37 results on '"Tait, E."'
Search Results
2. New Insights on Subsurface Geology and the San Andreas Fault at Loma Prieta, Central California
- Author
-
Gary S. Fuis, Rufus D. Catchings, Daniel S. Scheirer, Klaus Bauer, Mark Goldman, Tait E. Earney, Guoqing Lin, and Edward Zhang
- Subjects
Geophysics ,Geochemistry and Petrology - Abstract
The 1989 Mw 6.9 Loma Prieta earthquake is the first major event to occur along the San Andreas fault (SAF) zone in central California since the 1906 M 7.9 San Francisco earthquake. Given the complexity of this event, uncertainty has persisted as to whether this earthquake ruptured the SAF itself or a secondary fault. Recent work on the SAF in the Coachella Valley in southern California has revealed similar complexity, arising from a nonplanar, nonvertical fault geometry, and has led us to reexamine the Loma Prieta event. We have compiled data sets and data analyses in the vicinity of the Loma Prieta earthquake, including the 3D seismic velocity model and aftershock relocations of Lin and Thurber (2012), potential field data collected by the U.S. Geological Survey following the earthquake, and seismic refraction and reflection data from the 1991 profile of Catchings et al. (2004). The velocity model and aftershock relocations of Lin and Thurber (2012) reveal a geometry for the SAF that appears similar to that in the Coachella Valley (although rotated 180°): at Loma Prieta the fault dips steeply near the surface and curves with depth to join the moderately southwest-dipping main rupture below 6 km depth, itself also nonplanar. The SAF is a clear velocity boundary, with higher velocities on the northeast, attributable to Mesozoic accretionary and other rocks, and lower velocities on the southwest, attributable to Cenozoic sedimentary and volcanic rocks of the La Honda block. Rocks of the La Honda block have been offset right-laterally hundreds of kilometers from similar rocks in the southern San Joaquin Valley and vicinity, providing evidence that the curved northeast fault boundary of this block is the plate boundary. Thus, we interpret that the Loma Prieta earthquake occurred on the SAF and not on a secondary fault.
- Published
- 2022
- Full Text
- View/download PDF
3. Biostratigraphical Dating of the Early History of the South Atlantic Ocean
- Author
-
Reyment, R. A. and Tait, E. A.
- Published
- 1972
4. A conceptual framework for Servitisation of the manufacturing companies to deliver Product–Service Systems solutions: A study case of the Indonesian Motorcycle Industry
- Author
-
Dewi, D R S, primary, Pittayachawan, S, additional, and Tait, E, additional
- Published
- 2020
- Full Text
- View/download PDF
5. Factors Affecting the Production and Usage of Pesticides in the U.K
- Author
-
Tait, E. J.
- Subjects
338.1 - Published
- 1976
6. CUMULATIVE SLIP ESTIMATES ALONG THE EASTERN MARGIN OF THE EASTERN CALIFORNIA SHEAR ZONE, CALIFORNIA
- Author
-
Tait E. Earney, Victoria E. Langenheim, David Okaya, Branden Dean, Kevin L. Mickus, and Keith A. Howard
- Subjects
Slip (materials science) ,Shear zone ,Geology ,Seismology - Published
- 2020
- Full Text
- View/download PDF
7. NEW GEOPHYSICAL OBSERVATIONS ALONG THE KLAMATH-BLUE MOUNTAINS LINEAMENT AND WALLULA FAULT ZONE, NE OREGON AND SE WASHINGTON
- Author
-
Kelsey Wetzel, Scott E.K. Bennett, Tait E. Earney, Lydia M. Staisch, and Richard J. Blakely
- Subjects
Lineament ,Geomorphology ,Geology - Published
- 2019
- Full Text
- View/download PDF
8. Cervical Carcinoma In Young Women
- Author
-
Tait, E. Ann
- Published
- 1973
9. A CASE STUDY OF MEDICAL GEOLOGY: INVESTIGATION OF THE OCCURRENCE OF ERIONITE AND POTENTIAL ENRICHMENT ZONES AT REVA GAP IN HARDING COUNTY, SD
- Author
-
Zeynep Baran and Tait E. Earney
- Subjects
chemistry.chemical_compound ,Medical geology ,Geography ,chemistry ,Erionite ,Archaeology ,Cartography - Published
- 2016
- Full Text
- View/download PDF
10. New Radicals? Digital Political Engagement in Post-Referendum Scotland. Interim Report
- Author
-
McLaverty, P., MacLeod, I., Tait, E., Baxter, G., Göker, A., and Heron, M.
