68 results on '"Trovas G"'
Search Results
2. Progression of Rebound-Associated Vertebral Fractures Following Denosumab Discontinuation Despite Reinstitution of Treatment: Suppressing Increased Bone Turnover May Not Be Enough
- Author
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Anastasilakis, A.D. Trovas, G. Balanika, A. Polyzos, S.A. Makras, P. Tournis, S.
- Abstract
Rebound-associated vertebral fractures (RAVFs) could occur in a minority of the patients who discontinue denosumab. In such patients, denosumab is often reinstituted to rapidly suppress bone turnover and avert the risk of additional fractures. Herein we report the cases of 2 patients who sustained RAVFs, and in whom resuming denosumab treatment did not avert the occurrence of new RAVFs a few months later, despite the suppression of bone turnover markers. It seems that denosumab reinstitution cannot completely eliminate the risk of new RAVFs and that the rebound of bone turnover may not be the sole mechanism to explain this phenomenon. © 2020 The International Society for Clinical Densitometry
- Published
- 2021
3. Vitamin D and COVID-19
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Trovas, G. Tournis, S.
- Abstract
Epidemiological data report that several countries with a high prevalence of hypovitaminosis D may have increased susceptibility to complications and mortality due to COVID-19 infection. These reports, however, have limitations given that they derive from observational studies. Nevertheless, while awaiting more robust data, clinicians should treat patients with vitamin D deficiency irrespective of whether or not it has a link with respiratory infections. © 2020, Hellenic Endocrine Society.
- Published
- 2021
4. Dietary patterns of greek adults and their associations with serum vitamin d levels and heel quantitative ultrasound parameters for bone health
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Grigoriou, E. Trovas, G. Papaioannou, N. Dontas, I. Makris, K. Apostolou-Karampelis, K. Dedoussis, G.
- Abstract
The aim of this study is to investigate the dietary patterns which indicate the nutritional habits of Greek adults and their effects on serum 25(OH)D levels and quantitative ultrasound (QUS) parameters for bone health. This study is part of OSTEOS, an observational cross-sectional study. In total, 741 adults from rural and urban areas throughout Greece were recruited. A validated food frequency questionnaire (FFQ) was used for assessment of the population’s dietary habits. Serum 25(OH)D was measured by enzyme immunoassay; QUS parameters were assessed with an Achilles device. Principal component analysis (PCA) was carried out for dietary pattern determination, and univariate analysis of variance was used for the assessment of 25(OH)D, broadband ultrasound attenuation (BUA), speed of sound (SOS), and stiffness index (SI) determinants. Six dietary patterns explain 52.2% of the variability of Greek adults’ nutritional habits. The ‘vegetables–fruit’ dietary pattern explains the biggest rate of variability. Determinants of serum 25(OH)D are body mass index (BMI), elderly status, summer sun exposure, organized physical activity, a ‘healthy’ pattern in winter months, and adherence to a ‘sweet’ pattern. Determinants of QUS parameters are age, BMI, sedentary time, organized physical activity participation, and adherence to a ‘healthy’ pattern. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Published
- 2020
5. Cardiovascular risk in patients with primary hyperparathyroidism
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Tournis, S. Makris, K. Cavalier, E. Trovas, G.
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endocrine system diseases - Abstract
Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders characterized by parathyroid hormone (PTH)-dependent hypercalcemia. Cardinal features include low trauma fractures, nephrolithiasis, and chronic kidney disease. Several experimental studies established that parathyroid hormone exerts actions on the cardiovascular (CV) system, including vasodilatation and positive inotropic and chronotropic effects. Observational studies, especially in severe cases, report a higher prevalence of hypertension, diabetes mellitus, lipid abnormalities, endothelial dysfunction, arrhythmias, and left ventricular hypertrophy in patients with PHPT, while the risk of CV events seems to be increased in severe cases. However, the effect of surgery is inconsistent on CV abnormalities and, more importantly, on CV disease (CVD) events, especially in mild cases. In the current review, we describe the available evidence linking PHPT and CVD, as well as the effect of surgical management and pharmacological treatment on CVD manifestations in patients with PHPT. Based on the current evidence, CVD is not considered an indication for surgery. © 2020 Bentham Science Publishers.
- Published
- 2020
6. The 2018 Guidelines for the diagnosis and treatment of osteoporosis in Greece
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Makras, P. Anastasilakis, A.D. Antypas, G. Chronopoulos, E. Kaskani, E.G. Matsouka, A. Patrikos, D.K. Stathopoulos, K.D. Tournis, S. Trovas, G. Kosmidis, C.
- Abstract
Summary: We report the updated guidelines for the management of osteoporosis in Greece, which include guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information, and national evidence from Greek clinical practice and the healthcare setting. Purpose: The purpose of this report was to update the Guidelines for the Management of Osteoporosis in Greece that was published in 2011. Methods: In line with the GRADE system, the working group initially defined the main clinical questions that should be addressed when dealing with the diagnosis and management of osteoporosis in clinical practice in Greece. Following a literature review and discussion on the experience gained from the implementation of the 2011 Guidelines transmitted through the national electronic prescription network, the Hellenic Society for the Study of Bone Metabolism (HSSBM) uploaded an initial draft for an open dialogue with the relevant registered medical societies and associations on the electronic platform of the Greek Ministry of Health. After revisions, the Central Health Council approved the final document. Results: The 2018 Guidelines provide comprehensive recommendations on the issues of the timing of fracture risk evaluation and dual-energy X-ray absorptiometry (DXA) measurement, interpretation of the DXA results, the diagnostic work-up for osteoporosis, the timing as well as the suggested medications for osteoporosis treatment, and the follow-up methodology employed during osteoporosis treatment. Conclusions: These updated guidelines were designed to offer valid guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information and national evidence from clinical practice and the healthcare setting. Clinical judgment is essential in the management of every individual patient for the purpose of achieving the optimal outcome in the safest possible way. © 2019, International Osteoporosis Foundation and National Osteoporosis Foundation.
- Published
- 2019
7. Letter to the editor: 'evaluation of bone mineral density using DXA and cQCT in postmenopausal patients under thyrotropin suppressive therapy'
- Author
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Tournis, S. Trovas, G. Triantafyllopoulos, I.K. Balanika, A.P.
- Published
- 2019
8. Hypercalcitoninaemia in pseudohypoparathyroidism type 1A and type 1B
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Yavropoulou, M.P. Chronopoulos, E. Trovas, G. Avramidis, E. Elli, F.M. Mantovani, G. Zebekakis, P. Yovos, J.G.
- Subjects
musculoskeletal diseases - Abstract
Pseudohypoparathyroidism (PHP) is a heterogeneous group of rare endocrine disorders characterised by normal renal function and renal resistance to the action of the parathyroid hormone. Type 1A (PHP1A), which is the most common variant, also include developmental and skeletal defects named as Albright hereditary osteodystrophy (AHO). We present two cases, a 54- and a 33-year-old male diagnosed with PHP who were referred to us for persistently high levels of serum calcitonin. AHO and multinodular goitre were present in the 54-year-old male, while the second patient was free of skeletal deformities and his thyroid gland was of normal size and without nodular appearance. We performed GNAS molecular analysis (methylation status and copy number analysis by MS-MLPA) in genomic DNA samples for both patients. The analysis revealed a novel missense variant c.131T>G p.(Leu44Pro) affecting GNAS exon 1, in the patient with the clinical diagnosis of PHP1A. This amino acid change appears to be in accordance with the clinical diagnosis of the patient. The genomic DNA analysis of the second patient revealed the presence of the recurrent 3-kb deletion affecting the imprinting control region localised in the STX16 region associated with the loss of methylation (LOM) at the GNAS A/B differentially methylated region and consistent with the diagnosis of an autosomal dominant form of PHP type 1B (PHP1B). In conclusion, hypercalcitoninaemia may be encountered in PHP1A and PHP1B even in the absence of thyroid pathology. © 2019 The authors.
