188 results on '"Tinazzi M"'
Search Results
2. Phenotypic Variability in Acquired and Idiopathic Dystonia
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Defazio, G, Gigante, Af, Erro, R, Belvisi, D, Esposito, M, Trinchillo, A, De Joanna, G, Ceravolo, R, Mazzucchi, S, Unti, E, Barone, P, Scannapieco, S, Cotelli, Ms, Turla, M, Bianchi, M, Bertolasi, L, Pisani, A, Valentino, F, Altavista, Mc, Moschella, V, Girlanda, P, Terranova, C, Bono, F, Spano, G, Fabbrini, G, Ferrazzano, G, Albanese, A, Castagna, A, Cassano, D, Moja, Mc, Pellicciari, R, Bentivoglio, Ar, Eleopra, R, Cossu, G, Ercoli, T, Mascia, Mm, Di Biasio, F, Misceo, S, Magistrelli, L, Romano, M, Scaglione, Clm, Tinazzi, M, Maderna, L, Zibetti, M, and Berardelli, A
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clinical phenomenology ,acquired ,idiopathic ,dystonia - Published
- 2023
3. Axial postural abnormalities in Parkinsonism: gaps in predictors, pathophysiology, and management
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Geroin, C., Artusi, C.A., Nonnekes, J.H., Aquino, C., Garg, D., Dale, M.L., Schlosser, D., Lai, Y., Al-Wardat, M., Salari, M., Wolke, R., Labou, V.T., Imbalzano, G., Camozzi, S., Merello, M., Bloem, B.R., Capato, T., Djaldetti, R., Doherty, K., Fasano, A., Tibar, H., Lopiano, L., Margraf, N.G., Moreau, C., Ugawa, Y., Bhidayasiri, R., and Tinazzi, M.
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Pisa syndrome ,postural abnormalities ,All institutes and research themes of the Radboud University Medical Center ,camptocormia ,clinical predictors ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,antecollis ,parkinsonism ,pathophysiology - Abstract
Contains fulltext : 293771.pdf (Publisher’s version ) (Open Access)
- Published
- 2023
4. A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial
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Abbruzzese, G., Kulisevsky, J., Bergmans, B., Gomez-Esteban, J. C., Kagi, G., Raw, J., Stefani, A., Warnecke, T., Jost, W. H., Bourgeois, P., Cras, P., de Klippel, N., Dethy, S., Franco, G., Garraux, G., Geens, K., Jacquerye, P., Jeanjean, A., Santens, P., Supiot, F., van der Linden, C., Blersch, W. K., Delf, M., Hellwig, B., Herbst, H. P., Kupsch, A., Lang, M., Muhlack, S., Nastos, I., Oehlwein, C., Schlegel, E., Schwarz, J., Woitalla, D., Aguggia, M., Avarello, T., Barone, P., Baruffaldi, R., Belgrado, E., Bentivoglio, A. R., Bosco, D., Calabresi, P., Callegarini, C., Cannas, A., Centonze, D., Ceravolo, R., Colosimo, C., Comi, C., Contardi, S., Cortelli, P., Cossu, G., D'Amelio, M., de Pandis, M. F., Denaro, A., Di Lazzaro, V., Fabbrini, G., Gasparoli, E., Guidi, M., Iliceto, G., Lopiano, L., Manganotti, P., Marconi, R., Marini, C., Marsala, S. Z., Mauri, M., Moleri, M., Monge, A., Morgante, F., Negrotti, A., Nordera, G., Onofrj, M., Pacchetti, C., Padovani, A., Pontieri, F. E., Priori, A., Quatrale, R., Sensi, M., Tamma, F., Tessitore, A., Tinazzi, M., Vitale, C., Volonte, M. A., Zappia, M., Zecchinelli, A. L., Arbelo Gonzalez, J. M., Bayes, A., Blazquez, M., Calopa Garriga, M., Callen, A., Campos Arillo, V., Cubo, E., de Fabregues, O., Escalante Arroyo, S., Espinosa Rosso, R., Esquivel Lopez, A., Freire, E., Garcia Cobos, E., Garcia Moreno, J. M., Gonzalez-Ardura, J., Grandas Perez, F., Kurtis, M., Juni, J., Legarda, I., Leiva, C., Lopez Aristegui, N., Lopez Manzanares, L., Lozano, J. J., Luquin, M. R., Martinez Castrillo, J. C., Marti Domenech, M. J., Martinez, I., Mata, M., Mir Rivera, P., Pascual Sedano, B., Rodriguez Oroz, M. C., Rodriguez Uranga, J. J., Sanchez, S., Santos Garcia, D., Solano, B., Vaamonde Gamo, J., Accolla, E., Bohlhalter, S., Kalin, A., Michelis, J., Carrol, C., Henderson, E., Raha, S., Silva, N., Silverdale, M., Universidad de Sevilla. Departamento de Medicina, Abbruzzese G., Kulisevsky J., Bergmans B., Gomez-Esteban J.C., Kagi G., Raw J., Stefani A., Warnecke T., Jost W.H., Bourgeois P., Cras P., de Klippel N., Dethy S., Franco G., Garraux G., Geens K., Jacquerye P., Jeanjean A., Santens P., Supiot F., van der Linden C., Blersch W.K., Delf M., Hellwig B., Herbst H.P., Kupsch A., Lang M., Muhlack S., Nastos I., Oehlwein C., Schlegel E., Schwarz J., Woitalla D., Aguggia M., Avarello T., Barone P., Baruffaldi R., Belgrado E., Bentivoglio A.R., Bosco D., Calabresi P., Callegarini C., Cannas A., Centonze D., Ceravolo R., Colosimo C., Comi C., Contardi S., Cortelli P., Cossu G., D'Amelio M., de Pandis M.F., Denaro A., Di Lazzaro V., Fabbrini G., Gasparoli E., Guidi M., Iliceto G., Lopiano L., Manganotti P., Marconi R., Marini C., Marsala S.Z., Mauri M., Moleri M., Monge A., Morgante F., Negrotti A., Nordera G., Onofrj M., Pacchetti C., Padovani A., Pontieri F.E., Priori A., Quatrale R., Sensi M., Tamma F., Tessitore A., Tinazzi M., Vitale C., Volonte M.A., Zappia M., Zecchinelli A.L., Arbelo Gonzalez J.M., Bayes A., Blazquez M., Calopa Garriga M., Callen A., Campos Arillo V., Cubo E., de Fabregues O., Escalante Arroyo S., Espinosa Rosso R., Esquivel Lopez A., Freire E., Garcia Cobos E., Garcia Moreno J.M., Gonzalez-Ardura J., Grandas Perez F., Kurtis M., Juni J., Legarda I., Leiva C., Lopez Aristegui N., Lopez Manzanares L., Lozano J.J., Luquin M.R., Martinez Castrillo J.C., Marti Domenech M.J., Martinez I., Mata M., Mir Rivera P., Pascual Sedano B., Rodriguez Oroz M.C., Rodriguez Uranga J.J., Sanchez S., Santos Garcia D., Solano B., Vaamonde Gamo J., Accolla E., Bohlhalter S., Kalin A., Michelis J., Carrol C., Henderson E., Raha S., Silva N., and Silverdale M.
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Research Report ,Male ,0301 basic medicine ,Benzylamines ,Parkinson's disease ,Outcome Assessment ,Comorbidity ,Disease ,Real-life evaluation ,chemistry.chemical_compound ,0302 clinical medicine ,Outcome Assessment, Health Care ,80 and over ,MAO-B inhibitor ,Aged, 80 and over ,Safinamide ,education.field_of_study ,Alanine ,Mental Disorders ,Parkinson Disease ,Middle Aged ,Aged ,Drug-Related Side Effects and Adverse Reactions ,Europe ,Female ,Follow-Up Studies ,Humans ,Monoamine Oxidase Inhibitors ,Retrospective Studies ,Settore MED/26 - NEUROLOGIA ,Erratum ,Cohort study ,medicine.medical_specialty ,Population ,MEDLINE ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Internal medicine ,medicine ,Adverse effect ,education ,business.industry ,medicine.disease ,Health Care ,030104 developmental biology ,chemistry ,Parkinson’s disease ,Observational study ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background: Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor symptoms of Parkinson's disease (PD). The drug utilization study SYNAPSES was designed to investigate the use of safinamide in routine clinical practice, as recommended by the European Medicines Agency. Objective: To describe the occurrence of adverse events in PD patients treated with safinamide in real-life conditions. Methods: The SYNAPSES trial is an observational, European, multicenter, retrospective-prospective cohort study. Patients were followed up to 12 months with analyses performed in the overall population and in patients aged >75 years, with relevant comorbidities and with psychiatric conditions. Results: Of the 1610 patients included, 82.4% were evaluable after 12 months with 25.1% of patients >75 years, 70.8% with relevant comorbidities and 42.4% with psychiatric conditions. During observation 45.8% patients experienced adverse events, 27.7% patients had adverse drug reactions and 9.2% patients had serious adverse events. The adverse events were those already described in the patients' information leaflet. The majority were mild or moderate and completely resolved and no differences were detected between the subgroup of patients. Clinically significant improvements were seen in the UPDRS motor score and in the UPDRS total score in >= 40% of patients, according to the criteria developed by Shulman et al. Conclusion: The SYNAPSES study confirms the good safety profile of safinamide even in special groups of patients. Motor complications and motor scores improved with clinically significant results in the UPDRS scale maintained in the long-term.
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- 2022
5. The role of glutamatergic neurotransmission in the motor and non-motor symptoms in Parkinson's disease: Clinical cases and a review of the literature
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Pagonabarraga, J, Tinazzi, M, Caccia, C, and Jost, WH
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Parkinson disease ,Case reports ,Safinamide ,Glutamic acid - Abstract
Glutamate is the major excitatory neurotransmitter in the central nervous system and, as such, many brain regions, including the basal ganglia, are rich in glutamatergic neurons. The importance of the basal ganglia in the control of voluntary movement has long been recognised, with the effect of dysfunction of the region exemplified by the motor symptoms seen in Parkinson's disease (PD). However, the basal gan-glia and the associated glutamatergic system also play a role in the modulation of emotion, nociception and cognition, dysregulation of which result in some of the non-motor symptoms of PD (depression/anx-iety, pain and cognitive deficits). Thus, while the treatment of PD has traditionally been approached from the perspective of dopaminergic replacement, using agents such as levodopa and dopamine receptor ago-nists, the glutamatergic system offers a novel treatment target for the disease. Safinamide has been approved in over 20 countries globally for fluctuating PD as add-on therapy to levodopa regimens for the management of 'off' episodes. The drug has both dopaminergic and non-dopaminergic pharmacolog-ical effects, the latter including inhibition of abnormal glutamate release. The effect of safinamide on the glutamatergic system might present some advantages over dopamine-based therapies for PD by provid-ing efficacy for motor (levodopa-induced dyskinesia) as well as non-motor (anxiety, mood disorders, pain) symptoms. In this article, we discuss the potential role of glutamatergic inhibition on these symp-toms, using illustrative real-world examples of patients we have treated with safinamide. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
- Published
- 2021
6. From DYMUS to DYPARK: Validation of a Screening Questionnaire for Dysphagia in Parkinson's Disease
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Dagna, Carlotta, Avenali, Micol, De Icco, Roberto, Gandolfi, Marialuisa, Solaro, Claudio, Restivo, Domenico, Bartolo, Michelangelo, Meneghello, Francesca, Sandrini, Giorgio, Tassorelli, Cristina, DYPARK SIRN Group:, M Berlangieri, Cristina, S, Alfonsi, E, Monti, E, Bertino, G, Tinazzi, M, Busselli, G, C De Paoli, Smania, N, Inglese, K, S De Santi, Taiocchi, N, Zucchelli, B, Ronzoni, G, Nordio, S, and Tonin, P
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medicine.medical_specialty ,Multiple Sclerosis ,Sensitivity and Specificity ,03 medical and health sciences ,Speech and Hearing ,0302 clinical medicine ,Swallowing ,Cronbach's alpha ,Internal medicine ,Surveys and Questionnaires ,otorhinolaryngologic diseases ,medicine ,Humans ,030223 otorhinolaryngology ,business.industry ,Swallowing Disorders ,Gastroenterology ,Area under the curve ,Parkinson Disease ,Dysphagia ,Hepatology ,Deglutition ,Otorhinolaryngology ,Parkinson’s disease ,Screening ,Observational study ,medicine.symptom ,business ,Deglutition Disorders ,030217 neurology & neurosurgery - Abstract
Dysphagia is a common debilitating symptom in people with Parkinson’s Disease (PD), adequate screening of swallowing disorders is fundamental. The DYMUS questionnaire has shown very good characteristics for the screening of dysphagia in Multiple Sclerosis, and it might also prove useful for screening dysphagia in PD. The primary aim was to test and validate the DYMUS questionnaire in PD patients. This is an observational multicentric study involving 103 patients affected by PD. All subjects filled in the DYMUS and the Eating Assessment Tool (EAT-10) questionnaires. A subgroup of patients (n = 53) underwent a fiber-optic endoscopic evaluation of swallowing (FEES) and their dysphagia was scored by means of the Dysphagia Outcome Severity Scale (DOSS). DYMUS showed a relatively high level of internal consistency (Cronbach’s alpha 0.79). A significant positive correlation was found between the DYMUS and the EAT-10 scores (p p p
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- 2020
7. Il disturbo neurologico motorio funzionale: un quid novi nella cultura medico legale
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Colombari, M., Gandolfi, M. L., Turrina, S., Tinazzi, M., and De Leo, D.
