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2. Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, and James, Cynthia A.

Published
2024
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3. Individualized Family Screening for Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Muller, Steven A., Gasperetti, Alessio, Bosman, Laurens P., Schmidt, Amand F., Baas, Annette F., Amin, Ahmad S., Houweling, Arjan C., Wilde, Arthur A.M., Compagnucci, Paolo, Targetti, Mattia, Casella, Michela, Calò, Leonardo, Tondo, Claudio, van der Harst, Pim, Asselbergs, Folkert W., van Tintelen, J. Peter, Oerlemans, Marish I.F.J., and te Riele, Anneline S.J.M.

Published
2023
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4. Matching Ablation Endpoints to Long-Term Outcome: The Prospective Multicenter Italian Ventricular Tachycardia Ablation Registry

Author

Radinovic, Andrea, Peretto, Giovanni, Sgarito, Giuseppe, Cauti, Filippo Maria, Castro, Antonello, Narducci, Maria Lucia, Mantovan, Roberto, Scaglione, Marco, Solimene, Francesco, Scopinaro, Alice, Tondo, Claudio, Filippini, Giulia, Bianco, Elisabetta, Bonso, Aldo, Calzolari, Vittorio, Ferraris, Federico, Zardini, Marco, Piacenti, Marcello, D’Angelo, Giuseppe, Bosica, Francesco, and Della Bella, Paolo

Published
2023
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8. Novel SCN5A gene mutation in a patient affected by multifocal ectopic premature Purkinje‐related contractions syndrome.

Author

Ventrella, Nicoletta, Bianchini, Lorenzo, Riva, Stefania, Pizzamiglio, Francesca, Dessanai, Maria Antonietta, Tundo, Fabrizio, Sattin, Tommaso, De Lio, Francesca, Cellucci, Selene, and Tondo, Claudio

Subjects
LEFT ventricular dysfunction, GENETIC disorders, SYMPTOMS, VENTRICULAR ejection fraction, HEART failure
Abstract

We report the case of a 36‐year‐old woman who presented to the emergency department complaining of palpitations and asthenia. Investigations showed frequent ventricular ectopy and severe left ventricular ejection fraction impairment. She was diagnosed with a peculiar condition defined multifocal ectopic premature Purkinje‐related contractions syndrome, which in some cases can be associated with a dilated cardiomyopathy phenotype. Genetic testing showed a novel mutation in the SCN5A gene (c.673C > G). In the context of acute left ventricular dysfunction in a young patient, we discuss the clinical presentation of this rare condition and its clinical management, as well as its genetic substrate. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Long-Term Outcomes of Near-Zero Radiation Ablation of Paroxysmal Supraventricular Tachycardia: A Comparison With Fluoroscopy-Guided Approach

Author

Bergonti, Marco, Dello Russo, Antonio, Sicuso, Rita, Ribatti, Valentina, Compagnucci, Paolo, Catto, Valentina, Gasperetti, Alessio, Zucchetti, Martina, Cellucci, Selene, Vettor, Giulia, Dessanai, Maria Antonietta, Majocchi, Benedetta, Moltrasio, Massimo, Russo, Eleonora, Stronati, Giulia, Guerra, Federico, Di Biase, Luigi, Natale, Andrea, Tondo, Claudio, and Casella, Michela

Published
2021
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11. Abstract 15458: Incidence of Ventricular Arrhythmias Related to Covid Infection and Vaccination in Patients With Brugada Syndrome: Insights From a Large Italian Multicenter Study

Author

Conti, Sergio, Dello Russo, Antonio, Compagnucci, Paolo, Massara, Francesca, Tondo, Claudio, Ribatti, Valentina, Marcon, Lorenzo, Pelargonio, Gemma, Narducci, Maria Lucia, De Francesco, Luca, Calo, Leonardo, Martino, Annamaria, Balla, Cristina, Iacopino, Saverio, Sgarito, Giuseppe, Patti, Giuseppe, Ghiglieno, Chiara, DellʼEra, Gabriele, Forleo, Giovanni B, Schiavone, Marco, and Casella, Michela

Published
2022
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12. Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe

Author

Arts Assistenten Cardiologie, Genetica Groep Van Tintelen, Cancer, Child Health, Circulatory Health, Team Onderzoek, Carrick, Richard T, De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P, Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A M, Davies, Brianna, Seifer, Colette, Roberts, Jason D, Healey, Jeff S, MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J, Targetti, Mattia, Calò, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K, Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E, Di Marco, Andrea, Jordà, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Delinière, Antoine, Biernacka, Elżbieta K, van Tintelen, J Peter, Platonov, Pyotr G, Olivotto, Iacopo, Saguner, Ardan M, Haugaa, Kristina H, Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D, Te Riele, Anneline S J M, Wu, Katherine C, Calkins, Hugh, James, Cynthia A, Cadrin-Tourigny, Julia, Arts Assistenten Cardiologie, Genetica Groep Van Tintelen, Cancer, Child Health, Circulatory Health, Team Onderzoek, Carrick, Richard T, De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P, Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A M, Davies, Brianna, Seifer, Colette, Roberts, Jason D, Healey, Jeff S, MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J, Targetti, Mattia, Calò, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K, Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E, Di Marco, Andrea, Jordà, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Delinière, Antoine, Biernacka, Elżbieta K, van Tintelen, J Peter, Platonov, Pyotr G, Olivotto, Iacopo, Saguner, Ardan M, Haugaa, Kristina H, Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D, Te Riele, Anneline S J M, Wu, Katherine C, Calkins, Hugh, James, Cynthia A, and Cadrin-Tourigny, Julia

