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BACKGROUND AND AIMS Anemia is a highly prevalent and modifiable comorbidity in patients with chronic kidney disease (CKD), which tends to aggravate as the disease progresses. The economic burden of anemia in CKD is high, and quality of life issues (e.g. fatigue, reduced productivity) is common in these patients. Data on the prevalence and treatment of anemia in CKD stages 3 and 4 (based on the estimated glomerular filtration rate according to KDIGO classification) in Portugal are lacking. The NEFROPOR study aimed to estimate the prevalence of anemia in patients with CKD stage 3 or 4 admitted to a Nephrology consultation between 1 January and 31 March 2017 and characterize anemia treatment in this patient population. METHODS NEFROPOR was a retrospective, multicentric study carried out in 10 Portuguese centers. All patients aged ≥18 years with stage 3 or 4 CKD admitted to a Nephrology consultation in one of those centers between 1 January and 31 March 2017 were invited to participate, and data for up to 24 months after admission were collected from patients’ clinical files. Retrieved data included age, body mass index (BMI), anemia status according to the World Health Organization (WHO) diagnostic criteria, and anemia treatment type and duration. Three assessments of the prevalence anemia were performed: at the time of the first Nephrology visit (presentation), at the first analytical results and the overall prevalence in the study cohort. Statistical analysis was performed in SPSS Statistics (v26) and a 0.05 significance level was adopted. RESULTS A total of 176 patients were included in this study, mostly (61.9%) male, with a median age of 76 years (range, 26–97) and a mean BMI indicative of pre-obesity (28.2; standard deviation, 4.2). CKD stage 3b was predominant (43.2%), followed by stage 4 (32.4%) and stage 3a (24.4%). The most frequent CKD etiologies in this cohort were diabetes (39.8%), followed by arterial hypertension (27.8%) and unknown cause (25.6%). Arterial hypertension was largely the most frequent comorbidity, present in 90.3% of patients, followed by diabetes (54.0%). Although less prevalent, coronary artery disease (18.2%) and congestive heart failure (14.8%) were also identified in this patient population. A total of 44.9% of patients [95% confidence interval (CI), 37.7%–52.3%] had anemia at presentation, which was significantly associated with CKD stage, diabetes, peripheral vascular disease and myocardial infarction comorbidities, and diabetes and unknown CKD etiology. The overall prevalence of anemia in the study cohort was 61.9% (95% CI 54.6%–68.9%), and it was significantly associated with diabetes and peripheral vascular disease comorbidities and with diabetes and primary glomerulonephritis as CKD etiologies. The prevalence of anemia at the first analytical results was 49.4% (95% CI 42.1%–56.8%), and it was significantly associated with CKD stage, diabetes, non-skin cancer, peripheral vascular disease and myocardial infarction comorbidities, and diabetes as CKD etiology. Figure 1 shows the evolution of anemia treatment in this cohort over 24 + months. CONCLUSION The three estimates of the prevalence of anemia in this study were consistent with each other, particularly those for the first visit and first analytical results. The latter were also consistent with evidence in the literature reporting a prevalence of anemia in the population of patients with CKD stages 3 and 4 between 40% and 60%. The overall prevalence of anemia in this study was 12%–15% higher than first visit and first analytical results estimates, in agreement with the fact that this refers to a cumulative prevalence. These data support the need for optimized and individualized treatment strategies for patients with CKD stages 3 and 4, maximizing the efficiency of health-care resource use.

Alagille syndrome (AGLS) is a rare genetic disorder caused by mutations in the Notch signaling pathway. Multiple organ dysfunction is frequent despite phenotypic variability. We report the case of an AGLS patient with right heart failure and persistent fluid overload who started peritoneal ultrafiltration, without initial benefit. Possible pathophysiological mechanisms related to the underlying genetic condition, namely vascular abnormalities, that could help explain the poor ultrafiltration are provided, while other ultrafiltration failure causes are briefly discussed. New evidence is necessary for a better understanding of this syndrome in PD modality.