- Published
- 2019
9. Serum 25-hydroxyvitamin D status, quantitative ultrasound parameters, and their determinants in Greek population
- Author
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Grigoriou, E.V. Trovas, G. Papaioannou, N. Makras, P. Kokkoris, P. Dontas, I. Makris, K. Tournis, S. Dedoussis, G.V.
- Abstract
Summary: Vitamin D deficiency and quantitative ultrasound measurements are associated with bone fragility. We assessed these parameters and their correlates. 87.7% of the population has vitamin D inadequacy and this correlated with lifestyle factors. These results contribute to epidemiological data needed for population guidelines for bone health. Purpose: Vitamin D deficiency and quantitative ultrasound (QUS) parameters are among the most important clinical risk factors of bone fragility. Few data are available for Greek population. The aim of the study was to evaluate the serum 25-hydroxyvitamin D [25(OH)D] level and their determinants, as well as QUS parameters in Greek population. Methods: OSTEOS is an observational cross-sectional study conducted from June 2010 to July 2012. Nine hundred seventy adults were recruited from rural and urban areas throughout Greece and completed the appropriate questionnaire. Serum 25(OH)D measured by enzyme immunoassay, QUS parameters, broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (SI), was assessed with an Achilles device. Univariate Analysis of Variance was used for the assessment of serum 25(OH)D determinants. Results: Mean serum 25(OH)D of the total population was 20,00 ± 8,00 ng/mL. Females had lower levels than males. The negative determinants of serum 25(OH)D in the total population were the female sex and the winter-spring season of sampling while age proved negative association solely in obese subjects. Positive determinants of vitamin D status were summer sun exposure and organized physical activity as expected. Urban had lower SOS and SI than rural residents. Individuals with 25(OH)D ≥ 20 ng/mL had higher SOS than those with 25(OH)D < 20 ng/mL. BUA, SOS, and SI are positively correlated with organized physical activity and negatively with PTH. Conclusions: This study reports that vitamin D deficiency is highly prevalent among healthy Greek men and women, demonstrates the multifactorial causation of 25(OH)D levels, and points out that further research is required to determine more factors related to vitamin D status and bone health. © 2018, International Osteoporosis Foundation and National Osteoporosis Foundation.
- Published
- 2018
10. Effect of calcitriol on FGF23 level in healthy adults and its dependence on phosphate level
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Georgiadou, E. Marketou, H. Trovas, G. Dontas, I. Papaioannou, N. Makris, K. Galanos, A. Papavassiliou, A.G.
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polycyclic compounds ,lipids (amino acids, peptides, and proteins) - Abstract
Aim: To evaluate the short-Term effects of calcitriol and sevelamer hydrochloride on fibroblast growth factor-23 (FGF23) in humans and to determine whether the effect is direct or indirect through calcitriol-induced increased absorption of phosphorus from the intestine. Patients and Methods: A total of 15 healthy individuals were tested at three time points and stages, for 24 h and at 1-week intervals. During each stage, blood samples were taken at three time points (0, 8 and 24 h); baseline stage: under no intervention; second stage, while receiving 0.5 μg calcitriol orally twice daily; and at the third stage, while receiving 0.5 μg calcitriol orally twice daily and sevelamer hydrochloride during meals. The changes in FGF23, parathyroid hormone, calcitriol, Ca, and phosphorus were determined. Results: During calcitriol administration, the FGF23 level changed significantly (p=0.008), with the level at 24 h levels being significantly higher than at 8 h (8.8 pg/ml vs. 13.0 pg/ml, p=0.036). There was a statistically significant difference in the percentage change, among the three stages, at time 8 to 24 h and 0 to 24 h for FGF23 (p=0.014 and p=0.015, respectively), with significant differences between baseline vs. calcitriol for 8 to 24 h FGF23 change (-9.23% vs. 26.98%, p=0.003) and a trend between baseline vs. calcitriol (p=0.061) and calcitriol plus sevelamer (p=0.069) for 0 to 24 h FGF23 change.
- Published
- 2017
11. Sarcopenia: From definition to treatment
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Dionyssiotis, Y. Kapsokoulou, A. Samlidi, E. Angoules, A.G. Papathanasiou, J. Chronopoulos, E. Kostoglou-Athanassiou, I. Trovas, G.
- Published
- 2017
12. Response to: A role for thiazide diuretic therapy in preventing bone loss, fracture and nephrolithiasis in individuals with thalassemia and hypercalciuria?
- Author
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Dede, A.D. Trovas, G. Chronopoulos, E. Triantafyllopoulos, I.K. Dontas, I. Papaioannou, N. Tournis, S.
- Published
- 2017
13. Thalassemia-associated osteoporosis: a systematic review on treatment and brief overview of the disease
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Dede, A.D. Trovas, G. Chronopoulos, E. Triantafyllopoulos, I.K. Dontas, I. Papaioannou, N. Tournis, S.
- Abstract
Summary: Thalassemia-associated osteoporosis constitutes a major complication in patients with thalassemia. This review presents the existing studies on the treatment of thalassemia-associated osteoporosis and discusses the management of this debilitating complication. A brief presentation of the disease characteristics and pathogenetic mechanisms is also provided. The life expectancy of patients with thalassemia has increased markedly in recent years resulting in the aging of the population and the emergence of new comorbidities. The majority of patients with thalassemia have low bone mineral density and experience lifelong fracture rates as high as 71 %. The pathogenesis of thalassemia-associated osteoporosis (TAO) is multifactorial with anemia and iron overload playing crucial role in its development. Data concerning the prevention and treatment of TAO are extremely limited. We performed a literature research in Pubmed and Scopus to identify interventional studies evaluating the effects of various agents on TAO. Seventeen studies were retrieved. We present the results of these studies as well as a brief overview of TAO including presentation, pathogenesis, and management. Most of the studies identified are of poor quality, are not randomized controlled, and include small number of participants. There are no data concerning effects on fracture rates. Bisphosphonates are the most widely studied agents and among them zoledronic acid is the most well studied. Hormone replacement treatment (HRT) shows beneficial but small effects. Denosumab and strontium ranelate have each been evaluated in only a single study, while there are no data about the effects of anabolic agents. Given the increased life expectancy and the increase in fracture rates with age, more data about the management of TAO are warranted. Moreover, due to the need for lifelong management starting at young age, careful treatment plans which may include sequential treatment may often be required. However, currently, there are no relevant data available. © 2016, International Osteoporosis Foundation and National Osteoporosis Foundation.
- Published
- 2016
14. Prospective study of spinal orthoses in women
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Dionyssiotis, Y. Trovas, G. Thoma, S. Lyritis, G. Papaioannou, N.
- Abstract
Background: There are not many clinical trials investigating the efficiency and compliance of using spinal orthoses in the management of osteoporosis. Objectives: The purpose of this study was to investigate the effect of long-term use and the compliance of spinal orthoses in postmenopausal women with vertebral fractures. Study design: Clinical trial of spinal orthoses in postmenopausal women. Methods: Women were separated into groups wearing different types of orthoses (Spinomed, Osteomed, Spinomed active, and Spine-X). Isometric maximum strength of trunk muscles (F/Wabdominals-extensors) was calculated and back pain was assessed in all women. In addition, women completed a compliance questionnaire about the use of the orthoses. Results: Spinomed decreased pain (p = 0.001) and increased trunk muscle strength (F/Wabdominals, p = 0.005 and F/Wextensors, p = 0.003, respectively). The compliance of wearing an orthosis for 6 months was 66%. Conclusion: The results suggest that orthoses could be an effective intervention for back pain and muscle strengthening in osteoporotic women. Clinical relevance In women with established osteoporosis, wearing Spinomed orthosis for at least 2 h/day for 6 months decreased back pain significantly and increased personal isometric trunk muscle strength. All spinal orthoses could be valuable instruments to help all requested rehabilitation programs like spine muscles' strengthening and postural correct behavior, but only when used properly. © 2014 The International Society for Prosthetics and Orthotics.