Published
2024

13. Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe

Author

Carrick, Richard T., De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P., Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A. M., Davies, Brianna, Seifer, Colette, Roberts, Jason D., Healey, Jeff S., MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J., Targetti, Mattia, Calo, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K., Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E., Di Marco, Andrea, Jorda, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Deliniere, Antoine, Biernacka, Elzbieta K., van Tintelen, J. Peter, Platonov, Pyotr G., Olivotto, Iacopo, Saguner, Ardan M., Haugaa, Kristina H., Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D., te Riele, Anneline S. J. M., Wu, Katherine C., Calkins, Hugh, James, Cynthia A., Cadrin-Tourigny, Julia, Carrick, Richard T., De Marco, Corrado, Gasperetti, Alessio, Bosman, Laurens P., Gourraud, Jean-Baptiste, Trancuccio, Alessandro, Mazzanti, Andrea, Murray, Brittney, Pendleton, Catherine, Tichnell, Crystal, Tandri, Harikrishna, Zeppenfeld, Katja, Wilde, Arthur A. M., Davies, Brianna, Seifer, Colette, Roberts, Jason D., Healey, Jeff S., MacIntyre, Ciorsti, Alqarawi, Wael, Tadros, Rafik, Cutler, Michael J., Targetti, Mattia, Calo, Leonardo, Vitali, Francesco, Bertini, Matteo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Cappelletto, Chiara, De Luca, Antonio, Stolfo, Davide, Duru, Firat, Jensen, Henrik K., Svensson, Anneli, Dahlberg, Pia, Hasselberg, Nina E., Di Marco, Andrea, Jorda, Paloma, Arbelo, Elena, Moreno Weidmann, Zoraida, Borowiec, Karolina, Deliniere, Antoine, Biernacka, Elzbieta K., van Tintelen, J. Peter, Platonov, Pyotr G., Olivotto, Iacopo, Saguner, Ardan M., Haugaa, Kristina H., Cox, Moniek, Tondo, Claudio, Merlo, Marco, Krahn, Andrew D., te Riele, Anneline S. J. M., Wu, Katherine C., Calkins, Hugh, James, Cynthia A., and Cadrin-Tourigny, Julia

Abstract

Background and Aims Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences in utilization of primary prevention ICDs and survival free from sustained ventricular arrhythmia (VA) in ARVC.Methods This was a retrospective analysis of ARVC patients without prior VA enrolled in clinical registries from 11 countries throughout Europe and North America. Patients were classified according to whether they received treatment in North America or Europe and were further stratified by baseline predicted VA risk into low- (<10%/5 years), intermediate- (10%-25%/5 years), and high-risk (>25%/5 years) groups. Differences in ICD implantation and survival free from sustained VA events (including appropriate ICD therapy) were assessed.Results One thousand ninety-eight patients were followed for a median of 5.1 years; 554 (50.5%) received a primary prevention ICD, and 286 (26.0%) experienced a first VA event. After adjusting for baseline risk factors, North Americans were more than three times as likely to receive ICDs {hazard ratio (HR) 3.1 [95% confidence interval (CI) 2.5, 3.8]} but had only mildly increased risk for incident sustained VA [HR 1.4 (95% CI 1.1, 1.8)]. North Americans without ICDs were at higher risk for incident sustained VA [HR 2.1 (95% CI 1.3, 3.4)] than Europeans.Conclusions North American ARVC patients were substantially more likely than Europeans to receive primary prevention ICDs across all arrhythmic risk strata. A lower rate of ICD implantation in Europe was not associated with a higher rate of VA events in those without ICDs., Funding Agencies|Leonie-Wild Foundation; Leyla Erkan Family Fund for ARVD Research; Hugh Calkins, Marvin H. Weiner, and Jacqueline J. Bernstein Cardiac Arrhythmia Center; Dr Francis P. Chiaramonte Private Foundation; Dr Satish, Rupal, and Robin Shah ARVD Fund at Johns Hopkins; Bogle Foundation; Campanella Family; Patrick J. Harrison Family; Peter French Memorial Foundation; ALF foundation; Wilmerding Endowments; NIH [T32HL007227]; NIH Loan Repayment Program [L30HL165535]; Philippa and Marvin Carsley Cardiology Research Chair; Montreal Heart Institute Foundation; Norwegian Research Council [309762, 288438, 298736]; ZonMW Off Road personal research grant; Dutch Heart Association; Netherlands Cardiovascular Research Initiative - Dutch Heart Foundation [2018-30 PREDICT2]; Dutch Heart Foundation; Netherlands Heart Institute [06901]; Georg and Bertha Schwyzer-Winiker Foundation; Baugarten Foundation; Swiss National Science Foundation; Swiss Heart Foundation; USZ Foundation; Daniel Bravo Foundation; Spanish Society of Cardiology; Sociedad Espanola de Cardiologia; Swedish Heart Lung Foundation

Published
2024
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14. Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Team Onderzoek, Circulatory Health, Genetica, Genetica Groep Van Tintelen, Cancer, Child Health, Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, James, Cynthia A., Team Onderzoek, Circulatory Health, Genetica, Genetica Groep Van Tintelen, Cancer, Child Health, Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, and James, Cynthia A.

Published
2024

16. Pre- and post-procedural cardiac imaging (computed tomography and magnetic resonance imaging) in electrophysiology: a clinical consensus statement of the European Heart Rhythm Association and European Association of Cardiovascular Imaging of the European Society of Cardiology

Author

Deneke, Thomas, Kutyifa, Valentina, Hindricks, Gerhard, Sommer, Philipp, Zeppenfeld, Katja, Carbuccichio, Corrado, Pürerfellner, Helmut, Heinzel, Frank R, Traykov, Vassil B, Riva, Marta De, Pontone, Gianluca, Lehmkuhl, Lukas, Haugaa, Kristina, Sarkozy, Andrea, Gimelli, Alessia, Tondo, Claudio, Ernst, Sabine, Antz, Matthias, and Westwood, Mark

