205 results on '"Tatsuya Ito"'
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2. Adsorption behavior of platinum-group metals and Co-existing metal ions from simulated high-level liquid waste using HONTA and Crea impregnated adsorbent
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Naoki Osawa, Seong-Yun Kim, Masahiko Kubota, Hao Wu, Sou Watanabe, Tatsuya Ito, and Ryuji Nagaishi
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Simulated high-level liquid waste ,Platinum-group metals ,Adsorption ,Separation ,Impregnated adsorbent ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
The volume and toxicity of radioactive waste can be decreased by separating the components of high-level liquid waste according to their properties. An impregnated silica-based adsorbent was prepared in this study by combining N,N,N′,N′,N″,N″-hexa-n-octylnitrilotriacetamide (HONTA) extractant, N′,N′-di-n-hexyl-thiodiglycolamide (Crea) extractant, and macroporous silica polymer composite particles (SiO2–P). The performance of platinum-group metals adsorption and separation on prepared (HONTA + Crea)/SiO2–P adsorbent was then assessed together with that of co-existing metal ions by batch-adsorption and chromatographic separation studies. From the batch-adsorption experiment results, (HONTA + Crea)/SiO2–P adsorbent showed high adsorption performance of Pd(II) owing to an affinity between Pd(II) and Crea extractant based on the Hard and Soft Acids and Bases theory. Additionally, significant adsorption performance was observed toward Zr(IV) and Mo(VI). Compared with studies using the Crea extractant, the high adsorption performance of Zr(IV) and Mo(VI) is attributed to the HONTA extractant. As revealed from the chromatographic experiment results, most of Pd(II) was recovered from the feed solution using 0.2 M thiourea in 0.1 M HNO3. Additionally, the possibility of recovery of Zr(IV), Mo(VI), and Re(VII) was observed using the (HONTA + Crea)/SiO2–P adsorbent.
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- 2024
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3. Lemierre’s Syndrome after Head and Neck Photoimmunotherapy for Local Recurrence of Nasopharyngeal Carcinoma
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Midori Nishimura, Isaku Okamoto, Tatsuya Ito, Kunihiko Tokashiki, and Kiyoaki Tsukahara
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head and neck photoimmunotherapy ,lemierre’s syndrome ,head and neck carcinoma ,nasopharyngeal carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: Head and neck photoimmunotherapy (HN-PIT) uses a combination of drugs and laser illumination to specifically destroy tumor cells. Lemierre’s syndrome is an infectious disease with severe systemic symptoms caused by prior infection in the pharyngeal region, leading to thrombophlebitis. Here, we report a case of Lemierre’s syndrome that developed after HN-PIT for recurrent nasopharyngeal carcinoma. Case Presentation: A 68-year-old male with nasopharyngeal carcinoma (squamous cell carcinoma) underwent HN-PIT after local recurrence with chemoradiation therapy. Three months after HN-PIT, the patient developed fever and neck pain, which led to a diagnosis of Lemierre’s syndrome. The patient was treated with antibiotics and anticoagulants for at least 1 month. The patient’s general condition and inflammatory findings on blood sampling showed gradual improvement, and a follow-up cervicothoracic computed tomography imaging showed that the venous thrombus had been obscured and the patient was doing well. Conclusion: HN-PIT is a high-risk procedure for the development of Lemierre’s syndrome due to irradiation-induced mucositis, and anticipating the development of Lemierre’s syndrome during HN-PIT is important.
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- 2024
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4. A high-hydrostatic pressure device for nevus tissue inactivation and dermal regeneration for reconstructing skin defects after giant congenital melanocytic nevus excision: a clinical trial
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Hiroki Yamanaka, Eiichi Sawaragi, Takashi Nakano, Yasuhiro Katayama, Tatsuya Ito, Harue Tada, Yu Hidaka, Satoshi Morita, Chihiro Funakoshi, Akemi Kinoshita, Mieko Watanabe, Itaru Tsuge, Motoki Katsube, Michiharu Sakamoto, Tetsuji Yamaoka, and Naoki Morimoto
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Giant congenital melanocytic nevi ,High-hydrostatic pressure ,Dermal regeneration ,Autologous scaffold ,Cultured epithelial autografts ,Medicine (General) ,R5-920 ,Cytology ,QH573-671 - Abstract
Background: A novel treatment has been developed to reconstruct large skin defects caused by the excision of giant congenital melanocytic nevi. It involves the reimplantation of high-hydrostatic pressurized nevus tissue as a cell-inactivated autologous scaffold for dermal regeneration, followed by the implantation of cultured epithelial autografts on the regenerated dermis. Because this treatment has shown promise in a first-in-human clinical trial which used a prototype pressure machine, a novel pressure device was specifically designed for clinical use. Methods: In a prospective investigator-initiated clinical trial involving three patients, we evaluated the safety and efficacy of the skin regeneration treatment using a pressure device. All three patients underwent surgical excision of the nevus tissue, primary reimplantation of the inactivated nevus tissue, and secondary implantation of cultured epithelial autografts. Results: Engraftment of inactivated nevus tissue and cultured epithelial autografts was successful in all three cases, with over 90% epithelialization at 8 weeks post-surgery. No serious adverse events or device malfunction were observed during the trial. Conclusion: The novel pressure device safely and effectively enabled dermal regeneration using the nevus tissue as an autologous scaffold. This innovative approach offers several advantages, including reduced invasiveness due to minimal sacrifice of normal skin for skin grafting and high curative potential resulting from full-thickness removal of the nevus tissue.
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- 2023
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5. A Case of Oropharyngeal Carcinoma with an Oblique Neck that Benefited from Transoral Robotic Surgery
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Tatsuya Yamakura, Akira Shimizu, Isaku Okamoto, Takuro Okada, Kunihiko Tokashiki, Takuma Kishida, Tatsuya Ito, and Kiyoaki Tsukahara
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transoral robotic surgery ,oropharyngeal carcinoma ,skeletal disorder ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Transoral robotic surgery (TORS) and transoral videolaryngoscopic surgery (TOVS) are minimally invasive procedures for early-stage head and neck cancers. However, due to its unique nature, transoral resection often leads to skeletal and anatomical disorders. We describe a case in which TORS was used in a 71-year-old man with a skeletal disorder, spastic stridor, and a T2N1M0 stage I p16-positive oropharyngeal carcinoma. Prior to the procedure, he underwent right cervical dissection (levels II–IV). Although he had an oblique neck, the right side of his neck was naturally hyperextended because the dissection was performed on the right side. The right facial, lingual, and external carotid arteries were ligated in preparation for TORS. Postoperative pathological examination revealed no extranodal involvement of the metastatic lymph nodes. A two-stage TOVS procedure was performed for the oropharyngeal tumor, in which the surgeon was required to be positioned at the patient’s head to allow direct manipulation. This makes the neck and oral cavity more susceptible to the skeletal effects. In contrast, in TORS, the da Vinci insertion angle can be set to match the angle of the neck, allowing surgeons to operate with less skeletal influence. TORS is more useful in this setting.
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- 2023
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6. World-first report of low anterior resection for rectal cancer with the hinotori™ Surgical Robot System: a case report
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Ryo Miura, Koichi Okuya, Emi Akizuki, Masaaki Miyo, Ai Noda, Masayuki Ishii, Momoko Ichihara, Takahiro Korai, Maho Toyota, Tatsuya Ito, Tadashi Ogawa, Akina Kimura, and Ichiro Takemasa
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Hinotori ,Rectal cancer ,Robotic surgery ,Low anterior resection ,Surgery ,RD1-811 - Abstract
Abstract Background The hinotori™ Surgical Robot System was approved for use in colorectal cancer surgery in Japan in 2022. This robot has advantages, such as an operation arm with eight axes, an adjustable arm base, and a flexible three-dimensional viewer, and is expected to be utilized in rectal cancer surgery. Herein, we report the world's first surgery for rectal cancer using the hinotori™ Surgical Robot System. Case presentation A 71-year-old woman presented to our hospital with bloody stools. A colonoscopy revealed type 2 advanced cancer in the rectum, and a histological examination exposed a well-differentiated adenocarcinoma. Abdominal enhanced computed tomography divulged rectal wall thickening without significant swelling of the lymph nodes or distant metastasis. Pelvic magnetic resonance imaging showed tumor invasion beyond the intrinsic rectal muscle layer. The patient was diagnosed with cStage IIa (cT3N0M0) rectal cancer and underwent low anterior resection using the hinotori™ Surgical Robot System. Based on an adequate simulation, surgery was safely performed with appropriate port placement and arm base-angle adjustment. The operating time was 262 min, with a cockpit time of 134 min. Subsequently, the patient was discharged 10 days postoperatively without complications. The pathological diagnosis was pStage IIA (cT3N0M0) and the circumferential resection margin was 6 mm. Conclusions We report the first case of low anterior resection for rectal cancer using the hinotori™ Surgical Robot System, in which a safe and appropriate oncological surgery was performed.
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- 2023
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7. Impact of coronary bifurcation angle on stent malapposition in a randomized comparison between proximal optimization technique followed by side branch dilatation and kissing balloon inflation
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Masahiro Yamawaki, Yoshinobu Murasato, Yusuke Watanabe, Yoshihisa Kinoshita, Munenori Okubo, Kazuhiko Yumoto, Naoki Masuda, Hiromasa Otake, Jiro Aoki, Gaku Nakazawa, Yohei Numasawa, Tatsuya Ito, Junya Shite, Takayuki Okamura, Kensuke Takagi, Kayoko Kozuma, Thierry Lefèvre, Bernard Chevalier, Yves Louvard, Nobuaki Suzuki, and Ken Kozuma
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Percutaneous coronary intervention ,Coronary bifurcation ,Optical coherence tomography ,Drug-eluting stent ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The impact of coronary bifurcation angle (BA) on incomplete stent apposition (ISA) after crossover stenting followed by side branch (SB) intervention has not been established. Methods: A total of 100 crossover stentings randomly treated with proximal optimization technique followed by short balloon dilation in the SB (POT-SBD group, 48 patients) and final kissing balloon technique (KBT group, 52 patients) were analyzed in the PROPOT trial. Major ISA with maximum distance > 400 μm and its location was determined using optical coherence tomography before SB intervention and at the final procedure. The BA was defined as the angle between the distal main vessel and SB. Optimal POT was determined when the difference in stent volume index between the proximal and distal bifurcation was greater than the median value (0.86 mm3/mm) before SB intervention. Result: Major ISA was more frequently observed in the POT-SBD than in the KBT group (35% versus 17%, p
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- 2023
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8. Pd2MnGa Metamagnetic Shape Memory Alloy with Small Energy Loss
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Tatsuya Ito, Xiao Xu, Atsushi Miyake, Yuto Kinoshita, Makoto Nagasako, Kohki Takahashi, Toshihiro Omori, Masashi Tokunaga, and Ryosuke Kainuma
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Heusler alloys ,martensitic transformation ,martensitic transformation hysteresis ,metamagnetic shape memory alloys ,Pd2MnGa alloy ,Science - Abstract
Abstract Metamagnetic shape memory alloys (MMSMAs) are attractive functional materials owing to their unique properties such as magnetostrain, magnetoresistance, and the magnetocaloric effect caused by magnetic‐field‐induced transitions. However, the energy loss during the martensitic transformation, that is, the dissipation energy, Edis, is sometimes large for these alloys, which limits their applications. In this paper, a new Pd2MnGa Heusler‐type MMSMA with an extremely small Edis and hysteresis is reported. The microstructures, crystal structures, magnetic properties, martensitic transformations, and magnetic‐field‐induced strain of aged Pd2MnGa alloys are investigated. A martensitic transformation from L21 to 10M structures is seen at 127.4 K with a small thermal hysteresis of 1.3 K. The reverse martensitic transformation is induced by applying a magnetic field with a small Edis (= 0.3 J mol−1 only) and a small magnetic‐field hysteresis (= 7 kOe) at 120 K. The low values of Edis and the hysteresis may be attributed to good lattice compatibility in the martensitic transformation. A large magnetic‐field‐induced strain of 0.26% is recorded, indicating the proposed MMSMA's potential as an actuator. The Pd2MnGa alloy with low values of Edis and hysteresis may enable new possibilities for high‐efficiency MMSMAs.
