1. Thyroid-stimulating hormone receptor antibody assays: recommendation for correct interpretation of results in Graves disease
- Author
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Catherine Massart, Michèle d’Herbomez, Unité Laboratoire CIC, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle biologie, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes]-CHU Pontchaillou [Rennes], Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle biologie, and Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes]-CHU Pontchaillou [Rennes]
- Subjects
endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Graves' disease ,Clinical Biochemistry ,030209 endocrinology & metabolism ,Trab ,MESH: Graves Disease ,Gastroenterology ,Thyrotropin receptor ,MESH: Calibration ,MESH: Receptors, Thyrotropin ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,MESH: Practice Guidelines as Topic ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal medicine ,medicine ,Humans ,ComputingMilieux_MISCELLANEOUS ,Immunoassay ,MESH: Humans ,biology ,business.industry ,Biochemistry (medical) ,Thyroid ,Receptors, Thyrotropin ,Reference Standards ,medicine.disease ,Graves Disease ,3. Good health ,medicine.anatomical_structure ,Hormone receptor ,Calibration ,Practice Guidelines as Topic ,Immunology ,030221 ophthalmology & optometry ,biology.protein ,Etiology ,MESH: Reference Standards ,Antibody ,business ,MESH: Immunoassay ,MESH: Immunoglobulins, Thyroid-Stimulating ,Immunoglobulins, Thyroid-Stimulating - Abstract
To the Editor: In Graves disease, the clinical uses of thyrotropin receptor [thyroid-stimulating hormone receptor (TSH-R)1] antibody (TRAb) measurements have been reported in the Thyroid Guidelines of the American Thyroid Association (1). First, TRAb measurements are used to investigate the etiology of hyperthyroidism when the diagnosis is not clinically obvious; second, a declining TRAb concentration during long-term antithyroid drug therapy is suggestive of remission, although TRAb measurements can be misleading in 25% of such patients; third, TRAb is used in the follow-up of pregnant women with a history or recent onset of Graves …
- Published
- 2013