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2. Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, Matsueda, Kazuhiro, Yoshioka, Masao, Miyahara, Koji, Sakaguchi, Chihiro, Nishimura, Mamoru, Nagahara, Teruya, Mannami, Tomohiko, Takenaka, Ryuta, Oka, Shohei, Inoue, Masafumi, Takimoto, Hidetaka, Inaba, Tomoki, Kobayashi, Sayo, Toyokawa, Tatsuya, Tsugeno, Hirofumi, Suzuki, Seiyuu, Sawada, Sachiko, Tanaka, Shouichi, Tsuzuki, Takao, and Okada, Hiroyuki

Published
2023
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3. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort

Author

Mashimo, Yumi, Ishigooka, Masahiro, Fukase, Kazutoshi, Mizuguchi, Yasuhiko, Suzuki, Haruhisa, Ono, Hiroyuki, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Toya, Yosuke, Nakagawa, Masahiro, Toyonaga, Takashi, Takemura, Kenichi, Hirasawa, Kingo, Matsuda, Mitsuru, Yamamoto, Hironori, Tsuji, Yosuke, Hashimoto, Satoru, Yuki, Maeda, Oyama, Tsuneo, Takenaka, Ryuta, Yamamoto, Yoshinobu, Naito, Yuji, Yamamoto, Katsumi, Kobayashi, Nozomu, Kawahara, Yoshiro, Hirano, Masaaki, Koizumi, Shigeto, Hori, Shinichiro, Tajika, Masahiro, Hikichi, Takuto, Yao, Kenshi, Yokoi, Chizu, Ohnita, Ken, Hisanaga, Yasuhiro, Sumiyoshi, Tetsuya, Kitamura, Shinji, Tanaka, Hisao, Shimoda, Ryo, Shimazu, Taichi, Takizawa, Kohei, Tanabe, Satoshi, Kondo, Hitoshi, Iishi, Hiroyasu, Ninomiya, Motoki, and Oda, Ichiro

Published
2023
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4. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Kanzaki, Hiromitsu, Inoue, Shuntaro, Miyake, Muneaki, Ohmori, Masayasu, Takeuchi, Yoji, Tani, Yasuhiro, Harada, Nobuyuki, Agatsuma, Nobukazu, Okada, Keijirou, Ikenouchi, Maiko, Nakatani, Yasuki, Uenoyama, Yoshito, Yamashita, Yukitaka, Ishikawa, Shigenao, Inaba, Tomoki, Miyahara, Koji, Moritou, Yuki, Nakagawa, Masahiro, Kitae, Hiroaki, Ishida, Tsugitaka, Naito, Yuji, Nishio, Akiyoshi, Shimatani, Masaaki, Kato, Ryo, Taki, Shinya, Mandai, Koichiro, Sanada, Kasumi, Nakase, Kojiro, Nebiki, Hiroko, Saito, Shunsuke, Wakatsuki, Toshiyuki, Nishimura, Naoyuki, Yamasaki, Yasushi, Uedo, Noriya, Akamatsu, Takuji, Kagawa, Tomo, Higashi, Reiji, Dohi, Osamu, Furukawa, Masanori, Takahashi, Yu, Inoue, Takuya, Tanaka, Shouichi, Takenaka, Ryuta, Iguchi, Mikitaka, Kawamura, Takuji, Tsuzuki, Takao, Yamasaki, Tomoaki, Yamashina, Takeshi, Nasu, Junichiro, Mannami, Tomohiko, Yamauchi, Atsushi, Matsueda, Kazuhiro, Aizawa, Shigeyuki, Mitsuhashi, Toshiharu, and Okada, Hiroyuki

Published
2022
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8. Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Miyahara, Koji, Nakagawa, Masahiro, Mouri, Hirokazu, Mizuno, Motowo, Takahashi, Sakuma, Hori, Shinichiro, Nasu, Junichiro, Tsuzuki, Takao, Miyaike, Jiro, Takenaka, Ryuta, Yamauchi, Kenji, Kobayashi, Sayo, Toyokawa, Tatsuya, Inoue, Masafumi, Nishimura, Mamoru, Matsubara, Minoru, Tomoda, Jun, Yamasaki, Yasushi, Tanaka, Takehiro, Shirakawa, Yasuhiro, Kawahara, Yoshiro, Fujiwara, Toshiyoshi, Okada, Hiroyuki, and Okayama Gut Study Group

Subjects
Barrett's adenocarcinoma, lesion, surgery, Barrett Esophagus, endoscopic resection, Esophageal Neoplasms, Japan, short -segment Barrett's esophagus, metachronous, Humans, Adenocarcinoma, Retrospective Studies, long -segment Barrett's esophagus
Abstract

