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1. Calcifications discales intervertébrales chez l'enfant: à propos de deux cas

Author

Eitel Igor Kouamo, Merouane Nour, Jean Marie Gennar, Jean Marc Guillaume, Elie Choufani, Thierry Merrot, Jean Pierre Alessandrni, Kathia Chaumoitre, Michel Panuel, Namane Doumbouya, and Patrice Guemaleu

Subjects
herniated intervertebral calcifications, child, torticollis, Medicine
Abstract

Les calcifications discales sont le plus souvent révélées chez l'enfant, par des crises douloureuses rachidiennes. Leur localisation cervicale, semble être la plus fréquente. Cependant, les autres localisations sont moins symptomatiques et pourraient ainsi passer inaperçues. Nous rapportons deux observations d'enfants hospitalisés pour des calcifications discales cervicales symptomatiques. Il s'agit : du cas d'une fillette âgée de quatre ans et demi ayant présenté un torticolis, révélateur de la migration d'une calcification discale jusque-là asymptomatique ; et de celui du garçon âgé de 05 ans venu pour cervicalgie aiguë et chez qui une calcification discale a été retrouvée. Leur traitement était essentiellement conservateur. Les calcifications discales intervertébrales de l'enfant sont une pathologie rare dont l'étiopathogénie reste inconnue. Leur diagnostic ne doit pas se faire sans un examen neurologique attentif et une imagerie devant des douleurs rachidiennes inexpliquées chez l'enfant.

Published
2016
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2. Circumcision and Risk of Febrile Urinary Tract Infection in Boys with Posterior Urethral Valves: Result of the CIRCUP Randomized Trial

Author

Frédérique Sauvat, Alexis Arnaud, L. Fourcade, Luke Harper, Sarah Garnier, V. Flaum, Y. Chaussy, F. Collin, Cyril Ferdynus, Thomas Blanc, Thierry Merrot, J.L. Michel, Matthieu Peycelon, Marc-David Leclair, Eric Dobremez, O. Dunand, Alice Faure, M.L. Poli-Merol, and L. Huiart

Subjects
Male, medicine.medical_specialty, Urinalysis, Urology, Lower risk, law.invention, Suprapubic aspiration, Randomized controlled trial, law, Internal medicine, Humans, Medicine, Antibiotic prophylaxis, Child, Proportional Hazards Models, medicine.diagnostic_test, business.industry, Hazard ratio, Infant, Newborn, Antibiotic Prophylaxis, Pediatric urology, Pyuria, Circumcision, Male, Urinary Tract Infections, Female, medicine.symptom, Urinary Catheterization, business
Abstract

Background Boys with posterior urethral valves (PUVs) have an increased risk of febrile urinary tract infections (fUTIs). Circumcision is believed to reduce the risk of fUTIs in boys, although there are no randomized trials demonstrating this. Objective To determine the effect of circumcision on the risk of fUTIs in boys with PUVs. Design, setting, and participants A clinical randomized trial that ran between August 2012 and July 2017 was conducted. The trial was multicentric, including 13 referral centers for pediatric urology. Male boys, aged 1–28 d, diagnosed with posterior urethral valves, confirmed by voiding cystogram, were included. The exclusion criteria included presence of a genital malformation contraindicating performing a circumcision. Intervention Participants were randomized to neonatal circumcision + antibiotic prophylaxis (CATB) or antibiotic prophylaxis alone (ATB), and followed for 2 yr. Outcome measurements and statistical analysis The primary outcome was a risk of presenting fUTIs in each group. An fUTI was defined as fever (>38.5 °C) with evidence of pyuria and culture-proven infection on urinalysis, obtained by urethral catheterization or suprapubic aspiration. A bivariate analysis of the primary outcome was performed using the Kaplan-Meier method. Results and limitations In total, 91 patients were included: 49 in group CATB and 42 in group ATB. The probability of presenting an fUTI was 20% in group ATB versus 3% in group CATB. The hazard ratio of presenting an fUTI within 2 yr in the ATB group compared with that in the CATB group was 10.3 (95% confidence interval: 1.3–82.5). Sixty-four children (70.3%) had a complete follow-up at 2 yr of age. Conclusions Circumcision significantly decreases the risk of presenting an fUTI in boys with PUVs. Patient summary In this report, we compared, in a multicentric trial, the number of febrile urinary tract infections (UTIs) in boys with posterior urethral valves who had either antibiotic prophylaxis alone or antibiotic prophylaxis and circumcision. We found that those who had a circumcision had a significantly lower risk of febrile UTIs.