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medicina legale ,disturbo motorio funzionale ,disturbo neurologico funzionale ,tutela sociale - Published
- 2020
8. Hiding in plain sight: Functional neurological disorders in the news
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Popkirov, S. Nicholson, T.R. Bloem, B.R. Cock, H.R. Derry, C.P. Duncan, R. Dworetzky, B.A. Edwards, M.J. Espay, A.J. Hallett, M. Lang, A.E. Leach, J.P. Lehn, A. McGonigal, A. Morgante, F. Perez, D.L. Reuber, M. Richardson, M.P. Smith, P. Stamelou, M. Tijssen, M.A.J. Tinazzi, M. Carson, A.J. Stone, J.
- Abstract
Objective: Functional movement and seizure disorders are still widely misunderstood and receive little public and academic attention. This is in stark contrast to their high prevalence and levels of associated disability. In an exploratory observational study, the authors examined whether the relative lack of media coverage of functional neurological disorders is in part due to misidentification in “human in-terest” news stories. Methods: Thirteen recent news stories from high-impact English-language media outlets that portrayed patients with complex symptoms either attributed to other diagnoses or presented as medical mysteries were identified using online keyword searches. All selected news stories contained video or still images displaying relevant symptoms. Cases were categorized into movement disorders or seizure disorders and were then independently assessed by 10 respective expert raters. For each category, one story of a patient whose symptoms were due to a well-recognized neurological disease was also included. Both the diagnostic category and the respective confidence level were reported by each rater for each case. The interrater agreement was calculated for each group of disorders. Results: The raters confirmed almost unanimously that all presented news stories except the negative control cases portrayed misidentified functional movement or seizure disorders. The interrater agreement and average diagnostic confidence were high. Conclusions: Functional neurological disorders are often wrongly considered a rare medical curiosity of the past. However, these findings suggest that, while they are largely absent from public discourse, they often appear in the news incognito, hiding in plain sight. © 2019, American Psychiatric Association. All rights reserved.
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- 2019
9. PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology
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Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J, Netherlands Brain Bank, International Parkinsonism Genetics Network, Ferreira J, Correia Guedes L, Chien HF, Barbosa ER, Merola A, Zibetti M, Lopiano L, Tassorelli C, Pacchetti C, Nappi G, Riboldazzi G, Bono G, Padovani A, Borroni B, Fincati E, Bertolasi L, Tinazzi M, Bonizzato A, Dalla Libera A, Guidi M, Marini P, Massaro F, Marconi R, Onofrj M, Thomas A, Vanacore N, Meco G, Fabbrini G, Fabrizio E, Manfredi M, Berardelli A, Stocchi F, Vacca L, De Mari M, Dell'Aquila C, Iliceto G, Lamberti P, Toni V, Trianni G, Saddi V, Cossu G, Melis M., CORTELLI, PIETRO, CAPELLARI, SABINA, Pathology, Human genetics, Neurology, NCA - neurodegeneration, Clinical Genetics, Internal Medicine, Molecular Genetics, Obstetrics & Gynecology, Molecular and Cellular Neurobiology, Neuroscience Campus Amsterdam - Neurodegeneration, AIMMS, Netherlands Institute for Neuroscience (NIN), Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J, Netherlands Brain Bank, International Parkinsonism Genetics Network, Ferreira J, Correia Guedes L, Chien HF, Barbosa ER, Merola A, Zibetti M, Lopiano L, Tassorelli C, Pacchetti C, Nappi G, Riboldazzi G, Bono G, Padovani A, Borroni B, Fincati E, Bertolasi L, Tinazzi M, Bonizzato A, Dalla Libera A, Cortelli P, Capellari S, Guidi M, Marini P, Massaro F, Marconi R, Onofrj M, Thomas A, Vanacore N, Meco G, Fabbrini G, Fabrizio E, Manfredi M, Berardelli A, Stocchi F, Vacca L, De Mari M, Dell'Aquila C, Iliceto G, Lamberti P, Toni V, Trianni G, Saddi V, Cossu G, and Melis M
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Models, Molecular ,Male ,Electron Microscope Tomography ,Pathology ,neurofilament ,metabolism [Cyclic AMP-Dependent Protein Kinase Catalytic Subunits] ,pathology [Frontal Lobe] ,0302 clinical medicine ,chemistry [Cyclic AMP-Dependent Protein Kinase Catalytic Subunits] ,Models ,Missense mutation ,metabolism [alpha-Synuclein] ,Intermediate filament ,0303 health sciences ,Parkinsonism ,pathology [Neurodegenerative Diseases] ,Neurodegenerative Diseases ,Single Nucleotide ,SDG 10 - Reduced Inequalities ,Middle Aged ,Frontal Lobe ,3. Good health ,DNA-Binding Proteins ,genetics [Cyclic AMP-Dependent Protein Kinase RIbeta Subunit] ,metabolism [Frontal Lobe] ,PRKAR1B ,neurodegenerative disorders ,genetics [Polymorphism, Single Nucleotide] ,alpha-Synuclein ,Female ,metabolism [DNA-Binding Proteins] ,Frontotemporal dementia ,medicine.medical_specialty ,Neurofilament ,Protein subunit ,metabolism [Amyloid beta-Peptides] ,Nerve Tissue Proteins ,tau Proteins ,Biology ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,medicine ,Humans ,ddc:610 ,Polymorphism ,Protein kinase A ,Hereditary Neurodegenerative Disorder ,Genetic Association Studies ,Aged ,030304 developmental biology ,Family Health ,intermediate filament ,Cyclic AMP-Dependent Protein Kinase Catalytic Subunits ,metabolism [Nerve Tissue Proteins] ,Amyloid beta-Peptides ,protein kinase A Calpha ,protein kinase A ,Molecular ,medicine.disease ,Molecular biology ,metabolism [tau Proteins] ,ultrastructure [Frontal Lobe] ,PRKAR1B protein, human ,genetics [Neurodegenerative Diseases] ,Parkinson’s disease ,Cyclic AMP-Dependent Protein Kinase RIbeta Subunit ,Neurology (clinical) ,030217 neurology & neurosurgery - Abstract
Inclusions of intermediate filaments are found in a number of neurodegenerative diseases. Using whole exome sequencing, linkage analysis and proteomics, Wong and Chiu et al. identify a new familial neurodegenerative disease with intermediate filament inclusions, linked to a mutation in the gene encoding the PKA type I-beta regulatory subunit, PRKAR1B.Pathological accumulation of intermediate filaments can be observed in neurodegenerative disorders, such as Alzheimer's disease, frontotemporal dementia and Parkinson's disease, and is also characteristic of neuronal intermediate filament inclusion disease. Intermediate filaments type IV include three neurofilament proteins (light, medium and heavy molecular weight neurofilament subunits) and alpha-internexin. The phosphorylation of intermediate filament proteins contributes to axonal growth, and is regulated by protein kinase A. Here we describe a family with a novel late-onset neurodegenerative disorder presenting with dementia and/or parkinsonism in 12 affected individuals. The disorder is characterized by a unique neuropathological phenotype displaying abundant neuronal inclusions by haematoxylin and eosin staining throughout the brain with immunoreactivity for intermediate filaments. Combining linkage analysis, exome sequencing and proteomics analysis, we identified a heterozygous c.149T > G (p.Leu50Arg) missense mutation in the gene encoding the protein kinase A type I-beta regulatory subunit (PRKAR1B). The pathogenicity of the mutation is supported by segregation in the family, absence in variant databases, and the specific accumulation of PRKAR1B in the inclusions in our cases associated with a specific biochemical pattern of PRKAR1B. Screening of PRKAR1B in 138 patients with Parkinson's disease and 56 patients with frontotemporal dementia did not identify additional novel pathogenic mutations. Our findings link a pathogenic PRKAR1B mutation to a novel hereditary neurodegenerative disorder and suggest an altered protein kinase A function through a reduced binding of the regulatory subunit to the A-kinase anchoring protein and the catalytic subunit of protein kinase A, which might result in subcellular dislocalization of the catalytic subunit and hyperphosphorylation of intermediate filaments.
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- 2014
10. How to understand it: Neuropsychological testing
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Zucchella, C, Federico, A, Martini, A, Tinazzi, M, Bartolo, M, and Tamburin, S
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BF - Abstract
Neuropsychological testing is a key diagnostic tool for assessing people with dementia and mild cognitive impairment, but can also help in other neurological conditions such as Parkinson’s disease, stroke, multiple sclerosis, traumatic brain injury and epilepsy. While cognitive screening tests offer gross information, detailed neuropsychological evaluation can provide data on different cognitive domains (visuospatial function, memory, attention, executive function, language and praxis) as well as neuropsychiatric and behavioural features. We should regard neuropsychological testing as an extension of the neurological examination applied to higher order cortical function, since each cognitive domain has an anatomical substrate. Ideally, neurologists should discuss the indications and results of neuropsychological assessment with a clinical neuropsychologist. This paper summarises the rationale, indications, main features, most common tests and pitfalls in neuropsychological evaluation.
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- 2018
11. Alterazioni della connettività funzionale nel tremore essenziale (ET)
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Favaro, Giovanna, Boscolo Galazzo, I, Mansueto, G, Menegaz, G, Tinazzi, M, and Pizzini, Fb
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Neuroradiologia - Published
- 2018
12. Pain processing in functional and idiopathic dystonia: An exploratory study
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Morgante, F, Matinella, A, Andrenelli, E, Ricciardi, L, Allegra, C, Terranova, C, Girlanda, P, and Tinazzi, M
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Adult ,Male ,Pain Threshold ,cervical dystonia ,emotions ,functional movement disorders ,pain ,psychogenic dystonia ,Pain ,Middle Aged ,Severity of Illness Index ,Statistics, Nonparametric ,nervous system diseases ,Dystonia ,Young Adult ,Touch ,Case-Control Studies ,Physical Stimulation ,otorhinolaryngologic diseases ,Humans ,Female ,Pain Measurement - Abstract
BACKGROUND: Pain is often experienced by patients with functional dystonia and idiopathic cervical dystonia and is likely to be determined by different neural mechanisms. OBJECTIVE: In this exploratory study, we tested the sensory-discriminative and cognitive-emotional component of pain in patients with functional and idiopathic dystonia. METHODS: Ten patients with idiopathic cervical dystonia, 12 patients with functional dystonia, and 16 age- and sex-matched healthy controls underwent psychophysical testing of tactile and pain thresholds and pain tolerance. We delivered electrical pulses of increasing intensity to the index finger of each hand and the halluces of each foot. Pain threshold and pain tolerance were respectively defined as the (1) intensity at which sensation changed from unpainful to faintly painful and (2) intensity at which painful sensation was intolerable. RESULTS: No differences were found between the three groups for tactile and pain thresholds assessed in hands and feet. Pain tolerance was significantly increased in all body regions only in functional dystonia. Patients with continuous functional dystonia had higher pain tolerance compared to subjects with paroxysmal functional dystonia and idiopathic cervical dystonia. There was no correlation between pain tolerance and pain scores, depression, anxiety, disease duration, and motor disability in both groups. CONCLUSIONS: Patients with functional dystonia have a dissociation between the sensory-discriminative and cognitive-emotional components of pain, as revealed by normal pain thresholds and increased pain tolerance. Abnormal connectivity between the motor and limbic systems might account for abnormal pain processing in functional dystonia. © 2018 International Parkinson and Movement Disorder Society.
- Published
- 2017
13. Relationship between pain and motor and non-motor symptoms in Parkinson's disease
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Defazio, G, Antonini, A, Tinazzi, M, Gigante, A F, Pietracupa, S, Pellicciari, R, Bloise, M, Bacchin, R, Marcante, A, Fabbrini, G, Berardelli, A, and Domenicucci, Maurizio
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Parkinson's disease ,Disease ,motor symptoms ,non-motor symptoms ,pain ,Logistic regression ,03 medical and health sciences ,Cognition ,Sex Factors ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Neurology ,Neurology (clinical) ,Fatigue ,Aged ,Aged, 80 and over ,Movement Disorders ,Depression ,Mood Disorders ,business.industry ,Chronic pain ,Parkinson Disease ,Odds ratio ,Middle Aged ,medicine.disease ,030104 developmental biology ,Mood ,Italy ,Physical therapy ,Non motor ,Female ,Chronic Pain ,business ,030217 neurology & neurosurgery - Abstract
Background and purpose Although female gender, depressive symptoms and medical conditions predisposing to pain are more common in patients with Parkinson's disease (PD) with pain, no study has yet explored the relationship between pain and other non-motor symptoms (NMS). Methods A total of 321 consecutive patients with PD [190 men/131 women aged 68.3 (SD 9.2) years] attending four Italian movement disorder clinics were studied. Demographic/clinical data were obtained by a standardized interview and the NMS scale. The association of pain with motor and NMS was assessed by multivariable logistic regression models. Results At the time of the study, 180 patients with PD (56%) reported chronic pain that, in most cases, was described as being muscular or arthralgic pain. Pain preceded the onset of motor signs in 36/180 patients. In the main-effect model, factors independently associated with pain were female sex [odds ratio (OR), 2.1; P = 0.01], medical conditions predisposing to pain (OR, 2.9; P < 0.001), Hoehn–Yahr staging (OR, 1.9; P = 0.04), motor complications (OR, 4.7; P = 0.04) and NMS belonging to the sleep/fatigue (OR, 1.6; P = 0.04) and mood/cognition (OR, 1.6; P = 0.03) domains. Most explanatory variables in the multivariable analysis were similarly distributed in patients in whom pain may have been related to PD or to a cause other than PD. Conclusions We confirm that pain in PD is more frequent in women and in subjects with medical conditions predisposing to painful symptoms. Moreover, this strengthens the association between pain and motor severity measures and NMS domains, particularly sleep and mood disturbances.