Objective Although Barrett's adenocarcinoma (BA) remains a minor disease in Japan, its incidence has been gradually increasing. We analyzed the characteristics of BA in Japanese populations. Methods We retrospectively reviewed medical records and analyzed the clinicopathological differences between short-segment Barrett's esophagus (SSBE) and long-segment Barrett's esophagus (LSBE), as well as metastasis. Local recurrence and metachronous lesions were analyzed only in patients who underwent endoscopic resection (ER). Patients Consecutive patients who had pathological T1 BAs resected by ER or surgery from January 2003 Results A total of 168 patients were analyzed, including 139 with SSBE and 29 with LSBE. In total, 67% of the SSBE lesions and 32% of the LSBE lesions were located between 0 and 3 o'clock (p=0.0014). No patients who achieved pathological margin-free resection (pR0) and 17% of patients who did not achieve pR0 experienced local recurrence (p=0.0131). None of the patients without lymphovascular involvement, a poorly differentiated component, lesion size of >30 mm, and submucosal invasion of >500 mu m experienced metastasis. The 5-year cumulative incidence rate of metachronous BA after ER was 0% in patients with SSBE and 40% in patients with LSBE (p=0.0005). Conclusion Superficial BA was likely to be detected at the right anterior wall of SSBE in the Japanese population. The risk for metachronous BA after ER was high in Japanese patients with LSBE, as in Western patients.

Published
2022

9. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort

Author

Suzuki, Haruhisa, primary, Ono, Hiroyuki, additional, Hirasawa, Toshiaki, additional, Takeuchi, Yoji, additional, Ishido, Kenji, additional, Hoteya, Shu, additional, Yano, Tomonori, additional, Tanaka, Shinji, additional, Toya, Yosuke, additional, Nakagawa, Masahiro, additional, Toyonaga, Takashi, additional, Takemura, Kenichi, additional, Hirasawa, Kingo, additional, Matsuda, Mitsuru, additional, Yamamoto, Hironori, additional, Tsuji, Yosuke, additional, Hashimoto, Satoru, additional, Yuki, Maeda, additional, Oyama, Tsuneo, additional, Takenaka, Ryuta, additional, Yamamoto, Yoshinobu, additional, Naito, Yuji, additional, Yamamoto, Katsumi, additional, Kobayashi, Nozomu, additional, Kawahara, Yoshiro, additional, Hirano, Masaaki, additional, Koizumi, Shigeto, additional, Hori, Shinichiro, additional, Tajika, Masahiro, additional, Hikichi, Takuto, additional, Yao, Kenshi, additional, Yokoi, Chizu, additional, Ohnita, Ken, additional, Hisanaga, Yasuhiro, additional, Sumiyoshi, Tetsuya, additional, Kitamura, Shinji, additional, Tanaka, Hisao, additional, Shimoda, Ryo, additional, Shimazu, Taichi, additional, Takizawa, Kohei, additional, Tanabe, Satoshi, additional, Kondo, Hitoshi, additional, Iishi, Hiroyasu, additional, Ninomiya, Motoki, additional, Oda, Ichiro, additional, Mashimo, Yumi, additional, Ishigooka, Masahiro, additional, Fukase, Kazutoshi, additional, and Mizuguchi, Yasuhiko, additional

Published
2023
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10. Prospective multicenter study of the efficacy and safety of cold forceps polypectomy for ≤ 6-mm non-ampullary duodenal low-grade adenomas

Author

Kanzaki, Hiromitsu, additional, Horii, Joichiro, additional, Takenaka, Ryuta, additional, Nakagawa, Hiroyuki, additional, Matsueda, Kazuhiro, additional, Tsuzuki, Takao, additional, Kita, Masahide, additional, Yamasaki, Yasushi, additional, Tanaka, Takehiro, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Tomoda, Jun, additional, and Okada, Hiroyuki, additional