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- 2023
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9. One-pot synthesis of silica-gel-based adsorbent with Schiff base group for the recovery of palladium ions from simulated high-level liquid waste
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Hao Wu, Seong-Yun Kim, Tatsuya Ito, Misako Miwa, and Shigeo Matsuyama
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Schiff base ,Silica-gel ,Palladium ion ,Particle-induced X-ray emission analysis ,Simulated high-level liquid waste ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
A simple solvothermal reaction was used to prepare a 3-aminopropyl-functionalized silica-gel-based adsorbent for adsorbing Pd(II) from the nitric acid solution. Scanning electron microscopy, fourier transform infrared spectroscopy, and thermogravimetry analysis were performed on the as-synthesized adsorbent to demonstrate the successful introduction of Schiff base groups. Batch experiments were used to investigate the effects of contact time, nitric acid concentration, solution temperature, and adsorption capacity. It is worth noting that the prepared adsorbent exhibited a higher affinity toward Pd(II) with the uptake approximately 100% even in a 2 M HNO3 solution. At an equilibrium time of 5 h, the maximum adsorption capacity of Pd(II) was estimated to be 0.452 mmol/g. The adsorbed Pd(II) could be completely eluted by dissolving 0.2 M thiourea solution in 0.1 M HNO3. Using a combination of particle-induced X-ray emission analysis and an X-ray photoelectron spectrometer, the adsorbed Pd was found to be uniformly distributed on the surface of the prepared adsorbent and the existing species were Pd(II) and zero-valent Pd(0). Due to the desirable performances, facile preparation method, and abundant raw material source, the prepared adsorbent demonstrated a high application potential in the recovery of Pd(II) from simulated high-level liquid waste treatment.
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- 2022
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10. Impairment of Social-Related Quality of Life in COVID-19 Pneumonia Survivors: A Prospective Longitudinal Study
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Takahiro Ando, Sho Shimada, Jun Sugihara, Koji Takayama, Masayoshi Kobayashi, Yoshihiro Miyashita, Tatsuya Ito, Kaori Okayasu, Shun Tsuyuki, Takehiko Ohba, Masafumi Doi, Hiroaki Saito, Toshihide Fujie, Tomoshige Chiaki, Atsushi Nakagawa, Tatsuhiko Anzai, Kunihiko Takahashi, Sho Shibata, Tomoya Tateishi, and Yasunari Miyazaki
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COVID-19 pneumonia ,post-acute sequelae of SARS-CoV-2 infection ,respiratory sequelae ,quality of life ,SF-36 ,Medicine - Abstract
The post-acute sequelae of SARS-CoV-2 (PASC) pose a threat to patients’ health-related quality of life (HRQOL). Here, the impact of COVID-19 on HRQOL and the clinical factors associated with impaired HRQOL were examined. Discharged COVID-19 patients were assessed at 3 and 6 months after disease onset. The patients completed a medical examination and the SF-36 questionnaire at these two time points and underwent pulmonary function testing at 6 months after disease onset. All had undergone computed tomography (CT) imaging upon hospital admission. Of the 74 included patients, 38% reported respiratory symptoms at 3 months, and 26% reported respiratory symptoms at 6 months after disease onset. The aggregated SF-36 scores declined in the role/social component summary (RCS), a category related to social activity. Patients with lower RCS tended to have respiratory sequelae or a relatively lower forced vital capacity. The CT score that reflected the extent of COVID-19 pneumonia was inversely correlated with the RCS score (3 months, p = 0.0024; 6 months, p = 0.0464). A high CT score (≥10 points) predicted a low RCS score at 6 months (p = 0.013). This study highlights the impairment of RCS and its associations with respiratory sequelae. The study also emphasizes the importance of radiological findings in predicting long-term HRQOL outcomes after COVID-19.
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- 2023
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11. Laparoscopic low anterior resection for rectal cancer wherein the inferior mesenteric artery arose from the superior mesenteric artery: a case report
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Takahiro Korai, Kenji Okita, Toshihiko Nishidate, Koichi Okuya, Emi Akizuki, Yu Sato, Atsushi Hamabe, Daisuke Kyuno, Masayuki Ishii, Ryo Miura, Masafumi Imamura, Minoru Nagayama, Takeshi Murakami, Takayuki Nobuoka, Tatsuya Ito, and Ichiro Takemasa
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Rectal cancer ,Inferior mesenteric artery ,Superior mesenteric artery ,Surgery ,RD1-811 - Abstract
Abstract Background Few cases have been reported of colorectal cancer with inferior mesenteric artery (IMA) branching abnormalities; therefore, the lymphatic flow in such cases remains unknown. We report the first case of locally advanced rectal cancer in which the IMA arose from the superior mesenteric artery (SMA) in which we achieved to visualize the lymphatic flow. Case presentation A 65-year-old woman complaining of bloody stools was investigated in our hospital and suspected with rectal cancer. Colonoscopy and abdominal enhanced computed tomography (CT) revealed a circumscribed, localized ulcerative tumor in the rectum. 3-Dimensional contrast-enhanced computed tomography (3D-CT) showed that the IMA arose from the SMA. The patient was diagnosed with rectal cancer (cT3N0M0, cStage IIa) and laparoscopic low anterior resection was performed. The sigmoid colon was resected using the medial approach. Only the plexus of the colic branch of the lumbar splanchnic nerve was observed at the site where the root of the IMA usually exists and showed interruption of the indocyanine green (ICG) fluorescence-illuminated lymphatics. The root of the IMA was ligated, and Japanese D3 lymphadenectomy was performed, preserving the accessory middle colic artery. All fluorescent lymph nodes were resected. The pathological diagnosis was pT4aN1aM0 stage IIIb. The patient’s postoperative course was uneventful. Adjuvant chemotherapy was administered, and the patient was recurrence-free at 1.5 years after surgery. Conclusions We were able to perform safe and appropriate surgery oncologically, despite abnormal vascular anatomy, due to preoperative identification using 3D-CT and intraoperative navigation using ICG administration.
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- 2021
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12. Changes in carnitine levels through induction chemotherapy in head and neck cancer patients as a potential cause of therapy-related malaise
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Tatsuya Ito, Kiyoaki Tsukahara, Hiroki Sato, Akira Shimizu, and Isaku Okamoto
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Carnitine ,Free carnitine ,Induction chemotherapy ,Head and neck cancer ,Cisplatin ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Carnitine is related to malaise, and cisplatin is associated with decreased carnitine. The purpose of this study was to elucidate the effects of one course of induction chemotherapy (IC) for head and neck cancer on blood carnitine levels, focusing on free carnitine (FC). Methods This single-center prospective study investigated 20 patients diagnosed with primary head and neck cancer who underwent IC with cisplatin, docetaxel, and 5-fluorouracil. FC, acylcarnitine (AC), and total carnitine (TC) levels were measured before starting therapy and on Days 7 and 21 after starting IC. In addition, malaise was evaluated before and after therapy using a visual analog scale (VAS). Results All subjects were men and the most common primary cancer site was the hypopharynx (9 patients). FC levels before starting therapy and on Days 7 and 21 were 47.7 ± 2.2 μM/mL, 56.7 ± 2.2 μM/mL, and 41.1 ± 1.9 μM/mL, respectively. Compared with the baseline before starting therapy, FC had significantly decreased on Day 21 (p = 0.007). AC levels before starting therapy and on Days 7 and 21 were 12.5 ± 1.2 μM/mL, 13.6 ± 1.4 μM/mL, and 10.7 ± 0.7 μM/mL, respectively. TC levels before starting therapy and on Days 7 and 21 were 60.2 ± 2.5 μM/mL, 70.2 ± 3.3 μM/mL, and 51.7 ± 2.3 μM/mL, respectively. No significant differences in AC, TC or VAS were seen before the start of therapy and on Day 21. Conclusions After IC, a latent decrease in FC occurred without any absolute deficiency or subjective malaise.
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- 2021
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13. Extraction behaviors of platinum group metals in simulated high-level liquid waste by a hydrophobic ionic liquid bearing an amino moiety
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Hao Wu, Seong-Yun Kim, Tadayuki Takahashi, Haruka Oosugi, Tatsuya Ito, and Kiyoshi Kanie
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Ionic liquid ,Platinum group metals ,Simulated high-level liquid waste ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
A hydrophobic ionic liquid including an amino moiety ([DiOcAPmim][NTf2]) was synthesized. Its extraction behaviors towards Pd(II), Ru(III), Rh(III) were investigated in nitric acid aqueous solution as a function of contact time, effect of concentration of nitric acid, effect of temperature, and effect of co-existing metal ions. The extraction kinetics of Pd(II) was fairly fast and extraction equilibrium can be attained within only 5 min under the [HNO3] = 2.05 M. When [HNO3]< 1 M, the extraction percentage of Pd(II), Ru(III), Rh(III) were all above 80%. When [HNO3] reached 2 M, all of the extraction percentage decreased and in an order of Pd(II)>Ru(III)>Rh(III). When [HNO3]> 2 M, the extraction performance gradually recovered. The effect of temperature can slightly affect the extraction performance of Pd(II). Furthermore, in simulated high-level liquid waste, [DiOcAPmim][NTf2] showed a better preference towards Pd(II) under the interference of various other co-existing metal ions.
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- 2021
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14. Can Non-expert Physicians Use the Japan Narrow-band Imaging Expert Team Classification to Diagnose Colonic Polyps Effectively?
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Shinya Sugimoto, Tadashi Yabana, Tatsuma Nomura, Satoshi Hayashi, Naoko Okuda, Taishi Temma, Yuki Hashimoto, Tatsuya Ito, Mayuko Takami, Jun Oyamada, and Akira Kamei
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jnet classification ,colonoscopy ,colorectal adenoma ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Objectives: In 2014, the Japan narrow-band imaging expert team (JNET) proposed the first unified colorectal narrow-band imaging magnifying classification system, the JNET classification. The clinical usefulness of this system has been well established in JNET member institutions, but its suitability for use by “non-expert physicians” (physicians with no expertise in the use of JNET classification) remains unclear. This study aimed to examine the clinical usefulness of the JNET classification by “non-expert physicians”. Methods: We retrospectively analyzed 852 consecutive patients who underwent screening colonoscopy following a positive fecal occult blood test between January 2017 and May 2018. Endoscopic results from colon polyp diagnosis by physicians who started using the JNET classification (JNET group) were compared with those of physicians who did not (control group). Mann-Whitney U test and Fisher's exact test were used to compare continuous and categorical variables, respectively. Results: The median patient age was 68 years, and the male-to-female ratio was 1:0.84. When no lesions were found, the median withdrawal time was significantly different between groups (JNET group: 12 min; control group: 15 min; P < 0.01). The number of resected adenomas per colonoscopy was significantly higher in the JNET group (1.7) than in the control group (1.2; P < 0.01). Among the resected lesions, 8.9% in the JNET group and 17% in the control group were non-neoplastic lesions that did not require resection (P < 0.01). Conclusions: Colon polyp diagnosis using the JNET classification can reduce unnecessary resection during magnifying colonoscopy when conducted by “non-expert physicians”.