Abstract

Imaging using cardiac computed tomography (CT) or magnetic resonance (MR) imaging has become an important option for anatomic and substrate delineation in complex atrial fibrillation (AF) and ventricular tachycardia (VT) ablation procedures. Computed tomography more common than MR has been used to detect procedure-associated complications such as oesophageal, cerebral, and vascular injury. This clinical consensus statement summarizes the current knowledge of CT and MR to facilitate electrophysiological procedures, the current value of real-time integration of imaging-derived anatomy, and substrate information during the procedure and the current role of CT and MR in diagnosing relevant procedure-related complications. Practical advice on potential advantages of one imaging modality over the other is discussed for patients with implanted cardiac rhythm devices as well as for planning, intraprocedural integration, and post-interventional management in AF and VT ablation patients. Establishing a team of electrophysiologists and cardiac imaging specialists working on specific details of imaging for complex ablation procedures is key. Cardiac magnetic resonance (CMR) can safely be performed in most patients with implanted active cardiac devices. Standard procedures for pre- and post-scanning management of the device and potential CMR-associated device malfunctions need to be in place. In VT patients, imaging—specifically MR—may help to determine scar location and mural distribution in patients with ischaemic and non-ischaemic cardiomyopathy beyond evaluating the underlying structural heart disease. Future directions in imaging may include the ability to register multiple imaging modalities and novel high-resolution modalities, but also refinements of imaging-guided ablation strategies are expected. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Sex differences among subcutaneous implantable cardioverter-defibrillator recipients: a propensity-matched, multicentre, international analysis from the i-SUSI project.

Author

Schiavone, Marco, Gasperetti, Alessio, Vogler, Julia, Compagnucci, Paolo, Laredo, Mikael, Breitenstein, Alexander, Gulletta, Simone, Martinek, Martin, Kaiser, Lukas, Tundo, Fabrizio, Palmisano, Pietro, Rovaris, Giovanni, Curnis, Antonio, Kuschyk, Jürgen, Biffi, Mauro, Tilz, Roland, Biase, Luigi Di, Tondo, Claudio, Forleo, Giovanni B, and investigators, i-SUSI

Abstract

Aims Women have been historically underrepresented in implantable cardioverter-defibrillator (ICD) trials. No data on sex differences regarding subcutaneous ICDs (S-ICD) carriers have been described. Aim of our study was to investigate sex-related differences among unselected S-ICD recipients. Methods and results Consecutive patients enrolled in the multicentre, international i-SUSI registry were analysed. Comparisons between sexes were performed using a 1:1 propensity matching adjusted analysis for age, body mass index (BMI), left ventricular function, and substrate. The primary outcome was the rate of appropriate shocks during follow-up. Inappropriate shocks and other device-related complications were deemed secondary outcomes. A total of 1698 patients were extracted from the i-SUSI registry; 399 (23.5%) were females. After propensity matching, two cohorts of 374 patients presenting similar baseline characteristics were analysed. Despite similar periprocedural characteristics and a matched BMI, women resulted at lower risk of conversion failure as per PRAETORIAN score (73.4% vs. 81.3%, P = 0.049). Over a median follow-up time of 26.5 [12.7–42.5] months, appropriate shocks were more common in the male cohort (rate/year 3.4% vs. 1.7%; log-rank P = 0.049), while no significant differences in device-related complications (rate/year: 6.3% vs. 5.8%; log-rank P = 0.595) and inappropriate shocks (rate/year: 4.3% vs. 3.1%; log-rank P = 0.375) were observed. After controlling for confounders, sex remained significantly associated with the primary outcome (aHR 1.648; CI 0.999–2.655, P = 0.048), while not resulting predictor of inappropriate shocks and device-related complications. Conclusion In a propensity-matched cohort of S-ICD recipients, women are less likely to experience appropriate ICD therapy, while not showing higher risk of device-related complications. Clinical trial registration ClinicalTrials.gov Identifier: NCT0473876. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Practical Guide on Left Atrial Appendage Closure for the Non-implanting Physician. An International Consensus Paper

Author

Potpara, Tatjana, primary, Grygier, Marek, additional, Haeusler, Karl Georg, additional, Nielsen-Kudsk, Jens Erik, additional, Berti, Sergio, additional, Genovesi, Simonetta, additional, Marijon, Eloi, additional, Boveda, Serge, additional, Tzikas, Apostolos, additional, Boriani, Giuseppe, additional, Boersma, Lucas V A, additional, Tondo, Claudio, additional, De Potter, Tom, additional, Lip, Gregory Y H, additional, Schnabel, Renate B, additional, Bauersachs, Rupert, additional, Senzolo, Marco, additional, Basile, Carlo, additional, Bianchi, Stefano, additional, Osmancik, Pavel, additional, Schmidt, Boris, additional, Landmesser, Ulf, additional, Doehner, Wolfram, additional, Hindricks, Gerhard, additional, Kovac, Jan, additional, and Camm, A John, additional

Published
2024
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20. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Author

Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian-Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S. S. G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., and Reddy, Vivek Y.

Abstract

Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic palsy was reported (transient palsy was reported in 0.06% of patients; 11 of 17,642). Major complications, reported for ~1% of patients (173 of 17,642), were pericardial tamponade (0.36%; 63 of 17,642) and vascular events (0.30%; 53 of 17,642). Stroke was rare (0.12%; 22 of 17,642) and death was even rarer (0.03%; 5 of 17,642). Unexpected complications of PFA were coronary arterial spasm in 0.14% of patients (25 of 17,642) and hemolysis-related acute renal failure necessitating hemodialysis in 0.03% of patients (5 of 17,642). Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation. PFA has the potential to be transformative for the management of patients with AF.