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- 2017
14. Clinical variables associated with treatment changes in Parkinson’s disease: results from the longitudinal phase of the REASON study
- Author
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Abbruzzese, Giovanni, Barone, Paolo, Ceravolo, Roberto, Fabbrini, Giovanni, Lessi, Patrizia, Ori, Alessandra, Simoni, Lucia, Tinazzi, Michele, Antonini, Angelo, Melone, MAB, Schettino, C, Capaldo, G, Iemolo, F, Sanzaro, E, Ceravolo, MG, Capecci, M, Andrenelli, E, Pontieri, FE, Pellicano, C, Benincasa, D, Fabbrini, G, Pietracupa, S, Latorre, A, Tedeschi, G, Tessitore, A, Giordano, A, Bonuccelli, U, Frosini, D, Vanelli, F, Comi, G, Volonté, MA, Spagnolo, F, Scaglioni, A, Abrignani, G, Abbruzzese, G, Avanzino, L, Tamburini, T, Antonini, A, Facchini, S, Biundo, R, Altavista, MC, Roberti, C, Avarello, T, Bono, G, Riboldazzi, G, Leva, S, Del Sette, M, Carabelli, E, Traverso, E, Michelucci, R, Nassetti, S, Pasini, E, Padovani, A, Cottini, E, Bigni, B, Ruggieri, S, Modugno, N, Fischetti, M, Stefani, A, Pierantozzi, M, Stampanoni Bassi, M, Tinazzi, M, Ottaviani, S, Ajena, D, Trianni, G, Caggiula, M, Valenti, G, My, F, Grioli, S, La Farina, I, Zambito Marsala, S, Marchini, C, Gioulis, M, Asteggiano, G, L’Episcopo, MR, Saracco, E, Barone, P, Picillo, M, Moccia, M, Onofrj, M, Thomas, A, Denaro, A, Marini, C, De Santis, F, Spagnoli, V, L’Erario, R, Passadore, P, Belgrado, E, Mucchiut, M, Priori, A, Cogiamanian, F, Marchet, A., Abbruzzese, Giovanni, Barone, Paolo, Ceravolo, Roberto, Fabbrini, Giovanni, Lessi, Patrizia, Ori, Alessandra, Simoni, Lucia, Tinazzi, Michele, Antonini, Angelo, Melone, Mab, Schettino, C, Capaldo, G, Iemolo, F, Sanzaro, E, Ceravolo, Mg, Capecci, M, Andrenelli, E, Pontieri, Fe, Pellicano, C, Benincasa, D, Fabbrini, G, Pietracupa, S, Latorre, A, Tedeschi, G, Tessitore, A, Giordano, A, Bonuccelli, U, Frosini, D, Vanelli, F, Comi, G, Volonté, Ma, Spagnolo, F, Scaglioni, A, Abrignani, G, Abbruzzese, G, Avanzino, L, Tamburini, T, Antonini, A, Facchini, S, Biundo, R, Altavista, Mc, Roberti, C, Avarello, T, Bono, G, Riboldazzi, G, Leva, S, Del Sette, M, Carabelli, E, Traverso, E, Michelucci, R, Nassetti, S, Pasini, E, Padovani, A, Cottini, E, Bigni, B, Ruggieri, S, Modugno, N, Fischetti, M, Stefani, A, Pierantozzi, M, Stampanoni Bassi, M, Tinazzi, M, Ottaviani, S, Ajena, D, Trianni, G, Caggiula, M, Valenti, G, My, F, Grioli, S, La Farina, I, Zambito Marsala, S, Marchini, C, Gioulis, M, Asteggiano, G, L’Episcopo, Mr, Saracco, E, Barone, P, Picillo, M, Moccia, M, Onofrj, M, Thomas, A, Denaro, A, Marini, C, De Santis, F, Spagnoli, V, L’Erario, R, Passadore, P, Belgrado, E, Mucchiut, M, Priori, A, Cogiamanian, F, and Marchet, A.
- Subjects
Male ,medicine.medical_specialty ,Clinical variables ,Neurology ,Parkinson's disease ,Motor symptoms ,Non-motor symptoms ,Parkinson’s disease ,Treatment persistence ,Aged ,Female ,Humans ,Longitudinal Studies ,Middle Aged ,Parkinson Disease ,Physician's Role ,Severity of Illness Index ,Treatment Outcome ,Neurology (clinical) ,Psychiatry and Mental Health ,2708 ,Longitudinal Studie ,Dermatology ,Disease ,Internal medicine ,motor symptoms,non-motor symptoms ,Parkinson’s disease,treatment persistence ,Severity of illness ,Medicine ,Neuroradiology ,business.industry ,musculoskeletal, neural, and ocular physiology ,General Medicine ,medicine.disease ,nervous system diseases ,cardiovascular system ,Physical therapy ,Neurosurgery ,business ,Human - Abstract
To assess over a period of 9 months in a sample of Italian Parkinson’s disease (PD) patients reasons leading the neurologist to modify dopaminergic treatment and patients’ causes of dissatisfaction with ongoing therapy. To evaluate the influence of disease severity on therapy persistence. A disease severity balanced sample of PD patients with stable anti-parkinsonian drugs (APD) treatment was enrolled and evaluated every 3 months. Patients requiring APD treatment modifications were discontinued from the study. The probability to modify APD treatment is greater for higher motor (UPDRS scores) and non-motor symptoms (NMSS score) severity. Both from neurologist’s and patient’s perspective, motor symptoms were the main determinants underlying APD treatment modifications. Non-motor symptoms were cause of dissatisfaction with ongoing APD treatment for 52 % of the patients, while only 36 % of the neurologists considered these as valid reasons for therapy change. REASON is the first study in PD patients that prospectively examined reasons driving APD treatment changes. Results show that the disease severity significantly increases the probability of APD treatment change. Patients attribute greater relevance than neurologists to non-motor symptoms as reason requiring treatment changes. This confirms that patient and neurologist perceptions only partially overlap.
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- 2015
15. Adherence to anti-Parkinson drug therapy in the 'REASON' sample of Italian patients with Parkinson's disease: the linguistic validation of the Italian version of the 'Morisky Medical Adherence Scale-8 items'
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Fabbrini, G, Abbruzzese, G, Barone, P, Antonini, A, Tinazzi, M, Castegnaro, G, Rizzoli, S, Morisky, De, Lessi, P, Abbruzzese G, Cr, Ceravolo, R, Melone, M, Schettino, C, Califano, F, Ceravolo, M, Capecci, M, Andrenelli, E, Iemolo, F, Spadaro, D, Carnemolla, A, Pontieri, F, Pellicano, C, Benincasa, D, Pietracupa, S, Latorre, A, Tedeschi, G, Tessitore, A, Giordano, A, Bonuccelli, U, Frosini, D, Vanelli, F, Comi, G, Volonté, M, Spagnolo, F, Scaglioni, A, Abrignani, G, Avanzino, L, Tamburini, T, Facchini, S, Biundo, R, Altavista, M, Roberti, C, Asteggiano, G, L'Episcopo, M, Saracco, E, Avarello, T, Bono, G, Riboldazzi, G, Leva, S, Del Sette, M, Carabelli, E, Traverso, E, Michelucci, R, Nassetti, S, Pasini, E, Padovani, A, Cottini, E, Bigni, B, Ruggieri, S, Modugno, N, Fischetti, M, Stefani, A, Pierantozzi, M, Stampanoni Bassi, M, Ottaviani, S, Ajena, D, Trianni, G, My, F, Caggiula, M, Valenti, G, Grioli, S, La Farina, I, Zambito Marsala, S, Marchini, C, Gioulis, M, Picillo, M, Moccia, M, Denaro, A, Sebastianelli, L, Onofrj, M, Thomas, A, Marini, C, De Santis, F, Spagnoli, V, L'Erario, R, Passadore, P, Belgrado, E, Mucchiut, M, Priori, A, Cogiamanian, F, Marchet, A, Ori, A, Pirondi, S, Roncari, B, Sala, S, Sgarbi, S, Simoni, L, Trevisan, F, Zanoli, L, Fabbrini, G, Abbruzzese, G, Antonini, A, Barone, P, Ceravolo, R, Tinazzi, M, Melone, Mariarosa Anna Beatrice, Schettino, C, Califano, F, Ceravolo, Mg, Capecci, M, Andrenelli, E, Iemolo, F, Spadaro, D, Carnemolla, A, Pontieri, Fe, Pellicano, C, Benincasa, D, Pietracupa, S, Latorre, A, Tedeschi, Gioacchino, Tessitore, Alessandro, Giordano, A, Bonuccelli, U, Frosini, D, Vanelli, F, Comi, G, Volonté, Ma, Spagnolo, F, Scaglioni, A, Abrignani, G, Avanzino, L, Tamburini, T, Facchini, S, Biundo, R, Altavista, Mc, Roberti, C, Asteggiano, G, L'Episcopo, Mr, Saracco, E, Avarello, T, Bono, G, Riboldazzi, G, Leva, S, Nullm, nullDel Sette, Carabelli, E, Traverso, E, Michelucci, R, Nassetti, S, Pasini, E, Padovani, A, Cottini, E, Bigni, B, Ruggieri, S, Modugno, N, Fischetti, M, Stefani, A, Pierantozzi, M, Nullm, nullStampanoni Bassi, Ottaviani, S, Ajena, D, Trianni, G, My, F, Caggiula, M, Valenti, G, Grioli, S, Nulli, nullLa Farina, Nulls, nullZambito Marsala, Marchini, C, Gioulis, M, Picillo, M, Moccia, M, Denaro, A, Sebastianelli, L, Onofrj, M, Thomas, A, Marini, C, Nullf, nullDe Santi, Spagnoli, V, L'Erario, R, Passadore, P, Belgrado, E, Mucchiut, M, Priori, A, Cogiamanian, F, Marchet, A, Lessi, P, Castegnaro, G, Ori, A, Pirondi, S, Rizzoli, S, Roncari, B, Sala, S, Sgarbi, S, Simoni, L, Trevisan, F, Zanoli, L., Fabbrini, G., Abbruzzese, G., Barone, P., Antonini, A., Tinazzi, M., Castegnaro, G., Rizzoli, S., Morisky, D. E., Lessi, P., Ceravolo, R., Melone, M. A., Schettino, C., Califano, F., Ceravolo, M. G., Capecci, M., Andrenelli, E., Iemolo, F., Spadaro, D., Carnemolla, A., Pontieri, F. E., Pellicano, C., Benincasa, D., Pietracupa, S., Latorre, A., Tedeschi, G., Tessitore, A., Giordano, A., Bonuccelli, U., Frosini, D., Vanelli, F., Comi, G., Volonte, M. A., Spagnolo, F., Scaglioni, A., Abrignani, G., Avanzino, L., Tamburini, T., Facchini, S., Biundo, R., Altavista, M. C., Roberti, C., Asteggiano, G., L'Episcopo, M. R., Saracco, E., Avarello, T., Bono, G., Riboldazzi, G., Leva, S., Del Sette, M., Carabelli, E., Traverso, E., Michelucci, R., Nassetti, S., Pasini, E., Padovani, A., Cottini, E., Bigni, B., Ruggieri, S., Modugno, N., Fischetti, M., Stefani, A., Pierantozzi, M., Stampanoni Bassi, M., Ottaviani, S., Ajena, D., Trianni, G., My, F., Caggiula, M., Valenti, G., Grioli, S., La Farina, I., Zambito Marsala, S., Marchini, C., Gioulis, M., Picillo, M., Moccia, M., Denaro, A., Sebastianelli, L., Onofrj, M., Thomas, A., Marini, C., De Santis, F., Spagnoli, V., L'Erario, R., Passadore, P., Belgrado, E., Mucchiut, M., Priori, A., Cogiamanian, F., Marchet, A., Ori, A., Pirondi, S., Roncari, B., Sala, S., Sgarbi, S., Simoni, L., Trevisan, F., Morisky, De, Comi, Giancarlo, and REASON study, Group
- Subjects
Predictive validity ,Male ,Translation ,Parkinson's disease ,Adherence ,Comprehension ,Validation ,Aged ,Antiparkinson Agents ,Female ,Humans ,Parkinson Disease ,Translations ,Medication Adherence ,Surveys and Questionnaires ,Neurology (clinical) ,Psychiatry and Mental Health ,2708 ,MEDLINE ,Dermatology ,Disease ,Linguistic validation ,Pharmacotherapy ,Quality of life ,Medicine ,business.industry ,General Medicine ,Parkinson’s disease ,medicine.disease ,Psychiatry and Mental health ,Antiparkinson Agent ,Settore MED/26 - Neurologia ,business ,Human ,Clinical psychology - Abstract
Information about patients' adherence to therapy represents a primary issue in Parkinson's disease (PD) management. To perform the linguistic validation of the Italian version of the self-rated 8-Item Morisky Medical Adherence Scale (MMAS-8) and to describe in a sample of Italian patients affected by PD the adherence to anti-Parkinson drug therapy and the association between adherence and some socio-demographic and clinical features. MMAS-8 was translated into Italian language by two independent Italian mother-tongue translators. The consensus version was then back-translated by an English mother-tongue translator. This translation process was followed by a consensus meeting between the authors of translation and investigators and then by two comprehension tests. The translated version of the MMAS-8 scale was then administered at the baseline visit of the "REASON" study (Italian Study on the Therapy Management in Parkinson's disease: Motor, Non-Motor, Adherence and Quality Of Life Factors) in a large sample of PD patients. The final version of the MMAS-8 was easily understood. Mean ± SD MMAS-8 score was 6.1 ± 1.2. There were no differences in adherence to therapy in relationship to disease severity, gender, educational level or decision to change therapy. The Italian version of MMAS-8, the key tool of the REASON study to assess the adherence to therapy, has shown to be understandable to patients with PD. Patients enrolled in the REASON study showed medium therapy adherence.
