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Purpose Two-dimensional antiscatter grids (2DASG) for cone beam computed tomography (CBCT) is a new area of research to reduce scatter intensity, and consequently improve CBCT image quality. One of the challenges in implementation of 2DASGs is their septa shadows that are impinged on the projections. If these artifacts are not corrected, they may lead to ring artifacts in CBCT images. In this work, we present a novel method to suppress ring artifacts in FPD-based CBCT images. Methods Briefly, our method first detects the locations of 2DASG's septa shadows in projections and then, reduces projection pixel values in septa shadows iteratively until a residual-based convergence criterion is met. To suppress the 2DASG's septa shadows, we developed a total variation minimization (TVM) formulation, referred to as adaptive-diffusive total variation minimization (adTVM), where the diffusivity regularization parameter was adaptively adjusted during each iteration based on the magnitude of the local pixel gradients. To test our method, we have acquired CBCT scans of phantoms using three 2DASG prototypes with different grid geometries. Projections were acquired with a linac mounted CBCT system, operated in offset detector geometry. These projections were then corrected in the following steps: first, projections were corrected using a gantry angle-specific gain correction map; next, projections were corrected by applying our adTVM method. CBCT images were reconstructed using FDK filtered backprojection algorithm. To evaluate adTVM's performance, pixel value statistics and contrast-to-noise ratio (CNR) were compared in CBCT images corrected with and without our adTVM method. Results Without our adTVM method, all three 2DASG prototypes introduced ring artifacts with varying intensities in CBCT images. With our method, significant reduction in ring artifacts was observed in all test cases. Standard deviation of CT numbers was reduced by 7-74% in uniform density phantom CBCT images, CNR was increased by 8-67%, and CT number accuracy of contrast objects embedded in the phantom was preserved. Conclusion We propose a new method to suppress ring artifacts caused by the 2DASG's septa shadows in CBCT images. Our initial investigations indicated that adTVM method could substantially reduce such ring artifacts while preserving CT number accuracy and maintaining good spatial resolution. Therefore, our method may potentially play an important role in enabling the implementation of 2DASGs in flat panel detector based CBCT systems.

PURPOSE We have been investigating two-dimensional (2D) antiscatter grids (2D ASGs) to reduce scatter fluence and improve image quality in cone beam computed tomography (CBCT). In this work, two different aspects of 2D ASGs, their scatter rejection and correction capability, were investigated in CBCT experiments. To correct residual scatter transmitted through the 2D ASG, it was used as a scatter measurement device with a novel method: grid-based scatter sampling. METHODS Three focused 2D ASG prototypes with grid ratios of 8, 12, and 16 were developed for linac-mounted offset detector CBCT geometry. In the first phase, 2D ASGs were used as a scatter rejection device, and the effect of grid ratio on CT number accuracy and contrast-to-noise ratio (CNR) evaluated in CBCT images. In the second phase, a grid-based scatter sampling method which exploits the signal modulation characteristics of the 2D ASG's septal shadows to measure and correct residual scatter transmitted through the grid was implemented. To evaluate CT number accuracy, the percent change in CT numbers was measured by changing the phantom from head to pelvis size and configuration. RESULTS When 2D ASG was used as a scatter rejection device, CT number accuracy increased and the CT number variation due to change in phantom dimensions was reduced from 23% to 2-6%. A grid ratio of 16 yielded the lowest CT number variation. All three 2D ASGs yielded improvement in CNR, up to a factor of two in pelvis-sized phantoms. When 2D ASG prototypes were used for both scatter rejection and correction, CT number variations were reduced further, to 1.3-2.6%. In comparisons with a clinical CBCT system and a high-performance radiographic ASG, 2D ASG provided higher CT number accuracy under the same imaging conditions. CONCLUSIONS When 2D ASG is used solely as a scatter rejection device, substantial improvement in CT number accuracy can be achieved by increasing the grid ratio. Two-dimensional ASGs also provided significant CNR improvement even at lower grid ratios. Two-dimensional ASGs used in conjunction with the grid-based scatter sampling method provided further improvement in CT number accuracy, irrespective of the grid ratio, while preserving 2D ASGs' capacity to improve CNR. The combined effect of scatter rejection and residual scatter correction by 2D ASG may accelerate implementation of new techniques in CBCT that require high quantitative accuracy, such as radiotherapy dose calculation and dual energy CBCT.

