1. Amount of ascites impacts survival in patients with hepatocellular carcinoma undergoing transarterial chemoembolization advocating for volumetric assessment
- Author
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Lukas Müller, Daniel Bender, Simon J. Gairing, Friedrich Foerster, Arndt Weinmann, Jens Mittler, Fabian Stoehr, Moritz C. Halfmann, Aline Mähringer-Kunz, Peter R. Galle, Roman Kloeckner, and Felix Hahn
- Subjects
Hepatocellular carcinoma ,Prognosis ,Therapeutic chemoembolization ,Portal hypertension ,Ascites ,Medicine ,Science - Abstract
Abstract Preliminary work has shown that portal hypertension plays a key role for the prognosis in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). Specifically, the presence of ascites appears to be a strong negative predictor for these patients. However, it remains unclear whether different ascites volumes influence prognosis. Therefore, the aim of this work was to investigate the influence of different ascites volumes on survival for patients with HCC undergoing TACE. A total of 327 treatment-naïve patients with HCC undergoing initial TACE at our tertiary care center between 2010 and 2020 were included. In patients with ascites, the fluid was segmented, and the volume quantified by slice-wise addition using contrast-enhanced CT imaging. Median overall survival (OS) was calculated and univariate and multivariate Cox regression analysis has been performed. Ascites was present in 102 (31.9%) patients. Ascites volume as continuous variable was significantly associated with an increased hazard ratio in univariate analysis (p
- Published
- 2024
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