genoa (UNIGE), Medical University of Silesia-Chair and Clinical Department of Internal Diseases, Dermatology, Internal Medicine, Immunology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Research in Environmental Epidemiology ( CREAL ), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Universitat Pompeu Fabra [Barcelona], WHO(OMS), Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), National Institute of Allergy and Infectious Diseases [Bethesda], National Institutes of Health ( NIH ), Swiss Institute of Allergy and Asthma Research ( SIAF ), University of Zürich [Zürich] ( UZH ), Upper Airway Research Laboratory ( URL ), University Medical Center, University of Oslo ( UiO ) -Oslo University Hospital, Charite-Universitatsmedizin Berlin [Berlin]-Instittute of Social Health, Medical School-Charité - University Medicine Berlin, Medical University of Warsaw-Faculté de Pharmacie de Paris, Ministry of Health, Epidémiologie des maladies infectieuses et modélisation ( ESIM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Public Health Research ( CSISP ), University of Genoa ( UNIGE ) -School of Specialization, University of Amsterdam [Amsterdam] ( UvA ) -Academic Medical Centre, University of Southampton [Southampton]-School of Medicine, Hôpital La Rabta [Tunis), Wake Forest University Health Sciences, CNR, Rome, Italy and Department of Medicine-Second University of Naples, Università degli Studi di Verona, Université Laval-l'Hôpital Laval, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, University of Genoa ( UNIGE ) -Department of Internal Medicine (DIMI), Southern California Research, Université Montpellier 1 ( UM1 ), Nova Southeastern University, Technische Universität München [München] ( TUM ), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ) -University of Amsterdam [Amsterdam] ( UvA ), University of Crete ( UOC ) -Faculty of Medicine, University of Southampton [Southampton], UUniversity College Cork - National University of Ireland, Cork (UCC), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], University of Groningen [Groningen]-University Medical Center Groningen-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth ( USJ ) -Faculté de Médecine-Hôtel-Dieu de France, University of Groningen [Groningen]-University Medical Center Groningen-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Medical University of Łódź ( MUL ) -Faculty ot Medicine, Medical University of Łódź ( MUL ) -Barlicki University Hospital, Department of Medicine-University of Tennessee College for Medicine, Association Franco-Vietnamienne de Pneumologie ( AFVP ), University of Mississippi Medical Center, University of California [San Diego] ( UC San Diego ), Association Franco-Marocaine de Pathologie Thoracique ( AFMAPATH ), Epidémiologie Environnementale : Impact Sanitaire des Pollutions ( EA 4064 ), Université Paris Descartes - Paris 5 ( UPD5 ), Universitat de Barcelona ( UB ) -Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Section of Otolaryngology-Head & Neck Surgery ( OHNS ), University of Groningen [Groningen]-University Medical Center Groningen-Department of Pathology and Medical Biology-GRIAC Research Institute, University Hospital of Kinshasa, European Federation of Allergy ( EFA ), Institut d'oncologie/développement Albert Bonniot de Grenoble ( INSERM U823 ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Bioenergétique fondamentale et appliquée ( LBFA ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of General Practice and Primary Care-General Practice Airways Group (GPIAG)-University of Aberdeen, Association Franco-Algérienne de Pneumologie ( AFAP ), Department of General Practice-University of Aberdeen, University College of London [London] ( UCL ) -The Royal National Throat, Nose and Ear Hospital, University Medical Center Utrecht, Faculty of Medicine-Laval University [Québec], Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, National University of Singapore ( NUS ) -Yong Loo Lin School of Medicine, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases ( DIAID ), Secretary General of the Global Allergy and Asthma European Network ( GA2LEN ), Network of Excellence, Charité - Universitätsmedizin Berlin, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR), Universiteit Leiden-Universiteit Leiden, and Medizinische Universität Wien = Medical University of Vienna
Subjects: MESH: Asthma, severity, MESH: Comorbidity, Comorbidity, Severity of Illness Index, urticaria, MESH : Chronic Disease, MESH: Practice Guidelines as Topic, MESH : Dermatitis, Atopic, MESH: Urticaria, risk, 216-31 [Rhinitis, atopy, allergen Int Arch Allergy Immunol. 2012,158(3)], atopic dermatitis, MESH : Rhinitis, MESH: Rhinitis, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Effective primary care and public health [NCEBP 7], Immunoglobulin E - Asthma - Rhinitis - Rhinosinusitis - Urticaria - Atopic dermatitis, MESH : Practice Guidelines as Topic, Practice Guidelines as Topic, MESH : Comorbidity, MESH : Severity of Illness Index, IgE, MESH: Sinusitis, MESH : Urticaria, MESH: Hypersensitivity, macromolecular substances, MESH : Asthma, Dermatitis, Atopic, rhinitis, SDG 3 - Good Health and Well-being, MESH: Dermatitis, Atopic, MESH: Severity of Illness Index, Hypersensitivity, Humans, Sinusitis, rhinosinusitis, MESH : Hypersensitivity, MESH: Humans, MESH: Chronic Disease, MESH : Humans, Asthma, Atopic dermatitis, Immunoglobulin E, Rhinitis, Rhinosinusitis, Urticaria, asthma, allergy, MESH : Sinusitis, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Chronic Disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, control
Abstract: Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel
Published: 2012

17. Validation of living with chronic illness scale in a type 2 diabetes mellitus population

Author: Leire Ambrosio, Silvia Corchon, Jorge Caro-Bautista, Eva Timonet-Andreu, David Pérez-Manchón, Gloria Carvajal-Carrascal, Carmen Rodriguez-Blazquez, Alejandra Fuentes-Ramírez, Marta Aranda-Gallardo, Ministerio de Ciencia, Innovación y Universidades (España), European Regional Development Fund, [Caro-Bautista,J] Andalusian Public Health System, District of Primary Health Care of Málaga-Valle del Guadalhorce and Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Rodríguez-Blázquez,C] National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain. [Perez-Manchon,D] Faculty of Health, Camilo José Cela University, Madrid, Spain. [Timonet-Andreu,E] Department of Cardiology, Costa del Sol Hospital and Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Carvajal-Carrascal,G, Fuentes-Ramírez,A] Facultad de Enfermería y Rehabilitación, Universidad de La Sabana, Chía, Colombia. [Corchon,S] Faculty of Nursing and Chiropody, University of Valencia, Valencia, Spain. [Aranda-Gallardo,M] Department of Internal Medicine, Costa del Sol Hospital, Marbella, Málaga, Spain. [Ambrosio,L] School of Health Sciences, NIHR ARC Wessex, University of Southampton, Southampton, United Kingdom, and This study has been funded by the Ministry of Science, Innovation and University of the Spanish Government (FEDER/Ministerio de Ciencia, Innovación y Universidades—Agencia Estatal de Investigación/ Proyecto (CSO2017-82691-R)).
Subjects: Male, Intraclass correlation, España, Chronic illness, Geographical Locations::Geographic Locations::Americas::South America::Colombia [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Surveys and Questionnaires, Medicine, Persons::Persons::Patients::Outpatients [Medical Subject Headings], education.field_of_study, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], General Medicine, Middle Aged, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Personal Satisfaction [Medical Subject Headings], Confirmatory factor analysis, Checklist, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results [Medical Subject Headings], Diabetes mellitus tipo 2, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Feasibility Studies [Medical Subject Headings], Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings], Long-term condition, Psicometría, lcsh:R858-859.7, Female, Psychometric, Clinical psychology, Adult, Population, Check Tags::Male [Medical Subject Headings], Health Care::Health Services Administration::Organization and Administration::Professional Practice::Referral and Consultation [Medical Subject Headings], Colombia, lcsh:Computer applications to medicine. Medical informatics, Estudio de validación, Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Psychometrics [Medical Subject Headings], Social support, Quality of life (healthcare), Cronbach's alpha, Study validation, Type 2 diabetes mellitus, Humans, COSMIN, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Checklist [Medical Subject Headings], Persons::Persons::Age Groups::Adult [Medical Subject Headings], education, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Research, Enfermedad crónica, Public Health, Environmental and Occupational Health, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], Reproducibility of Results, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Cross-Sectional Studies, Check Tags::Female [Medical Subject Headings], Diabetes Mellitus, Type 2, Spain, Quality of Life, Observational study, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Factor Analysis, Statistical [Medical Subject Headings], business
Abstract: Background Worldwide, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic diseases and one of those producing greatest impact on patients’ day-to-day quality of life. Our study aim is to validate the “Living with Chronic Illness Scale” for a Spanish-speaking T2DM population. Methods In this observational, international, cross-sectional study, 582 persons with T2DM were recruited in primary care and outpatient hospital consultations, in Spain and Colombia, during the period from May 2018 to June 2019. The properties analysed were feasibility/acceptability, internal consistency, reliability, precision and (structural) content-construct validity including confirmatory factor analysis. The COSMIN checklist was used to assess the methodological/psychometric quality of the instrument. Results The scale had an adequate internal consistency and test retest reliability (Cronbach’s alpha = 0.90; intraclass correlation coefficient = 0.96, respectively). In addition, the instrument is precise (standard error of measurement = 3.34, with values s = 0.56), quality of life (WHOQOL-BREF) (rs = 0.51–0.30) and ssatisfaction with life (SLS-6) (rs = 0.50–0.38). The original 26-items version of the scale did not support totally the confirmatory factor analysis. The COSMIN checklist is favourable for all the properties analysed, although weaknesses are detected for structural validity. Conclusions The LW-CI-T2DM is a valid, reliable and accurate instrument for use in clinical practice to determine how a person’s life is affected by the presence of diabetes. This instrument correlates well with the associated constructs of social support, quality of life and satisfaction. Additional research is needed to determine how well the questionnaire structure performs when robust factor analysis methods are applied.
Published: 2021

18. FIRST SEARCH FOR AN X-RAY–OPTICAL REVERBERATION SIGNAL IN AN ULTRALUMINOUS X-RAY SOURCE

Author: Gandhi, Poshak [School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2016
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19. Circles in the sea: annual courtship 'torus' behaviour of basking sharks Cetorhinus maximus identified in the eastern North Atlantic Ocean

Author: David W. Sims, Simon D. Berrow, Ken M. O'Sullivan, Nicholas J. Pfeiffer, Richard Collins, Kev L. Smith, Brianna M. Pfeiffer, Paul Connery, Shane Wasik, Lois Flounders, Nuno Queiroz, Nicolas E. Humphries, Freya C. Womersley, Emily J. Southall, The Laboratory, Marine Biological Association, Citadel Hill, Plymouth, UK, Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton, UK, Irish Basking Shark Group, Merchants Quay, Kilrush, Ireland, Marine and Freshwater Research Centre, Department of Natural Resources and the Environment, Atlantic Technological University, Galway, Ireland, SeaFever Productions, Woodview Park, Ennistymon, Ireland, MERC Ecological Consultants, Galway, Ireland, Irish Basking Shark Group, Kilkee, Ireland, Basking Shark Scotland, Oban, UK, CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade do Porto, Vairão, Portugal, BIOPOLIS Program in Genomics, Biodiversity and Land Planning, Vairão, Portugal, and David W. Sims is supported by a Marine Biological Association Senior Research Fellowship.
Subjects: Male, Marine and Freshwater Research Centre, Courtship, Sharks, Animals, Female, Seasons, Aquatic Science, Atlantic Ocean, Ecology, Evolution, Behavior and Systematics, Ecosystem
Abstract: Groups of basking sharks engaged in circling behaviour are rarely observed, and their function remains enigmatic in the absence of detailed observations. Here, underwater and aerial video recordings of multiple circling groups of basking sharks during late summer (August and September 2016–2021) in the eastern North Atlantic Ocean showed groups numbering between 6 and 23 non-feeding individuals of both sexes. Sharks swam slowly in a rotating “torus” (diameter range: 17–39 m), with individuals layered vertically from the surface to a maximum depth of 16 m. Within a torus, sharks engaged in close-following, echelon, close-flank approach or parallel-swimming behaviours. Measured shark total body lengths were 5.4–9.5 m (mean LT: 7.3 m ± 0.9 s.d.; median: 7.2 m, n = 27), overlapping known lengths of sexually mature males and females. Males possessed large claspers with abrasions that were also observed on female pectoral fins. Female body colouration was paler than that of males, similar to colour changes observed during courtship and mating in other shark species. Individuals associated with most other members rapidly (within minutes), indicating toroidal behaviours facilitate multiple interactions. Sharks interacted through fin–fin and fin–body contacts, rolling to expose the ventral surfaces to following sharks, and breaching behaviour. Toruses formed in late summer when feeding aggregations in zooplankton-rich thermal fronts switched to non-feeding following and circling behaviours. Collectively, the observations explain a courtship function for toruses. This study highlights northeast Atlantic coastal waters as a critical habitat supporting courtship reproductive behaviour of endangered basking sharks, the first such habitat identified for this species globally. (https://www.youtube.com/watch?v=7i2H1wVOmb4) yes
Published: 2022

20. The electro-mechanical effect from charge dynamics on polymeric insulation lifetime

Author: Vaughan, A. [Faculty of Physical Sciences and Engineering, University of Southampton, Southampton, SO17 1BJ (United Kingdom)]
Published: 2015
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21. X-RAY OUTBURSTS OF ESO 243-49 HLX-1: COMPARISON WITH GALACTIC LOW-MASS X-RAY BINARY TRANSIENTS

Author: Altamirano, Diego [Physics and Astronomy, University of Southampton, Southampton, Hampshire SO17 1BJ (United Kingdom)]
Published: 2015
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22. Switching kinetics of SiC resistive memory for harsh environments

Author: Jiang, L. [Faculty of Engineering and the Environment, University of Southampton, Southampton, Hampshire, United Kingdom, SO171BJ (United Kingdom)]
Published: 2015
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23. Tephra Deposition and Bonding With Reactive Oxides Enhances Burial of Organic Carbon in the Bering Sea

Author: Jack Longman, Hayley Manners, Thomas M. Gernon, Martin R. Palmer, Gernon, Thomas M., 2 School of Ocean & Earth Science University of Southampton Southampton UK, Palmer, Martin R., and Manners, Hayley R.
Subjects: Total organic carbon, Atmospheric Science, Global and Planetary Change, Environmental chemistry, ddc:551.9, Environmental Chemistry, Environmental science, Tephra, Deposition (chemistry), General Environmental Science
Abstract: Preservation of organic carbon (OC) in marine sediments exerts a major control on the cycling of carbon in the Earth system. In these marine environments, OC preservation may be enhanced by diagenetic reactions in locations where deposition of fragmental volcanic material called tephra occurs. While the mechanisms by which this process occurs are well understood, site‐specific studies of this process are limited. Here, we report a study of sediments from the Bering Sea (IODP Site U1339D) to investigate the effects of marine tephra deposition on carbon cycling during the Pleistocene and Holocene. Our results suggest that tephra layers are loci of OC burial with distinct δ13C values, and that this process is primarily linked to bonding of OC with reactive metals, accounting for ∼80% of all OC within tephra layers. In addition, distribution of reactive metals from the tephra into non‐volcanic sediments above and below the tephra layers enhances OC preservation in these sediments, with ∼33% of OC bound to reactive phases. Importantly, OC‐Fe coupling is evident in sediments >700,000 years old. Thus, these interactions may help explain the observed preservation of OC in ancient marine sediments., Plain Language Summary: The burial of organic carbon (OC) in marine sediments is one of the major carbon sinks on Earth, meaning that it removes carbon dioxide from the ocean‐atmosphere system. However, the speed at which burial occurs varies across the globe, and is dependent on a range of factors, from the amount of nutrients in the water column, to the type of sediment. Despite evidence suggesting that when tephra is deposited to the seafloor carbon burial is enhanced, very little work has been done to investigate this process. We have therefore analyzed sediments from the Bering Sea, where volcanoes from the Aleutian Islands and Kamchatka regularly deposit tephra in the ocean. We found that OC burial is indeed associated with ash deposition, and importantly, that OC is preserved in the ash layers themselves. We show here that this carbon is preserved effectively because of chemical reactions between the OC and reactive iron, which is released by the ash, creating conditions which preserve carbon for hundreds of thousands of years., Key Points: Tephra layers are loci of marine organic carbon (OC) burial with distinct carbon isotopic compositions. Preservation primarily linked to association of OC with reactive iron phases, accounting for ∼80% of all OC in tephra layers. OC‐reactive Fe coupling is observed in sediments >700,000 years old, indicating long‐term persistence of these complexes., NERC
Published: 2021

