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371 results on '"Takehara, Kazuhiko"'

1. GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Author

Ishikawa, Yuki, Tanaka, Nao, Asano, Yoshihide, Kodera, Masanari, Shirai, Yuichiro, Akahoshi, Mitsuteru, Hasegawa, Minoru, Matsushita, Takashi, Saito, Kazuyoshi, Motegi, Sei-ichiro, Yoshifuji, Hajime, Yoshizaki, Ayumi, Kohmoto, Tomohiro, Takagi, Kae, Oka, Akira, Kanda, Miho, Tanaka, Yoshihito, Ito, Yumi, Nakano, Kazuhisa, Kasamatsu, Hiroshi, Utsunomiya, Akira, Sekiguchi, Akiko, Niiro, Hiroaki, Jinnin, Masatoshi, Makino, Katsunari, Makino, Takamitsu, Ihn, Hironobu, Yamamoto, Motohisa, Suzuki, Chisako, Takahashi, Hiroki, Nishida, Emi, Morita, Akimichi, Yamamoto, Toshiyuki, Fujimoto, Manabu, Kondo, Yuya, Goto, Daisuke, Sumida, Takayuki, Ayuzawa, Naho, Yanagida, Hidetoshi, Horita, Tetsuya, Atsumi, Tatsuya, Endo, Hirahito, Shima, Yoshihito, Kumanogoh, Atsushi, Hirata, Jun, Otomo, Nao, Suetsugu, Hiroyuki, Koike, Yoshinao, Tomizuka, Kohei, Yoshino, Soichiro, Liu, Xiaoxi, Ito, Shuji, Hikino, Keiko, Suzuki, Akari, Momozawa, Yukihide, Ikegawa, Shiro, Tanaka, Yoshiya, Ishikawa, Osamu, Takehara, Kazuhiko, Torii, Takeshi, Sato, Shinichi, Okada, Yukinori, Mimori, Tsuneyo, Matsuda, Fumihiko, Matsuda, Koichi, Amariuta, Tiffany, Imoto, Issei, Matsuo, Keitaro, Kuwana, Masataka, Kawaguchi, Yasushi, Ohmura, Koichiro, and Terao, Chikashi

Published
2024
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2. Perspective to precision medicine in scleroderma

Author

Komura, Kazuhiro, primary, Yanaba, Koichi, additional, Bouaziz, Jean-David, additional, Yoshizaki, Ayumi, additional, Hasegawa, Minoru, additional, Varga, John, additional, Takehara, Kazuhiko, additional, and Matsushita, Takashi, additional

Published
2024
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4. RXRB Is an MHC-Encoded Susceptibility Gene Associated with Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis

Author

Oka, Akira, Asano, Yoshihide, Hasegawa, Minoru, Fujimoto, Manabu, Ishikawa, Osamu, Kuwana, Masataka, Kawaguchi, Yasushi, Yamamoto, Toshiyuki, Takahashi, Hiroki, Goto, Daisuke, Endo, Hirahito, Jinnin, Masatoshi, Mano, Shuhei, Hosomichi, Kazuyoshi, Mabuchi, Tomotaka, Ueda, Mahoko Takahashi, Nakagawa, So, Beck, Stephan, Bahram, Seiamak, Takehara, Kazuhiko, Sato, Shinichi, and Ihn, Hironobu

Published
2017
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6. Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population

Author

Yokoyama, Nozomi, Kawasaki, Aya, Matsushita, Takashi, Furukawa, Hiroshi, Kondo, Yuya, Hirano, Fumio, Sada, Ken-ei, Matsumoto, Isao, Kusaoi, Makio, Amano, Hirofumi, Nagaoka, Shouhei, Setoguchi, Keigo, Nagai, Tatsuo, Shimada, Kota, Sugii, Shoji, Hashimoto, Atsushi, Matsui, Toshihiro, Okamoto, Akira, Chiba, Noriyuki, Suematsu, Eiichi, Ohno, Shigeru, Katayama, Masao, Migita, Kiyoshi, Kono, Hajime, Hasegawa, Minoru, Kobayashi, Shigeto, Yamada, Hidehiro, Nagasaka, Kenji, Sugihara, Takahiko, Yamagata, Kunihiro, Ozaki, Shoichi, Tamura, Naoto, Takasaki, Yoshinari, Hashimoto, Hiroshi, Makino, Hirofumi, Arimura, Yoshihiro, Harigai, Masayoshi, Sato, Shinichi, Sumida, Takayuki, Tohma, Shigeto, Takehara, Kazuhiko, and Tsuchiya, Naoyuki

Published
2019
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13. Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud’s phenomenon