- Published
- 2015
11. New Radicals: Digital Political Engagement in Post-Referendum Scotland. Final Report
- Author
-
McLaverty, P., Baxter, G., MacLeod, I., Tait, E., Göker, A., and Heron, M.
- Published
- 2015
12. Cultural resilience: The production of rural community heritage, digital archives and the role of volunteers
- Author
-
Beel, DE, Wallace, CD, Webster, G, Nguyen, H, Tait, E, Macleod, M, Mellish, C, Beel, DE, Wallace, CD, Webster, G, Nguyen, H, Tait, E, Macleod, M, and Mellish, C
- Abstract
The following paper addresses a lacuna in the literature relating to the concept of resilience. To date, cultural activity in relation to resilient communities has been given little attention and this paper will highlight how the lens of community heritage activities and the ‘bottom-up’ role of volunteer labour can act as a catalyst for building more resilient communities in rural areas. This develops from rural areas that have strong place identities, formed through the reproduction of traditional cultural practices alongside contemporary influences. These identities are performed and constructed through a varied repertoire of knowledges, histories, and customs. Their on-going production can be central to community identity as they attempt to make visible their own accounts of history and place. Beyond this, community heritage organisations have also begun to have grounded ‘impacts’ that move away from heritage interests alone, often revitalising buildings and providing community services. This will be used to highlight how such cultural heritage activity builds collective resilience. A further trend (in the UK) has been for community heritage groups to digitise collections, due to the perceived transformational effect for community regeneration, the strengthening of community cohesion and the potential socio-economic benefits. In partnership with community heritage groups, the CURIOS (Cultural Repositories and Information Systems) project explores two case studies in rural Scotland asking how community activity, connectivity and digital archives can support interest in local heritage as well as help develop more resilient communities.
- Published
- 2017
13. Community engagement and participation with 3D cultural heritage visualisations. Final Seed Report
- Author
-
Tait, E. and Laing, R.
- Published
- 2014
14. From first base: The sequence of the tip of the X-chromosome of Drosophila melanogaster, a comparison of two sequencing strategies
- Author
-
Benos, P., Gatt, M., Murphy, L., Harris, D., Barrell, B., Ferraz, C., Vidal, S., Brun, C., Demailles, J., Cadieu, E., Dreano, S., Gloux, S., Lelaure, V., Mottier, S., Galibert, F., Borkova, D., Minana, B., Kafatos, F., Bolshakov, S., Siden-Kiamos, I., Papagiannakis, G., Spanos, L., Louis, C., Madueno, E., de Pablos, B., Modolell, J., Peter, A., Schoettler, P., Werner, M., Mourkioti, F., Beinert, N., Dowe, G., Schaefer, U., Jaeckle, H., Bucheton, A., Callister, D., Campbell, L., Henderson, N., McMillan, P., Salles, C., Tait, E., Valenti, P., Saunders, R., Billaud, A., Pachter, L., Glover, D., and Ashburner, M.
- Published
- 2001
15. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies.