Published
2022
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3. Resection of Bronchogenic Cysts in Symptomatic Versus Asymptomatic Patients: An Outcome Analysis

Author

François Becmeur, Pascal Thomas, L. Fievet, Thierry Merrot, Dominique Gossot, Charline Calabre, Madalina Grigoroiu, and Henri de Lesquen

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Adolescent, Outcome analysis, Asymptomatic, Resection, Bronchogenic Cyst, Young Adult, Postoperative Complications, medicine, Humans, Cyst, Symptom onset, Child, Intraoperative Complications, Aged, Retrospective Studies, business.industry, Infant, Retrospective cohort study, Middle Aged, medicine.disease, Optimal management, Surgery, Treatment Outcome, Child, Preschool, Asymptomatic Diseases, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Mediastinal Cyst
Abstract

The natural evolution of bronchogenic cysts (BCs) is unpredictable. Although most surgeons agree that symptomatic BCs should be resected, questions remain regarding the optimal management of asymptomatic mediastinal cysts. We present a case series of BCs to compare patients who underwent preventive operation with those who underwent surgical procedure after symptom onset.This 15-year multicenter retrospective study included 114 patients (32 children and 82 adults). Data on clinical history, pathology, mean hospital stay, intraoperative and postoperative complications, and associated intraoperative procedures were analyzed separately for symptomatic and asymptomatic patients.A total of 53 asymptomatic patients (46.5%) were compared with 61 symptomatic patients (53.5%). There were significantly more adults in the symptomatic group than in the asymptomatic group (48 vs 34 patients, P.05). A thoracoscopic approach was used in 88 patients (77%), with 7 conversions to thoracotomy (9%), all in symptomatic patients. There were significantly more additional procedures (20% vs 4%, P = .01) and more intraoperative complications (20% vs 4%, P = .01) in symptomatic patients, but postoperative complications between symptomatic and asymptomatic patients were similar. The postoperative length of stay was significantly longer in symptomatic patients (5.71 days vs 4 days, P.001). Pathologic examination found significantly more inflammatory reactions in symptomatic patients.Early surgical management of BCs may be recommended to prevent symptomatic complications, which are unpredictable and whose management is more complicated in advanced BCs. Surgery can be performed with a thoracoscopic approach, which is easier and safer when the cyst is small and uncomplicated.

Published
2019

4. MP64-17 INCIDENCE OF FEBRILE URINARY TRACT INFECTION IN CHILDREN WITH HIRSCHSPRUNG DISEASE IS INCREASED IN THE FIRST MONTHS OF LIFE

Author

Claude Borrione, D. Forgues, Thierry Merrot, C. Lopez, Nicolas Kalfa, H. Allal, Faten Letaief, Benoit Tessier, Jean-Michel Guys, Anne Dariel, Olivier Maillet, Sarah Garnier, and M. P. Guibal

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Febrile urinary tract infection, Urology, Incidence (epidemiology), Medicine, Disease, business
Published
2019
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5. Neurostimulation-Guided Anal Intrasphincteric Botulinum Toxin Injection in Children with Hirschsprungʼs Disease

Author

Geraldine Hery, Alice Faure, Claude Louis-Borrione, Anne Dariel, Sarah Garnier, Jean-Michel Guys, Thierry Merrot, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital de la Timone [CHU - APHM] (TIMONE), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), and Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM]

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Anal Canal, Botulinum toxin injection, Disease, Injections, Intralesional, Gastroenterology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, 030225 pediatrics, Internal medicine, Medicine, Fecal continence, Humans, Hirschsprung Disease, Botulinum Toxins, Type A, Child, Neurostimulation, Enterocolitis, business.industry, Infant, Botulinum toxin, 3. Good health, Treatment Outcome, Child, Preschool, Pediatrics, Perinatology and Child Health, Curative surgery, 030211 gastroenterology & hepatology, Female, medicine.symptom, business, Intestinal Obstruction, medicine.drug, Cohort study
Abstract

OBJECTIVES In Hirschsprung disease (HD), despite successful surgical treatment, 50% of children experience long-term functional gastrointestinal problems, particularly chronic functional obstructive symptoms. We report our experience regarding clinical effects of neurostimulation-guided anal intrasphincteric botulinum toxin (BT) injections on postoperative obstructive symptoms attributed to a nonrelaxing anal sphincter complex in HD patients. METHODS In this monocenter cohort study, 15 HD patients with postoperative functional intestinal obstructive symptoms received neurostimulation-guided anal intrasphincteric BT injections. Short-, medium-, and long-term effects were evaluated. The Bristol stool form scale was used to assess stool consistency, and the Jorge-Wexner (JW) score to assess fecal continence. RESULTS The median age at first injection was 4 years. In the short-term, a significant improvement in stool consistency was noted in 12 of 14 patients (P = 0.0001) and JW score decreased for 14 of 15 patients (P = 0.001). In the medium-term, JW score significantly decreased for all patients (P = 0.0001), with an improvement of 50% or more for 10 patients (66.7%). In the long term, 83.3% of patients had normal stool consistency and JW score was