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- 2013
16. Reasons driving treatment modification in Parkinson's disease: Results from the cross-sectional phase of the REASON study
- Author
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Tinazzi, M, Abbruzzese, G, Antonini, A, Ceravolo, R, Fabbrini, G, Lessi, P, Barone, P, REASON Study Group:Abruzzese, G, Lido, V, Melone, M, Schettino, C, Califano, F, Ceravolo, M, Capecci, M, Andrenelli, E, Iemolo, F, Spadaro, D, Carnemolla, A, Pontieri, F, Pellicano, C, Benincasa, D, Pietracupa, S, Latorre, A, Tedeschi, G, Tessitore, A, Giordano, A, Bonuccelli, U, Frosini, D, Vanelli, F, Comi, G, Volonté, M, Spagnolo, F, Scaglioni, A, Abrignani, G, Avanzino, L, Tamburini, T, Facchini, S, Biundo, R, Altavista, M, Roberti, C, Asteggiano, G, L'Episcopo, M, Saracco, E, Avarello, T, Bono, G, Riboldazzi, G, Leva, S, Del, S, Carabelli, M, E, Traverso, E, Michelucci, R, Nassetti, S, Pasini, E, Padovani, A, Cottini, E, Bigni, B, Ruggieri, S, Modugno, N, Fischetti, M, Stefani, A, Pierantozzi, M, Bassi, M, Ottaviani, S, Ajena, D, Trianni, G, My, F, Caggiula, M, Valenti, G, Grioli, S, La Farina, I, Zambito Marsala, S, Marchini, C, Gioulis, M, Picillo, M, Moccia, M, Denaro, A, Sebastianelli, L, Onofrj, M, Thomas, A, Marini, C, De Santis, F, Spagnoli, V, L'Erario, R, Passadore, P, Belgrado, E, Mucchiut, M, Priori, A, Cogiamanian, F, Marchet, A, Tinazzi, M, Abbruzzese, G, Antonini, A, Ceravolo, R, Fabbrini, G, Lessi, P, Barone, P, Lido, V, Melone, M, Schettino, C, Califano, F, Ceravolo, Mg, Capecci, M, Andrenelli, E, Iemolo, F, Spadaro, D, Carnemolla, A, Pontieri, F, Pellicano, C, Benincasa, D, Pietracupa, S, Latorre, A, Tedeschi, G, Tessitore, A, Giordano, A, Bonuccelli, U, Frosini, D, Vanelli, F, Comi, G, Volonté, M, Spagnolo, F, Scaglioni, A, Abrignani, G, Avanzino, L, Tamburini, T, Facchini, S, Biundo, R, Altavista, M, Roberti, C, Asteggiano, G, L'Episcopo, M, Saracco, E, Avarello, T, Bono, G, Riboldazzi, G, Leva, S, Del, Sette, M, Carabelli, E, Traverso, E, Michelucci, R, Nassetti, S, Pasini, E, Padovani, A, Cottini, E, Bigni, B, Ruggieri, S, Modugno, N, Fischetti, M, Stefani, A, Pierantozzi, M, Bassi, M, Ottaviani, S, Ajena, D, Trianni, G, My, F, Caggiula, M, Valenti, G, Grioli, S, La, Farina, I, Zambito, Marsala, S, Marchini, C, Gioulis, M, Picillo, M, Moccia, M, Denaro, A, Sebastianelli, L, Onofrj, M, Thomas, A, Marini, C, De, Santi, F, Spagnoli, V, L'Erario, R, Passadore, P, Belgrado, E, Mucchiut, M, Priori, A, Cogiamanian, F, Marchet, A., Tinazzi, M., Abbruzzese, G., Antonini, A., Ceravolo, R., Fabbrini, G., Lessi, P., Barone, P., Melone, M. A. B., Schettino, C., Califano, F., Ceravolo, M. G., Capecci, M., Andrenelli, E., Iemolo, F., Spadaro, D., Carnemolla, A., Pontieri, F. E., Pellicano, C., Benincasa, D., Pietracupa, S., Latorre, A., Tedeschi, G., Tessitore, A., Giordano, A., Bonuccelli, U., Frosini, D., Vanelli, F., Comi, G., Volonte, M. A., Spagnolo, F., Scaglioni, A., Abrignani, G., Avanzino, L., Tamburini, T., Facchini, S., Biundo, R., Altavista, M. C., Roberti, C., Asteggiano, G., L'Episcopo, M. R., Saracco, E., Avarello, T., Bono, G., Riboldazzi, G., Leva, S., Del Sette, M., Carabelli, E., Traverso, E., Michelucci, R., Nassetti, S., Pasini, E., Padovani, A., Cottini, E., Bigni, B., Ruggieri, S., Modugno, N., Fischetti, M., Stefani, A., Pierantozzi, M., Stampanoni Bassi, M., Ottaviani, S., Ajena, D., Trianni, G., My, F., Caggiula, M., Valenti, G., Grioli, S., La Farina, I., Zambito Marsala, S., Marchini, C., Gioulis, M., Picillo, M., Moccia, M., Denaro, A., Sebastianelli, L., Onofrj, M., Thomas, A., Marini, C., De Santis, F., Spagnoli, V., L'Erario, R., Passadore, P., Belgrado, E., Mucchiut, M., Priori, A., Cogiamanian, F., Lessi, and Comi, Giancarlo
- Subjects
Male ,Pediatrics ,Parkinson's disease ,anti-Parkinson drugs ,motor symptoms ,non-motor symptoms ,Practice Patterns ,Socioeconomic Factor ,Motor symptoms ,Severity of Illness Index ,Antiparkinson Agents ,Cohort Studies ,Motor symptom ,Practice Patterns, Physicians' ,Stage (cooking) ,Anti-Parkinson drug ,Anti-Parkinson drugs ,Non-motor symptoms ,Aged ,Female ,Humans ,Middle Aged ,Parkinson Disease ,Patient Satisfaction ,Socioeconomic Factors ,Geriatrics and Gerontology ,Neurology (clinical) ,Neurology ,musculoskeletal, neural, and ocular physiology ,Antiparkinson Agent ,cardiovascular system ,Settore MED/26 - Neurologia ,Treatment modification ,Human ,medicine.medical_specialty ,Non-motor symptom ,Disease severity ,medicine ,In patient ,Physicians' ,business.industry ,Advanced stage ,medicine.disease ,nervous system diseases ,Physical therapy ,Treatment decision making ,Cohort Studie ,business - Abstract
OBJECTIVES: To assess the association between clinical and socio-demographic features and anti-Parkinson drug (APD) treatment modifications in patients with PD and to describe neurologist and patient opinions regarding the need for changes in APD therapy. METHODS: Subjects with PD with stable APD treatment over ≥3 months prior to baseline were enrolled and evaluated for socio-demographic data, disability, disease severity and neurologist and patient views on the need to modify APD treatment. RESULTS: 775 Patients were included, 51% with Hoehn and Yahr (HY) stage 1-2 (early PD) and 49% with HY stage 2.5-4 (advanced PD). Neurologists modified APD treatment in 255 patients, 97 (25%) early PD and 158 (41%; p < 0.0001) advanced PD. APD modification was strongly associated with a low educational level and UPDRS part IV score. The most common reasons behind the APD therapy changes among neurologists were presence/worsening of motor or non-motor symptoms (88% and 37% of subjects respectively). Out of 216 patients, 92% and 51% were willing to undergo APD changes to therapy because of the presence/worsening of motor or non-motor symptoms. CONCLUSIONS: Neurologist decision to change APD therapy and patients reasons for dissatisfaction with it can be prevalently attributed to the presence/worsening of motor symptoms and motor fluctuations in the advanced stages. Non-motor symptoms were considered more often by patients. The patient educational level played a key role in treatment decision.
- Published
- 2013
17. Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes
- Author
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Bonifati V., Rohe C. F., Breedveld G. J., Fabrizio E., De Mari M., Tassorelli C., Tavella A., Marconi R., Nicholl D. J., Chien H. F., Fincati E., Abbruzzese G., Marini P., De Gaetano A., Horstink M. W., Maat Kievit J. A., Sampaio C., Antonini A., Stocchi F., Toni V., Guidi M., Dalla Libera A., Tinazzi M., De Pandis F., Fabbrini G., Goldwurm S., de Klein A., Barbosa E., Lopiano L., Martignoni E., Lamberti P., Vanacore N., Meco G., Oostra B.A., Italian Parkinson Genetics Network, MONTAGNA, PASQUALE, Bonifati V., Rohe C.F., Breedveld G.J., Fabrizio E., De Mari M., Tassorelli C., Tavella A., Marconi R., Nicholl D.J., Chien H.F., Fincati E., Abbruzzese G., Marini P., De Gaetano A., Horstink M.W., Maat-Kievit J.A., Sampaio C., Antonini A., Stocchi F., Montagna P., Toni V., Guidi M., Dalla Libera A., Tinazzi M., De Pandis F., Fabbrini G., Goldwurm S., de Klein A., Barbosa E., Lopiano L., Martignoni E., Lamberti P., Vanacore N., Meco G., Oostra BA., Italian Parkinson Genetics Network., and Clinical Genetics
- Subjects
Adult ,Male ,DNA, Complementary ,Adolescent ,Genotype ,Parkinson's disease ,assessment ,DNA Mutational Analysis ,Mutation, Missense ,Biology ,Early-onset parkinsonism ,medicine.disease_cause ,Genotype-phenotype distinction ,Cognitive neurosciences [UMCN 3.2] ,Gene Frequency ,PINK1 gene mutations ,medicine ,Missense mutation ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Allele ,Age of Onset ,Child ,Allele frequency ,Genetics ,Mutation ,Parkinson'disease ,Genome ,Polymorphism, Genetic ,Sequence Homology, Amino Acid ,Parkinsonism ,Parkinson Disease ,Middle Aged ,medicine.disease ,Phenotype ,Italy ,Female ,Neurology (clinical) ,Age of onset ,Protein Kinases - Abstract
Item does not contain fulltext OBJECTIVE: To assess the prevalence, nature, and associated phenotypes of PINK1 gene mutations in a large series of patients with early-onset (
- Published
- 2005
18. Functional connectivity networks in asymptomatic and symptomatic DYT1 carriers
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Premi, E, Diano, Matteo, Gazzina, S, Cauda, Franco, Gualeni, V, Tinazzi, M, Fiorio, M, Liberini, P, Lazzarini, C, Archetti, S, Biasiotto, G, Turla, M, Bertasi, V, Cotelli, M, Gasparotti, R, Padovani, A, and Borroni, B.
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Adult ,Cerebral Cortex ,Male ,Heterozygote ,resting-state functional connectivity ,Dystonia Musculorum Deformans ,DYT1 ,Middle Aged ,Magnetic Resonance Imaging ,Connectome ,Humans ,Female ,dystonia ,dual regression ,Molecular Chaperones - Abstract
DYT1 mutation is characterized by focal to generalized dystonia and incomplete penetrance. To explore the complex perturbations in the different neural networks and the mutual interactions among them, we studied symptomatic and asymptomatic DTY1 mutation carriers by resting-state functional MRI.A total of 7 symptomatic DYT1, 10 asymptomatic DYT1, and 26 healthy controls were considered. Resting-state functional MRI (Oxford Centre for Functional MRI of the Brain) [FMRIB] Software Library) (FSL) MELODIC, dual regression, (as a toolbox of FSL, with Nets is referred to "networks") (FSLNets) (http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FSLNets) was performed on 9 resting-state neural networks.DYT1 mutation signature (symptomatic DYT1 and asymptomatic DYT1) was characterized by increased connectivity in the dorsal attention network and in the left fronto-parietal network. Functional correlates of symptomatic DYT1 patients (symptomatic DYT1 vs healthy controls) showed increased connectivity in the sensorimotor network.This study argues that DYT1 dystonia is a network disorder, with crucial nodes in sensory-motor integration of posterior parietal structures. A better characterization of cortical networks involved in dystonia is crucial for possible neurophysiological therapeutic interventions. © 2016 International Parkinson and Movement Disorder Society.