- Author
-
Benos, P V, Gatt, M K, Murphy, L, Harris, D, Barrell, B, Ferraz, C, Vidal, S, Brun, C, Demaille, J, Cadieu, E, Dreano, S, Gloux, S, Lelaure, V, Mottier, S, Galibert, F, Borkova, D, Miñana, B, Kafatos, F C, Bolshakov, S, Sidén-Kiamos, I, Papagiannakis, G, Spanos, L, Louis, C, Madueño, E, de Pablos, B, Modolell, J, Peter, A, Schöttler, P, Werner, M, Mourkioti, F, Beinert, N, Dowe, G, Schäfer, U, Jäckle, H, Bucheton, A, Callister, D, Campbell, L, Henderson, N S, McMillan, P J, Salles, C, Tait, E, Valenti, P, Saunders, R D, Billaud, A, Pachter, L, Glover, D M, and Ashburner, M
- Abstract
We present the sequence of a contiguous 2.63 Mb of DNA extending from the tip of the X chromosome of Drosophila melanogaster. Within this sequence, we predict 277 protein coding genes, of which 94 had been sequenced already in the course of studying the biology of their gene products, and examples of 12 different transposable elements. We show that an interval between bands 3A2 and 3C2, believed in the 1970s to show a correlation between the number of bands on the polytene chromosomes and the 20 genes identified by conventional genetics, is predicted to contain 45 genes from its DNA sequence. We have determined the insertion sites of P-elements from 111 mutant lines, about half of which are in a position likely to affect the expression of novel predicted genes, thus representing a resource for subsequent functional genomic analysis. We compare the European Drosophila Genome Project sequence with the corresponding part of the independently assembled and annotated Joint Sequence determined through "shotgun" sequencing. Discounting differences in the distribution of known transposable elements between the strains sequenced in the two projects, we detected three major sequence differences, two of which are probably explained by errors in assembly; the origin of the third major difference is unclear. In addition there are eight sequence gaps within the Joint Sequence. At least six of these eight gaps are likely to be sites of transposable elements; the other two are complex. Of the 275 genes in common to both projects, 60% are identical within 1% of their predicted amino-acid sequence and 31% show minor differences such as in choice of translation initiation or termination codons; the remaining 9% show major differences in interpretation.
- Published
- 2001
- Full Text
- View/download PDF
16. Review of the quarter's economic trends [February 1982]
- Author
-
Fraser, N., Bell, D., Hamilton, D., Jowett, A., McGilvray, J., McNicoll, I., Moar, L., O'Donnell, N., Simpson, D., Tait, E., Walker, J., Wingfield, A., and Fraser, N.
- Subjects
HB - Abstract
With unemployment having now passed the critical 3 million level there is intense pressure on the Chancellor to adopt a more reflationary stance in the coming Budget. Even within the confines of the present strategy there appears to be some scope for a limited expansion. This review of UK and world economic data will appraise recent economic performance and make predictions about future economic prospects.
- Published
- 1982
17. The Scottish economy [August 1982]
- Author
-
Fraser, N, Bell, D, Jowett, A, McGilvray, J, Moar, L, O'Donnell, N, Simpson, D, Tait, E, Walker, J, Wingfield, A, and Fraser, N
- Subjects
HD ,HB ,HJ - Abstract
The outlook for the Scottish, and indeed British, economy is not encouraging. The figures of industrial output for June record a fall of 1.5%, suggesting that the nascent recovery in output experienced earlier this year is in need of intense incubation. Both domestically and internationally there appears to be little sign of policies designed to assist any such incubation.
- Published
- 1982
18. The Scottish economy [October 1981]
- Author
-
Fraser, N., Bell, D., Hamilton, D., Harrigan, F., Jowett, A., McGilvray, J., McNicoll, I., Moar, L., O'Donnell, N., Simpson, D., Tait, E., Walker, J., Wingfield, A., and Fraser, N.
- Subjects
HD ,HF ,HB ,HJ - Abstract
Throughout this year economists, industrialists and politicians have been analysing and discussing the economy and making countervailing claims as to whether or not the recession is over. While many industrialists are clearly aware of the factors influencing their own business they are uncertain of the economy wide prospects. Meanwhile politicians couch their economic analysis in language which maximises their own political objectives. Similarly many economists attempt to defend the schools of thought upon which their reputations are staked. The conflicting viewpoints expressed have resulted in widespread confusion about the future prospects of both the Scottish and British economies. However, much of this confusion arises out of a failure to differentiate between the effect the current recession has had on the level of output and on the level of unemployment. It is widely recognised that a strong relationship exists between these variables and that changes in the level of unemployment lag behind changes in the level of output. It is worthwhile examining each of these factors and assessing their likely future movements.
- Published
- 1981
19. Review of the quarter's economic trends [August 1982]
- Author
-
Fraser, N, Bell, D, Jowett, A, McGilvray, J, Moar, L, O'Donnell, N, Simpson, D, Tait, E, Walker, J, Wingfield, A, and Fraser, N
- Subjects
HD ,HB ,HJ - Abstract
While the world economy has slowed down dramatically, the UK economy seems becalmed. Although industrial production fell in July at least GDP is not declining as it did during 1980 and 1981. However as yet there are no strong indications of a revival in economic activity.