Published
2024
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21. Intra-Cardiac versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion with a Watchman FLX Device

Author

Pastormerlo, Luigi Emilio, primary, Tondo, Claudio, additional, Fassini, Gaetano, additional, Nicosia, Antonino, additional, Ronco, Federico, additional, Contarini, Marco, additional, Giacchi, Giuseppe, additional, Grasso, Carmelo, additional, Casu, Gavino, additional, Romeo, Maria Rita, additional, Mazzone, Patrizio, additional, Limite, Luca, additional, Caramanno, Giuseppe, additional, Geraci, Salvatore, additional, Pagnotta, Paolo, additional, Chiarito, Mauro, additional, Tamburino, Corrado, additional, and Berti, Sergio, additional

Published
2023
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24. Bridging the gap in the symptomatic heart failure patient journey: insights from the Italian scenario

Author

Ziacchi, Matteo, primary, Spadotto, Alberto, additional, Ghio, Stefano, additional, Pellegrino, Marta, additional, Potena, Luciano, additional, Masarone, Daniele, additional, Merlo, Marco, additional, Stolfo, Davide, additional, Caracciolo, Maria Michela, additional, Inserra, Corinna, additional, Ammirati, Fabrizio, additional, Ciccarelli, Michele, additional, Colivicchi, Furio, additional, Bianchi, Stefano, additional, Patti, Giuseppe, additional, Oliva, Fabrizio, additional, Arcidiacono, Giuseppe, additional, Rordorf, Roberto, additional, Pini, Daniela, additional, Pacileo, Giuseppe, additional, D’Onofrio, Antonio, additional, Forleo, Giovanni Battista, additional, Mariani, Matteo, additional, Adamo, Francesco, additional, Alonzo, Alessandro, additional, Ruzzolini, Matteo, additional, Ghiglieno, Chiara, additional, Cipriani, Manlio, additional, Firetto, Giorgio, additional, Aspromonte, Nadia, additional, Clemenza, Francesco, additional, Maria De Ferrari, Gaetano, additional, Senni, Michele, additional, Grazia Bongiorni, Maria, additional, Tondo, Claudio, additional, Grimaldi, Massimo, additional, Giallauria, Francesco, additional, Rametta, Francesco, additional, Marchese, Procolo, additional, Biffi, Mauro, additional, and Sinagra, Gianfranco, additional

Published
2023
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25. Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion: The LAAO Italian Multicenter Registry

Author

Berti, Sergio, Pastormerlo, Luigi Emilio, Santoro, Gennaro, Brscic, Elvis, Montorfano, Matteo, Vignali, Luigi, Danna, Paolo, Tondo, Claudio, Rezzaghi, Marco, D’Amico, Gianpiero, Stabile, Amerigo, Saccà, Salvatore, Patti, Giuseppe, Rapacciuolo, Antonio, Poli, Arnaldo, Golino, Paolo, Magnavacchi, Paolo, Meucci, Francesco, Pezzulich, Bruno, Stolcova, Miroslava, and Tarantini, Giuseppe

Published
2018
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26. Omics Analyses of Stromal Cells from ACM Patients Reveal Alterations in Chromatin Organization and Mitochondrial Homeostasis

Author

Lippi, Melania, primary, Maione, Angela Serena, additional, Chiesa, Mattia, additional, Perrucci, Gianluca Lorenzo, additional, Iengo, Lara, additional, Sattin, Tommaso, additional, Cencioni, Chiara, additional, Savoia, Matteo, additional, Zeiher, Andreas M., additional, Tundo, Fabrizio, additional, Tondo, Claudio, additional, Pompilio, Giulio, additional, and Sommariva, Elena, additional

Published
2023
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27. Characteristics of Patients With Arrhythmogenic Left Ventricular Cardiomyopathy: Combining Genetic and Histopathologic Findings

Author

Casella, Michela, Gasperetti, Alessio, Sicuso, Rita, Conte, Edoardo, Catto, Valentina, Sommariva, Elena, Bergonti, Marco, Vettor, Giulia, Rizzo, Stefania, Pompilio, Giulio, Andreini, Daniele, Saguner, Ardan Muammer, Duru, Firat, Natale, Andrea, Thiene, Gaetano, Basso, Cristina, Dello Russo, Antonio, and Tondo, Claudio

Published
2020
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29. Pulmonary Vein Isolation With a Novel Multielectrode Radiofrequency Balloon Catheter That Allows Directionally Tailored Energy Delivery: Short-Term Outcomes From a Multicenter First-in-Human Study (RADIANCE)

Author

Reddy, Vivek Y., Schilling, Richard, Grimaldi, Massimo, Horton, Rodney, Natale, Andrea, Riva, Stefania, Tondo, Claudio, Kuck, Karl-Heinz, Neuzil, Petr, McInnis, Kendra, Bishara, Moe, Zhang, Baohui, Govari, Assaf, Abdelaal, Ahmed, and Mansour, Moussa

Published
2019
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30. Periprocedural outcome in patients undergoing left atrial appendage occlusion with the Watchman FLX device: The ITALIAN-FLX registry

Author

Berti, Sergio, primary, De Caterina, Alberto Ranieri, additional, Grasso, Carmelo, additional, Casu, Gavino, additional, Giacchi, Giuseppe, additional, Pagnotta, Paolo, additional, Maremmani, Michele, additional, Mazzone, Patrizio, additional, Limite, Luca, additional, Tomassini, Francesco, additional, Greco, Francesco, additional, Romeo, Maria Rita, additional, Caramanno, Giuseppe, additional, Fassini, Gaetano, additional, Geraci, Salvatore, additional, Chiarito, Mauro, additional, Tondo, Claudio, additional, Tamburino, Corrado, additional, and Contarini, Marco, additional

Published
2023
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32. Different Phases of Disease in Lymphocytic Myocarditis

Author

Casella, Michela, primary, Gasperetti, Alessio, additional, Compagnucci, Paolo, additional, Narducci, Maria Lucia, additional, Pelargonio, Gemma, additional, Catto, Valentina, additional, Carbucicchio, Corrado, additional, Bencardino, Gianluigi, additional, Conte, Edoardo, additional, Schicchi, Nicolò, additional, Andreini, Daniele, additional, Pontone, Gianluca, additional, Giovagnoni, Andrea, additional, Rizzo, Stefania, additional, Inzani, Frediano, additional, Basso, Cristina, additional, Natale, Andrea, additional, Tondo, Claudio, additional, Russo, Antonio Dello, additional, and Crea, Filippo, additional