Published
2022
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11. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Yamasaki, Yasushi, primary, Uedo, Noriya, additional, Akamatsu, Takuji, additional, Kagawa, Tomo, additional, Higashi, Reiji, additional, Dohi, Osamu, additional, Furukawa, Masanori, additional, Takahashi, Yu, additional, Inoue, Takuya, additional, Tanaka, Shouichi, additional, Takenaka, Ryuta, additional, Iguchi, Mikitaka, additional, Kawamura, Takuji, additional, Tsuzuki, Takao, additional, Yamasaki, Tomoaki, additional, Yamashina, Takeshi, additional, Nasu, Junichiro, additional, Mannami, Tomohiko, additional, Yamauchi, Atsushi, additional, Matsueda, Kazuhiro, additional, Aizawa, Shigeyuki, additional, Mitsuhashi, Toshiharu, additional, Okada, Hiroyuki, additional, Kanzaki, Hiromitsu, additional, Inoue, Shuntaro, additional, Miyake, Muneaki, additional, Ohmori, Masayasu, additional, Takeuchi, Yoji, additional, Tani, Yasuhiro, additional, Harada, Nobuyuki, additional, Agatsuma, Nobukazu, additional, Okada, Keijirou, additional, Ikenouchi, Maiko, additional, Nakatani, Yasuki, additional, Uenoyama, Yoshito, additional, Yamashita, Yukitaka, additional, Ishikawa, Shigenao, additional, Inaba, Tomoki, additional, Miyahara, Koji, additional, Moritou, Yuki, additional, Nakagawa, Masahiro, additional, Kitae, Hiroaki, additional, Ishida, Tsugitaka, additional, Naito, Yuji, additional, Nishio, Akiyoshi, additional, Shimatani, Masaaki, additional, Kato, Ryo, additional, Taki, Shinya, additional, Mandai, Koichiro, additional, Sanada, Kasumi, additional, Nakase, Kojiro, additional, Nebiki, Hiroko, additional, Saito, Shunsuke, additional, Wakatsuki, Toshiyuki, additional, and Nishimura, Naoyuki, additional

Published
2022
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14. Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer

Author

Matsueda, Katsunori, primary, Kanzaki, Hiromitsu, additional, Takenaka, Ryuta, additional, Nakagawa, Masahiro, additional, Matsueda, Kazuhiro, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Toji, Tomohiro, additional, Tanaka, Takehiro, additional, Yagi, Takahito, additional, Fujiwara, Toshiyoshi, additional, and Okada, Hiroyuki, additional

Published
2021
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15. Balloon Enteroscopy-Assisted Endoscopic Retrograde Cholangiopancreatography for the Treatment of Common Bile Duct Stones in Patients with Roux-en-Y Gastrectomy: Outcomes and Factors Affecting Complete Stone Extraction

Author

Obata, Taisuke, primary, Tsutsumi, Koichiro, additional, Kato, Hironari, additional, Ueki, Toru, additional, Miyamoto, Kazuya, additional, Yamazaki, Tatsuhiro, additional, Matsumi, Akihiro, additional, Fujii, Yuki, additional, Matsumoto, Kazuyuki, additional, Horiguchi, Shigeru, additional, Yasugi, Kengo, additional, Ogawa, Tsuneyoshi, additional, Takenaka, Ryuta, additional, and Okada, Hiroyuki, additional

Published
2021
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16. A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma

Author

IWAMURO, MASAYA, OKADA, HIROYUKI, KAWANO, SEIJI, SHIODE, JUNJI, TAKENAKA, RYUTA, IMAGAWA, ATSUSHI, INABA, TOMOKI, SUZUKI, SEIYU, NISHIMURA, MAMORU, MIZUNO, MOTOWO, ARAKI, MASASHI, MANNAMI, TOMOHIKO, UEKI, TORU, KOBASHI, HARUHIKO, FUKATSU, HARUKA, TANAKA, SHOUICHI, OMOTO, AKIYOSHI, KAWAI, YOSHINARI, KITAGAWA, TAKASHI, TOYOKAWA, TATSUYA, TAKATA, KATSUYOSHI, YOSHINO, TADASHI, TAKAKI, AKINOBU, and YAMAMOTO, KAZUHIDE

Published
2015
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17. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, primary, Kanzaki, Hiromitsu, additional, Inoue, Masafumi, additional, Ishiyama, Shuhei, additional, Yamauchi, Kenji, additional, Miyahara, Koji, additional, Toyokawa, Tatsuya, additional, Tsuzuki, Takao, additional, Miyaike, Jiro, additional, Matsubara, Minoru, additional, Takahashi, Sakuma, additional, Nishimura, Mamoru, additional, Takenaka, Ryuta, additional, Yunoki, Naoko, additional, Hori, Shinichiro, additional, Kobayashi, Sayo, additional, Yamasaki, Yasushi, additional, Kawahara, Yoshiro, additional, Ishikawa, Hideki, additional, and Okada, Hiroyuki, additional

Published
2020
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18. Helicobacter pylori heat-shock protein 60 induces inflammatory responses through the Toll-like receptor-triggered pathway in cultured human gastric epithelial cells

Author

Takenaka, Ryuta, Yokota, Kenji, Ayada, Kiyoshi, Mizuno, Motowo, Zhao, Ying, Fujinami, Yoshihito, Lin, Song-Nan, Toyokawa, Tatsuya, Okada, Hiroyuki, Shiratori, Yasushi, and Oguma, Keiji

Subjects
Heat shock proteins -- Research, Helicobacter pylori -- Research, Biological sciences
Abstract