- Published
- 1982
20. The Scottish economy [April 1981]
- Author
-
Bell, D.N.F., Fraser, N., Hamilton, D., Harrigan, F., Jowett, A., Kirwan, F., McGilvray, J., O'Donnell, N., Orton, I., Simpson, D., Tait, E., Walker, J., Wingfield, A., Bell, D.N.F., and Fraser, N.
- Subjects
HD ,HF ,HB - Abstract
The data analysed in this paper will show that whilst the end of the recession may be approaching, there is no strong evidence of any sustained or substantial recovery. Indeed, as highlighted in the UK section, there is no clear evidence that the mechanisms upon which the government are relying will generate a significant upturn. The UK economy is notoriously unresponsive to price signals, and while one should support governments efforts to increase this sensitivity, historical evidence is at best equivocal on the efficacy of this approach. For example, while the response of manufacturing investment to changes in output is unambiguously positive, the response to changes in the cost of capital is unclear. Indeed the Treasury have been unable to establish a significant relationship between manufacturing investment and capital cost and, in consequence, base their forecasts on the assumption that such a link exists. Further, any positive effects which might stem from a fall in interest rates will be dampened by the considerable spare capacity in the manufacturing sector brought about by the depth of the current recession.
- Published
- 1981
21. The textiles, leather, clothing and footwear sector in Scotland
- Author
-
Jowett, A., O'Donnell, N., and Tait, E.
- Subjects
HF ,HB - Abstract
The textiles, leather, clothing and footwear sector (TLCF) encompasses a wide variety of industries producing a heterogeneous collection of products. It is not within the scope of this brief to analyse in detail such a complex mix of industries. Therefore the purpose of this brief is to describe the performance of the sector as a whole, within the context of the Scottish economy and to discuss the observed trends in the main economic variables outlined below. It should be noted that a study of the data available for the TLCF sector reveals numerous inconsistencies and deficiencies.
- Published
- 1981
22. Review of the quarter's economic trends [April 1981]
- Author
-
Bell, D.N.F., Fraser, N., Hamilton, D., Harrigan, F., Jowett, A., Kirwan, F., McGilvray, J., O'Donnell, N., Orton, I., Simpson, D., Tait, E., Walker, J., Wingfield, A., Bell, D.N.F., and Fraser, N.
- Subjects
HB - Abstract
Present policies seem highly unlikely to return the UK economy to even the dismal growth path of the sixties and early seventies. This conclusion, unwelcome though it is, is made even more so by two additional factors. The first is the government's refusal to call their chosen strategy into question even in the face of an ever deepening recession and of a sustained logical onslaught on its theoretical underpinnings. The second is the absence of a coherent alternative strategy which carries the prospect of anything more than short-term amelioration of present problems. Further analysis of current UK economic conditions is provided, as too is an analysis of the world's economic performance.
- Published
- 1981
23. The Scottish economy [July 1981]
- Author
-
Fraser, N., Hamilton, D., Harrigan, F., Jowett, A., McNicoll, I., Moar, L., O'Donnell, N., Orton, I., Simpson, D., Tait, E., Walker, J., and Fraser, N.
- Subjects
HB - Abstract
The current economic situation is extremely depressed and recent events suggest that, without significant increases in economic activity, the political and social fabric of this country may be several strained. However, as argued in the UK section, the prospects for recovery are bleak and reliance on a purely financial strategy to restore growth is in itself inadequate. The source of real economic growth lies in the ability of labour, capital and enterprise to come together in a manner conducive to increased productivity over time. It is therefore worthwhile examining these factors of production to determine the effect of current policies upon them.
- Published
- 1981
24. Review of the quarter's economic trends [October 1981]
- Author
-
Fraser, N., Bell, D., Hamilton, D., Harrigan, F., Jowett, A., McGilvray, J., McNicoll, I., Moar, L., O'Donnell, N., Simpson, D., Tait, E., Walker, J., Wingfield, A., and Fraser, N.
- Subjects
HF ,HB ,HJ - Abstract
In the second quarter of 1981 the index of industrial production for the United Kingdom was 8% below its level for the corresponding period in 1980. This notwithstanding, there do appear to be signs that the bottom of the output trough may now have been reached. This brief section will seek to understand the latest UK and world economic data to determine current economic conditions and forecasts future trends.