Published
2019
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6. Merkel Cells Sense Cooling with TRPM8 Channels

Author

Virginie Penalba, Jean-Marc Aimonetti, Nancy Osorio, Yann Roudaut, Laurent Misery, Marcel Crest, Thierry Merrot, Edith Ribot-Ciscar, Nicolas Lebonvallet, Patrick Delmas, Christelle Le Gall-Ianotto, Valentine Bouvier, Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie intégrative et adaptative (NIA), Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Neurosciences sensorielles et cognitives (NSC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), UMR 6578 : Anthropologie Bio-Culturelle (UAABC), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neurosciences de Brest (LNB), Université de Brest (UBO), Laboratoire d'Anatomie Pathologique, Hôpital Morvan Brest-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire de neurophysiologie cellulaire (LNPC), Aimonetti, Jean-Marc, Laboratoire sur les interactions Epithéliums Neurones (LIEN), and Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)

Subjects
0301 basic medicine, Keratinocytes, TRPV3, [SDV]Life Sciences [q-bio], TRPV1, TRPM Cation Channels, Dermatology, Biochemistry, Merkel Cells, 03 medical and health sciences, Transient receptor potential channel, Mice, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], medicine, TRPM8, Animals, Humans, RNA, Messenger, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Receptor, Molecular Biology, Ion channel, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, Mice, Knockout, integumentary system, Chemistry, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Cell Biology, Mechanoreceptor, Cold Temperature, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Models, Animal, Biophysics, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Merkel cell, Mechanoreceptors, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract

International audience; In the skin, Merkel cells connect with keratinocytes and Ab nerve fibers to form a touch receptor that functions as a slow adapting mechanoreceptor (slow adapting type 1). In human and mouse Merkel cells, we observed an increased concentration of intracellular Ca 2þ ions in response to cold temperature and transient receptor potential melastatine 8 (TRPM8) ion channel agonists. A reduction in the response to cooling and TRPM8 ag-onists occurred after the addition of TRPM8 antagonists, as well as in TRPM8 knockout mice. Cold temperature and TRPM8 agonists also induced a current that was inhibited by a TRPM8 antagonist. Our results indicate that Merkel cells sense cooling through TRPM8 channels. We hypothesized that cooling modulates the slow adapting type 1 receptor response. Cooling mouse skin to 22 C reduced the slow adapting type 1 receptor discharge frequency. Interestingly, we observed no such reduction in TRPM8 knockout mice. Similarly, in human skin, a temperature of 22 C applied to the slow adapting type 1 receptive field reduced the spiking discharge. Altogether, our results indicate that Merkel cells are polymodal sensory cells that respond to mild cold stimuli through the activation of TRPM8 channels. Thermal activation of Merkel cells, and possibly other TRPM8-expressing non-neuronal cells, such as keratinocytes, potentially adapts the discharge of slow adapting type 1 receptors during cooling.

Published
2018
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7. Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?

Author

Laurent Michaud, Véronique Houfflin-Debarge, Carole Langlois, Frederic Lavrand, Thierry Merrot, F Elbaz, Olivier Jaby, Guillaume Podevin, Philline de Vries, P. Delagausie, Cécile Pelatan, Frédéric Auber, Dominique Weil, Marie Laurence Polimerol, Emmanuel Sapin, Didier Aubert, Francis Becmeur, J. Gaudin, Frédéric Gottrand, Myriam Pouzac, Jean Louis Lemelle, Jean Breaud, A. Echaieb, Charles Garabedian, Rony Sfeir, Thomas Gelas, Thierry Petit, Virginie Fouquet, P. Buisson, Arnaud Bonnard, Corinne Borderon, Hubert Lardy, Naziha Khen-Dunlop, Christian Piolat, Anne Breton, Jean Luc Michel, Manuel Lopez, Christophe Laplace, Stéphane Geiss, H. Allal, Laurent Fourcade, Edouard Habonima, Université de Lille, Droit et Santé, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), and Université d'Angers (UA)

Subjects
Pediatrics, medicine.medical_specialty, Long gap, [SDV]Life Sciences [q-bio], Population, Prenatal diagnosis, Anastomosis, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Prenatal Diagnosis, medicine, Humans, 030212 general & internal medicine, Registries, education, Survival rate, Esophageal Atresia, education.field_of_study, 030219 obstetrics & reproductive medicine, business.industry, Mortality rate, Infant, Newborn, Obstetrics and Gynecology, Infant, medicine.disease, Newborn, Survival Analysis, Combined Modality Therapy, 3. Good health, Stenosis, Treatment Outcome, Atresia, Female, business, Follow-Up Studies
Abstract