Published
2023
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33. Non-invasive three-dimensional electrical activation mapping to predict cardiac resynchronization therapy response: site of latest left ventricular activation relative to pacing site

Author

Parreira, Leonor, primary, Tsyganov, Alexey, additional, Artyukhina, Elena, additional, Vernooy, Kevin, additional, Tondo, Claudio, additional, Adragao, Pedro, additional, Ascione, Ciro, additional, Carmo, Pedro, additional, Carvalho, Salomé, additional, Egger, Matthias, additional, Ferreira, Antonio, additional, Ghossein, Mohammed, additional, Holm, Magnus, additional, Kalinin, Vitaly, additional, Malakhova, Maria, additional, Meine, Mathias, additional, Nunes, Silvia, additional, Podolyak, Dmitry, additional, Revishvili, Amiran, additional, Shapieva, Albina, additional, Stepanova, Vera, additional, van Stipdonk, Antonius, additional, Taymasova, Irina, additional, Wouters, Philippe, additional, Zubarev, Stepan, additional, Leyva, Francisco, additional, Auricchio, Angelo, additional, and Varma, Niraj, additional

Published
2023
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34. Omics Analyses of Stromal Cells from ACM Patients Reveal Alterations in Chromatin Organization and Mitochondrial Homeostasis

Author

Lippi, M, Maione, A, Chiesa, M, Perrucci, G, Iengo, L, Sattin, T, Cencioni, C, Savoia, M, Zeiher, A, Tundo, F, Tondo, C, Pompilio, G, Sommariva, E, Lippi, Melania, Maione, Angela Serena, Chiesa, Mattia, Perrucci, Gianluca Lorenzo, Iengo, Lara, Sattin, Tommaso, Cencioni, Chiara, Savoia, Matteo, Zeiher, Andreas M, Tundo, Fabrizio, Tondo, Claudio, Pompilio, Giulio, Sommariva, Elena, Lippi, M, Maione, A, Chiesa, M, Perrucci, G, Iengo, L, Sattin, T, Cencioni, C, Savoia, M, Zeiher, A, Tundo, F, Tondo, C, Pompilio, G, Sommariva, E, Lippi, Melania, Maione, Angela Serena, Chiesa, Mattia, Perrucci, Gianluca Lorenzo, Iengo, Lara, Sattin, Tommaso, Cencioni, Chiara, Savoia, Matteo, Zeiher, Andreas M, Tundo, Fabrizio, Tondo, Claudio, Pompilio, Giulio, and Sommariva, Elena

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder characterized by ventricular arrhythmias, contractile dysfunctions and fibro-adipose replacement of myocardium. Cardiac mesenchymal stromal cells (CMSCs) participate in disease pathogenesis by differentiating towards adipocytes and myofibroblasts. Some altered pathways in ACM are known, but many are yet to be discovered. We aimed to enrich the understanding of ACM pathogenesis by comparing epigenetic and gene expression profiles of ACM-CMSCs with healthy control (HC)-CMSCs. Methylome analysis identified 74 differentially methylated nucleotides, most of them located on the mitochondrial genome. Transcriptome analysis revealed 327 genes that were more expressed and 202 genes that were less expressed in ACM- vs. HC-CMSCs. Among these, genes implicated in mitochondrial respiration and in epithelial-to-mesenchymal transition were more expressed, and cell cycle genes were less expressed in ACM- vs. HC-CMSCs. Through enrichment and gene network analyses, we identified differentially regulated pathways, some of which never associated with ACM, including mitochondrial functioning and chromatin organization, both in line with methylome results. Functional validations confirmed that ACM-CMSCs exhibited higher amounts of active mitochondria and ROS production, a lower proliferation rate and a more pronounced epicardial-to-mesenchymal transition compared to the controls. In conclusion, ACM-CMSC-omics revealed some additional altered molecular pathways, relevant in disease pathogenesis, which may constitute novel targets for specific therapies.

Published
2023

35. Non-invasive three-dimensional electrical activation mapping to predict cardiac resynchronization therapy response::site of latest left ventricular activation relative to pacing site

Author

Parreira, Leonor, Tsyganov, Alexey, Artyukhina, Elena, Vernooy, Kevin, Tondo, Claudio, Adragao, Pedro, Ascione, Ciro, Carmo, Pedro, Carvalho, Salomé, Egger, Matthias, Ferreira, Antonio, Ghossein, Mohammed, Holm, Magnus, Kalinin, Vitaly, Malakhova, Maria, Meine, Mathias, Nunes, Silvia, Podolyak, Dmitry, Revishvili, Amiran, Shapieva, Albina, Stepanova, Vera, van Stipdonk, Antonius, Taymasova, Irina, Wouters, Philippe, Zubarev, Stepan, Leyva, Francisco, Auricchio, Angelo, Varma, Niraj, Parreira, Leonor, Tsyganov, Alexey, Artyukhina, Elena, Vernooy, Kevin, Tondo, Claudio, Adragao, Pedro, Ascione, Ciro, Carmo, Pedro, Carvalho, Salomé, Egger, Matthias, Ferreira, Antonio, Ghossein, Mohammed, Holm, Magnus, Kalinin, Vitaly, Malakhova, Maria, Meine, Mathias, Nunes, Silvia, Podolyak, Dmitry, Revishvili, Amiran, Shapieva, Albina, Stepanova, Vera, van Stipdonk, Antonius, Taymasova, Irina, Wouters, Philippe, Zubarev, Stepan, Leyva, Francisco, Auricchio, Angelo, and Varma, Niraj