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- 2020
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15. Prevalence and Clinical Implications of the Mirror and TV Signs in Advanced Alzheimer’s Disease and Dementia with Lewy Bodies
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Yasuhiro Nagahama, Toshiya Fukui, Hiroshi Akutagawa, Hiroko Ohtaki, Momoka Okabe, Tatsuya Ito, Hiroko Suga, and Hiroshige Fujishiro
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delusional misidentification syndrome ,sense of self ,lewy body dementia ,alzheimer’s disease ,misidentification of television ,misidentification of the mirror image ,Neurology. Diseases of the nervous system ,RC346-429 ,Geriatrics ,RC952-954.6 - Abstract
Objective: To explore the prevalence and clinical implications of the mirror and TV signs in the moderate to advanced stages of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Methods: We retrospectively examined the prevalence of clinical and psychiatric symptoms including the mirror and TV signs in 200 subjects with AD and 200 with DLB and evaluated the relationships among the symptoms. Results: The mirror sign was found in 3.0% of AD and 4.5% of DLB subjects. The TV sign was found in 1.5% of AD and 4.0% of DLB subjects. The prevalence of the mirror and TV signs was not significantly different between the AD and DLB groups. Visual hallucination, visual illusion, misidentification of person, and sleep talking were significantly more frequent in DLB than in AD subjects. The mirror sign was significantly associated with lower Mini-Mental State Examination scores, whereas the TV sign was significantly associated with the misidentification of person. Conclusions: Both the mirror and TV signs were rare even in the moderate to advanced stages of AD and DLB. The mirror sign may be independent from other delusional misidentification syndromes (DMSs). Being associated mainly with global cognitive decline, the mirror sign is unlikely attributed to any specific cognitive impairment or the dysfunction of localized brain areas. In contrast, the TV sign was significantly more often coexistent with the misidentification of person, suggesting that the TV sign may partly share common neuropsychological mechanisms with DMSs.
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- 2020
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16. Is complete stone removal for choledocholithiasis always necessary in extremely elderly patients?
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Naoko Okuda, Shinya Sugimoto, Haruka Nakamura, Hirohisa Hisada, Taishi Temma, Yuki Hashimoto, Satoshi Hayashi, Tatsuya Ito, Mayuko Takami, Jun Oyamada, and Akira Kamei
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choledocholithiasis ,extremely elderly ,plastic stent ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and Aim Endoscopic stone removal has some complications. Although the life expectancy of elderly patients has increased dramatically worldwide, little information is available on the necessity of complete endoscopic stone removal in extremely elderly patients. This study aimed to evaluate the safety and efficacy of complete endoscopic stone removal in extremely elderly patients. Methods All extremely elderly patients (>90 years) who underwent endoscopic stone removal for choledocholithiasis at our hospital between January 2012 and January 2017 were retrospectively evaluated. The included patients were divided into complete stone removal and incomplete stone removal groups. Complication rate, overall survival (OS), and disease‐specific survival (DSS) rates were compared between the two groups. Results Overall, 73 patients were included in this study. The median number of stones was one (range, 0–10) and two (range, 1–12) (P = 0.043), while the median diameter of the largest stones was 9 (range, 0–27) and 14 (range, 5–46) mm (P = 0.001) in the complete and incomplete stone removal groups, respectively. During the follow‐up period, OS was 60% and 39% and DSS was 95% and 97% in the complete and incomplete stone removal groups, respectively. Kaplan–Meier analysis found no significant difference in OS and DSS between the two groups (P = 0.052 and P = 0.646, respectively). Conclusion Complete stone removal might not always be necessary in extremely elderly patients aged ≥90 years.
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- 2020
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17. Legal and ethical framework for global health information and biospecimen exchange - an international perspective
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Lara Bernasconi, Selçuk Şen, Luca Angerame, Apolo P. Balyegisawa, Damien Hong Yew Hui, Maximilian Hotter, Chung Y. Hsu, Tatsuya Ito, Francisca Jörger, Wolfgang Krassnitzer, Adam T. Phillips, Rui Li, Louise Stockley, Fabian Tay, Charlotte von Heijne Widlund, Ming Wan, Creany Wong, Henry Yau, Thomas F. Hiemstra, Yagiz Uresin, and Gabriela Senti
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Data sharing ,Biobanking ,Big data ,Research policies ,International exchange ,Medical philosophy. Medical ethics ,R723-726 - Abstract
Abstract Background The progress of electronic health technologies and biobanks holds enormous promise for efficient research. Evidence shows that studies based on sharing and secondary use of data/samples have the potential to significantly advance medical knowledge. However, sharing of such resources for international collaboration is hampered by the lack of clarity about ethical and legal requirements for transfer of data and samples across international borders. Main text Here, the International Clinical Trial Center Network (ICN) reports the legal and ethical requirements governing data and sample exchange (DSE) across four continents. The most recurring requirement is ethical approval, whereas only in specific conditions approval of national health authorities is required. Informed consent is not required in all sharing situations. However, waiver of informed consent is only allowed in certain countries/regions and under certain circumstances. The current legal and ethical landscape appears to be very complex and under constant evolution. Regulations differ between countries/regions and are often incomplete, leading to uncertainty. Conclusion With this work, ICN illuminates the unmet need for a single international collaborative framework to facilitate DSE. Harmonising requirements for global DSE will reduce inefficiency and waste in research. There are many challenges to realising this ambitious vision, including inconsistent terminology and definitions, and heterogeneous and dynamic legal constraints. Here, we identify areas of agreement and significant difference as a necessary first step towards facilitating international collaboration. We propose the establishment of a working group to continue the comparison across jurisdictions, create a standardised glossary and define a set of basic principles and fundamental requirements for DSE.
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- 2020
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18. The importance of side branch preservation in the treatment of chronic total occlusions with bifurcation lesions
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Yuya Adachi, Yoshihisa Kinoshita, Akira Murata, Yoshiaki Kawase, Munenori Okubo, Yoriyasu Suzuki, Tatsuya Ito, Hitoshi Matsuo, and Takahiko Suzuki
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Bifurcation ,Coronary chronic total occlusion ,Side branch ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objectives: The aim of this study was to identify the predictive factors for suboptimal result in side branch (SB) in chronic total occlusion (CTO) bifurcation lesions and clinical outcomes of patients with suboptimal result in SB. Background: There is little evidence on the optimal strategy for bifurcation lesions in CTO. Methods: We retrospectively reviewed 314 consecutive bifurcation lesions in CTO with SB ≥ 2.5 mm in 3 hospitals from March 2010 to June 2018. Patients were divided into the two groups based on the suboptimal SB treatment (SST) and optimal SB treatment (OST) groups. The baseline characteristics, procedural and clinical outcomes were compared between the two groups. This study also evaluated the predictors of suboptimal result in SB. Results: Suboptimal result in SB occurred in 47 cases. Presence of stenosis in SB, bifurcations located within the occluded segment and sub-intimal tracking at SB ostium was an independent predictor of suboptimal result in SB. The cumulative incidence of target lesion revascularization (TLR) in all lesions was not significantly different between the two groups, however, TLR in right coronary artery (RCA) was significantly higher in the SST group. In the Cox regression analysis, suboptimal result in SB in RCA and sub-intimal tracking were independent predictors of TLR for MB. In patients with bifurcations located within the occluded segment, usage of two-stent technique was significantly lower in the SST group. Conclusions: Meticulous procedures are required for SB preservation to improve not only SB prognosis but also MB, especially in RCA.
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- 2021
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19. High-Speed Alumina Stereolithography
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Fiona Spirrett, Tatsuya Ito, and Soshu Kirihara
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discrete element method ,ray tracing ,stereolithography ,alumina ,additive manufacturing ,ceramics ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The additive manufacturing of ceramics offers a reliable and repeatable method for fabricating parts with complex geometries. To compete with conventional ceramic forming methods, the time and cost associated with material and process optimization for ceramic stereolithography should be improved. Computational analysis methods can be utilized to reduce the number of experimental steps required for material and process optimization. This work used the discrete element method and ray tracing analyses to predict suitable material parameters and processing conditions for ceramic stereolithography. The discrete element method was used to create alumina particle dispersion models to predict suitable paste compositions, and ray tracing was used to predict suitable laser power and scan speed to achieve a sufficient curing depth for stereolithography processing. The predicted conditions of paste composition and processing parameters were comparable to experimental values, reducing the number of experimental iterations required for process optimization. Furthermore, suitable processing parameters for high-speed fabrication by stereolithography was predicted, achieving a processing speed much faster than previously reported ceramic stereolithography. The reduction in process optimization timeline, and the increase in fabrication speed, could increase the appeal of ceramic stereolithography to industry.
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- 2022
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20. Resistance of t(17;19)‐acute lymphoblastic leukemia cell lines to multiagents in induction therapy
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Atsushi Watanabe, Takeshi Inukai, Keiko Kagami, Masako Abe, Masatoshi Takagi, Takashi Fukushima, Hiroko Fukushima, Toru Nanmoku, Kiminori Terui, Tatsuya Ito, Tsutomu Toki, Etsuro Ito, Junya Fujimura, Hiroaki Goto, Mikiya Endo, Thomas Look, Mark Kamps, Masayoshi Minegishi, Junko Takita, Toshiya Inaba, Hiroyuki Takahashi, Akira Ohara, Daisuke Harama, Tamao Shinohara, Shinpei Somazu, Hiroko Oshiro, Koshi Akahane, Kumiko Goi, and Kanji Sugita
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chemotherapy ,hematalogical cancer ,leukemia ,pediatric cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract t(17;19)(q21‐q22;p13), responsible for TCF3‐HLF fusion, is a rare translocation in childhood B‐cell precursor acute lymphoblastic leukemia(BCP‐ALL). t(1;19)(q23;p13), producing TCF3‐PBX1 fusion, is a common translocation in childhood BCP‐ALL. Prognosis of t(17;19)‐ALL is extremely poor, while that of t(1;19)‐ALL has recently improved dramatically in intensified chemotherapy. In this study, TCF3‐HLF mRNA was detectable at a high level during induction therapy in a newly diagnosed t(17;19)‐ALL case, while TCF3‐PBX1 mRNA was undetectable at the end of induction therapy in most newly diagnosed t(1;19)‐ALL cases. Using 4 t(17;19)‐ALL and 16 t(1;19)‐ALL cell lines, drug response profiling was analyzed. t(17;19)‐ALL cell lines were found to be significantly more resistant to vincristine (VCR), daunorubicin (DNR), and prednisolone (Pred) than t(1;19)‐ALL cell lines. Sensitivities to three (Pred, VCR, and l‐asparaginase [l‐Asp]), four (Pred, VCR, l‐Asp, and DNR) and five (Pred, VCR, l‐Asp, DNR, and cyclophosphamide) agents, widely used in induction therapy, were significantly poorer for t(17;19)‐ALL cell lines than for t(1;19)‐ALL cell lines. Consistent with poor responses to VCR and DNR, gene and protein expression levels of P‐glycoprotein (P‐gp) were higher in t(17;19)‐ALL cell lines than in t(1;19)‐ALL cell lines. Inhibitors for P‐gp sensitized P‐gp‐positive t(17;19)‐ALL cell lines to VCR and DNR. Knockout of P‐gp by CRISPRCas9 overcame resistance to VCR and DNR in the P‐gp‐positive t(17;19)‐ALL cell line. A combination of cyclosporine A with DNR prolonged survival of NSG mice inoculated with P‐gp‐positive t(17;19)‐ALL cell line. These findings indicate involvement of P‐gp in resistance to VCR and DNR in Pgp positive t(17;19)‐ALL cell lines. In all four t(17;19)‐ALL cell lines, RAS pathway mutation was detected. Furthermore, among 16 t(1;19)‐ALL cell lines, multiagent resistance was usually observed in the cell lines with RAS pathway mutation in comparison to those without it, suggesting at least a partial involvement of RAS pathway mutation in multiagent resistance of t(17;19)‐ALL.