Submitted by Ana Quininha (ana.quininha@chlc.min-saude.pt) on 2021-11-23T15:22:33Z No. of bitstreams: 1 Port J Nephrol 2021 207.pdf: 932318 bytes, checksum: af62f7f3515551789b85253e72229842 (MD5) Made available in DSpace on 2021-11-23T15:22:33Z (GMT). No. of bitstreams: 1 Port J Nephrol 2021 207.pdf: 932318 bytes, checksum: af62f7f3515551789b85253e72229842 (MD5) Previous issue date: 2021 info:eu-repo/semantics/publishedVersion

Patients requiring renal replacement therapy remain a significant burden on the healthcare system. A substantial amount of hospitalization costs for these patients are related to vascular complications, especially catheter-related thrombosis, which is associated with a significant increase in morbidity and mortality. We report the case of a male patient with multiple myeloma (MM) and dialysis-dependent renal failure due to light-chain cast nephropathy, who presented recurrent early catheter dysfunction. A large thrombus was detected, extending from the superior vena cava (SVC) to the right atrium (RA) and later at the inferior vena cava (IVC), ultimately leading to exhaustion of vascular capital. To this date, there is limited evidence regarding the best approach to catheter-related thrombosis, which frequently leads to treatment dilemmas in clinical practice and demands careful evaluation and individualized decisions. In patients with a highly thrombotic profile, peritoneal dialysis may be considered earlier to prevent further vascular capital damage.

Background and Aims The incident patients on hemodialysis (HD) are becoming older. However, the optimal type of initial permanent vascular access (VA) among the elderly is controversial. Patient comorbidities and life expectancy are important considerations in whether to place an arteriovenous fistula (AVF) or graft (AVG). We design an observational study to compare clinical outcomes of elderly (≥65 year old) versus younger patients, who underwent for first VA placement before initiation of renal replacement therapy, between January 2014 and December 2018. Method We evaluated successful use of VA, requirement of surgical interventions before successful use, VA in use after the first and third months on HD and clinical outcomes, until December 2019. The comorbidity burden was calculated through age-adjusted Charlson Comorbidity Index (aCCI). We also evaluated the impact of comorbidity burden on the VA type on HD start and mortality after HD initiation. Results We identified 252 predialysis patients who underwent for VA placement in our center. We created two groups based on age at the time of VA placement: there were 199 (79,0%) with age ≥ 65 years (the elderly group), and 53 (21,0%) younger patients. The elderly group presented a mean age of 76,3 ± 6,4 (maximum of 92) years on first VA placement; in the younger group, the mean age was 54,5 ± 9,1 (minimum of 26) years. The following analysis are presented for elderly versus younger group. On both groups there were a predominance of male gender (66,8%; 73,6%; p=0,498) and caucasian race (95,0%; 88,7%; p=0,193). At time of referral for AV placement, both groups presented similar mean estimated glomerular filtration rate by CKD-EPI equation (11,7 ± 3,2; 11,2 ± 3,2 mL/Kg/1,72m2; p=0,391). Elderly group presented a significant higher aCCI (7,3 ± 1,74; 9,0 ± 1,9; p For all patients, the first VA placed was AVF. Only two patient placed an AVG on second and third vascular accesses. The median number of VA placed were similar between the two groups [1,0 (1 to 4); 1,0 (1 to 2); p= 0,811], likewise the occurrence of early complications (9,5%; 5,7%; p=0,583) and the need for surgical interventions (46,7%; 47,2%; p=1,000). In both groups, the majority of patients started HD (80,4%; 90,6%; p=0,103), with similar successful use of the VA (68,1%; 75,0%; p=0,474). In multivariate logistic regression, proteinuria (measured at time of referral for AV placement) and heart failure (HF) were predictors to HD initiation through a central venous catheter (CVC). This model classified correctly 74,9% of cases, with an HF odds ratio (OR) of 4,149 [confident interval (CI) of 1,721 to 10,000] and a proteinuria OR of 1,148 (CI: 1,047 to 1,259). After the first month on HD, 34,8% of elderly patients needed a CVC, a number significantly different from the younger group (15,9%; p=0,023). The same result was observed after the third month (22,2%; 7,1%; p=0,028). During the time of follow-up, the mortality rate was higher in the elderly group who started HD (log Rank test = 0,004), with a median survival of 29,3 (0,1 to 89,8) months, when compared to the younger group [median survival of 38,3 (0,1 to 76,9) months]. Conclusion There were no difference in the kind of VA on HD start (definitive VA versus CVC) between the two groups. However, elderly patients presented more fistula failure in the first three months after HD initiation. The need of CVC due to nonfunctioning AVF on the first and three months after HD initiation was higher in the elderly. The analysis of the patients who started HD showed that the elderly group presented a significant reduced survival when compared to the youngest patients.