24. Anisotropic Ta{sub 2}O{sub 5} waveguide etching using inductively coupled plasma etching

Author: Charlton, Martin [Nano Research Group, Electronics and Computer Science, Faculty of Physical and Applied Sciences, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2014
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25. Unveiling the intrinsic X-ray properties of broad absorption line quasars with a relatively unbiased sample

Author: Shankar, Francesco [School of Physics and Astronomy, University of Southampton, Southampton SO17 IBJ (United Kingdom)]
Published: 2014
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26. Wavelet-based parallel dynamic mesh adaptation for magnetohydrodynamics in the AMROC framework

Author: Margarete Oliveira Domingues, Odim Mendes, Ralf Deiterding, Müller Moreira Lopes, Kai Schneider, Anna Karina Fontes Gomes, National Institute for Space Research [Sao José dos Campos] (INPE), University of Southampton, Southampton, University of Southampton, Instituto Nacional de Pesquisas Espaciais (INPE), Space Geophysics Division (DGE/CEA), Institut de Mathématiques de Marseille (I2M), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: General Computer Science, Adaptive mesh refinement, Computer science, [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, General Engineering, FOS: Physical sciences, Context (language use), [PHYS.MECA]Physics [physics]/Mechanics [physics], 010103 numerical & computational mathematics, Computational Physics (physics.comp-ph), Solver, 01 natural sciences, Computational science, 010101 applied mathematics, Wavelet, Feature (computer vision), Polygon mesh, 0101 mathematics, Adaptation (computer science), Physics - Computational Physics, Computational magnetohydrodynamics, ComputingMilieux_MISCELLANEOUS, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: Computational magnetohydrodynamics (MHD) for space physics has become an essential area in understanding the multiscale dynamics of geophysical and astrophysical plasma processes, partially motivated by the lack of space data. Full MHD simulations are typically very demanding and may require substantial computational efforts. In particular, computational space-weather forecasting is an essential long-term goal in this area, motivated for instance by the needs of modern satellite communication technology. We present a new feature of a recently developed compressible two- and three-dimensional MHD solver, which has been successfully implemented into the parallel AMROC (Adaptive Mesh Refinement in Object-oriented C++) framework with improvements concerning the mesh adaptation criteria based on wavelet techniques. The developments are related to computational efficiency while controlling the precision using dynamically adapted meshes in space-time in a fully parallel context.
Published: 2019

27. Leaf Wax Hydrogen Isotopes as a Hydroclimate Proxy in the Tropical Pacific

Author: Ashley E. Maloney, David Sear, Julian P. Sachs, Sarah Nemiah Ladd, Giorgia Camperio, Matthew Prebble, J. D. Hassall, Daniel B. Nelson, Nathalie Dubois, Peter G. Langdon, Maloney, A. E., 4 School of Oceanography University of Washington Seattle WA USA, Nelson, D. B., 6 Department of Environmental Sciences‐Botany University of Basel Basel Switzerland, Prebble, M., 7 School of Earth and Environment University of Canterbury Christchurch New Zealand, Camperio, G., 1 Swiss Federal Institute of Aquatic Science and Technology (EAWAG) Dept. of Surface Waters—Research and Management Dübendorf Switzerland, Sear, D. A., 9 School of Geography and Environmental Science University of Southampton Southampton UK, Hassall, J. D., Langdon, P. G., Sachs, J. P., and Dubois, N.
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Hydrogen, Soil Science, chemistry.chemical_element, Aquatic Science, 01 natural sciences, Proxy (climate), 0105 earth and related environmental sciences, Water Science and Technology, Tropical pacific, Wax, Ecology, Isotope, Hydrogen isotope, ddc:551, Paleontology, Forestry, 15. Life on land, 16. Peace & justice, chemistry, 13. Climate action, Environmental chemistry, visual_art, ddc:577.7, visual_art.visual_art_medium, Environmental science, Mangrove
Abstract: Hydrogen isotope ratios of sedimentary leaf waxes (δ2HWax values) are increasingly used to reconstruct past hydroclimate. Here, we add δ2HWax values from 19 lakes and four swamps on 15 tropical Pacific islands to an updated global compilation of published data from surface sediments and soils. Globally, there is a strong positive linear correlation between δ2H values of mean annual precipitation (δ2HP values) and the leaf waxes n‐C29‐alkane (R2 = 0.74, n = 665) and n‐C28‐acid (R2 = 0.74, n = 242). Tropical Pacific δ2HWax values fall within the predicted range of values based on the global calibration, and the largest residuals from the global regression line are no greater than those observed elsewhere, despite large uncertainties in δ2HP values at some Pacific sites. However, tropical Pacific δ2HWax values in isolation are not correlated with estimated δ2HP values from isoscapes or from isotope‐enabled general circulation models. Palynological analyses from these same Pacific sediment samples suggest no systematic relationship between any particular type of pollen distribution and deviations from the global calibration line. Rather, the poor correlations observed in the tropical Pacific are likely a function of the small range of δ2HP values relative to the typical residuals around the global calibration line. Our results suggest that δ2HWax values are currently most suitable for use in detecting large changes in precipitation in the tropical Pacific and elsewhere, but that ample room for improving this threshold exits in both improved understanding of δ2H variability in plants, as well as in precipitation., Plain Language Summary: Past precipitation patterns are difficult to reconstruct, limiting our ability to understand Earth’s climate system. Geochemists reconstruct past precipitation by measuring the amount of heavy hydrogen naturally incorporated into the waxy coating of leaves, which is preserved in mud that accumulates in lakes, soils, and oceans. Heavy hydrogen in leaf waxes is strongly correlated with local precipitation, allowing us to learn about rainfall intensity, temperature, and cloud movement. However, no existing calibration studies include sites from the tropical Pacific, home to the most intense rainfall on the planet and populations that rely on rain for drinking water and farming. We measured heavy hydrogen in leaf waxes from tropical Pacific islands and show that although values are within the global calibration error, no precipitation relationship exists within the region. Plant type distributions do not explain the lack of correlation, which is best attributed to poorly constrained estimates of heavy hydrogen in local rain and the relatively small range of variability within the region. At present, heavy hydrogen from ancient leaf waxes can show large changes in past precipitation, but improved process‐level understanding is needed to use this tool to understand smaller changes in the tropical Pacific and elsewhere., Key Points: Leaf wax 2H/1H ratios are correlated with mean annual precipitation 2H/1H ratios globally, but not in the tropical Pacific. Deviations from the global relationship between precipitation leaf wax 2H/1H ratios cannot be predicted from palynological assemblages. Small range and large uncertainties in estimates of tropical Pacific precipitation 2H/1H ratios likely account for poor correlations., Swiss National Science Foundation, National Science Foundation (NSF) http://dx.doi.org/10.13039/100000001, Natural Environment Research Council (NERC) http://dx.doi.org/10.13039/501100000270, Department of Education and Training, Australian Research Council (ARC) http://dx.doi.org/10.13039/501100000923, http://10.0.15.89/ethz-b-000412154
Published: 2021

28. Trace Element Biogeochemistry in the High‐Latitude North Atlantic Ocean: Seasonal Variations and Volcanic Inputs

Author: Sebastian Steigenberger, Eric P. Achterberg, Jessica K. Klar, Alex R. Baker, C. Mark Moore, Toste Tanhua, Douglas S. Hamilton, Thomas J. Browning, Chris M. Marsay, Stuart C. Painter, Lucia Helena Vieira, Steigenberger, Sebastian, 1 Ocean and Earth Science, National Oceanography Centre Southampton University of Southampton Southampton UK, Klar, Jessica K., 4 Centre de Formation et de Recherche sur les Environnements Méditerranéens (CEFREM), UMR 5110, Université de Perpignan Via Domitia, CNRS Perpignan France, Browning, Thomas J., 2 GEOMAR Helmholtz Centre for Ocean Research Kiel Kiel Germany, Marsay, Chris M., 5 Skidaway Institute of Oceanography University of Georgia Savannah GA USA, Painter, Stuart C., 3 National Oceanography Centre Southampton UK, Vieira, Lúcia H., Baker, Alex R., 6 School of Environmental Sciences University of East Anglia Norwich UK, Hamilton, Douglas S., 7 Department of Earth and Atmospheric Science Cornell University Ithaca NY USA, Tanhua, Toste, and Moore, C. Mark
Subjects: 0106 biological sciences, Atmospheric Science, Global and Planetary Change, geography, 551.9, geography.geographical_feature_category, Vulcanian eruption, 010504 meteorology & atmospheric sciences, Mixed layer, 010604 marine biology & hydrobiology, Trace element, Biogeochemistry, Stratification (water), Atmospheric sciences, 01 natural sciences, Water column, Flux (metallurgy), Volcano, 13. Climate action, Environmental Chemistry, Environmental science, 14. Life underwater, 0105 earth and related environmental sciences, General Environmental Science
Abstract: We present dissolved and total dissolvable trace elements for spring and summer cruises in 2010 in the high‐latitude North Atlantic. Surface and full depth data are provided for Al, Cd, Co, Cu, Mn, Ni, Pb, and Zn in the Iceland and Irminger Basins, and consequences of biological uptake and inputs by the spring Eyjafjallajökull volcanic eruption are assessed. Ash from Eyjafjallajökull resulted in pronounced increases in Al, Mn, and Zn in surface waters in close proximity to Iceland during the eruption, while 3 months later during the summer cruise levels had returned to more typical values for the region. The apparent seasonal removal ratios of surface trace elements were consistent with biological export. Assessment of supply of trace elements to the surface mixed layer for the region, excluding volcanic inputs, indicated that deep winter mixing was the dominant source, with diffusive mixing being a minor source (between 13.5% [dissolved Cd, DCd] and −2.43% [DZn] of deep winter flux), and atmospheric inputs being an important source only for DAl and DZn (DAl up to 42% and DZn up to 4.2% of deep winter + diffusive fluxes) and typically less than 1% for the other elements. Elemental supply ratios to the surface mixed layer through convection were comparable to apparent removal ratios we calculated between spring and summer. Given that deep mixing dominated nutrient and trace element supply to surface waters, predicted increases in water column stratification in this region may reduce supply, with potential consequences for primary production and the biological carbon pump., Key Points: Bio‐essential element concentrations in surface waters decreased from spring to summer with removal ratios reflecting biological uptake. Effects of volcanic inputs from Eyjafjallajökull in spring 2010 were pronounced for Al, Mn, and Zn but returned to typical levels in summer. Deep winter convection dominated trace element supply to surface waters with minor contributions from atmospheric and diffusive mixing., GEOMAR Helmholtz Centre for Ocean Research Kiel http://dx.doi.org/10.13039/501100003153, Natural Environment Research Council http://dx.doi.org/10.13039/501100000270
Published: 2021

29. MEASURING THE ROTATIONAL PERIODS OF ISOLATED MAGNETIC WHITE DWARFS

Author: Knigge, Christian [School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2013
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30. Acoustofluidic phase microscopy in a tilted segmentation-free configuration

Author: Björn Hammarström, Peter Glynne-Jones, Massimo Vassalli, Gian Lucca Lippi, Julián Mejía Morales, Université Côte d’Azur, CNRS, INPHYNI, Nice, France, Department of Experimental Medicine, University of Genova, Istituto Nazionale per la Ricerca sul Cancro, Universita degli studi di Genova, Royal Institute of Technology [Stockholm] (KTH ), School of Engineering Sciences, University of Southampton, Southampton, James Watt School of Engineering [Univ Glasgow], University of Glasgow, and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI (2016)
Subjects: Microscope, Materials science, [SDV]Life Sciences [q-bio], Biomedical Engineering, Phase (waves), FOS: Physical sciences, 02 engineering and technology, 01 natural sciences, law.invention, Quantitative Biology::Cell Behavior, Colloid and Surface Chemistry, Optics, Stack (abstract data type), law, General Materials Science, Segmentation, Physics - Biological Physics, Fluid Flow and Transfer Processes, [PHYS]Physics [physics], Plane (geometry), business.industry, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Intensity (physics), Cardinal point, Biological Physics (physics.bio-ph), 0210 nano-technology, Biological imaging, business, Regular Articles
Abstract: International audience; A low-cost device for registration-free quantitative phase microscopy (QPM) based on the transport of intensity equation of cells in continuous flow is presented. The method uses acoustic focusing to align cells into a single plane where all cells move at a constant speed. The acoustic focusing plane is tilted with respect to the microscope’s focal plane in order to obtain cell images at multiple focal positions. As the cells are displaced at constant speed, phase maps can be generated without the need to segment and register individual objects. The proposed inclined geometry allows for the acquisition of a vertical stack without the need for any moving part, and it enables a cost-effective and robust implementation of QPM. The suitability of the solution for biological imaging is tested on blood samples, demonstrating the ability to recover the phase map of single red blood cells flowing through the microchip.
Published: 2021