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- 2015
15. A review on osteoporosis in men
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Stathopoulos, I.P. Ballas, E.G. Lampropoulou-Adamidou, K. Trovas, G.
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- 2014
16. Type 2 diabetes mellitus and fracture risk
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Dede, A.D. Tournis, S. Dontas, I. Trovas, G.
- Abstract
Increased fracture risk, traditionally associated with type 1 diabetes, has lately been of great concern in patients with type 2 diabetes. A variable increase in fracture risk has been reported, ranging from 20% to 3-fold, depending on skeletal site, diabetes duration and study design. Longer disease duration, the presence of diabetic complications, inadequate glycemic control, insulin use and increased risk for falls are all reported to increase fracture risk. Patients with type 2 diabetes display a unique skeletal phenotype with either normal or more frequently increased, bone mineral density and impaired structural and geometric properties. Recently, alterations in bone material properties seem to be the predominant defect leading to increased bone fragility. Accumulation of advanced glycation end-products and changes in collagen cross-linking along with suppression of bone turnover seem to be significant factors impairing bone strength. FRAX score has been reported to underestimate fracture risk and lumbar spine BMD is inadequate in predicting vertebral fractures. Anti-diabetic medications, apart from thiazolidinediones, appear to be safe for the skeleton, although more data are needed. Optimal strategies to reduce skeletal fragility in type 2 diabetic patients are yet to be determined. © 2014 Elsevier Inc. All rights reserved.
- Published
- 2014
17. Effect of parathyroidectomy versus risedronate on volumetric bone mineral density and bone geometry at the tibia in postmenopausal women with primary hyperparathyroidism
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Tournis, S. Fakidari, E. Dontas, I. Liakou, C. Antoniou, J. Galanos, A. Marketou, H. Makris, K. Katsalira, K. Trovas, G. Lyritis, G.P. Papaioannou, N.
- Subjects
musculoskeletal diseases ,musculoskeletal system - Abstract
The objective of the study was to evaluate the effect of parathyroidectomy (PTX) versus 35 mg once-weekly (ow) risedronate administration on volumetric bone mineral density (vBMD) and bone geometry at the tibia in postmenopausal women with primary hyperparathyroidism (PHPT). Our open-label prospective observational study included 32 postmenopausal women with PHPT as the study group: 16 underwent PTX and 16 were treated with 35 mg ow risedronate for 2 years. We assessed areal BMD (aBMD) by DXA, and vBMD and bone mineral content (BMC) (cortical and trabecular area) by peripheral quantitative computed tomography (pQCT) at the tibia at baseline and at 2 years. Risedronate did not result in any significant change on vBMD and structural pQCT indices. PTX resulted in significant increase in trabecular (trab) BMC (6.44 %) and vBMD (4.64 %), with percent increase being significantly higher than risedronate (p < 0.05). At cortical sites, there was no significant change following PTX. However, the percent change in cortical (cort) vBMD was higher following PTX versus risedronate (0.39 % vs. -0.26 %, p < 0.05). In conclusion, in postmenopausal women with PHPT, PTX is superior to ow risedronate, in terms of improvement of trabecular mineralization and vBMD at the tibia, whereas the effect at cortical sites is less pronounced. © 2013 The Japanese Society for Bone and Mineral Research and Springer.
- Published
- 2014
18. Severe osteoporosis and mutation in NOTCH2 gene in a woman with Hajdu-Cheney syndrome
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Stathopoulos, I.P. Trovas, G. Lampropoulou-Adamidou, K. Koromila, T. Kollia, P. Papaioannou, N.A. Lyritis, G.
- Abstract
Hajdu-Cheney syndrome (HCS) is a rare genetic disorder characterised by acro-osteolysis, skull deformation and generalised osteoporosis. Recently, truncating mutations in the last exon of NOTCH2, a protein-coding gene, were found to be responsible. We present the case of a young woman with HCS in whom clinical and radiologic diagnosis was confirmed with DNA tests. © 2012 Elsevier Inc..
- Published
- 2013
19. Application of FRAX algorithm in a sample of Greek male population - A preliminary study
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Stathopoulos, I. Trovas, G. Lampropoulou-Adamidou, K. and Zafeiris, C. Tournis, S. Katsalira, A. Galanos, A. and Papaioannou, N.
- Published
- 2012
20. Correlation between bone mass index and fracture risk in a Greek female population
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Lampropoulou-Adamidou, K. Trovas, G. Stathopoulos, I. P. and Zafeiris, C. Tournis, S. Katsalira, A. Galanos, A. and Papaioannou, N. A.
- Published
- 2012
21. The role of vitamin D receptor gene polymorphisms in the bone mineral density of Greek postmenopausal women with low calcium intake
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Stathopoulou, M.G. Dedoussis, G.V.Z. Trovas, G. Theodoraki, E.V. Katsalira, A. Dontas, I.A. Hammond, N. Deloukas, P. Lyritis, G.P.
- Subjects
musculoskeletal diseases - Abstract
The aim of this study was to investigate the effect of common vitamin D receptor (VDR) gene polymorphisms on the bone mineral density (BMD) of Greek postmenopausal women. Healthy postmenopausal women (n=578) were recruited for the study. The BMD of the lumbar spine and hip was measured using dual-energy X-ray absorptiometry with the Lunar DPX-MD device. Assessment of dietary calcium intake was performed with multiple 24-h recalls. Genotyping was performed for the BsmI, TaqI and Cdx-2 polymorphisms of the VDR gene. The selected polymorphisms were not associated with BMD, osteoporosis or osteoporotic fractures. Stratification by calcium intake revealed that in the low calcium intake group (680 mg/day), no significant differences were observed within the genotypes for all polymorphisms. The VDR gene is shown to affect BMD in women with low calcium intake, while its effect is masked in women with higher calcium intake. This result underlines the significance of adequate calcium intake in postmenopausal women, given that it exerts a positive effect on BMD even in the presence of negative genetic predisposition. © 2011 Elsevier Inc.
- Published
- 2011
22. The weight bearing paraplegic arm
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Dionyssiotis, Y. Trovas, G. Petropoulou, K. Lyritis, G. P. and Papaioannou, N.
- Published
- 2011
23. Association of physical exercise and calcium intake with bone mass measured by quantitative ultrasound
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Dionyssiotis, Y. Paspati, I. Trovas, G. Galanos, A. Lyritis, G.P.
- Abstract
Background: Interventions other than medications in the management of osteoporosis are often overlooked. The purpose of this study was to investigate the association of physical activity and calcium intake with bone parameters.Methods: We measured the heel T-score and stiffness index (SI) in 1890 pre- and postmenopausal women by quantitative ultrasound (QUS) and assessed physical activity and dietary calcium intake by questionnaire. Participants were divided according to their weekly physical activity (sedentary, moderately active, systematically active) and daily calcium consumption (greater than or less than 800 mg/day).Results: SI values were significantly different among premenopausal groups (p = 0.016) and between sedentary and systematically active postmenopausal women (p = 0.039). QUS T-scores in systematically active premenopausal women with daily calcium intake > 800 mg/day were significantly higher than those in all other activity groups (p < 0.05) independent of calcium consumption.Conclusions: Systematic physical activity and adequate dietary calcium intake are indicated for women as a means to maximize bone status benefits. © 2010 Dionyssiotis et al; licensee BioMed Central Ltd.
- Published
- 2010
24. Assessment of musculoskeletal system in women with jumping mechanography
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Dionyssiotis, Y. Galanos, A. Michas, G. Trovas, G. Lyritis, G.P.
