134 results on '"Topinkova, E"'
Search Results
2. Preserving Mobility in Older Adults with Physical Frailty and Sarcopenia: Opportunities, Challenges, and Recommendations for Physical Activity Interventions
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Billot M, Calvani R, Urtamo A, Sánchez-Sánchez JL, Ciccolari-Micaldi C, Chang M, Roller-Wirnsberger R, Wirnsberger G, Sinclair A, Vaquero-Pinto N, Jyväkorpi S, Öhman H, Strandberg T, Schols JMGA, Schols AMWJ, Smeets N, Topinkova E, Michalkova H, Bonfigli AR, Lattanzio F, Rodríguez-Mañas L, Coelho-Júnior H, Broccatelli M, D'Elia ME, Biscotti D, Marzetti E, and Freiberger E
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physical exercise ,muscle mass ,strength ,walking ,balance ,better aging ,Geriatrics ,RC952-954.6 - Abstract
Maxime Billot,1,2 Riccardo Calvani,3,4 Annele Urtamo,5 Juan Luis Sánchez-Sánchez,6 Cecilia Ciccolari-Micaldi,1 Milan Chang,7,8 Regina Roller-Wirnsberger,9 Gerhard Wirnsberger,10 Alan Sinclair,11 Nieves Vaquero-Pinto,12 Satu Jyväkorpi,5 Hanna Öhman,5 Timo Strandberg,13,14 Jos MGA Schols,15 Annemie MWJ Schols,16 Nick Smeets,17 Eva Topinkova,18 Helena Michalkova,19 Anna Rita Bonfigli,20 Fabrizia Lattanzio,20 Leocadio Rodríguez-Mañas,21 Hélio Coelho-Júnior,4 Marianna Broccatelli,4 Maria Elena D’Elia,4 Damiano Biscotti,4 Emanuele Marzetti,3,4 Ellen Freiberger22 1Clinical Gerontology, University Hospital of Limoges, Limoges, France; 2PRISMATICS (Predictive Research in Spine/Neurostimulation Management and Thoracic Innovation in Cardiac Surgery), Poitiers University Hospital, Poitiers, France; 3Università Cattolica del Sacro Cuore, Rome, Italy; 4Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy; 5University of Helsinki, Department of General Practice and Primary Health Care, Helsinki University Central Hospital, Unit of Primary Health Care, Helsinki, Finland; 6Foundation for Biomedical Research Getafe University Hospital, Madrid, Spain; 7Faculty of Health Promotion, Sports and Leisure Studies, School of Education, University of Iceland, Reykjavik, Iceland; 8The Icelandic Gerontological Research Center, Landspitali University Hospital and University of Iceland, Reykjavik, Iceland; 9Medical University of Graz, Department of Internal Medicine, Graz, Austria; 10Medical University of Graz, Division of Nephrology, Department of Internal Medicine, Graz, Austria; 11Foundation for Diabetes Research in Older People, Diabetes Frail Ltd., Luton, UK; 12University Hospital of Ramon Cajal IRYCIS, Madrid, Spain; 13University of Helsinki, Clinicum, Helsinki, Finland; Helsinki University Hospital, Medicine and Rehabilitation, Helsinki, Finland; 14University of Oulu, Center for Life Course Health Research, Oulu, Finland; 15Department of Health Services Research, Maastricht University Medical Center, Maastricht, The Netherlands; 16Department of Respiratory Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, The Netherlands; 17Department of Health & Fitness, Maastricht University Medical Center, Maastricht, The Netherlands; 18 First Faculty of Medicine, Charles University, Prague, Czech Republic; 19Faculty of Social and Health Sciences, South Bohemian University, Ceske Budejovice, Czech Republic; 20Scientific Direction, IRCCS INRCA, Ancona, Italy; 21Geriatrics Service, University Hospital of Getafe, Madrid, Spain; 22Institute for Biomedicine of Aging, FAU Erlangen-Nürnberg, Nürnberg, GermanyCorrespondence: Maxime Billot CHU De Poitiers, PRISMATICS (Predictive Research in Spine/Neurostimulation Management and Thoracic Innovation in Cardiac Surgery)Poitiers University Hospital, 2 Rue De La Miléterie, Poitiers 86021, FranceTel +33 549 443 224Email maxime.billot2@gmail.comAbstract: One of the most widely conserved hallmarks of aging is a decline in functional capabilities. Mobility loss is particularly burdensome due to its association with negative health outcomes, loss of independence and disability, and the heavy impact on quality of life. Recently, a new condition, physical frailty and sarcopenia, has been proposed to define a critical stage in the disabling cascade. Physical frailty and sarcopenia are characterized by weakness, slowness, and reduced muscle mass, yet with preserved ability to move independently. One of the strategies that have shown some benefits in combatting mobility loss and its consequences for older adults is physical activity. Here, we describe the opportunities and challenges for the development of physical activity interventions in people with physical frailty and sarcopenia. The aim of this article is to review age-related physio(patho)logical changes that impact mobility in old age and to provide recommendations and procedures in accordance with the available literature.Keywords: physical exercise, muscle mass, strength, walking, balance, better aging
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- 2020
3. eHealth in Geriatric Rehabilitation: An International Survey of the Experiences and Needs of Healthcare Professionals.
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Kraaijkamp, J.J.M., Persoon, A., Aurelian, S., Bachmann, S., Cameron, I.D., Choukou, M.A., Dockery, F., Eruslanova, K., Gordon, A.L., Grund, S., Kim, H., Maier, A.B., Pérez Bazan, L.M., Pompeu, J.E., Topinkova, E., Vassallo, M.A., Chavannes, N.H., Achterberg, W.P., Dam van Isselt, E.F. van, Kraaijkamp, J.J.M., Persoon, A., Aurelian, S., Bachmann, S., Cameron, I.D., Choukou, M.A., Dockery, F., Eruslanova, K., Gordon, A.L., Grund, S., Kim, H., Maier, A.B., Pérez Bazan, L.M., Pompeu, J.E., Topinkova, E., Vassallo, M.A., Chavannes, N.H., Achterberg, W.P., and Dam van Isselt, E.F. van
- Abstract
Contains fulltext : 294747.pdf (Publisher’s version ) (Open Access), While eHealth can help improve outcomes for older patients receiving geriatric rehabilitation, the implementation and integration of eHealth is often complex and time-consuming. To use eHealth effectively in geriatric rehabilitation, it is essential to understand the experiences and needs of healthcare professionals. In this international multicentre cross-sectional study, we used a web-based survey to explore the use, benefits, feasibility and usability of eHealth in geriatric rehabilitation settings, together with the needs of working healthcare professionals. Descriptive statistics were used to summarize quantitative findings. The survey was completed by 513 healthcare professionals from 16 countries. Over half had experience with eHealth, although very few (52 of 263 = 20%) integrated eHealth into daily practice. Important barriers to the use or implementation of eHealth included insufficient resources, lack of an organization-wide implementation strategy and lack of knowledge. Professionals felt that eHealth is more complex for patients than for themselves, and also expressed a need for reliable information concerning available eHealth interventions and their applications. While eHealth has clear benefits, important barriers hinder successful implementation and integration into healthcare. Tailored implementation strategies and reliable information on effective eHealth applications are needed to overcome these barriers.
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- 2023
4. Multicomponent intervention to prevent mobility disability in frail older adults:randomised controlled trial (SPRINTT project)
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Bernabei, R. (Roberto), Landi, F. (Francesco), Calvani, R. (Riccardo), Cesari, M. (Matteo), Del Signore, S. (Susanna), Anker, S. D. (Stefan D.), Bejuit, R. (Raphael), Bordes, P. (Philippe), Cherubini, A. (Antonio), Cruz-Jentoft, A. J. (Alfonso J.), Di Bari, M. (Mauro), Friede, T. (Tim), Ayestaran, C. G. (Carmen Gorostiaga), Goyeau, H. (Harmonie), Jonsson, P. V. (Palmi, V), Kashiwa, M. (Makoto), Lattanzio, F. (Fabrizia), Maggio, M. (Marcello), Mariotti, L. (Luca), Miller, R. R. (Ram R.), Rodriguez-Manas, L. (Leocadio), Roller-Wirnsberger, R. (Regina), Ryznarova, I. (Ingrid), Scholpp, J. (Joachim), Schols, A. M. (Annemie M. W. J.), Sieber, C. C. (Cornel C.), Sinclair, A. J. (Alan J.), Skalska, A. (Anna), Strandberg, T. (Timo), Tchalla, A. (Achille), Topinkova, E. (Eva), Tosato, M. (Matteo), Vellas, B. (Bruno), von Haehling, S. (Stephan), Pahor, M. (Marco), Roubenoff, R. (Ronenn), Marzetti, E. (Emanuele), Bernabei, R. (Roberto), Landi, F. (Francesco), Calvani, R. (Riccardo), Cesari, M. (Matteo), Del Signore, S. (Susanna), Anker, S. D. (Stefan D.), Bejuit, R. (Raphael), Bordes, P. (Philippe), Cherubini, A. (Antonio), Cruz-Jentoft, A. J. (Alfonso J.), Di Bari, M. (Mauro), Friede, T. (Tim), Ayestaran, C. G. (Carmen Gorostiaga), Goyeau, H. (Harmonie), Jonsson, P. V. (Palmi, V), Kashiwa, M. (Makoto), Lattanzio, F. (Fabrizia), Maggio, M. (Marcello), Mariotti, L. (Luca), Miller, R. R. (Ram R.), Rodriguez-Manas, L. (Leocadio), Roller-Wirnsberger, R. (Regina), Ryznarova, I. (Ingrid), Scholpp, J. (Joachim), Schols, A. M. (Annemie M. W. J.), Sieber, C. C. (Cornel C.), Sinclair, A. J. (Alan J.), Skalska, A. (Anna), Strandberg, T. (Timo), Tchalla, A. (Achille), Topinkova, E. (Eva), Tosato, M. (Matteo), Vellas, B. (Bruno), von Haehling, S. (Stephan), Pahor, M. (Marco), Roubenoff, R. (Ronenn), and Marzetti, E. (Emanuele)
- Abstract
Objective: To determine whether a multicomponent intervention based on physical activity with technological support and nutritional counselling prevents mobility disability in older adults with physical frailty and sarcopenia. Design: Evaluator blinded, randomised controlled trial. Setting: 16 clinical sites across 11 European countries, January 2016 to 31 October 2019. Participants: 1519 community dwelling men and women aged 70 years or older with physical frailty and sarcopenia, operationalised as the co-occurrence of low functional status, defined as a short physical performance battery (SPPB) score of 3 to 9, low appendicular lean mass, and ability to independently walk 400 m. 760 participants were randomised to a multicomponent intervention and 759 received education on healthy ageing (controls). Interventions: The multicomponent intervention comprised moderate intensity physical activity twice weekly at a centre and up to four times weekly at home. Actimetry data were used to tailor the intervention. Participants also received personalised nutritional counselling. Control participants received education on healthy ageing once a month. Interventions and follow-up lasted for up to 36 months. Main outcome measures: The primary outcome was mobility disability (inability to independently walk 400 m in <15 minutes). Persistent mobility disability (inability to walk 400 m on two consecutive occasions) and changes from baseline to 24 and 36 months in physical performance, muscle strength, and appendicular lean mass were analysed as pre-planned secondary outcomes. Primary comparisons were conducted in participants with baseline SPPB scores of 3–7 (n=1205). Those with SPPB scores of 8 or 9 (n=314) were analysed separately for exploratory purposes. Results: Mean age of the 1519 participants (1088 women) was 78.9 (standard deviation 5.8) years. The average follow-up was 26.4 (SD 9.5) months. Among participants with SPPB scores of 3–7, mobility disability occur
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- 2022
5. Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project)
- Author
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Bernabei, Roberto, Landi, Francesco, Calvani, Riccardo, Cesari, M., Del Signore, S., Anker, S. D., Bejuit, R., Bordes, P., Cherubini, A., Cruz-Jentoft, A. J., Di Bari, M., Friede, T., Ayestaran, C. G., Goyeau, H., Jonsson, P. V., Kashiwa, M., Lattanzio, F., Maggio, M., Mariotti, L., Miller, R. R., Rodriguez-Manas, L., Roller-Wirnsberger, R., Ryznarova, I., Scholpp, J., Schols, A. M. W. J., Sieber, C. C., Sinclair, A. J., Skalska, A., Strandberg, T., Tchalla, A., Topinkova, E., Tosato, Matteo, Vellas, B., Von Haehling, S., Pahor, M., Roubenoff, R., Marzetti, Emanuele, Bernabei R. (ORCID:0000-0002-9197-004X), Landi F. (ORCID:0000-0002-3472-1389), Calvani R. (ORCID:0000-0001-5472-2365), Tosato M., Marzetti E. (ORCID:0000-0001-9567-6983), Bernabei, Roberto, Landi, Francesco, Calvani, Riccardo, Cesari, M., Del Signore, S., Anker, S. D., Bejuit, R., Bordes, P., Cherubini, A., Cruz-Jentoft, A. J., Di Bari, M., Friede, T., Ayestaran, C. G., Goyeau, H., Jonsson, P. V., Kashiwa, M., Lattanzio, F., Maggio, M., Mariotti, L., Miller, R. R., Rodriguez-Manas, L., Roller-Wirnsberger, R., Ryznarova, I., Scholpp, J., Schols, A. M. W. J., Sieber, C. C., Sinclair, A. J., Skalska, A., Strandberg, T., Tchalla, A., Topinkova, E., Tosato, Matteo, Vellas, B., Von Haehling, S., Pahor, M., Roubenoff, R., Marzetti, Emanuele, Bernabei R. (ORCID:0000-0002-9197-004X), Landi F. (ORCID:0000-0002-3472-1389), Calvani R. (ORCID:0000-0001-5472-2365), Tosato M., and Marzetti E. (ORCID:0000-0001-9567-6983)