Contact between Helicobacter pylori and gastric epithelial cells results in activation of NF-[kappa]B followed by secretion of interleukin (IL)-8. However, host-cell receptor(s) and their ligands involved in H. pylori-related IL-8 production have yet to be fully defined. In this study, the interaction between Toll-like receptors (TLRs), which are host receptors for pathogens involved in the innate immune response, and heat-shock protein (HSP) 60, an immune-potent antigen of H. pylori, was examined during H. pylori-induced IL-8 secretion in vitro. Recombinant H. pylori HSP60 (rHpHSP60) was prepared and added to cultured KATO III human gastric epithelial cells with or without pre-incubation with mouse monoclonal anti-TLR2 or anti-TLR4 antibodies. IL-8 mRNA expression and IL-8 protein release were analysed by Northern blotting and immunoassay. Involvement of NF-[kappa]B activation was analysed immunocytochemically by anti-NF-[kappa]B p65 antibody and ammonium pyrrolidinedithiocarbamate (PDTC), an inhibitor of NF-[kappa]B-mediated transcriptional activation, rHpHSP60 induced IL-8 mRNA expression and IL-8 secretion in a dose-dependent manner in KATO III cells. Anti-TLR2 antibody inhibited rHpHSP60-induced IL-8 secretion by 75%, and anti-TLR4 antibody inhibited it by 30%. rHpHSP60 induced nuclear translocation of NF-[kappa]B p65, which was inhibited by pretreatment with anti-TLR2 antibody. Treatment with PDTC significantly decreased the secretion of IL-8 induced by rHpHSP60. These findings suggest that H. pylori HSP60 activates NF-[kappa]B and induces IL-8 production through TLR-triggered pathways in gastric epithelial cells. Thus, it is possible that H. pylori HSP60 and TLR interaction in host cells contributes to the development of gastric inflammation caused by H. pylori infection.

Published
2004

19. Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors

Author

Iwamuro, Masaya, primary, Miyahara, Koji, additional, Sakaguchi, Chihiro, additional, Takenaka, Ryuta, additional, Kobayashi, Sayo, additional, Mouri, Hirokazu, additional, Tanaka, Shigetomi, additional, Toyokawa, Tatsuya, additional, Tanaka, Shouichi, additional, Nishimura, Mamoru, additional, Yamauchi, Kenji, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2020
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22. Su1251 – Clinicopathological Features of Sporadic Non-Ampullary Duodenal Adenoma and Carcinoma: A Multicenter Retrospective Observational Study

Author

Matsueda, Katsunori, primary, Kanzaki, Hiromitsu, additional, Matsueda, Kazuhiro, additional, Nasu, Junichiro, additional, Yoshioka, Masao, additional, Nakagawa, Masahiro, additional, Inoue, Masafumi, additional, Inaba, Tomoki, additional, Imagawa, Atsushi, additional, Takatani, Masahiro, additional, Takenaka, Ryuta, additional, Suzuki, Seiyu, additional, Tomoda, Jun, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2019
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23. Importance of Second-look Endoscopy on an Empty Stomach for Finding Gastric Bezoars in Patients with Gastric Ulcers

Author

Iwamuro, Masaya, Tanaka, Shouichi, Moritou, Yuki, Inaba, Tomoki, Higashi, Reiji, Kusumoto, Chiaki, Yunoki, Naoko, Ishikawa, Shin, Okamoto, Yuko, Kawai, Yoshinari, Kitada, Ken-ichi, Takenaka, Ryuta, Toyokawa, Tatsuya, and Okada, Hiroyuki

Subjects
Adult, Aged, 80 and over, Male, Delayed Diagnosis, Adolescent, gastric ulcer, Tomography, X-Ray, digestive, oral, and skin physiology, Stomach, bezoar, Middle Aged, digestive system diseases, phytobezoar, Bezoars, Young Adult, Gastric Emptying, Gastroscopy, foreign bodies, Humans, Female, Stomach Ulcer, Child, Intestinal Obstruction, Aged, Retrospective Studies
Abstract

Most gastric bezoars can be treated with endoscopic fragmentation combined with or without cola dissolution, whereas laparotomy or laparoscopic surgery is generally inevitable for small intestinal bezoars because they cause small bowel obstruction. Therefore, early diagnosis and management of gastric bezoars are necessary to prevent bezoar-induced ileus. To investigate the incidence of overlooked gastric bezoars during the initial esophagogastroduodenoscopy, we retrospectively reviewed the cases of 27 patients diagnosed with gastrointestinal bezoars. The bezoars were diagnosed using esophagogastroduodenoscopy (n=25), abdominal ultrasonography (n=1), and barium follow-through examination (n=1). Bezoars were overlooked in 9/25 patients (36.0%) during the initial endoscopy examination because the bezoars were covered with debris in the stomach. Of the 9 patients, 8 had concomitant gastric ulcers, and the other patient had gastric lymphoma. Although a computed tomography (CT) scan was performed before the second-look endoscopy in 8 of the 9 patients, the bezoars were mistaken as food debris on CT findings and were overlooked in these patients. In conclusion, gastric bezoars may not be discovered during the initial esophagogastroduodenoscopy and CT scan. In cases with debris in the stomach, second-look endoscopy is essential to detect bezoars.