- Abstract
The purpose of this study was to investigate and add reference data about the musculoskeletal system in women. The mechanography system of the Leonardo™ platform (Novotec, Germany) was used to measure parameters of movement (velocity, force, power) in 176 healthy Greek women aged 20-79 years, separated according to age decade in six groups: group 1 (n = 12), 20-29 years; group 2 (n = 14), 30-39 years; group 3 (n = 33), 40-49 years; group 4 (n = 59), 50-59 years including 21 postmenopausal; group 5 (n = 31), 60-69 years including 12 postmenopausal; and group 6 (n = 27), 70-79 years all postmenopausal. This system measures forces applied to the plate over time, calculates through acceleration the vertical velocity of center of gravity and using force and velocity it calculates power of vertical movements. All women performed a counter-movement jump (brief squat before the jump) with freely moving arms. Weight was recorded on the platform before the jump and height was measured with a wall-mounted ruler. Body weight and body mass index were gradually increased; on the contrary height and all movement parameters except force (velocity, power) were statistically decreased during aging and after menopause. © 2009 Dionyssiotis et al, publisher and licensee Dove Medical Press Ltd.
- Published
- 2009
25. Quantitative Ultrasound of the Calcaneus in Greek Women: Normative Data are Different From the Manufacturer's Normal Range
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Trovas, G. Tsekoura, M. Galanos, A. Dionyssiotis, Y. Dontas, I. Lyritis, G. Papaioanou, N.
- Abstract
Quantitative ultrasound (QUS) is considered a useful method in evaluating bone status. The aim of the present study was to establish the reference data for the QUS measurements of the calcaneus in a Greek population. We measured a QUS parameter, stiffness index (SI), at the right calcaneus in 1500 women using the Achilles express Ultrasonometer (GE Lunar, Madison, WI). Participants were divided into 7 groups according to their age with a 10-yr span in each group. A progressive decline was found in the SI values after the age of 39 yr in the current study. When the SI values were compared between the age groups, high statistically significant differences were obvious, especially between 20-29 and 50- to 59-yr age groups and 60-69 and 70- to 79-yr age groups (p < 0.0005). Additionally, in the Greek normal range (GNR), the SI values of those aged 60-69 and 70-79 yr were significantly higher (81.84 ± 16.14 and 77.45 ± 17.65, respectively) than those in the manufacturer's normal range (MNR; 75.84 ± 16.14 and 69.10 ± 17.65, p < 0.005, respectively). Using the manufacturer's values, significantly fewer women were classified as normal (48% vs 67.3%), although those with T-score ≤ -2.5 were more (15.7%) compared with our Greek value (1.5%), and classification of subjects into risk-of-fracture categories was significantly different (kappa: 0.459, 66.2%, p < 0.0005). Multiple regression analysis showed that weight was the most significant predictor for SI in the age groups 30-39 (β = 0.280, p < 0.05), 40-49, 60-69, and 70-79 yr (β = 0.185, p < 0.005; β = 0.329, p < 0.0005; β = 0.494, p < 0.0005, respectively). Using conventional categories of risk, we report a different classification of our subjects from those proposed by the manufacturer, supporting the concept that data specific to the Greek population are necessary. © 2009 The International Society for Clinical Densitometry.
- Published
- 2009
26. Changes in biochemical indices of bone metabolism in post-menopausal women following a dietary intervention with fortified dairy products
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Manios, Y. Moschonis, G. Panagiotakos, D.B. Farajian, P. Trovas, G. Lyritis, G.P.
- Abstract
Background: In southern Europe, calcium supplementation alone is a common practice for osteoporosis prevention. The present study aimed to examine whether calcium supplementation alone could be as effective in achieving favourable changes on bone metabolism indices of Greek post-menopausal women as a holistic dietary approach combining consumption of dairy products fortified with calcium and vitamin D3 and nutrition counselling sessions for five winter months. Methods: A sample of 101 post-menopausal women was randomised to a dairy intervention group (IG: n = 39), receiving approximately 1200 mg of calcium and 7.5 μg of vitamin D3 per day via fortified dairy products and attending biweekly nutrition counselling sessions; a calcium-supplemented group (SG: n = 26) receiving a total of 1200 mg calcium per day; and a control group (CG: n = 36). Results: Regarding insulin-like growth factor (IGF)-I, a higher increase was observed for the IG compared to the changes in the CG and the SG (P = 0.049). Regarding serum parathyroid hormone (PTH) levels, the increase observed in the CG was higher than the changes observed in the other two groups but the differences were of marginal significance (P = 0.055). No significant differences were observed among groups regarding the changes in serum osteocalcin and type I collagen cross-linked C-telopeptide levels. Conclusions: The application of a holistic intervention approach combining nutrition counselling and consumption of fortified dairy products for five winter months induced some more favourable changes in IGF-I and PTH levels compared to calcium supplementation alone. Intervention periods longer than 5 months might be required to achieve significant differences among groups for bone remodelling biomarkers as well. © 2009 The Authors. Journal compilation. © 2009 The British Dietetic Association.
- Published
- 2009
27. Changes in biochemical indexes of bone metabolism and bone mineral density after a 12-mo dietary intervention program: The Postmenopausal Health Study
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Manios, Y. Moschonis, G. Trovas, G. Lyritis, G.P.
- Abstract
Background: In southern Europe, calcium supplementation alone is a common practice for osteoporosis prevention. Objective: We examined whether calcium supplementation could be as effective in achieving favorable bone mass changes in postmenopausal women as is a holistic dietary approach including dairy products fortified with calcium and vitamin D3. Design: A sample of 101 postmenopausal women were randomly assigned to a dairy intervention group (n = 39) who received daily ≈1200 mg Ca and 7.5 μg vitamin D3 via fortified dairy products and attended biweekly nutrition education sessions; a calcium-supplemented group (n = 26) who received a total of 1200 mg Ca/d; and a control group (n = 36). Results: The increases observed in serum concentrations of insulin-like growth factor I were greater in the dairy intervention group than in the 2 other groups, especially during the first 5 mo of intervention (P = 0.034). The decreases and increases observed during 5 and 12 mo, respectively, in serum 25-hydroxyvitamin D3 were significant in all groups (P = 0.050). Serum parathyroid hormone increased only in the control group, and serum type 1 collagen cross-linked C-telopeptide decreased only in the dairy intervention group during both 5 and 12 mo of intervention (P = 0.035 and 0.047, respectively). The dairy intervention group had greater improvements in pelvis (P = 0.040), total spine (P = 0.001), and total-body (P = 0.001) bone mineral density than did the other 2 groups. Conclusion: The application of a holistic intervention approach combining nutrition education and consumption of fortified dairy products for 12 mo can induce more favorable changes in biochemical indexes of bone metabolism and bone mineral density than can calcium supplementation alone. © 2007 American Society for Nutrition.
- Published
- 2007
28. Effect of primary hyperparathyroidism on volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in postmenopausal women
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Charopoulos, I. Tournis, S. Trovas, G. Raptou, P. Kaldrymides, P. Skarandavos, G. Katsalira, K. Lyritis, G.P.
- Abstract
Context: Primary hyperparathyroidism (PH) is characterized by inappropriate PTH elevation with or without hypercalcemia. Bone disease involves catabolic action at cortical sites, whereas cancellous sites and geometry might be relatively preserved. Objective: Our objective was to examine the effect of PH on quantitative and qualitative bone characteristics using peripheral quantitative computed tomography at the tibia in postmenopausal women with PH and healthy controls. Design and Setting: We conducted a cross-sectional study at a tertiary referral center. Patients: Fifty-two postmenopausal women with PH and 56 healthy controls, comparable for age and anthropometric measures, participated. Intervention: There was no intervention. Main Outcome Measure: We assessed volumetric bone mineral density (vBMD), bone mineral content (BMC), cortical thickness, cortical and trabecular area, peri- and endosteal circumference, and polar stress strength index assessed by peripheral quantitative computed tomography of the left tibia at 4% (cancellous), 14% (transition zone), and 38% (cortical) from the distal end. Results: At 4%, there was a significant decrease of trabecular BMC and vBMD (P < 0.001), effect particularly evident in hypercalcemic patients, whereas trabecular area was comparable. At 38%, cortical BMC(P < 0.01), vBMD (P < 0.01), area (P < 0.05), and thickness (P < 0.001) were reduced in the PH group, particularly in hypercalcemic patients. Endosteal circumference increased (P < 0.001), whereas periosteal circumference was comparable, indicating cancellization of cortical bone. At 14%, polar stress strength index was significantly decreased (P < 0.01) in hypercalcemic patients, indicating impairment of bone mechanical properties. Conclusions: Normocalcemic PH is characterized by catabolic actions at both cortical and cancellous sites (38 and 4%, respectively), an effect accentuated in hypercalcemic patients. Cortical geometric properties are adversely affected even in normocalcemic patients, whereas trabecular properties are generally preserved. Copyright © 2006 by The Endocrine Society.