- Published
- 1981
25. The Scottish economy [May 1982]
- Author
-
Fraser, N., Bell, D., Hamilton, D., Harrigan, F., Jowett, A., McGilvray, J., McNicoll, I., Moar, L., O'Donnell, N., Simpson, D., Tait, E., Wingfield, A., and Fraser, N.
- Subjects
HD ,HF ,HB - Abstract
The Scottish economy is taking the first tentative steps towards a recovery in industrial output. Indices of production have slowly started to edge upwards and the results of the April 1982 CBI Industrial Trends Survey show a growth in business confidence. While unemployment will continue to rise, those in work will be faced with less short-time working and increased opportunities for overtime. The prospects for significant long-term growth with a concomitant reduction in unemployment is, however, dependent on a number of factors both domestic and international.
- Published
- 1982
26. The Scottish economy [February 1982]
- Author
-
Fraser, N., Bell, D., Hamilton, D., Jowett, A., McGilvray, J., McNicoll, I., Moar, L., O'Donnell, N., Simpson, D., Tait, E., Walker, J., Wingfield, A., and Fraser, N.
- Subjects
HD ,HF ,HB - Abstract
The immediate economic prospects remain unfavourable particularly with regard to the level of unemployment. In the UK the number unemployed in January 1982 stands at a record 3,071,000. While the Scottish figure does not yet equal the figure of 407,000 recorded in January 1933, the present total of 346,547 represents a post-war high. Coupled with these figures is the rapid growth in the long-term unemployed ie those unemployed for more than a year. An examination of recent statistics from the Department of Employment shows that in the United Kingdom between October 1980 and October 1981, this category increased in number from 401 thousand to 785 thousand, an increase of nearly 961. In addition the Manpower Services Commission has recently lent its weight to the view that the true level of unemployment is around four million. As data show, even on very optimistic assumptions about the nature of unemployment and prospects for the labour market (see Employment and Unemployment Section), it is unlikely that unemployment will fall to historically acceptable levels.
- Published
- 1982
27. The Scottish economy [January 1981]
- Author
-
Bell, D.N.F., Hamilton, D., Harrigan, F., Jowett, A., Kirwan, F., McGilvray, J., O'Donnell, N., Orton, I., Simpson, D., Tait, E., Walker, J., and Wingfield, A.
- Subjects
HD ,HF ,HB - Abstract
The causes of the present recession are generally misunderstood. While it is undoubtedly the case that the growth of the world economy has been reduced, this has, as yet, had little effect on the UK. Exports have been surprisingly buoyant, benefiting perhaps from orders obtained when the pound was at a much lower level. Detailed forecasts, as well as additional analyses of the latest Scottish economic data, is provided to better understand Scotland's current economic predicament.
- Published
- 1981
28. Housing in Scotland
- Author
-
Bell, D.N.F., Fraser, N., Hamilton, D., Harrigan, F., Jowett, A., Kirwan, F., McGilvray, J., O'Donnell, N., Orton, I., Simpson, D., Tait, E., Walker, J., Wingfield, A., Bell, D.N.F., and Fraser, N.
- Subjects
HB - Abstract
The purpose of this Brief is to describe some of the main features of housing in Scotland as well as the implementation of housing policies. This is important as the state of housing in Scotland has long been recognised as a major determinant of the high levels of net migration, poor job mobility and of urban blight. After describing the Scottish housing stock, the final sections discuss trends in government expenditure, changes in house prices and the current debate over the sale of public authority housing.
- Published
- 1981
29. Review of the quarter's economic trends [May 1982]
- Author
-
Fraser, N., Bell, D., Hamilton, D., Harrigan, F., Jowett, A., McGilvray, J., McNicoll, I., Moar, L., O'Donnell, N., Simpson, D., Tait, E., Wingfield, A., and Fraser, N.