Abstract

AIMS: Pacing remote from the latest electrically activated site (LEAS) in the left ventricle (LV) may diminish response to cardiac resynchronization therapy (CRT). We tested whether proximity of LV pacing site (LVPS) to LEAS, determined by non-invasive three-dimensional electrical activation mapping [electrocardiographic Imaging (ECGI)], increased likelihood of CRT response. METHODS AND RESULTS: Consecutive CRT patients underwent ECGI and chest/heart computed tomography 6-24 months of post-implant. Latest electrically activated site and the distance to LVPS (dp) were assessed. Left ventricular end-systolic volume (LVESV) reduction of ≥15% at clinical follow-up defined response. Logistic regression probabilistically modelled non-response; variables included demographics, heart failure classification, left bundle branch block (LBBB), ischaemic heart disease (IHD), atrial fibrillation, QRS duration, baseline ejection fraction (EF) and LVESV, comorbidities, use of CRT optimization algorithm, angiotensin-converting enzyme inhibitor(ACE)/angiotensin-receptor blocker (ARB), beta-blocker, diuretics, and dp. Of 111 studied patients [64 ± 11 years, EF 28 ± 6%, implant duration 12 ± 5 months (mean ± SD), 98% had LBBB, 38% IHD], 67% responded at 10 ± 3 months post CRT-implant. Latest electrically activated sites were outside the mid-to-basal lateral segments in 35% of the patients. dp was 42 ± 23 mm [31 ± 14 mm for responders vs. 63 ± 24 mm non-responders (P < 0.001)]. Longer dp and the lack of use of CRT optimization algorithm were the only independent predictors of non-response [area under the curve (AUC) 0.906]. dp of 47 mm delineated responders and non-responders (AUC 0.931). CONCLUSION: The distance between LV pacing site and latest electrical activation is a strong independent predictor for CRT response. Non-invasive electrical evaluation to characterize intrinsic activation and guide LV lead deployment may improve CRT efficacy.

Published
2023

36. Individualized Family Screening for Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Team Onderzoek, Arts Assistenten Cardiologie, Onderzoek Precision medicine, Genetica Klinische Genetica, Circulatory Health, Gezonde Vaten, Genetica Groep Van Tintelen, Cancer, Child Health, Team Medisch, Muller, Steven A, Gasperetti, Alessio, Bosman, Laurens P, Schmidt, Amand F, Baas, Annette F, Amin, Ahmad S, Houweling, Arjan C, Wilde, Arthur A M, Compagnucci, Paolo, Targetti, Mattia, Casella, Michela, Calò, Leonardo, Tondo, Claudio, van der Harst, Pim, Asselbergs, Folkert W, van Tintelen, J Peter, Oerlemans, Marish I F J, Te Riele, Anneline S J M, Team Onderzoek, Arts Assistenten Cardiologie, Onderzoek Precision medicine, Genetica Klinische Genetica, Circulatory Health, Gezonde Vaten, Genetica Groep Van Tintelen, Cancer, Child Health, Team Medisch, Muller, Steven A, Gasperetti, Alessio, Bosman, Laurens P, Schmidt, Amand F, Baas, Annette F, Amin, Ahmad S, Houweling, Arjan C, Wilde, Arthur A M, Compagnucci, Paolo, Targetti, Mattia, Casella, Michela, Calò, Leonardo, Tondo, Claudio, van der Harst, Pim, Asselbergs, Folkert W, van Tintelen, J Peter, Oerlemans, Marish I F J, and Te Riele, Anneline S J M

Published
2023

37. Non-invasive three-dimensional electrical activation mapping to predict cardiac resynchronization therapy response: site of latest left ventricular activation relative to pacing site

Author

Team Medisch, Circulatory Health, Onderzoek Device, Parreira, Leonor, Tsyganov, Alexey, Artyukhina, Elena, Vernooy, Kevin, Tondo, Claudio, Adragao, Pedro, Ascione, Ciro, Carmo, Pedro, Carvalho, Salomé, Egger, Matthias, Ferreira, Antonio, Ghossein, Mohammed, Holm, Magnus, Kalinin, Vitaly, Malakhova, Maria, Meine, Mathias, Nunes, Silvia, Podolyak, Dmitry, Revishvili, Amiran, Shapieva, Albina, Stepanova, Vera, van Stipdonk, Antonius, Taymasova, Irina, Wouters, Philippe, Zubarev, Stepan, Leyva, Francisco, Auricchio, Angelo, Varma, Niraj, Team Medisch, Circulatory Health, Onderzoek Device, Parreira, Leonor, Tsyganov, Alexey, Artyukhina, Elena, Vernooy, Kevin, Tondo, Claudio, Adragao, Pedro, Ascione, Ciro, Carmo, Pedro, Carvalho, Salomé, Egger, Matthias, Ferreira, Antonio, Ghossein, Mohammed, Holm, Magnus, Kalinin, Vitaly, Malakhova, Maria, Meine, Mathias, Nunes, Silvia, Podolyak, Dmitry, Revishvili, Amiran, Shapieva, Albina, Stepanova, Vera, van Stipdonk, Antonius, Taymasova, Irina, Wouters, Philippe, Zubarev, Stepan, Leyva, Francisco, Auricchio, Angelo, and Varma, Niraj

Published
2023

40. Left ventricular functional recovery after atrial fibrillation catheter ablation in heart failure: a prediction model.