31. Lake Sedimentary DNA Research on Past Terrestrial and Aquatic Biodiversity: Overview and Recommendations

Author: Ulrike Herzschuh, Inger Greve Alsos, Marco J. L. Coolen, Marie-Eve Monchamp, Stefan Bertilsson, Daniel Ariztegui, Antony G. Brown, Laura S. Epp, Sarah E. Crump, Aurèle Vuillemin, Mikkel Winther Pedersen, Rebecca E. Garner, Irene Gregory-Eaves, David A. Walsh, Simon Belle, Kevin Nota, Youri Lammers, Kurt H. Kjær, Liv Heinecke, Camille Thomas, Fredrik Olajos, Joanna Gauthier, Göran Englund, Liisi Talas, Isabelle Domaizon, Joanne E. Littlefair, Charlotte Clarke, Eric Capo, Anan Ibrahim, Eske Willerslev, Didier Debroas, Johan Rydberg, Y. L. Wang, Fabien Arnaud, Trisha L. Spanbauer, Peter D. Heintzman, Pierre Taberlet, Gentile Francesco Ficetola, Dilli Prasad Rijal, Charline Giguet-Covex, Richard Bindler, Laura Parducci, Alexandra Rouillard, Kathleen R. Stoof-Leichsenring, Veljo Kisand, Heike Zimmermann, Christian Bigler, Anne van Woerkom, William D. Orsi, Erwan Messager, Umeå University, Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), The Arctic University of Norway [Tromsø, Norway] (UiT), University of Copenhagen = Københavns Universitet (UCPH), Uppsala University, Department of Earth & Environmental Sciences, Ludwig-Maximilians-Universität München, 80331 Munich, GeoBio-CenterLMU, Université de Genève = University of Geneva (UNIGE), Swedish University of Agricultural Sciences (SLU), School of Geography and Environmental Science, University of Southampton, Southampton SO17 1BJ, Institute of Arctic Alpine Research [University of Colorado Boulder] (INSTAAR), University of Colorado [Boulder], Laboratoire Microorganismes : Génome et Environnement (LMGE), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Department of Environmental Science and Policy [Milano], Università degli Studi di Milano = University of Milan (UNIMI), Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Department of Biology [Concordia], Concordia University [Montreal], Groupe de recherche interuniversitaire en limnologie et en environnement aquatique - GRIL (Montréal, Canada), Université de Montréal (UdeM), Department of Biology [McGill University], McGill University = Université McGill [Montréal, Canada], ALFRED WEGENER INSTITUTE HELMHOLTZ CENTRE FOR POLAR AND MARINE RESEARCH POTSDAM DEU, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Institute of Mathematics, University of Potsdam = Universität Potsdam, Institute for Environmental Sciences and Geography, University of Potsdam, Department of Biology, University of Konstanz, Konstanz, Germany, University of Tartu, School of Biological and Chemical Sciences, Queen Mary University of London, London, UK., Department of Environmental Sciences and Lake Erie Center, University of Toledo, Toledo, OH 43606, University of Cambridge [UK] (CAM), Western Australia Organic and Isotope Geochemistry Centre, School of Earth and Planetary Sciences, the Institute for Geoscience Research (TIGeR), Curtin University, Bentley 6102, Limnological Institute, Department of Biology, University of Konstanz, 78464 Konstanz, Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques (CARRTEL), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy, Knut & Alice Wallenberg Foundation2016.0083Swedish Research Council for Sustainable Development FormasFR-2016/0005Research Council of NorwayEuropean Commission250963/F20German Research Foundation (DFG)OR 417/1-1VU 94/1-1E, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Ecology and Environmental Science, Umeå University, Environnements, Dynamiques et Territoires de la Montagne (EDYTEM), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Department of Geosciences, UiT the Arctic University of Norway, 9019 Tromsø, Section for Geogenetics, GLOBE Institute, University of Copenhagen, 1350 Copenhagen, Department of Ecology and Genetics, the Evolutionary Biology Centre, Uppsala University, 752 36 Uppsala, The Arctic University Museum of Norway, UiT the Arctic University of Norway, 9010 Tromsø, Department of Earth Sciences, University of Geneva, University of Geneva [Switzerland], Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, 75007 Uppsala, Institute of Arctic and Alpine Research (INSTAAR), Università degli Studi di Milano [Milano] (UNIMI), Department of Biology, Concordia University, Montréal, Department of Biology, McGill University, Montreal, Canada, University of Potsdam, Institute of Technology, University of Tartu, 50090 Tartu, Department of Zoology, University of Cambridge, Cambridge, United Kingdom, Willerslev, Eske [0000-0002-7081-6748], and Apollo - University of Cambridge Repository
Subjects: 0106 biological sciences, Earth science, [SDV]Life Sciences [q-bio], Biodiversity, lake sediments, Sedimentary DNA, lcsh:GN281-289, Oceanografi, hydrologi och vattenresurser, Aquatic biota, 01 natural sciences, Paleolimnology, paleoecology, Oceanography, Hydrology and Water Resources, sedimentary ancient DNA, Earth and Planetary Sciences (miscellaneous), ddc:550, lcsh:QE640-699, biodiversity, 0303 health sciences, paleolimnology, Paleogenetics, Lake sediments, VDP::Mathematics and natural science: 400::Geosciences: 450::Stratigraphy and paleontology: 461, [SDE]Environmental Sciences, lcsh:Human evolution, ancient DNA, VDP::Matematikk og Naturvitenskap: 400::Geofag: 450::Sedimentologi: 456, sedimentary DNA, paleogenetics, paleogenomics, metabarcoding, metagenomics, 010603 evolutionary biology, 03 medical and health sciences, lcsh:Stratigraphy, VDP::Mathematics and natural science: 400::Geosciences: 450::Sedimentology: 456, ddc:570, 030304 developmental biology, Earth-Surface Processes, Sedimentary ancient DNA, VDP::Matematikk og Naturvitenskap: 400::Geofag: 450::Stratigrafi og paleontologi: 461, Geokemi, Ancient DNA, Geochemistry, Paleogenomics, Metagenomics, Paleoecology, Metabarcoding, Environmental science, Sedimentary rock
Abstract: International audience; The use of lake sedimentary DNA to track the long-term changes in both terrestrial and aquatic biota is a rapidly advancing field in paleoecological research. Although largely applied nowadays, knowledge gaps remain in this field and there is therefore still research to be conducted to ensure the reliability of the sedimentary DNA signal. Building on the most recent literature and seven original case studies, we synthesize the state-of-the-art analytical procedures for effective sampling, extraction, amplification, quantification and/or generation of DNA inventories from sedimentary ancient DNA (sedaDNA) via high-throughput sequencing technologies. We provide recommendations based on current knowledge and best practises.
Published: 2021

32. THE SUZAKU VIEW OF THE DISK-JET CONNECTION IN THE LOW-EXCITATION RADIO GALAXY NGC 6251

Author: Croston, J [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom)]
Published: 2011
Full Text: View/download PDF

33. MAGNETO-ROTATIONAL NEUTRON STAR EVOLUTION: THE ROLE OF CORE VORTEX PINNING

Author: Andersson, Nils [School of Mathematics, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2011
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34. NEW OPTICAL/ULTRAVIOLET COUNTERPARTS AND THE SPECTRAL ENERGY DISTRIBUTIONS OF NEARBY, THERMALLY EMITTING, ISOLATED NEUTRON STARS

Author: Ho, W [School of Mathematics, University of Southampton, Southampton, SO17 1BJ (United Kingdom)]
Published: 2011
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35. A DWARF NOVA IN THE GLOBULAR CLUSTER M13

Author: Dieball, A [Department of Physics, University of Southampton, Southampton, S017 1BJ (United Kingdom)]
Published: 2011
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36. THE IDENTIFICATION OF MAXI J1659-152 AS A BLACK HOLE CANDIDATE

Author: Casella, P [School of Physics and Astronomy, University of Southampton, Southampton, Hampshire SO17 1BJ (United Kingdom)]
Published: 2011
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37. A CHANDRA OBSERVATION OF 3C 288-REHEATING THE COOL CORE OF A 3 keV CLUSTER FROM A NUCLEAR OUTBURST at z = 0.246

Author: Croston, J [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1SJ (United Kingdom)]
Published: 2010
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38. THE GEOMETRY AND IONIZATION STRUCTURE OF THE WIND IN THE ECLIPSING NOVA-LIKE VARIABLES RW TRI AND UX UMa

Author: Knigge, Christian [Department of Physics, University of Southampton, Southampton, S017 1BJ (United Kingdom)]
Published: 2010
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39. DIRECT OBSERVATION OF THE COOLING OF THE CASSIOPEIA A NEUTRON STAR

Author: Ho, Wynn [School of Mathematics, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2010
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40. Reducing the hidden burden of severe asthma: Recognition and referrals from primary practice

Author: Liam G Heaney, Nicola A. Hanania, Marcela Gavornikova, Arnaud Bourdin, Stephen T. Holgate, Nikolaos G. Papadopoulos, David Price, Kenneth R. Chapman, Alan Kaplan, Marc Humbert, David M.G. Halpin, Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Division of Infection, Inflammation & Respiratory Medicine, The University of Manchester, Manchester, UK, Allergy Department, 2nd Paediatric Clinic, National & Kapodistrian University of Athens, Athens, Faculty of Medicine, University of Southampton, Southampton, UK, Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, Texas, USA, Department of Respiratory Medicine, Royal Devon & Exeter Hospital, Royal Devon & Exeter Hospital, Exeter, UK, Asthma and Airway Centre, University Health Network, and University of Toronto, Toronto, Ontario, Canada., Novartis Pharma AG, Basel, Switzerland, Observational and Pragmatic Research Institute, Singapore, and University of Aberdeen, Aberdeen, UK., Family Physician Airways Group of Canada, University of Toronto, Toronto, Ontario, Canada., Queen's University [Belfast] (QUB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), National and Kapodistrian University of Athens (NKUA), Novartis Pharma AG, and MORNET, Dominique
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Health Knowledge, Attitudes, Practice, decision step process, Referral, specialist, [SDV]Life Sciences [q-bio], Primary care, Comorbidity, Severity of Illness Index, Medication Adherence, 03 medical and health sciences, chemistry.chemical_compound, primary care, 0302 clinical medicine, Adrenal Cortex Hormones, medicine, Immunology and Allergy, Humans, 030212 general & internal medicine, Intensive care medicine, Adverse effect, Referral and Consultation, Asthma, non-corticosteroid therapy, Primary Health Care, business.industry, Inhaler, Emergency department, Benralizumab, medicine.disease, systemic corticosteroids, 3. Good health, [SDV] Life Sciences [q-bio], 030228 respiratory system, chemistry, general practitioner, Pediatrics, Perinatology and Child Health, Chronic Disease, referral, business, Mepolizumab, medicine.drug, Specialization
Abstract: International audience; Since their introduction many decades ago, systemic corticosteroids have become a mainstay treatment for asthma. Despite being a highly effective therapy, corticosteroids can cause significant adverse effects in patients. This results in a "double hit" for some patients as they suffer the burden of disease as well as the burden of treatment-induced morbidity.This article aims to raise awareness of the potential, harmful side effects of prolonged or repeated exposure to systemic corticosteroids in asthma. It also highlights the importance of referral of the appropriate patients with asthma from primary care for specialist assessment once other considerations such as adherence, inhaler technique and co-morbidity have been evaluated. We propose a simple decision step that may help busy primary care physicians and general practitioners to identify patients who could benefit from specialist assessment.Our decision step suggests that a patient with asthma should be reviewed at least once by an asthma specialist if he/she (i) has received ≥2 courses of oral corticosteroids in the previous year; asthma remains uncontrolled despite good adherence and inhaler technique; or (ii) has attended an emergency department or was hospitalised for asthma care.Such referral could facilitate wider access to diagnostic tools, in-depth assessment of confounding comorbidities, and non-corticosteroid-based therapies as needed, which may be unavailable in primary practice.
Published: 2020

41. The role of Coherent Structures and Inhomogeneity in Near-Field Inter-Scale Turbulent Energy Transfers

Author: F. Alves Portela, John Christos Vassilicos, George Papadakis, School of Engineering Sciences, University of Southampton, Southampton, IMPERIAL COLLEGE LONDON DEPARTMENT OF AERONAUTICS LONDON GBR, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Laboratoire de Mécanique des Fluides de Lille – Kampé de Fériet - UMR 9014 (LMFL), Centrale Lille-ONERA-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Commission of the European Communities, Imperial College London, and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)
Subjects: Technology, CASCADE, Fluids & Plasmas, 020209 energy, Direct numerical simulation, FOS: Physical sciences, 02 engineering and technology, Mechanics, Kinetic energy, 01 natural sciences, wakes, 09 Engineering, 010305 fluids & plasmas, Physics::Fluid Dynamics, [SPI]Engineering Sciences [physics], Physics, Fluids & Plasmas, turbulence theory, 0103 physical sciences, WAKE, 0202 electrical engineering, electronic engineering, information engineering, Mean flow, EQUATIONS, 01 Mathematical Sciences, Physics, [PHYS]Physics [physics], Science & Technology, ORGANIZED WAVE, Plane (geometry), Turbulence, Mechanical Engineering, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, Fluid Dynamics (physics.flu-dyn), Physics - Fluid Dynamics, Dissipation, Condensed Matter Physics, Vortex shedding, Mechanics of Materials, Physical Sciences, Vector field
Abstract: International audience; We use Direct Numerical Simulation (DNS) data to study inter-scale and inter-space energy exchanges in the near-field of a turbulent wake of a square prism in terms of a Kármán-Howarth-Monin-Hill (KHMH) equation written for a triple decomposition of the velocity field which takes into account the presence of quasi-periodic vortex shedding coherent structures. Concentrating attention on the plane of the mean flow and on the geometric centreline, we calculate orientation-averages of every term in the KHMH equation. The near-field considered here ranges between 2 and 8 times the width d of the square prism and is very inhomogeneous and out of equilibrium so that non-stationarity and inhomogeneity contributions to the KHMH balance are dominant. The mean flow produces kinetic energy which feeds the vortex shedding coherent structures. In turn, these coherent structures transfer their energy to the stochastic turbulent fluctuations over all length-scales r from the Taylor length λ to d and dominate spatial turbulent transport of small-scale two-point stochastic turbulent fluctuations. The orientation-averaged non-linear inter-scale transfer rate Π a which was found to be approximately independent of r by Alves Portela et al. (2017) in the range λ r 0.3d at a distance x 1 = 2d from the square prism requires an inter-scale transfer contribution of coherent structures for this approximate constancy. However, the near-constancy of Π a in the range λ r d at x 1 = 8d which was also found by Alves Portela et al. (2017) is mostly attributable to stochastic fluctuations. Even so, the proximity of −Π a to the turbulence dissipation rate ε in the range λ r d at x 1 = 8d does require inter-scale transfer contributions of the coherent structures. Spatial inhomogeneity also makes a direct and distinct contribution to Π a , and the constancy of −Π a /ε close to 1 would not have been possible without it either in this near-field flow. Finally, the pressure-velocity term is also an important contributor to the KHMH balance in this near-field, particularly at scales r larger than about 0.4d, and appears to correlate with the purely stochastic non-linear inter-scale transfer rate when the orientation average is lifted.
Published: 2020

42. Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Author: Ezequiel Ruiz-Mateos, Naomi Mc Govern, Bernett Lee, Tamas Fulop, Karolina Pilipow, Tze Pin Ng, Crystal Tze Ying Tan, Shu Wen Tan, Reena Rajasuriar, Hartmut Geiger, Wilson How, Mai Chan Lau, Benoit Malleret, Amanda Amoah, Florent Ginhoux, Marie Strickland, Jin Miao Chen, Maria Carolina Florian, Glenn Wong, Enrico Lugli, Adeeba Kamarulzaman, Marion Chevrier, Veronica Zanon, Hassen Kared, Anis Larbi, Josephine Lum, [Kared,H, Tan,SW, Lau,MC, Chevrier,M, Tan,C, How,W, Wong,G, Strickland,M, Malleret,B, Govern,NM, Lum,J, Chen,JM, Lee,B, Ginhoux,F, Larbi,A] Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Republic of Singapore. [Strickland,M] Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. [Malleret,B, Larbi,A] Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. [Amoah,A, Florian,MC, Geiger,H] Institute of Molecular Medicine, University of Ulm, Ulm, Germany. [Pilipow,K, Zanon,V, Lugli,E] Humanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI), Rozzano, Italy. [Geiger,H] Experimental Hematology and Cancer Biology, CCHMC, Cincinnati, OH, USA. [Ruiz-Mateos,E] Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain. [Fulop.T, Larbi,A] Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada. [Rajasuriar,R, Kamarulzaman,A] Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia. [Rajasuriar,R] The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. [Rajasuriar,R, Kamarulzaman,A] Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. [Ng,TP] Gerontology Research Programme and Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., The study is supported by a research grant from the Agency for Science, Technology and Research (No. 10-036), by the Singapore Immunology Network and by a Starting Grant from the European Research Council (ERC-StG-2014 PERSYST 640511 to E.L.). A.L. is a scholar of International Society for Advancement of Cytometry (ISAC). R.R. and A.K. are funded by the High Impact Research/Ministry of Higher Education Research Grant, Malaysia (HIR/ MOHE, H-20001-E000001) and the RU grant (UMRG RP029-14HTM). E.R-M was supported by Consejería de Salud y Bienestar Social of Junta de Andalucía through the Nicolás Monardes Program (C-0032/17) and Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Fondos Europeos para el Desarrollo Regional, FEDER, grants PI16/ 00684, PI19/01127, RETICS, Red de Investigación en SIDA (RD16/0025/0020)., Agency for Science, Technology and Research A*STAR (Singapore), Singapore Immunology Network, European Research Council, International Society for Advancement of Cytometry, Ministry of Higher Education (Malaysia), Junta de Andalucía, Instituto de Salud Carlos III, European Commission, and Red Española de Investigación en SIDA
Subjects: 0301 basic medicine, CD4-Positive T-Lymphocytes, Aging, animal diseases, General Physics and Astronomy, HIV Infections, Signal transduction, Immunological memory, Memory T cells, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mice, 0302 clinical medicine, Organisms::Eukaryota::Animals [Medical Subject Headings], Cytotoxic T cell, Flow cytometry, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction::Wnt Signaling Pathway [Medical Subject Headings], Multidisciplinary, Wnt signaling pathway, Catenins, Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins [Medical Subject Headings], 3. Good health, Cell biology, Intercellular Signaling Peptides and Proteins, Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections [Medical Subject Headings], Stem cell, Naive T cell, Science, T cells, Context (language use), chemical and pharmacologic phenomena, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling [Medical Subject Headings], Thymus Gland, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Immune system, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors::beta Catenin [Medical Subject Headings], Antigen, Antigens, CD, Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Aging [Medical Subject Headings], Anatomy::Tissues::Lymphoid Tissue::Thymus Gland [Medical Subject Headings], Cateninas, Animals, Humans, Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD4-Positive T-Lymphocytes [Medical Subject Headings], Chemicals and Drugs::Biological Factors::Antigens [Medical Subject Headings], Anatomy::Cells::Stem Cells::Hematopoietic Stem Cells::Lymphoid Progenitor Cells::Precursor Cells, T-Lymphoid [Medical Subject Headings], Vía de señalización wnt, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Precursor Cells, T-Lymphoid, Células T de memoria, Gene Expression Profiling, General Chemistry, biochemical phenomena, metabolism, and nutrition, 030104 developmental biology, Sistema inmunológico, Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunologic Memory [Medical Subject Headings], bacteria, lcsh:Q, Citometría de flujo, Immunologic Memory, 030215 immunology
Abstract: The diversity of the naïve T cell repertoire drives the replenishment potential and capacity of memory T cells to respond to immune challenges. Attrition of the immune system is associated with an increased prevalence of pathologies in aged individuals, but whether stem cell memory T lymphocytes (TSCM) contribute to such attrition is still unclear. Using single cells RNA sequencing and high-dimensional flow cytometry, we demonstrate that TSCM heterogeneity results from differential engagement of Wnt signaling. In humans, aging is associated with the coupled loss of Wnt/β-catenin signature in CD4 TSCM and systemic increase in the levels of Dickkopf-related protein 1, a natural inhibitor of the Wnt/β-catenin pathway. Functional assays support recent thymic emigrants as the precursors of CD4 TSCM. Our data thus hint that reversing TSCM defects by metabolic targeting of the Wnt/β-catenin pathway may be a viable approach to restore and preserve immune homeostasis in the context of immunological history., Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced stem cell memory T lymphocytes, hinting the Wnt/β-catenin pathway as a potential therapy target.
Published: 2020

43. Submarine landslides around volcanic islands: A review of what can be learned from the Lesser Antilles Arc

Author: Anne Le Friant, Maya Coussens, Michael Cassidy, Sara Lafuerza, Elodie Lebas, Matthew J. Hornbach, Morgane Brunet, Sebastian F. L. Watt, Peter J. Talling, Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Christian‐Albrechts‐University of Kiel, Kiel, Germany, University of Bremen, Bremen, Germany, Sorbonne Université (SU), SMU Dedman College, Dallas, Texas, United States, University of Southampton, Southampton, United Kingdom, University of Birmingham, Birmingham, United Kingdom, Department of Earth Sciences [Oxford], University of Oxford [Oxford], Departments of Earth Sciences and Geography, University of Durham, Durham, United Kingdom, Kei Ogata, Andrea Festa, and Gian Andrea Pini
Subjects: geography, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, International Ocean Discovery Program, 010502 geochemistry & geophysics, 01 natural sciences, Arc (geometry), Volcano, Tsunami hazard, [SDU]Sciences of the Universe [physics], Seismology, Geology, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Submarine landslide
Abstract: International audience
Published: 2020

44. Ultrafast perturbation maps as a quantitative tool for testing of multi-port photonic devices

Author: Bigeng Chen, Scott Reynolds, Philippe Lalanne, Lee Crudgington, Kevin Vynck, Ali Z. Khokhar, David J. Thomson, Nicholas J. Dinsdale, Roman Bruck, Otto L. Muskens, Graham T. Reed, Laboratoire Photonique, Numérique et Nanosciences (LP2N), Université de Bordeaux (UB)-Institut d'Optique Graduate School (IOGS)-Centre National de la Recherche Scientifique (CNRS), School of Physics and Astronomy [Southampton], University of Southampton, Optoelectronics Research Centre [Southampton] (ORC), Royal Society via project 'Light shaping on a chip with nanophotonics and complexity', EPSRC through grants EP/J016918/1, EP/L00044X/1 and EP/L021129/1, LP2N_A2, LP2N_G6, Laboratoire Photonique, Numérique et Nanosciences ( LP2N ), Centre National de la Recherche Scientifique ( CNRS ) -Institut d'Optique Graduate School ( IOGS ) -Université de Bordeaux ( UB ), University of Southampton [Southampton], and Optoelectronics Research Centre [Southampton] ( ORC )
Subjects: Computer science, Science, General Physics and Astronomy, Perturbation (astronomy), FOS: Physical sciences, Physics::Optics, 02 engineering and technology, 01 natural sciences, Article, General Biochemistry, Genetics and Molecular Biology, 010309 optics, 0103 physical sciences, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Electronic engineering, Transmittance, lcsh:Science, Multi port, ComputingMilieux_MISCELLANEOUS, ComputingMethodologies_COMPUTERGRAPHICS, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Multidisciplinary, Silicon photonics, [ PHYS.PHYS.PHYS-OPTICS ] Physics [physics]/Physics [physics]/Optics [physics.optics], Condensed Matter - Mesoscale and Nanoscale Physics, business.industry, General Chemistry, 021001 nanoscience & nanotechnology, Reciprocity (electromagnetism), Device under test, lcsh:Q, Photonics, 0210 nano-technology, business, Ultrashort pulse, Physics - Optics, Optics (physics.optics)
Abstract: Advanced photonic probing techniques are of great importance for the development of non-contact wafer-scale testing of photonic chips. Ultrafast photomodulation has been identified as a powerful new tool capable of remotely mapping photonic devices through a scanning perturbation. Here, we develop photomodulation maps into a quantitative technique through a general and rigorous method based on Lorentz reciprocity that allows the prediction of transmittance perturbation maps for arbitrary linear photonic systems with great accuracy and minimal computational cost. Excellent agreement is obtained between predicted and experimental maps of various optical multimode-interference devices, thereby allowing direct comparison of a device under test with a physical model of an ideal design structure. In addition to constituting a promising route for optical testing in photonics manufacturing, ultrafast perturbation mapping may be used for design optimization of photonic structures with reconfigurable functionalities., Advanced photonic probes are important for the development of non-contact wafer-scale testing of photonic chips. Here, Vynck et al. develop a quantitative technique based on mapping of transmittance variations by ultrafast perturbations to analyze arbitrary linear multi-port photonic devices.
Published: 2018

45. Late-glacial and Holocene European pollen data

Author: Basil A. S. Davis, Steffen Wolters, Graciela Gil-Romera, Richard H. W. Bradshaw, Walter Finsinger, Ralph Fyfe, Heather Binney, Michelle Leydet, Petr Kuneš, Jacques-Louis de Beaulieu, Thomas Giesecke, Norbert Kühl, Simon Brewer, University of Utah, Georg-August-Universität Göttingen, Université de Genève ( UNIGE ), Centre de Bio-Archéologie et d'Ecologie ( CBAE ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -École pratique des hautes études ( EPHE ) -Centre National de la Recherche Scientifique ( CNRS ), University of Southampton [Southampton], Institut méditerranéen de biodiversité et d'écologie marine et continentale ( IMBE ), Centre National de la Recherche Scientifique ( CNRS ) -Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université ( AMU ) -Université d'Avignon et des Pays de Vaucluse ( UAPV ), School of Geography, University of Plymouth-University of Plymouth, Instituto Pirenaico de Ecologia, Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Steinmann-Institut für Geologie, Mineralogie und Paläontologie, Bonn Universität [Bonn], Charles University [Prague], School of Environmental Sciences, University of Liverpool, University of Liverpool, Department of Geography, University of Liverpool-University of Liverpool, ÉcolePolytechniqueFédérale de Lausanne (EPFL), School of Architecture, Civil and Environmental, Institut des Sciences de l'Evolution de Montpellier ( ISEM ), Université de Montpellier ( UM ) -Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique ( CNRS ), Institut Méditerranéen d'Ecologie et de Paléoécologie ( IMEP ), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Centre National de la Recherche Scientifique ( CNRS ), Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Aix Marseille Université ( AMU ) -Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique ( CNRS ), Georg-August-University = Georg-August-Universität Göttingen, Université de Genève = University of Geneva (UNIGE), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), University of Southampton, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Plymouth University-Plymouth University, Instituto Pirenaico de Ecologìa = Pyrenean Institute of Ecology [Zaragoza] (IPE - CSIC), Rheinische Friedrich-Wilhelms-Universität Bonn, Charles University [Prague] (CU), Georg-August-University [Göttingen], Université de Genève (UNIGE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Instituto Pirenaico de Ecologia (IPE), and Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: 010506 paleontology, 010504 meteorology & atmospheric sciences, [ SDV.BV.BOT ] Life Sciences [q-bio]/Vegetal Biology/Botanics, Geography, Planning and Development, medicine.disease_cause, 01 natural sciences, [ SDV.SA.SF ] Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, Abundance (ecology), vegetation, lcsh:G3180-9980, Pollen, Earth and Planetary Sciences (miscellaneous), medicine, [ SDU.ENVI ] Sciences of the Universe [physics]/Continental interfaces, environment, Glacial period, Environmental history, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Holocene, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, lcsh:Maps, [ SDE.BE ] Environmental Sciences/Biodiversity and Ecology, Vegetation, 15. Life on land, Europe, [ SDE.MCG ] Environmental Sciences/Global Changes, Taxon, Geography, Climatology, European Pollen Database, late-glacial, Physical geography, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, [ SDE.ES ] Environmental Sciences/Environmental and Society
Abstract: International audience; The European Pollen Database (EPD) is a community effort to archive and make available pollen sequences from across the European continent. Pollen sequences provide records that may be used to infer past vegetation and vegetation change. We present here maps based on 828 sites from the EPD giving an overview of changes in postglacial pollen assemblages in Europe over the past 15,000 years. The maps show the distribution and abundance of 54 different pollen taxa at 500 year intervals, supported by new age-depth models and associated chronological uncertainty analysis. Results show the individualistic patterns of spread of different pollen taxa, and provide a standardized dataset for further analysis, defining a spatial context for the study of past plant and vegetation changes and other aspects of environmental history in Europe.
Published: 2017