- Abstract
Objective To determine whether a multicomponent intervention based on physical activity with technological support and nutritional counselling prevents mobility disability in older adults with physical frailty and sarcopenia. Design Evaluator blinded, randomised controlled trial. Setting 16 clinical sites across 11 European countries, January 2016 to 31 October 2019. Participants 1519 community dwelling men and women aged 70 years or older with physical frailty and sarcopenia, operationalised as the co-occurrence of low functional status, defined as a short physical performance battery (SPPB) score of 3 to 9, low appendicular lean mass, and ability to independently walk 400 m. 760 participants were randomised to a multicomponent intervention and 759 received education on healthy ageing (controls). Interventions The multicomponent intervention comprised moderate intensity physical activity twice weekly at a centre and up to four times weekly at home. Actimetry data were used to tailor the intervention. Participants also received personalised nutritional counselling. Control participants received education on healthy ageing once a month. Interventions and follow-up lasted for up to 36 months. Main outcome measures The primary outcome was mobility disability (inability to independently walk 400 m in <15 minutes). Persistent mobility disability (inability to walk 400 m on two consecutive occasions) and changes from baseline to 24 and 36 months in physical performance, muscle strength, and appendicular lean mass were analysed as pre-planned secondary outcomes. Primary comparisons were conducted in participants with baseline SPPB scores of 3-7 (n=1205). Those with SPPB scores of 8 or 9 (n=314) were analysed separately for exploratory purposes. Results Mean age of the 1519 participants (1088 women) was 78.9 (standard deviation 5.8) years. The average follow-up was 26.4 (SD 9.5) months. Among participants with SPPB scores of 3-7, mobility disability occurred in 283/605 (
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- 2022
6. The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans
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Jyvakorpi S. K., Ramel A., Strandberg T. E., Piotrowicz K., Blaszczyk-Bebenek E., Urtamo A., Rempe H. M., Geirsdottir O., Vagnerova T., Billot M., Larreur A., Savera G., Soriano G., Picauron C., Tagliaferri S., Sanchez-Puelles C., Cadenas V. S., Perl A., Tirrel L., Ohman H., Weling-Scheepers C., Ambrosi S., Costantini A., Pavelkova K., Klimkova M., Freiberger E., Jonsson P. V., Marzetti E., Pitkala K. H., Landi F., Calvani R., Bernabei R., Boni C., Brandi V., Broccatelli M., Celesti C., Cicchetti A., Collamati A., Coretti S., D'Angelo E., D'Elia M., Landi G., Lorenzi M., Mariotti L., Martone A. M., Ortolani E., Pafundi T., Picca A., Ruggeri M., Salini S., Tosato M., Vetrano D. L., Lattanzio F., Baldoni R., Bernabei S., Bonfigli A. R., Bustacchini S., Carrieri B., Cassetta L., Cherubini A., Cucchi M., Cucchieri G., Costantini A. R., Dell'Aquila G., Espinosa E., Fedecostante M., Fraternali R., Galeazzi R., Mengarelli A., Piomboni S., Posacki E., Severini E., Tregambe T., Trotta F., Maggio M., Lauretani F., Butto V., Fisichella A., Guareschi C., Longobucco Y., Di Bari M., Rodriguez-Manas L., Alamo S., Bouzon C. A., Gonzales Turin J., Zafra O. L. L., Picazo A. L., Sepulveda L. P., SanchezSanchez J. L., Puelles C. S., Aragones M. V., CruzJentoft A. J., Santos J. A., Alvarez-Nebreda L., JimenezJimenez N. F., Nozal J. M. -D., Montero-Errasquin B., Moreno B. P. B. P., Roldan-Plaza C., Vicente A. R. -D., Sanchez-Cadenas V., Sanchez-Castellano C., Sanchez-Garcia E., Vaquero-Pinto M. N., Topinkova E., Bautzka L., Blechova K., Gueye T., Juklickova I., Klbikova T., Krenkova J. J., Madlova P., Mejstrikova H., Melcova R., Michalkova H., Ryznarova I., Drastichova I., Hasalikova E., Hucko R., Jakub S., Janacova M., Kilmkova M., Parizkova M., Redrova M., Ruskova P. P., Sieber C. C., Auerswald T., Engel C., Franke A., Freibergen E., Freiheit U., Gotthardt S., Kampe K., Kob R., Kokott C., Kraska C., Meyer C., Reith V., Rempe H., Schoene D., Sieber G., Zielinski K., Anker S. D., Ebner N., Grutz R., von Haehling S., Schols A. M. W. J., Gosker H., Huysmans S., Quaaden S., Schols J. M., Smeets N., Stevens P., van de Bool C., Weling C., Strandberg T., Jyvakorpi S., Hallikas K., Herranen M., Huusko T., Hytonen L., Ikonen K., Karppi-Sjoblom A., Karvinen K., Kayhty M., Kindsted T., Landstrom E., Leirimaa S., Pitkala K., Punkka A., Saavalainen A. -M., Salo T., Sepa M., Sohlberg K., Vaatamoinen E., Venalainen S., Vanhanen H., Vellas B., Van Kan G. A., Biville V., Brigitte L., Cervera C., Cesari M., Champarnaud M., Cluzan C., Croizet M., Dardenne S., Dorard M., Dupuy C., Durand E., Faisant C., Fougere B., Girard P., Guyonnet S., Hoogendijk E., Mauroux R., Milhet A., Montel S., Ousset P. -J., Teguo M. T., Teysseyre B., Andrieu S., Blasimme A., Dray C., Rial-Sebbag E., Valet P., Dantoine T., Cardinaud N., Castelli M., Charenton-Blavignac M., Ciccolari-Micaldi C., Gayot C., Laubarie-Mouriet C., Marchesseau D., Mergans T., Nguyen T. B., Papon A., Ribet J., Saulinier I., Tchalla A., Rapp T., Sirven N., Skalska A., Blaszcyk E., Cwynar M., Czesak J., Fatyga P., Fedyk-Lukasik M., Grodzicki T., Jamrozik P., Janusz Z., Klimek E., Komoniewska S., Kret M., Ozog M., Parnicka A., Petitjean K., Pietrzyk A., Skalska-Dulinska B., Starzyk D., Szczerbinska K., Witkiewicz B., Wlodarczyk A., Sinclair A., Harris S., Ogborne A., Ritchie S., Sinclair C., Sinclair H., Bellary S., Worthington H., Derejczyk J., Roller-Wirnsberger R., Jonsson P., Bordes P., Arnaud S., Asbrand C., Bejuit R., Durand S., Flechsenhar K., Joly F., Lain R. L., Moncharmont M., Msihid J., Ndja A., Riche B., Weber A. C., Yuan J., Roubenoff R., Kortebein P., Miller R. R., Gorostiaga C., Belissa-Mathiot P., Hu H., Laigle L., Melchor I. M., Russel A., Bennecky M., Haws T., Joshi A., Philpott K., Walker A., Zia G., Giorgi S. D., Feletti L., Marchioro E., Mocci F., Varesio M. G., Cesario A., Cabin B., de Boer W. P., Ignaszewski C., Klingmann I., Vollenbroek-Hutten M., Hermens T., Jansen-Kosterink S., Tabak M., Blandin P., Coutard L., Lenzotti A. -M., Mokhtari H., Rodon N., RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, Handicap, Activité, Vieillissement, Autonomie, Environnement (HAVAE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Clinicum, Department of General Practice and Primary Health Care, University of Helsinki, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Helsinki University Hospital Area, Teachers' Academy, Jyvakorpi S.K., Ramel A., Strandberg T.E., Piotrowicz K., Blaszczyk-Bebenek E., Urtamo A., Rempe H.M., Geirsdottir O., Vagnerova T., Billot M., Larreur A., Savera G., Soriano G., Picauron C., Tagliaferri S., Sanchez-Puelles C., Cadenas V.S., Perl A., Tirrel L., Ohman H., Weling-Scheepers C., Ambrosi S., Costantini A., Pavelkova K., Klimkova M., Freiberger E., Jonsson P.V., Marzetti E., Pitkala K.H., Landi F., Calvani R., Bernabei R., Boni C., Brandi V., Broccatelli M., Celesti C., Cicchetti A., Collamati A., Coretti S., D'Angelo E., D'Elia M., Landi G., Lorenzi M., Mariotti L., Martone A.M., Ortolani E., Pafundi T., Picca A., Ruggeri M., Salini S., Tosato M., Vetrano D.L., Lattanzio F., Baldoni R., Bernabei S., Bonfigli A.R., Bustacchini S., Carrieri B., Cassetta L., Cherubini A., Cucchi M., Cucchieri G., Costantini A.R., Dell'Aquila G., Espinosa E., Fedecostante M., Fraternali R., Galeazzi R., Mengarelli A., Piomboni S., Posacki E., Severini E., Tregambe T., Trotta F., Maggio M., Lauretani F., Butto V., Fisichella A., Guareschi C., Longobucco Y., Di Bari M., Rodriguez-Manas L., Alamo S., Bouzon C.A., Gonzales Turin J., Zafra O.L.L., Picazo A.L., Sepulveda L.P., SanchezSanchez J.L., Puelles C.S., Aragones M.V., CruzJentoft A.J., Santos J.A., Alvarez-Nebreda L., JimenezJimenez N.F., Nozal J.M.-D., Montero-Errasquin B., Moreno B.P.B.P., Roldan-Plaza C., Vicente A.R.-D., Sanchez-Cadenas V., Sanchez-Castellano C., Sanchez-Garcia E., Vaquero-Pinto M.N., Topinkova E., Bautzka L., Blechova K., Gueye T., Juklickova I., Klbikova T., Krenkova J.J., Madlova P., Mejstrikova H., Melcova R., Michalkova H., Ryznarova I., Drastichova I., Hasalikova E., Hucko R., Jakub S., Janacova M., Kilmkova M., Parizkova M., Redrova M., Ruskova P.P., Sieber C.C., Auerswald T., Engel C., Franke A., Freibergen E., Freiheit U., Gotthardt S., Kampe K., Kob R., Kokott C., Kraska C., Meyer C., Reith V., Rempe H., Schoene D., Sieber G., Zielinski K., Anker S.D., Ebner N., Grutz R., von Haehling S., Schols A.M.W.J., Gosker H., Huysmans S., Quaaden S., Schols J.M., Smeets N., Stevens P., van de Bool C., Weling C., Strandberg T., Jyvakorpi S., Hallikas K., Herranen M., Huusko T., Hytonen L., Ikonen K., Karppi-Sjoblom A., Karvinen K., Kayhty M., Kindsted T., Landstrom E., Leirimaa S., Pitkala K., Punkka A., Saavalainen A.-M., Salo T., Sepa M., Sohlberg K., Vaatamoinen E., Venalainen S., Vanhanen H., Vellas B., Van Kan G.A., Biville V., Brigitte L., Cervera C., Cesari M., Champarnaud M., Cluzan C., Croizet M., Dardenne S., Dorard M., Dupuy C., Durand E., Faisant C., Fougere B., Girard P., Guyonnet S., Hoogendijk E., Mauroux R., Milhet A., Montel S., Ousset P.-J., Teguo M.T., Teysseyre B., Andrieu S., Blasimme A., Dray C., Rial-Sebbag E., Valet P., Dantoine T., Cardinaud N., Castelli M., Charenton-Blavignac M., Ciccolari-Micaldi C., Gayot C., Laubarie-Mouriet C., Marchesseau D., Mergans T., Nguyen T.B., Papon A., Ribet J., Saulinier I., Tchalla A., Rapp T., Sirven N., Skalska A., Blaszcyk E., Cwynar M., Czesak J., Fatyga P., Fedyk-Lukasik M., Grodzicki T., Jamrozik P., Janusz Z., Klimek E., Komoniewska S., Kret M., Ozog M., Parnicka A., Petitjean K., Pietrzyk A., Skalska-Dulinska B., Starzyk D., Szczerbinska K., Witkiewicz B., Wlodarczyk A., Sinclair A., Harris S., Ogborne A., Ritchie S., Sinclair C., Sinclair H., Bellary S., Worthington H., Derejczyk J., Roller-Wirnsberger R., Jonsson P., Bordes P., Arnaud S., Asbrand C., Bejuit R., Durand S., Flechsenhar K., Joly F., Lain R.L., Moncharmont M., Msihid J., Ndja A., Riche B., Weber A.C., Yuan J., Roubenoff R., Kortebein P., Miller R.R., Gorostiaga C., Belissa-Mathiot P., Hu H., Laigle L., Melchor I.M., Russel A., Bennecky M., Haws T., Joshi A., Philpott K., Walker A., Zia G., Giorgi S.D., Feletti L., Marchioro E., Mocci F., Varesio M.G., Cesario A., Cabin B., de Boer W.P., Ignaszewski C., Klingmann I., Vollenbroek-Hutten M., Hermens T., Jansen-Kosterink S., Tabak M., Blandin P., Coutard L., Lenzotti A.-M., Mokhtari H., Rodon N., Epidemiology and Data Science, APH - Aging & Later Life, and APH - Quality of Care
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0301 basic medicine ,Gerontology ,Sarcopenia ,[SDV]Life Sciences [q-bio] ,Population ,PROTEIN ,RECOMMENDATIONS ,law.invention ,SUPPLEMENTATION ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Intervention (counseling) ,Cultural diversity ,medicine ,Nutrition counselling ,Nutrition intervention ,Humans ,030212 general & internal medicine ,Medical prescription ,education ,Exercise ,Aged ,2. Zero hunger ,education.field_of_study ,030109 nutrition & dietetics ,Frailty ,business.industry ,Settore MED/09 - MEDICINA INTERNA ,ADULTS ,medicine.disease ,mobility ,3. Good health ,Feasibility Studie ,Malnutrition ,SPRINTT ,resistance exercise ,muscle mass ,Protein intake ,3121 General medicine, internal medicine and other clinical medicine ,Feasibility Studies ,Energy intake ,Independent Living ,business ,Nutrition counseling ,Research Paper ,Human - Abstract
