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4 results on '"Taupin, Veronique"'

1. A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models

Author

Lopez-Grancha, Matilde, primary, Bernardelli, Patrick, additional, Moindrot, Nicolas, additional, Genet, Elisabeth, additional, Vincent, Carine, additional, Roudieres, Valerie, additional, Krick, AIain, additional, Sabuco, Jean-François, additional, Machnik, David, additional, Ibghi, Delphine, additional, Pradier, Laurent, additional, and Taupin, Veronique, additional

Published
2021
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2. Total synthesis of (+)-nankakurines A and B and (plusmn)-5-epi-nankakurine A

Author

Altman, Ryan A., Nilsson, Bradley L., Overman, Larry E., de Alaniz, Javier Read, Rohde, Jason M., and Taupin, Veronique

Subjects
Alkaloids -- Chemical properties, Alkaloids -- Structure, Club-mosses -- Composition, Clubmosses -- Composition, Ring formation (Chemistry) -- Analysis, Heterocyclic aromatic compounds -- Structure, Heterocyclic aromatic compounds -- Chemical properties, Quinoline -- Structure, Quinoline -- Chemical properties, Schiff bases -- Chemical properties, Biological sciences, Chemistry
Abstract

The first total syntheses of the Lycopodium alkaloids (+)-nankakurine A, (+)-nankakurine B and the originally supported structure of nankakurine A is feature a demanding intramolecular azomethine imine cycloaddition as the key step is reported. The reaction generated the octahydro-3,5-ethanoquinoline moiety and installed the correct relative configuration at the spiropiperidine ring juncture.

Published
2010

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