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Byline: Shailesh. Khode, Raghav. Dwivedi, Peter. Rhys-Evans, Rehan. Kazi Squamous cell carcinoma involving the oral cavity (OC) and oropharynx regions are a major cause of morbidity and mortality world-wide. The [...]

Frequent heartburn sufferers are nearly 80 percent more likely to be diagnosed with throat cancer, says a study in Cancer Epidemiology, Biomarkers & Prevention. 'Regular backflow of stomach acid into [...]

Byline: Meltzer Warren, Rachel A red flag for cancer By Rachel Meltzer Warren Does your face turn merlot as soon as you imbibe? If so and you're of east Asian [...]

Byline: Greenfield, Paige Bulletin Muscle Madness Women love a hard male body, but they don't always buy into the beefcake. In a study published in Personality and Social Psychology Bulletin, [...]

BEVERLEY BALKAU, PHD [1] HENRY S. KAHN, MD [2] DOMINIQUE COURBON [1] EVELINE ESCHWEGE, MD [1] PIERRE DUCIMETIERE, PHD [1] The Paris Prospective Study OBJECTIVE -- To investigate whether insulin [...]

Background: Colorectal cancer is the third most common cancer in the world, arising mostly from pre-existing adenomatous polyps (adenomas) of the large bowel. Patients with colorectal adenomas are at increased risk of colorectal cancer because of a high recurrence rate for adenomas. We followed a cohort of 1490 patients with rectal adenomas to determine whether recurrence might be related to pathologic characteristics of the initial adenomas. Methods: The patients were identified in Haining County, China, from 1977 through 1978 by means of examination with a 15-cm rigid sigmoidoscope. They were followed by endoscopic examination at years 2, 4, 6, 11, and 16 after their initial polypectomy. New adenomas in the rectum were identified in 280 patients in these follow-up examinations. Results: Statistically significant twofold to threefold elevated risks of metachronous (recurrent) adenomas were observed for patients who had more than two initial adenomas or whose most advanced initial adenoma was more than 1.0 cm in size, was of villous/tubulovillous type, or showed moderate to severe dysplasia. Much stronger associations were observed for advanced metachronous neoplasms, which are defined as cancers or adenomas with severe dysplasia, with multivariate adjusted relative risks (95% confidence interval) of 4.2 (1.8-9.9) for a large initial adenoma ([is greater than] 1.0 cm), 8.1 (4.2-15.6) for villous/tubulovillous architecture, and 14.4 (5.0-41.3) for severe dysplasia. In particular, patients who had a large ([is greater than] 1.0 cm) adenoma with severe dysplasia at baseline had a relative risk of 37 (7.8-174.7) of developing advanced metachronous neoplasms compared with patients who had small adenoma(s) with mild dysplasia. Conclusions: The risk of metachronous adenomas is closely related to the pathology of initial adenomas, thus allowing identification of a high-risk group of adenoma patients for close surveillance after their initial polypectomy. [J Natl Cancer Inst 1998;90:1661-5]