Aim To describe the methods and feasibility of the nutritional intervention carried out within the SPRINTT Randomized cotrolled trial. We also illustrate how nutrition interventionists identified participants at risk of malnutrition and the lessons learnt from the nutrition intervention. Findings SPRINTT nutrition intervention was well-received by the majority of the participants. It was mainly carried out using tailored nutrition counselling, but also other means of delivering the intervention were successfully used. Compared with a standard nutrition prescription, an individualized protocol to diagnose malnutrition and follow-up by tailored nutrition counselling helped achieve nutritional targets more effectively in spite of diversity of population in nutritional habits and in some cases reluctance to accept changes. Message The SPRINTT nutrition intervention was feasible and allowed flexibility to the varying needs and cultural differences of this heterogeneous population of frail, older Europeans. It may serve as a model to educate and improve nutrition among community-dwelling older people at risk of mobility limitations. Supplementary Information The online version contains supplementary material available at 10.1007/s41999-020-00438-4., Background The “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) project sponsored a multi-center randomized controlled trial (RCT) with the objective to determine the effect of physical activity and nutrition intervention for prevention of mobility disability in community-dwelling frail older Europeans. We describe here the design and feasibility of the SPRINTT nutrition intervention, including techniques used by nutrition interventionists to identify those at risk of malnutrition and to carry out the nutrition intervention. Methods SPRINTT RCT recruited older adults (≥ 70 years) from 11 European countries. Eligible participants (n = 1517) had functional limitations measured with Short Physical Performance Battery (SPPB score 3–9) and low muscle mass as determined by DXA scans, but were able to walk 400 m without assistance within 15 min. Participants were followed up for up to 3 years. The nutrition intervention was carried out mainly by individual nutrition counseling. Nutrition goals included achieving a daily protein intake of 1.0–1.2 g/kg body weight, energy intake of 25–30 kcal/kg of body weight/day, and serum vitamin D concentration ≥ 75 mmol/L. Survey on the method strategies and feasibility of the nutrition intervention was sent to all nutrition interventionists of the 16 SPRINTT study sites. Results Nutrition interventionists from all study sites responded to the survey. All responders found that the SPRINTT nutrition intervention was feasible for the target population, and it was well received by the majority. The identification of participants at nutritional risk was accomplished by combining information from interviews, questionnaires, clinical and laboratory data. Although the nutrition intervention was mainly carried out using individual nutritional counselling, other assisting methods were used as appropriate. Conclusion The SPRINTT nutrition intervention was feasible and able to adapt flexibly to varying needs of this heterogeneous population. The procedures adopted to identify older adults at risk of malnutrition and to design the appropriate intervention may serve as a model to deliver nutrition intervention for community-dwelling older people with mobility limitations. Supplementary Information The online version contains supplementary material available at 10.1007/s41999-020-00438-4.
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- 2021
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7. Promoting access to innovation for frail old persons: IAGG (International Association of Gerontology and Geriatrics), WHO (World Health Organization) and SFGG (Societe Francaise de Geriatrie et de Gerontologie) workshop — Athens January 20–21, 2012
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Berrut, G., Andrieu, S., Araujo De Carvalho, I., Baeyens, J. P., Bergman, H., Cassim, B., Cerreta, F., Cesari, M., Cha, H. B., Chen, L. K., Cherubini, A., Chou, M. Y., Cruz-Jentoft, A. J., De Decker, L., Du, P., Forette, B., Forette, F., Franco, A., Guimaraes, R., Gutierrez-Robledo, L. M., Jauregui, J., Khavinson, V., Lee, W. J., Peng, L. N., Perret-Guillaume, C., Petrovic, M., Retornaz, F., Rockwood, K., Rodriguez-Manas, L., Sieber, C., Spatharakis, G., Theou, O., Topinkova, E., Vellas, B., and Benetos, Athanase
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- 2013
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8. Nutrition in the age-related disablement process
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Inzitari, Marco, Doets, E., Bartali, B., Benetou, V., Di Bari, M., Visser, M., Volpato, S., Gambassi, G., Topinkova, E., De Groot, L., Salva, A., and For the International Association of Gerontology and Geriatrics (IAGG) Task Force for Nutrition in the Elderly
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- 2011
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9. Using the Multidimensional Prognostic Index to Predict Clinical Outcomes of Hospitalized Older Persons: A Prospective, Multicenter, International Study
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Pilotto, A, Veronese, N, Daragjati, J, Cruz-Jentoft, AJ, Polidori, MC, Mattace Raso, F.U.S., Paccalin, M, Topinkova, E, Siri, G, Greco, A, Mangoni, AA, Maggi, S, Ferrucci, L, Musacchio, C, Custureri, R, Simonato, M, Durando, M, Miret-Corchado, C, Montero-Errasquin, B, Meyer, A, Hoffmann, D, Schulz, RJ, Tap, Lisanne, Egberts, A, Bureau, ML, Brunet, T, Liuu, E, Michalkova, H, Madlova, P, Sancarlo, D, D'Onofrio, G, Ruxton, K, Internal Medicine, Erasmus MC other, Pilotto, A., Veronese, N., Daragjati, J., Cruz-Jentoft, A.J., Polidori, M.C., Mattace-Raso, F., Paccalin, M., Topinkova, E., Siri, G., Greco, A., Mangoni, A.A., Maggi, S., Ferrucci, L., and MPI_AGE Investigators
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Male ,Aging ,medicine.medical_specialty ,Longitudinal study ,Index (economics) ,Institutionalisation ,Prognosi ,030204 cardiovascular system & hematology ,Risk Assessment ,03 medical and health sciences ,Hospital ,0302 clinical medicine ,Predictive Value of Tests ,Multidimensional Prognostic Index ,medicine ,Risk of mortality ,Humans ,Longitudinal Studies ,Prospective Studies ,030212 general & internal medicine ,Geriatric Assessment ,Aged ,Aged, 80 and over ,business.industry ,Australia ,Retrospective cohort study ,Odds ratio ,Prognosis ,Europe ,Hospitalization ,ROC Curve ,The Journal of Gerontology: Medical Sciences ,Emergency medicine ,Cohort ,Female ,Geriatrics and Gerontology ,business ,Cohort study - Abstract
Background Multidimensional Prognostic Index (MPI) is useful as a prognostic tool in hospitalized older patients, but our knowledge is derived from retrospective studies. We therefore aimed to evaluate in a multicenter, longitudinal, cohort study whether the MPI at hospital admission is useful to identify groups with different mortality risk and whether MPI at discharge may predict institutionalization, rehospitalization, and use of home care services during 12 months. Methods This longitudinal study, carried out between February 2015 and August 2017, included nine public hospitals in Europe and Australia. A standardized comprehensive geriatric assessment including information on functional, nutritional, cognitive status, risk of pressure sores, comorbidities, medications, and cohabitation status was used to calculate the MPI and to categorize participants in low, moderate, and severe risk of mortality. Data regarding mortality, institutionalization, rehospitalization, and use of home care services were recorded through administrative information. Results Altogether, 1,140 hospitalized patients (mean age 84.1 years, women = 60.8%) were included. In the multivariable analysis, compared to patients with low risk group at admission, patients in moderate (odds ratio [OR] = 3.32; 95% CI: 1.79–6.17; p < .001) and severe risk (OR = 10.72, 95% CI: 5.70–20.18, p < .0001) groups were at higher risk of overall mortality. Among the 984 older patients with follow-up data available, those in the severe-risk group experienced a higher risk of overall mortality, institutionalization, rehospitalization, and access to home care services. Conclusions In this cohort of hospitalized older adults, higher MPI values are associated with higher mortality and other negative outcomes. Multidimensional assessment of older people admitted to hospital may facilitate appropriate clinical and postdischarge management.
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- 2019
10. Unintended weight loss in the elderly living at home: The aged in home care project (ADHOC)
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Sørbye, L. W., Schroll, M., Finne-Soveri, H., Jonsson, P. V., Topinkova, E., Ljunggren, G., Bernabei, R., and For ADHOC Project Research Group
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- 2008
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11. Using the Multidimensional Prognostic Index (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons: results and final recommendations from the MPI_AGE European Project
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Cruz-Jentoft, A. J., Daragjati, J., Fratiglioni, L., Maggi, S., Mangoni, A. A., Mattace-Raso, F., Paccalin, M., Polidori, M. C., Topinkova, E., Ferrucci, L., Pilotto, A., Angleman, S. B., Bureau, M. -L., Brunet, T., Cella, A., Custodero, C., Custureri, R., Egberts, A., Durando, M., Ferri, A., Gallina, P., Hoffmann, D., Liuu, E., Madlova, P., Meyer, A., Michalkova, H., Miret-Corchado, C., Montero-Errasquin, B., Musacchio, C., Puntoni, M., Ruxton, K., Sabba, C., Santoni, G., Schulz, R. -J., Simonato, M., Siri, G., Sultana, J., Tap, L., Trifiro, G., Welmer, A. -K., and Internal Medicine
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Male ,Aging ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,Frail Elderly ,Population ,Psychological intervention ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Multidimensional Prognostic Index ,Risk Factors ,Health care ,Medicine ,media_common.cataloged_instance ,Humans ,030212 general & internal medicine ,Prospective Studies ,European union ,Cognitive decline ,Intensive care medicine ,education ,Comprehensive Geriatric Assessment ,Frailty ,MPI_AGE ,Multimorbidity ,Geriatric Assessment ,media_common ,Aged ,Geriatrics ,Aged, 80 and over ,education.field_of_study ,business.industry ,medicine.disease ,Prognosis ,Hospitalization ,Female ,Independent Living ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series of international studies performed in different settings have shown that the MPI is useful to predict mortality and risk of hospitalization in community-dwelling older subjects at population level. Furthermore, studies performed in older people who underwent a CGA before admission to a nursing home or receiving homecare services showed that the MPI successfully identified groups of persons who could benefit, in terms of reduced mortality, of specific therapies such as statins in diabetes mellitus and coronary artery disease, anticoagulants in atrial fibrillation and antidementia drugs in cognitive decline. A prospective trial carried out in nine hospitals in Europe and Australia demonstrated that the MPI was able to predict not only in-hospital and long-term mortality, but also institutionalization, re-hospitalization and receiving homecare services during the one-year follow-up after hospital discharge. The project also explored the association between MPI and mortality in hospitalized older patients in need of complex procedures such as transcatheter aortic valve implantation or enteral tube feeding. Evidence from these studies has prompted the MPI_AGE Investigators to formulate recommendations for healthcare providers, policy makers and the general population which may help to improve the cost-effectiveness of appropriate health care interventions for older patients.