International audience; OBJECTIVE: Our study aimed at (1) evaluating neonatal treatment and outcome of neonates with either a prenatal or a postnatal diagnosis of esophageal atresia (EA) and (2) analyzing the impact of prenatal diagnosis on outcome based on the type of EA.STUDY DESIGN: We conducted a population-based study using data from the French National Register for infants with EA born from 2008-2010. We compared prenatal, maternal, and neonatal characteristics among children with prenatal vs postnatal diagnosis and EA types I and III. We defined a composite variable of morbidity (anastomotic esophageal leaks, recurrent fistula, stenosis) and death at 1 year.RESULTS: Four hundred sixty-nine live births with EA were recorded with a prenatal diagnosis rate of 24.3%; 82.2% of EA type I were diagnosed prenatally compared with 17.9% of EA type III (P < .001). Transfer after birth was lower in case of prenatal diagnosis (25.6% vs 82.5%; P < .001). The delay between birth and first intervention did not differ significantly among groups. The defect size was longer among the prenatal diagnosis group (2.61 vs 1.48 cm; P < .001). The composite variables were higher in prenatal diagnosis subset (44% vs 27.6%; P = .003) and in EA type I than in type III (58.1% vs 28.3%; P < .001).CONCLUSION: Despite the excellent survival rate of EA, cases with antenatal detection have a higher morbidity rate related to the EA type (type I and/or long gap). Even though it does not modify neonatal treatment and the 1-year outcome, prenatal diagnosis allows antenatal parental counselling and avoids postnatal transfers.

Published
2015
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8. Results from the French National Esophageal Atresia register: one-year outcome

Author

Frédéric Gottrand, J.-L. Lemelle, Laurent Michaud, Rony Sfeir, Josephine Borgnon, J. Gaudin, Cécile Pelatan, Virginie Fouquet, Frédéric Auber, Christophe Laplace, J. Languepin, Frederic Lavrand, Jean-Luc Michel, Hubert Lardy, Thierry Petit, Guillaume Podevin, Allal Hossein, Anne Breton, P. Buisson, M.L. Poli-Merol, Arnaud Bonnard, Pascal de Lagausie, Corine Borderon, Olivier Jaby, Dominique Weil, Anis Echaieb, Manuel Lopez, Anne Schneider, F Elbaz, Myriam Pouzac, Thierry Merrot, François Becmeur, Jean Breaud, S. Geiss, François Lefebvre, Sébastien Blanc, Naziha Khen-Dunlop, Didier Aubert, Catherine Jacquier, E. Habonimana, Philine De Vries, Terres Inovia, PremUp Foundation, Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Viscérale Pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Diabétologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Hôpital Jeanne de Flandre [Lille], Inflammation: mécanismes et régulation et interactions avec la nutrition et les candidoses, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Hôpital Bicètre, Service de chirurgie pédiatrique, Hôpital Bicêtre, service de chirurgie viscérale pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de chirurgie pédiatrique [CHU Bordeaux], Hôpital des Enfants - Groupe hospitalier Pellegrin - CHU de Bordeaux, Service de chirurgie pédiatrique [CHU Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Mines Nantes (Mines Nantes), Theory, Algorithms and Systems for Constraints (TASC), Laboratoire d'Informatique de Nantes Atlantique (LINA), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Département informatique - EMN, Mines Nantes (Mines Nantes)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Service de Pédiatrie, Centre Hospitalier Universitaire de Reims (CHU Reims)-American Memorial Hospital (Reims), Université de Reims Champagne-Ardenne (URCA), UMR 6578 : Anthropologie Bio-Culturelle (UAABC), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie et Radiologie Pédiatrique, Université de la Méditerranée - Aix-Marseille 2, Laboratoire de recherche sur la gouvernance publique, territoire et communication (LARGOTEC/CECCOPOP), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), CHU Pontchaillou [Rennes], Centre Hospitalier Le Mans (CH Le Mans), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Régional Universitaire de Tours (CHRU de Tours), Service Pédiatrie, Centre Hospitalier Universitaire [Rennes], Service de chirurgie pédiatrique [CHU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire de Nice (CHU Nice), Service de Chirurgie infantile, CHU Fort de France-Hôpital Pierre Zobda Quitman, CHU Clermont-Ferrand, CHU Strasbourg, Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Union Nationale Interprofessionnelle des plantes riches en Protéines (UNIP), Service de chirurgie viscérale pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Gastro-entérologie, Hépatologie, Nutrition, Diabétologie, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital des Enfants, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Département informatique - EMN, Mines Nantes (Mines Nantes)-Mines Nantes (Mines Nantes)-Laboratoire d'Informatique de Nantes Atlantique (LINA), and Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Time Factors, Long term follow up, One-year outcome, [SDV]Life Sciences [q-bio], Pharmacology toxicology, Population, Treatment outcome, Outcome (game theory), Population-based registry, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, medicine, Humans, Genetics(clinical), Pharmacology (medical), Registries, 030212 general & internal medicine, education, Esophageal Atresia, Long-term follow-up, Genetics (clinical), Medicine(all), 2. Zero hunger, education.field_of_study, business.industry, Research, Infant, Newborn, Infant, General Medicine, medicine.disease, 3. Good health, Hospitalization, Treatment Outcome, Register (music), Population Surveillance, Atresia, Female, France, business, Population-Based Registry, Follow-Up Studies
Abstract