Author

Yang, Lingli, Fujimoto, Minoru, Murota, Hiroyuki, Serada, Satoshi, Fujimoto, Manabu, Honda, Hiromi, Yamada, Kohji, Suzuki, Katsuya, Nishikawa, Ayumi, Hosono, Yuji, Yoneda, Yoshihiro, Takehara, Kazuhiko, Imura, Yoshitaka, Mimori, Tsuneyo, Takeuchi, Tsutomu, Katayama, Ichiro, and Naka, Tetsuji

Published
2015
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17. Tocilizumab in systemic sclerosis:a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Khanna, Dinesh, Lin, Celia J.F., Furst, Daniel E., Goldin, Jonathan, Kim, Grace, Kuwana, Masataka, Allanore, Yannick, Matucci-Cerinic, Marco, Distler, Oliver, Shima, Yoshihito, van Laar, Jacob M., Spotswood, Helen, Wagner, Bridget, Siegel, Jeffrey, Jahreis, Angelika, Denton, Christopher P., Lucero, Eleonora, Pons-Estel, Bernardo, Rivero, Mariano, Tate, Guillermo, Smith, Vanessa, De Langhe, Ellen, Rashkov, Rasho, Batalov, Anastas, Goranov, Ivan, Stoilov, Rumen, Dunne, James, Johnson, Sindhu R., Pope, Janet E., Martinović Kaliterna, Dušanka, Mogensen, Mette, Olesen, Anne Braae, Henes, Joerg Christoph, Müller-Ladner, Ulf, Riemekasten, Gabriela, Skapenko, Alla, Vlachoyiannopoulos, Panayiotis, Kiss, Emese, Minier, Tünde, Beretta, Lorenzo, Gremese, Elisa, Valentini, Gabriele, Asano, Yoshihide, Atsumi, Tatsuya, Ihn, Hironobu, Ishii, Tomonori, Ishikawa, Osamu, Takahashi, Hiroki, Takehara, Kazuhiko, Tanaka, Yoshiya, Yamasaki, Yoshioki, Bukauskiene, Loreta, Butrimiene, Irena, Medrano Ramirez, Gabriel, Ramos-Remus, Cesar, Sofia Rodriguez Reyna, Tatiana, de Vries-Bouwstra, Jeska, Batko, Bogdan, Jeka, Slawomir, Kucharz, Eugeniusz, Majdan, Maria, Olesinska, Marzena, Smolenska, Zaneta, Alves, Jose, Santos, Maria, Mihai, Carmen Marina, Rednic, Simona, Castellvi Barranco, Ivan, Lopez Longo, Francisco Javier, Simeon Aznar, Carmen, Carreira, Patricia, Walker, Ulrich A., Derrett-Smith, Emma, Griffiths, Bridget, McKay, Neil, Aelion, Jacob, Borofsky, Michael, Fleischmann, Roy, Forstot, Joseph Z., Kafaja, Suzanne, Khan, M. Faisal, Kohen, Michael D., Martin, Richard W., Mendoza-Ballesteros, Fabian, Nami, Alireza, Pang, Shirley, Rios, Grissel, Simms, Robert, Sullivan, Keith Michael, Steen, Virginia D., Khanna, Dinesh, Lin, Celia J.F., Furst, Daniel E., Goldin, Jonathan, Kim, Grace, Kuwana, Masataka, Allanore, Yannick, Matucci-Cerinic, Marco, Distler, Oliver, Shima, Yoshihito, van Laar, Jacob M., Spotswood, Helen, Wagner, Bridget, Siegel, Jeffrey, Jahreis, Angelika, Denton, Christopher P., Lucero, Eleonora, Pons-Estel, Bernardo, Rivero, Mariano, Tate, Guillermo, Smith, Vanessa, De Langhe, Ellen, Rashkov, Rasho, Batalov, Anastas, Goranov, Ivan, Stoilov, Rumen, Dunne, James, Johnson, Sindhu R., Pope, Janet E., Martinović Kaliterna, Dušanka, Mogensen, Mette, Olesen, Anne Braae, Henes, Joerg Christoph, Müller-Ladner, Ulf, Riemekasten, Gabriela, Skapenko, Alla, Vlachoyiannopoulos, Panayiotis, Kiss, Emese, Minier, Tünde, Beretta, Lorenzo, Gremese, Elisa, Valentini, Gabriele, Asano, Yoshihide, Atsumi, Tatsuya, Ihn, Hironobu, Ishii, Tomonori, Ishikawa, Osamu, Takahashi, Hiroki, Takehara, Kazuhiko, Tanaka, Yoshiya, Yamasaki, Yoshioki, Bukauskiene, Loreta, Butrimiene, Irena, Medrano Ramirez, Gabriel, Ramos-Remus, Cesar, Sofia Rodriguez Reyna, Tatiana, de Vries-Bouwstra, Jeska, Batko, Bogdan, Jeka, Slawomir, Kucharz, Eugeniusz, Majdan, Maria, Olesinska, Marzena, Smolenska, Zaneta, Alves, Jose, Santos, Maria, Mihai, Carmen Marina, Rednic, Simona, Castellvi Barranco, Ivan, Lopez Longo, Francisco Javier, Simeon Aznar, Carmen, Carreira, Patricia, Walker, Ulrich A., Derrett-Smith, Emma, Griffiths, Bridget, McKay, Neil, Aelion, Jacob, Borofsky, Michael, Fleischmann, Roy, Forstot, Joseph Z., Kafaja, Suzanne, Khan, M. Faisal, Kohen, Michael D., Martin, Richard W., Mendoza-Ballesteros, Fabian, Nami, Alireza, Pang, Shirley, Rios, Grissel, Simms, Robert, Sullivan, Keith Michael, and Steen, Virginia D.