- Published
- 2006
29. The symmetry of the medial collateral and anterior cruciate ligament properties: a biochemical study in the rat hind limb
- Author
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CHRISTOS YIANNAKOPOULOS, Ad, Kanellopoulos, Ia, Dontas, Trovas G, Ds, Korres, and Gp, Lyritis
- Subjects
Male ,Tensile Strength ,Medial Collateral Ligament, Knee ,Animals ,Stress, Mechanical ,Anterior Cruciate Ligament ,In Vitro Techniques ,Functional Laterality ,Biomechanical Phenomena ,Hindlimb ,Rats - Abstract
The medial collateral (MCL) and the anterior cruciate ligament (ACL) of the rat's knee are frequently used in biomedical research and occasionally in ligament healing studies. The contralateral normal ligament serves as a control. In this study the presence of symmetry in the biomechanical properties of the MCL and the ACL was investigated. Bilateral femur-MCL-tibia and femur-ACL-tibia preparations were obtained from the hind limbs of sixty rats and were subjected to tensile testing to failure under the same loading conditions. Tensile load to failure, stiffness and energy absorption capacity were measured and the mode of failure was recorded. All biomechanical parameters were not significantly different between the two knees of the same animal, although significant individual variation was evident. The most common mechanism of failure was mid-substance tear. Symmetry seems to exist in the biomechanical properties of the MCL and the ACL in the rat knee. When ligament healing is evaluated, increased group size is necessary and the use of a normal control group may be advisable. The contralateral normal knee ligament may serve as a control when the properties of an injured ligament are evaluated and when the parameters of tensile testing failure under similar load conditions are applied.
- Published
- 2005
30. Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women
- Author
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Papakitsou, EF Margioris, AN Dretakis, KE Trovas, G and Zoras, U Lyritis, G Dretakis, EK Stergiopoulos, K
- Abstract
Objectives: Aim of this study was to evaluate increased body mass index (BMI) as an anthropometric factor, predisposing to lower rates of bone turnover or changes in bone balance after menopause. Material and methods: For this purpose, we calculated BMI, and measured spinal (BMDSP) and femoral bone mineral density (BMDFN) and biochemical markers of bone formation (serum osteocalcin (S-OC), serum procollagen type I C propeptide (S-PICP), serum bone-specific alkaline phosphatase (S-B-ALP)) and resorption (urine N- and C-terminal cross-linking telopeptide of type I collagen (U-NTX-I and U-CTX-I), pyridinoline (U-PYD) and deoxypyridinoline (U-DPD)) in 130 healthy postmenopausal women, aged 46-85 years. Bone balance indices were calculated by subtracting z-scores of resorption markers from z-scores of formation markers, to evaluate bone balance. Results: S-PICP (r = -0.297, P = 0.002), S-OC (r = -0.173, P = 0.05) and bone balance indices (zPICP-zDPD) and (zPICP-zPYD) were negatively. correlated with BMI (r = -0.25, P = 0.01 and r = -0.21, P = 0.037) and with BMDSP (r = -0.196, P = 0.032 and r = -0.275 and P = 0.022). Women were grouped according to their BMI, in normals (BMI < 25 kg/m(2)), overweight (BMI = 25-30 kg/m(2)), and obese (BMI > 30 kg/m(2)). Overweight and obese women had approximately 30% lower levels of S-PICP compared to normals (68.11 +/- 24.85 and 66.41 +/- 24.93 ng/ml versus 97.47 +/- 23.36 ng/ml, respectively; P = 0.0001). zPICP-zDPD, zPICP-zCTX-I and zPICP-zPYD were significantly declined in obese women compared to normals (P = 0.0072, 0.02 and 0.0028). Conclusions: We conclude that in postmenopausal women, BMI is inversely associated with levels of collagen I formation marker, serum PICR In obesity formation of collagen I was reduced, in favor of degradation, but since this finding is not followed by simultaneous decrease in bone mineral density, it seems that increased body weight may have different effects on mature estrogen-deficient bone and extraskeletal tissues containing collagen I. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2004
31. Investigation of bone-muscle relationship with peripheral quantitative computed tomography in SCI
- Author
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Dionyssiotis, Y., primary, Trovas, G., additional, Papachristos, A., additional, Skarantavos, G., additional, and Papagelopoulos, P., additional
- Published
- 2014
- Full Text
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32. An application of mechanostat theory to protect muscle-bone unit in spinal cord injury
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Dionyssiotis, Y., primary, Skarantavos, G., additional, Papachristos, A., additional, Trovas, G., additional, Lyritis, G., additional, and Papagelopoulos, P., additional
- Published
- 2014
- Full Text
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33. Influence of weight gain on spine mineral density in postmenopausal women
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Trovas, G Lyritis, GP Galanos, A Raptou, P Katsiri, M
- Subjects
musculoskeletal diseases ,musculoskeletal, neural, and ocular physiology ,musculoskeletal system - Abstract
We studied the relationships between weight variables and spine bone mineral density (BMD) in 183 postmenopausal women aged 34-76 years. There was a significant positive correlation of current body mass index (cBMI) and % of ideal body weight (IBW) with BMD. Moreover, the increase in BMI and % IBW was also positively and significantly associated with a higher age-adjusted lumbar BMD. Weight gain, estimated as the difference between current body weight and past “ideal” body weight, was associated with significant age-adjusted BMD with a threshold of 17%, and postmenopausal women with a gain of over 17% had significantly higher spine BMD.
- Published
- 1999
34. A Randomized Trial of Nasal Spray Salmon Calcitonin in Men With Idiopathic Osteoporosis: Effects on Bone Mineral Density and Bone Markers
- Author
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Trovas, G. P., primary, Lyritis, G. P., additional, Galanos, A., additional, Raptou, P., additional, and Constantelou, E., additional
- Published
- 2002
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35. A Randomized Trial of Nasal Spray Salmon Calcitonin in Men With Idiopathic Osteoporosis: Effects on Bone Mineral Density and Bone Markers
- Author
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Dr. Trovas, G. P., Lyritis, G. P., Galanos, A., Raptou, P., and Constantelou, E.
- Abstract
In a 12‐month randomized, double‐blind, placebo‐controlled trial, we have studied the effects of intranasal salmon calcitonin (SCT) on bone mineral density (BMD) and biochemical markers of bone turnover. Twenty‐eight men with idiopathic osteoporosis aged 27‐74 years (mean, 52.4 years) were randomized to receive either nasal SCT (200 IU) or a nasal placebo daily for a period of 1 year. All the men received a daily supplement of 0.5 g of calcium. The men who received SCT had a mean (±SEM) increase in BMD of 7.1 ± 1.7% at the lumbar spine. In contrast, the men who received the placebo had an increase of 2.4 ± 1.5% (p> 0.05) for the comparison with baseline. The increase in lumbar BMD in the calcitonin group was significantly greater than that in the placebo group (p< 0.05). There were no significant changes in the femoral neck, trochanter, or Ward's triangle relative to both baseline and placebo after 12 months. Treatment with nasal SCT resulted in a significantly pronounced suppression of bone resorption markers (urinary deoxypyridinoline [DPD], type I cross‐linked N‐telopeptide [NTX], and type I cross‐linked C‐telopeptide [CTX]) and to a lesser extent in bone formation markers (serum bone‐specific alkaline phosphatase [BALP], osteocalcin [OC], serum C‐terminal procollagen type I extension peptides [PICP], and serum N‐terminal procollagen type I extension peptides [PINP]), whereas the placebo did not. Therapy was tolerated well and there were no treatment‐related adverse events. We conclude that intranasal SCT (200 IU daily) is safe and effective in increasing lumbar BMD and reducing bone turnover in men with idiopathic osteoporosis.