46. 2019 ARIA Care pathways for allergen immunotherapy

Author: Bousquet, J. and Pfaar, O. and Togias, A. and Schünemann, H.J. and Ansotegui, I. and Papadopoulos, N.G. and Tsiligianni, I. and Agache, I. and Anto, J.M. and Bachert, C. and Bedbrook, A. and Bergmann, K.-C. and Bosnic-Anticevich, S. and Bosse, I. and Brozek, J. and Calderon, M.A. and Canonica, G.W. and Caraballo, L. and Cardona, V. and Casale, T. and Cecchi, L. and Chu, D. and Costa, E. and Cruz, A.A. and Czarlewski, W. and Durham, S.R. and Du Toit, G. and Dykewicz, M. and Ebisawa, M. and Fauquert, J.L. and Fernandez-Rivas, M. and Fokkens, W.J. and Fonseca, J. and Fontaine, J.-F. and Gerth van Wijk, R. and Haahtela, T. and Halken, S. and Hellings, P.W. and Ierodiakonou, D. and Iinuma, T. and Ivancevich, J.C. and Jacobsen, L. and Jutel, M. and Kaidashev, I. and Khaitov, M. and Kalayci, O. and Kleine Tebbe, J. and Klimek, L. and Kowalski, M.L. and Kuna, P. and Kvedariene, V. and La Grutta, S. and Larenas-Linemann, D. and Lau, S. and Laune, D. and Le, L. and Lodrup Carlsen, K. and Lourenço, O. and Malling, H.-J. and Marien, G. and Menditto, E. and Mercier, G. and Mullol, J. and Muraro, A. and O’Hehir, R. and Okamoto, Y. and Pajno, G.B. and Park, H.-S. and Panzner, P. and Passalacqua, G. and Pham-Thi, N. and Roberts, G. and Pawankar, R. and Rolland, C. and Rosario, N. and Ryan, D. and Samolinski, B. and Sanchez-Borges, M. and Scadding, G. and Shamji, M.H. and Sheikh, A. and Sturm, G.J. and Todo Bom, A. and Toppila-Salmi, S. and Valentin-Rostan, M. and Valiulis, A. and Valovirta, E. and Ventura, M.-T. and Wahn, U. and Walker, S. and Wallace, D. and Waserman, S. and Yorgancioglu, A. and Zuberbier, T. and the ARIA Working Group, MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France, INSERM U 1168, VIMA : Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Villejuif, France, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France, Euforea, Brussels, Belgium, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany, Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany, Division of Allergy, Immunology, and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States, Department of Health Research Methods, Evidence and Impact, Division of Immunology and Allergy, McMaster University, Hamilton, ON, Canada, Hospital Quirónsalud Bizkaia, Bilbao, Spain, Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom, Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital 'P&A Kyriakou', University of Athens, Athens, Greece, Department of Social Medicine, Faculty of Medicine, University of Crete and International Primary Care Respiratory Group, Crete, Greece, Faculty of Medicine, Transylvania University, Brasov, Romania, Centre for Research in Environmental Epidemiology (CREAL), ISGlobAL, Barcelona, Spain, IMIM (Hospital del Mar Research Institute), Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, ENT Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Comprehensive Allergy Centre, Member of GA2LEN, Humboldt-Uniersität zu Berlin, Berlin, Germany, Woolcock Institute of Medical Research, Woolcock Emphysema Centre and Local Health District, University of Sydney, Glebe, NSW, Australia, Allergist, La Rochelle, France, Imperial College London - National Heart and Lung Institute, Royal Brompton Hospital NHS, London, United Kingdom, Personalized Medicine Clinic Asthma & Allergy, Humanitas Research Hospital, Humanitas University, Milan, Italy, Institute for Immunological Research, University of Cartagena, Campus de Zaragocilla, Cartagena, Colombia, Foundation for the Development of Medical and Biological Sciences (Fundemeb), Cartagena, Colombia, Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL Research Network, Barcelona, Spain, Division of Allergy/Immunology, University of South Florida, Tampa, FL, United States, SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy, UCIBIO, REQUIMTE, Faculty of Pharmacy, and Competence Center on Active and Healthy Ageing of University of Porto (AgeUPNetWork), University of Porto, Porto, Portugal, ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Salvador, Brazil, WHO GARD Planning Group, Salvador, Brazil, Medical Consulting Czarlewski, Levallois, France, Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom, Guy's and st Thomas' NHS Trust, Kings College London, London, United Kingdom, Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, United States, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan, Unité de pneumo-allergologie de l'enfant, pôle pédiatrique, CHU de Clermont-Ferrand-Estaing, Clermont-Ferrand, France, Allergy Department, IdISSC, Hospital Clinico San Carlos, Madrid, Spain, Department of Otorhinolaryngology, Academic Medical Centres, Amsterdam, Netherlands, CINTESIS, Center for Research in Health Technology and Information Systems, Faculdade de Medicina da Universidade do Porto, Porto, Portugal, Medida, Lda, Porto, Portugal, Allergist, Reims, France, Department of Internal Medicine, Section of Allergology, Erasmus MC, Rotterdam, Netherlands, Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland, Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark, Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan, Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina, Allergy Learning and Consulting, Copenhagen, Denmark, Department of Clinical Immunology, Wrocław Medical University, Wrocław, Poland, Ukrainian Medical Stomatological Academy, Poltava, Ukraine, Institute of Immunology, Federal Medicobiological Agency, Laboratory of Molecular immunology, National Research Center, Moscow, Russian Federation, Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey, Allergy & Asthma Center Westend, Berlin, Germany, Center for Rhinology and Allergology, Wiesbaden, Germany, Department of Immunology and Allergy, Healthy Ageing Research Center, Medical University of Lodz, Lodz, Poland, Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland, Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania, Faculty of Medicine, Institute of Clinical medicine, Clinic of Chest diseases and Allergology, Vilnius University, Vilnius, Lithuania, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico, Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany, KYomed INNOV, Montpellier, France, University of Medicine and Pharmacy, Hochiminh City, Viet Nam, Department of Paediatrics, Oslo University Hospital, Oslo, Norway, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Faculty of Health Sciences and CICS – UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal, Danish Allergy Centre, University of Copenhagen, Copenhagen, Denmark, CIRFF, Center of Pharmacoeconomics, University of Naples Federico II, Naples, Italy, Département de l’Information Médicale, Unité Médico-Economie, University Hospital, Montpellier, France, Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain, Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia, Department of Pediatrics, Allergy Unit, University of Messina, Messina, Italy, Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea, Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic, Allergy and Respiratory Diseases, Ospedale Policlino San Martino -University of Genoa, Genoa, Italy, Allergy Department, Pasteur Institute, Paris, France, David Hide Centre, St Mary's Hospital, Isle of Wight and University of Southampton, Southampton, United Kingdom, Department of Pediatrics, Nippon Medical School, Tokyo, Japan, Association Asthme et Allergie, Paris, France, Hospital de Clinicas, University of Parana, Parana, Brazil, Allergy and Respiratory Research Group, Medical School, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland, Allergy and Clinical Immunology Department, Centro Medico-Docente La Trinidad, Caracas, Venezuela, The Royal National TNE Hospital, University College London, London, United Kingdom, Immunomodulation and Tolerance Group, Imperial College London, London, United Kingdom, Allergy and Clinical Immunology, Imperial College London, London, United Kingdom, The Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom, Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria, Outpatient Allergy Clinic Reumannplatz, Vienna, Austria, Imunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal, Allergist, Montevideo, Uruguay, Clinic of Children's Diseases, Vilnius University Institute of Clinical Medicine, Vilnius, Lithuania, Department of Public Health, Institute of Health Sciences, Vilnius, Lithuania, European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium, Department of Lung Diseases and Clinical Immunology, Terveystalo Allergy Clinic, University of Turku, Turku, Finland, Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy, Pediatric Department, Charité, Berlin, Germany, Asthma UK, London, United Kingdom, Nova Southeastern University, Fort Lauderdale, FL, United States, Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, ON, Canada, and Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
Abstract: Allergen immunotherapy (AIT) is a proven therapeutic option for the treatment of allergic rhinitis and/or asthma. Many guidelines or national practice guidelines have been produced but the evidence-based method varies, many are complex and none propose care pathways. This paper reviews care pathways for AIT using strict criteria and provides simple recommendations that can be used by all stakeholders including healthcare professionals. The decision to prescribe AIT for the patient should be individualized and based on the relevance of the allergens, the persistence of symptoms despite appropriate medications according to guidelines as well as the availability of good-quality and efficacious extracts. Allergen extracts cannot be regarded as generics. Immunotherapy is selected by specialists for stratified patients. There are no currently available validated biomarkers that can predict AIT success. In adolescents and adults, AIT should be reserved for patients with moderate/severe rhinitis or for those with moderate asthma who, despite appropriate pharmacotherapy and adherence, continue to exhibit exacerbations that appear to be related to allergen exposure, except in some specific cases. Immunotherapy may be even more advantageous in patients with multimorbidity. In children, AIT may prevent asthma onset in patients with rhinitis. mHealth tools are promising for the stratification and follow-up of patients. © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Published: 2019

47. The dynamic coupling between piezoceramic actuators and a beam

Author: Pinnington, R [ISVR, University of Southampton, Southampton, Hampshire SO17 1BJ (United Kingdom)]
Published: 1997
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48. Late Holocene pollen record from Fiume Morto (Dead River), a palaeomeander of Tiber River near Ancient Ostia (central Italy)

Author: Valerie Andrieu-Ponel, C. Pepe, Jean-Philippe Goiran, Laura Sadori, Ferréol Salomon, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Dipartimento di biologia ambientale, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Department of Archaeology, Faculty of Humanities, University of Southampton, Southampton, Great Britain, UK, ARCHEORIENT - Environnements et sociétés de l'Orient ancien (Archéorient), Université Lumière - Lyon 2 (UL2)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), and Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]
Subjects: 010506 paleontology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, 010504 meteorology & atmospheric sciences, [SDE.MCG]Environmental Sciences/Global Changes, Aquatic Science, medicine.disease_cause, 01 natural sciences, Tiber, [SHS]Humanities and Social Sciences, law.invention, law, late holocene, Pollen, medicine, Radiocarbon dating, Sedimentology, Holocene, 0105 earth and related environmental sciences, Earth-Surface Processes, Riparian zone, Hydrology, Palynology, Central Italy, Ostia, geography.geographical_feature_category, [SDE.IE]Environmental Sciences/Environmental Engineering, Fiume Morto Tiber river delta, [SHS.GEO]Humanities and Social Sciences/Geography, fiume morto, [SDE.ES]Environmental Sciences/Environmental and Society, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Archaeology, ancient Ostia, Tiber delta, Geography, Italy, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, [SDE]Environmental Sciences, Meander, Period (geology), palynology, aquatic science, earth-surface processes, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SHS.HIST]Humanities and Social Sciences/History, Latium
Abstract: Pollen and non pollen palynomorph analyses were carried out in a sediment core (MO2) drilled in the southern lobe of a palaeomeander, Fiume Morto (Dead River), in the Tiber delta area, near Ancient Ostia (central Italy). Since the Roman period, the Tiber River flowed close to Ancient Ostia and its saltworks, Salinae Ostiensis. The Tiber meander was cut off during the Tiber River flood of 1557 AD and transformed into an oxbow lake. During the nineteenth century the Fiume Morto pond was reclaimed and at present the area is about 3 km distant from the present shoreline and intensely transformed by human settlements. According to radiocarbon dates, the pollen record, not continuous, spans from the fourth century BC to the nineteenth century AD. It shows first a riverine phase before the meander cut off of sixteenth century AD and probably only the last centuries BC were preserved from erosion. The river deposits record riparian vegetation (mainly tamarisk and alder) with mesophilous (mainly deciduous oaks) and Mediterranean (mainly evergreen oaks, heather and olive tree) elements. The human presence is clear, probably related to the development of Ancient Ostia and evidenced by synanthropic taxa. The second phase corresponds to the oxbow lake formed after the meander cut off. Several peaks of pine pollen are tentatively ascribed to Tiber flood events: the first peak is found just in correspondence with the meander cut off at 1557 AD. The numerous floods we interpret in the following part of the diagram could be linked to the increase in extreme events and precipitation that occurred during the Little Ice Age. The last phase, in which freshwater plants are present and chenopods decrease, shows the saltworks abandonment that occurred in nineteenth century. This study turned out to be of key relevance to reconstruct the palaeoenvironmental evolution of the ancient Holocene Tiber meander during the last two and a half millennia.
Published: 2016

49. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013

Author: Yong Zhao, Hadi Danawi, Bach Xuan Tran, Gene Bukhman, Vasiliki Stathopoulou, Taavi Tillmann, Nelson Alvis-Guzman, Yongmei Li, Jerry Puthenpurakal Abraham, Sudan Prasad Neupane, Jack Caravanos, Ben Schöttker, Rafael Lozano, Damian G Hoy, Yoshihiro Kokubo, Nicholas J K Breitborde, Sergey Soshnikov, Yukito Shinohara, Randall V. Martin, Michael Brainin, Fernando Perez-Ruiz, Yingfeng Zheng, Santosh Mishra, Julio Cesar Montañez Hernandez, Michael Phillips, Belinda J. Gabbe, Hebe N. Gouda, Ziad A. Memish, Rupert R A Bourne, Guoqing Hu, Emmanuel A. Ameh, Abigail McLain, Michelle L. Bell, Christopher Margono, Marissa Iannarone, Wilkister N. Moturi, Donald H. Silberberg, Carl Abelardo T. Antonio, Nataliya Foigt, Anand Dayama, Yanping Wang, Amanda J. Mason-Jones, Bolajoko O. Olusanya, Monica S. Vavilala, Katherine B Gibney, David Tanne, Sidibe S Kany Roseline, Marcella Montico, Abhishek Singh, Sarah Derrett, Alireza Esteghamati, Seok Jun Yoon, Corine Karema, Rakhi Dandona, David M. Pereira, Kazem Rahimi, Gitanjali M. Singh, Vivekanand Jha, John Hornberger, Anne M. Riederer, Kathryn H. Jacobsen, Andrea Pedroza, Lily Alexander, Fiona M. Blyth, Tommi Vasankari, Kyle J Foreman, Rana J. Asghar, Tilahun Nigatu Haregu, Yousef Khader, Rafael Alfonso-Cristancho, Suzanne Barker-Collo, Lydia S. Atkins, Simerjot K. Jassal, Mohammad Ali Sahraian, Peter Scarborough, Hans W. Hoek, E. Ray Dorsey, Muluken Dessalegn, David C. Schwebel, Gavin Shaddick, Thomas D. Fleming, Mohammad Tavakkoli, Dorairaj Prabhakaran, Mohammad H. Forouzanfar, Christopher C. Mapoma, Jost B. Jonas, Erin C Mullany, Gene F. Kwan, Johanna M. Geleijnse, Antonio Luiz Pinho Ribeiro, Roberto Tchio Talongwa, Tolesa Bekele, Jed D. Blore, Gunn Marit Aasvang, Philimon Gona, Miguel Angel Alegretti, Babak Eshrati, Mitsuru Mukaigawara, Richard F. Gillum, Odgerel Chimed-Ochir, Ubai Alsharif, Richard C. Franklin, Felix Masiye, Richard T. Burnett, Sanjay Krishnaswami, Martin McKee, John J Huang, Lucía Cuevas-Nasu, Wagner Marcenes, Walid Ammar, Knud Juel, Joseph R. Zunt, Martha M Téllez Rojo, Mamta Swaroop, Noela M Prasad, Azmeraw T. Amare, Tim Driscoll, Michael Kravchenko, Heresh Amini, Amir Sapkota, Theo Vos, Charlotte Watts, Dennis Odai Laryea, D. Alex Quistberg, Justin Beardsley, Cheng Huang, Adnan M. Durrani, Sarah V Thackway, Rita Van Dingenen, Manami Inoue, Martha Híjar, Honglei Chen, Amany H. Refaat, Yichong Li, Vineet K. Chadha, Wenzhi Wang, Louisa Degenhardt, Kingsley N. Ukwaja, Nayu Ikeda, James D. Wilkinson, Linh N Bui, Maria Hagströmer, Gonghuan Yang, Ann Kristin Knudsen, David J. Margolis, Soewarta Kosen, Hans Kromhout, Atsushi Goto, Man Mohan Mehndiratta, Thomas N. Williams, Michael Soljak, Yun Jin Kim, Hideaki Toyoshima, Jeyaraj D Pandian, Borja del Pozo-Cruz, Soufiane Boufous, Ivy Shiue, Anders Larsson, Guilherme V. Polanczyk, John Powles, Yara A. Halasa, Robin Room, Ratilal Lalloo, Carolina Batis Ruvalcaba, Panniyammakal Jeemon, Elisabete Weiderpass, Jürgen Rehm, Ejaz Ahmad Khan, Alicia Aleman, Zacharie Tsala Dimbuene, Elena Alvarez, Rachelle Buchbinder, Randah R. Hamadeh, Bryan Hubbell, Sadaf G. Sepanlou, Farhad Islami, Costas A. Christophi, Heidi Stöckl, Ismael R. Campos-Nonato, Nigel Bruce, Edward J Mills, Samuel A L Perry, Taavi Lai, Baffour Awuah, Mete Saylan, Karen J. Courville, Arindam Basu, Vanessa De la Cruz-Góngora, Teresita González de Cosío, Naohiro Yonemoto, Frida Namnyak Ngalesoni, Muluken Azage Yenesew, Atte Meretoja, Michael Brauer, Cyrus Cooper, Giorgia Giussani, Valentina S. Arsic Arsenijevic, Vasiliy Victorovich Vlassov, André Karch, Leilei Duan, Matthew M Coates, Omid Ameli, Gelin Xu, Matthias Endres, Ganesan Karthikeyan, Ione Jayce Ceola Schneider, Mohamed Hsairi, Palwasha Anwari, Mazin J. Al Khabouri, Dariush Mozaffarian, Juan R. Sanabria, Pablo M. Lavados, Sumeet S. Chugh, Johan Ärnlöv, Ivo Rakovac, Maurice Giroud, Haidong Kan, Ibrahim Abdelmageem Mohamed Ginawi, José Luis Texcalac-Sangrador, Luigi Naldi, Erica Leigh Slepak, Deena Alasfoor, James E. Saunders, Richard Matzopoulos, Talal Bakfalouni, Stein Emil Vollset, Andrea Werdecker, Lennert J. Veerman, Lorenzo Monasta, Henrica A. F. M. Jansen, Reyna A Gutiérrez, Brittany Wurtz, Luz Maria Sanchez, Lijing L. Yan, M. Patrice Lindsay, Michele Meltzer, Sanjay Basu, Steven van de Vijver, Alaa Badawi, Thomas Claßen, Young-Ho Khang, Brett M. Kissela, Jun Zhu, In-Hwan Oh, Fiona J Charlson, Maria Cecilia Bahit, Dinorah González-Castell, Rosario Cárdenas, Dan Poenaru, Sayed Saidul Alam, Mitchell T. Wallin, Harish Chander Gugnani, James Leigh, Ferrán Catalá-López, Lidia Morawska, Jim van Os, Stephanie J. London, Kaire Innos, Isabelle Romieu, Fiorella Cavalleri, Adrian Davis, Hwee Pin Phua, Chakib Nejjari, Héctor Gómez Dantés, Boris I. Pavlin, Karen Sliwa, Lynne Gaffikin, Constance D. Pond, Michael F. MacIntyre, Blake Thomson, Norberto Perico, Ronny Westerman, Samantha M. Colquhoun, Michael H. Criqui, Ana Maria Nogales Vasconcelos, Wubegzier Mekonnen, Bulat Idrisov, Ana Basto-Abreu, Andrew G. M. Bulloch, Jasvinder A. Singh, Vinod K. Paul, Emin Murat Tuzcu, Svetlana Popova, Hmwe H Kyu, Richard L. Guerrant, Mohammed I. Albittar, Srikanth Mangalam, Steven E. Lipshultz, Lela Sturua, Semaw Ferede Abera, Eduardo Bernabé, George D. Thurston, Bruno F. Sunguya, Tiffany Ku, Alejandra G. Contreras, Abdullah Sulieman Terkawi, Charles Atkinson, Ashkan Afshin, Heidi J. Larson, Abdullatif Husseini, Jose C. Adsuar, Reza Assadi, Ademola Lukman Adelekan, Joshua A. Salomon, Yousef M. Elshrek, Gokalp Kadri Yentur, Devina Nand, Narayanaswamy Venketasubramanian, Graça Maria Ferreira De Lima, Maheswar Satpathy, Fotis Topouzis, Traolach S. Brugha, Hywel C Williams, Coen H. Van Gool, Andrew H. Kemp, Awoke Misganaw, Amado D Quezada, Norito Kawakami, Bert Brunekreef, Peter Burney, Tati S. Warouw, Jongmin Lee, Inga Dora Sigfusdottir, Marcel Tanner, Solveig A. Cunningham, Benjamin O. Anderson, Tariku Jibat Beyene, Lars Barregard, Xia Wan, Giuseppe Remuzzi, Bernadette Thomas, Lilia S Pedraza, Massimo Cirillo, Alina Rodriguez, Ricky Leung, Farshad Pourmalek, K. Srinath Reddy, Charles D.A. Wolfe, Ulrich O Mueller, Neeraj Bedi, Al Artaman, Lucia Hernandez, Itamar S. Santos, C. Arden Pope, Norlinah Mohamed Ibrahim, Carlo Irwin A. Panelo, Selen Begüm Uzun, Miltiadis K. Tsilimbaris, Anwar Rafay, Daniel Dicker, Melvin Barrientos Marzan, Sajjad Ur Rahman, Mohammed O. Basulaiman, Edgar P. Simard, Mohammad T Mashal, Maysaa El Sayed Zaki, Shiwei Liu, Don C. Des Jarlais, Bo Norrving, Salvador Villalpando, Miia Kivipelto, Yang Liu, Carolina Maria Teixeira, Catalina Medina, Sudha Jayaraman, Josep Maria Haro, Diego De Leo, Angel J Paternina Caicedo, Abigail C. McKay, Eric L. Ding, Mukesh Dherani, Ljiljana Pejin Stokic, Vinay Nangia, Sukanta Saha, Juan Liang, Elisabeth Cardis, Zourkaleini Younoussi, José R Nogueira, Braden Te Ao, Vasco Manuel Pedro Machado, Lionel Racapé, Ting Wu Chuang, Shahab Khatibzadeh, E Filipa de Castro, Barthelemy Kuate Defo, Ulises Trujillo, Alan D. Lopez, Soraya Seedat, Lope H Barrero, Linhong Wang, Daniel Pope, Alexandra Brazinova, Faris Lami, Valentina Colistro, G Anil Kumar, Derek F J Fay, Haidong Wang, Hwashin H. Shin, Raimundas Lunevicius, Suzanne Polinder, Dietrich Plass, David Rojas-Rueda, Stephen S Lim, Tania G Sánchez-Pimienta, K.M. Venkat Narayan, Yuantao Hao, Jung-Chen Chang, Corina Benjet, Seyed-Mohammad Fereshtehnejad, Luciano A. Sposato, Stan Biryukov, Kunihiro Matsushita, Beth E. Ebel, Cleusa P. Ferri, Soumya Swaminathan, K. Ryan Wessells, Gustavo Velasquez-Melendez, Leslie T. Cooper, David O. Carpenter, Nancy Lopez, Bryan L. Sykes, Sandra Nolte, Murray B. Stein, Paul N. Jensen, Fabiola Mejía-Rodríguez, Xiaonong Zou, Bradford D. Gessner, Dhruv S. Kazi, Dragos Virgil Davitoiu, Alejandra Jáuregui, Pouria Heydarpour, Megan Bohensky, Harvey Whiteford, Berrak Bora Basara, Zhengming Chen, Gregory R. Wagner, Paul I. Dargan, Hermann Brenner, Nima Hafezi-Nejad, John Nelson Opio, Scott Weichenthal, Deborah Salvo, Jun She, Tea Lallukka, Carolyn C. Gotay, Stephen G. Waller, Christian Kieling, Shivanthi Balalla, Valery L. Feigin, Qing Lan, Matias Trillini, Adam D M Briggs, Sungroul Kim, Niveen M E Abu-Rmeileh, Renata Micha, Sergey Petrovich Ermakov, Ole Frithjof Norheim, Zulfiqar A Bhutta, Paul S. F. Yip, Grant Nguyen, Ralph L. Sacco, Biju Abraham, Ken Takahashi, Jixiang Ma, Peter A. Meaney, Ayse Abbasoglu Ozgoren, Kimberly Cooperrider, M Rifat Kose, Shams Eldin Ali Hassan Khalifa, Rasmus Havmoeller, Alize J. Ferrari, Kebede Deribe, Nadim E. Karam, George A. Mensah, Bongani M. 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Thrift, Stefan Ma, Samaya Ismayilova, Evariste Gasana, Amitava Banerjee, Aslam Pervaiz, Emilie Agardh, Abraham D. Flaxman, Farshad Farzadfar, Peter W. Gething, Ileana Heredia-Pi, Boris Bikbov, Wanqing Chen, Saad B. Omer, Ruben Castro, Neeraj Bhala, Sara Sheikhbahaei, Hilton Lam, Urbano Fra Paleo, Lidia Sanchez-Riera, Alicia Elena Beatriz Lawrynowicz, Kristen Delwiche, Richard G. Ellenbogen, Max Petzold, Yuri Y Varakin, Guilherme Borges, Guohong Jiang, Francis Guillemin, Kyle R. Heuton, Yohannes Kinfu, Victoria F Bachman, Joseph A Wagner, Carlos A Castañeda-Orjuela, Leonardo Trasande, Abbas Ali Mahdi, Josef Coresh, Chuanhua Yu, Kenji Shibuya, Berrin Serdar, Laetitia Huiart, Xiaofeng Liang, Jean de Dieu Ngirabega, Takayoshi Ohkubo, Natalie Stephens, Francis Apolinary Mhimbira, Jefferson Traebert, Amiran Gamkrelidze, Kjetil Søreide, Samath D Dharmaratne, Robert P. Dellavalle, George Mugambage Ruhago, Lakshmi Vijayakumar, Joannie Lortet-Tieulent, Dipan Bose, Tania C Aburto, Saleem M Rana, Miriam Levi, Mohammad Taghi Hedayati, Rodolfo S Pagcatipunan, Ron T. Gansevoort, H. D. Hosgood, Michael Burch, Mohsen Naghavi, Vegard Skirbekk, Ayfer Pekericli, Walter Mendoza, Pengpeng Ye, Gabrielle deVeber, Ali H. Mokdad, David M. Broday, Koranteng Adofo, Zewdie Aderaw Alemu, Shifalika Goenka, Carrie Beth Peterson, Nicolas J. C. Stapelberg, Edson Serván-Mori, Anil Kaul, Foad Abd-Allah, Marek Majdan, Rahul Gupta, Giancarlo Logroscino, Kardiyoloji, Peterson, Carrie B., Laboratoire de Physique des Solides (LPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Wisconsin Division of Public Health, Laboratoire de psychologie sociale et de psychologie cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), London South Bank University, Metropolitan Police Service, Hong Kong Baptist University (HKBU), Institut für Informatik [München/Munich] (LMU), Ludwig-Maximilians-Universität München (LMU), Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Insight Centre for Data Analytics [Galway] (INSIGHT), National University of Ireland [Galway] (NUI Galway), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Karolinska Institute, karolinska institute, Department of Molecular Biosciences, Department of Molecular Biosciences [Oslo], Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Centro de Estudios Avanzados en Zonas Aridas (CEAZA), Ecole Polytechnique Fédérale de Lausanne (EPFL), Regional Genetic Service, St Mary's Hospital, Manchester, Laboratoire d'Ingénierie des Matériaux (LIM), Centre National de la Recherche Scientifique (CNRS), Computer Science Department [Bristol], University of Bristol [Bristol], Universität Mannheim [Mannheim], Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Samsung Research &Development Institute India - Bangalore (Groupe Samsung) (SRI-B), Computational Science and Engineering Department [Daresbury] (STFC), Science & Technologie Facilities Council, Multimedia Research Center (MRC), University of Alberta, Division of Biostatistics (Biostat - MINNEAPOLIS), University of Minnesota [Twin Cities], University of Minnesota System-University of Minnesota System, University of Southampton, Imperial College London, Neurology Department, Ichilov Medical Center, Interactions, transferts, ruptures artistiques et culturels - EA 6301 (InTRu), Université de Tours, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], Risk Assessment Sciences Institute, Utrecht University [Utrecht], Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Respiratory Epidemiology and Public Health, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], CIBER de Epidemiología y Salud Pública (CIBERESP), STAR laboratory, Stanford University [Stanford], Unité de recherche Virologie et Immunologie Moléculaires (VIM), Institut National de la Recherche Agronomique (INRA), Tennent Institute of Ophthalmology, National University of Singapore (NUS), Centre de Robotique (CAOR), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Multidisciplinary Nanotechnology Centre, Swansea University, Cyprus International Institute for the Environment and Public Health, Harvard School of Public Health, Genomics Research Center, Academia Sinica, Neuro Rehab Services LLP [New Delhi], Department of Signal Theory and Communications (TSC), Univ. Politec. de Catalunya, King‘s College London, Dept. Mat. Engn. De Ma, Sao Carlos, Fed. Univ. Sao Carlos UFSCar, RESPEC (RESPEC), RESPEC, Advanced Laboratories on Embedded Systems [Roma] (ALES), Department of Biology [Miami], University of Miami [Coral Gables], Health Care, Minister Of Labour-Ministry of Labor, Health and Social Affairs, Department of Nephrology, University Medical Center, University of Groningen, Division of Human Nutrition, Wageningen University and Research Centre [Wageningen] (WUR), Spatial Ecology and Epidemiology Group, University of Oxford [Oxford], College of Medicine, University of Hail, Saudi Arabia, Laboratory of Neurologic Diseases, Mario Negri Institute, Milan, Department of Civil Engineering [Hamirpur], National Institute of Technology [Hamirpur], GEMMA — Environmental Engineering and Microbiology Research Group, Department of Hydraulic, Maritime and Environmental Engineering, Universitat Politècnica de Catalunya [Barcelona] (UPC), Department of Biosciences and Nutrition, Karolinska Institutet [Stockholm], Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Institut National de Recherche et d'Analyse Physico-chimique (Ariana, Tunisie) (INRAP), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Shahid Beheshti University-Shahid Beheshti University, Center for Applied Medical Research (CIMA), University of Tehran, Secretariat of the Pacific Community, Public Health Division, Sociétés, Acteurs, Gouvernement en Europe (SAGE), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), College of Precision Instrument and Optoelectronics Engineering, Tianjin University, George Washington University (GW), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universiteit Gent [Ghent], Washington State University (WSU), Laboratoire de Physique de l'ENS Lyon (Phys-ENS), École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, School of Computer Science - China University of Geosciences (China University of Geosciences (East Area)), Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Catholique de Louvain (UCL), Fachbereich Physik [Berlin], Freie Universität Berlin, Div Cyclotron & Radiopharmaceut Sci (DRDO, INMAS), Univ New Delhi, School of Physics and Astronomy, University of St Andrews [Scotland], University of Cape Town, Department of Neuroscience, Department of Computer Science and Engineering [Daejeon] (Chungnam National University), Lawrence University, Gastroenterology & Hepatology, Tata Research Development and Design Center (TRDDC), TCS Innovation Labs, University of Helsinki, Google Inc [Mountain View], Research at Google, Swedish Defense Research Agency (FOI), Servicio de Neurologia (SANTIAGO - Neurologie), Universidad del Desarrollo, Novartis Pharmaceutical Corporation, Laboratoire de glaciologie et géophysique de l'environnement (LGGE), Observatoire des Sciences de l'Univers de Grenoble [1985-2015] (OSUG [1985-2015]), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Department of Mechanical and Automation Engineering (CAD Laboratory), The Chinese University of Hong Kong [Hong Kong], Università degli studi di Bari, Department of Health and Human Services, National Institutes of Health [Bethesda] (NIH), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Heuristique et Diagnostic des Systèmes Complexes [Compiègne] (Heudiasyc), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), College of Information and Electrical Engineering [Beijing] (CIEE), China Agricultural University (CAU), Thales Research and Technology [Palaiseau], THALES, Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (QMUL), Centre d'économie de la Sorbonne (CES), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), École supérieure du professorat et de l'éducation - Académie de Grenoble [2013-2019] (ESPE Grenoble [2013-2019]), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Department of Mathematics, University of Iowa [Iowa City], College of Medicine, Alfaisal University, Saudi Ministry of Health, Institut national des recherches agricoles du Bénin, Centre de Recherches agricoles du Sud, Departments of Epidemiology and Nutrition, Unit of Human Nutrition, Agricultural University of Athens, Department of Animal Science, Pennsylvania State University (Penn State), Penn State System-Penn State System, University of Virginia, University of Virginia [Charlottesville], Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health - IRCCS ‘‘Burlo Garofolo', Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Division of Cardiovascular Medicine and Channing Division of Network Medicine, Brigham and Women's Hospital [Boston], American University of Beirut [Beyrouth] (AUB), Department of Chemistry, Scientific Computing Research Unit, Department of dermatology, Milano University-Azienda Ospedaleria Ospedali Riuniti di Bergamo, Mailman School of Public Health, Columbia University [New York], The Georges Institute for International Health, The University of Sydney, Department of epidemiology and Public Health, Faculty of Medicine, Département Optique (OPT), Université européenne de Bretagne - European University of Brittany (UEB)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT), Laboratoire des signaux et systèmes (L2S), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Universitat Pompeu Fabra [Barcelona], Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Nutriments Lipidiques et Prévention des Maladies Métaboliques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université de la Méditerranée - Aix-Marseille 2, Department of Neurology Lunds University Hospital Lund, Unit of Functional Bionanomaterials, School of Biosciences, University of Birmingham [Birmingham], Electrical Engineering and Computer Science Department - Case Western Reserve University, Case Western Reserve University [Cleveland], World Health Organization, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Nordic School of Public Health, The James Hutton Institute, Horia Hulubei National Institute for Physics and Nuclear Engineering, Department of Pediatrics, University of Washington [Seattle], Institute of Public Health, Department of Physics, Clarendon Laboratory, Center for TeleInFrastruktur (CTIF), Aalborg University [Denmark] (AAU), Physikalisches Institut [Freiburg], Albert-Ludwigs-Universität Freiburg, Savoirs, Textes, Langage (STL) - UMR 8163 (STL), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Dept.of Computer Science, Indian Institute of Technology Madras (IIT Madras), Istituto Mario Negri Bergamo, Centro Ricerche e Trapianti Villa Camozzi, Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut geològic de Catalunya (IGC), Institut Geològic de Catalunya-IGC, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Recherche Agronomique (INRA), Politecnico di Milano [Milan] (POLIMI), Symantec, University of Oviedo, European Microsoft Innovation Center (EMIC), Microsoft Corporation [Redmond, Wash.], Technion - Israel Institute of Technology [Haifa], Laboratoire de Mécanique, Physique et Géosciences (LMPG), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU), Department of Physics, Cavendish Laboratory, University of Cambridge [UK] (CAM), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Departments of Applied Physics [New Haven], Yale University [New Haven], Center for Mathematical Modeling (CMM), Department of Global Health and Development, London School of Hygiene and Tropical Medicine (LSHTM), University of Occupational and Environmental Health [Kitakyushu] (UEOH), Department of Computer Science and Engineering [New Delhi], Indian Institute of Technology Delhi (IIT Delhi), Institut de Recherche sur les Phénomènes Hors Equilibre (IRPHE), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), GlaxoSmithKline, Imperial College London-Clinical Imaging Center, Universidade Federal de Pernambuco [Recife] (UFPE), Maclean Building, Benson Lane, Crowmarsh Gifford, Centre for Ecology and Hydrology, Nanoscience Institute (NEST), Dipartimento di Fisica, Università di Pisa, Aristotle University of Thessaloniki, Laboratory Of Immune Cell Biology (LICB), JRC Institute for Environment and Sustainability (IES), European Commission - Joint Research Centre [Ispra] (JRC), Institute of Human Genetics, Rheinische Friedrich-Wilhelms-Universität Bonn, Laboratorio Nacional de Computação Cientifica [Rio de Janeiro] (LNCC / MCT), Occupational Health Unit, Bologna University Hospital-Sant'Orsola-Malpighi Polyclinic, Royal Institute of Technology [Stockholm] (KTH ), NICTA [Eveleigh], National ICT Australia [Sydney] (NICTA), Division of Solid Mechanics, Lund University [Lund], University of Calgary, BioWare Corp, Manchester Academic Health Sciences Centre, Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Ghent University [Belgium] (UGENT), Imaging Sciences and Biomedical Engineering Division [London], Guy's and St Thomas' Hospital [London]-King‘s College London, Children’s Hospital of Philadelphia (CHOP ), Perelman School of Medicine, University of Pennsylvania [Philadelphia], Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Génie Civil et Mécanique (GeM), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Department of Physiology, Augusta University - Medical College of Georgia, University System of Georgia (USG)-University System of Georgia (USG), Neurorestoration Group, Wolfson Centre for Age-related Diseases-King‘s College London, Electronic Navigation Research Institute (ENRI), Ministry of Land, Infrastructure, Transport and Tourism, Department of Computer Science [KAIST] (CS), Korea Advanced Institute of Science and Technology (KAIST), Centre for Undergraduate Studies, University of the Punjab, Siemens Corporate Research, Siemens AG [Munich], University of Massachusetts [Boston] (UMass Boston), University of Massachusetts System (UMASS), Department of Materials Science, Sichuan University [Chengdu] (SCU), Natl Engn Res Ctr Vegetables, Key Lab Biol & Genet Improvement Hort Crops N Chi, Beijing Acad Agr & Forestry Sci, University Hospital Puerta de Hierro, Madrid, Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University (PSL), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Shahid Beheshti University of Medical Sciences, École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), MOLTECH-ANJOU (MOLTECH-ANJOU), Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS), Universidad de Santiago de Chile [Santiago] (USACH)-Universidad del Desarrollo, Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), École supérieure du professorat et de l'éducation - Académie de Grenoble (ESPE Grenoble), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Grenoble