- Published
- 2016
19. Rehabilitation procedures in the management of gait disorders in the elderly
- Author
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Gandolfi, M., Dimitrova, E., Nicolli, F., Modenese, A., Serina, A., Waldner, A., Tinazzi, M., Giovanna Squintani, Smania, N., and Geroin, C.
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sarcopenia ,posture ,gait ,aging ,nervous system diseases ,postural balance - Abstract
Gait disorders are common and very disabling in elderly people, leading to an increase of risk of falling and reductions in quality of life. So far, many clinical classifications of gait disorders in the elderly population have been proposed. Here we suggest a novel categorization of gait disorders in elderly people, which takes into account the several resources required during gait. The biomechanical constraints, movement and sensory strategies, orientation in space, control of dynamics and cognitive processing are essential to perform safely gait. Moreover, the strictly connection between gait and balance has been discussed. According to this perspective, a literature search was performed including studies investigating the rehabilitation procedures in the management of balance and gait disorders in elderly people. Training aimed at improving muscle strength and flexibility, movement strategies, sensorimotor integration and sensory reweighting processes, balance in static and dynamic conditions and cognitive strategies have been proposed as possible therapeutic approaches in elderly people affected by gait disorders. Moreover, the role of new technological devices in improving balance and gait control has been also described. A multidisciplinary and interdisciplinary approach is fundamental for the management of gait disorders in elderly people. Rehabilitation procedures should take into consideration all the potential constraints involved in gait disorders in order to select the most appropriate intervention.
- Published
- 2015
20. Validation of the Italian version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale
- Author
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Antonini, A, Abbruzzese, G, Ferini Strambi, L, Tilley, B, Huang, J, Stebbins, Gt, Goetz, Cg, Barone, P, MDS UPDRS Italian Validation Study Group, Bandettini di Poggio, M, Fabbrini, G, Di Stasio, F, Tinazzi, M, Bovi, T, Ramat, S, Meoni, S, Pezzoli, G, Canesi, M, Martinelli, P, Maria Scaglione CL, Rossi, A, Tambasco, N, Santangelo, G, Picillo, M, Morgante, Letterio, Morgante, Francesca, Quatrale, R, Sensi, M, Pilleri, M, Biundo, R, Nordera, G, Caria, A, Pacchetti, C, Zangaglia, R, Lopiano, L, Zibetti, M, Zappia, M, Nicoletti, A, Quattrone, A, Salsone, M, Cossu, G, Murgia, D, Albanese, A, Del Sorbo, F., Antonini, A, Abbruzzese, G, Ferini Strambi, L, Tilley, B, Huang, J, Stebbins, Gt, Goetz, Cg, Barone, P, MDS UPDRS Italian Validation Study, Group, Bandettini di Poggio, M, Fabbrini, G, Di Stasio, F, Tinazzi, M, Bovi, T, Ramat, S, Meoni, S, Pezzoli, G, Canesi, M, Martinelli, P, Maria Scaglione, Cl, Rossi, A, Tambasco, N, Santangelo, Gabriella, Picillo, M, Morgante, L, Morgante, F, Quatrale, R, Sensi, M, Pilleri, M, Biundo, R, Nordera, G, Caria, A, Pacchetti, C, Zangaglia, R, Lopiano, L, Zibetti, M, Zappia, M, Nicoletti, A, Quattrone, A, Salsone, M, Cossu, G, Murgia, D, Albanese, A, and Del Sorbo, F.
- Subjects
Male ,Unified Parkinson's Disease Rating Scale ,Mds updrs ,Parkinson's disease ,Unified Parkinson’s Disease Rating Scale ,Unified Parkinson's disease rating scale ,Dermatology ,Neuropsychological Tests ,Factor structure ,Severity of Illness Index ,MDS-UPDRS ,rating scale ,rating scales ,Disability Evaluation ,Rating scale ,Medical ,Humans ,Translations ,Societies, Medical ,Neurologic Examination ,Protocol (science) ,Movement Disorders ,Movement (music) ,Reproducibility of Results ,Parkinson Disease ,General Medicine ,Statistical ,Linguistics ,Focus (linguistics) ,Settore MED/26 - NEUROLOGIA ,Psychiatry and Mental health ,Italy ,Index (publishing) ,Female ,Neurology (clinical) ,Societies ,Factor Analysis, Statistical ,Psychology ,Factor Analysis ,Social psychology - Abstract
The Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) has been available in English since 2008. As part of this process, the MDS-UPDRS organizing team developed guidelines for development of official non- English translations. We present here the formal process for completing officially approved non-English versions of the MDS-UPDRS and specifically focus on the first of these versions in Italian. The MDS-UPDRS was translated into Italian and tested in 377 native-Italian speaking PD patients. Confirmatory and exploratory factor analyses determined whether the factor structure for the English- language MDS-UPDRS could be confirmed in data col- lected using the Italian translation. To be designated an 'Official MDS translation,' the Comparative Fit Index (CFI) had to be C0.90 relative to the English-language version. For all four parts of the Italian MDS-UPDRS, the CFI, in comparison with the English-language data, was C0.94. Exploratory factor analyses revealed some differ- ences between the two datasets, however these differences were considered to be within an acceptable range. The Italian version of the MDS-UPDRS reaches the criterion to be designated as an Official Translation and is now avail- able for use. This protocol will serve as outline for further validation of this in multiple languages.
- Published
- 2013
21. Trigeminal laser-evoked potentials:a neurophysiological tool to detect post-surgical outcome in trigeminovascular contact neuralgia
- Author
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Squintani, G., Turri, M., Donato, F., Tinazzi, M., Masotto, B., Tramontano, V., Talacchi, A., Sala, F., Moretto, G., and Valeriani, Massimiliano
- Subjects
nociceptive system ,Adult ,Male ,trigeminal laser-evoked potentials ,trigeminal neuralgia ,patients ,surgery ,Middle Aged ,Trigeminal Neuralgia ,Laser-Evoked Potentials ,Treatment Outcome ,Humans ,Female ,Trigeminal Nerve ,Aged ,Pain Measurement - Abstract
The aim of this study was to explore the nociceptive system of patients affected by trigeminal neuralgia (TN) secondary to documented vascular contact who underwent microvascular decompression. For that purpose, we used the classical trigeminal reflexes and the trigeminal laser-evoked potentials (tLEPs) before and after surgery, in order to verify any possible change after decompression and determine if there was any correlation between the neurophysiological parameters and the clinical outcome.Eleven patients affected by TN caused by trigeminovascular contact and 10 age-matched controls underwent conventional trigeminal reflexes (bilateral Blink Reflex/BR and Masseter Inhibitory Reflex stimulating infraorbital and mental nerves/MIR V2 and V3) and tLEPs. Patients repeated neurophysiological tests one week after surgery.Short-latency BR and MIR were normal in all patients before surgery and there was no statistical difference before and after surgery. Conversely, in patients before surgery, tLEPs' amplitudes were significantly lower in the affected than in the healthy side (p = 0.017 for V2 and 0.037 for V3 branches). After surgery, on the affected side, tLEP amplitude increased and the pre/post-operative difference was significant (p = 0.017 for V2 and 0.028 for V3 divisions). Nine patients referred satisfactory pain relief and the favourable clinical outcome correlated with the neurophysiological recovery.This study demonstrates that TN caused by trigeminovascular compression may be related to Aδ fibres impairment, and tLEPs are more sensitive than conventional trigeminal reflexes to reveal small fibre dysfunction and to monitor the post-surgical outcome in these patients.
- Published
- 2015
22. Prevalence and associated features of self-reported freezing of gait in Parkinson disease: The DEEP FOG study
- Author
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Amboni, M, Stocchi, F, Abbruzzese, G, Morgante, L, Onogrj, M, Ruggieri, S, Tinazzi, M, Zappia, Mario, Attar, M, Colombo, D, Simoni, L, Ori, A, Barone, P, Antonini, A, and DEEP Study Group
- Subjects
Male ,Parkinson's disease ,genetic structures ,Disease ,Severity of Illness Index ,Antiparkinson Agents ,Levodopa ,Quality of life ,Risk Factors ,Freezing of gait ,Wearing-off ,Aged ,Aged, 80 and over ,Female ,Gait Disorders, Neurologic ,Humans ,Middle Aged ,Parkinson Disease ,Prevalence ,Quality of Life ,Self Report ,Surveys and Questionnaires ,Freezing Reaction, Cataleptic ,Gait ,Geriatrics and Gerontology ,Neurology (clinical) ,Neurology ,Medicine (all) ,80 and over ,education.field_of_study ,freezing of gait ,wearing-off ,Freezing Reaction ,medicine.drug ,medicine.medical_specialty ,Population ,Physical medicine and rehabilitation ,Rating scale ,medicine ,Neurologic ,Effects of sleep deprivation on cognitive performance ,Gait Disorders ,education ,business.industry ,medicine.disease ,business ,Cataleptic - Abstract
Freezing of Gait (FOG) is a common and disabling symptom in patients with Parkinson disease (PD). The relationship between FOG and dopaminergic medication is complex. The aim of the present study was to estimate the prevalence of self-reported FOG, its associated clinical features, and its relationship with wearing-off in a wide PD population. This is an observational multicenter study of 634 consecutive non-demented PD patients. Patients were identified either as freezers or non-freezers based on item-3 of the Freezing of Gait-Questionnaire. FOG was then classified as on, off and onoff freezing based on its relationship with wearing-off. Patients were assessed with Unified Parkinson's Disease Rating Scale, Hoehn and Yahr scale, 8-item Parkinson's disease Questionnaire, Mini-Mental State Examination. Data from 593 patients were analyzed, 325 (54.3%) were freezers of whom 200 (61.6%) experienced FOG only during off state (off-freezers), 6 (1.8%) only during on state and 119 (36.6%) either in on and off states or independently of dopaminergic response-related symptoms (onoff-freezers). Overall, freezers vs non-freezers had longer disease duration, more advanced disease and greater disability. Moreover, freezers more frequently reported wearing-off and experienced worse quality of life. Onoff-freezers vs off-freezers were older, more severely disabled, less likely to experience wearing-off, treated with lower levodopa equivalent daily dose and with poorer cognitive performance. Self-reported FOG is mainly recognizable in advanced PD and is associated with more disability and worse quality of life. Onoff-FOG may represent the result of under-treatment or rather interpretable as a distinct clinical entity.
- Published
- 2015
23. Sensory-motor integration in focal dystonia
- Author
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Avanzino, L., Tinazzi, M., Ionta, S., and Fiorio, M.
- Subjects
Cerebral Cortex/pathology ,Cerebral Cortex/physiopathology ,Dystonic Disorders/pathology ,Dystonic Disorders/physiopathology ,Humans ,Movement/physiology ,Neural Pathways/physiopathology ,Sensation/physiology - Abstract
Traditional definitions of focal dystonia point to its motor component, mainly affecting planning and execution of voluntary movements. However, focal dystonia is tightly linked also to sensory dysfunction. Accurate motor control requires an optimal processing of afferent inputs from different sensory systems, in particular visual and somatosensory (e.g., touch and proprioception). Several experimental studies indicate that sensory-motor integration - the process through which sensory information is used to plan, execute, and monitor movements - is impaired in focal dystonia. The neural degenerations associated with these alterations affect not only the basal ganglia-thalamic-frontal cortex loop, but also the parietal cortex and cerebellum. The present review outlines the experimental studies describing impaired sensory-motor integration in focal dystonia, establishes their relationship with changes in specific neural mechanisms, and provides new insight towards the implementation of novel intervention protocols. Based on the reviewed state-of-the-art evidence, the theoretical framework summarized in the present article will not only result in a better understanding of the pathophysiology of dystonia, but it will also lead to the development of new rehabilitation strategies.
- Published
- 2015
24. GIGYF2 mutations are not a frequent cause of familial Parkinson's disease
- Author
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Di Fonzo A., Fabrizio E., Thomas A., Fincati E., Marconi R., Tinazzi M., Breedveld G. J., Simons E. J., Chien H. F., Ferreira J. J., Horstink M. W., Abbruzzese G., Borroni B., Cossu G., Dalla Libera A., Fabbrini G., Guidi M., De Mari M., Lopiano L., Martignoni E., Marini P., Onofrj M., Padovani A., Stocchi F., Toni V., Sampaio C., Barbosa E. R., Meco G., Italian Parkinson Genetics Network, Oostra B. A, Bonifati V., MONTAGNA, PASQUALE, Erasmus MC other, Clinical Genetics, Di Fonzo A., Fabrizio E., Thomas A., Fincati E., Marconi R., Tinazzi M., Breedveld G.J., Simons E.J., Chien H.F., Ferreira J.J., Horstink M.W., Abbruzzese G., Borroni B., Cossu G., Dalla Libera A., Fabbrini G., Guidi M., De Mari M., Lopiano L., Martignoni E., Marini P., Onofrj M., Padovani A., Stocchi F., Toni V., Sampaio C., Barbosa E.R., Meco G., Italian Parkinson Genetics Network, Montagna P., Oostra B.A, and Bonifati V.