Published
2017

24. Clinical Outcomes of Endoscopic Hemostasis in Marginal Ulcer Bleeding

Author

Yamasaki, Yasushi, Takenaka, Ryuta, Hori, Keisuke, Takemoto, Koji, Kawano, Seiji, Kawahara, Yoshiro, Fujiki, Shigeatsu, and Okada , Hiroyuki

Subjects
Male, upper gastrointestinal bleeding, marginal ulcer, Hemostasis, Endoscopic, Humans, Female, proton-pump inhibitor, Gastrointestinal Hemorrhage, endoscopic hemostasis, Ulcer
Abstract

The usefulness of endoscopy in marginal ulcer bleeding has rarely been studied, and the optimal method for preventing rebleeding is unclear. Here we assessed the efficacy of endoscopy in marginal ulcer bleeding and examined the efficacy of proton pump inhibitors (PPIs) in the prevention of rebleeding. A total of 28 patients with marginal ulcer bleeding (21 men, 7 women; median age 58.5 years) were treated by endoscopy. We analyzed the clinical characteristics, results of endoscopic therapy, characteristics of rebleeding patients, and relation between the use of PPIs and the duration of rebleeding. Sixteen patients had active bleeding. Initial hemostasis was achieved in all patients. There were no procedure-related adverse events. Rebleeding occurred in one patient within the first month and in 7 patients thereafter. There was a significant difference in the rebleeding rate between the patients who received a PPI and those who did not. In a multivariate analysis, the non-use of PPIs was a risk factor for rebleeding (hazard ratio, 6.22). Therapeutic endoscopy is effective in achieving hemostasis from marginal ulcer bleeding. PPIs may prevent rebleeding from marginal ulcers.

Published
2016

26. The characteristics and outcomes of small bowel adenocarcinoma: a multicentre retrospective observational study

Author

Sakae, Hiroyuki, primary, Kanzaki, Hiromitsu, additional, Nasu, Junichiro, additional, Akimoto, Yutaka, additional, Matsueda, Kazuhiro, additional, Yoshioka, Masao, additional, Nakagawa, Masahiro, additional, Hori, Shinichiro, additional, Inoue, Masafumi, additional, Inaba, Tomoki, additional, Imagawa, Atsushi, additional, Takatani, Masahiro, additional, Takenaka, Ryuta, additional, Suzuki, Seiyu, additional, Fujiwara, Toshiyoshi, additional, and Okada, Hiroyuki, additional

Published
2017
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27. Linked color imaging (LCI), a novel image-enhanced endoscopy technology, emphasizes the color of early gastric cancer

Author

Kanzaki, Hiromitsu, additional, Takenaka, Ryuta, additional, Kawahara, Yoshiro, additional, Kawai, Daisuke, additional, Obayashi, Yuka, additional, Baba, Yuki, additional, Sakae, Hiroyuki, additional, Gotoda, Tatsuhiro, additional, Kono, Yoshiyasu, additional, Miura, Ko, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2017
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29. Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of theMALT1gene

Author

Iwamuro, Masaya, primary, Takenaka, Ryuta, additional, Nakagawa, Masahiro, additional, Moritou, Yuki, additional, Saito, Shunsuke, additional, Hori, Shinichiro, additional, Inaba, Tomoki, additional, Kawai, Yoshinari, additional, Toyokawa, Tatsuya, additional, Tanaka, Takehiro, additional, Yoshino, Tadashi, additional, and Okada, Hiroyuki, additional

Published
2017
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30. Comparing reduced-dose sodium phosphate tablets to 2 L of polyethylene glycol: A randomized study

Author

Ako, Soichiro, primary, Takemoto, Koji, additional, Yasutomi, Eriko, additional, Sakaguchi, Chihiro, additional, Murakami, Mayu, additional, Sunami, Tomoko, additional, Oka, Shohei, additional, Kenta, Hamada, additional, Okazaki, Noriko, additional, Baba, Yuki, additional, Yamasaki, Yasushi, additional, Asato, Toshiyuki, additional, Kawai, Daisuke, additional, Takenaka, Ryuta, additional, Tsugeno, Hirohumi, additional, Hiraoka, Sakiko, additional, Kato, Jun, additional, and Fujiki, Shigeatsu, additional