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- 2019
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21. Application of Simultaneous Immobilization of Borate and Arsenate in Mine Drainages by Co-Precipitation with Hydroxyapatite in a Pilot Scale
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Yoshikazu HAYASHI, Binglin GUO, Tsuyoshi HIRAJIMA, Tatsuya ITO, Takeshi NAKAMURA, and Keiko SASAKI
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borate ,arsenate ,hydroxyapatite ,co-precipitation ,mine drainages ,pilot scale ,Mining engineering. Metallurgy ,TN1-997 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Removal of borate in mine drainages by co-precipitation with hydroxyapatite (HAp) was developed from a laboratory scale to a pilot scale. Weakly acidic initial pH facilitated to enhance dissolution of Ca(OH)2 and decrease the dissolved carbonate concentration, leading to efficient immobilization of borate and arsenate. The NH4H2PO4 lowered best the equilibrium B concentration among different phosphate sources, avoiding the lattice strain of HAp. The added molar ratio of P/Ca significantly influenced the decreasing behavior of the B concentration, showing the optimal value of 0.3. In case of P/Ca larger than 0.30, the excess concentration of PO43- was probably adsorbed on Ca(OH)2 particles to prevent the dissolution, resulting in inhibiting the formation of HAp. In case of P/Ca smaller than 0.30, the production of HAp was limited, leading to less immobilized borate. All the optimized conditions as above were applied to the pilot scale with a 250 L reactor, where borate concentration was effectively reduced in also both batch and continuous tests.
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- 2019
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22. Characteristics of Medical Products Comprising Human Cells, Genes, or Tissues Developed in Japan and the European Union Compared via Public Assessment Reports
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Ryosuke Kurauchi, Hiroi Kasai, and Tatsuya Ito
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advanced therapy medicinal products (ATMP) ,cell therapy ,gene therapy ,marketing access ,regenerative medicine ,regenerative medicine products ,Biotechnology ,TP248.13-248.65 - Abstract
Medical products comprising human cells, genes, and tissues have been developed for clinical applications worldwide, and their developmental environment has been established. These products can be imported and exported, but marketing authorization regulations are complicated among regions. This investigation was conducted to identify the characteristics of medical products comprising human cells, genes, and tissues. We used website data, books from survey companies, and reports from public agencies to conduct two investigations. We used website data to conduct a general information survey of 143 cell-therapy and gene-therapy products sold in 24 countries and public assessment reports to individually survey non-clinical and clinical developments of 18 cell-therapy and gene-therapy products developed in Japan and the European Union (EU). The first survey revealed that the numbers of products used in orthopedic surgery and dermatology have increased since 2000, and the numbers of hematological products have increased since 2011. The second investigation revealed that fewer orphaned products were developed in Japan than in the EU. The most appropriate dose was 1.2 × 108 cells per injection per adult. Clinical trials to determine the most appropriate dose were conducted in the EU but not in Japan. No non-clinical immunogenicity tests for autogenous products were conducted in Japan or the EU. Pharmacokinetics tests were not individually performed for sheet-form products. Both in vivo and in vitro pharmacological tests were more likely to be conducted in the EU, while only one or the other was conducted in Japan. Furthermore, in Japan, carcinogenicity tests were performed based on non-clinical technical guidance, while in the EU, these tests were determined according to each product's features. Fewer clinical trials were performed, and fewer subjects per product were used in Japan than in the EU. Many aspects of the clinical and non-clinical development of medical products comprising human cells, genes, and tissues differ between Japan and the EU. Analyzing these differences will enable the safe and rapid distribution of these products to clinical sites.
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- 2020
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23. Midterm Clinical Impacts of Biodegradable Polymer Everolimus-Eluting Stents Compared with Durable Polymer Everolimus-Eluting Stents: A 3-Year Propensity-Matched Study
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Hiroaki Matsuda, Ai Kagase, Takahiro Tokuda, Yusuke Ochiumi, Akira Murata, Yoriyasu Suzuki, and Tatsuya Ito
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objectives. Our aim was to evaluate the safety and efficacy of biodegradable polymer everolimus-eluting stents (BP-EES) compared with durable polymer everolimus-eluting stents (DP-EES) in midterm. Background. There are few data about midterm clinical outcomes of BP-EES compared with DP-EES. Methods and Results. Between January 2016 and December 2017, 395 consecutive patients were treated with BP-EES and 391 consecutive patients were treated with DP-EES in Nagoya Heart Center. The primary endpoint was a 3-year cumulative incidence of target lesion failure (TLF) defined as cardiac death, target vessel myocardial infarction (MI), and clinical indicated target lesion revascularization (TLR). Moreover, clinical indicated target vessel revascularization (TVR) and definite stent thrombosis (ST) were also evaluated as the secondary endpoints. After propensity score matching, 327 patients were selected in each group. At 3 years, the cumulative incidence of TLF was 4.5% in the BP-EES group versus 6.5% in DP-EES (adjusted HR 0.67 (95% CI 0.33–1.30), log-rank P=0.23). Regarding the individual components of the TLF at 3 years, the cumulative incidence of target vessel MI was significantly lower in BP-EES than in DP-EES (0% versus 1.9%: adjusted HR 0.83 (95% CI 0.71–0.97), log-rank P=0.01), but there was no difference between BP-EES and DP-EES in the incidence of cardiac death and clinically indicated TLR. The cumulative 3-year incidence of definite ST was significantly lower in BP-EES than in DP-EES (0% versus 1.6%, log-rank P=0.02). Conclusions. There were no significant differences of TLF between BP-EES and DP-EES within 3 years. In this study, BP-EES seems to prevent definite ST and be safer than DP-EES in midterm.
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- 2020
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24. The Efficacy of a Scaffold-free Bio 3D Conduit Developed from Autologous Dermal Fibroblasts on Peripheral Nerve Regeneration in a Canine Ulnar Nerve Injury Model: A Preclinical Proof-of-Concept Study
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Sadaki Mitsuzawa, Ryosuke Ikeguchi, Tomoki Aoyama, Hisataka Takeuchi, Hirofumi Yurie, Hiroki Oda, Souichi Ohta, Mika Ushimaru, Tatsuya Ito, Mai Tanaka, Yoshihiro Kunitomi, Manami Tsuji, Shizuka Akieda, Koichi Nakayama, and Shuichi Matsuda
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Medicine - Abstract
Autologous nerve grafting is widely accepted as the gold standard treatment for segmental nerve defects. To overcome the inevitable disadvantages of the original method, alternative methods such as the tubulization technique have been developed. Several studies have investigated the characteristics of an ideal nerve conduit in terms of supportive cells, scaffolds, growth factors, and vascularity. Previously, we confirmed that biological scaffold-free conduits fabricated from human dermal fibroblasts promote nerve regeneration in a rat sciatic nerve injury model. The purpose of this study is to evaluate the feasibility of biological scaffold-free conduits composed of autologous dermal fibroblasts using a large-animal model. Six male beagle dogs were used in this study. Eight weeks before surgery, dermal fibroblasts were harvested from their groin skin and grown in culture. Bio 3D conduits were assembled from proliferating dermal fibroblasts using a Bio 3D printer. The ulnar nerve in each dog’s forelimb was exposed under general anesthesia and sharply cut to create a 5 mm interstump gap, which was bridged by the prepared 8 mm Bio 3D conduit. Ten weeks after surgery, nerve regeneration was investigated. Electrophysiological studies detected compound muscle action potentials (CMAPs) of the hypothenar muscles and motor nerve conduction velocity (MNCV) in all animals. Macroscopic observation showed regenerated ulnar nerves. Low-level hypothenar muscle atrophy was confirmed. Immunohistochemical, histological, and morphometric studies confirmed the existence of many myelinated axons through the Bio 3D conduit. No severe adverse event was reported. Hypothenar muscles were re-innervated by regenerated nerve fibers through the Bio 3D conduit. The scaffold-free Bio 3D conduit fabricated from autologous dermal fibroblasts is effective for nerve regeneration in a canine ulnar nerve injury model. This technology was feasible as a treatment for peripheral nerve injury and segmental nerve defects in a preclinical setting.
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- 2019
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25. Management of Multiple Arteriovenous Malformations of the Small Bowel
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Masahiro Hirakawa, Rie Ishizuka, Masanori Sato, Naotaka Hayasaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Tatsuya Ito, Takayuki Nobuoka, Koji Miyanishi, Masayoshi Kobune, Ichiro Takemasa, and Junji Kato
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Medicine - Abstract
A 62-year-old Japanese female was referred to our hospital with gastrointestinal bleeding. Although small-bowel bleeding was suspected, no bleeding source was identified by enhanced computed tomography (CT), video capsule endoscopy (VCE), and double-balloon enteroscopy (DBE). Five years later, the patient had recurrent intermittent bloody stools with a significant decrease in hemoglobin levels. Although no active bleeding was observed on antegrade DBE, we detected a pulsatile submucosal uplift accompanied by a small red patch on the top of the uplift in the jejunum. Arteriovenous malformation (AVM) was suspected as the cause of small-bowel bleeding. Multiple-phase CT showed a number of small vascular ectasias during the arterial phase in the jejunum, and we confirmed the presence of multiple AVMs in the jejunum by selective angiography. To identify the location of the lesions and determine the minimal surgical margins, we performed intraoperative selective angiography with indocyanine green (ICG) injection. This technique allowed us to clearly observe the region and perform segmental small-bowel resection with minimal surgical margin. The patient reported that she has had no gastrointestinal bleeding at the two years follow-up visit.