- Subjects
Proband ,Adult ,Parkinson's disease ,PARK11 ,Locus (genetics) ,Disease ,Biology ,Genetics ,GIGYF2 ,Mutation ,medicine ,Coding region ,Humans ,parkinson disease ,Gene ,Aged ,Parkinson Disease ,Middle Aged ,medicine.disease ,Pedigree ,Neurology ,Carrier protein ,Neurology (clinical) ,Geriatrics and Gerontology ,Carrier Proteins ,genetics ,gigyf2 ,mutation ,park11 ,parkinson's disease - Abstract
Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. (C) 2009 Elsevier Ltd. All rights reserved.
- Published
- 2009
25. Pisa Syndrome in Parkinson's disease: demographic and clinical correlations in a multicenter italian study
- Author
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Geroin, C, Tinazzi, M, Vitale, C, Bombieri, F, Juergenson, I, Smania, N, Schena, F, Ottaviani, S, Bisoffi, G, Mirandola, R, Canesi, M, Pezzoli, G, Ceravolo, R, Mazzucchi, S, Rossi, S, Ulivelli, M, Thomas, A, Di Giacomo, R, Fabbrini, G, Sarchioto, M, Bentivoglio, A, Bove, F, Tamma, F, Lucchese, V, Cossu, G, Di Stefano, F, Pisani, A, Amadeo, G, Modugno, N, Lena, F, Zappia, Mario, Nicoletti, Alessandra, Leocani, L, Volontè, A, Spagnolo, F, Dallocchio, C, Sciarretta, M, Altavilla, T, Abbruzzese, G, Cordano, C, Pacchetti, C, Pozzi, N, Marconi, R, Gallerini, S, Allocca, R, Defazio, G, Morgante, F, Ricciardi, L, Cannas, A, Solla, P, Fasano, A, and Barone, P.
- Published
- 2014
26. Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease
- Author
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Marongiu, R., Ghezzi, D., Ialongo, T., Soleti, F., Elia, A., Cavone, S., Albanese, A., Altavista, M. C., Barone, P., Brusa, L., Cortelli, P., Petrozzi, L., Scaglione, C., Stanzione, P., Tinazzi, M., Zeviani, M., Dallapiccola, B., Bentivoglio, A. R., Valente, E. M., Garavaglia, B., Conca, E., Fasano, A., Marelli, C., Martinelli, P., Nordera, G., Pellecchia, M. T., Marongiu R., Ghezzi D., Ialongo T., Soleti F., Elia A., Cavone S., Albanese A., Altavista M.C., Barone P., Brusa L., Cortelli P., Petrozzi L., Scaglione C., Stanzione P., Tinazzi M., Zeviani M., Dallapiccola B., Bentivoglio A.R., Valente E.M., Garavaglia B., and and the Italian PD Study Group.
- Subjects
Proband ,Male ,Parkinson's disease ,Late onset ,Protein Serine-Threonine Kinases ,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ,Heterozygote Detection ,Gene Frequency ,Medicine ,Humans ,LRRK2 ,Dardarin ,mutation screening ,Italy ,Mutation frequency ,Family history ,Allele frequency ,Genetics ,business.industry ,Genetic Carrier Screening ,Haplotype ,Parkinson Disease ,Protein-Serine-Threonine Kinases ,Settore MED/26 - NEUROLOGIA ,Mutation screening ,Amino Acid Substitution ,Female ,Phenotype ,Mutation ,Neurology ,Mutation (genetic algorithm) ,Neurology (clinical) ,business - Abstract
To evaluate the frequency of the LRRK2 G2019S mutation in Italy, we tested 1,072 probands with Parkinson's disease (PD; 822 sporadic and 250 familial): 20 patients (1.9%) carried the G2019S mutation, 11 patients (1.3%) were sporadic, and 9 (4.3%) had a positive family history. Considering only probands with autosomal dominant inheritance, the G2019S frequency raises to 5.2%. All presented a typical phenotype with variable onset and shared the common ancestral haplotype. Mutation frequency raised from 1.2% in early onset PD to 4.0% in late onset PD.
- Published
- 2006
27. Validation of the Italian version of Parkinson's disease-cognitive rating scale (PD-CRS)
- Author
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Santangelo, G., Barone, P., Abbruzzese, G., Ferini Strambi, L., Antonini, A, Bandettini, M., Fabbrini, G., Di Stasio, F., Tinazzi, M., Bovi, T., Ramat, S., Meoni, S., Pezzoli, G., Siri, C., Canesi, M., Martinelli, P., Scaglione, C. L., Rossi, A., Tambasco, N., Picillo, M., Morgante, Letterio, Morgante, Francesca, Quatrale, R., Sensi, M. C., Pilleri, M., Biundo, R., Nordera, G., Caria, A., Pacchetti, C., Zangaglia, R., Lopiano, L., Zibetti, M., Morgante, L., Morgante, F., Zappia, M., Nicoletti, A., Quattrone, A., Salsone, M., Cossu, G., Murgia, D., Albanese, A., Del Sorbo, F., Santangelo, Gabriella, Barone, Paolo, Abbruzzese, Giovanni, Ferini-strambi, Luigi, and Antonini, Angelo
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,Neurology ,Dermatology ,Audiology ,Neuropsychological Tests ,Cognition Disorder ,Cognitive dysfunction ,Rating scale ,medicine ,Dementia ,Humans ,Cognitive dysfunctions ,Mild cognitive impairment ,Parkinson's Disease Cognitive Rating Scale (PD-CRS) ,Aged ,Cognition Disorders ,Female ,Italy ,Middle Aged ,Parkinson Disease ,Neurology (clinical) ,Psychiatry and Mental Health ,2708 ,Psychiatry ,Working memory ,Cognition ,General Medicine ,medicine.disease ,Confidence interval ,Psychiatry and Mental health ,Ceiling effect ,Neuropsychological Test ,Psychology ,Human - Abstract
Cognitive impairment (CI) is a frequent feature associated with both early and advanced stages of Parkinson's disease (PD). An evaluation of cognitive functions is relevant to identify those parkinsonians at risk of developing dementia. In the present study, the Italian version of Parkinson's Disease-Cognitive Rating Scale (PD-CRS) assessing fronto-subcortical and cortical cognitive functions in PD was validated in 387 parkinsonians and was used to test the empirical validity of the item 1.1 (cognitive impairment) of the Italian version of MDS-UPDRS as screening tool for CI in PD. PD-CRS was free from floor and ceiling effect. The mean PD-CRS score was 76.1 (mean cortical score, 24.5 ± 4.6; mean subcortical score, 51.5 ± 17.5). The internal consistency was satisfactory (α = 0.89); corrected item-total correlation was 0.570 (naming) to 0.696 (working memory). The correlation between PD-CRS and part I-IV of MDS-UPDRS was weak. The low agreement between classification of PD sample into patients with mild cognitive impairment (PD-MCI), dementia (PD-D) and normal cognition (PD-NC) according to scores of item 1.1 and classification according to cutoff scores of PD-CRS for PD-MCI, PD-D and PD-NC indicated a poor empirical validity of item 1.1 of MDS-UPDRS as cognitive screening tool for CI in PD (Π= 0.114; weighted Π= 0.17; SE of Π= 0.038; 95 % confidence interval from 0.040 to 0.1895). The Italian version of PD-CRS is an easy, consistent and valid tool for assessment of the cognitive cortical and subcortical impairments in PD. © 2013 Springer-Verlag.
- Published
- 2013
28. Disease progression and response to levodopa in patients with schizophrenia and parkinsonism are related to imaging of the dopamine trasnporter: a 2-year follow-up study
- Author
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Morgante, F, Matinella, A, Bovi, T, Cannas, A, Solla, P, Nicoletti, Alessandra, Zappia, Mario, Luca, A, Di Stefano, A, Morgante, L, Pacchetti, C, Minafra, B, Sciarretta, M, Dallocchio, C, Rossi, S, Ulivelli, M, Ceravolo, R, Frosini, D, Cipriani, A, Barbui, C, and Tinazzi, M.
- Published
- 2013
29. Pisa syndrome in parkinson’s disease: demographic and clinical correlations in a multi center italian study
- Author
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Tinazzi, M, Juergenson, I, Bombieri, F, Schena, F, Ottaviani, S, Bovi, T, Bisoffi, G, Uniati, C, Canesi, M, Pezzoli, G, Ceravolo, R, Frosini, D, Rossi, S, Ulivelli, M, Thomas, A, Di Giacomo, R, Fabbrini, G, Sachioto, M, Bentivoglio, A, Bove, F, Tamma, F, Lucchese, V, Cossu, G, Di Stefano, F, Pisani, A, Amadeo, G, Modugmo, N, Lena, F, Zappia, Mario, Raciti, L, Nicoletti, Alessandra, Volontè, M, Spagnolo, F, Dallocchio, C, Sciarretta, M, Altavilla, T, Abbruzzese, G, Cordano, C, Pacchetti, C, Pozzi, N, Marconi, R, Gallerini, S, Mignarri, A, Allocca, R, Defazio, G, Morgante, F, Ricciardi, L, Cannas, A, Solla, P, Vitale, C, Fasano, A, and Barone, P.
- Published
- 2013
30. [(123I)]FP-CIT single photon emission computed tomography findings in drug-induced Parkinsonism (vol 113, pg 41, 2009)
- Author
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Tinazzi, M, Cipriani, A, Matinella, A, Cannas, A, Solla, P, Nicoletti, A, Zappia, M, Morgante, L, Morgantee, F, Pacchetti, C, Sciarretta, M, Dallocchio, C, Rossi, S, Malentacchi, M, Ceravolo, R, Frosini, D, Sestini, S, Bovi, T, and Barbui, C
- Published
- 2012
31. [¹²³I]FP-CIT single photon emission computed tomography findings in drug-induced Parkinsonism
- Author
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Tinazzi, M, Cipriani, A, Matinella, A, Cannas, A, Solla, P, Nicoletti, A, Zappia, M, Morgante, L, Morgante, F, Pacchetti, C, Sciarretta, M, Dallocchio, C, Rossi, S, Malentacchi, M, Ceravolo, R, Frosini, D, Sestini, S, Bovi, T, and Barbui, C
- Abstract
Drug-induced parkinsonism (DIP) in patients treated with antipsychotic drugs is considered a form of post-synaptic parkinsonism, caused by D2-receptor blockade. Recent studies, however, carried out on small and heterogeneous patient samples, have shown that DIP may be associated with [(123)I]FP-CIT single photon emission computed tomography (SPECT) abnormalities, which are markers of dopamine nigrostriatal terminal defect. In the present study, outpatients fulfilling the DSM-IV criteria for schizophrenia and treated with antipsychotics for at least 6 months, were enrolled in order to estimate the prevalence of DIP and, among patients with DIP, the prevalence of [(123)I]FP-CIT SPECT abnormalities. Socio-demographic and clinical variables associated with the presence of DIP and SPECT abnormalities were also assessed. DIP was diagnosed in 149 out of 448 patients with schizophrenia (33%). Age, use of long-acting antipsychotics and a positive family history of parkinsonism were the only demographic variables significantly associated with the development of DIP. Neuroimaging abnormalities were found in 41 of 97 patients who agreed to undergo [(123)I]FP-CIT SPECT (42%). Only age differentiated this group of patients from those with normal imaging. These preliminary findings suggest that D2-receptor blockade may coexist with a dopamine nigrostriatal terminal defect, as assessed by [(123)I]FP-CIT SPECT abnormalities, in a relevant proportion of DIP patients. Longitudinal studies should be designed with the aim of improving our understanding of the mechanisms of pre-synaptic abnormalities in DIP patients and identifying specific treatment strategies.
- Published
- 2012
32. ([23I]) FP-CIT single photon emission computed tomography findings in drug-induced parkinsonism
- Author
-
Tinazzi, M, Cipriani, A, Matinella, A, Cannas, A, Solla, P, Nicoletti, Alessandra, Zappia, Mario, Morgante, L, Morgante, F, Pachetti, C, Sciarretta, M, Dallocchio, C, Rossi, S, Malentacchi, M, Ceravolo, R, Frosini, D, Sestini, S, Bovi, T, Barbui, C, and Barbui, C.
- Published
- 2012
33. The relationship between cerebral vascular disease and parkinsonism: The VADO study
- Author
-
Antonini, A., Vitale, C., Barone, P., Cilia, R., Righini, A., Bonuccelli, U., Abbruzzese, G., Ramat, S., Petrone, A., Quatrale, R., Marconi, R., Ceravolo, R., Stefani, A., Lopiano, L., Zappia, M., Capus, L., Morgante, L., Tamma, F., Tinazzi, M., Colosimo, C., Guerra, U. P., Valzania, F., Fagioli, G., Distefano, A., Bagnato, A., Feggi, L., Anna, S., Maria Teresa Rosaria De Cristofaro, Nobili, F., Mazzuca, N., Baldari, S., Eleopra, R., Bestetti, A., Benti, R., Varrone, A., Volterrani, D., Massa, R., Stocchi, F., Schillaci, O., Dore, F., Zibetti, M., Castellano, G., Battista, S. G., and Giorgetti, G.