- Published
- 2002
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36. Bone And Soft Tissue Changes In Patients With Spinal Cord Injury And Multiple Sclerosis
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Dionyssiotis Yannis, Mavrogenis Andreas, Trovas Georgios, Skarantavos Grigorios, Papathanasiou Jannis, and Papagelopoulos Panayiotis
- Subjects
spinal cord injury ,multiple sclerosis ,bone ,muscle and fat loss ,osteoporosis ,травмы позвонкового мозга ,множественный склероз ,кости ,мышечная и липидная (жировая) потеря ,остеопороз ,Medicine - Abstract
In patients with spinal cord injury and multiple sclerosis, deterioration of body composition (changes in bone, fat and muscle mass) is associated with increased risk for diseases such as coronary artery heart disease, non-insulin dependent diabetes mellitus, lipid metabolism abnormalities, and osteoporotic fractures in these patients. Immobility leads to a changing pattern of loading in the paralyzed areas, and secondary alteration in structure. However, bone and soft tissue changes in these patients are usually neglected. The purpose of this article is to update on the pathophysiological mechanisms leading to bone and soft tissue changes, and to increase the awareness of the treating physicians with respect to bone, muscle and fat loss and their consequences aiming to obtain measures to prevent bone and soft tissue loss in these patients.
- Published
- 2014
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37. Coexistence of paget disease of bone and primary hyperparathyroidism; a diagnostic challenge
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Ip, Stathopoulos, Trovas G, Kalliopi Lampropoulou-Adamidou, Is, Benetos, Vamvakidis K, Vlachodimitropoulos D, Chronopoulos E, and Na, Papaioannou
- Subjects
Adenoma ,Male ,Parathyroidectomy ,Parathyroid Neoplasms ,Parathyroid Hormone ,Humans ,Calcium ,Hyperparathyroidism, Primary ,Osteitis Deformans ,Aged
38. Association of physical exercise and calcium intake with bone mass measured by quantitative ultrasound
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Galanos Antonios, Trovas Georgios, Paspati Ioanna, Dionyssiotis Yannis, and Lyritis Georgios P
- Subjects
Gynecology and obstetrics ,RG1-991 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Interventions other than medications in the management of osteoporosis are often overlooked. The purpose of this study was to investigate the association of physical activity and calcium intake with bone parameters. Methods We measured the heel T-score and stiffness index (SI) in 1890 pre- and postmenopausal women by quantitative ultrasound (QUS) and assessed physical activity and dietary calcium intake by questionnaire. Participants were divided according to their weekly physical activity (sedentary, moderately active, systematically active) and daily calcium consumption (greater than or less than 800 mg/day). Results SI values were significantly different among premenopausal groups (p = 0.016) and between sedentary and systematically active postmenopausal women (p = 0.039). QUS T-scores in systematically active premenopausal women with daily calcium intake > 800 mg/day were significantly higher than those in all other activity groups (p < 0.05) independent of calcium consumption. Conclusions Systematic physical activity and adequate dietary calcium intake are indicated for women as a means to maximize bone status benefits.
- Published
- 2010
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39. Robust Bioinformatics Approaches Result in the First Polygenic Risk Score for BMI in Greek Adults.
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Kafyra M, Kalafati IP, Dimitriou M, Grigoriou E, Kokkinos A, Rallidis L, Kolovou G, Trovas G, Marouli E, Deloukas P, Moulos P, and Dedoussis GV
- Abstract
Quantifying the role of genetics via construction of polygenic risk scores (PRSs) is deemed a resourceful tool to enable and promote effective obesity prevention strategies. The present paper proposes a novel methodology for PRS extraction and presents the first PRS for body mass index (BMI) in a Greek population. A novel pipeline for PRS derivation was used to analyze genetic data from a unified database of three cohorts of Greek adults. The pipeline spans various steps of the process, from iterative dataset splitting to training and test partitions, calculation of summary statistics and PRS extraction, up to PRS aggregation and stabilization, achieving higher evaluation metrics. Using data from 2185 participants, implementation of the pipeline enabled consecutive repetitions in splitting training and testing samples and resulted in a 343-single nucleotide polymorphism PRS yielding an R
2 = 0.3241 (beta = 1.011, p -value = 4 × 10-193 ) for BMI. PRS-included variants displayed a variety of associations with known traits (i.e., blood cell count, gut microbiome, lifestyle parameters). The proposed methodology led to creation of the first-ever PRS for BMI in Greek adults and aims at promoting a facilitating approach to reliable PRS development and integration in healthcare practice.- Published
- 2023
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40. Sarcopenia in patients with diabetes mellitus.
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Dionyssiotis Y, Athanassiou P, Papathanasiou J, Efstathopoulos E, Prokopidis K, Trovas G, and Kostoglou-Athanassiou I
- Subjects
- Aged, Body Composition, Female, Humans, Male, Muscle, Skeletal, Prevalence, Retrospective Studies, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 epidemiology, Sarcopenia complications, Sarcopenia etiology
- Abstract
Introduction: Diseases such as diabetes mellitus may be associated with adverse changes in body composition. Sarcopenia is characterized by a progressive and generalized loss of skeletal muscle mass and functionality., Aim: To investigate the relationship between type 2 diabetes mellitus (T2DM) and sarcopenia., Materials and Methods: In a retrospective, non-randomized study, 35 T2DM patients, aged 20-80 years, were assessed for sarcopenia prevalence compared to controls (n=16). Appendicular skeletal mass (ASM) (kg) was measured, and sarcopenia was defined as SMI <7.0 and <5.7 kg/m2, in males and females, respectively, using the European Working Group on Sarcopenia in Elderly (EWGOSP) definition. Low physical performance was defined as a walking speed of <0.8 m/s., Results: Incidence of sarcopenia was significantly higher in T2DM patients vs. controls (27% vs. 20%, p=0.01) and elderly vs. young participants (40% vs. 12%, p<0.001), respectively. Walking velocity was significantly lower in T2DM patients compared to male and female controls (1.08±0.22 vs. 1.23±0.18 and 1.07±0.26 vs. 1.26±0.16, respectively, p<0.001,)., Conclusions: A moderate prevalence of sarcopenia in patients with type 2 diabetes mellitus was observed, which appeared to increase significantly in older men. Finally, incidence of T2DM displayed decreased physical performance in both genders., (This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2022
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41. Sarcopenic Obesity in Individuals With Neurodisabilities: The SarcObeNDS Study.