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- 2019
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26. Real-World, Long-Term Outcomes of Nivolumab Therapy for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck and Impact of the Magnitude of Best Overall Response: A Retrospective Multicenter Study of 88 Patients
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Takashi Matsuki, Isaku Okamoto, Chihiro Fushimi, Hideaki Takahashi, Takuro Okada, Takahito Kondo, Hiroki Sato, Tatsuya Ito, Kunihiko Tokashiki, Kiyoaki Tsukahara, Kenji Hanyu, Tatsuo Masubuchi, Yuichiro Tada, Kouki Miura, Go Omura, Michi Sawabe, Daisuke Kawakita, and Taku Yamashita
- Subjects
head and neck squamous cell carcinoma ,nivolumab ,long-term survival ,best overall response ,real-world outcome ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
No real-world, long-term outcomes of immunotherapy with nivolumab for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) have yet been reported. Furthermore, the prognostic impact of the best overall response (BOR) of this therapy remains unclear. We conducted a multi-institutional cohort study of the long-term efficacy and safety of this therapy and investigated prognostic factors associated with survival. Further, we evaluated the relationship between BOR and survival. Median follow-up time was 25.9 months. Median overall survival (OS) was 9.6 months, and two-year survival rate was 25.0%. Median progression-free survival (PFS) was 3.7 months, and two-year PFS rate was 19.6%. BOR was assessed as complete response (CR) in 6%, partial response (PR) in 13%, stable disease (SD) in 30%, and progressive disease (PD) in 52% of the patients. Overall response rate was 18%, and disease control rate was 48%. For immune-related adverse events (irAEs), 38 irAEs were detected in 29 patients. On multivariate analysis, the development of irAEs was significantly associated with better OS and PFS. Better BOR was significantly associated with longer OS and PFS. These findings demonstrate the long-term efficacy and safety of nivolumab therapy for R/M SCCHN in a real-world setting. The magnitude of BOR and the development of irAEs might be useful surrogate markers of survival.
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- 2020
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27. Magnetoresistance and Thermal Transformation Arrest in Pd2Mn1.4Sn0.6 Heusler Alloys
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Xiao Xu, Hironari Okada, Yusuke Chieda, Naoki Aizawa, Daiki Takase, Hironori Nishihara, Takuo Sakon, Kwangsik Han, Tatsuya Ito, Yoshiya Adachi, Takumi Kihara, Ryosuke Kainuma, and Takeshi Kanomata
- Subjects
electric resistivity ,magnetoresistance ,Pd–Mn–Sn ,Heusler alloy ,martensitic transformation ,thermal transformation arrest ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
The magnetization, electric resistivity, and magnetoresistance properties of Pd 2 Mn 1 . 4 Sn 0 . 6 Heusler alloys were investigated. The Curie temperature of the parent phase, martensitic transformation temperatures, and magnetic field dependence of the martensitic transformation temperatures were determined. The magnetoresistance was investigated from 10 to 290 K, revealing both intrinsic and extrinsic magnetoresistance properties for this alloy. A maximum of about − 3 . 5 % of intrinsic magnetoresistance under 90 kOe and of about − 30 % of extrinsic magnetoresistance under 180 kOe were obtained. Moreover, the thermal transformation arrest phenomenon was confirmed in the Pd 2 Mn 1 . 4 Sn 0 . 6 alloy, and an abnormal heating-induced martensitic transformation (HIMT) behavior was observed.
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- 2019
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28. Differences in Investigator-Initiated Trials between Japan and Other Countries: Analyses of Clinical Trials Sponsored by Academia and Government in the ClinicalTrials.gov Registry and in the Three Japanese Registries.
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Tatsuya Ito
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Medicine ,Science - Abstract
BACKGROUND:Following the amendment of the Pharmaceutical Affairs Law in Japan in 2003 researchers were permitted to begin investigator-initiated trials (IITs). In subsequent years, however, the number of IITs remained low. In other countries in Asia as well as in Europe, North America, and South Africa, the number of IITs has increased over the past decade. The differences in the characteristics of IITs between Japan and other countries are unknown. Some studies have analyzed the characteristics of all clinical trials according to registry databases, but there has been less research focusing on IITs. AIMS:The purpose of this study is to analyze the characteristics of IITs in the ClinicalTrials.gov registry and in the three Japanese registries, to identify differences in IITs between Japan and other countries. METHODS:Using Thomson Reuters Pharma™, trials sponsored by academia and government as IITs in 2010 and registered in ClinicalTrials.gov were identified. IITs from 2004 to 2012 in Japan were identified in the three Japanese registries: the University Hospital Medical Information Network Clinical Trials Registry, the Japan Pharmaceutical Information Center Clinical Trials Information, and the Japan Medical Association Center for Clinical Trials, Clinical Trials Registry. Characterization was made of the trial purposes, phases, participants, masking, arms, design, controls, and other data. RESULTS:New and revised IITs registered in ClinicalTrials.gov during 2010 averaged about 40% of all sponsor-identified trials. IITs were nearly all early-phase studies with small numbers of participants. A total of 56 Japanese IITs were found over a period of 8 years, and these were also almost nearly all early-phase studies with small numbers of participants. CONCLUSION:There appear to be no great differences between Japan and other countries in terms of characteristics of IITs. These results should prompt a new review of the IIT environment in Japan.
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- 2016
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29. Questionnaire to Survey Cosmetic Outcomes in Laparoscopic Surgery for Colorectal Cancer.
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Masaaki Miyo, Ichiro Takemasa, Koichi Okuya, Tatsuya Ito, Emi Akizuki, Tadashi Ogawa, Ai Noda, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Maho Toyota, Akina Kimura, and Mitsugu Sekimoto
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- 2024
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30. Exploration of Alkyl Group Effects on the Molecular Packing of 5,15-Disubstituted Tetrabenzoporphyrins toward Efficient Charge-Carrier Transport
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Eunjeong Jeong, Tatsuya Ito, Kohtaro Takahashi, Tomoyuki Koganezawa, Hironobu Hayashi, Naoki Aratani, Mitsuharu Suzuki, and Hiroko Yamada
- Subjects
General Materials Science - Abstract
The high design flexibility of organic semiconductors should lead to diverse and complex electronic functions. However, currently available high-performance organic semiconductors are limited in variety; most of p-type materials are based on thienoacenes or related one-dimensionally (1D) extended π-conjugated systems. In an effort to expand the diversity of organic semiconductors, we are working on the development of tetrabenzoporphyrin (BP) derivatives as active-layer components of organic electronic devices. BP is characterized by its large, rigid two-dimensionally (2D) extended π-framework with high light absorptivity and therefore is promising as a core building unit of organic semiconductors for optoelectronic applications. Herein, we demonstrate that BP derivatives can afford field-effect hole mobilities of4 cm
- Published
- 2023
31. A case of Kleine–Levin syndrome arising during chemotherapy: efficacy of oral L-carnitine
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Ryuji Furihata, Daisuke Endo, Kenichi Nagaoka, Ayako Hori, Tatsuya Ito, Kazuo Chin, and Toshiki Akahoshi
- Subjects
Neuropsychology and Physiological Psychology ,Neurology ,Physiology ,Physiology (medical) - Published
- 2022
32. Long-term impairment of social-related quality of life in COVID-19 pneumonia survivors: a prospective longitudinal study
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Takahiro Ando, Sho Shimada, Jun Sugihara, Koji Takayama, Masayoshi Kobayashi, Yoshihiro Miyashita, Tatsuya Ito, Kaori Okayasu, Shun Tsuyuki, Takehiko Ohba, Masafumi Doi, Hiroaki Saito, Toshihide Fujie, Tomoshige Chiaki, Atsushi Nakagawa, Tatsuhiko Anzai, Kunihiko Takahashi, Sho Shibata, Tomoya Tateishi, and Yasunari Miyazaki
- Abstract
Long-term sequelae of COVID-19 can affect health-related quality of life (HRQOL). We examined the long-term impact of COVID-19 on HRQOL and elucidated factors associated with low HRQOL. Discharged COVID-19 patients were assessed at 3 and 6 months after disease onset. The patients completed a medical examination and SF-36 questionnaire at the two time points and underwent pulmonary function testing at 6 months. All had undergone computed tomography (CT) imaging upon hospital admission. Of the 74 included patients, 38% reported respiratory symptoms at 3 months and 26% at 6 months. The aggregated SF-36 scores declined in the role/social component summary (RCS), a category related to social activity. Patients with respiratory sequelae or impaired pulmonary function had lower RCS scores. There was a negative linear relation between the RCS score and the CT score, which reflected the extent of COVID-19 pneumonia (3 months, P = 0.0024; 6 months, P = 0.0464). A high CT score (≥ 10 points) predicted a low RCS score at 6 months (P = 0.026). This study highlights the long-term impairment of RCS and its associations with respiratory sequelae. The study also emphasizes the importance of radiological findings in predicting long-term HRQOL outcomes after COVID-19.
- Published
- 2023
33. Extraction behavior of a novel functionalized ionic liquid for separation of platinum group metals from aqueous nitric acid solution
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Naoki Osawa, Tatsuya Ito, Tadayuki Takahashi, Seong Yun Kim, Haruka Oosugi, and Ryuji Nagaishi
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chemistry.chemical_compound ,Aqueous solution ,chemistry ,Nitric acid ,Inorganic chemistry ,Ionic liquid ,Extraction (chemistry) ,Ionic Liquids ,Water ,Platinum group ,Nitric Acid ,Platinum ,Analytical Chemistry - Abstract
A novel ionic liquid (IL) functionalized with thiodiglycol amic acid containing a soft S donor was synthesized for the effective and efficient extraction of platinum group metals (Ru, Rh, and Pd) from aqueous nitric acid solutions, such as high-level radioactive liquid waste (HLLW). The IL enabled rapid extraction of Pd(II) with an extraction ratio of approximately 100%. The extractions of Ru(III) and Rh(III) by the IL were slower than that of Pd(II), but the rates were accelerated by temperature elevation. The extractions of Ru(III) and Rh(III) at 50 °C reached equilibrium within 4 and 8 h, respectively, with the extraction ratios of over 90% without assisting agents or other methods for the extraction system. Furthermore, the IL could extract more than 90% of Ru(III), Rh(III), and Pd(II) from the simulated HLLW within 2 h at 50 °C.
- Published
- 2022
34. Selective Hydrothermal Synthesis of Water-Soluble CdTe and CdTe/CdS Colloidal Quantum Dots by Controlling the Te/Cd Molar Ratio of the Precursor Solution
- Author
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TaeGi Lee, Kunio Shimura, DaeGwi Kim, and Tatsuya Ito
- Subjects
chemistry.chemical_classification ,テルル化カドミウム ,Quantum dots ,Thermal decomposition ,量子ドット ,General Chemistry ,CdTe ,Hydrothermal circulation ,Cadmium telluride photovoltaics ,chemistry ,Chemical engineering ,Quantum dot ,Molar ratio ,Thiol ,Hydrothermal synthesis ,水熱合成 ,Layer (electronics) - Abstract
During the synthesis of CdTe quantum dots (QDs) by the hydrothermal method, a CdS shell layer is naturally formed by the thermal decomposition of thiol ligands, and CdTe/CdS core/shell QDs are produced. Herein, we investigate the selective synthesis of CdTe and CdTe/CdS QDs to control the thermal decomposition of thiol ligands by changing the Te/Cd molar ratio of the precursor solutions. ...