Background The aim of the present national prospective population-based study was to assess the early morbidity of esophageal atresia (EA). Methods All 38 multidisciplinary French centers that care for patients with EA returned a specific questionnaire about the 1-year outcome for each patient. This information was centralized, checked, and entered into a database. Results From the total population of 307 EA patients born in 2008 and 2009, data about the 1-year outcome were obtained from 301 (98%) patients, of whom 4% were lost to follow-up and 5% died. Medical complications occurred in 34% of the patients: anastomotic leaks (8%), recurrent tracheoesophageal fistula (4%), and anastomotic stenosis (22%); all of the latter group needed dilation (median, 2 dilations/patient). A new hospitalization was required for 59% of patients (2.5 hospitalizations/patient) for digestive (52%) or respiratory (48%) reasons. Twelve percent of patients required antireflux surgery at a median age of 164 days (range, 33–398 days), and 1% underwent an aortopexy for severe tracheomalacia. The weight/age Z-score was −0.8 (range, −5.5 to 3.7 months) at 12 months. Fifteen percent of patients were undernourished at 12 months of age, whereas 37% presented with respiratory symptoms and 15% had dysphagia at the last follow-up. Significant independent factors associated with medical complications were anastomotic esophageal tension (p = .0009) and presence of a gastrostomy (p = .0002); exclusive oral feeding at discharge was associated with a decreased risk of complications (p = .007). Conclusions Digestive and respiratory morbidities remain frequent during the first year of life and are associated with difficult anastomosis and lack of full oral feeding. Electronic supplementary material The online version of this article (doi:10.1186/s13023-014-0206-5) contains supplementary material, which is available to authorized users.

Published
2014
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9. Health-related quality of life and its determinants in children with a congenital diaphragmatic hernia

Author

Kathia Chaumoitre, Julie Berbis, Pascal Auquier, Sophie Hassid, Thierry Merrot, Karine Baumstarck, Pierre Le Coz, Fabrice Michel, Claude Martin, Agathe Gosselin, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), UMR 6578 : Anthropologie Bio-Culturelle (UAABC), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie et Radiologie Pédiatrique, Université de la Méditerranée - Aix-Marseille 2, Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)

Subjects
Quality of life, Adult, Male, Parents, Pediatrics, medicine.medical_specialty, Childhood leukemia, Health Status, Pharmacology toxicology, SF36, Congenital diaphragmatic hernia, Intensive Care Units, Pediatric, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, 030225 pediatrics, Intensive care, medicine, Humans, Genetics(clinical), Pharmacology (medical), Survivors, 030212 general & internal medicine, Child, Genetics (clinical), Hernia, Diaphragmatic, Medicine(all), Health related quality of life, business.industry, Research, Kidscreen-27, Neuropsychology, General Medicine, medicine.disease, humanities, 3. Good health, [SDV.ETH]Life Sciences [q-bio]/Ethics, Child, Preschool, Female, France, Hernias, Diaphragmatic, Congenital, business
Abstract