Published
2017
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31. Rapidly Progressed Primary Intestinal Follicular Lymphoma with Elevation of Soluble Interleukin-2 Receptor Levels

Author

Iwamuro, Masaya, Takenaka, Ryuta, Mori, Atsushi, Fujiki, Shigeatsu, Miyake, Takayoshi, Asakura, Shoji, Okada, Hiroyuki, Takata, Katsuyoshi, Yoshino, Tadashi, and Yamamoto, Kazuhide

Subjects
Article Subject, immune system diseases, hemic and lymphatic diseases
Abstract

A 62-year-old Japanese male was diagnosed with primary intestinal follicular lymphoma involving the duodenum, jejunum, and rectum without lymph node involvement. The patient was classified as low risk by the follicular lymphoma international prognostic index (FLIPI) system. Treatment was deferred because he had no symptoms. Eleven months after the diagnosis, his soluble interleukin-2 receptor (sIL-2R) levels had risen from 383 to 617 U/mL. Lymphoma progression involving an enlarged perigastric lymph node was also documented. This report illustrates a case of rapidly progressed intestinal follicular lymphoma, suggesting the possible usefulness of sIL-2R levels as an indicator of lymphoma progression.

Published
2014
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32. Does Helicobacter pylori Exacerbate Gastric Mucosal Injury in Users of Nonsteroidal Anti-Inflammatory Drugs? A Multicenter, Retrospective, Case-Control Study

Author

Kono, Yoshiyasu, primary, Okada, Hiroyuki, additional, Takenaka, Ryuta, additional, Miura, Ko, additional, Kanzaki, Hiromitsu, additional, Hori, Keisuke, additional, Kita, Masahide, additional, Tsuzuki, Takao, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, and Yamamoto, Kazuhide, additional

Published
2016
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33. Colorectal Manifestation of Follicular Lymphoma

Author

Iwamuro, Masaya, primary, Okada, Hiroyuki, additional, Takata, Katsuyoshi, additional, Takenaka, Ryuta, additional, Inaba, Tomoki, additional, Mizuno, Motowo, additional, Kobashi, Haruhiko, additional, Tanaka, Shouichi, additional, Yoshioka, Masao, additional, Kondo, Eisei, additional, Yoshino, Tadashi, additional, and Yamamoto, Kazuhide, additional

Published
2016
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34. Randomized study of lafutidinevslansoprazole in patients with mild gastroesophageal reflux disease

Author

Takenaka, Ryuta, primary, Okada, Hiroyuki, additional, Kawano, Seiji, additional, Komazawa, Yoshinori, additional, Yoshinaga, Fumiya, additional, Nagata, Shinji, additional, Inoue, Masafumi, additional, Komatsu, Hirohisa, additional, Onogawa, Seiji, additional, Kushiyama, Yoshinori, additional, Mukai, Shinichi, additional, Todo, Hiroko, additional, Okanobu, Hideharu, additional, Manabe, Noriaki, additional, Tanaka, Shinji, additional, Haruma, Ken, additional, and Kinoshita, Yoshikazu, additional

Published
2016
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37. Su1797 Prediction of Mortality for Bleeding Peptic Ulcer After Therapeutic Endoscopy - a Multicenter Validation Study

Author

Chiu, Philip W., primary, Wang, Hsiu-Po, additional, Fujishiro, Mitsuhiro, additional, Ng, Enders K., additional, Takenaka, Ryuta, additional, Nagata, Shinji, additional, Imagawa, Atsushi, additional, Kawahara, Yoshiro, additional, Chen, Chieh-Chang, additional, Yung, Man Yee, additional, Chan, Francis K.L., additional, Lau, James Y., additional, and Sung, Joseph J., additional

Published
2012
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39. T1198 A Comparison of the Diagnostic Capability Between Magnetic Resonance Imaging (MRI) With Diffusion Weighted Imaging (DWI) and 18-Fluoro-2-D-Glucose Positron Emission Tomography (FDG-PET/CT) for Pancreaticobiliary Malignancies

Author

Tsugeno, Hirofumi, primary, Nunoue, Tomokazu, additional, Inokuchi, Toshihiro, additional, Seki, Hiroyuki, additional, Kubota, Junichi, additional, Miyoshi, Kenji, additional, Takemoto, Koji, additional, Takenaka, Ryuta, additional, Taira, Akihiko, additional, and Fujiki, Shigeatu, additional

Published
2010
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40. T2062 Comparison of Healing Rate of Artificial Ulcer After Endoscopic Submucosal Dissection in Relation to the Dose of Proton Pump Inhibitor. a Prospective Randomized Controlled Trial