- Subjects
Male ,Pathology ,Parkinson's disease ,Parkinson’s disease ,Vascular parkinsonism ,Dopamine transporter SPECT imaging ,Gastroenterology ,Severity of Illness Index ,Antiparkinson Agents ,Cohort Studies ,Levodopa ,Basal ganglia ,80 and over ,Medicine ,Tomography ,Aged, 80 and over ,Parkinsonism ,Parkinson Disease ,Magnetic Resonance Imaging ,Tomography, Emission-Computed, Single-Photon ,Humans ,Corpus Striatum ,Aged ,Cerebrovascular Disorders ,Cross-Sectional Studies ,Dopamine Plasma Membrane Transport Proteins ,Middle Aged ,Parkinsonian Disorders ,Female ,MR Imaging ,Neurology ,Frontal lobe ,Settore MED/26 - Neurologia ,medicine.symptom ,medicine.drug ,MR imaging ,medicine.medical_specialty ,Internal medicine ,Severity of illness ,business.industry ,Vascular disease ,medicine.disease ,Dyskinesia ,nervous system ,Neurology (clinical) ,Emission-Computed ,Geriatrics and Gerontology ,business ,Single-Photon - Abstract
Background The observation of gait abnormalities, parkinsonism and vascular lesions in elderly patients is often reported as vascular parkinsonism (VP). However the status of striatal dopamine transporter (DAT) and the effects of brain vascular lesions on motor features and levodopa responsiveness are poorly defined. Methods We recorded clinical features, chronic response to levodopa and vascular risk factors in a cross-sectional cohort of consecutive elderly patients with possible Parkinson's disease (PD) or VP recruited in 20 centers in Italy. Results We included a total of 158 patients. Onset of motor symptoms was asymmetric in 93 (59%) and symmetric in 65 patients (41%). Symmetric motor onset was associated with greater disease severity. Chronic levodopa response was positive in 75 (47.8%) and negative in 82 patients (52.2%). A negative response to levodopa was associated with greater frequency of symmetric onset of motor symptoms, worst disease severity, absence of dyskinesia and greater number of vascular risk factors. Frontal lobe showed largest vascular load. Striatal DAT was normal in 48 (30.4%) and abnormal in 110 (69.6%) patients. Patients with normal DAT binding showed higher vascular load at MRI. Significant predictive factors of worst disease severity and negative response to levodopa were hypertension, vascular lesions in basal ganglia/periventricular regions, and normal DAT uptake. Conclusions Multiple cerebral vascular lesions modify clinical presentation and severity in patients with parkinsonism and this is underlined by specific risk factors primarily hypertension. Striatal DAT assessment is helpful in identifying patients where therapy benefit is less likely.
- Published
- 2012
34. PINK1heterozygous rare variants: prevalence, significance and phenotypic spectrum
- Author
-
Marongiu R., Ferraris A., Ialongo T., Michiorri S., Soleti F., Ferrari F., Elia A. E., Ghezzi D., Albanese A., Altavista M. C., Antonini A., Barone P., Brusa L., Pellecchia M. T., Pezzoli G., Stanzione P., Tinazzi M., Zecchinelli A., Zeviani M., Cassetta E., Garavaglia B., Dallapiccola B., Bentivoglio A. R., Valente E. M., Italian PD Study Group, CORTELLI, PIETRO, MARTINELLI, PAOLO, SCAGLIONE, CESA LORELLA MARIA, Marongiu R., Ferraris A., Ialongo T., Michiorri S., Soleti F., Ferrari F., Elia A.E., Ghezzi D., Albanese A., Altavista M.C., Antonini A., Barone P., Brusa L., Cortelli P., Martinelli P., Pellecchia M.T., Pezzoli G., Scaglione C., Stanzione P., Tinazzi M., Zecchinelli A., Zeviani M., Cassetta E., Garavaglia B., Dallapiccola B., Bentivoglio A.R., Valente E.M., Italian PD Study Group., Marongiu, R, Ferraris, A, Ialongo, T, Michiorri, S, Soleti, F, Ferrari, F, Elia, Ae, Ghezzi, D, Albanese, A, Altavista, Mc, Antonini, A, Barone, Paolo, Brusa, L, Cortelli, P, Martinelli, P, Pellecchia, Mt, Pezzoli, G, Scaglione, C, Stanzione, P, Tinazzi, M, Zecchinelli, A, Zeviani, M, Cassetta, E, Garavaglia, B, Dallapiccola, B, Bentivoglio, Ar, Valente, Em, and Italian PD Study, G. r. o. u. p.
- Subjects
Adult ,Male ,Heterozygote ,Autosomal recessive parkinsonism ,Heterozygous rare variants ,Parkinson disease ,PINK1 ,Aged ,Aged, 80 and over ,Amino Acid Sequence ,Case-Control Studies ,Female ,Gene Frequency ,Genes, Recessive ,Humans ,Italy ,Middle Aged ,Molecular Sequence Data ,Parkinson Disease ,Phenotype ,Protein Kinases ,Retrospective Studies ,Sequence Homology, Amino Acid ,Genetic Variation ,Genetics ,Genetics (clinical) ,Sequence Homology ,Context (language use) ,Biology ,Compound heterozygosity ,symbols.namesake ,Genetic variation ,80 and over ,medicine ,Recessive ,Allele frequency ,Parkinsonism ,heterozygous rare variants ,Case-control study ,Odds ratio ,medicine.disease ,Amino Acid ,autosomal recessive parkinsonism ,Genes ,Immunology ,Mendelian inheritance ,symbols ,Settore MED/26 - Neurologia - Abstract
Heterozygous rare variants in the PINK1 gene, as well as in other genes causing autosomal recessive parkinsonism, have been reported both in patients and healthy controls. Their pathogenic significance is uncertain, but they have been suggested to represent risk factors to develop Parkinson disease (PD). The few large studies that assessed the frequency of PINK1 heterozygotes in cases and controls yielded controversial results, and the phenotypic spectrum is largely unknown. We retrospectively analyzed the occurrence of PINK1 heterozygous rare variants in over 1100 sporadic and familial patients of all onset ages and in 400 controls. Twenty patients and 6 controls were heterozygous, with frequencies (1.8% vs. 1.5%) not significantly different in the two groups. Clinical features of heterozygotes were indistinguishable to those of wild-type patients, with mean disease onset 10 years later than in carriers of two mutations but worse disease progression. A meta-analysis indicated that, in PINK1 heterozygotes, the PD risk is only slightly increased with a non significant odds ratio of 1.62. These findings suggest that PINK1 heterozygous rare variants play only a minor susceptibility role in the context of a multifactorial model of PD. Hence, their significance should be kept distinct from that of homozygous/compound heterozygous mutations, that cause parkinsonism inherited in a mendelian fashion. © 2008 Wiley-Liss, Inc.
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- 2008
35. Diagnostic agreement in psychogenic movement disorders
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Morgante, F, Bovi, T, Fasano, A, Pellecchia, M, Rizzo, G, Scaglione, C, Cossu, G, Modugno, N, Arabia, G, Avanzino, L, Ciclia, R, Dell'Aquila, C, Elia, A, Marinelli, L, Abbruzzese, G, Berardelli, A, Defazio, G, Fabbrini, G, Girlanda, P, Iliceto, G, Martinelli, P, Nicoletti, G, Tinazzi, M, Zappia, Mario, Boero, G, Cantalupo, G, DI LEO, R, Luigetti, M, Tortora, C, Edwards, M, Espay, A, Mir, P, and Martino, D.
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- 2010
36. Clinical and spect dat-scan correlations of drug-induced Parkinsonism in patients with schizophrenia: an italian multicenter study
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Tinazzi, M, Bovi, T, Barbui, C, Cipriani, A, Cannas, A, Solla, P, Nicoletti, Alessandra, Zappia, Mario, Morgante, L, Morgante, F, Pacchetti, C, Sciarretta, M, Dall'Occhio, C, Rossi, S, Malentacchi, M, Ceravolo, R, Vanelli, F, Moretto, G, and Fiaschi, A.
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- 2010
37. ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease
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Di Fonzo, A, Fabrizio, E, Thomas, A, Fincati, E, Marconi, R, Tinazzi, M, Breedveld, Gj, Simons, Ej, Chien, Hf, Ferreira, Jj, Horstink, Mw, Abbruzzese, G, Borroni, B, Cossu, G, Dalla Libera, A, Fabbrini, G, Guidi, M, De Mari, M, Lopiano, L, Martignoni, E, Marini, P, Onofrj, M, Padovani, A, Stocchi, F, Toni, V, Sampaio, C, Barbosa, Er, Meco, G, Antonini, A, Oostra BA, Bonifati V., Di Fonzo A., Chien H.F., Socal M., Giraudo S., Tassorelli C., Illiceto G., Fabbrini G., Marconi R., Fincati E., Abbruzzese G., Marini P., Squitieri F., Horstink M.W., Montagna P., Libera A.D., Stocchi F., Goldwurm S., Ferreira J.J., Meco G., Martignoni E., Lopiano L., Jardim L.B., OOstra B.A., Barbosa E.R., The Italian Parkinson Genetics Network, Bonifati V., Erasmus MC other, and Clinical Genetics
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Genotype ,assessment ,DNA Mutational Analysis ,Mutation, Missense ,patients ,Central nervous system disease ,Cohort Studies ,Diagnosis, Differential ,Degenerative disease ,Parkinsonian Disorders ,medicine ,Prevalence ,Dementia ,Missense mutation ,Humans ,Genetic Predisposition to Disease ,young onset Parkinson disease ,Genetic Testing ,Age of Onset ,juvenile parkinsonism ,Child ,Genetics ,business.industry ,Parkinsonism ,ATP13A2 gene mutations ,Brain ,Parkinson Disease ,Middle Aged ,medicine.disease ,Young onset Parkinson disease ,Proton-Translocating ATPases ,Phenotype ,Italy ,Kufor Rakeb syndrome ,Female ,Neurology (clinical) ,business ,Brazil - Abstract
To assess the prevalence, nature, and associated phenotypes of ATP13A2 gene mutations among patients with juvenile parkinsonism (onset21 years) or young onset (between 21 and 40 years) Parkinson disease (YOPD).We studied 46 patients, mostly from Italy or Brazil, including 11 with juvenile parkinsonism and 35 with YOPD. Thirty-three cases were sporadic and 13 had positive family history compatible with autosomal recessive inheritance. Forty-two had only parkinsonian signs, while four (all juvenile-onset) had multisystemic involvement. The whole ATP13A2 coding region (29 exons) and exon-intron boundaries were sequenced from genomic DNA.A novel homozygous missense mutation (Gly504Arg) was identified in one sporadic case from Brazil with juvenile parkinsonism. This patient had symptoms onset at age 12, levodopa-responsive severe akinetic-rigid parkinsonism, levodopa-induced motor fluctuations and dyskinesias, severe visual hallucinations, and supranuclear vertical gaze paresis, but no pyramidal deficit nor dementia. Brain CT scan showed moderate diffuse atrophy. Furthermore, two Italian cases with YOPD without atypical features carried a novel missense mutation (Thr12Met, Gly533Arg) in single heterozygous state.We confirm that ATP13A2 homozygous mutations are associated with human parkinsonism, and expand the associated genotypic and clinical spectrum, by describing a homozygous missense mutation in this gene in a patient with a phenotype milder than that initially associated with ATP13A2 mutations (Kufor-Rakeb syndrome). Our data also suggest that ATP13A2 single heterozygous mutations might be etiologically relevant for patients with YOPD and further studies of this gene in Parkinson disease are warranted.
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- 2007
38. Successful botulinum toxin treatment fo oropharyngeal dysphagia in Parkinson’s disease
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Restivo, Da, Patti, Francesco, Pappalardo, A, Liberto, A, Tinazzi, M, Marchese Ragona, R, and Zappia, Mario
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- 2005
39. Placebo-Induced Changes in Excitatory and Inhibitory Corticospinal Circuits during Motor Performance
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Fiorio, M., primary, Emadi Andani, M., additional, Marotta, A., additional, Classen, J., additional, and Tinazzi, M., additional
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- 2014
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40. Impairment of the rubber hand illusion in focal hand dystonia
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Fiorio, M., primary, Weise, D., additional, Onal-Hartmann, C., additional, Zeller, D., additional, Tinazzi, M., additional, and Classen, J., additional
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- 2011
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41. Defective temporal processing of sensory stimuli in DYT1 mutation carriers: a new endophenotype of dystonia?
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Fiorio, M., primary, Gambarin, M., additional, Valente, E. M., additional, Liberini, P., additional, Loi, M., additional, Cossu, G., additional, Moretto, G., additional, Bhatia, K. P., additional, Defazio, G., additional, Aglioti, S. M., additional, Fiaschi, A., additional, and Tinazzi, M., additional
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- 2006
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42. Selective impairment of hand mental rotation in patients with focal hand dystonia
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Fiorio, M., primary, Tinazzi, M., additional, and Aglioti, S.M., additional
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- 2005
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43. Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome
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Tinazzi, M, primary
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- 1998
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44. Effect of Balance Training on Postural Instability in Patients With Idiopathic Parkinson’s Disease.
