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Fabio Rinaldi,1,2 Daniela Pinto,1,2 Anna Trink,2 Giammaria Giuliani,1 Adele Sparavigna3 1Giuliani SpA, Research and Development Department, Milan, Italy; 2IHRF, International Hair Research Foundation, Milan, Italy; 3Derming, Clinical Research, and Bioengineering Institute, Monza, ItalyCorrespondence: Fabio RinaldiGiuliani SpA, Research and Development Department, Palagi, 2, Milan, 20129, ItalyTel +39-02-76006089Fax +39 0220541Email fabio.rinaldi@studiorinaldi.comAbstract: Nowadays, the most advanced skin anti-aging treatments are addressed to restore the extracellular matrix (ECM) homeostasis. ECM is considered the main player not only as physical support of the tegument but also at the biochemical level, thanks to its capacity to exchange nutrients, water, cellular mediators, and growth factors within and between cells. This study aimed to evaluate the in vitro and in vivo efficacy and aesthetic performance of a brand-new intracutaneous filler. The latter is based on novel concepts: besides filling it exerts a homeostatic balance of nutrients able to delay the skin aging process by sustaining physiological rejuvenation of the tissue and in the surrounding injection/implantation area. The brand-new intracutaneous filler was tested for in vitro capacity to stimulate extracellular matrix components production. Therefore, a single session for injection of the product under study was performed by a specialized dermatologist, using the bolus technique on the zygomatic protuberance of 20 healthy female subjects with midface volume loss, caused by aging. Results confirmed the important and long-term volumizing, anti-wrinkle, the hydrating activity of this product after one single injection session. The biological outcomes also support product effectiveness in skin structure restoration.Keywords: fillers, hyaluronic acid, α 1-R-collagen, carboxymethylcellulose, dipeptides, amino acids