International audience; BACKGROUND: The development of new therapeutics has led to progress in the early management of congenital diaphragmatic hernia (CDH) in pediatric intensive care units (PICU). Little is known about the impact on the quality of life (QoL) of children and their family. The aim of this study was to assess the impact of CDH treated according to the most recent concepts and methods outlined above on child survivors' QoL and their parents' QoL. PATIENTS AND METHODS: This study incorporated a cross-sectional design performed in two PICU (Marseille, France). Families of CDH survivors born between 1999 and 2008 were eligible. The following data were recorded: socio-demographics, antenatal history and delivery, initial hospitalization history. Self-reported data were collected by mail, including current clinical problems of the children (13-symptom list), children's QoL (Kidscreen-27 questionnaire), and parents' QoL (Short-Form 36 questionnaire). Children's QoL score was compared with controls and QoL of survivors of childhood leukemia. Parent's QoL was compared with controls. Non-parametric statistics were employed. RESULTS: Forty-two families agreed to participate and questionnaires were completed by 32 of them. Twenty-one children had a current clinical problems related to CDH. All the QoL scores of CHD survivors were significantly lower compared with controls. The physical well-being dimension was significantly higher for CHD survivors compared with survivors of childhood leukemia. Gastro-esophageal reflux at discharge, antenatal diagnosis, length of stay in the PICU, and neuropsychological and respiratory issues significantly impacted QoL scores of children. The parents of CHD survivors had significantly poorer score in emotional role dimension compared with controls. CONCLUSION: The impact of CDH on QoL seems to be important and must be understood by clinicians who treat these children and their parents.

Published
2013
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10. Contents Vol. 19, 2004

Author

Josip Bačić, Cem Batukan, Marjorie R. Grafe, Gerhard Bernaschek, Gopalrao V.N. Velagaleti, Robert Anastasescu, Christa Repa, Thierry Merrot, Kurt Hecher, Dubravka Tišlarić, Bojana Brajenović-Milić, Kathia Chaumoitre, Thomas Bregenzer, Atıl Yüksel, George R. Saade, Miljenko Kapović, Smiljana Ristić, Marko Mimica, Jochen Walz, Eugenios Koumantakis, S. El Mouatassim, C. Ronsin, Liza Zikulnig, Agnes Huber, Regina Drahonsky, B.-Joachim Hackelöer, Voula Velissariou, Josef Deutinger, Marta Žuvić-Butorac, Boris Petrikovsky, M. Nouchy, Markus Hengstschläger, Werner Diehl, D. Cabrol, Marie-France Delisle, Y. Dumez, Oleg Petrović, Kenneth Lim, Karsten R. Held, F. Forestier, Sandra J. Austin, R. Ruano, L. Druard, Michael R. Harrison, M. Becker, Jessica M. Linhart, Christoph Mittermayer, Eleftheria Papadopoulou, James C Grimwade, M. Dommergues, Claude D'Ercole, Samuel Menahem, S. Gil, R. Douglas Wilson, Stavros Sifakis, S. Kuzio, and Michael B. Petersen

Subjects
Embryology, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2004
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11. Subject Index Vol. 19, 2004

Author

Voula Velissariou, Eugenios Koumantakis, Markus Hengstschläger, Michael B. Petersen, Marta Žuvić-Butorac, Christoph Mittermayer, Regina Drahonsky, D. Cabrol, Robert Anastasescu, Marjorie R. Grafe, Boris Petrikovsky, Miljenko Kapović, R. Ruano, M. Nouchy, Thierry Merrot, Gerhard Bernaschek, Michael R. Harrison, Marie-France Delisle, Jochen Walz, Cem Batukan, Liza Zikulnig, Josip Bačić, Bojana Brajenović-Milić, Kurt Hecher, Dubravka Tišlarić, Christa Repa, Oleg Petrović, M. Becker, L. Druard, Thomas Bregenzer, Atıl Yüksel, B.-Joachim Hackelöer, Stavros Sifakis, W. Diehl, Jessica M. Linhart, S. El Mouatassim, Kathia Chaumoitre, Samuel Menahem, Smiljana Ristić, S. Kuzio, C. Ronsin, Eleftheria Papadopoulou, S. Gil, M. Dommergues, Kenneth Lim, R. Douglas Wilson, Y. Dumez, Josef Deutinger, Karsten R. Held, F. Forestier, Agnes Huber, Claude D'Ercole, James C Grimwade, George R. Saade, Marko Mimica, Gopalrao V.N. Velagaleti, and Sandra J. Austin

Subjects
Embryology, Index (economics), business.industry, Pediatrics, Perinatology and Child Health, Statistics, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, Subject (documents), General Medicine, business
Published
2004
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12. The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

