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The remotely controlled shape memory behaviors of a two-dimensional (2D) sheet to controlled helix structure upon external stimuli is of great significance in the field of smart materials. Herein, we devise a strategy to fabricate a series of shape memory polycaprolactone/[W.sub.18][O.sub.49] nanowire film via highly efficient UV-triggered thiol-acrylate click chemistry. The resultant polymer composites exhibited desirable photothermal transfer efficiency and can enable rapid temperature increase over the melting temperature of polymeric matrix, thus remotely actuating shape transformation within 8 s. Owing to the well- defined architecture of the polymer network, the fabricated elastic composite film exhibited a high degree of crystallinity and showed excellent shape memory properties with [R.sub.f] of 93.12% and [R.sub.r] of 95.32%. Remarkably, under a 160 mW/[cm.sup.2] simulated sunlight illumination, the transformation of flat 2D film into 3D chiral actuators is driven by designing anisotropic bilayer thin sheet, and it yields right- and left-handed helix. This work will pave the way for designing biomimetic flexible actuators toward multifunctional shape-shifting devices. Highlights * Shape memory polycaprolactone/[W.sub.18][O.sub.49] nanowires composite film is fabricated via UV-triggered thiol-ene click chemistry. * Polymer composites exhibit light-activated shape memory behaviors. * The composite films show excellent shape fixity and shape recovery ratio based on the well-defined network. * The shape morphing behaviors of a flexible 2D bilayer strip into 3D chiral actuators are achieved. KEYWORDS flexible actuators, polycaprolactone, shape memory polymers, stimuli- responsive polymers, 1 | INTRODUCTION Stimuli-responsive morphing materials belong to one kind of molecules with 'intelligent' behavior, which can generate corresponding response signals upon the stimuli of heat, light, electric field, etc. [...]

In order to obtain the novel poly(ε-caprolactone) (PCL) cross-linked networks with good shape memory properties, the cross-linked networks of PCL with different molecular weights were prepared by thiol-ene click chemistry method, and its microstructure, thermal properties, mechanical properties and shape memory properties were characterized. The results show that the hydroxyl end of PCL was successfully converted to acrylate-terminated PCL, and almost all the samples show perfect cross-linked network, and the cross-linked polymer has a thermally induced shape memory effect; with the increase of the molecular weight of PCL diol, the melting temperature and crystallinity of the cross-linked network also show an upward trend; the molecular weight of PCL diol has a certain influence on its fixation ability, but regardless of the length of PCL diol, the shape recovery rate of all samples can reach more than 90%. The efficient thiol-ene click chemistry reaction ensures the uniform distribution of PCL chains between cross-linked nodes, the cross-linked network has good network structure, good mechanical and shape memory properties. The exploration of new PCL cross-linked network provides a feasible way for the end functionalization of polymers.

Objective To explore the impact of venous thromboembolism (VTE) on the diagnosis and treatment of lung cancer patients. Methods We retrospectively analyzed the clinical data of lung cancer patients with VTE treated in Peking University Cancer Hospital. The incidence of VTE was calculated and the relation between VTE and lung cancer was analyzed. Results Among 1766 patients with lung cancer, VTE occurred in 115(6.5%) patients. Among 115 VTE cases, there were 78(67.8%) males patients; 82(71.3%) cases were deep venous thrombosis, 21(18.3%) cases were pulmonary embolism, 12(10.4%) cases were deep venous thrombosis with pulmonary embolism; 74(64.3%) cases were symptomatic VTE; 102(88.7%) patients received antithrombotic therapy. Among the patients who received antithrombotic therapy, 97(95.1%) cases chose drug therapy. In drug treatment, 65(67.0%) cases used adequate/standard dose. Among 115 VTE cases, 52(45.2%) patients had improvement or disappearance of thrombus, 32(27.8%) patients had no improvement, and 31(27.0%) patients with unknown results; 11(9.6%) patients had adverse reactions such as bleeding during antithrombotic therapy; 30(26.1%) patients changed antineoplastic treatment plan due to VTE. Conclusion VTE is a common complication of lung cancer patients. Antithrombotic therapy for lung cancer patients with VTE is complex, the treatment effect is not ideal and the risk of adverse reactions such as bleeding is high. VTE has a great impact on the implementation of anti-cancer treatment.

Background: Currently there is no standard therapy recommended for second‐line treatment for thymic carcinoma. Our study compared multidrug chemotherapy, single‐agent chemotherapy, and PD‐1 inhibitors in patients diagnosed with advanced thymic carcinoma who had previous platinum‐based chemotherapy at the clinic. Methods: The study included patients with thymic carcinoma who failed first‐line platinum‐based chemotherapy. Kaplan–Meier methods were applied in the study for estimating the progression‐free survival (PFS) and overall survival (OS) curves. Pearson chi‐square or Fisher's exact chi‐square test was adopted to make comparisons of the objective response rate (ORR) between treatment groups. Cox regression was used for the multivariate analyses in PFS and OS. Results: Among the 92 patients enrolled, multidrug chemotherapy was used in 51 (55.4%) patients for second‐line therapy. Thirty‐six patients (35.9%) received single‐agent chemotherapy, and eight patients (8.7%) underwent PD‐1 inhibitors. The multidrug chemotherapy group showed better efficacy than the other two groups, with an ORR of 35.3% (p = 0.006). The median PFS of multidrug chemotherapy, single‐agent chemotherapy and PD‐1 inhibitors were 5.0 months, 3.0 months, and 4.0 months, respectively (p = 0.008). Patients in the multidrug chemotherapy group also showed an advantage in OS in comparison with the other two treatment groups (p = 0.045), with a median OS of 30.4 months. Multivariate analysis showed that second‐line treatment was independent factor for both PFS (p = 0.035) and OS (p = 0.037). Grade 3–4 AEs were mostly detected in patients receiving multidrug chemotherapy and were primarily hematologic. Treatment‐related mortality was not found in any of the groups. Conclusions: Multidrug chemotherapy had a trend toward a more positive response rate and outcomes in longer survival time than single‐agent chemotherapy and PD‐1 inhibitors. Multidrug chemotherapy is a choice worth considering for second‐line therapy in patients with thymic carcinoma if tolerable. [ABSTRACT FROM AUTHOR]