A análise das estruturas de aprisionamento necessita de atender ao quadro institucional no qual se encontra enquadrado. A compreensão das finalidades às quais reporta apenas pode ser captada na alusão a um quadro teórico e conceptual que não se cinja à apreensão restrita das suas mais evidentes manifestações. O enredo da Angola colonial, no qual nos focamos, imprime a necessidade de nos afastarmos dos recorrentes estudos que tendem a evidenciar a brutalidade da prática repressiva no interior das prisões, menosprezando, por iminência, uma análise que capte as características longitudinais que ditam as estruturas administrativas das suas bases materiais. Assente na defesa de um alargamento conceptual das práticas de confinamento, pretende esta investigação contribuir para os estudos que atendem à necessidade destes estabelecimentos serem analisados à luz de outras instâncias, nomeadamente o trabalho forçado e o incipiente poder infraestrutural do estado colonial. De forma a alcançar tal propósito esta dissertação concebe uma análise que contrapõe às finalidades impressas nos códigos legais dos estatutos criminais coloniais os relatórios arquivísticos. Estes dão conta da prática que regia o modus operandi destes estabelecimentos e atestam a debilidade morfológica do poder estatal colonial. É face a tal que se apresenta, numa última análise, as instâncias que nos permitem pensar o enredo edificado pelas empresas concessionárias no território colonial numa relação de analogia com a prisão colonial. Tal comparação é aqui edificada pelo recurso ao estudo de caso da Companhia de Diamantes de Angola, problematizando-se o modo como esta empresa substituía o poder do estado colonial ao implementar políticas públicas de gestão e controlo das massas trabalhadoras que se encontravam sob a sua alçada.

O meu Estágio Profissional desenvolveu-se numa Instituição que tem uma orientação que lhe é peculiar, uma vez que toda a metodologia implementada se rege pelo M étodo de João de Deus, que até hoje se reconhece de inegável valor educativo, proporcionando uma formação integrada aos futuros cidadãos. Possui uma organização interna e um método que acarretam os requisitos essenciais, para uma resposta de qualidade à sociedade actual. Submitted by Sofia Falcão (sofia.falcao@escolasjoaodeus.pt) on 2012-09-26T10:22:35Z No. of bitstreams: 1 TeseTeresaCardoso.pdf: 3546339 bytes, checksum: 8a999f11b9d8ff94fc71a43eaa199dcd (MD5) Approved for entry into archive by Sofia Falcão (sofia.falcao@escolasjoaodeus.pt) on 2012-09-26T10:22:44Z (GMT) No. of bitstreams: 1 TeseTeresaCardoso.pdf: 3546339 bytes, checksum: 8a999f11b9d8ff94fc71a43eaa199dcd (MD5) Made available in DSpace on 2012-09-26T10:22:44Z (GMT). No. of bitstreams: 1 TeseTeresaCardoso.pdf: 3546339 bytes, checksum: 8a999f11b9d8ff94fc71a43eaa199dcd (MD5) Previous issue date: 2012-09