Author

Kawano, Seiji, primary, Okada, Hiroyuki, additional, Hori, Keisuke, additional, Tanioka, Daisuke, additional, Kita, Masahide, additional, Tsuzuki, Takao, additional, Inoue, Masafumi, additional, Yagi, Satoru, additional, Takenaka, Ryuta, additional, Uemura, Masayuki, additional, Kawahara, Yoshiro, additional, and Yamamoto, Kazuhide, additional

Published
2008
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41. Heat shock protein 60 of Helicobacter pylori induces inflammatory responses through the toll-like receptor-triggered pathway in cultured human gastric epithelial cells

Author

Takenaka, Ryuta, primary, Yokota, Kenji, additional, Mizuno, Motowo, additional, Fujinami, Yoshihito, additional, Toyokawa, Tatsuya, additional, Hiraoka, Sakiko, additional, Hori, Shinichiou, additional, Makidono, Chiho, additional, Take, Susumu, additional, Okada, Hiroyuki, additional, Oguma, Keiji, additional, and Shiratori, Yasushi, additional

Published
2003
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42. Decay-accelerating factor as a surface marker for specialized columnar epithelium in Barrett's esophagus

Author

Hiraoka, Sakiko, primary, Mizuno, Motowo, additional, Terada, Ryou, additional, Okazaki, Hiroaki, additional, Hori, Shinichirou, additional, Makidono, Chiho, additional, Toyokawa, Tatsuya, additional, Takenaka, Ryuta, additional, Take, Susumu, additional, Yamato, Kazuhide, additional, Okada, Hiroyuki, additional, and Shiratori, Yasushi, additional

Published
2003
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45. Endoscopic and clinical features of gastric emphysema.

Author

Iwamuro M, Takenaka R, Toyokawa T, Kita M, Tsuzuki T, Yoshioka M, Gotoda T, Okanoue S, Matsubara M, Sakaguchi C, and Otsuka M

Subjects
Male, Female, Humans, Endoscopy, Intubation, Gastrointestinal, Gastric Mucosa pathology, Gastritis pathology, Stomach Neoplasms pathology, Intraabdominal Infections, Emphysema diagnosis, Emphysema pathology
Abstract

Gastric emphysema is characterized by the presence of intramural gas in the stomach without bacterial infection. Due to its rarity, most reports on gastric emphysema have been limited to single-case studies, and this condition's clinical and endoscopic features have not been thoroughly investigated. In this study, we analyzed 45 patients with gastric emphysema from 10 institutions and examined their characteristics, endoscopic features, and outcomes. The mean age at diagnosis of gastric emphysema in our study population (35 males and 10 females) was 68.6 years (range, 14-95 years). The top five underlying conditions associated with gastric emphysema were the placement of a nasogastric tube (26.7%), diabetes mellitus (20.0%), post-percutaneous endoscopic gastrostomy (17.8%), malignant neoplasms (17.8%), and renal failure (15.6%). Among the 45 patients, 42 were managed conservatively with fasting and administration of proton pump inhibitors. Unfortunately, seven patients died within 30 days of diagnosis, and 35 patients experienced favorable recoveries. The resolution of gastric emphysema was confirmed in 30 patients through computed tomography (CT) scans, with a mean duration of 17.1 ± 34.9 days (mean ± standard deviation [SD], range: 1-180 days) from the time of diagnosis to the disappearance of the gastric intramural gas. There were no instances of recurrence. Endoscopic evaluation was possible in 18 patients and revealed that gastric emphysema presented with features such as redness, erosion, coarse mucosa, and ulcers, with fewer mucosal injuries on the anterior wall (72.2%), a clear demarcation between areas of mucosal injury and intact mucosa (61.1%), and predominantly longitudinal mucosal injuries on the stomach folds (50.0%). This study is the first English-language report to analyze endoscopic findings in patients with gastric emphysema., (© 2024. The Author(s).)

Published
2024
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46. Lymphoid Hyperplasia of the Gallbladder Extending to the Bile Duct.

Author

Miyamoto K, Matsumoto K, Matsubara K, Miyake T, Horiguchi S, Takenaka R, Shinoura S, and Fujiki S

Subjects
Female, Humans, Aged, Hyperplasia diagnostic imaging, Hyperplasia surgery, Hyperplasia pathology, Bile Ducts pathology, Abdomen, Gallbladder diagnostic imaging, Gallbladder surgery, Gallbladder pathology, Cholecystectomy, Laparoscopic
Abstract

A 72-year-old woman was referred for the examination of wall thickening of the bile duct and a polyp-like lesion on the gallbladder. The bile duct and gallbladder lesions were observed to be continuous on abdominal ultrasonography. We performed a bile duct biopsy, and pathological findings showed hyperplasia of the lymphoid follicles without malignancy. We considered these two lesions to be the same lesion, and laparoscopic cholecystectomy was performed to make a definite diagnosis. The pathological examination of the resected gallbladder also showed hyperplasia of the lymphoid follicles. We diagnosed the patient with lymphoid hyperplasia of the gallbladder extending to the bile duct.