- Author
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Dionyssiotis Y, Prokopidis K, Trovas G, Papadatou MC, Ananidis N, Tragoulias V, Lazarou E, Christaki E, Domazou M, Galanos A, and Tyllianakis M
- Subjects
- Aged, Body Mass Index, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Quality of Life, Brain Injuries, Traumatic complications, Obesity complications, Obesity epidemiology, Sarcopenia complications, Sarcopenia diagnosis, Sarcopenia epidemiology, Spinal Cord Injuries complications, Stroke complications
- Abstract
Introduction: Patients with neurodisabilities (NDS) are prone to alterations in body composition. Sarcopenic obesity (SO) is a condition characterized by increased adipose tissue accompanied by sarcopenia. The aim of this study was to investigate the prevalence of SO in patients with NDS, including stroke, spinal cord, and traumatic brain injuries., Methods: The study Sarcopenic Obesity in NeuroDisabled Subjects (acronym: SarcObeNDS) was a cross-sectional study of hospitalized patients ( n = 82) and healthy controls ( n = 32) with a mean age of 60.00 ± 14.22 years old. SO and sarcopenia were assessed through total body fat % (TBF %), fat mass index (fat mass to height
2 : FMI = FM/h2 ; kg/m2 ), and skeletal muscle index (appendicular skeletal muscle to height2 : SMI = ASM/h2 ; kg/m2 ) via full-body dual-energy X-ray absorptiometry (DXA). This study was registered in the international database ClinicalTrials.gov with the unique identification number NCT03863379., Results: A statistically significant difference was found in SMI (7.18 ± 0.95 vs. 6.00 ± 1.13 kg/m2 , p < 0.001) between controls and patients with NDS. No statistical significance was found for TBF ( p = 0.783) and FMI ( p = 0.143) between groups. The results remained the same after controlling the results for gender and BMI. A strong positive correlation was demonstrated between BMI and TBF for the total population ( r = 0.616, p < 0.001), the control group ( r = 0.616, p < 0.001), and patients with NDS ( r = 0.728, p < 0.001)., Conclusion: In summary, we observed significantly lower BMI and SMI scores in both genders compared to healthy controls. At the clinical level, a timely diagnosis and rapid treatment of sarcopenia and/or obesity in this population may prevent further metabolic repercussions accompanied by higher functional decline and lower quality of life., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Dionyssiotis, Prokopidis, Trovas, Papadatou, Ananidis, Tragoulias, Lazarou, Christaki, Domazou, Galanos and Tyllianakis.)- Published
- 2022
- Full Text
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42. Does Vitamin D affects changes in volumetric bone mineral density and architecture in postmenopausal women after conservatively treated distal radius fractures?
- Author
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Raptis K, Makris K, Trovas G, Galanos A, Koutserimpas C, Papaioannou N, Vlamis I, Vlasis K, and Tournis S
- Subjects
- Aged, Bone Remodeling physiology, Female, Humans, Middle Aged, Prospective Studies, Tomography, X-Ray Computed methods, Vitamin D Deficiency blood, Vitamin D Deficiency diagnostic imaging, Bone Density physiology, Conservative Treatment methods, Postmenopause blood, Radius Fractures blood, Radius Fractures diagnostic imaging, Vitamin D blood
- Abstract
Objective: We examined the role of vitamin D on volumetric bone mineral density (vBMD) and architecture during the first week's post-fracture in postmenopausal women (PMW) with distal radial fractures (DRF) treated conservatively using peripheral Quantitative Computed Tomography (pQCT)., Methods: Patients were classified into 2 groups according to initial median 25(OH)D level; Group A (25(OH)D ≥15 ng/ml) and group B (25(OH)D <15 ng/ml). All patients were followed for 12 weeks at three visits: baseline, 6 weeks and 12 weeks post fracture. pQCT was performed at baseline in fractured and contralateral non-fractured radius and at 6
th and 12th week on the fractured side., Results: 39 patients completed the protocol. Mean 25(OH)D levels were 15.60±7.35 ng/ml (3.5-41.7). Trabecular (trab) bone mineral content (BMC) and trabvBMD increased at 6 wk. vs. baseline (p<0.001). Cortical BMC, cortvBMD and cross- sectional area (CSA) progressively decreased (p<0.001) during the 12 weeks. There was no interaction between baseline 25(OH)D levels and changes in trabecular and cortical BMC, vBMD and CSA. Advanced age and higher CTX and P1NP were associated with higher cortical bone loss., Conclusion: Vitamin D deficiency does not affect the early architectural changes after a DRF. Advanced age and higher bone remodeling were associated with higher cortical bone loss, probably related to immobilization and independent of vitamin D levels., Competing Interests: The authors have no conflict of interest.- Published
- 2021
43. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.
- Author
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Argyrou C, Karlafti E, Lampropoulou-Adamidou K, Tournis S, Makris K, Trovas G, Dontas I, and Triantafyllopoulos IK
- Subjects
- Aged, Bone Density drug effects, Bone Density physiology, Bone Diseases, Metabolic blood, Bone Diseases, Metabolic diagnosis, Bone Remodeling physiology, Dietary Supplements, Drug Therapy, Combination, Female, Humans, Middle Aged, Peptide Fragments administration & dosage, Postmenopause blood, Treatment Outcome, Bone Diseases, Metabolic drug therapy, Bone Remodeling drug effects, Calcium Compounds administration & dosage, Cholecalciferol administration & dosage, Collagen administration & dosage, Lactates administration & dosage, Postmenopause drug effects
- Abstract
Objectives: Collagen peptides (CPs) seem to exert beneficial effects on bone and may have a role as a treatment option. In the present randomized prospective study, we aimed to examine the efficacy, as expressed by changes in P1NP and CTX, and the tolerability of 3-month supplementation of calcium, vitamin D with or without bioactive CPs in postmenopausal women with osteopenia., Methods: Fifty-one female, postmenopausal women with osteopenia were allocated to two groups: Group A received a sachet containing 5 g CPs, 3.6 g calcium lactate (equivalent to 500 mg of elemental calcium) and 400 IU vitamin D3 and group B received a chewable tablet containing 1.25 g calcium carbonate (equivalent to 500 mg of elemental calcium) and 400 IU vitamin D3 daily., Results: In group A, the P1NP levels significantly decreased by 13.1% (p<0.001) and CTX levels decreased by 11.4% (p=0.058) within 3 months of supplementation. In group B, P1NP and CTX did not change. Group A presented better compliance in comparison to group B and no adverse events contrary to group B., Conclusions: These findings may reflect the reduction of the increased bone turnover in postmenopausal women with the use of calcium, vitamin D and CPs supplements. The addition of CPs in a calcium and vitamin D supplement may enhance its already known positive effect on bone metabolism. Clinical Trial ID: NCT03999775., Competing Interests: The study was supported by VIvapharm SA. The necessary amount of Colabone® sachets, containing 5 g bioactive collagen peptides (Fortibone®), 3.6 g calcium lactate (equivalent to 500 mg of elemental calcium) and 400 IU vitamin D3 for the conduction of the study was also provided by Vivapharm SA. The authors have nothing to declare.
- Published
- 2020
44. Dietary Patterns of Greek Adults and Their Associations with Serum Vitamin D Levels and Heel Quantitative Ultrasound Parameters for Bone Health.
- Author
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Grigoriou E, Trovas G, Papaioannou N, Dontas I, Makris K, Apostolou-Karampelis K, and Dedoussis G
- Subjects
- Adult, Age Factors, Aged, Body Mass Index, Cross-Sectional Studies, Diet Surveys, Exercise, Feeding Behavior, Female, Greece, Humans, Life Style, Male, Middle Aged, Principal Component Analysis, Vitamin D blood, Bone Density physiology, Diet adverse effects, Heel diagnostic imaging, Ultrasonography, Vitamin D analogs & derivatives
- Abstract
The aim of this study is to investigate the dietary patterns which indicate the nutritional habits of Greek adults and their effects on serum 25(OH)D levels and quantitative ultrasound (QUS) parameters for bone health. This study is part of OSTEOS, an observational cross-sectional study. In total, 741 adults from rural and urban areas throughout Greece were recruited. A validated food frequency questionnaire (FFQ) was used for assessment of the population's dietary habits. Serum 25(OH)D was measured by enzyme immunoassay; QUS parameters were assessed with an Achilles device. Principal component analysis (PCA) was carried out for dietary pattern determination, and univariate analysis of variance was used for the assessment of 25(OH)D, broadband ultrasound attenuation (BUA), speed of sound (SOS), and stiffness index (SI) determinants. Six dietary patterns explain 52.2% of the variability of Greek adults' nutritional habits. The 'vegetables-fruit' dietary pattern explains the biggest rate of variability. Determinants of serum 25(OH)D are body mass index (BMI), elderly status, summer sun exposure, organized physical activity, a 'healthy' pattern in winter months, and adherence to a 'sweet' pattern. Determinants of QUS parameters are age, BMI, sedentary time, organized physical activity participation, and adherence to a 'healthy' pattern.