PURPOSE Scattered radiation remains to be a major cause of image quality degradation in Flat Panel Detector (FPD)-based Cone-beam computed tomography (CBCT). We have been investigating a novel two-dimensional antiscatter grid (2D-ASG) concept to reduce scatter intensity, and hence improve CBCT image quality. We present the first CBCT imaging experiments performed with the 2D-ASG prototype, and demonstrate its efficacy in improving CBCT image quality. METHODS A 2D-ASG prototype with septa focused to x-ray source was additively manufactured from tungsten and mounted on a Varian TrueBeam CBCT system. CBCT projections of phantoms were acquired with an offset detector geometry using TrueBeam's "developer" mode. To minimize the effect of gantry flex, projections were gain corrected on angle-specific bases. CBCT images were reconstructed using a filtered backprojection algorithm and image quality improvement was quantified by measuring contrast-to-noise ratio (CNR) and CT number accuracy in images acquired with no antiscatter grid (NO-ASG), conventional one dimensional antiscatter grid (1D-ASG), and the 2D-ASG prototype. RESULTS A significant improvement in contrast resolution was achieved using our 2D-ASG prototype compared to results of 1D-ASG and NO-ASG acquisitions. Compared to NO-ASG and 1D-ASG experiments, the CNR of material inserts improved by as much as 86% and 54% respectively. Using 2D-ASG, CT number underestimation in water equivalent material section of the phantom was reduced by up to 325 HU when compared to NO-ASG and up to 179 HU when compared to 1D-ASG. CONCLUSION We successfully performed the first CBCT imaging experiments with a 2D-ASG prototype. 2D-ASG provided significantly higher CT number accuracy, higher CNR, and diminished scatter-induced image artifacts in qualitative evaluations. We strongly believe that utilization of a 2D-ASG may potentially lead to better soft tissue visualization in CBCT and may enable novel clinical applications that require high CT number accuracy.

Aim High fraction of scattered radiation in cone-beam CT (CBCT) imaging degrades CT number accuracy and visualization of low contrast objects. To suppress scatter in CBCT projections, we developed a focused, two-dimensional antiscatter grid (2DASG) prototype. In this work, we report on the primary and scatter transmission characteristics of the 2DASG prototype aimed for linac mounted, offset detector geometry CBCT systems in radiation therapy, and compared its performance to a conventional one-dimensional ASG (1DASG). Methods The 2DASG is an array through-holes separated by 0.1 mm septa that was fabricated from tungsten using additive manufacturing techniques. Through-holes’ focusing geometry was designed for offset detector CBCT in Varian TrueBeam system. Two types of ASGs were evaluated: a) a conventional 1DASG with a grid ratio of 10, b) the 2DASG prototype with a grid ratio of 8.2. To assess the scatter suppression performance of both ASGs, Scatter-to-primary ratio (SPR) and scatter transmission fraction (Ts) were measured using the beam stop method. Scatter and primary intensities were modulated by varying the phantom thickness between 10 and 40 cm. Additionally, the effect of air gap and bow tie (BT) filter on SPR and Ts were evaluated. Average primary transmission fraction (TP) and pixel specific primary transmission were also measured for both ASGs. To assess the effect of transmission characteristics on projection image signal-to-noise ratio (SNR) improvement factor was calculated. Improvement in contrast to noise ratio (CNR) was demonstrated using a low contrast object. Results In comparison to 1DASG, 2DASG reduced SPRs by a factor of 3 to 6 across the range of phantom setups investigated. Ts values for 1D and 2DASGs were in the range of 21 to 29%, and 5 to 14%, respectively. 2DASG continued to provide lower SPR and Ts at increased air gap and with BT filter. Tp of 1D and 2DASGs were 70.6% and 84.7%, respectively. Due to the septal shadow of the 2DASG, its pixel specific primary transmission values varied between 32.5% and 99.1%. With respect to 1DASG, 2DASG provided up to factor of 1.7 more improvement in SNR across the SPR range investigated. Moreover, 2DASG provided improved visualization of low contrast objects with respect to 1DASG and NOASG setups. Conclusions When compared to a conventional 1DASG, 2DASG prototype provided noticeably lower SPR and Ts values, indicating its superior scatter suppression performance. 2DASG also provided 19% higher average primary transmission that was attributed to the absence of interseptal spacers and optimized grid geometry. Our results indicate that the combined effect of lower scatter and higher primary transmission provided by 2DASG may potentially translate into more accurate CT numbers and improved contrast resolution in CBCT images. This article is protected by copyright. All rights reserved.