Published
2023
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47. Erratum: Prospective multicenter study of the efficacy and safety of cold forceps polypectomy for ≤ 6-mm non-ampullary duodenal low-grade adenomas.

Author

Kanzaki H, Horii J, Takenaka R, Nakagawa H, Matsueda K, Tsuzuki T, Kita M, Yamasaki Y, Tanaka T, Iwamuro M, Kawano S, Kawahara Y, Tomoda J, and Okada H

Abstract

[This corrects the article DOI: 10.1055/a-1793-9439.]., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)

Published
2022
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48. A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants.

Author

Ishiguro M, Takenaka R, Ogura K, Hiratsuka A, Takeda H, Kawai D, Tsugeno H, Fujiki S, and Okada H

Subjects
Antimetabolites, Antineoplastic administration & dosage, Contraindications, Drug, Fatal Outcome, Fluorouracil administration & dosage, Humans, Male, Middle Aged, Adenocarcinoma drug therapy, Antimetabolites, Antineoplastic adverse effects, Dihydropyrimidine Dehydrogenase Deficiency diagnosis, Fluorouracil adverse effects, Stomach Neoplasms drug therapy
Abstract

A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2020
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49. Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease.

Author

Takenaka R, Okada H, Kawano S, Komazawa Y, Yoshinaga F, Nagata S, Inoue M, Komatsu H, Onogawa S, Kushiyama Y, Mukai S, Todo H, Okanobu H, Manabe N, Tanaka S, Haruma K, and Kinoshita Y

Subjects
Acetamides administration & dosage, Acetamides adverse effects, Adult, Aged, Aged, 80 and over, Female, Histamine H2 Antagonists administration & dosage, Histamine H2 Antagonists adverse effects, Histamine H2 Antagonists therapeutic use, Humans, Japan, Lansoprazole administration & dosage, Lansoprazole adverse effects, Male, Middle Aged, Piperidines administration & dosage, Piperidines adverse effects, Proton Pump Inhibitors administration & dosage, Proton Pump Inhibitors adverse effects, Proton Pump Inhibitors therapeutic use, Pyridines administration & dosage, Pyridines adverse effects, Severity of Illness Index, Treatment Outcome, Acetamides therapeutic use, Esophagitis, Peptic drug therapy, Gastroesophageal Reflux drug therapy, Heartburn drug therapy, Lansoprazole therapeutic use, Piperidines therapeutic use, Pyridines therapeutic use
Abstract

Aim: To compare the clinical efficacy of the second-generation H2RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease (GERD)., Methods: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis (according to the Los Angeles classification) were randomized to receive lafutidine (10 mg, twice daily) or lansoprazole (30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale (GSRS), and the satisfaction score., Results: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment (P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group (P = 0.0068 and P = 0.0048, respectively)., Conclusion: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD.

Published
2016
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50. Tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening.

Author

Yamasaki Y, Takenaka R, Hori K, Takemoto K, Kawano S, Kawahara Y, Okada H, Fujiki S, and Yamamoto K

Subjects
Aged, Biopsy, Chest Pain etiology, Early Detection of Cancer adverse effects, Esophagoscopy adverse effects, Female, Heartburn etiology, Humans, Japan, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Time Factors, Coloring Agents adverse effects, Early Detection of Cancer methods, Esophageal Neoplasms pathology, Esophagoscopy methods, Iodides adverse effects, Narrow Band Imaging adverse effects
Abstract

Aim: To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol chromoendoscopy., Methods: We prospectively enrolled and analyzed 51 patients who were at high risk for esophageal cancer. All patients were divided into two groups: a magnifying narrow band imaging group, and a lugol chromoendoscopy group, for comparison of adverse symptoms. Esophageal cancer screening was performed on withdrawal of the endoscope. The primary endpoint was a score on a visual analogue scale for heartburn after the examination. The secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations, change in vital signs, total procedure time, and esophageal observation time., Results: The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group (P = 0.004, 0.024, respectively, ANOVA for repeated measures). The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy group. There was no significant difference between the two groups with respect to other vital sign. The total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group (450 ± 116 vs 565 ± 174, P = 0.004, 44 ± 26 vs 151 ± 72, P < 0.001, respectively)., Conclusion: Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy. Narrow band imaging endoscopy is useful and suitable for esophageal cancer screening periodically.

Published
2015
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