Author

Buffin-Meyer, Bénédicte, Klein, Julie, van der Zanden, Loes F M, Levtchenko, Elena, Moulos, Panogiotis, Lounis, Nadia, Conte-Auriol, Françoise, Hindryckx, An, Wühl, Elke, Persico, Nicola, Oepkes, Dick, Schreuder, Michiel F, Tkaczyk, Marcin, Ariceta, Gema, Fossum, Magdalena, Parvex, Paloma, Feitz, Wout, Olsen, Henning, Montini, Giovanni, Decramer, Stéphane, Schanstra, Joost P, De Catte, Luc, Vayssieres, Christophe, Sartor, Agnès, Groussolles, Marion, Plard, Christelle, Guerby, Paul, Connan, Laure, Morin, Mathieu, Simon, Elizabeth, Breaud, Jean, Saliou, Anne-Hélène, De Parscau, Loic, Jay, Nadine, Germouty, Isabelle, Le Bouar, Gwenaelle, Ryckewaert, Amelie, Manca-Pellissier, Marie-Christine, Merrot, Thierry, Laurichesse, Helene, Gallot, Denis, Bessenay, Lucie, Bidat, Laurent, Boize, Philippe, Winer, Norbert, Allain-Launey, Emma, Le Vaillant, Claudine, Prieur, Fabienne, Lavocat, Marie-Pierre, Coatleven, Frederic, Debromez, Eric, Harembat, Jérôme, Llanas, Brigitte, Favre, Romain, Moog, Raphael, Zaloszyc, Ariane, Massardier, Jérôme, Demede, Delphine, Perrotin, Franck, Cloarec, Sylvie, Vequeau-Goua, Valérie, Descombes, Emmanuelle, Boulot, Pierre, Morin, Denis, Fuchs, Florent, Tenenbaum, Julie, Ville, Yves, Blanc, Thomas, Heidet, Laurence, Paris, Anne, Dobremez, Eric, Froute, Marie-Françoise, Gondry, Jean, Muszynski, Charles, Haraux, Elodie, Lobelle, Fabienne, Chevreau, Julien, Rosenblatt, Jonathan, Baudoin, Véronique, Deschenes, Georges, Guigue, Virginie, Amblard, Florence, Bourdat-Michel, Guylhène, Schaefer, Franz, Elsässer, Michael, Rossi, Federica, Manzoni, Gianantonio, De Marco, Erika A, Capone, Valentina, Caforio, Leonardo, Zaccara, Antonio, Innocenzi, Michele, Bagolan, Pietro, Capozza, Nicola, Castagnetti, Marco, Mancini, Mariangela, van Scheltema, Phebe Adama, Kortmann, Barbara, Schreuder, Michiel, Stańczyk, Małgorzata, Szaflik, Krzysztof, Wojtera, Justyna, Krzeszowski, Waldemar, Talar, Tomasz, Pawłowska, Barbara, Fortecka-Piestrzeniewicz, Katarzyna, Olejniczak, Dariusz, Arevalo, Silvia, Rodo, Carlota, Lindgren, Peter, Chehade, Hassib, ANTENATAL Consortium, Hindryckx, A., De Catte, L., Vayssieres, C., Sartor, A., Groussolles, M., Plard, C., Guerby, P., Connan, L., Morin, M., Simon, E., Breaud, J., Saliou, A.H., De Parscau, L., Jay, N., Germouty, I., Le Bouar, G., Ryckewaert, A., Manca-Pellissier, M.C., Merrot, T., Laurichesse, H., Gallot, D., Bessenay, L., Bidat, L., Boize, P., Winer, N., Allain-Launey, E., Le Vaillant, C., Prieur, F., Lavocat, M.P., Coatleven, F., Debromez, E., Harembat, J., Llanas, B., Favre, R., Moog, R., Zaloszyc, A., Massardier, J., Demede, D., Perrotin, F., Cloarec, S., Vequeau-Goua, V., Descombes, E., Boulot, P., Morin, D., Fuchs, F., Tenenbaum, J., Ville, Y., Blanc, T., Heidet, L., Paris, A., Dobremez, E., Froute, M.F., Gondry, J., Muszynski, C., Haraux, E., Lobelle, F., Chevreau, J., Rosenblatt, J., Baudoin, V., Deschenes, G., Guigue, V., Amblard, F., Bourdat-Michel, G., Wühl, E., Schaefer, F., Elsässer, M., Persico, N., Rossi, F., Manzoni, G., De Marco, E.A., Montini, G., Capone, V., Caforio, L., Zaccara, A., Innocenzi, M., Bagolan, P., Capozza, N., Castagnetti, M., Mancini, M., Oepkes, D., van Scheltema, P.A., Feitz, W., Kortmann, B., Schreuder, M., Tkaczyk, M., Stańczyk, M., Szaflik, K., Wojtera, J., Krzeszowski, W., Talar, T., Pawłowska, B., Fortecka-Piestrzeniewicz, K., Olejniczak, D., Ariceta, G., Arevalo, S., Rodo, C., Fossum, M., Lindgren, P., Parvex, P., Chehade, H., Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Radboud University Medical Center [Nijmegen], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), HybridStat Predictive Analytics [Athens, Greece], Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospitals Leuven [Leuven], Heidelberg University Hospital [Heidelberg], University of Milan, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico [Milan, Italy], Leiden University Medical Center (LUMC), Radboud Institute for Molecular Life Sciences [Nijmegen, the Netherlands], Polish Mother’s Memorial Hospital Research Institute [Lodz] (ICZMP), Pediatric Nephrology [Barcelona, Spain] (Vall d’Hebron Hospital), Universitat Autònoma de Barcelona (UAB)-Vall d'Hebron University Hospital [Barcelona], Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Geneva University Hospital (HUG), Aarhus University Hospital, Aarhus University [Aarhus], Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, ANTENATAL Consortium: An Hindryckx, Luc De Catte, Christophe Vayssieres, Agnès Sartor, Marion Groussolles, Christelle Plard, Paul Guerby, Laure Connan, Mathieu Morin, Elizabeth Simon, Jean Breaud, Anne-Hélène Saliou, Loic De Parscau, Nadine Jay, Isabelle Germouty, Gwenaelle Le Bouar, Amelie Ryckewaert, Marie-Christine Manca-Pellissier, Thierry Merrot, Helene Laurichesse, Denis Gallot, Lucie Bessenay, Laurent Bidat, Philippe Boize, Norbert Winer, Emma Allain-Launey, Claudine Le Vaillant, Fabienne Prieur, Marie-Pierre Lavocat, Frederic Coatleven, Eric Debromez, Jérôme Harembat, Brigitte Llanas, Romain Favre, Raphael Moog, Ariane Zaloszyc, Jérôme Massardier, Delphine Demede, Franck Perrotin, Sylvie Cloarec, Valérie Vequeau-Goua, Emmanuelle Descombes, Pierre Boulot, Denis Morin, Florent Fuchs, Julie Tenenbaum, Yves Ville, Thomas Blanc, Laurence Heidet, Anne Paris, Eric Dobremez, Marie-Françoise Froute, Jean Gondry, Charles Muszynski, Elodie Haraux, Fabienne Lobelle, Julien Chevreau, Jonathan Rosenblatt, Véronique Baudoin, Georges Deschenes, Virginie Guigue, Florence Amblard, Guylhène Bourdat-Michel, Elke Wühl, Franz Schaefer, Michael Elsässer, Nicola Persico, Federica Rossi, Gianantonio Manzoni, Erika A De Marco, Giovanni Montini, Valentina Capone, Leonardo Caforio, Antonio Zaccara, Michele Innocenzi, Pietro Bagolan, Nicola Capozza, Marco Castagnetti, Mariangela Mancini, Dick Oepkes, Phebe Adama van Scheltema, Wout Feitz, Barbara Kortmann, Michiel Schreuder, Marcin Tkaczyk, Małgorzata Stańczyk, Krzysztof Szaflik, Justyna Wojtera, Waldemar Krzeszowski, Tomasz Talar, Barbara Pawłowska, Katarzyna Fortecka-Piestrzeniewicz, Dariusz Olejniczak, Gema Ariceta, Silvia Arevalo, Carlota Rodo, Magdalena Fossum, Peter Lindgren, Paloma Parvex, Hassib Chehade., Schanstra, Joost, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Università degli Studi di Milano = University of Milan (UNIMI)