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- 2020
12. Deprescribing tool for STOPPFall (screening tool of older persons prescriptions in older adults with high fall risk) items
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Seppala, L. J., Petrovic, M., Jesper Ryg, Bahat, G., Topinkova, E., Szczerbińska, K., Cammen, T. J., Hartikainen, S., Ilhan, B., Landi, F., Morrissey, Y., Mair, A., Gutiérrez-Valencia, M., Emmelot-Vonk, M. H., Caballero Mora, M. A., Michael Denkinger, Crome, P., Jackson, S. H. D., Correa-Pérez, A., Knol, W., Soulis, G., Adalsteinn Gudmundsson, Ziere, G., Wehling, M., O’mahony, D., Antonio Cherubini, and Nathalie van der Velde
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screening ,fall risk ,Medicine and Health Sciences ,Deprescribing tool ,older persons prescriptions ,STOPPFall - Abstract
Background: Health care professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier. To support clinicians in the management of FRIDs and to facilitate the deprescribing process, a deprescribing tool was developed by a European expert group for STOPPFall (Screening Tool of Older Persons Prescriptions in older adults with high fall risk) items. Methods: STOPPFall was created using an expert Delphi consensus process in 2019 and in 2020, 24 panellists from EuGMS SIG on Pharmacology and Task and Finish on FRIDs completed deprescribing tool questionnaire. To develop the questionnaire, a Medline literature search was performed. The panellists were asked to indicate for every medication class a possible need for stepwise withdrawal and strategy for withdrawal. They were asked in which situations withdrawal should be performed. Furthermore, panellists were requested to indicate those symptoms patients should be monitored for after deprescribing and a possible need for follow-ups. Results: Practical deprescribing guidance was developed for STOPPFall medication classes. For each medication class, a decision tree algorithm was developed including steps from medication review to symptom monitoring after medication withdrawal. Conclusion: STOPPFall was combined with a practical deprescribing tool designed to optimize medication review. This practical guide can help overcome current reluctance towards deprescribing in clinical practice by providing an up-to-date and straightforward source of expert knowledge.
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- 2020
13. Preserving mobility in older adults with physical frailty and sarcopenia:opportunities, challenges, and recommendations for physical activity interventions
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Billot, M. (Maxime), Calvani, R. (Riccardo), Urtamo, A. (Annele), Sánchez-Sánchez, J. L. (Juan Luis), Ciccolari-Micaldi, C. (Cecilia), Chang, M. (Milan), Roller-Wirnsberger, R. (Regina), Wirnsberger, G. (Gerhard), Sinclair, A. (Alan), Vaquero-Pinto, N. (Nieves), Jyväkorpi, S. (Satu), Öhman, H. (Hanna), Strandberg, T. (Timo), Schols, J. M. (Jos M. G. A), Schols, A. M. (Annemie M. W. J), Smeets, N. (Nick), Topinkova, E. (Eva), Michalkova, H. (Helena), Bonfigli, A. R. (Anna Rita), Lattanzio, F. (Fabrizia), Rodríguez-Mañas, L. (Leocadio), Coelho-Júnior, H. (Hélio), Broccatelli, M. (Marianna), D’Elia, M. E. (Maria Elena), Biscotti, D. (Damiano), Marzetti, E. (Emanuele), and Freiberger, E. (Ellen)
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walking ,better aging ,muscle mass ,physical exercise ,balance ,strength - Abstract
One of the most widely conserved hallmarks of aging is a decline in functional capabilities. Mobility loss is particularly burdensome due to its association with negative health outcomes, loss of independence and disability, and the heavy impact on quality of life. Recently, a new condition, physical frailty and sarcopenia, has been proposed to define a critical stage in the disabling cascade. Physical frailty and sarcopenia are characterized by weakness, slowness, and reduced muscle mass, yet with preserved ability to move independently. One of the strategies that have shown some benefits in combatting mobility loss and its consequences for older adults is physical activity. Here, we describe the opportunities and challenges for the development of physical activity interventions in people with physical frailty and sarcopenia. The aim of this article is to review age-related physio(patho)logical changes that impact mobility in old age and to provide recommendations and procedures in accordance with the available literature.
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- 2020
14. STOPPFall (Screening Tool of Older Persons Prescriptions in older adults with high fall risk): a Delphi study by the EuGMS Task and Finish Group on Fall-Risk-Increasing Drugs
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Seppala, L.J. (author), Petrovic, Mirko (author), Ryg, J. (author), Bahat, G. (author), Topinkova, E. (author), Szczerbińska, K. (author), van der Cammen, T.J.M. (author), Hartikainen, S. (author), Ilhan, B. (author), Seppala, L.J. (author), Petrovic, Mirko (author), Ryg, J. (author), Bahat, G. (author), Topinkova, E. (author), Szczerbińska, K. (author), van der Cammen, T.J.M. (author), Hartikainen, S. (author), and Ilhan, B. (author)
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BACKGROUND: Healthcare professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier and furthermore, there is no consensus on which medications are considered as FRIDs despite several systematic reviews. To support clinicians in the management of FRIDs and to facilitate the deprescribing process, STOPPFall (Screening Tool of Older Persons Prescriptions in older adults with high fall risk) and a deprescribing tool were developed by a European expert group. METHODS: STOPPFall was created by two facilitators based on evidence from recent meta-analyses and national fall prevention guidelines in Europe. Twenty-four panellists chose their level of agreement on a Likert scale with the items in the STOPPFall in three Delphi panel rounds. A threshold of 70% was selected for consensus a priori. The panellists were asked whether some agents are more fall-risk-increasing than others within the same pharmacological class. In an additional questionnaire, panellists were asked in which cases deprescribing of FRIDs should be considered and how it should be performed. RESULTS: The panellists agreed on 14 medication classes to be included in the STOPPFall. They were mostly psychotropic medications. The panellists indicated 18 differences between pharmacological subclasses with regard to fall-risk-increasing properties. Practical deprescribing guidance was developed for STOPPFall medication classes. CONCLUSION: STOPPFall was created using an expert Delphi consensus process and combined with a practical deprescribing tool designed to optimise medication review. The effectiveness of these tools in falls prevention should be further evaluated in intervention studies., Applied Ergonomics and Design
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- 2020
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15. Use of antidepressant medications among older adults in European long-term care facilities: a cross-sectional analysis from the SHELTER study
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Giovannini, Silvia, Onder, Graziano, van der Roest, Hg, Topinkova, E, Gindin, J, Cipriani, Maria Camilla, Denkinger, Md, Bernabei, Roberto, Liperoti, Rosa, Giovannini S (ORCID:0000-0001-9125-752X), Onder G (ORCID:0000-0003-3400-4491), Cipriani MC, Bernabei R (ORCID:0000-0002-9197-004X), Liperoti R (ORCID:0000-0003-3740-1687), Giovannini, Silvia, Onder, Graziano, van der Roest, Hg, Topinkova, E, Gindin, J, Cipriani, Maria Camilla, Denkinger, Md, Bernabei, Roberto, Liperoti, Rosa, Giovannini S (ORCID:0000-0001-9125-752X), Onder G (ORCID:0000-0003-3400-4491), Cipriani MC, Bernabei R (ORCID:0000-0002-9197-004X), and Liperoti R (ORCID:0000-0003-3740-1687)
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Background: Late-life depression is common among older adults living in nursing homes (NHs). Over the last 30 years there has been an increase in the rates of prescription of antidepressant medications across all ages, with the largest rise reported in older adults. This study aimed to describe the pattern of antidepressant medication use among NH residents from 7 European countries and Israel and to examine patient and facilities characteristics that may account for it. Methods: We conducted a cross-sectional analysis of data from the SHELTER study, an observational longitudinal cohort study that collected comprehensive resident data using the interRAI Long-Term Care Facility instrument in 7 European Countries and Israel. Descriptive statistics were used to examine sample characteristics. Potential correlates of antidepressant medication use were identified using multiple logistic regression modeling. Results: Among 4023 residents entering the study, 32% had depressive symptoms and nearly half of these individuals used antidepressants. Antidepressant medication use varied by country, with a prevalence in the overall sample of 35.6% (n = 1431). Among antidepressant users, 59.9% were receiving selective serotonin reuptake inhibitors (SSRI). The strongest correlates of antidepressant use included reported diagnosis of anxiety, depression, bipolar disorder, pain, falls and high level of social engagement. Age over 85 years, living in facilities located in rural areas and a diagnosis of schizophrenia reduced the likelihood of being prescribed with an antidepressant. Conclusions: A large proportion of residents in European long-term care facilities receive antidepressant medications. The decision to prescribe antidepressants to NH residents seems to be influenced by both patient and facility characteristics. Future longitudinal studies should evaluate the efficacy and safety of antidepressant use in NHs thus providing evidence for recommendations for clinical practice.
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- 2020
16. Preserving mobility in older adults with physical frailty and sarcopenia: Opportunities, challenges, and recommendations for physical activity interventions
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Billot, M., Calvani, R., Urtamo, A., Sanchez-Sanchez, J. L., Ciccolari-Micaldi, C., Chang, M., Roller-Wirnsberger, R., Wirnsberger, G., Sinclair, A., Vaquero-Pinto, N., Jyvakorpi, S., Ohman, H., Strandberg, T., Schols, J. M. G. A., Schols, A. M. W. J., Smeets, N., Topinkova, E., Michalkova, H., Bonfigli, A. R., Lattanzio, F., Rodriguez-Manas, L., Coelho-Junior, H., Broccatelli, M., D'elia, M. E., Biscotti, D., Marzetti, E., Freiberger, E., Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Billot, M., Calvani, R., Urtamo, A., Sanchez-Sanchez, J. L., Ciccolari-Micaldi, C., Chang, M., Roller-Wirnsberger, R., Wirnsberger, G., Sinclair, A., Vaquero-Pinto, N., Jyvakorpi, S., Ohman, H., Strandberg, T., Schols, J. M. G. A., Schols, A. M. W. J., Smeets, N., Topinkova, E., Michalkova, H., Bonfigli, A. R., Lattanzio, F., Rodriguez-Manas, L., Coelho-Junior, H., Broccatelli, M., D'elia, M. E., Biscotti, D., Marzetti, E., Freiberger, E., Calvani R. (ORCID:0000-0001-5472-2365), and Marzetti E. (ORCID:0000-0001-9567-6983)
- Abstract
One of the most widely conserved hallmarks of aging is a decline in functional capabilities. Mobility loss is particularly burdensome due to its association with negative health outcomes, loss of independence and disability, and the heavy impact on quality of life. Recently, a new condition, physical frailty and sarcopenia, has been proposed to define a critical stage in the disabling cascade. Physical frailty and sarcopenia are characterized by weakness, slowness, and reduced muscle mass, yet with preserved ability to move indepen-dently. One of the strategies that have shown some benefits in combatting mobility loss and its consequences for older adults is physical activity. Here, we describe the opportunities and challenges for the development of physical activity interventions in people with physical frailty and sarcopenia. The aim of this article is to review age-related physio(patho)logical changes that impact mobility in old age and to provide recommendations and procedures in accordance with the available literature.