Alpes (UGA), California Institute of Technology (CALTECH)-NASA, Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Sud - Paris 11 (UP11), Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universidad de Santiago de Chile [Santiago] (USACH), École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), King‘s College London-Wolfson Centre for Age-related Diseases, Sichuan University, Universitat de Barcelona, Interne Geneeskunde, Medische Sociologie, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Mines-Télécom [Paris] (IMT)-Télécom Bretagne-Université européenne de Bretagne - European University of Brittany (UEB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), RS: MHeNs - R2 - Mental Health, Laboratoire de Physique des Solides ( LPS ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de psychologie sociale et de psychologie cognitive ( LAPSCO ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Centre National de la Recherche Scientifique ( CNRS ), Erosion torrentielle neige et avalanches ( UR ETGR ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ), Hong Kong Baptist University ( HKBU ), Institut für Informatik [München/Munich] ( LMU ), Ludwig-Maximilians-Universität München, Neuroépidémiologie Tropicale ( NET ), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ), Insight Centre for Data Analytics (National University of Ireland Galway (NUIG)) ( INSIGHT ), Maladies chroniques, santé perçue, et processus d'adaptation ( APEMAC ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), University of Oslo ( UiO ) -University of Oslo ( UiO ), Centro de Estudios Avanzados en Zonas Aridas ( CEAZA ), Ecole Polytechnique Fédérale de Lausanne ( EPFL ), Laboratoire d'Ingénierie des Matériaux ( LIM ), Centre National de la Recherche Scientifique ( CNRS ), Lawrence Berkeley National Laboratory [Berkeley] ( LBNL ), Samsung Research &Development Institute India - Bangalore (Groupe Samsung) ( SRI-B ), Computational Science and Engineering Department [Daresbury] ( STFC ), Multimedia Research Center ( MRC ), University of Alberta [Edmonton], Division of Biostatistics ( Biostat - MINNEAPOLIS ), University of Minnesota [Minneapolis], University of Southampton [Southampton], Interactions, transferts, ruptures artistiques et culturels - EA 6301 ( InTRu ), Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), University Medical Center Utrecht, Biologie Fonctionnelle et Adaptative ( BFA ), Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, Unité de recherche Virologie et Immunologie Moléculaires ( VIM ), Institut National de la Recherche Agronomique ( INRA ), National University of Singapore ( NUS ), Centre de Robotique ( CAOR ), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University ( PSL ), Department of Signal Theory and Communications ( TSC ), RESPEC ( RESPEC ), Advanced Laboratories on Embedded Systems [Roma] ( ALES ), Wageningen University and Research Centre [Wageningen] ( WUR ), Universitat Politècnica de Catalunya [Barcelona] ( UPC ), Institut National de Recherche et d'Analyse Physico-Chimique ( INRAP ), Institut National de Recherche et d'Analyse Physico-chimique (INRAP-Tunisie), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) ( FEMTO-ST ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ), Tehran University, Sociétés, Acteurs, Gouvernement en Europe ( SAGE ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale ( SESSTIM - U912 INSERM - AMU - IRD ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Washington State University ( WSU ), Laboratoire de Physique de l'ENS Lyon ( Phys-ENS ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Institut des Sciences Chimiques de Rennes ( ISCR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Ecole Nationale Supérieure de Chimie de Rennes-Institut National des Sciences Appliquées ( INSA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en informatique de Toulouse ( IRIT ), Institut National Polytechnique [Toulouse] ( INP ) -Université Toulouse 1 Capitole ( UT1 ) -Université Toulouse - Jean Jaurès ( UT2J ) -Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche en Automatique de Nancy ( CRAN ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Université Catholique de Louvain ( UCL ), Freie Universität Berlin [Berlin], Div Cyclotron & Radiopharmaceut Sci ( DRDO, INMAS ), Institut de Physique Nucléaire d'Orsay ( IPNO ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Tata Research Development and Design Center ( TRDDC ), Laboratoire MOLTECH-Anjou [Angers] ( MOLTECH ANJOU ), Université d'Angers ( UA ) -Centre National de la Recherche Scientifique ( CNRS ), University of Helsinki [Helsinki], Swedish Defense Research Agency ( FOI ), Servicio de Neurologia ( SANTIAGO - Neurologie ), Universidad de Santiago de Chile [Santiago] ( USACH ) -Universidad del Desarrollo, Novartis Pharmaceutical Corp., East Hanover NJ 07936, USA, Laboratoire de glaciologie et géophysique de l'environnement ( LGGE ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Mechanical and Automation Engineering ( CAD Laboratory ), National Institutes of Health ( NIH ), Centre d'étude et de recherche en informatique et communications ( CEDRIC ), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise ( ENSIIE ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ), Heuristique et Diagnostic des Systèmes Complexes [Compiègne] ( Heudiasyc ), Université de Technologie de Compiègne ( UTC ) -Centre National de la Recherche Scientifique ( CNRS ), College of Information and Electrical Engineering [Beijing] ( CIEE ), China Agricultural University ( CAU ), Queen Mary University of London ( QMUL ), Centre d'économie de la Sorbonne ( CES ), Université Panthéon-Sorbonne ( UP1 ) -Centre National de la Recherche Scientifique ( CNRS ), Paris School of Economics ( PSE ), École supérieure du professorat et de l'éducation - Académie de Grenoble ( ESPE Grenoble ), Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Université Grenoble Alpes ( UGA ), PennState University [Pennsylvania] ( PSU ), Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), American University of Beirut [Beyrouth], The University of Sydney [Sydney], Département Optique ( OPT ), Université européenne de Bretagne ( UEB ) -Télécom Bretagne-Institut Mines-Télécom [Paris], Laboratoire des signaux et systèmes ( L2S ), Université Paris-Sud - Paris 11 ( UP11 ) -CentraleSupélec-Centre National de la Recherche Scientifique ( CNRS ), Center for Research in Environmental Epidemiology ( CREAL ), Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique ( INRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for TeleInFrastruktur ( CTIF ), Aalborg University [Denmark] ( AAU ), Savoirs, Textes, Langage (STL) - UMR 8163 ( STL ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Indian Institute of Technology Madras ( IIT Madras ), Universidade Estadual Paulista Júlio de Mesquita ( UNESP ), Laboratoire de Génie Informatique et Ingénierie de Production ( LGI2P ), IMT - Mines Alès Ecole Mines - Télécom ( IMT - MINES ALES ), Institut geològic de Catalunya ( IGC ), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physiologie et Génomique des Poissons ( LPGP ), Institut National de la Recherche Agronomique ( INRA ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Politecnico di Milano [Milan], European Microsoft Innovation Center ( EMIC ), Laboratoire de Mécanique, Physique et Géosciences ( LMPG ), Université Le Havre Normandie ( ULH ), Normandie Université ( NU ) -Normandie Université ( NU ), University of Cambridge [UK] ( CAM ), Laboratoire de Probabilités et Modèles Aléatoires ( LPMA ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Génétique et de Biologie Moléculaire et Cellulaire ( IGBMC ), Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Center for Mathematical Modeling ( CMM ), Universidad de Santiago de Chile [Santiago] ( USACH ), London School of Hygiene and Tropical Medicine ( LSHTM ), University of Occupational and Environmental Health [Kitakyushu] ( UEOH ), Indian Institute of Technology Delhi ( IIT Delhi ), Institut de Recherche sur les Phénomènes Hors Equilibre ( IRPHE ), Aix Marseille Université ( AMU ) -Ecole Centrale de Marseille ( ECM ) -Centre National de la Recherche Scientifique ( CNRS ), Universidade Federal de Pernambuco [Recife] ( UFPE ), Nanoscience Institute ( NEST ), Laboratory Of Immune Cell Biology ( LICB ), JRC Institute for Environment and Sustainability ( IES ), European Commission - Joint Research Centre [Ispra] ( JRC ), Bonn Universität [Bonn], Laboratorio Nacional de Computação Cientifica [Rio de Janeiro] ( LNCC / MCT ), Royal Institute of Technology [Stockholm] ( KTH ), National ICT Australia [Sydney] ( NICTA ), Institut d'Histoire et de Philosophie des Sciences et des Techniques ( IHPST ), Université Panthéon-Sorbonne ( UP1 ) -Département d'Etudes Cognitives - ENS Paris ( DEC ), École normale supérieure - Paris ( ENS Paris ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ), Ghent University [Belgium] ( UGENT ), Children’s Hospital of Philadelphia ( CHOP ), Univeristy of Pennsylvania Medical School, Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique ( LHEEA ), École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche en Génie Civil et Mécanique ( GeM ), Université de Nantes ( UN ) -École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Medical College of Georgia, Electronic Navigation Research Institute ( ENRI ), Department of Computer Science [KAIST] ( CS ), Korea Advanced Institute of Science and Technology ( KAIST ), Laboratoire de l'Accélérateur Linéaire ( LAL ), University of Massachusetts [Boston] ( UMass Boston ), Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H. Ro, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Kc, Astha, Kyu, Hmwe H, Moradi Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Ozgoren, Ayse Abbasoglu, Abd Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu Rmeileh, Niveen M. E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, Françoi, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Cunningham, Solveig Argeseanu, Arnlöv, Johan, Arsenijevic, Valentina S. Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charle, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker Collo, Suzanne L, Barquera, Simon, Barregard, Lar, Barrero, Lope H, Barrientos Gutierrez, Tonatiuh, Basto Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Ruvalcaba, Carolina Bati, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Bori, Abdulhak, Aref A. Bin, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Başara, Berrak Bora, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D. M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G. J, Campos Nonato, Ismael R, Campuzano, Julio C, Cantoral, Alejandra J, Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O, Caso, Valeria, Castañeda Orjuela, Carlos A, Castro, Ruben E, Catalá López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P, Chimed Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A, Chuang, Ting Wu, Chugh, Sumeet S, Cirillo, Massimo, Claßen, Thomas Kd, Colistro, Valentina, Colomar, Mercede, Colquhoun, Samantha M, Contreras, Alejandra G, Cooper, Cyru, Cooperrider, Kimberly, Cooper, Leslie T, Coresh, Josef, Courville, Karen J, Criqui, Michael H, Cuevas Nasu, Lucia, Damsere Derry, Jame, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Davis, Adrian, Davitoiu, Dragos V, Dayama, Anand, de Castro, E. Filipa, De la Cruz Góngora, Vanessa, De Leo, Diego, de Lima, Graça, Degenhardt, Louisa, Del Pozo Cruz, Borja, Dellavalle, Robert P, Deribe, Kebede, Derrett, Sarah, Jarlais, Don C. De, Dessalegn, Muluken, Deveber, Gabrielle A, Devries, Karen M, Dharmaratne, Samath D, Dherani, Mukesh K, Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E. Ray, Driscoll, Tim R, Duan, Leilei, Durrani, Adnan M, Ebel, Beth E, Ellenbogen, Richard G, Elshrek, Yousef M, Endres, Matthia, Ermakov, Sergey P, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Faraon, Emerito Jose A, Farzadfar, Farshad, Fay, Derek F. J, Feigin, Valery L, Feigl, Andrea B, Fereshtehnejad, Seyed Mohammad, Ferrari, Alize J, Ferri, Cleusa P, Flaxman, Abraham D, Fleming, Thomas D, Foigt, Nataliya, Foreman, Kyle J, Paleo, Urbano Fra, Franklin, Richard C, Gabbe, Belinda, Gaffikin, Lynne, Gakidou, Emmanuela, Gamkrelidze, Amiran, Gankpé, Fortuné G, Gansevoort, Ron T, García Guerra, Francisco A, Gasana, Evariste, Geleijnse, Johanna M, Gessner, Bradford D, Gething, Pete, Gibney, Katherine B, Gillum, Richard F, Ginawi, Ibrahim A. M, Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goginashvili, Ketevan, Dantes, Hector Gomez, Gona, Philimon, de Cosio, Teresita Gonzalez, González Castell, Dinorah, Gotay, Carolyn C, Goto, Atsushi, Gouda, Hebe N, Guerrant, Richard L, Gugnani, Harish C, Guillemin, Franci, Gunnell, David, Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A, Hafezi Nejad, Nima, Hagan, Holly, Hagstromer, Maria, Halasa, Yara A, Hamadeh, Randah R, Hammami, Mouhanad, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Haregu, Tilahun Nigatu, Haro, Josep Maria, Havmoeller, Rasmu, Hay, Simon I, Hedayati, Mohammad T, Heredia Pi, Ileana B, Hernandez, Lucia, Heuton, Kyle R, Heydarpour, Pouria, Hijar, Martha, Hoek, Hans W, Hoffman, Howard J, Hornberger, John C, Hosgood, H. Dean, Hoy, Damian G, Hsairi, Mohamed, Hu, Guoqing, Hu, Howard, Huang, Cheng, Huang, John J, Hubbell, Bryan J, Huiart, Laetitia, Husseini, Abdullatif, Iannarone, Marissa L, Iburg, Kim M, Idrisov, Bulat T, Ikeda, Nayu, Innos, Kaire, Inoue, Manami, Islami, Farhad, Ismayilova, Samaya, Jacobsen, Kathryn H, Jansen, Henrica A, Jarvis, Deborah L, Jassal, Simerjot K, Jauregui, Alejandra, Jayaraman, Sudha, Jeemon, Panniyammakal, Jensen, Paul N, Jha, Vivekanand, Jiang, Fan, Jiang, Guohong, Jiang, Ying, Jonas, Jost B, Juel, Knud, Kan, Haidong, Roseline, Sidibe S. Kany, Karam, Nadim E, Karch, André, Karema, Corine K, Karthikeyan, Ganesan, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S, Kemp, Andrew H, Kengne, Andre P, Keren, Andre, Khader, Yousef S, Khalifa, Shams Eldin Ali Hassan, Khan, Ejaz A, Khang, Young Ho, Khatibzadeh, Shahab, Khonelidze, Irma, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kimokoti, Ruth W, Kinfu, Yohanne, Kinge, Jonas M, Kissela, Brett M, Kivipelto, Miia, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kose, M. Rifat, Kosen, Soewarta, Kraemer, Alexander, Kravchenko, Michael, Krishnaswami, Sanjay, Kromhout, Han, Ku, Tiffany, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kuipers, Ernst J, Kulkarni, Chanda, Kulkarni, Veena S, Kumar, G. Anil, Kwan, Gene F, Lai, Taavi, Balaji, Arjun Lakshmana, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C, Larson, Heidi J, Larsson, Ander, Laryea, Dennis O, Lavados, Pablo M, Lawrynowicz, Alicia E, Leasher, Janet L, Lee, Jong Tae, Leigh, Jame, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liang, Xiaofeng, Lim, Stephen S, Lindsay, M. Patrice, Lipshultz, Steven E, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Logroscino, Giancarlo, London, Stephanie J, Lopez, Nancy, Lortet Tieulent, Joannie, Lotufo, Paulo A, Lozano, Rafael, Lunevicius, Raimunda, Ma, Jixiang, Ma, Stefan, Machado, Vasco M. P, Macintyre, Michael F, Magis Rodriguez, Carlo, Mahdi, Abbas A, Majdan, Marek, Malekzadeh, Reza, Mangalam, Srikanth, Mapoma, Christopher C, Marape, Marape, Marcenes, Wagner, Margolis, David J, Margono, Christopher, Marks, Guy B, Martin, Randall V, Marzan, Melvin B, Mashal, Mohammad T, Masiye, Felix, Mason Jones, Amanda J, Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M, Mazorodze, Tasara T, Mckay, Abigail C, Mckee, Martin, Mclain, Abigail, Meaney, Peter A, Medina, Catalina, Mehndiratta, Man Mohan, Mejia Rodriguez, Fabiola, Mekonnen, Wubegzier, Melaku, Yohannes A, Meltzer, Michele, Memish, Ziad A, Mendoza, Walter, Mensah, George A, Meretoja, Atte, Mhimbira, Francis Apolinary, Micha, Renata, Miller, Ted R, Mills, Edward J, Misganaw, Awoke, Mishra, Santosh, Ibrahim, Norlinah Mohamed, Mohammad, Karzan A, Mokdad, Ali H, Mola, Glen L, Monasta, Lorenzo, Hernandez, Julio C. Montañez, Montico, Marcella, Moore, Ami R, Morawska, Lidia, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N, Mozaffarian, Dariush, Mueller, Ulrich O, Mukaigawara, Mitsuru, Mullany, Erin C, Murthy, Kinnari S, Naghavi, Mohsen, Nahas, Ziad, Naheed, Aliya, Naidoo, Kovin S, Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, Km Venkat, Nash, Deni, Neal, Bruce, Nejjari, Chakib, Neupane, Sudan P, Newton, Charles R, Ngalesoni, Frida N, de Dieu Ngirabega, Jean, Nguyen, Grant, Nguyen, Nhung T, Nieuwenhuijsen, Mark J, Nisar, Muhammad I, Nogueira, José R, Nolla, Joan M, Nolte, Sandra, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nyakarahuka, Luke, Oh, In Hwan, Ohkubo, Takayoshi, Olusanya, Bolajoko O, Omer, Saad B, Opio, John Nelson, Orozco, Ricardo, Pagcatipunan, Rodolfo S, Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Papachristou, Christina, Park, Eun Kee, Parry, Charles D, Caicedo, Angel J. Paternina, Patten, Scott B, Paul, Vinod K, Pavlin, Boris I, Pearce, Neil, Pedraza, Lilia S, Pedroza, Andrea, Stokic, Ljiljana Pejin, Pekericli, Ayfer, Pereira, David M, Perez Padilla, Rogelio, Perez Ruiz, Fernando, Perico, Norberto, Perry, Samuel A. L, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B, Petzold, Max, Phillips, Michael R, Phua, Hwee Pin, Plass, Dietrich, Poenaru, Dan, Polanczyk, Guilherme V, Polinder, Suzanne, Pond, Constance D, Pope, C. Arden, Pope, Daniel, Popova, Svetlana, Pourmalek, Farshad, Powles, John, Prabhakaran, Dorairaj, Prasad, Noela M, Qato, Dima M, Quezada, Amado D, Quistberg, D. Alex A, Racapé, Lionel, Rafay, Anwar, Rahimi, Kazem, Rahimi Movaghar, Vafa, Rahman, Sajjad Ur, Raju, Murugesan, Rakovac, Ivo, Rana, Saleem M, Rao, Mayuree, Razavi, Homie, Reddy, K. Srinath, Refaat, Amany H, Rehm, Jürgen, Remuzzi, Giuseppe, Ribeiro, Antonio L, Riccio, Patricia M, Richardson, Lee, Riederer, Anne, Robinson, Margaret, Roca, Anna, Rodriguez, Alina, Rojas Rueda, David, Romieu, Isabelle, Ronfani, Luca, Room, Robin, Roy, Nobhojit, Ruhago, George M, Rushton, Lesley, Sabin, Nsanzimana, Sacco, Ralph L, Saha, Sukanta, Sahathevan, Ramesh, Sahraian, Mohammad Ali, Salomon, Joshua A, Salvo, Deborah, Sampson, Uchechukwu K, Sanabria, Juan R, Sanchez, Luz Maria, Sánchez Pimienta, Tania G, Sanchez Riera, Lidia, Sandar, Logan, Santos, Itamar S, Sapkota, Amir, Satpathy, Maheswar, Saunders, James E, Sawhney, Monika, Saylan, Mete I, Scarborough, Peter, Schmidt, Jürgen C, Schneider, Ione J. C, Schöttker, Ben, Schwebel, David C, Scott, James G, Seedat, Soraya, Sepanlou, Sadaf G, Serdar, Berrin, Servan Mori, Edson E, Shaddick, Gavin, Shahraz, Saeid, Levy, Teresa Shamah, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shibuya, Kenji, Shin, Hwashin H, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Gitanjali M, Singh, Jasvinder A, Skirbekk, Vegard, Sliwa, Karen, Soljak, Michael, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stapelberg, Nicolas J. 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Alex A., Rahimi-Movaghar, Vafa, Ur Rahman, Sajjad, Rana, Saleem M., Refaat, Amany H., Ribeiro, Antonio L., Riccio, Patricia M., Rojas-Rueda, David, Ruhago, George M., Sacco, Ralph L., Salomon, Joshua A., Sampson, Uchechukwu K., Sanabria, Juan R., Sánchez-Pimienta, Tania G., Sanchez-Riera, Lidia, Santos, Itamar S., Saunders, James E., Saylan, Mete I., Schmidt, Jürgen C., Schneider, Ione J.C., Schwebel, David C., Scott, James G., Sepanlou, Sadaf G., Servan-Mori, Edson E., Shamah Levy, Teresa, Shin, Hwashin H., Sigfusdottir, Inga D., Silberberg, Donald H., Simard, Edgar P., Singh, Gitanjali M., Singh, Jasvinder A., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stapelberg, Nicolas J.C., Stein, Dan J., Stein, Murray B., Sunguya, Bruno F., Sykes, Bryan L., Tabb, Karen M., Talongwa, Roberto T., Te Ao, Braden J., Teixeira, Carolina M., Téllez Rojo, Martha M., Terkawi, Abdullah S., Texcalac-Sangrador, José Lui, Thackway, Sarah V., Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Towbin, Jeffrey A., Tran, Bach X., Tsala Dimbuene, Zacharie, Uchendu, Uche S., Ukwaja, Kingsley N., Uzun, Selen B., Van De Vijver, Steven, Van Gool, Coen H., Van Os, Jim, Varakin, Yuri Y., Vasankari, Tommi J., Vasconcelos, Ana Maria N., Vavilala, Monica S., Veerman, Lennert J., Velasquez-Melendez, Gustavo, Venketasubramanian, N., Violante, Francesco S., Victorovich Vlassov, Vasiliy, Wagner, Gregory R., Waller, Stephen G., Wallin, Mitchell T., Warouw, Tati S., Watts, Charlotte H., Weintraub, Robert G., Whiteford, Harvey A., Wilkinson, James D., Williams, Hywel C., Williams, Thomas N., Woldeyohannes, Solomon M., Wolfe, Charles D.A., Wong, John Q., Woolf, Anthony D., Wright, Jonathan L., Yan, Lijing L., Yentür, Gökalp K., Yoon, Seok-Jun, Younis, Mustafa Z., Zaki, Maysaa E., Zunt, Joseph R., Lopez, Alan D., and Temesgen, A.M.
Subjects: Male, Fine particulate matter, Nutrition and Disease, MESH : Sanitation, Health Behavior, Diseases, MESH: Metabolic Diseases, MESH: Global Health, 030204 cardiovascular system & hematology, MESH: Risk Assessment, Global Health, MESH : Nutritional Status, MESH: Occupational Exposure, 0302 clinical medicine, Unsafe Sex, MESH: Risk Factors, Risk Factors, Voeding en Ziekte, Medicine, Air-pollution, MESH : Female, 030212 general & internal medicine, MESH : Risk Assessment, Sanitation, Wasting, 2. Zero hunger, Factors de risc en les malalties, Medicine (all), [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, MESH : Occupational Diseases, MESH: Nutritional Status, All-cause mortality, MESH : Risk Factors, humanities, Environmental Exposure, Female, Humans, Metabolic Diseases, Nutritional Status, Occupational Diseases, Occupational Exposure, Risk Assessment, Tobacco smoking, 3. Good health, Nutritional Statu, MESH : Occupational Exposure, MESH : Metabolic Diseases, Cohort, medicine.symptom, Risk assessment, Blood-pressure, Human, MESH: Occupational Diseases, Risk factors in diseases, Coronary-heart-disease, MESH : Male, MESH: Health Behavior, MESH: Environmental Exposure, Population health, Body-mass index, 03 medical and health sciences, Household cooking, Cardiovascular-disease, Environmental health, General & Internal Medicine, parasitic diseases, Life Science, MESH: Sanitation, Risk factor, MESH : Health Behavior, VLAG, GBD2013, MESH: Humans, business.industry, Risk Factor, Global Burden of Disease Study, 79 behavioural, environmental and occupational, and metabolic risks, Long-term exposure, MESH : Humans, CAUSE-SPECIFIC MORTALITY, MESH: Male, Metabolic Disease, Occupational Disease, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, MALE BRITISH DOCTORS, Years of potential life lost, Relative risk, Malalties, MESH : Global Health, OUTDOOR AIR-POLLUTION, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH : Environmental Exposure, MESH: Female
Abstract: Summary Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5−89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. Funding Bill & Melinda Gates Foundation. Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the fi rst of a series of annual updates of the GBD. Risk factor quantifi cation, particularly of modifi able risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the fi rst level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular fi ltration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5−89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. Funding Bill & Melinda Gates Foundation.
Published: 2015