Author

Bergonti, Marco, Ascione, Ciro, Marcon, Lorenzo, Pambrun, Thomas, Rocca, Domenico G Della, Ferrero, Teba Gonzalez, Pannone, Luigi, Kühne, Michael, Compagnucci, Paolo, Bonomi, Alice, Gevaert, Andreas B, Anselmino, Matteo, Casella, Michela, Krisai, Philipp, Tondo, Claudio, Rodríguez-Mañero, Moises, Derval, Nicolas, Chierchia, Gian-Battista, Asmundis, Carlo de, and Heidbuchel, Hein

Subjects
HEART failure, ATRIAL flutter, ATRIAL fibrillation, CATHETER ablation, PREDICTION models, VENTRICULAR ejection fraction, VENTRICULAR remodeling
Abstract

Aims Management of patients with atrial fibrillation (AF) and concomitant heart failure (HF) remains complex. The Antwerp score, based on four parameters [QRS >120 ms (2 points), known aetiology (2 points), paroxysmal AF (1 point), severe atrial dilation (1 point)] adequately estimated the probability of left ventricular ejection fraction (LVEF) recovery after AF ablation in a single-centre cohort. The present study aims to externally validate this prediction model in a large European multi-centre cohort. Methods and results A total of 605 patients (61.1 ± 9.4 years, 23.8% females, 79.8% with persistent AF) with HF and impaired LVEF (<50%) undergoing AF ablation in 8 European centres were retrospectively identified. According to the LVEF changes at 12-month echocardiography, 427 (70%) patients fulfilled the '2021 Universal Definition of HF' criteria for LVEF recovery and were defined as 'responders'. External validation of the score yielded good discrimination and calibration {area under the curve 0.86 [95% confidence interval (CI) 0.82–0.89], P <.001; Hosmer–Lemeshow P =.29}. Patients with a score < 2 had a 93% probability of LVEF recovery as opposed to only 24% in patients with a score > 3. Responders experienced more often positive ventricular remodelling [odds ratio (OR) 8.91, 95% CI 4.45–17.84, P <.001], fewer HF hospitalizations (OR 0.09, 95% CI 0.05–0.18, P <.001) and lower mortality (OR 0.11, 95% CI 0.04–0.31, P <.001). Conclusion In this multi-centre study, a simple four-parameter score predicted LVEF recovery after AF ablation in patients with HF and discriminated clinical outcomes. These findings support the use of the Antwerp score to standardize shared decision-making regarding AF ablation referral in future clinical studies. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Inappropriate Shock Rates and Long-Term Complications due to Subcutaneous Implantable Cardioverter Defibrillators in Patients With and Without Heart Failure: Results From a Multicenter, International Registry

Author

Schiavone, Marco, primary, Gasperetti, Alessio, additional, Laredo, Mikael, additional, Breitenstein, Alexander, additional, Vogler, Julia, additional, Palmisano, Pietro, additional, Gulletta, Simone, additional, Pignalberi, Carlo, additional, Lavalle, Carlo, additional, Pisanò, Ennio, additional, Ricciardi, Danilo, additional, Curnis, Antonio, additional, Dello Russo, Antonio, additional, Tondo, Claudio, additional, Badenco, Nicolas, additional, Di Biase, Luigi, additional, Kuschyk, Jürgen, additional, Biffi, Mauro, additional, Tilz, Roland, additional, Forleo, Giovanni Battista, additional, Schiavone, M., additional, Gasperetti, A., additional, Arosio, R., additional, Ruggiero, D., additional, Viecca, M., additional, Forleo, G.B., additional, Ziacchi, M., additional, Diemberger, I., additional, Angeletti, A., additional, Biffi, M., additional, Fierro, N., additional, Gulletta, S., additional, Della Bella, P., additional, Tondo, C., additional, Mitacchione, G., additional, Curnis, A., additional, Compagnucci, P., additional, Casella, M., additional, Dello Russo, A., additional, Santini, L., additional, Pignalberi, C., additional, Piro, A., additional, Lavalle, C., additional, Picarelli, F., additional, Ricciardi, D., additional, Bressi, E., additional, Calò, L., additional, Montemerlo, E., additional, Rovaris, G., additional, De Bonis, S., additional, Bisignani, A., additional, Bisignani, G., additional, Russo, G., additional, Pisanò, E., additional, Palmisano, P., additional, Guarracini, F., additional, Vitali, F., additional, Bertini, M., additional, Vogler, J., additional, Fink, T., additional, Tilz, R., additional, Fastenrath, F., additional, Kuschyk, J., additional, Kaiser, L., additional, Hakmi, S., additional, Laredo, M., additional, Waintraub, X, additional, Gandjbakhch, E., additional, Badenco, N., additional, Breitenstein, A., additional, Saguner, A.M., additional, and Di Biase, L., additional

Published
2023
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42. Impact of Uncontrolled Hypertension on Atrial Fibrillation Ablation Outcome

Author

Santoro, Francesco, Di Biase, Luigi, Trivedi, Chintan, Burkhardt, John David, Paoletti Perini, Alessandro, Sanchez, Javier, Horton, Rodney, Mohanty, Prasant, Mohanty, Sanghamitra, Bai, Rong, Santangeli, Pasquale, Lakkireddy, Dhanunjay, Reddy, Madhu, Elayi, Claude Samy, Hongo, Richard, Beheiry, Salwa, Hao, Steven, Schweikert, Robert A., Viles-Gonzalez, Juan, Fassini, Gaetano, Casella, Michela, Dello Russo, Antonio, Tondo, Claudio, and Natale, Andrea

Published
2015
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43. Leadless Pacemaker Implantation in the Emergency Bradyarrhythmia Setting: Results from a Multicenter European Registry

Author

Schiavone, Marco, primary, Filtz, Annalisa, additional, Gasperetti, Alessio, additional, Breitenstein, Alexander, additional, Palmisano, Pietro, additional, Mitacchione, Gianfranco, additional, Gulletta, Simone, additional, Chierchia, Gian Battista, additional, Montemerlo, Elisabetta, additional, Statuto, Giovanni, additional, Russo, Giulia, additional, Casella, Michela, additional, Vitali, Francesco, additional, Mazzone, Patrizio, additional, Hofer, Daniel, additional, Arabia, Gianmarco, additional, Tundo, Fabrizio, additional, Ruggiero, Diego, additional, Fierro, Nicolai, additional, Moltrasio, Massimo, additional, Bertini, Matteo, additional, Dello Russo, Antonio, additional, Pisanò, Ennio C. L., additional, Della Bella, Paolo, additional, Rovaris, Giovanni, additional, de Asmundis, Carlo, additional, Biffi, Mauro, additional, Curnis, Antonio, additional, Tondo, Claudio, additional, Saguner, Ardan M., additional, and Forleo, Giovanni B., additional

Published
2022
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44. Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project

Author

Bertaglia, Emanuele, primary, Iacopino, Saverio, additional, Verlato, Roberto, additional, Arena, Giuseppe, additional, Pieragnoli, Paolo, additional, Tondo, Claudio, additional, Molon, Giulio, additional, Manfrin, Massimiliano, additional, Perego, Giovanni B., additional, Rovaris, Giovanni, additional, Rivezzi, Francesco, additional, Mantica, Massimo, additional, Startari, Umberto, additional, and Sciarra, Luigi, additional

Published
2022
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45. Ultra-high-resolution assessment of lesion extension after cryoballoon ablation for pulmonary vein isolation

Author

Spera, Francesco, primary, Narducci, Maria Lucia, additional, Bencardino, Gianluigi, additional, Perna, Francesco, additional, Bisignani, Antonio, additional, Pinnacchio, Gaetano, additional, Tondo, Claudio, additional, Maggio, Ruggero, additional, Stabile, Giuseppe, additional, Iacopino, Saverio, additional, Tundo, Fabrizio, additional, Ferraro, Anna, additional, De Simone, Antonio, additional, Malacrida, Maurizio, additional, Pintus, Federico, additional, Crea, Filippo, additional, and Pelargonio, Gemma, additional

Published
2022
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46. Programmed Ventricular Stimulation as an Additional Primary Prevention Risk Stratification Tool in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Study

Author

Gasperetti, Alessio, primary, Carrick, Richard T., additional, Costa, Sarah, additional, Compagnucci, Paolo, additional, Bosman, Laurens P., additional, Chivulescu, Monica, additional, Tichnell, Crystal, additional, Murray, Brittney, additional, Tandri, Harikrishna, additional, Tadros, Rafik, additional, Rivard, Lena, additional, van den Berg, Maarten P., additional, Zeppenfeld, Katja, additional, Wilde, Arthur A.M., additional, Pompilio, Giulio, additional, Carbucicchio, Corrado, additional, Dello Russo, Antonio, additional, Casella, Michela, additional, Svensson, Anneli, additional, Brunckhorst, Corinna B., additional, van Tintelen, J. Peter, additional, Platonov, Pyotr G., additional, Haugaa, Kristina H., additional, Duru, Firat, additional, te Riele, Anneline S.J.M., additional, Khairy, Paul, additional, Tondo, Claudio, additional, Calkins, Hugh, additional, James, Cynthia A., additional, Saguner, Ardan M., additional, and Cadrin-Tourigny, Julia, additional

Published
2022
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47. 929 LEADLESS PACEMAKER IMPLANTATION FOLLOWING TRANSVENOUS LEAD EXTRACTION: DATA FROM HIGH-VOLUME REFERRAL CENTERS

Author

Gianfranco Mitacchione, Marco Schiavone, Gianmarco Arabia, Alessio Gasperetti, Marialessia Denora, Roberto Arosio, Pietro Palmisano, Elisabetta Montemerlo, Cerini Manuel, Giulia Russo, Patrizio Mazzone, Matteo Ziacchi, Ennio Pisanò, Giovanni Rovaris, Simone Gulletta, Jan Steffel, Carlo De Asmundis, Alexander Breitenstein, Mauro Biffi, Giovanni Battista Chierchia, Antonio Dello Russo, Paolo Della Bella, Tondo Claudio, Giovanni Battista Forleo, and Antonio Curnis

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background limited data on real-world safety and efficacy of leadless pacemakers (LPMs) in patients who underwent transvenous lead extraction (TLE) are currently available. The present study aims to assess long-term safety and efficacy of LPMs implantation following TLE, compared with LPM de novo implant patients. Methods consecutive patients who underwent LPM implantation in 12 centers joining the International LEAdless PacemakEr (i-LEAPER) registry were enrolled end retrospectively considered. Patients receiving LPM following TLE (n=184) were compared with patients with de novo implant (n=995). The primary endpoint was LPM-related complications rate at implant and during follow-up (FU). Additionally, differences in electrical performance were assessed between the two groups. Results 1179 patients were enrolled in this study and followed for a median of 33 months. LPM related major complications and all-cause mortality did not differ among the two groups (1.6% TLE group vs. 2.2% de novo group, p=0.785, and 5.4% TLE group vs. 7.8% de novo group, p=0.288, respectively). Pacing threshold (PT) resulted higher in the TLE group throughout the whole follow-up (FU) (Figure 1). Higher PTs were recorded in LPMs implanted at same location from where the previous transvenous lead was removed, as far as 24-months postimplant (Figure 2), with a higher proportion of patients with high PT (>1 to 2V @0.24ms) in the first group at implant, 1-month, and 12-month FU (Figure 3). Conclusion In this real-world registry, LPMs showed a satisfactory safety and efficacy profile after TLE. In the post-TLE cohort, better electrical parameters were obtained when LPMs were implanted at a different location from where the previous transvenous lead was extracted.

Published
2022

48. Novel cryoballoon ablation system for pulmonary vein isolation: multicenter assessment of efficacy and safety—ANTARCTICA study

Author

Heeger, Christian-H, primary, Pott, Alexander, additional, Sohns, Christian, additional, Riesinger, Lisa, additional, Sommer, Philipp, additional, Gasperetti, Alessio, additional, Tondo, Claudio, additional, Fassini, Gaetano, additional, Moser, Fabian, additional, Lucas, Philipp, additional, Weinmann, Karolina, additional, Bohnen, Jan-Eric, additional, Dahme, Tillman, additional, Rillig, Andreas, additional, Kuck, Karl-Heinz, additional, Wakili, Reza, additional, Metzner, Andreas, additional, and Tilz, Roland R, additional

Published
2022
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