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Smania N, Corato E, Tinazzi M, Stanzani C, Fiaschi A, Girardi P, and Gandolfi M
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- 2010
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45. Influence of somatosensory input on paroxysmal activity on benign rolandic epilepsy with 'extreme somatosensory evoked potentials'.
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Manganotti P, Miniussi C, Santorum E, Tinazzi M, Bonato C, Marzi CA, Fiaschi A, Bernardian BD, and Zanette G
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- 1998
46. Influence of somatosensory input on paroxysmal activity in benign rolandic epilepsy with 'extreme somatosensory evoked potentials'.
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Manganotti, P, Miniussi, C, Santorum, E, Tinazzi, M, Bonato, C, Marzi, CA, Fiaschi, A, Dalla Bernardina, B, and Zanette, G
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- 1998
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47. Active finger extension: a simple movement predicting recovery of arm function in patients with acute stroke.
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Smania N, Paolucci S, Tinazzi M, Borghero A, Manganotti P, Fiaschi A, Moretto G, Bovi P, Gambarin M, Smania, Nicola, Paolucci, Stefano, Tinazzi, Michele, Borghero, Anna, Manganotti, Paolo, Fiaschi, Antonio, Moretto, Giuseppe, Bovi, Paolo, and Gambarin, Mattia
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- 2007
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48. Time for a consensus conference on pain in neurorehabilitation
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Sandrini, G, Tamburin, S, Paolucci, S, Boldrini, P, Saraceni, V, Smania, N, Italian Consensus Conference on Pain in Neurorehabilitation, Agostini, M, Alfonsi, E, Aloisi, A, Alvisi, E, Aprile, I, Armando, M, Avenali, M, Azicnuda, E, Barale, F, Bartolo, M, Bergamaschi, R, Berlangieri, M, Berlincioni, V, Berliocchi, L, Berra, E, Berto, G, Bonadiman, S, Bonazza, S, Bressi, F, Brugnera, A, Brunelli, S, Buzzi, M, Cacciatori, C, Calvo, A, Cantarella, C, Caraceni, A, Carone, R, Carraro, E, Casale, R, Castellazzi, P, Castelnuovo, G, Castino, A, Cella, M, Cerbo, R, Chiò, A, Ciotti, C, Cisari, C, Coraci, D, Dalla Toffola, E, Defazio, G, De Icco, R, Del Carro, U, Dell’Isola, A, De Tanti, A, D’Ippolito, M, Fazzi, E, Federico, A, Ferrari, A, Ferrari, S, Ferraro, F, Formaglio, F, Formisano, R, Franzoni, S, Gajofatto, F, Gandolfi, M, Gardella, B, Geppetti, P, Giammò, A, Gimigliano, R, Giusti, E, Greco, E, Ieraci, V, Invernizzi, M, Jacopetti, M, Jedrychowska, I, Lacerenza, M, La Cesa, S, Lobba, D, Magrinelli, F, Mandrini, S, Manera, U, Manzoni, G, Marchettini, P, Marchioni, E, Mariotto, S, Martinuzzi, A, Masciullo, M, Mezzarobba, S, Miotti, D, Modenese, A, Molinari, M, Monaco, S, Morone, G, Nappi, R, Negrini, S, Pace, A, Padua, L, Pagliano, E, Palmerini, V, Pazzaglia, C, Pecchioli, C, Pietrabissa, G, Picelli, A, Polli, A, Porro, C, Porru, D, Romano, M, Roncari, L, Rosa, R, Saccavini, M, Sacerdote, P, Saviola, D, Schenone, A, Schweiger, V, Scivoletto, G, Solaro, C, Spallone, V, Springhetti, I, Tassorelli, C, Tinazzi, M, Togni, R, Torre, M, Torta, R, Traballesi, M, Trabucco, E, Tramontano, M, Truini, A, Tugnoli, V, Turolla, A, Valeriani, M, Vallies, G, Verzini, E, Vottero, M, Mario, P, Sandrini, Giorgio, Tamburin, Stefano, Paolucci, Stefano, Boldrini, Paolo, Saraceni, Vincenzo M., Smania, Nicola, Agostini, Michela, Alfonsi, Enrico, Aloisi, Anna Maria, Alvisi, Elena, Aprile, Irene, Armando, Michela, Avenali, Micol, Azicnuda, Eva, Barale, Francesco, Bartolo, Michelangelo, Bergamaschi, Roberto, Berlangieri, Mariangela, Berlincioni, Vanna, Berliocchi, Laura, Berra, Eliana, Berto, Giulia, Bonadiman, Silvia, Bonazza, Sara, Bressi, Federica, Brugnera, Annalisa, Brunelli, Stefano, Buzzi, Maria Gabriella, Cacciatori, Carlo, Calvo, Andrea, Cantarella, Cristina, Caraceni, Augusto Tommaso, Carone, Roberto, Carraro, Elena, Casale, Roberto, Castellazzi, Paola, Castelnuovo, Gianluca, Castino, Adele, Cella, Monica, Cerbo, Rosanna, Chiò, Adriano, Ciotti, Cristina, Cisari, Carlo, Coraci, Daniele, Toffola, Elena Dalla, Defazio, Giovanni, De Icco, Roberto, Del Carro, Ubaldo, Dell'Isola, Andrea, De Tanti, Antonio, D'Ippolito, Mariagrazia, Fazzi, Elisa, Federico, Angela, Ferrari, Adriano, Ferrari, Sergio, Ferraro, Francesco, Formaglio, Fabio, Formisano, Rita, Franzoni, Simone, Gajofatto, Francesca, Gandolfi, Marialuisa, Gardella, Barbara, Geppetti, Pierangelo, Giammò, Alessandro, Gimigliano, Raffaele, Giusti, Emanuele Maria, Greco, Elena, Ieraci, Valentina, Invernizzi, Marco, Jacopetti, Marco, Jedrychowska, Iwona, Lacerenza, Marco, La Cesa, Silvia, Lobba, Davide, Magrinelli, Francesca, Mandrini, Silvia, Manera, Umberto, Manzoni, Gian Mauro, Marchettini, Paolo, Marchioni, Enrico, Mariotto, Sara, Martinuzzi, Andrea, Masciullo, Marcella, Mezzarobba, Susanna, Miotti, Danilo, Modenese, Angela, Molinari, Marco, Monaco, Salvatore, Morone, Giovanni, Nappi, Rossella, Negrini, Stefano, Pace, Andrea, Padua, Luca, Pagliano, Emanuela, Palmerini, Valerio, Pazzaglia, Costanza, Pecchioli, Cristiano, Pietrabissa, Giada, Picelli, Alessandro, Polli, Andrea, Porro, Carlo Adolfo, Porru, Daniele, Romano, Marcello, Roncari, Laura, Rosa, Riccardo, Saccavini, Marsilio, Sacerdote, Paola, Saviola, Donatella, Schenone, Angelo, Schweiger, Vittorio, Scivoletto, Giorgio, Solaro, Claudio, Spallone, Vincenza, Springhetti, Isabella, Tassorelli, Cristina, Tinazzi, Michele, Togni, Rossella, Torre, Monica, Torta, Riccardo, Traballesi, Marco, Trabucco, Erika, Tramontano, Marco, Truini, Andrea, Tugnoli, Valeria, Turolla, Andrea, Valeriani, Massimiliano, Vallies, Gabriella, Verzini, Elisabetta, Vottero, Mario, and Zerbinati, Paolo
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Male ,peripheral neuropathy ,Time Factors ,Physical Therapy ,consensus conference ,Consensus Development Conferences as Topic ,Sports Therapy and Rehabilitation ,Settore M-PSI/08 - PSICOLOGIA CLINICA ,pain ,diabetic neuropathy ,neurorehabilitation ,neuropathic pain ,Settore MED/13 - Endocrinologia ,Humans ,Pain Management ,Randomized Controlled Trials as Topic ,Physical Therapy, Sports Therapy and Rehabilitation ,Rehabilitation ,Female ,Italy ,Neurological Rehabilitation ,neurorehabilitation, pain, consensus conference ,Settore MED/34 - Medicina Fisica e Riabilitativa ,Settore MED/26 - Neurologia ,Human
49. Are indexes of arm recovery related to daily life autonomy in patients with stroke?
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Smania N, Gambarin M, Tinazzi M, Picelli A, Fiaschi A, Moretto G, Bovi P, and Stefano Paolucci
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Adult ,Aged, 80 and over ,Male ,Rehabilitation ,Stroke Rehabilitation ,Outcome assessment (health care), Disability evaluation, Prognosis, Rehabilitation ,Recovery of Function ,Middle Aged ,Prognosis ,Stroke ,Disability Evaluation ,Activities of Daily Living ,Outcome Assessment, Health Care ,Arm ,Outcome assessment (health care) ,Humans ,Female ,Aged - Abstract
The level of daily life autonomy in patients with stroke may be related to recovery of affected arm function. The aim of the study was to assess whether four simple bedside indexes of arm recovery can predict levels of autonomy in daily life activities.A consecutive sample of 48 patients presenting with upper limb paresis/plegia in the acute stage after stroke was selected. Patients underwent five evaluation sessions at 7, 14, 30, 90 and 180 days after stroke. Forward stepwise multiple regression analysis was used to clarify the role of four potential predictors of upper limb recovery (active finger extension, shoulder abduction, shoulder shrug and hand movement scales). Dependent variables in these models were the Barthel Index score and sub-items of the Burke-Fahn-Marsden Scale.The active finger extension scale showed a highly significant statistical correlation with patient performance in nearly all outcome measures. The shoulder shrug correlated with the BI score, and with the dressing and hygiene Burke-Fahn-Marsden Scale sub-items. Shoulder abduction and hand movement scale played only a minor role.The active finger extension scale proved to be a strong early predictor of recovery of daily life autonomy in patients with stroke. This finding could be important in order to planning a specific rehabilitation treatment after the onset.
50. Opinion, knowledge, and clinical experience with functional neurological disorders among Italian neurologists: results from an online survey
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Mario Zappia, Francesca Calabria, Mirta Fiorio, Gianluigi Mancardi, Annachiara Cagnin, Domenico Marco Bonifati, Maurizio Corbetta, Michele Tinazzi, Emanuele Turinese, Angela Marotta, Leonardo Lopiano, Gioacchino Tedeschi, Francesco Teatini, Bruno Bonetti, Pietro Cortelli, Bruno Giometto, Silvia Vittoria Guidoni, Lucia Tesolin, Fabio Marchioretto, Maria Pellegrini, Alfredo Berardelli, Alessandro P. Burlina, Tinazzi, M., Fiorio, M., Berardelli, A., Bonetti, B., Bonifati, D. M., Burlina, A., Cagnin, A., Calabria, F., Corbetta, M., Cortelli, P., Giometto, B., Guidoni, S. V., Lopiano, L., Mancardi, G., Marchioretto, F., Pellegrini, M., Teatini, F., Tedeschi, G., Tesolin, L., Turinese, E., Zappia, M., Marotta, A., Tinazzi M., Fiorio M., Berardelli A., Bonetti B., Bonifati D.M., Burlina A., Cagnin A., Calabria F., Corbetta M., Cortelli P., Giometto B., Guidoni S.V., Lopiano L., Mancardi G., Marchioretto F., Pellegrini M., Teatini F., Tedeschi G., Tesolin L., Turinese E., Zappia M., and Marotta A.
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medicine.medical_specialty ,Neurology ,Conversion disorders ,Psychological intervention ,Context (language use) ,Neurologist ,Education ,Functional neurological disorders ,Neurological practice ,Survey ,Humans ,Neurologists ,Surveys and Questionnaires ,Conversion Disorder ,Nervous System Diseases ,medicine ,Surveys and Questionnaire ,Psychogenic disease ,Psychiatry ,business.industry ,Professional development ,Mental illness ,medicine.disease ,Patient management ,Neurology (clinical) ,Psychological aspects ,Functional neurological disorder ,business ,Human - Abstract
Background Functional neurological disorders (FND) are disabling medical conditions commonly seen in neurological practice. Neurologists play an essential role in managing FND, from establishing a diagnosis to coordination of multidisciplinary team-based treatment for patients. With this study, we investigated the knowledge and the clinical experience of Italian neurologists in managing patients with FND. Methods Members of the Italian Society of Neurology were invited via e-mail to participate in this ad hoc online survey; 492 questionnaires were returned completed. Results The term “Functional neurological disorders” in reference to FND was used more frequently than other psychological (e.g., psychogenic or conversion), or descriptive terms (e.g., non-organic or stress-related). When speaking with patients, the respondents stated that they preferred explaining symptoms based on abnormal functioning of the nervous system than discussing mental illness and that they would refer their patient to a psychologist rather than to a psychiatrist. Few considered that physiotherapy and psychiatric interventions are useful approaches to treating FND. Some believed that patients simulate their symptoms. Conclusions Overall, the responses suggest that knowledge about scientific advances in FND is somewhat sparse. A psychiatric-centered view of FND opens the way to an approach in which neurobiological and psychological aspects constitute essential factors of the condition. In this context, professional education could improve understanding of FND and optimize patient management.
- Published
- 2022
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