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1. Superfast Synthesis of Stabilized Silver Nanoparticles Using Aqueous Allium sativum (Garlic) Extract and Isoniazid Hydrazide Conjugates: Molecular Docking and In-Vitro Characterizations

Author

Jamal Moideen Muthu Mohamed, Ali Alqahtani, Thankakan Vimala Ajay Kumar, Adel Al Fatease, Taha Alqahtani, Venkatesan Krishnaraju, Fazil Ahmad, Farid Menaa, Ali Alamri, Ranjini Muthumani, and Rajendran Vijaya

Subjects
green synthesis, nanoconjugates, silver nanoparticles, isoniazid hydrazide, garlic extract, molecular docking, Organic chemistry, QD241-441
Abstract

Green synthesis of silver nanoparticles (AgNPs) was synthesized from fresh garlic extract coupled with isoniazid hydrazide (INH), a commonly used antibiotic to treat tuberculosis. A molecular docking study conducted with the selected compounds compared with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis. The aqueous extract of garlic was prepared and mixed with silver nitrate (AgNO3) solution for the superfast synthesis of stable AgNPs. INH was then conjugated with AgNPs at different ratios (v/v) to obtain stable INH-AgNPs conjugates (AgNCs). The resulting AgNCs characterized by FTIR spectra revealed the ultrafast formation of AgNPs (

Published
2021
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