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- 2020
17. Association of Antidementia Drugs and Mortality in Community-Dwelling Frail Older Patients With Dementia: The Role of Mortality Risk Assessment
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Pilotto, A., Polidori, M. C., Veronese, N., Panza, F., Arboretti Giancristofaro, R., Daragjati, J., Carrozzo, E., Prete, C., Gallina, P., Padovani, A., Maggi, S., Cruz-Jentoft, A., Durando, M., Ferrucci, L., Fratiglioni, L., Mattace-Raso, F., Paccalin, M., Ruppe, G., Schulz, R. -J., Topinkova, E., Trifirò, G., Welmer, A. -K., Multidimensional Prognostic Index (MPI)_Age Project Investigators, Internal Medicine, Medical Informatics, Pilotto, A., Polidori, M.C., Veronese, N., Panza, F., Arboretti Giancristofaro, R., Daragjati, J., Carrozzo, E., Prete, C., Gallina, P., Padovani, A., Maggi, S., Cruz-Jentoft, A., Durando, M., Ferrucci, L., Fratiglioni, L., Mattace-Raso, F., Paccalin, M., Ruppe, G., Schulz, R.-J., Topinkova, E., Trifirò, G., Welmer, A.-K., and Multidimensional Prognostic Index (MPI)_Age Project Investigators
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Male ,Gerontology ,medicine.medical_specialty ,Frail Elderly ,Multidimensional assessment ,antidementia drug ,Lower risk ,Comprehensive geriatric assessment ,Risk Assessment ,Article ,03 medical and health sciences ,0302 clinical medicine ,Older patients ,SDG 3 - Good Health and Well-being ,Risk Factors ,antidementia drugs ,comprehensive geriatric assessment ,Dementia ,frailty ,mortality ,multidimensional prognostic index (MPI) ,Nursing (all)2901 Nursing (miscellaneous) ,Health Policy ,Geriatrics and Gerontology ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Multidimensional prognostic index (MPI) ,Mortality ,Geriatric Assessment ,General Nursing ,Aged ,Retrospective Studies ,Aged, 80 and over ,Frailty ,business.industry ,Hazard ratio ,General Medicine ,medicine.disease ,Survival Analysis ,Confidence interval ,Antidementia drugs ,Female ,Independent Living ,Nursing homes ,business ,Risk assessment ,030217 neurology & neurosurgery - Abstract
Objective: To evaluate whether treatment with antidementia drugs is associated with reduced mortality in older patients with different mortality risk at baseline. Design: Retrospective. Setting: Community-dwelling. Participants: A total of 6818 older people who underwent a Standardized Multidimensional Assessment Schedule for Adults and Aged Persons (SVaMA) evaluation to determine accessibility to homecare services or nursing home admission from 2005 to 2013 in the Padova Health District, Italy were included. Measurements: Mortality risk at baseline was calculated by the Multidimensional Prognostic Index (MPI), based on information collected with the SVaMA. Participants were categorized to have mild (MPI-SVaMA-1), moderate (MPI-SVaMA-2), and high (MPI-SVaMA-3) mortality risk. Propensity score-adjusted hazard ratios (HR) of 2-year mortality were calculated according to antidementia drug treatment. Results: Patients treated with antidementia drugs had a significant lower risk of death than untreated patients (HR 0.82; 95% confidence interval [CI] 0.73–0.92 and 0.56; 95% CI 0.49–0.65 for patients treated less than 2 years and more than 2 years treatment, respectively). After dividing patients according to their MPI-SVaMA grade, antidementia treatment was significantly associated with reduced mortality in the MPI-SVaMA-1 mild (HR 0.71; 95% CI 0.54–0.92) and MPI-SVaMA-2 moderate risk (HR 0.61; 95% CI 0.40–0.91, matched sample), but not in the MPI-SVaMA-3 high risk of death. Conclusions: This large community-dwelling patient study suggests that antidementia drugs might contribute to increased survival in older adults with dementia with lower mortality risk. © 2017 AMDA – The Society for Post-Acute and Long-Term Care Medicine
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- 2018
18. EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs) : Position on Knowledge Dissemination, Management, and Future Research
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Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., Szczerbinska, K., Hartikainen, S., Kenny, R. A., Ryg, J., Eklund, P., Topinkova, E., Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutierrez-Valencia, M., Caballero-Mora, M. A., Landi, F., Emmelot-Vonk, M. H., Cherubini, A., Baeyens, J. P., Correa-Perez, A., Gudmundsson, A., Marengoni, A., O'Mahony, D., Parekh, N., Pisa, F. E., Rajkumar, C., Wehling, M., Ziere, G., Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., Szczerbinska, K., Hartikainen, S., Kenny, R. A., Ryg, J., Eklund, P., Topinkova, E., Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutierrez-Valencia, M., Caballero-Mora, M. A., Landi, F., Emmelot-Vonk, M. H., Cherubini, A., Baeyens, J. P., Correa-Perez, A., Gudmundsson, A., Marengoni, A., O'Mahony, D., Parekh, N., Pisa, F. E., Rajkumar, C., Wehling, M., and Ziere, G.
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Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe. The EuGMS Task and Finish group is developing educational materials to facilitate knowledge dissemination for healthcare professionals and older people. In addition, steps in primary prevention through judicious prescribing, deprescribing of FRIDs (withdrawal and dose reduction), and gaps in current research are outlined in this position paper.
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- 2019
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19. European postgraduate curriculum in geriatric medicine developed using an international modified Delphi technique
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Roller-Wirnsberger, R., Masud, T., Vassallo, M., Zobl, M., Reiter, R., Van Den Noortgate, N., Petermans, J., Petrov, I., Topinkova, E., Andersen-Ranberg, K., Saks, K., Nuotio, M., Bonin-Guillaume, S., Luttje, D., Mestheneos, E., Szekacs, B., Jonsdottir, A.B., O'Neill, D., Cherubini, A., Macijauskiene, J., Leners, J.C., Fiorini, A., Iersel, M.B. van, Ranhoff, A.H., Kostka, T., Duque, S., Prada, G.I., Davidovic, Mladen, Krajcik, S., Kolsek, M., Del Nozal, J.M., Ekdahl, A.W., Munzer, T., Savas, S., Knight, P., Gordon, A., Singler, K., Roller-Wirnsberger, R., Masud, T., Vassallo, M., Zobl, M., Reiter, R., Van Den Noortgate, N., Petermans, J., Petrov, I., Topinkova, E., Andersen-Ranberg, K., Saks, K., Nuotio, M., Bonin-Guillaume, S., Luttje, D., Mestheneos, E., Szekacs, B., Jonsdottir, A.B., O'Neill, D., Cherubini, A., Macijauskiene, J., Leners, J.C., Fiorini, A., Iersel, M.B. van, Ranhoff, A.H., Kostka, T., Duque, S., Prada, G.I., Davidovic, Mladen, Krajcik, S., Kolsek, M., Del Nozal, J.M., Ekdahl, A.W., Munzer, T., Savas, S., Knight, P., Gordon, A., and Singler, K.
- Abstract
Contains fulltext : 208089.pdf (publisher's version ) (Open Access), BACKGROUND: the European Union of Medical Specialists (UEMS-GMS) recommendations for training in Geriatric Medicine were published in 1993. The practice of Geriatric Medicine has developed considerably since then and it has therefore become necessary to update these recommendations. METHODS: under the auspices of the UEMS-GMS, the European Geriatric Medicine Society (EuGMS) and the European Academy of Medicine of Ageing (EAMA), a group of experts, representing all member states of the respective bodies developed a new framework for education and training of specialists in Geriatric Medicine using a modified Delphi technique. Thirty-two expert panel members from 30 different countries participated in the process comprising three Delphi rounds for consensus. The process was led by five facilitators. RESULTS: the final recommendations include four different domains: 'General Considerations' on the structure and aim of the syllabus as well as quality indicators for training (6 sub-items), 'Knowledge in patient care' (36 sub-items), 'Additional Skills and Attitude required for a Geriatrician' (9 sub-items) and a domain on 'Assessment of postgraduate education: which items are important for the transnational comparison process' (1 item). CONCLUSION: the current publication describes the development of the new recommendations endorsed by UEMS-GMS, EuGMS and EAMA as minimum training requirements to become a geriatrician at specialist level in EU member states.
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- 2019
20. EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research
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Seppala, L.J., van der Velde, N., Masud, T., Blain, H, Petrovic, M. (Mirko), Cammen, T.J.M. (Tischa) van der, Szczerbińska, K. (K.), Hartikainen, S. (Sirpa), Kenny, R.A., Ryg, J., Eklund, P., Topinkova, E, Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutierrez-Valencia, M., Caballero-Mora, M.A., Landi, F., Emmelot-Vonk, M.H., Cherubini, A. (Antonio), Baeyens, J.P., Correa-Perez, A., Gudmundsson, A., Marengoni, A., O'Mahony, D., Parekh, N., Pisa, F.E., Rajkumar, C. (Chakravarthi), Wehling, M., Ziere, G. (Gijsbertus), Seppala, L.J., van der Velde, N., Masud, T., Blain, H, Petrovic, M. (Mirko), Cammen, T.J.M. (Tischa) van der, Szczerbińska, K. (K.), Hartikainen, S. (Sirpa), Kenny, R.A., Ryg, J., Eklund, P., Topinkova, E, Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutierrez-Valencia, M., Caballero-Mora, M.A., Landi, F., Emmelot-Vonk, M.H., Cherubini, A. (Antonio), Baeyens, J.P., Correa-Perez, A., Gudmundsson, A., Marengoni, A., O'Mahony, D., Parekh, N., Pisa, F.E., Rajkumar, C. (Chakravarthi), Wehling, M., and Ziere, G. (Gijsbertus)
- Abstract
Falls are a major public health concern in the older population, and certain medication classes are a signifcant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe. The EuGMS Task and Finish group is developing educational materials to facilitate knowledge dissemination for healthcare professionals and older people. In addition, steps in primary prevention through judicious prescribing, deprescribing of FRIDs (withdrawal and dose reduction), and gaps in current research are outlined in this position paper.
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- 2019
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21. EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research
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MS Geriatrie, Circulatory Health, Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., Szczerbinska, K., Hartikainen, S., Kenny, R. A., Ryg, J., Eklund, P., Topinkova, E., Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutierrez-Valencia, M., Caballero-Mora, M. A., Landi, F., Emmelot-Vonk, M. H., Cherubini, A., Baeyens, J. P., Correa-Perez, A., Gudmundsson, A., Marengoni, A., O'Mahony, D., Parekh, N., Pisa, F. E., Rajkumar, C., Wehling, M., Ziere, G., MS Geriatrie, Circulatory Health, Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., Szczerbinska, K., Hartikainen, S., Kenny, R. A., Ryg, J., Eklund, P., Topinkova, E., Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutierrez-Valencia, M., Caballero-Mora, M. A., Landi, F., Emmelot-Vonk, M. H., Cherubini, A., Baeyens, J. P., Correa-Perez, A., Gudmundsson, A., Marengoni, A., O'Mahony, D., Parekh, N., Pisa, F. E., Rajkumar, C., Wehling, M., and Ziere, G.
