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10 results on '"Tongfei Cheng"'

1. Associations between gut microbiota and adverse neurodevelopmental outcomes in preterm infants: a two-sample Mendelian randomization study

Author

Yuqian Wang, Tongfei Cheng, Yifan Cui, Danyang Qu, Xin Peng, Liu Yang, and Xuwu Xiao

Subjects
Mendelian randomization, instrumental variable, gut microbiota, neurodevelopmental outcome, preterm infant, causal relationship, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Gut microbiota are associated with adverse neurodevelopmental outcomes in preterm infants; however, the precise causal relationship remains unclear. In this study, we conducted a two-sample Mendelian randomization (MR) analysis to comprehensively study the relationship between gut microbiota and adverse neurodevelopmental outcomes in preterm infants and identify specific causal bacteria that may be associated with the occurrence and development of adverse neurodevelopmental outcomes in preterm infants. The genome-wide association analysis (GWAS) of the MiBioGen biogroup was used as the exposure data. The GWAS of six common adverse neurodevelopmental outcomes in premature infants from the FinnGen consortium R9 was used as the outcome data. Genetic variations, namely, single nucleotide polymorphisms (SNPs) below the locus-wide significance level (1 × 10−5) and genome-wide statistical significance threshold (5 × 10−8) were selected as instrumental variables (IVs). MR studies use inverse variance weighting (IVW) as the main method. To supplement this, we also applied three additional MR methods: MR-Egger, weighted median, and weighted mode. In addition, the Cochrane’s Q test, MR-Egger intercept test, Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), and leave-one-out methods were used for sensitivity analysis. Our study shows a causal relationship between specific gut microbiota and neurodevelopmental outcomes in preterm infants. These findings provide new insights into the mechanism by which gut microbiota may mediate adverse neurodevelopmental outcomes in preterm infants.

Published
2024
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2. Study of Icaritin Films by Low-Energy Electron Beam Deposition

Author

Tongfei Cheng, Jinxing Cao, Xiaohong Jiang, M.A. Yarmolenko, A.A. Rogachev, and A.V. Rogachev

Subjects
low-energy electron beam deposition, icaritin film, material characterization, film release, biocompatibility, Chemistry, QD1-999
Abstract

In this paper, icaritin film was prepared by low-energy beam electron beam deposition (EBD). The material test showed that the structure and composition of icaritin were not changed after electron beam deposition. Then, the film was sliced and immersed in simulated body fluids, it can be seen that the film was released quickly in the first 7 days. With the extension of soaking time, the release rate gradually slowed down, and the release amount exceeded 90% in about 20 days. In vitro cytotoxicity test showed that the relative cell viability rate of the film was still 92.32±1.30% (p

Published
2021
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7. The effectiveness and safety of scraping therapy in adjuvant treatment of fever caused by COVID-19：A Protocol for Systematic Review

Author

Hongzhou Chen, Dan Wang, Xianbing Hou, Dandan Chen, Yao Wang, Hui Xu, Xiaojun Dai, Yuanyuan Wang, Bixian Cui, and Tongfei Cheng

Subjects
Protocol (science), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Internal medicine, medicine.medical_treatment, medicine, business, Adjuvant
Published
2021
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8. Study of Icaritin Films by Low-Energy Electron Beam Deposition

Author

A.A. Rogachev, Jinxing Cao, Tongfei Cheng, M.A. Yarmolenko, Xiaohong Jiang, and A.V. Rogachev

Subjects
Materials science, Biocompatibility, General Chemical Engineering, In vitro cytotoxicity, material characterization, General Chemistry, low-energy electron beam deposition, Condensed Matter Physics, Beam electron, Chemistry, biocompatibility, Low energy, Electron beam deposition, film release, General Materials Science, icaritin film, QD1-999, Deposition (chemistry), Beam (structure), Nuclear chemistry
Abstract

In this paper, icaritin film was prepared by low-energy beam electron beam deposition (EBD). The material test showed that the structure and composition of icaritin were not changed after electron beam deposition. Then, the film was sliced and immersed in simulated body fluids, it can be seen that the film was released quickly in the first 7 days. With the extension of soaking time, the release rate gradually slowed down, and the release amount exceeded 90% in about 20 days. In vitro cytotoxicity test showed that the relative cell viability rate of the film was still 92.32±1.30% (p

Published
2021
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9. Acupuncture treatment for nausea and vomiting after chemotherapy

Author

Dan Wang, Hongzhou Chen, Yao Wang, Xianbing Hou, Xiaojun Dai, Yuanyuan Wang, Bixian Cui, Tongfei Cheng, Hui Xu, and Dandan Chen

Subjects
Protocol (science), Chemotherapy, Nausea, business.industry, medicine.medical_treatment, Anesthesia, medicine, Vomiting, medicine.symptom, Acupuncture treatment, business
Published
2021
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10. Effect of OLIG1 on the development of oligodendrocytes and myelination in a neonatal rat PVL model induced by hypoxia-ischemia

Author

Xindong Xue, Jianhua Fu, and Tongfei Cheng

Subjects
Male, Cancer Research, Pathology, medicine.medical_specialty, Necrosis, Leukomalacia, Periventricular, OLIG1, Gene Expression, Nerve Tissue Proteins, Biochemistry, neonatal, Andrology, Myelin, Western blot, Gene expression, Basic Helix-Loop-Helix Transcription Factors, Genetics, medicine, Animals, RNA, Messenger, Molecular Biology, Myelin Sheath, Periventricular leukomalacia, biology, medicine.diagnostic_test, Brain, Myelin Basic Protein, Articles, medicine.disease, Immunohistochemistry, Oligodendrocyte, Rats, Myelin basic protein, Oligodendroglia, myelin, hypoxia-ischemia, medicine.anatomical_structure, Animals, Newborn, Oncology, Apoptosis, Hypoxia-Ischemia, Brain, biology.protein, Molecular Medicine, Female, PVL, medicine.symptom, oligodendrocyte
Abstract

OLIG1 is an oligodendrocyte (OL) transcription factor, which can contribute to the proliferation and differentiation of OLs, and the maturation of myelin. The aim of this study was to clarify the role of OLIG1 in neonatal Sprague Dawley rats with periventricular leukomalacia (PVL), induced by hypoxia-ischemia (HI). Newborn rats in the HI group were subjected to ligation of the right carotid artery, followed by 8% oxygen delivery for 2 h, while rats in the normoxia group were only subjected to isolation of the right carotid artery, without exposure to hypoxia. Samples of brain tissue from rats in both groups were collected at 1, 3, 7, 14 and 21 days. In the HI group, observation by transmission electron microscopy (TEM) revealed OLs with a damaged nuclear membrane, cellular atrophy, deformation and necrosis, and cells in myelin with a high number of small vacuoles. A double-label immunofluorescence assay revealed the translocation of OLIG1 from the cytoplasm to the nucleus, while western blot and reverse transcription-quantitative polymerase chain reaction assays showed that there is a significant decrease, followed by an increase, in the gene and protein expression levels of OLIG1 and myelin basic protein (MBP). Despite the increase at the late stages of HI, the final levels of these proteins remained lower than the corresponding levels in the normoxia group. In conclusion, the decreased protein expression of OLIG1 following HI plays an important role in inhibiting the development and maturation of OLs and myelin. Although OLIG1 may, via its nuclear translocation, promote the growth and development of myelin to a certain extent, this factor fails to fully repair injured myelin.

Published
2014
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