- Published
- 2021
35. Giant Gastrointestinal Stromal Tumor of the Stomach Treated by Proximal Gastrectomy with Esophagogastrostomy Using the Double-Flap Technique after: A Case Report
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Daisuke Kyuno, Takayuki Nobuoka, Toshihiko Nishidate, Takahiro Korai, Kenji Okita, Ichiro Takemasa, Tatsuya Ito, Minoru Nagayama, Ayumi Kanazawa, and Masafumi Imamura
- Subjects
Pathology ,medicine.medical_specialty ,medicine.anatomical_structure ,Proximal gastrectomy ,business.industry ,Stomach ,Gastroenterology ,Medicine ,Surgery ,Stromal tumor ,business - Published
- 2021
36. Laparoscopic low anterior resection for rectal cancer wherein the inferior mesenteric artery arose from the superior mesenteric artery: a case report
- Author
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Minoru Nagayama, Emi Akizuki, Toshihiko Nishidate, Daisuke Kyuno, Ichiro Takemasa, Takayuki Nobuoka, Tatsuya Ito, Masafumi Imamura, Koichi Okuya, Atsushi Hamabe, Takeshi Murakami, Ryo Miura, Yu Sato, Takahiro Korai, Masayuki Ishii, and Kenji Okita
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Inferior mesenteric artery ,RD1-811 ,Colorectal cancer ,business.industry ,Sigmoid colon ,Rectum ,Colonoscopy ,Case Report ,medicine.disease ,Middle colic artery ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,medicine.artery ,Superior mesenteric artery ,medicine ,Surgery ,Radiology ,Rectal cancer ,business ,Indocyanine green - Abstract
Background Few cases have been reported of colorectal cancer with inferior mesenteric artery (IMA) branching abnormalities; therefore, the lymphatic flow in such cases remains unknown. We report the first case of locally advanced rectal cancer in which the IMA arose from the superior mesenteric artery (SMA) in which we achieved to visualize the lymphatic flow. Case presentation A 65-year-old woman complaining of bloody stools was investigated in our hospital and suspected with rectal cancer. Colonoscopy and abdominal enhanced computed tomography (CT) revealed a circumscribed, localized ulcerative tumor in the rectum. 3-Dimensional contrast-enhanced computed tomography (3D-CT) showed that the IMA arose from the SMA. The patient was diagnosed with rectal cancer (cT3N0M0, cStage IIa) and laparoscopic low anterior resection was performed. The sigmoid colon was resected using the medial approach. Only the plexus of the colic branch of the lumbar splanchnic nerve was observed at the site where the root of the IMA usually exists and showed interruption of the indocyanine green (ICG) fluorescence-illuminated lymphatics. The root of the IMA was ligated, and Japanese D3 lymphadenectomy was performed, preserving the accessory middle colic artery. All fluorescent lymph nodes were resected. The pathological diagnosis was pT4aN1aM0 stage IIIb. The patient’s postoperative course was uneventful. Adjuvant chemotherapy was administered, and the patient was recurrence-free at 1.5 years after surgery. Conclusions We were able to perform safe and appropriate surgery oncologically, despite abnormal vascular anatomy, due to preoperative identification using 3D-CT and intraoperative navigation using ICG administration.
- Published
- 2021
37. Changes in carnitine levels through induction chemotherapy in head and neck cancer patients as a potential cause of therapy-related malaise
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Hiroki Sato, Akira Shimizu, Tatsuya Ito, Kiyoaki Tsukahara, and Isaku Okamoto
- Subjects
Adult ,Male ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Visual analogue scale ,Gastroenterology ,Malaise ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Carnitine ,Genetics ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Head and neck cancer ,Fatigue ,RC254-282 ,Aged ,Cisplatin ,Free carnitine ,030109 nutrition & dietetics ,business.industry ,Research ,Induction chemotherapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Middle Aged ,medicine.disease ,Oncology ,Docetaxel ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,medicine.symptom ,business ,medicine.drug - Abstract
Background Carnitine is related to malaise, and cisplatin is associated with decreased carnitine. The purpose of this study was to elucidate the effects of one course of induction chemotherapy (IC) for head and neck cancer on blood carnitine levels, focusing on free carnitine (FC). Methods This single-center prospective study investigated 20 patients diagnosed with primary head and neck cancer who underwent IC with cisplatin, docetaxel, and 5-fluorouracil. FC, acylcarnitine (AC), and total carnitine (TC) levels were measured before starting therapy and on Days 7 and 21 after starting IC. In addition, malaise was evaluated before and after therapy using a visual analog scale (VAS). Results All subjects were men and the most common primary cancer site was the hypopharynx (9 patients). FC levels before starting therapy and on Days 7 and 21 were 47.7 ± 2.2 μM/mL, 56.7 ± 2.2 μM/mL, and 41.1 ± 1.9 μM/mL, respectively. Compared with the baseline before starting therapy, FC had significantly decreased on Day 21 (p = 0.007). AC levels before starting therapy and on Days 7 and 21 were 12.5 ± 1.2 μM/mL, 13.6 ± 1.4 μM/mL, and 10.7 ± 0.7 μM/mL, respectively. TC levels before starting therapy and on Days 7 and 21 were 60.2 ± 2.5 μM/mL, 70.2 ± 3.3 μM/mL, and 51.7 ± 2.3 μM/mL, respectively. No significant differences in AC, TC or VAS were seen before the start of therapy and on Day 21. Conclusions After IC, a latent decrease in FC occurred without any absolute deficiency or subjective malaise.
- Published
- 2021
38. Extraction behaviors of platinum group metals in simulated high-level liquid waste by a hydrophobic ionic liquid bearing an amino moiety
- Author
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Haruka Oosugi, Tatsuya Ito, Kiyoshi Kanie, Hao Wu, Tadayuki Takahashi, and Seong Yun Kim
- Subjects
Aqueous solution ,020209 energy ,Metal ions in aqueous solution ,Inorganic chemistry ,Extraction (chemistry) ,Kinetics ,02 engineering and technology ,Simulated high-level liquid waste ,Platinum group ,Ionic liquid ,Platinum group metals ,lcsh:TK9001-9401 ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Nuclear Energy and Engineering ,chemistry ,Nitric acid ,0202 electrical engineering, electronic engineering, information engineering ,Moiety ,lcsh:Nuclear engineering. Atomic power - Abstract
A hydrophobic ionic liquid including an amino moiety ([DiOcAPmim][NTf2]) was synthesized. Its extraction behaviors towards Pd(II), Ru(III), Rh(III) were investigated in nitric acid aqueous solution as a function of contact time, effect of concentration of nitric acid, effect of temperature, and effect of co-existing metal ions. The extraction kinetics of Pd(II) was fairly fast and extraction equilibrium can be attained within only 5 min under the [HNO3] = 2.05 M. When [HNO3]< 1 M, the extraction percentage of Pd(II), Ru(III), Rh(III) were all above 80%. When [HNO3] reached 2 M, all of the extraction percentage decreased and in an order of Pd(II)>Ru(III)>Rh(III). When [HNO3]> 2 M, the extraction performance gradually recovered. The effect of temperature can slightly affect the extraction performance of Pd(II). Furthermore, in simulated high-level liquid waste, [DiOcAPmim][NTf2] showed a better preference towards Pd(II) under the interference of various other co-existing metal ions.
- Published
- 2021
39. A Case Report of a Pathological Complete Response to Hilar Cholangiocarcinoma Due to Prior Treatment for Synchronous Gastric Cancer
- Author
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Hiroshi Yamaguchi, Hiroki Fujino, Hiroyuki Ohnuma, Makoto Yoshida, Takayuki Nobuoka, Ichiro Takemasa, Taro Sugawara, Eiji Yoshida, Minoru Nagayama, Ayumi Kanazawa, Masafumi Imamura, Tatsuya Ito, Junji Kato, Yasutoshi Kimura, and Shintaro Sugita
- Subjects
Oncology ,Prior treatment ,medicine.medical_specialty ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,Cancer ,Surgery ,medicine.disease ,business ,Pathological ,Complete response - Published
- 2021
40. A multicenter, phase II study of R-THP-COP therapy for elderly patients with newly diagnosed, advanced-stage, indolent B-cell lymphoma
- Author
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Takaaki Ono, Tomomitsu Hotta, Kazuma Ohyashiki, Kazuhito Yamamoto, Kaneyuki Ohbayashi, Tatsuya Ito, Koichi Miyamura, Yoshitoyo Kagami, Kazunori Ohnishi, Michinori Ogura, Mitsune Tanimoto, Kensuke Naito, Kiyoshi Ando, Ken Ohmachi, Kunihiro Tsukasaki, Tomohiro Kinoshita, and Takayo Suzuki
- Subjects
Male ,medicine.medical_specialty ,Lymphoma, B-Cell ,Prednisolone ,Follicular lymphoma ,Phases of clinical research ,Neutropenia ,elderly patients ,Gastroenterology ,Indolent B-cell lymphoma ,Internal medicine ,R-THP-COP ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,B-cell lymphoma ,Cyclophosphamide ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Performance status ,business.industry ,Combination chemotherapy ,General Medicine ,medicine.disease ,Treatment Outcome ,Doxorubicin ,Vincristine ,Original Article ,Mantle cell lymphoma ,Rituximab ,Neoplasm Grading ,business ,medicine.drug - Abstract
The optimal combined chemotherapy regimen with rituximab has yet to be established for elderly patients with advanced-stage indolent B-cell lymphoma (B-NHL). A multicenter study was performed to evaluate the efficacy and toxicity of R-THP-COP therapy in elderly patients (aged 70–79 years) with newly diagnosed advanced-stage indolent B-NHL using the complete response rate (%CR) as the primary endpoint. Patients with newly diagnosed, clinical stage III/IV, indolent B-NHL, aged 70–79 years, with a performance status of 0–2 were eligible for this study. R-THP-COP consists of 375 mg/m2 of rituximab, 50 mg/m2 of pirarubicin, 750 mg/m2 of cyclophosphamide, 1.4 mg/m2 of vincristine, and 100 mg/day of oral prednisolone for 5 days. This study was discontinued due to poor accrual after the enrollment of 18 patients, although the planned sample size was 40 patients. The numbers of patients with follicular lymphoma, mucosa-associated lymphoid tissue lymphoma, and mantle cell lymphoma were 16, 1, and 1, respectively. The median age was 73 (range, 70 to 79) years. The %CR including unconfirmed CR was 45% (95% confidence interval: 25-66%) and the overall response rate was 72%. The estimated 5-year overall survival and progression-free survival rates were 55% and 28%, respectively. The major toxicity observed was grade 4 neutropenia (94%). Grade 4 non-hematological toxicities were not observed and no patients developed grade 3/4 cardiac toxicities. This phase II study provides useful information regarding the efficacy and toxicity of R-THP-COP therapy for patients aged 70 years or older with newly diagnosed, advanced-stage, indolent B-NHL, although the sample size was small.