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- 2019
22. EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research
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Seppala, LJ, Velde, N, Masud, T, Blain, H, Petrovic, M, van der Cammen, T.J.M., Szczerbinska, K, Hartikainen, S, Kenny, RA, Ryg, J, Eklund, P, Topinkova, E, Mair, A, Laflamme, L, Thaler, H, Bahat, G, Gutierrez-Valencia, M, Caballero-Mora, MA, Landi, F, Emmelot-Vonk, MH, Cherubini, A, Baeyens, JP, Correa-Perez, A, Gudmundsson, A, Marengoni, A, O'Mahony, D, Parekh, N, Pisa, FE, Rajkumar, C, Wehling, M, Ziere, Bert, Seppala, LJ, Velde, N, Masud, T, Blain, H, Petrovic, M, van der Cammen, T.J.M., Szczerbinska, K, Hartikainen, S, Kenny, RA, Ryg, J, Eklund, P, Topinkova, E, Mair, A, Laflamme, L, Thaler, H, Bahat, G, Gutierrez-Valencia, M, Caballero-Mora, MA, Landi, F, Emmelot-Vonk, MH, Cherubini, A, Baeyens, JP, Correa-Perez, A, Gudmundsson, A, Marengoni, A, O'Mahony, D, Parekh, N, Pisa, FE, Rajkumar, C, Wehling, M, and Ziere, Bert
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- 2019
23. Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus
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Rodriguez-Manas, L, Laosa, O, Vellas, B, Paolisso, G, Topinkova, E, Oliva-Moreno, J, Bourdel-Marchasson, I, Izquierdo, M, Hood, K, Zeyfang, A, Gambassi, Giovanni, Petrovic, Milica, Hardman, Tc, Kelson, Mj, Bautmans, I, Abellan, G, Barbieri, M, Pena-Longobardo, Lm, Regueme, Sc, Calvani, Riccardo, De Buyser, S, Sinclair, Aj, Gambassi, G (ORCID:0000-0002-7030-9359), Petrovic, M, Calvani, R (ORCID:0000-0001-5472-2365), Rodriguez-Manas, L, Laosa, O, Vellas, B, Paolisso, G, Topinkova, E, Oliva-Moreno, J, Bourdel-Marchasson, I, Izquierdo, M, Hood, K, Zeyfang, A, Gambassi, Giovanni, Petrovic, Milica, Hardman, Tc, Kelson, Mj, Bautmans, I, Abellan, G, Barbieri, M, Pena-Longobardo, Lm, Regueme, Sc, Calvani, Riccardo, De Buyser, S, Sinclair, Aj, Gambassi, G (ORCID:0000-0002-7030-9359), Petrovic, M, and Calvani, R (ORCID:0000-0001-5472-2365)
- Abstract
Background Type 2 diabetes, a highly prevalent chronic disease, is associated with increasing frailty and functional decline in older people. We aimed to evaluate the effectiveness of a multimodal intervention on functional performance in frail and pre-frail participants aged >= 70 years with type 2 diabetes mellitus. Methods The MID-Frail study was a cluster-randomized multicenter clinical trial conducted in 74 trial sites across seven European countries. The trial recruited 964 participants who were aged >70 years [mean age in intervention group, 78.4 (SD 5.6) years, 49.2% male and 77.6 (SD 5.29) years, 52.4% male in usual care group], with type diabetes mellitus and determined to be frail or pre-frail using Fried's frailty phenotype. Participants were allocated by trial site to follow either usual care (UCG) or intervention procedures (IG). Intervention group participants received a multimodal intervention composed of (i) an individualized and progressive resistance exercise programme for 16 weeks; (ii) a structured diabetes and nutritional educational programme over seven sessions; and (iii) Investigator-linked training to ensure optimal diabetes care. Short Physical Performance Battery (SPPB) scores were used to assess change in functional performance at 12 months between the groups. An analysis of the cost-effectiveness of the intervention was undertaken using the incremental cost-effectiveness ratio (ICER). Secondary outcomes included mortality, hospitalization, institutionalization, quality of life, burden on caregivers, the frequency and severity of hypoglycaemia episodes, and the cost-effectiveness of the intervention. Results After 12 months, IG participants had mean SPPB scores 0.85 points higher than those in the UCG (95% CI, 0.44 to 1.26, P < 0.0001). Dropouts were higher in frail participants and in the intervention group, but significant differences in SPPB between treatment groups remained consistent after sensitivity analysis. Estimates su
- Published
- 2019
24. Sante mentale des enfants et des adolescents - Depistage (SMEA-D) interRAI, manuel de l'utilisateur et formulaire d'evaluation, Edition canadienne-francaise
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Stewart, S.L., Hirdes, J.P., McKnight, M., Curtin-Telegdi, N., Perlman, C.M., MacLeod, K., Ninan, A., Currie, M., Carson, S., Morris, J.N., Berg, K., Bjorkgren, M., Declercq, A., Finne-Soveri, H., Fries, B.E., Gray, L., Head, M.J., James, M.L., Ljunggren, G., Meehan, B., Steel, K., Szczerbińska, Katarzyna, and Topinkova, E.
- Published
- 2018
25. The 'Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies' (SPRINTT) randomized controlled trial:case finding, screening and characteristics of eligible participants
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Marzetti, E. (Emanuele), Cesari, M. (Matteo), Calvani, R. (Riccardo), Msihid, J. (Jérôme), Tosato, M. (Matteo), Rodriguez-Mañas, L. (Leocadio), Lattanzio, F. (Fabrizia), Cherubini, A. (Antonio), Bejuit, R. (Raphaël), Di Bari, M. (Mauro), Maggio, M. (Marcello), Vellas, B. (Bruno), Dantoine, T. (Thierry), Cruz-Jentoft, A. J. (Alfonso J.), Sieber, C. C. (Cornel C.), Freiberger, E. (Ellen), Skalska, A. (Anna), Grodzicki, T. (Tomasz), Sinclair, A. J. (Alan J.), Topinkova, E. (Eva), Rýznarová, I. (Ingrid), Strandberg, T. (Timo), Schols, A. M. (Annemie M.W.J.), Schols, J. M. (Jos M.G.A.), Roller-Wirnsberger, R. (Regina), Jónsson, P. V. (Pálmi V.), Ramel, A. (Alfons), Del Signore, S. (Susanna), Pahor, M. (Marco), Roubenoff, R. (Ronenn), Bernabei, R. (Roberto), and Landi, F. (Francesco)
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Mobility disability ,Functional impairment ,Prevention ,Skeletal muscle ,Recruitment ,Physical performance - Abstract
Background: The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. Methods: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick “participant profiling” questionnaire was devised to facilitate PF&S case finding. Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. Conclusion: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.
- Published
- 2018
26. The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants
- Author
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Marzetti, Emanuele, Cesari, M., Calvani, Riccardo, Msihid, J., Tosato, Matteo, Rodriguez-Manas, L., Lattanzio, F., Cherubini, A., Bejuit, R., Di Bari, M., Maggio, M., Vellas, B., Dantoine, T., Cruz-Jentoft, A. J., Sieber, C. C., Freiberger, E., Skalska, A., Grodzicki, T., Sinclair, A. J., Topinkova, E., Ryznarova, I., Strandberg, T., Schols, A. M. W. J., Schols, J. M. G. A., Roller-Wirnsberger, R., Jonsson, P. V., Ramel, A., Del Signore, S., Pahor, M., Roubenoff, R., Bernabei, Roberto, Landi, Francesco, Marzetti E. (ORCID:0000-0001-9567-6983), Calvani R. (ORCID:0000-0001-5472-2365), Tosato M., Bernabei R. (ORCID:0000-0002-9197-004X), Landi F. (ORCID:0000-0002-3472-1389), Marzetti, Emanuele, Cesari, M., Calvani, Riccardo, Msihid, J., Tosato, Matteo, Rodriguez-Manas, L., Lattanzio, F., Cherubini, A., Bejuit, R., Di Bari, M., Maggio, M., Vellas, B., Dantoine, T., Cruz-Jentoft, A. J., Sieber, C. C., Freiberger, E., Skalska, A., Grodzicki, T., Sinclair, A. J., Topinkova, E., Ryznarova, I., Strandberg, T., Schols, A. M. W. J., Schols, J. M. G. A., Roller-Wirnsberger, R., Jonsson, P. V., Ramel, A., Del Signore, S., Pahor, M., Roubenoff, R., Bernabei, Roberto, Landi, Francesco, Marzetti E. (ORCID:0000-0001-9567-6983), Calvani R. (ORCID:0000-0001-5472-2365), Tosato M., Bernabei R. (ORCID:0000-0002-9197-004X), and Landi F. (ORCID:0000-0002-3472-1389)
- Abstract
Background: The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. Methods: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick “participant profiling” questionnaire was devised to facilitate PF&S case finding. Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. Conclusion: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefo
- Published
- 2018
27. PRM198 - STANDARD ERROR OF MEASUREMENT AND SMALLEST DETECTABLE CHANGE OF THE SARQOL® QUESTIONNAIRE: AN ANALYSIS OF SUBJECTS FROM 8 VALIDATION STUDIES
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Geerinck, A, primary, Beaudart, C, additional, Bautmans, I, additional, Cooper, C, additional, De Souza Orlandi, F, additional, Konstantynowicz, J, additional, Montero Errasquin, B, additional, Topinkova, E, additional, Tsekoura, M, additional, Reginster, J, additional, and Bruyère, O, additional
- Published
- 2018
- Full Text
- View/download PDF
28. The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods
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Landi, Francesco, Cesari, M., Calvani, Riccardo, Cherubini, A., Di Bari, M., Bejuit, R., Mshid, J., Andrieu, S., Sinclair, A. J., Sieber, C. C., Vellas, B., Topinkova, E., Strandberg, T., Rodriguez-Manas, L., Lattanzio, F., Pahor, M., Roubenoff, R., Cruz-Jentoft, A. J., Bernabei, Roberto, Marzetti, Emanuele, Landi F. (ORCID:0000-0002-3472-1389), Calvani R. (ORCID:0000-0001-5472-2365), Bernabei R. (ORCID:0000-0002-9197-004X), Marzetti E. (ORCID:0000-0001-9567-6983), Landi, Francesco, Cesari, M., Calvani, Riccardo, Cherubini, A., Di Bari, M., Bejuit, R., Mshid, J., Andrieu, S., Sinclair, A. J., Sieber, C. C., Vellas, B., Topinkova, E., Strandberg, T., Rodriguez-Manas, L., Lattanzio, F., Pahor, M., Roubenoff, R., Cruz-Jentoft, A. J., Bernabei, Roberto, Marzetti, Emanuele, Landi F. (ORCID:0000-0002-3472-1389), Calvani R. (ORCID:0000-0001-5472-2365), Bernabei R. (ORCID:0000-0002-9197-004X), and Marzetti E. (ORCID:0000-0001-9567-6983)
- Abstract
The sustainability of health and social care systems is threatened by a growing population of older persons with heterogeneous needs related to multimorbidity, frailty, and increased risk of functional impairment. Since disability is difficult to reverse in old age and is extremely burdensome for individuals and society, novel strategies should be devised to preserve adequate levels of function and independence in late life. The development of mobility disability, an early event in the disablement process, precedes and predicts more severe forms of inability. Its prevention is, therefore, critical to impede the transition to overt disability. For this reason, the Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT) project is conducting a randomized controlled trial (RCT) to test a multicomponent intervention (MCI) specifically designed to prevent mobility disability in high-risk older persons. SPRINTT is a phase III, multicenter RCT aimed at comparing the efficacy of a MCI, based on long-term structured physical activity, nutritional counseling/dietary intervention, and an information and communication technology intervention, versus a healthy aging lifestyle education program designed to prevent mobility disability in 1500 older persons with physical frailty and sarcopenia who will be followed for up to 36 months. The primary outcome of the SPRINTT trial is mobility disability, operationalized as the inability to walk for 400 m within 15 min, without sitting, help of another person, or the use of a walker. Secondary outcomes include changes in muscle mass and strength, persistent mobility disability, falls and injurious falls, disability in activities of daily living, nutritional status, cognition, mood, the use of healthcare resources, cost-effectiveness analysis, quality of life, and mortality rate. SPRINTT results are expected to promote significant advancements in the management of frail older persons a
- Published
- 2017
29. Healthy brain ageing and cognition: Nutritional factors
- Author
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Vandewoude, M, Barberger-Gateau, P, Cederholm, T, Mecocci, P, Salva, A, Sergi, G, Topinkova, E, and Van Asselt, D
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Ageing ,Macronutrient ,Micronutrient ,Dementia ,Medical food ,Diet - Abstract
Nutritional factors can influence the risk of Alzheimer's disease and its rate of clinical progression, suggesting that the association between diet, nutrient status and cognitive function deserves more attention. The European Union Geriatric Medicine Society (EUGMS) working group "Healthy Brain Ageing and Cognition" supports the development of practical recommendations for nutritional strategy, focused predominantly on the preventive aspects of diet and nutrition on cognitive decline. Adopting a healthy lifestyle and avoiding nutritional deficiencies in young or midlife adults is essential and there is compelling evidence to justify recommending a Mediterranean diet as a way of achieving these goals. There is currently insufficient evidence to endorse the use of specific nutrients to promote healthy brain ageing. In addition, currently there is no generally applicable evidence to recommend the use of single-agent micronutrient supplementation at any stage of dementia or for prevention. Omega-3 fatty acids or specific medical foods may be considered for selected patients with early dementia. When signs of malnutrition are detected, correction of specific deficiencies is necessary to improve nutritional status. Individuals at risk of malnutrition should be advised to improve nutritional intake from dietary food sources and should avoid taking high doses of specific nutrients as supplements. Nutritional awareness, advice and intervention are important in the general management and follow-up of people with cognitive problems. (C) 2015 Published by Elsevier Masson SAS.
- Published
- 2016
30. Healthy brain ageing and cognition : Nutritional factors
- Author
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Vandewoude, M., Barberger-Gateau, P., Cederholm, Tommy, Mecocci, P., Salva, A., Sergi, G., Topinkova, E., Van Asselt, D., Vandewoude, M., Barberger-Gateau, P., Cederholm, Tommy, Mecocci, P., Salva, A., Sergi, G., Topinkova, E., and Van Asselt, D.