Abstract

Background: A phase 2 trial of tocilizumab showed preliminary evidence of efficacy in systemic sclerosis. We assessed skin fibrosis and systemic sclerosis-associated interstitial lung disease (SSc-ILD) in a phase 3 trial to investigate the safety and efficacy of tocilizumab, an anti-interleukin-6 receptor antibody, in the treatment of systemic sclerosis. Methods: In this multicentre, randomised, double-blind, placebo-controlled, phase 3 trial, participants were recruited from 75 sites in 20 countries across Europe, North America, Latin America, and Japan. Adults with diffuse cutaneous systemic sclerosis for 60 months or less and a modified Rodnan skin score (mRSS) of 10–35 at screening were randomly assigned (1:1) with a voice-web-response system to receive subcutaneous tocilizumab 162 mg or placebo weekly for 48 weeks, stratified by IL-6 levels; participants and investigators were masked to treatment group. The primary endpoint was the difference in change from baseline to week 48 in mRSS. Percentage of predicted forced vital capacity (FVC% predicted) at week 48, time to treatment failure, and patient-reported and physician-reported outcomes were secondary endpoints. This trial is registered with ClinicalTrials.gov (number NCT02453256) and is closed to accrual. Findings: Between Nov 20, 2015, and Feb 14, 2017, 210 individuals were randomly assigned to receive tocilizumab (n=104) or placebo (n=106). In the intention-to-treat population, least squares mean [LSM] change from baseline to week 48 in mRSS was −6·14 for tocilizumab and −4·41 for placebo (adjusted difference −1·73 [95% CI −3·78 to 0·32]; p=0·10). The shift in distribution of change from baseline in FVC% predicted at week 48 favoured tocilizumab (van Elteren nominal p=0·002 vs placebo), with a difference in LSM of 4·2 (95% CI 2·0–6·4; nominal p=0·0002), as did time to treatment failure (hazard ratio 0·63 [95% CI 0·37–1·06]; nominal p=0·08). Change in LSM from baseline to week 48 in Health Assessment Ques

Published
2020

24. Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins

Author

Fujimoto, Manabu, Hamaguchi, Yasuhito, Kaji, Kenzo, Matsushita, Takashi, Ichimura, Yuki, Kodera, Masanari, Ishiguro, Naoko, Ueda-Hayakawa, Ikuko, Asano, Yoshihide, Ogawa, Fumihide, Fujikawa, Keita, Miyagi, Takuya, Mabuchi, Eriko, Hirose, Kenji, Akimoto, Narihiro, Hatta, Naohito, Tsutsui, Kiyohiro, Higashi, Akira, Igarashi, Atsuyuki, Seishima, Mariko, Hasegawa, Minoru, and Takehara, Kazuhiko

Published
2012
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25. Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study

Author

Hasegawa, Minoru, Asano, Yoshihide, Endo, Hirahito, Fujimoto, Manabu, Goto, Daisuke, Ihn, Hironobu, Inoue, Katsumi, Ishikawa, Osamu, Kawaguchi, Yasushi, Kuwana, Masataka, Muro, Yoshinao, Ogawa, Fumihide, Sasaki, Tetsuo, Takahashi, Hiroki, Tanaka, Sumiaki, Takehara, Kazuhiko, and Sato, Shinichi

Published
2012
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28. Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis

Author

Yamashita, Keita, primary, Kawasaki, Aya, additional, Matsushita, Takashi, additional, Furukawa, Hiroshi, additional, Kondo, Yuya, additional, Okiyama, Naoko, additional, Nagaoka, Shouhei, additional, Shimada, Kota, additional, Sugii, Shoji, additional, Katayama, Masao, additional, Hirohata, Shunsei, additional, Okamoto, Akira, additional, Chiba, Noriyuki, additional, Suematsu, Eiichi, additional, Setoguchi, Keigo, additional, Migita, Kiyoshi, additional, Sumida, Takayuki, additional, Tohma, Shigeto, additional, Hamaguchi, Yasuhito, additional, Hasegawa, Minoru, additional, Sato, Shinichi, additional, Kawaguchi, Yasushi, additional, Takehara, Kazuhiko, additional, and Tsuchiya, Naoyuki, additional

Published
2020
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