- Published
- 2021
41. Effect of Rikkunshito, a Traditional Japanese Herbal Medicine, on Delayed Gastric Emptying and Oral Dietary Intake After Pancreaticoduodenectomy: A Prospective, Randomized, Single-Center, Open-Labeled Study
- Author
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Emi Akizuki, Hiroshi Yamaguchi, Tsuyoshi Kono, Kenji Okita, Ichiro Takemasa, Toshihiko Nishidate, Masafumi Imamura, Toru Mizuguchi, Yasutoshi Kimura, Koichi Hirata, Tatsuya Ito, Daisuke Kyuno, Takayuki Nobuoka, Akina Kimura, and Minoru Nagayama
- Subjects
medicine.medical_specialty ,delayed gastric emptying ,Single Center ,leptin ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Clinical endpoint ,Adverse effect ,Clinical and Experimental Gastroenterology ,Gastric emptying ,business.industry ,Incidence (epidemiology) ,Leptin ,Perioperative ,Clinical Trial Report ,Rikkunshito ,ghrelin ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Ghrelin ,pancreaticoduodenectomy ,business - Abstract
Hiroshi Yamaguchi,1 Yasutoshi Kimura,1 Masafumi Imamura,1 Minoru Nagayama,1 Tatsuya Ito,1 Daisuke Kyuno,1 Tsuyoshi Kono,1 Akina Kimura,1 Emi Akizuki,1 Toshihiko Nishidate,1 Kenji Okita,1 Takayuki Nobuoka,1 Toru Mizuguchi,1,2 Koichi Hirata,3 Ichiro Takemasa1 1Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, School of Medicine, Sapporo, Japan; 2Department of Nursing and Surgical Science, Sapporo Medical University School of Health Science, Sapporo, Japan; 3Department of Surgery, JR Sapporo Hospital, Sapporo, JapanCorrespondence: Hiroshi YamaguchiDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, South 1, West 16, Sapporo 060-8543, JapanTel +81 11-611-2111 Ext 32810Fax +81 11-613-1678Email hyama@sapmed.ac.jpIntroduction: Delayed gastric emptying (DGE) remains an important problem after pancreaticoduodenectomy (PD). There is a lack of effective treatments for early recovery of oral dietary intake. Rikkunshito (RKT), a Japanese herbal medicine, has been gaining attention as a facilitator of gastric emptying. We evaluated the effects of RKT on DGE after PD.Methods: In this prospective, randomized, open-labeled study, patients were randomly allocated before PD in a 1:1 ratio to the RKT group or the control group that received no additional treatment. The RKT group received 2.5 g of RKT three times daily (7.5 g/day) from postoperative day (POD) 1 to POD 21. The primary endpoint was the incidence of DGE. Secondary endpoints were short-term postoperative outcomes including oral dietary intake volume and perioperative changes in levels of the hormones ghrelin and leptin. Patients were observed until hospital discharge.Results: Twenty-six patients in each group (n = 52) completed the protocol treatment and were included in the analysis set. There were no statistically significant differences in basic characteristics and operative factors. The overall incidence of DGE was not statistically different between the RKT and control groups (30.8% vs 30.8%, p> 0.9999). There were no statistically significant differences in the amount of postoperative oral dietary intake represented by total dietary intake (TDI) up to POD 14 and POD 21, complications, and length of hospital stay. No adverse events related to this study were observed. In the RKT group, total ghrelin and acyl-ghrelin were significantly upregulated and leptin was significantly downregulated earlier than in the control group.Conclusion: RKT treatment from POD 1 to 21 did not reduce the incidence of DGE and had no clinically beneficial effect on short-term postoperative outcomes irrespective of changes in hormone levels.Keywords: delayed gastric emptying, pancreaticoduodenectomy, Rikkunshito, ghrelin, leptin
- Published
- 2020
42. Comparisons of Nonhyperemic Pressure Ratios
- Author
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Mitsuyasu Terashima, Hideaki Ota, Masayasu Nakagawa, Akihiro Hirakawa, Itta Kawamura, Taiji Miyake, Toru Tanigaki, Yoriyasu Suzuki, Masanori Kawasaki, Hiroyuki Omori, Takahiko Suzuki, Hitoshi Matsuo, Takuya Mizukami, Yoshihiro Sobue, Munenori Okubo, Javier Escaned, Hiroki Kamiya, Tetsuo Hirata, Yoshiaki Kawase, Jun Kikuchi, Takeshi Kondo, Kunihiko Tsuchiya, and Tatsuya Ito
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,030204 cardiovascular system & hematology ,Predictive value ,Coronary revascularization ,Confidence interval ,law.invention ,03 medical and health sciences ,surgical procedures, operative ,0302 clinical medicine ,Blood pressure ,Randomized controlled trial ,law ,Internal medicine ,Conventional PCI ,medicine ,Cardiology ,cardiovascular diseases ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Intravascular imaging - Abstract
Objectives The aim of this study was to investigate the accuracy of pre–percutaneous coronary intervention (PCI) predicted nonhyperemic pressure ratios (NHPRs) with actual post-PCI NHPRs and to assess the efficacy of PCI strategy using pre-PCI NHPR pullback. Background Predicting the functional results of PCI is feasible using pre-PCI longitudinal vessel interrogation with the instantaneous wave-free ratio (iFR), a pressure-based, adenosine-free NHPR. However, the reliability of novel NHPRs (resting full-cycle ratio [RFR] and diastolic pressure ratio [dPR]) for this purpose remains uncertain. Methods In this prospective, multicenter, randomized controlled trial, vessels were randomly assigned to receive pre-PCI iFR, RFR, or dPR pullback (50 vessels each). The pre-PCI predicted NHPRs were compared with actual NHPRs after contemporary PCI using intravascular imaging. The number and the total length of treated lesions were compared between NHPR pullback–guided and angiography-guided strategies. Results The predicted NHPRs were strongly correlated with actual NHPRs: iFR, r = 0.83 (95% confidence interval: 0.72 to 0.90; p Conclusions Predicting functional PCI results on the basis of pre-procedural RFR and dPR pullbacks yields similar results to iFR. Compared with an angiography-guided strategy, a pullback–guided PCI strategy with any of the 3 NHPRs reduced the number and the total length of treated lesions. (Study to Examine Correlation Between Predictive Value and Post PCI Value of iFR, RFR and dPR; UMIN000033534 )
- Published
- 2020
43. Accuracy of patient setup positioning using surface‐guided radiotherapy with deformable registration in cases of surface deformation
- Author
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Boriphat, Kadman, Akihiro, Takemura, Tatsuya, Ito, Naoki, Okada, Hironori, Kojima, and Shinichi, Ueda
- Subjects
Radiation ,Phantoms, Imaging ,Radiotherapy Planning, Computer-Assisted ,Brachytherapy ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiotherapy Setup Errors ,Instrumentation ,Patient Positioning ,Radiotherapy, Image-Guided - Abstract
The Catalyst™ HD (C-RAD Positioning AB, Uppsala, Sweden) is surface-guided radiotherapy (SGRT) equipment that adopts a deformable model. The challenge in applying the SGRT system is accurately correcting the setup error using a deformable model when the body of the patient is deformed. This study evaluated the effect of breast deformation on the accuracy of the setup correction of the SGRT system. Physical breast phantoms were used to investigate the relationship between the mean deviation setup error obtained from the SGRT system and the breast deformation. Physical breast phantoms were used to simulate extension and shrinkage deformation (-30 to 30 mm) by changing breast pieces. Three-dimensional (3D) Slicer software was used to evaluate the deformation. The maximum deformations in X, Y, and Z directions were obtained as the differences between the original and deformed breasts. We collected the mean deviation setup error from the SGRT system by replacing the original breast part with the deformed breast part. The mean absolute difference of lateral, longitudinal, vertical, pitch, roll, and yaw, between the rigid and deformable registrations was 2.4 ± 1.7 mm, 1.3 ± 1.2 mm, 6.4 ± 5.2 mm, 2.5° ± 2.5°, 2.2° ± 2.4°, and 1.0° ± 1.0°, respectively. Deformation in the Y direction had the best correlation with the mean deviation translation error (R = 0.949) and rotation error (R = 0.832). As the magnitude of breast deformation increased, both mean deviation setup errors increased, and there was greater error in translation than in rotation. Large deformation of the breast surface affects the setup correction. Deformation in the Y direction most affects translation and rotation errors.
- Published
- 2022
44. Can Non-expert Physicians Use the Japan Narrow-band Imaging Expert Team Classification to Diagnose Colonic Polyps Effectively?
- Author
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Tadashi Yabana, Mayuko Takami, Yuki Hashimoto, Satoshi Hayashi, Tatsuma Nomura, Taishi Temma, Naoko Okuda, Tatsuya Ito, Shinya Sugimoto, Jun Oyamada, and Akira Kamei
- Subjects
colorectal adenoma ,medicine.medical_specialty ,Narrow-band imaging ,medicine.diagnostic_test ,business.industry ,Fecal occult blood ,Colonoscopy ,medicine.disease ,Magnifying colonoscopy ,Colon polyps ,Exact test ,Patient age ,colonoscopy ,medicine ,Mann–Whitney U test ,lcsh:Diseases of the digestive system. Gastroenterology ,Radiology ,Original Research Article ,JNET classification ,lcsh:RC799-869 ,business - Abstract
Objectives: In 2014, the Japan narrow-band imaging expert team (JNET) proposed the first unified colorectal narrow-band imaging magnifying classification system, the JNET classification. The clinical usefulness of this system has been well established in JNET member institutions, but its suitability for use by “non-expert physicians” (physicians with no expertise in the use of JNET classification) remains unclear. This study aimed to examine the clinical usefulness of the JNET classification by “non-expert physicians”. Methods: We retrospectively analyzed 852 consecutive patients who underwent screening colonoscopy following a positive fecal occult blood test between January 2017 and May 2018. Endoscopic results from colon polyp diagnosis by physicians who started using the JNET classification (JNET group) were compared with those of physicians who did not (control group). Mann-Whitney U test and Fisher's exact test were used to compare continuous and categorical variables, respectively. Results: The median patient age was 68 years, and the male-to-female ratio was 1:0.84. When no lesions were found, the median withdrawal time was significantly different between groups (JNET group: 12 min; control group: 15 min; P < 0.01). The number of resected adenomas per colonoscopy was significantly higher in the JNET group (1.7) than in the control group (1.2; P < 0.01). Among the resected lesions, 8.9% in the JNET group and 17% in the control group were non-neoplastic lesions that did not require resection (P < 0.01). Conclusions: Colon polyp diagnosis using the JNET classification can reduce unnecessary resection during magnifying colonoscopy when conducted by “non-expert physicians”.