- Abstract
Nutritional factors can influence the risk of Alzheimer's disease and its rate of clinical progression, suggesting that the association between diet, nutrient status and cognitive function deserves more attention. The European Union Geriatric Medicine Society (EUGMS) working group "Healthy Brain Ageing and Cognition" supports the development of practical recommendations for nutritional strategy, focused predominantly on the preventive aspects of diet and nutrition on cognitive decline. Adopting a healthy lifestyle and avoiding nutritional deficiencies in young or midlife adults is essential and there is compelling evidence to justify recommending a Mediterranean diet as a way of achieving these goals. There is currently insufficient evidence to endorse the use of specific nutrients to promote healthy brain ageing. In addition, currently there is no generally applicable evidence to recommend the use of single-agent micronutrient supplementation at any stage of dementia or for prevention. Omega-3 fatty acids or specific medical foods may be considered for selected patients with early dementia. When signs of malnutrition are detected, correction of specific deficiencies is necessary to improve nutritional status. Individuals at risk of malnutrition should be advised to improve nutritional intake from dietary food sources and should avoid taking high doses of specific nutrients as supplements. Nutritional awareness, advice and intervention are important in the general management and follow-up of people with cognitive problems.
- Published
- 2016
- Full Text
- View/download PDF
31. Dual Sensory Impairment and Cognitive Decline: The Results From the Shelter Study
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Yamada, Y, Denkinger, Md, Onder, Graziano, Henrard, J, Van Der Roest, Hg, Finne Soveri, H, Richter, T, Vlachova, M, Bernabei, Roberto, Topinkova, E., Onder, Graziano (ORCID:0000-0003-3400-4491), Bernabei, R (ORCID:0000-0002-9197-004X), Yamada, Y, Denkinger, Md, Onder, Graziano, Henrard, J, Van Der Roest, Hg, Finne Soveri, H, Richter, T, Vlachova, M, Bernabei, Roberto, Topinkova, E., Onder, Graziano (ORCID:0000-0003-3400-4491), and Bernabei, R (ORCID:0000-0002-9197-004X)
- Abstract
To examine whether nursing home residents with concurrent vision and hearing impairment, dual sensory impairment (DSI), have a greater cognitive decline over time than do those without sensory impairment and whether social engagement modifies this association.
- Published
- 2016
32. Statin treatment and mortality in community-dwelling frail older patients with diabetes mellitus
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Pilotto, A. (Alberto), Panza, F. (Francesco), Copetti, M. (Massimiliano), Simonato, M. (Matteo), Sancarlo, D. (Daniele), Gallina, P. (Pietro), Strandberg, T.E. (Timo), Cruz-Jentoft, A.J. (A.), Daragjati, J. (Julia), Ferrucci, L. (Luigi), Fontana, A. (Andrea), Maggi, S., Mattace Raso, F.U.S. (Francesco), Paccalin, M., Polidori, M.C. (Maria Cristina), Schulz, R.-J. (Ralf-Joachim), Topinkova, E., Trifirò, G. (Gianluca), Welmer, A.-K., Pilotto, A. (Alberto), Panza, F. (Francesco), Copetti, M. (Massimiliano), Simonato, M. (Matteo), Sancarlo, D. (Daniele), Gallina, P. (Pietro), Strandberg, T.E. (Timo), Cruz-Jentoft, A.J. (A.), Daragjati, J. (Julia), Ferrucci, L. (Luigi), Fontana, A. (Andrea), Maggi, S., Mattace Raso, F.U.S. (Francesco), Paccalin, M., Polidori, M.C. (Maria Cristina), Schulz, R.-J. (Ralf-Joachim), Topinkova, E., Trifirò, G. (Gianluca), and Welmer, A.-K.
- Abstract
Background: Older adults are often excluded from clinical trials. Decision making for administration of statins to older patients with diabetes mellitus (DM) is under debate, particularly in frail older patients with comorbidity and high mortality risk. We tested the hypothesis that statin treatment in older patients with DM was differentially effective across strata of mortality risk assessed by the Multidimensional Prognostic Index (MPI), based on information collected with the Standardized Multidimensional Assessment Schedule for Adults and Aged Persons (SVaMA). Methods: In this retrospective observational study, we estimated the mortality risk in 1712 community-dwelling subjects with DM ≥ 65 years who underwent a SVaMA evaluation to establish accessibility to homecare services/nursing home admission from 2005 to 2013 in the Padova Health District, Italy. Mild (MPI-SVaMA-1), moderate (MPI-SVaMA-2), and high (MPI-SVaMA-3) risk of mortality at baseline and propensity score-adjusted hazard ratios (HR) of three-year mortality were calculated according to statin treatment. Results: Higher MPI-SVaMA scores were associated with lower rates of statin treatment (MPI-SVaMA-1 = 39% vs MPI-SVaMA-2 = 36% vs MPI-SVaMA-3 = 24.9%. p<0.001) and higher three-year mortality (MPI-SVaMA-1 = 12.9% vs MPI-SVaMA-2 = 24% vs MPI-SVaMA-3 = 34.4%, p<0.001). After adjustment for propensity score quintiles, statin treatment was significantly associated with lower three-year mortality irrespective of MPI-SVaMA group (interaction test p = 0.303). HRs [95% confidence interval (CI)] were 0.19 (0.14-0.27), 0.28 (0.21-0.36), and 0.26 (0.20-0.34) in the MPI-SVaMA-1, MPI-SVaMA-2, and MPI-SVaMA-3 groups, respectively. Subgroup analyses showed that statin treatment was also beneficial irrespective of age. HRs (95% CI) were 0.21 (0.15-0.31), 0.26 (0.20-0.33), and 0.26 (0.20-0.35) among patients aged 65-74, 75-84, and ≥ 85 years, respectively (interaction test p=0.812). Conclusions: Statin treatment was
- Published
- 2015
- Full Text
- View/download PDF
33. Inappropriate drug use in advanced dementia
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Colloca, G, Bernabei, R, Topinkova, E, ONDER, GRAZIANO, Colloca, G, Bernabei, R, Topinkova, E, and ONDER, GRAZIANO
- Published
- 2015
34. The MPI_AGE European Project: Using Multidimensional Prognostic Indices (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons. Background, aim and design
- Author
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Pilotto, A., Sancarlo, D., Polidori, M. C., Cruz-Jentoft, A. J., Mattace-Raso, F., Paccalin, M., Topinkova, E., Welmer, A. -K., Maggi, S., Pilotto, A., Sancarlo, D., Polidori, M. C., Cruz-Jentoft, A. J., Mattace-Raso, F., Paccalin, M., Topinkova, E., Welmer, A. -K., and Maggi, S.
- Abstract
Purpose: The MPI_AGE project is a multicenter project co-funded by the Executive Agency for Health and Consumers in the frame of Active and Healthy Ageing 2nd-Health Programme 2008-2013. Aim of the project is to implement Multidimensional Prognostic Indices (MPI) that predict survival, based on the Comprehensive Geriatric Assessment, in order to improve the cost-effectiveness of health interventions in frail older individuals with multimorbidity and polypharmacy. Materials and methods: The project is divided in seven Work Packages (WP). WP1, WP2 and WP3 include the activities of coordination, evaluation and dissemination, respectively. WP4 is a retrospective analysis of clinical, functional and administrative data carried out in order to develop and validate MPI in community-dwelling older subjects. In WP5, the best cost-effective profile of different therapeutic interventions in older individuals with different MPI-based mortality risk profile will be identified. WP6 is a multicenter prospective study with a follow-up of 12 months carried out in 11 geriatric clinical centres with the aim of evaluating the usefulness of the MPI in the clinical decision making in patients with different mortality risk. In WP7, a systematic process of recommendations will be carried out through the wide involvement of partners, external experts and stakeholders in meetings and web diffusion. Conclusions: Mortality risk may influence the effectiveness of specific treatments and interventions in frail older subjects with multimorbidity and polypharmacy. Clinicians and health policy makers need to consider the prognostic information obtained through the MPI to identify those setting-specific profiles of older subjects who may better benefit from interventions. (C) 2015 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.
- Published
- 2015
35. O-048: Vaccination and survival in a population of older adult living in nursing home
- Author
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Collamati, Agnese, Landi, Francesco, Poscia, Andrea, Topinkova, E, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Poscia, Andrea (ORCID:0000-0002-7616-3389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Onder, Graziano (ORCID:0000-0003-3400-4491), Collamati, Agnese, Landi, Francesco, Poscia, Andrea, Topinkova, E, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Poscia, Andrea (ORCID:0000-0002-7616-3389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Onder, Graziano (ORCID:0000-0003-3400-4491)
- Abstract
Influenza and pneumococcal vaccines have been proved to be effective and safe in preventing and controlling infection among elderly, reducing morbidity and mortality. However, some evidences raised health concerns related to these vaccinations. OBJECTIVES: Aim of the present study is to identify prevalence and outcomes related to influenza and pneumococcal vaccinations in a large European population of frail old people living in nursing home(NH).
- Published
- 2015
36. Quality of care in European home care programs using the second generation interRAI Home Care Quality Indicators (HCQIs)
- Author
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Foebel, Ad, Van Hout, Hp, Van Der Roest, Hg, Topinkova, E, Garms Homolova, V, Frijters, D, Finne Soveri, H, Jónsson, Pv, Hirdes, Jp, Bernabei, Roberto, Onder, Graziano, Bernabei, R (ORCID:0000-0002-9197-004X), Onder, Graziano (ORCID:0000-0003-3400-4491), Foebel, Ad, Van Hout, Hp, Van Der Roest, Hg, Topinkova, E, Garms Homolova, V, Frijters, D, Finne Soveri, H, Jónsson, Pv, Hirdes, Jp, Bernabei, Roberto, Onder, Graziano, Bernabei, R (ORCID:0000-0002-9197-004X), and Onder, Graziano (ORCID:0000-0003-3400-4491)
- Abstract
Evaluating the quality of care provided to older individuals is a key step to ensure that needs are being met and to target interventions to improve care. To this aim, interRAI's second-generation home care quality indicators (HCQIs) were developed in 2013. This study assesses the quality of home care services in six European countries using these HCQIs as well as the two derived summary scales.
- Published
- 2015
37. Joint Associations of Dual Sensory Impairment and No-Activity Involvement With 1-Year Mortality in Nursing Homes: Results From the SHELTER Study
- Author
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Yamada, Y, Denkinger, Md, Onder, Graziano, Van Der Roest, Hg, Finne Soveri, H, Bernabei, Roberto, Topinkova, E., Onder, Graziano (ORCID:0000-0003-3400-4491), Bernabei, R (ORCID:0000-0002-9197-004X), Yamada, Y, Denkinger, Md, Onder, Graziano, Van Der Roest, Hg, Finne Soveri, H, Bernabei, Roberto, Topinkova, E., Onder, Graziano (ORCID:0000-0003-3400-4491), and Bernabei, R (ORCID:0000-0002-9197-004X)
- Abstract
Concurrent vision and hearing impairment, known as dual sensory impairment (DSI), is associated with increased mortality. We aimed to examine individual and joint associations of DSI and involvement in activities with mortality in a large European nursing home study.
- Published
- 2015
38. Impact of dual sensory impairment on onset of behavioral symptoms in European nursing homes: results from the Services and Health for Elderly in Long-Term Care study
- Author
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Yamada, Y, Denkinger, Md, Onder, Graziano, Finne Soveri, H, Van Der Roest, H, Vlachova, M, Richter, T, Gindin, J, Bernabei, R, Topinkova, E., Onder, Graziano (ORCID:0000-0003-3400-4491), Bernabei, R (ORCID:0000-0002-9197-004X), Yamada, Y, Denkinger, Md, Onder, Graziano, Finne Soveri, H, Van Der Roest, H, Vlachova, M, Richter, T, Gindin, J, Bernabei, R, Topinkova, E., Onder, Graziano (ORCID:0000-0003-3400-4491), and Bernabei, R (ORCID:0000-0002-9197-004X)
- Abstract
To investigate if dual sensory impairment (DSI) in the form of a combined visual and hearing impairment is associated with the onset of behavioral symptoms in nursing homes.
