1. Reduction in Mortality With Availability of Antiretroviral Therapy for Children With Perinatal HIV-1 Infection
- Author
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Martino, De, Tovo, M, Balducci, Pa, Galli, L, Gabiano, L, Rezza, C, G, Amnd, Pezzotti, for the Italian Register for HIV infection in Children, P., the Italian National AIDS Registry: Partecipants: Osimani, P, Bari, Di, Larovere, C, Ruggeri, M, Masi, M, Specchia, M, Battisti, L, Duse, L, Crispino, M, Carrara, P, Pintor, C, Dedoni, C, Dessì, C, Loriano, D, Anastasio, E, Bezzi, E, T, Luca, De, Farina, M, Vierucci, S, Bassetti, A, Pontali, E, Boni, E, Marazzi, S, Tasso, Mg, Giovanettoni, L, Salvini, F, Pinzani, R, Marchisio, P, Viganò, P, Tornaghi, A, Zuccotti, R, Riva, Vg, Giovannini, E, Liprieri, R, Copnio, S, Ferraris, S, Cellini, G, Baraldi, M, Guarino, C, A, Berni, Canani, Tarallo, R, Giaquinto, L, Ruga, C, Rampon, E, O, Dalle, Nogare, Sanfilippo, Er, Romano, A, Benaglia, A, Dodi, G, Caselli, I, Maccabruni, D, Pacati, A, I, and Consolini, Rita
- Subjects
Pregnancy ,Longitudinal study ,medicine.medical_specialty ,Pediatrics ,business.industry ,Mortality rate ,Birth weight ,Gestational age ,General Medicine ,medicine.disease ,Surgery ,Pharmacotherapy ,Acquired immunodeficiency syndrome (AIDS) ,Medicine ,business ,Survival analysis - Abstract
ContextSince the introduction of combined antiretroviral therapy, mortality rates in adults with human immunodeficiency virus type 1 (HIV-1) infection have decreased. However, little information is available outside the setting of controlled trials on survival of perinatally HIV-infected children treated with antiretroviral therapy.ObjectiveTo assess effect of availability of antiretroviral therapy on decreasing mortality in perinatally HIV-infected children.DesignPopulation-based, multicenter longitudinal study involving data collected by the Italian Register for HIV Infection in Children.SettingA network of 106 pediatric clinical centers.SubjectsA total of 1142 children born between November 1980 and December 1997 with perinatally acquired HIV infection with a median follow-up of 5.9 years.Main Outcome MeasureTime to HIV-related death calculated for birth cohort and calendar period and grouped by distribution of predominant type of antiretroviral therapy administered over time.ResultsSurvival was longer in the 1996-1997 birth cohort (crude relative hazard [RH] of death, 0.39; 95% confidence interval [CI], 0.15-0.96) and 1996-1998 calendar period (crude RH of death, 0.65; 95% CI, 0.45-0.95) than in birth cohort and calendar period 1980-1995, but not when adjusted for maternal antiretroviral treatment during pregnancy and clinical condition at time of delivery, gestational age, and birth weight (adjusted RH of death, 0.55; 95% CI, 0.20-1.50, for birth cohort; and adjusted RH of death, 0.71, 95% CI, 0.43-1.16, for calendar period). In a multivariate model with 1980-1995 as comparison, the 1996-1997 birth cohort had an RH of 0.57 (95% CI, 0.22-1.47; P=.27) but RH for calendar period 1996-1998 was 0.63 (95% CI, 0.47-0.85; P
- Published
- 2000
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