Design, calibration, and operation of a system for drop-and-catch (DnC) calorimetry on oxides from temperature above 1500°C are described. This system allows the measurement of heat contents and heats of fusion by drop calorimetry of small (100 mg or less) samples held by containerless levitation at high temperature and dropped in a calorimeter at room temperature. The spheroids, 2-3 mm in diameter, prepared by laser melting of powders, are aerodynamically levitated in a splittable nozzle levitator and laser heated to the desired temperature monitored by radiation thermometry. The sample is dropped by splitting the nozzle and caught by splittable water-cooled calorimetric plates at 25°C, which provide complete enclosure of the sample to avoid heat loss by radiation. The drop time is ~0.1 seconds, calorimeter equilibration time after the drop is ~15 minute. DnC experiments are automated with software-controlled laser power and programmable delay between splitting the nozzle and catching the sample. The fusion enthalpy of Al2O3 measured by DnC calorimeter, 120 ± 10 kJ/mol, agrees well with previously reported values. The system can be used for measurements of fusion enthalpies of refractory oxides amenable to laser heating as well as for splat quenching of oxide melts.

To suppress scatter in cone beam computed tomography (CBCT), two-dimensional antiscatter grids (2D grid) have been recently proposed. In this work, we developed several grid prototypes with higher grid ratios and smaller grid pitches than previous designs, and quantified their primary and scatter transmission properties in the context of CBCT for radiation therapy. Three focused 2D grid prototypes were developed with grid ratios at 12 and 16, and grid pitches at 2 and 3 mm. Their scatter transmission properties were measured between 80-140 kVp, and benchmarked against a high performance radiographic grid (1D grid) using a Varian TrueBeam CBCT system. The effect of source-grid misalignment on the primary transmission and the improvement in contrast-to-noise ratio (CNR) were also evaluated. Changing the grid pitch from two to three mm increased the average primary transmission from 84% to 89%. Maximum scatter-to-primary ratio (SPR) with grid ratio of 12 was 0.3, and increasing the grid ratio to 16 reduced SPR by 30%. A 10 mm misalignment in 2D grid position led to a 6%-8% reduction in average primary transmission, and reduction was more pronounced for the higher grid ratio. 2D grids provided up to factor of seven lower SPR and 21% better primary transmission than the 1D grid, and their scatter transmission exhibited lower energy dependence. While 2D grids provided up to factor of 2.3 higher CNR improvement, a significant variation in CNR improvement was not observed among different grid pitch and ratios. In summary, grid ratio of 16 and grid pitch of 2 mm can keep SPRs below 0.2 even in high scatter conditions, while keeping primary transmission fractions above 80%, key benefits of the investigated 2D grids in improving image quality of CBCT. However, such grids require precise alignment in source-grid geometry during CBCT acquisitions. This study also implies that 2D grids can provide substantially better scatter suppression and primary transmission than high-performance 1D grids currently available.