- Published
- 2015
39. Treating heart failure in older and oldest old patients
- Author
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Vetrano, Dl, Lattanzio, F, Martone, Am, Landi, F, Brandi, V, Topinkova, E, Onder, Graziano, Onder, Graziano (ORCID:0000-0003-3400-4491), Vetrano, Dl, Lattanzio, F, Martone, Am, Landi, F, Brandi, V, Topinkova, E, Onder, Graziano, and Onder, Graziano (ORCID:0000-0003-3400-4491)
- Abstract
Advanced age is a relevant risk factor for the heart failure (HF). The development of new pharmacological and non-pharmacological approaches has determined an improvement in survival of patients with HF, leading to the selection of an older and frailer population with HF. The clinical approach to such a complex population should require clear indications to assist physicians during their daily practice, but there is a huge lack of evidence regarding the treatment of HF in the oldest among the elderly patient population. In addition, the co-occurrence of specific conditions that are extremely prevalent in older individuals with HF, such as cognitive impairment, comorbidities, and polypharmacy, can further complicate the clinical man agement of this condition. Thus, a multidisciplinary approach with the goal of recognizing and treating conditions associated with HF may be necessary to improve the quality of care and to reduce expenditures. Several studies have assessed the effect of a comprehensive geriatric assessment and management on quality of care in HF patients, demonstrating a substantial improvement in patient outcomes and administration of the appropriate drug treatment.
- Published
- 2015
40. Nutrition in the age-related disablement process
- Author
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Inzitari, M., Doets, E., Bertali, B., Benetou, V., DI BARI, M., Visser, M., Volpato, S., Gambassi, G., Topinkova, E., DE GROT, L., Salva, A., INTERNATIONAL ASSOCIATION OF GERENTOLOGY AND GERIATRICS TASK FORCE NUTRITION IN THE ELDERLY, and Zamboni, Mauro
- Subjects
nutrition ,nutrition and aging - Published
- 2011
41. NUTRITION IN THE AGE-RELATED DISABLEMENT PROCESS
- Author
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Inzitari, M. Doets, E. Bartali, B. Benetou, V. Di Bari, M. Visser, M. Volpato, S. Gambassi, G. Topinkova, E. and De Groot, L. Salva, A. Int Assoc Gerontology & Geriatrics
- Abstract
The transition from independence to disability in older adults is characterized by detectable changes in body composition and physical function. Epidemiologic studies have shown that weight loss, reduced caloric intake and the reduced intake of specific nutrients are associated with such changes. The mechanisms underlying these associations remain unclear, and different hypotheses have been suggested, including the reduction of the antioxidant effects of some nutrients. Changes in muscle mass and quality might play a central role in the pathway linking malnutrition, its biological and molecular consequences, and function. A different approach aims at assessing diets by dietary patterns, which capture intercorrelations of nutrients within a diet, rather than by selective foods or nutrients: epidemiologic evidence suggests that some types of diet, such as the Mediterranean diet, might prevent negative functional outcomes in older adults. However, despite a theoretical and empirical basis, intervention studies using nutritional supplementation have shown inconclusive results in preventing functional impairment and disability. The present work is the result of a review and consensus effort of a European task force on nutrition in the elderly, promoted by the International association of Gerontology and Geriatrics (IAGG) European region. After the critical review of different aspects related to the role of nutrition in the transition from independence to disability, we propose future lines for research, including the determination of levels of inadequacy and target doses of supplements, the study of interactions (between nutrients within a diet and with other lifestyle aspects), and the association with functional outcomes.
- Published
- 2011
42. Two is better than one: vaccination impact on survival of older adult living in nursing home
- Author
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Poscia, A, primary, Collamati, A, additional, Collamati, V, additional, Moscato, U, additional, Topinkova, E, additional, Landi, F, additional, Bernabei, R, additional, and Onder, G, additional
- Published
- 2015
- Full Text
- View/download PDF
43. Using Multidimensional Prognostic Indices (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons: Aims and design of the EU-funded MPI_AGE project
- Author
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Nelles, M. C. Polidori, Cruz-Jentoft, A., Maggi, S., Paccalin, M., Sancarlo, D., Topinkova, E., Trifiro, G., Welmer, A. K., Pilotto, A., Nelles, M. C. Polidori, Cruz-Jentoft, A., Maggi, S., Paccalin, M., Sancarlo, D., Topinkova, E., Trifiro, G., Welmer, A. K., and Pilotto, A.
- Published
- 2014
44. Unintended weight loss in the elderly living at home: the aged in homecare project (Adhoc)
- Author
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Sørbye, Liv Wergeland, Schroll, M., Finne-Soveri, H., Jonsson, P.V., Ljunggren, G., Topinkova, E., and Bernabei, R.
- Subjects
vitenskapelig (fagfellevurdert) ,vekttap ,eldre ,malnutrition ,weight loss ,home care ,elderly ,hjemmetjenester ,ernæring - Abstract
Objective: To describe associations between unintended weight loss (UWL) and characteristics of nutritional status. Design: A comparative cross-sectional assessment study at 11 sites in Europe. The target population was a stratified random sample of 4,455 recipients of home care (405 in each random sample from 11 urban areas) aged 65 years and older. Measurements: the Resident Assessment Instrument for Home Care, version 2.0. Epidemiological and medical characteristics of clients and service utilisation were recorded in a standardized, comparative manner. UWL was defined as information of 5% or more weight loss in the last 30 days (or 10% or more in the last 180 days). Results: The final sample consisted of 4,010 persons; 74% were female. The mean ages were 80.9 ± 7.5 years (males) and 82.8 ± 7.3 years (females). No associations were found between single diagnoses and UWL, except for cancer. Cancer patients were excluded from further analyses. Persons with a Cognitive Performance Scale value (CPS) > 3 (impaired) had increased risk of UWL (OR = 2.0) compared with those scoring < 3 (less impaired). Only in the oldest group did we find a significant association between UWL and reduction in ADL and IADL functions, comparing those who scored 3 or less with those who scored more than 3 (disabled). A binary logistic regression model explained 26% of UWL: less than one meal/day, reduced appetite, malnutrition, reduced social activity, experiencing a flare-up of a recurrent or chronic problem, and hospitalisation were important indicators. Conclusion: We recommend a regular comprehensive assessment in home care to identify clients with potential risk factors for weight loss and malnutrition, in particular those discharged from hospital, and those with physical dependency or cognitive problems. This study may provide incentives to create tailored preventive strategies.
- Published
- 2008
45. THE EUROPEAN UNION GERIATRIC MEDICINE SOCIETY (EUGMS) WORKING GROUP ON \'FRAILTY IN OLDER PERSONS\'
- Author
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Cesari, M, Abellan Van Kan, G, Ariogul, S, Baeyens, J.P., Bauer, J, Cankurtaran, M, Cederholm, Tommy, Cherubini, A, Cruz-Jentoft, A.J., Curgunlu, A, Landi, F, Sayer, A.A, Strandberg, T, Topinkova, E, Van Asselt, D, Vellas, B, Zekry, D, Michel, JP, Cesari, M, Abellan Van Kan, G, Ariogul, S, Baeyens, J.P., Bauer, J, Cankurtaran, M, Cederholm, Tommy, Cherubini, A, Cruz-Jentoft, A.J., Curgunlu, A, Landi, F, Sayer, A.A, Strandberg, T, Topinkova, E, Van Asselt, D, Vellas, B, Zekry, D, and Michel, JP
- Published
- 2013
46. Polypharmacy in nursing home residents with severe cognitive impairment: results from the SHELTER Study
- Author
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Vetrano, Dl, Tosato, Matteo, Colloca, Giuseppe Ferdinando, Topinkova, E, Fialova, D, Gindin, J, Van Der Roest, Hg, Landi, Francesco, Liperoti, Rosa, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Onder, Graziano (ORCID:0000-0003-3400-4491), Vetrano, Dl, Tosato, Matteo, Colloca, Giuseppe Ferdinando, Topinkova, E, Fialova, D, Gindin, J, Van Der Roest, Hg, Landi, Francesco, Liperoti, Rosa, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Onder, Graziano (ORCID:0000-0003-3400-4491)
- Abstract
Pharmacological treatment of older adults with cognitive impairment represents a challenge for prescribing physicians, and polypharmacy is common in these complex patients. The aim of the current study is to assess prevalence and factors related to polypharmacy in a sample of nursing home (nursing home) residents with advanced cognitive impairment.
- Published
- 2013
47. Pain characteristics and pain control in European nursing homes: cross-sectional and longitudinal results from the Services and Health for Elderly in Long TERm care (SHELTER) study
- Author
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Lukas, A, Mayer, B, Fialová, D, Topinkova, E, Gindin, J, Onder, Graziano, Bernabei, Roberto, Nikolaus, T, Denkinger, Md, Onder, Graziano (ORCID:0000-0003-3400-4491), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Lukas, A, Mayer, B, Fialová, D, Topinkova, E, Gindin, J, Onder, Graziano, Bernabei, Roberto, Nikolaus, T, Denkinger, Md, Onder, Graziano (ORCID:0000-0003-3400-4491), and Bernabei, Roberto (ORCID:0000-0002-9197-004X)
- Abstract
Few studies have compared cross-national characteristics of residents with pain in European long term care facilities. The SHELTER project, a cross-national European study on nursing home residents, provides the opportunity to examine this issue. The present study aimed to evaluate key figures about pain and compare them with seven European countries and Israel.
- Published
- 2013
48. Polypharmacy and mortality among nursing home residents with advanced cognitive impairment: results from the SHELTER study
- Author
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Onder, Graziano, Liperoti, Rosa, Foebel, A, Fialova, D, Topinkova, E, Van Der Roest, Hg, Gindin, J, Cruz Jentoft, Aj, Fini, M, Gambassi, Giovanni, Bernabei, Roberto, Onder, Graziano (ORCID:0000-0003-3400-4491), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Gambassi, Giovanni (ORCID:0000-0002-7030-9359), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Onder, Graziano, Liperoti, Rosa, Foebel, A, Fialova, D, Topinkova, E, Van Der Roest, Hg, Gindin, J, Cruz Jentoft, Aj, Fini, M, Gambassi, Giovanni, Bernabei, Roberto, Onder, Graziano (ORCID:0000-0003-3400-4491), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Gambassi, Giovanni (ORCID:0000-0002-7030-9359), and Bernabei, Roberto (ORCID:0000-0002-9197-004X)
- Abstract
Older adults with advanced cognitive impairment have a limited life expectancy and the use of multiple drugs is of questionable benefit in this population. The aim of the present study was to assess if, in a sample of nursing home (NH) residents with advanced cognitive impairment, the effect of polypharmacy on mortality differs depending on estimated life expectancy.
- Published
- 2013
49. Treatment of pain in European nursing homes: results from the Services and Health for Elderly in Long TERm Care (SHELTER) study
- Author
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Lukas, A, Mayer, B, Fialová, D, Topinkova, E, Gindin, J, Onder, Graziano, Bernabei, Roberto, Nikolaus, T, Denkinger, Md, Onder, Graziano (ORCID:0000-0003-3400-4491), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Lukas, A, Mayer, B, Fialová, D, Topinkova, E, Gindin, J, Onder, Graziano, Bernabei, Roberto, Nikolaus, T, Denkinger, Md, Onder, Graziano (ORCID:0000-0003-3400-4491), and Bernabei, Roberto (ORCID:0000-0002-9197-004X)
- Abstract
To identify pharmacological and nonpharmacological pain management approaches and associated factors in nursing home residents across Europe.
- Published
- 2013
50. Inappropriate drugs in elderly patients with severe cognitive impairment: results from the shelter study
- Author
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Colloca, Giuseppe Ferdinando, Tosato, Matteo, Vetrano, Davide Liborio, Topinkova, E, Fialova, D, Gindin, J, Van Der Roest, Hg, Landi, Francesco, Liperoti, Rosa, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Onder, Graziano (ORCID:0000-0003-3400-4491), Colloca, Giuseppe Ferdinando, Tosato, Matteo, Vetrano, Davide Liborio, Topinkova, E, Fialova, D, Gindin, J, Van Der Roest, Hg, Landi, Francesco, Liperoti, Rosa, Bernabei, Roberto, Onder, Graziano, Landi, Francesco (ORCID:0000-0002-3472-1389), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Onder, Graziano (ORCID:0000-0003-3400-4491)
- Abstract
It has been estimated that Nursing Home (NH) residents with impaired cognitive status receive an average of seven to eight drugs daily. The aim of this study was to determine prevalence and factors associated with use of inappropriate drugs in elderly patients with severe cognitive impairment living in NH in Europe.
- Published
- 2012
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