- Published
- 2020
- Full Text
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45. Letter to the Editor: "Evaluation of Bone Mineral Density Using DXA and cQCT in Postmenopausal Patients Under Thyrotropin Suppressive Therapy".
- Author
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Tournis S, Trovas G, Triantafyllopoulos IK, and Balanika AP
- Subjects
- Absorptiometry, Photon, Humans, Postmenopause, Thyroxine, Bone Density, Thyrotropin
- Published
- 2019
- Full Text
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46. Hypercalcitoninaemia in pseudohypo-parathyroidism type 1A and type 1B.
- Author
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Yavropoulou MP, Chronopoulos E, Trovas G, Avramidis E, Elli FM, Mantovani G, Zebekakis P, and Yovos JG
- Abstract
Pseudohypoparathyroidism (PHP) is a heterogeneous group of rare endocrine disorders characterised by normal renal function and renal resistance to the action of the parathyroid hormone. Type 1A (PHP1A), which is the most common variant, also include developmental and skeletal defects named as Albright hereditary osteodystrophy (AHO). We present two cases, a 54- and a 33-year-old male diagnosed with PHP who were referred to us for persistently high levels of serum calcitonin. AHO and multinodular goitre were present in the 54-year-old male, while the second patient was free of skeletal deformities and his thyroid gland was of normal size and without nodular appearance. We performed GNAS molecular analysis (methylation status and copy number analysis by MS-MLPA) in genomic DNA samples for both patients. The analysis revealed a novel missense variant c.131T>G p.(Leu44Pro) affecting GNAS exon 1, in the patient with the clinical diagnosis of PHP1A. This amino acid change appears to be in accordance with the clinical diagnosis of the patient. The genomic DNA analysis of the second patient revealed the presence of the recurrent 3-kb deletion affecting the imprinting control region localised in the STX16 region associated with the loss of methylation (LOM) at the GNAS A/B differentially methylated region and consistent with the diagnosis of an autosomal dominant form of PHP type 1B (PHP1B). In conclusion, hypercalcitoninaemia may be encountered in PHP1A and PHP1B even in the absence of thyroid pathology. Learning points: We describe a novel missense variant c.131T>G p.(Leu44Pro) affecting GNAS exon 1 as the cause of PHP1A. Hypercalcitoninaemia in PHP1A is considered an associated resistance to calcitonin, as suggested by the generalised impairment of Gsα-mediated hormone signalling. GNAS methylation defects, as in type PHP1B, without thyroid pathology can also present with hypercalcitoninaemia.
- Published
- 2019
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47. Sarcopenia: From definition to treatment.
- Author
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Dionyssiotis Y, Kapsokoulou A, Samlidi E, Angoules AG, Papathanasiou J, Chronopoulos E, Kostoglou-Athanassiou I, and Trovas G
- Subjects
- Diet, Exercise, Humans, Muscle Strength, Muscle, Skeletal, Sarcopenia physiopathology, Aging, Sarcopenia diagnosis, Sarcopenia therapy
- Published
- 2017
- Full Text
- View/download PDF
48. Letter to the Editor: Severe Rebound-Associated Vertebral Fractures After Denosumab Discontinuation: Nine Clinical Cases Report.
- Author
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Trovas G
- Subjects
- Bone Density Conservation Agents, Humans, Osteoporosis, Postmenopausal, Osteoporotic Fractures, Denosumab, Spinal Fractures
- Published
- 2017
- Full Text
- View/download PDF
49. Effect of Calcitriol on FGF23 Level in Healthy Adults and its Dependence on Phosphate Level.
- Author
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Georgiadou E, Marketou H, Trovas G, Dontas I, Papaioannou N, Makris K, Galanos A, and Papavassiliou AG
- Subjects
- Adult, Bone Density Conservation Agents pharmacology, Enzyme-Linked Immunosorbent Assay, Female, Fibroblast Growth Factor-23, Healthy Volunteers, Humans, Male, Middle Aged, Young Adult, Biomarkers blood, Calcitriol pharmacology, Fibroblast Growth Factors blood, Parathyroid Hormone blood, Phosphates blood
- Abstract
Aim: To evaluate the short-term effects of calcitriol and sevelamer hydrochloride on fibroblast growth factor-23 (FGF23) in humans and to determine whether the effect is direct or indirect through calcitriol-induced increased absorption of phosphorus from the intestine., Patients and Methods: A total of 15 healthy individuals were tested at three time points and stages, for 24 h and at 1-week intervals. During each stage, blood samples were taken at three time points (0, 8 and 24 h); baseline stage: under no intervention; second stage, while receiving 0.5 μg calcitriol orally twice daily; and at the third stage, while receiving 0.5 μg calcitriol orally twice daily and sevelamer hydrochloride during meals. The changes in FGF23, parathyroid hormone, calcitriol, Ca, and phosphorus were determined., Results: During calcitriol administration, the FGF23 level changed significantly (p=0.008), with the level at 24 h levels being significantly higher than at 8 h (8.8 pg/ml vs. 13.0 pg/ml, p=0.036). There was a statistically significant difference in the percentage change, among the three stages, at time 8 to 24 h and 0 to 24 h for FGF23 (p=0.014 and p=0.015, respectively), with significant differences between baseline vs. calcitriol for 8 to 24 h FGF23 change (-9.23% vs. 26.98%, p=0.003) and a trend between baseline vs. calcitriol (p=0.061) and calcitriol plus sevelamer (p=0.069) for 0 to 24 h FGF23 change., Conclusion: Administration of calcitriol to healthy individuals increases the circulating level of FGF23 within 24 h. Combined calcitriol and sevelamer administration restrains the increase of FGF23, suggesting that calcitriol-induced increased absorption of phosphate from the intestine might also be involved in the increase of FGF23., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2017
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50. Impact on bone and muscle area after spinal cord injury.
- Author
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Dionyssiotis Y, Stathopoulos K, Trovas G, Papaioannou N, Skarantavos G, and Papagelopoulos P
- Abstract
Spinal cord injury (SCI) causes inactivation and consequent unloading of affected skeletal muscle and bone. This cross-sectional study investigated correlations of muscle and bone in spinal cord-injured subjects compared with able-bodied subjects. Thirty-one complete SCI paraplegics were divided according to the neurological level of injury (NLoI) into group A (n=16, above thoracic 7 NLoI, age: 33±16 years, duration of paralysis (DoP): 6±6 years) and group B (n=15, thoracic 8-12, age: 39±14 years, DoP: 5.6±6 years), compared with 33 controls (group C). All were examined with peripheral quantitative computed tomography at 66% of tibia length (bone and muscle area, bone/muscle area ratio). In able-bodied subjects, muscle area was correlated with bone area (P<0.001, r=0.88). Groups A and B differed significantly from the control group in terms of bone and muscle area (P<0.001). In paraplegics, less muscle per unit of bone area (bone/muscle area ratio) was found compared with controls (P<0.001). Bone area was negatively correlated with the DoP in the total paraplegic group (r=-0.66, P<0.001) and groups A and B (r=-0.77, P=0.001 vs r=-0.52, P=0.12, respectively). Muscle area and bone/muscle ratio area correlations in paraplegic groups with DoP were weak. Paraplegic subjects who performed standing and therapeutic walking had significantly higher bone area (P=0.02 and P=0.013, respectively). The relationship between bone and muscle was consistent in able-bodied subjects and it was predictably altered in those with SCI, a clinical disease affecting bone and muscle.
- Published
- 2015
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