- Published
- 2020
45. Midterm Clinical Impacts of Biodegradable Polymer Everolimus-Eluting Stents Compared with Durable Polymer Everolimus-Eluting Stents: A 3-Year Propensity-Matched Study
- Author
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Yoriyasu Suzuki, Tatsuya Ito, Takahiro Tokuda, Hiroaki Matsuda, Yusuke Ochiumi, Ai Kagase, and Akira Murata
- Subjects
Male ,Target lesion ,medicine.medical_specialty ,Article Subject ,Polymers ,medicine.medical_treatment ,Coronary Artery Disease ,Percutaneous Coronary Intervention ,Internal medicine ,Absorbable Implants ,medicine ,Clinical endpoint ,Diseases of the circulatory (Cardiovascular) system ,Humans ,Radiology, Nuclear Medicine and imaging ,Cumulative incidence ,Everolimus ,Myocardial infarction ,Propensity Score ,Aged ,Retrospective Studies ,business.industry ,Incidence (epidemiology) ,Percutaneous coronary intervention ,Drug-Eluting Stents ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Treatment Outcome ,RC666-701 ,Propensity score matching ,Clinical Study ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Immunosuppressive Agents - Abstract
Objectives. Our aim was to evaluate the safety and efficacy of biodegradable polymer everolimus-eluting stents (BP-EES) compared with durable polymer everolimus-eluting stents (DP-EES) in midterm. Background. There are few data about midterm clinical outcomes of BP-EES compared with DP-EES. Methods and Results. Between January 2016 and December 2017, 395 consecutive patients were treated with BP-EES and 391 consecutive patients were treated with DP-EES in Nagoya Heart Center. The primary endpoint was a 3-year cumulative incidence of target lesion failure (TLF) defined as cardiac death, target vessel myocardial infarction (MI), and clinical indicated target lesion revascularization (TLR). Moreover, clinical indicated target vessel revascularization (TVR) and definite stent thrombosis (ST) were also evaluated as the secondary endpoints. After propensity score matching, 327 patients were selected in each group. At 3 years, the cumulative incidence of TLF was 4.5% in the BP-EES group versus 6.5% in DP-EES (adjusted HR 0.67 (95% CI 0.33–1.30), log-rank P=0.23). Regarding the individual components of the TLF at 3 years, the cumulative incidence of target vessel MI was significantly lower in BP-EES than in DP-EES (0% versus 1.9%: adjusted HR 0.83 (95% CI 0.71–0.97), log-rank P=0.01), but there was no difference between BP-EES and DP-EES in the incidence of cardiac death and clinically indicated TLR. The cumulative 3-year incidence of definite ST was significantly lower in BP-EES than in DP-EES (0% versus 1.6%, log-rank P=0.02). Conclusions. There were no significant differences of TLF between BP-EES and DP-EES within 3 years. In this study, BP-EES seems to prevent definite ST and be safer than DP-EES in midterm.
- Published
- 2020
46. Prevalence and Clinical Implications of the Mirror and TV Signs in Advanced Alzheimer’s Disease and Dementia with Lewy Bodies
- Author
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Hiroshige Fujishiro, Toshiya Fukui, Hiroko Ohtaki, Momoka Okabe, Tatsuya Ito, Hiroko Suga, Hiroshi Akutagawa, and Yasuhiro Nagahama
- Subjects
medicine.medical_specialty ,misidentification of the mirror image ,Cognitive Neuroscience ,Delusional misidentification syndrome ,delusional misidentification syndrome ,Disease ,lcsh:Geriatrics ,Audiology ,lcsh:RC346-429 ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,medicine ,Cognitive decline ,Cognitive impairment ,lcsh:Neurology. Diseases of the nervous system ,030214 geriatrics ,Dementia with Lewy bodies ,business.industry ,Advanced stage ,lewy body dementia ,Neuropsychology ,sense of self ,alzheimer’s disease ,Alzheimer's disease ,medicine.disease ,Visual Hallucination ,lcsh:RC952-954.6 ,Psychiatry and Mental health ,medicine.symptom ,business ,misidentification of television ,030217 neurology & neurosurgery ,Research Article - Abstract
Objective: To explore the prevalence and clinical implications of the mirror and TV signs in the moderate to advanced stages of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Methods: We retrospectively examined the prevalence of clinical and psychiatric symptoms including the mirror and TV signs in 200 subjects with AD and 200 with DLB and evaluated the relationships among the symptoms. Results: The mirror sign was found in 3.0% of AD and 4.5% of DLB subjects. The TV sign was found in 1.5% of AD and 4.0% of DLB subjects. The prevalence of the mirror and TV signs was not significantly different between the AD and DLB groups. Visual hallucination, visual illusion, misidentification of person, and sleep talking were significantly more frequent in DLB than in AD subjects. The mirror sign was significantly associated with lower Mini-Mental State Examination scores, whereas the TV sign was significantly associated with the misidentification of person. Conclusions: Both the mirror and TV signs were rare even in the moderate to advanced stages of AD and DLB. The mirror sign may be independent from other delusional misidentification syndromes (DMSs). Being associated mainly with global cognitive decline, the mirror sign is unlikely attributed to any specific cognitive impairment or the dysfunction of localized brain areas. In contrast, the TV sign was significantly more often coexistent with the misidentification of person, suggesting that the TV sign may partly share common neuropsychological mechanisms with DMSs.
- Published
- 2020
47. Is complete stone removal for choledocholithiasis always necessary in extremely elderly patients?
- Author
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Tatsuya Ito, Mayuko Takami, Haruka Nakamura, Shinya Sugimoto, Yuki Hashimoto, Hirohisa Hisada, Jun Oyamada, Akira Kamei, Naoko Okuda, Taishi Temma, and Satoshi Hayashi
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,choledocholithiasis ,Significant difference ,Gastroenterology ,Original Articles ,RC799-869 ,Diseases of the digestive system. Gastroenterology ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,plastic stent ,030220 oncology & carcinogenesis ,Overall survival ,Medicine ,030211 gastroenterology & hepatology ,Plastic stent ,Complication rate ,Original Article ,extremely elderly ,Stone removal ,business - Abstract
Background and Aim Endoscopic stone removal has some complications. Although the life expectancy of elderly patients has increased dramatically worldwide, little information is available on the necessity of complete endoscopic stone removal in extremely elderly patients. This study aimed to evaluate the safety and efficacy of complete endoscopic stone removal in extremely elderly patients. Methods All extremely elderly patients (>90 years) who underwent endoscopic stone removal for choledocholithiasis at our hospital between January 2012 and January 2017 were retrospectively evaluated. The included patients were divided into complete stone removal and incomplete stone removal groups. Complication rate, overall survival (OS), and disease‐specific survival (DSS) rates were compared between the two groups. Results Overall, 73 patients were included in this study. The median number of stones was one (range, 0–10) and two (range, 1–12) (P = 0.043), while the median diameter of the largest stones was 9 (range, 0–27) and 14 (range, 5–46) mm (P = 0.001) in the complete and incomplete stone removal groups, respectively. During the follow‐up period, OS was 60% and 39% and DSS was 95% and 97% in the complete and incomplete stone removal groups, respectively. Kaplan–Meier analysis found no significant difference in OS and DSS between the two groups (P = 0.052 and P = 0.646, respectively). Conclusion Complete stone removal might not always be necessary in extremely elderly patients aged ≥90 years., A total of 73 extremely elderly patients (>90 years) who underwent endoscopic stone removal for choledocholithiasis were retrospectively evaluated. The patients were divided into complete stone removal and incomplete stone removal (plastic stent insertion) groups. Kaplan–Meier analysis found no significant difference in overall survival (OS), and disease‐specific survival (DSS) between the two groups.
- Published
- 2020
48. Coupled electronic states in CdTe quantum dot assemblies fabricated by utilizing chemical bonding between ligands
- Author
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Taichi Watanabe, Tatsuya Ito, Kim Hyeon-Deuk, DaeGwi Kim, Hang-Beom Bu, Kunio Shimura, and Yong-Shin Lee
- Subjects
Materials science ,Photoluminescence ,Absorption spectroscopy ,business.industry ,Superlattice ,量子ドット ,Energy conversion efficiency ,Quantum dot ,Quantum resonance ,Cadmium telluride photovoltaics ,Miniband ,Chemical bond ,Thermoelectric effect ,Optoelectronics ,General Materials Science ,business - Abstract
Semiconductor quantum dot superlattices (QDSLs) have attracted much attention as key materials for realizing new optoelectronic devices such as solar cells with high conversion efficiency and thermoelectric elements with high electrical conductivity. To improve the charge transport properties of QDSL-based optoelectronic devices, it is important that the QD structures form minibands, which are the coupled electronic states between QDs. A shorter inter-QD distance and a periodic arrangement of QDs are the essential conditions for the formation of minibands. In this study, we use CdTe QDs capped with short ligands of N-acetyl-l cysteine (NAC) to fabricate three-dimensional QD assemblies by utilizing chemical bonding between NACs. Absorption spectra clearly display the quantum resonance phenomenon originating from the coupling of the wave functions between the adjacent QDs in CdTe QD assemblies. Furthermore, we demonstrate the formation of minibands in CdTe QD assemblies by examining both, the excitation energy dependence of photoluminescence (PL) spectra and the detection energy dependence of PL excitation spectra. The fabrication method of QD assemblies utilizing chemical bonding between NACs can be applied to all QDs capped with NAC as a ligand.
- Published
- 2020
49. Stereolithographic Additive Manufacturing of Fluid Channels Bundles with Graded Aperture Sizes in Thermoacoustic Converters
- Author
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Soshu Kirihara and Tatsuya Ito
- Subjects
Optics ,Materials science ,business.industry ,Aperture ,Converters ,business - Published
- 2020
50. Development of Dried Emulsion/Mannitol Composite Microparticles through a Unique Spray Nozzle for Efficient Delivery of Hydrophilic Anti-tuberculosis Drug against Alveolar Macrophages
- Author
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Tatsuaki Tagami, Tetsuya Ozeki, Takemasa Takii, Ryo Maeda, and Tatsuya Ito
- Subjects
0301 basic medicine ,Drug ,Drug Compounding ,media_common.quotation_subject ,Antitubercular Agents ,Pharmaceutical Science ,Mice ,Surface-Active Agents ,03 medical and health sciences ,Drug Delivery Systems ,0302 clinical medicine ,In vivo ,Administration, Inhalation ,Macrophages, Alveolar ,medicine ,Animals ,Tuberculosis ,Mannitol ,Rats, Wistar ,Microparticle ,Lung ,media_common ,Pharmacology ,Chromatography ,Chemistry ,General Medicine ,Rats ,RAW 264.7 Cells ,030104 developmental biology ,Targeted drug delivery ,030220 oncology & carcinogenesis ,Spray drying ,Emulsion ,Alveolar macrophage ,Nanoparticles ,Emulsions ,Hydrophobic and Hydrophilic Interactions ,medicine.drug - Abstract
As alveolar macrophages are attractive targets for the treatment of tuberculosis, effective methods for delivery to alveolar macrophages are under development. We investigated a pulmonary formulation for the efficient delivery of high water-soluble drugs at high concentration targeting alveolar macrophages. In this study, a surfactant-coated high water-soluble drug complex (SDC, a hydrophobic dried emulsion), which can preferably target alveolar macrophages and be expected to deliver drug at a high concentration, was prepared in the first process. OCT313, a high water-soluble sugar derivative with anti-tuberculosis activity was used. Then, a unique two-solution, mixing-type nozzle was used to prepare the SDC nanoparticles in mannitol (MAN) microparticles (SDC/MAN microparticles) because it was difficult to disperse the SDC nanoparticles in aqueous solution. The single micron size of OCT313-SDC/MAN microparticles contained OCT313-SDC nanoparticles (mean particle size of OCT313-SDC nanoparticles, 277.9 nm; drug contents, 1.31 ± 0.041 wt%). We found that the treatment of SDC/MAN microparticles exhibited significantly higher drug accumulation in macrophage cells (Raw264.7 cells, 7.5-fold, at 4 h after treatment) in vitro and in alveolar macrophages in rats (9.1-fold, at 4 h after treatment) in vivo than that of drug alone. These results suggest that the SDC/MAN microparticle formulation prepared by spray drying through a two-solution mixing-type nozzle provides efficient delivery of a water-soluble drug targeting alveolar macrophages and may be useful for tuberculosis treatment.
- Published
- 2019
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