Subjects
Posterior urethral valve, medicine.medical_specialty, Urinary system, [SDV]Life Sciences [q-bio], kidney disease, prenatal biomarkers, Renal function, Prenatal care, 030204 cardiovascular system & hematology, DIAGNOSIS, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Medicine, obstructive uropathy, Obstructive uropathy, development, 030304 developmental biology, RISK, 0303 health sciences, Transplantation, Kidney, ddc:618, Science & Technology, business.industry, Obstetrics, Original Articles, prediction, Urology & Nephrology, Omics, medicine.disease, 6. Clean water, 3. Good health, [SDV] Life Sciences [q-bio], Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], medicine.anatomical_structure, Nephrology, embryonic structures, Settore MED/20, URINARY-TRACT OBSTRUCTION, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business, Life Sciences & Biomedicine, Kidney disease
Abstract

Altres ajuts: The study is partially made possible by support of the 'Programme Hospitalier de Recherche Clinique and 'La Foundation de la Recherche Médicale (grant number DEQ20170336759, France). M.T. was supported by the Polish Mothers Memorial Hospital Research Institute (internal grant number 2016/IV/54-GW. LvdZ is supported by a Kolff grant from the Dutch Kidney Foundation (13OKJ36) and a ZonMW-VENI grant from the Netherlands Organisation for Scientific Research (91618036). This project has been supported by ERN ERKNet and ERN eUROGEN, which are partly co-funded by the European Union within the framework of the Third Health Programme 'ERN-2016-Framework Partnership Agreement 2017-2021'. Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1-β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV.

Published
2020
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