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5. Anti-specific human antibodies from mice comprising four comprising four distinct genetic modifications

Author

Lonberg, Nils, Taylor, Lisa D., Harding, Flona A., Trounstine, Mary, Higgins, Kay M., Schramm, Stephen R., Kuo, Chiung-Chi, Mashayekh, Roshanak, McCabe, James G., Munnoz-O'Regan, Donna, O'Donnell, Susan, Lapachet, Elizabeth S.G., Bengoechea, Tasha, Fishwild, Dianne M., Carmack, Condie E., Kay, Robert M., and Huszar, Dennis

Subjects
Immunoglobulins -- Physiological aspects, Immune system -- Analysis, B cells -- Differentiation, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Studies on transgenic mice that express human IgM, IgG and Igkappa reveal that human immunoglobulin-expressing B cells develop and respond normally in a mouse immune system. The antigen response causes immunoglobulin heavy-chain isotype switching and differential somatic mutations. The use of conventional hybridoma technology enables the acquisition of human sequence antibodies from these mice.

Published
1994

6. Human immunoglobulin heavy-chain minilocus recombination in transgenic mice: gene-segment use in micro and gamma transcripts

Author

Tuaillon, Nadine, Taylor, Lisa D., Lonberg, Nils, Tucker, Philip W., and Capra, J. Donald

Subjects
Immunoglobulin genes -- Research, Genetically modified mice -- Usage, Science and technology
Abstract

The analysis of the expression of a human immunoglobulin heavy-chain minilocus in transgenic mice was reported. The transgenic minilocus is expressed in mice in a manner analogous to that of the human heavy-chain complex. The repertoire was fetal in appearance with the absence of somatic mutation. It was found that the two heavy-chain variable gene segments rearranged to micro- and gamma-chain constant segments. The functional gene segment is rearranged more frequently than the pseudogene. Thus, it was shown that the functional gene segment can undergo a class-switch.

Published
1993

7. Antigen-specific human antibodies from mice comprising four distinct genetic modifications

Author

Lonberg, Nils, primary, Taylor, Lisa D., additional, Harding, Fiona A., additional, Trounstine, Mary, additional, Higgins, Kay M., additional, Schramm, Stephen R., additional, Kuo, Chiung-Chi, additional, Mashayekh, Roshanak, additional, Wymore, Kathryn, additional, McCabe, James G., additional, Munoz-O'Regan, Donna, additional, O'Donnell, Susan L., additional, Lapachet, Elizabeth S. G., additional, Bengoechea, Tasha, additional, Fishwild, Dianne M., additional, Carmack, Condie E., additional, Kay, Robert M., additional, and Huszar, Dennis, additional

Published
1994
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