- Subjects
HB - Abstract
This section of the Commentary provides an overview of the latest world and UK economic data. Clearly, the foundation for recovery in 1982 is a fragile one, for the prospects for the main expenditure aggregates are not promising: world trade is not expected to grow significantly and could even decline if the pressures for protectionism (arising mainly from high domestic unemployment) are translated into action. Real consumer expenditure is likely to remain relatively static since the growth rate of nominal disposable income is moving towards that of price inflation in most industrialised countries, and is even falling behind in some. High interest rates and company balance sheets still reeling from the effects of recession continue to depress investment prospects, and the continuing concern of governments with the size of public sector deficits makes any significant increase in autonomous (as opposed to 'automatic' counter-cyclical) public expenditure improbable. These factors, coupled with their generally consistently over-optimistic forecasts for 1982 made a year ago, have made most forecasters much more cautious in predicting the extent of recovery later in 1982, and some are even suggesting that this recovery may not be sustained far into 1983. 1
- Published
- 1982
30. Projections of the Scottish economy to 1984
- Author
-
Fraser, N., Bell, D., Hamilton, D., Jowett, A., McGilvray, J., McNicoll, I., Moar, L., O'Donnell, N., Simpson, D., Tait, E., Walker, J., Wingfield, A., and Fraser, N.
- Subjects
HB - Abstract
The October 1979 issue of this Commentary (Volume 5 No 2) included an article which described the outline structure of a Medium Term Model of Scotland, designed to be used for forecasts or projections of the economy for periods beyond the established 6-12 months of the Institute's short-term forecasting model. Since late 1979, work has concentrated on the precise formulation of the model, data collection, the estimation of the parameters of the model, and tests of its accuracy. In the latter part of 1981, the model was used to generate projections (or conditional forecasts) of the Scottish economy in 1984. Details of the construction and testing of the model, and of the 1984 projections are to be published shortly. This article contains a synopsis of that report, emphasising in particular the results of the 1984 projections. For reasons of length, and of the orientation of this Commentary towards empirical and policy issues, description and evaluation of the estimation and testing of the model is limited; attention is concentrated on the results of the projections. Readers interested in the structure and estimation of the model are referred to the forthcoming report.
- Published
- 1982
31. The Scottish fishing industry : a survey of the catching sector
- Author
-
Bell, D.N.F., Hamilton, D., Harrigan, F., Jowett, A., Kirwan, F., McGilvray, J., O'Donnell, N., Orton, I., Simpson, D., Tait, E., Walker, J., and Wingfield, A.
- Subjects
HF ,HB - Abstract
The Scottish fishing industry is divided into two main sectors: catching and processing. The brief explores the latest economic data of this important industrial sector and provides an analysis of the influence of fishery policy on economic growth.
- Published
- 1981
32. On the merits and pitfalls of introducing a digital platform to aid conservation management: Volunteer data submission and the mediating role of volunteer coordinators.
- Author
-
Arts K, Melero Y, Webster G, Sharma N, Tintarev N, Tait E, Mellish C, Sripada S, MacMaster AM, Sutherland H, Horrill C, Lambin X, and van der Wal R
- Subjects
- Humans, Scotland, Conservation of Natural Resources, Volunteers
- Abstract
Against a backdrop of accelerating digital innovation in nature conservation and environmental management, a real-world experiment was conducted with the research aims of assessing: 1) the effects of introducing a digital data-entry platform on volunteer data submission; and 2) the extent to which coordinators influence digital platform use by their volunteers. We focussed on a large-scale volunteer-based initiative aimed at eradicating the non-native American mink (Neovison vison) from northern Scotland. This geographically dispersed conservation initiative adopted a digital platform that allowed volunteers to submit records to a central database. We found that the platform had a direct and positive effect on volunteer data submission behaviour, increasing both the number and frequency of submissions. However, our analysis revealed striking differences in coordinator engagement with the platform, which in turn influenced the engagement of volunteers with this centrally introduced digital innovation. As a consequence, the intended organisation-wide rolling out of a digital platform translated into a diversely-implemented innovation, limiting the efficacy of the tool and revealing key challenges for digital innovation in geographically-dispersed conservation initiatives., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
33. Successful recruitment to trials: findings from the SCIMITAR+ Trial.
- Author
-
Peckham E, Arundel C, Bailey D, Callen T, Cusack C, Crosland S, Foster P, Herlihy H, Hope J, Ker S, McCloud T, Romain-Hooper CB, Stribling A, Phiri P, Tait E, and Gilbody S
- Subjects
- