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5. A Multicenter Analysis of Short-term and Long-term Outcomes Following Laparoscopic Multivisceral Resection for Advanced Colorectal Cancer

Author

NAMBARA, SHO, primary, NAKANISHI, RYOTA, additional, NONAKA, KENTARO, additional, FUJIMOTO, YOSHIAKI, additional, HU, QINGJIANG, additional, NAKANOKO, TOMONORI, additional, SUGIYAMA, MASAHIKO, additional, OTA, MITSUHIKO, additional, KIMURA, YASUE, additional, OKI, EIJI, additional, TOH, YASUSHI, additional, and YOSHIZUMI, TOMOHARU, additional

Published
2024
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6. High Pretreatment Mean Corpuscular Volume Can Predict Worse Prognosis in Patients With Esophageal Squamous Cell Carcinoma who Have Undergone Curative Esophagectomy: A Retrospective Multicenter Cohort Study

Author

Yoshida, Naoya, Sasaki, Ken, Kanetaka, Kengo, Kimura, Yasue, Shibata, Tomotaka, Ikenoue, Makoto, Nakashima, Yuichiro, Sadanaga, Noriaki, Eto, Kojiro, Tsuruda, Yusuke, Kobayashi, Shinichiro, Nakanoko, Tomonori, Suzuki, Kosuke, Takeno, Shinsuke, Yamamoto, Manabu, Morita, Masaru, Toh, Yasushi, and Baba, Hideo

Published
2022
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7. A new scoring system with simple preoperative parameters as predictors of early recurrence of pancreatic ductal adenocarcinoma

Author

Shimagaki, Tomonari, primary, Sugimachi, Keishi, additional, Mano, Yohei, additional, Tomino, Takahiro, additional, Onishi, Emi, additional, Nakashima, Yuichiro, additional, Sugiyama, Masahiko, additional, Yamamoto, Manabu, additional, Morita, Masaru, additional, Shimokawa, Mototsugu, additional, Yoshizumi, Tomoharu, additional, and Toh, Yasushi, additional

Published
2023
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13. Persistent epigenetic alterations in transcription factors after a sustained virological response in hepatocellular carcinoma

Author

Sugimachi, Keishi, primary, Araki, Hiromitsu, additional, Saito, Hideyuki, additional, Masuda, Takaaki, additional, Miura, Fumihito, additional, Inoue, Kentaro, additional, Shimagaki, Tomonari, additional, Mano, Yohei, additional, Iguchi, Tomohiro, additional, Morita, Masaru, additional, Toh, Yasushi, additional, Yoshizumi, Tomoharu, additional, Ito, Takashi, additional, and Mimori, Koshi, additional

Published
2022
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18. Simple systemic index associated with oxaliplatin‐induced liver damage can be a novel biomarker to predict prognosis after resection of colorectal liver metastasis

Author

Shimagaki, Tomonari, primary, Sugimachi, Keishi, additional, Mano, Yohei, additional, Onishi, Emi, additional, Iguchi, Tomohiro, additional, Uehara, Hideo, additional, Sugiyama, Masahiko, additional, Yamamoto, Manabu, additional, Morita, Masaru, additional, and Toh, Yasushi, additional

Published
2022
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20. Thoracic and cardiovascular surgeries in Japan during 2018

Author

Shimizu, Hideyuki, Okada, Morihito, Toh, Yasushi, Doki, Yuichiro, Endo, Shunsuke, Fukuda, Hirotsugu, Hirata, Yasutaka, Iwata, Hisashi, Kobayashi, Junjiro, Kumamaru, Hiraku, Miyata, Hiroaki, Motomura, Noboru, Natsugoe, Shoji, Ozawa, Soji, Saiki, Yoshikatsu, Saito, Aya, Saji, Hisashi, Sato, Yukio, Taketani, Tsuyoshi, Tanemoto, Kazuo, Tangoku, Akira, Tatsuishi, Wataru, Tsukihara, Hiroyuki, Watanabe, Masayuki, Yamamoto, Hiroyuki, Minatoya, Kenji, Yokoi, Kohei, Okita, Yutaka, Tsuchida, Masanori, and Sawa, Yoshiki

Subjects
Annual Report
Published
2020

21. Primary tracheobronchial necrosis after esophagectomy: A nationwide multicenter retrospective study in Japan.

Author

Sakai, Makoto, Saeki, Hiroshi, Sohda, Makoto, Korematsu, Mizuki, Miyata, Hiroshi, Murakami, Daizo, Baba, Yoshifumi, Ishii, Ryo, Okamoto, Hiroshi, Shibata, Tomotaka, Shirabe, Ken, Toh, Yasushi, and Shiotani, Akihiro

Abstract

Background: The clinical features of postoperative primary tracheobronchial necrosis (P‐TBN; the necrosis without anastomotic leakage or other cervical and mediastinal abscess) remains unclear. This nationwide multicenter retrospective study first investigated the clinical features of P‐TBN after esophagectomy for upper aerodigestive tract cancer with a large cohort. Methods: As a study of the Japan Broncho‐Esophagological Society, a nationwide questionnaire survey was conducted in 67 institutions. The clinical data of 6370 patients who underwent esophagectomy for laryngeal, pharyngeal, and esophageal cancer between 2010 and 2019 were collected. Grades of P‐TBN were defined as follows: Grade 1, mucosal necrosis; Grade 2, transmural bronchial wall necrosis without fistula or perforation; Grade 3, transmural bronchial wall necrosis with fistula or perforation. Results: P‐TBN was observed in 48 (0.75%) of 6370 patients. The incidences of P‐TBN for pharyngo‐laryngo‐cervical esophagectomy (PLCE; n = 1650), total pharyngo‐laryngo‐esophagectomy (TPLE; n = 205), and subtotal esophagectomy (SE; n = 4515) were 2.0%, 5.4%, and 0.1%, respectively. The upper mediastinal LN dissection (P = 0.016) and the higher level of the tracheal resection (P = 0.039) were significantly associated with a higher grade of necrosis in PLCE and TPLE. Overall survival rates were significantly lower in patients with Grade 2 (P = 0.009) and Grade 3 (P = 0.004) than in those with Grade 1. Conclusion: The incidence of TBN restricted to P‐TBN was lower than previously reported. Maintaining the tracheal blood flow is essential to prevent worsening P‐TBN, especially in PLCE and TPLE. Our new P‐TBN severity grade may predict the outcome of patients with P‐TBN. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Thoracic and cardiovascular surgeries in Japan during 2017

Author

SATO, Yukio, Shimizu, Hideyuki, Okada, Morihito, Tangoku, Akira, Doki, Yuichiro, Endo, Shunsuke, Fukuda, Hirotsugu, Hirata, Yasutaka, Iwata, Hisashi, Kobayashi, Junjiro, Kumamaru, Hiraku, Miyata, Hiroaki, Motomura, Noboru, Natsugoe, Shoji, Ozawa, Soji, Saiki, Yoshikatsu, Saito, Aya, Saji, Hisashi, Taketani, Tsuyoshi, Tanemoto, Kazuo, Tatsuishi, Wataru, Toh, Yasushi, Tsukihara, Hiroyuki, Watanabe, Masayuki, Yamamoto, Hiroyuki, Yokoi, Kohei, and Okita, Yutaka

Published
2020

23. Prognosis of Patients with Esophageal Carcinoma following Routine Thoracic Duct Resection: A Propensity-matched Analysis of 12,237 Patients based on the Comprehensive Registry of Esophageal Cancer in Japan

Author

Oshikiri, Taro, Numasaki, Hodaka, Oguma, Junya, Toh, Yasushi, Watanabe, Masayuki, Muto, Manabu, Kakeji, Yoshihiro, and Doki, Yuichiro

Subjects
Mckeown esophagectomy, esophageal squamous cell carcinoma, thoracic duct
Abstract

Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. Summary Background Data: Although TD resection can cause nutritional disadvantage and immune suppression, it has been performed for the resection of surrounding lymph nodes. Methods: We analyzed 12,237 patients from the Comprehensive Registry of Esophageal Cancer in Japan who underwent esophagectomy between 2007 and 2012. TD resection and preservation groups were compared in terms of prognosis, perioperative outcomes, and initial recurrent patterns using strict propensity score matching. Particularly, the year of esophagectomy and history of primary cancer of other organs were added as covariates. Results: Following propensity score matching, 1638 c-Stage I–IV patients participated in each group. The five-year overall survival and cause-specific survival rates were 57.5% and 55.2% in the TD-resected group and 65.6% and 63.4% in the TD-preserved group, respectively, without significant differences. The TD-resected group had significantly more retrieved mediastinal nodes (30 vs. 21, P < 0.0001) and significantly fewer lymph node recurrence (376 vs. 450, P = 0.0029) compared with the TD-preserved group. However, the total number of distant metastatic organs was significantly greater in TD-resected group than in the TD-preserved group (499 vs. 421, P = 0.0024). Conclusions: TD resection did not improve survival in patients with esophageal cancer. Despite having retrieved more lymph nodes, TD resection caused distant metastases in more organs compared to TD preservation. Hence, prophylactic TD resection should not be recommended in patients with esophageal cancer.

Published
2021

24. A prognostic biomarker study in patients with clinical stage I esophageal squamous cell carcinoma: JCOG0502‐A1

Author

Oshima, Kotoe, primary, Kato, Ken, additional, Ito, Yoshinori, additional, Daiko, Hiroyuki, additional, Nozaki, Isao, additional, Nakagawa, Satoru, additional, Shibuya, Yuichi, additional, Kojima, Takashi, additional, Toh, Yasushi, additional, Okada, Morihito, additional, Hironaka, Shuichi, additional, Akiyama, Yuji, additional, Komatsu, Yoshito, additional, Maejima, Kazuhiro, additional, Nakagawa, Hidewaki, additional, Onuki, Ritsuko, additional, Nagai, Momoko, additional, Kato, Mamoru, additional, Kanato, Keisuke, additional, Kuchiba, Aya, additional, Nakamura, Kenichi, additional, and Kitagawa, Yuko, additional

Published
2021
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25. The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy

Author

Hirata, Hidenari, primary, Niida, Atsushi, additional, Kakiuchi, Nobuyuki, additional, Uchi, Ryutaro, additional, Sugimachi, Keishi, additional, Masuda, Takaaki, additional, Saito, Tomoko, additional, Kageyama, Shun-Ichiro, additional, Motomura, Yushi, additional, Ito, Shuhei, additional, Yoshitake, Tadamasa, additional, Tsurumaru, Daisuke, additional, Nishimuta, Yusuke, additional, Yokoyama, Akira, additional, Hasegawa, Takanori, additional, Chiba, Kenichi, additional, Shiraishi, Yuichi, additional, Du, Junyan, additional, Miura, Fumihito, additional, Morita, Masaru, additional, Toh, Yasushi, additional, Hirakawa, Masakazu, additional, Shioyama, Yoshiyuki, additional, Ito, Takashi, additional, Akimoto, Tetsuo, additional, Miyano, Satoru, additional, Shibata, Tatsuhiro, additional, Mori, Masaki, additional, Suzuki, Yutaka, additional, Ogawa, Seishi, additional, Ishigami, Kousei, additional, and Mimori, Koshi, additional

Published
2021
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28. Annual report by The Japanese Association for Thoracic Surgery

Author

Masuda, Munetaka, Endo, Shunsuke, Natsugoe, Shoji, Shimizu, Hideyuki, Doki, Yuichiro, Hirata, Yasutaka, Kobayashi, Junjiro, Motomura, Noboru, Nakano, Kiyoharu, Nishida, Hiroshi, Okada, Morihito, Saiki, Yoshikatsu, Saito, Aya, Sato, Yukio, Tanemoto, Kazuo, Toh, Yasushi, Tsukihara, Hiroyuki, Wakui, Shinji, Yokomise, Hiroyasu, Yokoi, Kohei, and Okita, Yutaka

Abstract

All data regarding cardiovascular surgery and thoracic surgery were obtained from NCD, whereas data regarding esophageal surgery were collected from survey questionnaire by The Japanese Association for Thoracic Surgery forms because NCD of esophageal surgery does not include non-surgical cases (i.e., patients with adjuvant chemotherapy or radiation alone). Based on the change in data aggregation, there are several differences between this 2015 annual report and previous annual reports: the number of institutions decreased in each category from 578 (2014) to 568 (2015) in cardiovascular, from 762 to 714 in general thoracic and from 626 to 571 in esophageal surgery. Because more than two departments in the same institute registered their data to NCD individually, we cannot calculate correct number of institutes in this survey. Then, the response rate is not indicated in the category of cardiovascular surgery (Table 1), and the number of institutions classified by the operation number is also not calculated in the category of cardiovascular surgery (Table 2).

Published
2018

36. Prognostic biomarker study in patients with clinical stage I esophageal squamous cell carcinoma: JCOG0502‐A1.

Author

Oshima, Kotoe, Kato, Ken, Ito, Yoshinori, Daiko, Hiroyuki, Nozaki, Isao, Nakagawa, Satoru, Shibuya, Yuichi, Kojima, Takashi, Toh, Yasushi, Okada, Morihito, Hironaka, Shuichi, Akiyama, Yuji, Komatsu, Yoshito, Maejima, Kazuhiro, Nakagawa, Hidewaki, Onuki, Ritsuko, Nagai, Momoko, Kato, Mamoru, Kanato, Keisuke, and Kuchiba, Aya

Abstract

We undertook genomic analyses of Japanese patients with stage I esophageal squamous cell carcinoma (ESCC) to investigate the frequency of genomic alterations and the association with survival outcomes. Biomarker analysis was carried out for patients with clinical stage T1bN0M0 ESCC enrolled in JCOG0502 (UMIN000000551). Whole‐exome sequencing (WES) was performed using DNA extracted from formalin‐fixed, paraffin‐embedded tissue of ESCC and normal tissue or blood sample. Single nucleotide variants (SNVs), insertions/deletions (indels), and copy number alterations (CNAs) were identified. We then evaluated the associations between each gene alteration with a frequency of 10% or more and progression‐free survival (PFS) using a Cox regression model. We controlled for family‐wise errors at 0.05 using the Bonferroni method. Among the 379 patients who were enrolled in JCOG0502, 127 patients were successfully analyzed using WES. The median patient age was 63 years (interquartile range, 57‐67 years), and 78.0% of the patients ultimately underwent surgery. The 3‐year PFS probability was 76.3%. We detected 20 genes with SNVs, indels, or amplifications with a frequency of 10% or more. Genomic alterations in FGF19 showed the strongest association with PFS with a borderline level of statistical significance of P =.00252 (Bonferroni‐adjusted significance level is.0025). Genomic alterations in FGF4, MYEOV, CTTN, and ORAOV1 showed a marginal association with PFS (P <.05). These genomic alterations were all CNAs at chromosome 11q13.3. We have identified new genomic alterations associated with the poor efficacy of ESCC (T1bN0M0). These findings open avenues for the development of new potential treatments for patients with ESCC. [ABSTRACT FROM AUTHOR]

Published
2022
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37. A Nationwide Survey on Digestive Reconstruction Following Pharyngolaryngectomy With Total Esophagectomy: A Multicenter Retrospective Study in Japan.

Author

Okamura, Akihiko, Watanabe, Masayuki, Mukoyama, Nobuaki, Ota, Yoshihiro, Shiraishi, Osamu, Shimbashi, Wataru, Baba, Yoshifumi, Matsui, Hidetoshi, Shinomiya, Hirotaka, Sugimura, Keijiro, Morita, Masaru, Sakai, Makoto, Sato, Hiroshi, Shibata, Tomotaka, Nasu, Motomi, Matsumoto, Shuichi, Toh, Yasushi, Shiotani, Akihiro, Kawata, Ryo, and Kishimoto, Yo

Abstract

Aim: Digestive reconstruction after pharyngolaryngectomy with total esophagectomy (PLTE) remains challenging, with the optimal method remaining unclear. The current study aimed to clarify the short‐term outcomes after PLTE and determine the optimal digestive reconstruction method. Methods: Based on a nationwide survey of 151 patients who underwent PLTE, outcomes of digestive reconstruction methods are described. Results: Among digestive reconstruction methods, a simple gastric tube was most frequently used (37.1%), followed by gastric tube combined with free graft transfer (FGT) (35.1%), gastric tube with microvascular anastomosis (22.5%), and other procedures (5.3%). Intraoperative evaluation of microcirculation (IOEM) was utilized in 29 patients (19.2%). Among the included patients, 66.9% developed any‐grade complications, 41.0% developed severe complications, and 23.8% developed digestive reconstruction‐related complications (DRRCs; leakage or necrosis). Reoperation within 30 days for any complications and DRRCs was required in 13.9% and 8.6% of the patients, respectively. Mortality within 90 days was observed in 4.6%. Among the three major methods, gastric tube combined with FGT promoted the least DRRCs in the gastric tube (P =.005), although the overall incidence of DRRCs was comparable. The use of IOEM was significantly associated with a reduction of severe DRRCs (P =.005). Conclusions: Pharyngolaryngectomy with total esophagectomy is a high‐risk surgery significantly associated with the occurrence of postoperative morbidity and mortality. Nonetheless, the addition of FGT can help prevent gastric tip complications, while IOEM can be an effective method for improving outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Prognostic Impact of Geriatric Nutritional Risk Index in Patients With Synchronous Colorectal Liver Metastasis

Author

IGUCHI, TOMOHIRO, primary, SUGIMACHI, KEISHI, additional, MANO, YOHEI, additional, MOTOMURA, TAKASHI, additional, SUGIYAMA, MASAHIKO, additional, OTA, MITSUHIKO, additional, IKEBE, MASAHIKO, additional, ESAKI, TAITO, additional, YOSHIZUMI, TOMOHARU, additional, MORITA, MASARU, additional, MORI, MASAKI, additional, and TOH, YASUSHI, additional

Published
2020
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40. Impact of adherence to board‐certified surgeon systems and clinical practice guidelines on colon cancer surgical outcomes in Japan: A questionnaire survey of the National Clinical Database

Author

Kobayashi, Hirotoshi, primary, Yamamoto, Hiroyuki, additional, Miyata, Hiroaki, additional, Gotoh, Mitsukazu, additional, Kotake, Kenjiro, additional, Sugihara, Kenichi, additional, Toh, Yasushi, additional, Kakeji, Yoshihiro, additional, and Seto, Yasuyuki, additional

Published
2020
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41. The Preoperative Prognostic Nutritional Index Predicts the Development of Deep Venous Thrombosis After Pancreatic Surgery

Author

IGUCHI, TOMOHIRO, primary, SUGIMACHI, KEISHI, additional, MANO, YOHEI, additional, KONO, MIHOKO, additional, KAGAWA, MASAKI, additional, NAKANOKO, TOMONORI, additional, UEHARA, HIDEO, additional, SUGIYAMA, MASAHIKO, additional, OTA, MITSUHIKO, additional, IKEBE, MASAHIKO, additional, MORITA, MASARU, additional, and TOH, YASUSHI, additional

Published
2020
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42. Laparoscopic Total Gastrectomy for Remnant Gastric Cancer: A Single-institution Experience and Systematic Literature Review

Author

OTA, MITSUHIKO, primary, IKEBE, MASAHIKO, additional, SHIN, YUKI, additional, KAGAWA, MASAKI, additional, MANO, YOHEI, additional, NAKANOKO, TOMONORI, additional, NAKASHIMA, YUICHIRO, additional, UEHARA, HIDEO, additional, SUGIYAMA, MASAHIKO, additional, IGUCHI, TOMOHIRO, additional, SUGIMACHI, KEISHI, additional, YAMAMOTO, MANABU, additional, MORITA, MASARU, additional, and TOH, YASUSHI, additional

Published
2020
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45. Characteristics of the Salivary Microbiota in Patients With Various Digestive Tract Cancers

Author

Kageyama, Shinya, primary, Takeshita, Toru, additional, Takeuchi, Kenji, additional, Asakawa, Mikari, additional, Matsumi, Rie, additional, Furuta, Michiko, additional, Shibata, Yukie, additional, Nagai, Kiyoshi, additional, Ikebe, Masahiko, additional, Morita, Masaru, additional, Masuda, Muneyuki, additional, Toh, Yasushi, additional, Kiyohara, Yutaka, additional, Ninomiya, Toshiharu, additional, and Yamashita, Yoshihisa, additional

Published
2019
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46. Totally Laparoscopic Distal Gastrectomy for Elderly Patients with Gastric Cancer

Author

Oki, Eiji, Sakaguchi, Yoshihisa, Ohgaki, Kippei, Saeki, Hiroshi, Ikegami, Toru, Minami, Kazuhito, Yamashita, Yoichi, Toh, Yasushi, Soejima, Yuji, Ando, Koji, Mimori, Koshi, Watanabe, Masayuki, Sugimachi, Keishi, Uchiyama, Hideaki, Yoshizumi, Tomoharu, Kawanaka, Hirofumi, Morita, Masaru, Ikeda, Tetsuo, and Maehara, Yoshihiko

Subjects
Elderly, Laparoscopic gastrectomy, Gastric cancer, humanities
Abstract

Introduction : This study evaluated the feasibility of totally laparoscopic distal gastrectomy (TLDG) in elderly patients with gastric cancer. Methods : We retrospectively analyzed the data from 138 patients who underwent TLDG from April 2005 to March 2009. Of these 138 patients, 20 were older than 75 years of age, and 118 were 75 years of age or younger. Results : The preoperative respiratory function and American Society of Anesthesiologists (ASA) -physical status were significantly worse in the elderly patients than in the younger patients (P =0.013). Hypertension and respiratory disease were more common in the elderly patients than in the younger patients (P = 0.032/0.005). The findings for the following parameters were similar in the two groups : intraoperative blood loss, operation time, severe postoperative complication rate, time required to start a solid diet, and duration of postoperative hospital stay. The rate of major complications was not different between the two groups, although minor complications were more commonly observed in the elderly patients. Conclusion : TLDG was found to be a safe procedure for elderly patients. This method can be used as one of the standard treatments for gastric cancer in elderly patients., 【はじめに】高齢者に対する腹腔鏡下幽門側胃切除術（以下TLDG）の安全性とその有用性は確立されていない. 本論文では, 76歳以上の高齢者に対するTLDG の安全性と有効性を75 歳以下の症例と比較検討した. 【症例】2005 年4 月〜2009 年3 月までの間に行われた完全鏡視下幽門側胃切除138例のうち, 76 歳以上20例と75 歳以下の118 例について, 術中・術後合併症, 術後経過などについて比較した. 【結果】術前のASA status は高齢者群で有意に悪く（P＝ 0.013）, 高血圧と呼吸疾患の合併は高齢者で多かった（P＝ 0.032/P＝ 0.005）. 術中の出血量や手術時間, 入院日数などに両者の違いはなかった. 術後合併症は, 重症なものは両者に違いはなかったが, 創感染など軽微なものが高齢者に多かった. 術後1 年後の体重減少率や血液データなどに両者の違いは認められなかった. 【結語】背景因子には違いはあるが, 高齢者のTLDG は若年者と変わらず安全に施行可能であると考えられる.

Published
2013

47. Phase II study of S‐1 plus leucovorin in patients with metastatic colorectal cancer: Regimen of 1 week on, 1 week off

Author

Li, Jin, primary, Xu, Ruihua, additional, Xu, Jianming, additional, Denda, Tadamichi, additional, Ikejiri, Koji, additional, Shen, Lin, additional, Toh, Yasushi, additional, Shimada, Ken, additional, Kato, Takeshi, additional, Sakai, Kenji, additional, Yamamoto, Manabu, additional, Mishima, Hideyuki, additional, Wang, Jinwan, additional, and Baba, Hideo, additional

Published
2017
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50. Current Treatment and Application of Hyperthermia for Squamous Cell Carcinoma of the Esophagus

Author

MORITA, MASARU, primary, IKEBE, MASAHIKO, additional, KAGAWA, MASAKI, additional, NAKAJI, YU, additional, SUGIYAMA, MASAHIKO, additional, YOSHIDA, DAISUKE, additional, OTA, MITSUHIKO, additional, IGUCHI, TOMOHIRO, additional, SUGIMACHI, KEISHI, additional, KUNITAKE, NAONOBU, additional, SAEKI, HIROSHI, additional, OKI, EIJI, additional, OHGA, SAIJI, additional, TOH, YASUSHI, additional, and MAEHARA, YOSHIHIKO, additional

Published
2017
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