50. Multiresolution analysis as a criterion for effective dynamic mesh adaptation – A case study for Euler equations in the SAMR framework AMROC

Author: Margarete Oliveira Domingues, Ralf Deiterding, Kai Schneider, University of Southampton, Southampton, University of Southampton, Instituto Nacional de Pesquisas Espaciais (INPE), Institut de Mathématiques de Marseille (I2M), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)
Subjects: [PHYS.PHYS.PHYS-FLU-DYN]Physics [physics]/Physics [physics]/Fluid Dynamics [physics.flu-dyn], General Computer Science, Computer science, Multiresolution analysis, adaptation criteria, wavelets, 01 natural sciences, Projection (linear algebra), multiresolution analysis, compressible Euler equations, 010305 fluids & plasmas, symbols.namesake, Wavelet, 0103 physical sciences, Applied mathematics, Block-structured parallel adaptive mesh refinement, 0101 mathematics, Finite volume method, Adaptive mesh refinement, General Engineering, Wavelet transform, Euler equations, 010101 applied mathematics, Nonlinear system, AMROC, symbols, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: International audience; Dynamic mesh adaptation methods require suitable refinement indicators. In the absence of a comprehensive error estimation theory, adaptive mesh refinement (AMR) for nonlinear hyperbolic conservation laws, e.g. com-pressible Euler equations, in practice utilizes mainly heuristic smoothness indicators like combinations of scaled gradient criteria. As an alternative, we describe in detail an easy to implement and computationally inexpensive criterion built on a two-level wavelet transform that applies projection and prediction operators from multiresolution analysis. The core idea is the use of the amplitude of the wavelet coefficients as smoothness indicator, as it can be related to the local regularity of the solution. Implemented within the fully parallelized and structured adaptive mesh refinement (SAMR) software system AMROC (Adaptive Mesh Refinement in Object-oriented C++), the proposed criterion is tested and comprehensively compared to results obtained by applying the scaled gradient approach. A rigorous quantification technique in terms of numerical adaptation error versus used finite volume cells is developed and applied to study typical two-and three-dimensional problems from compressible gas dynamics. It is found that the proposed multiresolution approach is considerably more efficient and also identifies-besides discontinuous shock and contact waves-in particular smooth rar-efaction waves and their interaction as well as small-scale disturbances much more reliably. Aside from pathological cases consisting solely of planar shock waves, the majority of realistic cases show reductions in the number of used finite volume cells between 20 to 40%, while the numerical error remains basically unaltered.
Published: 2020

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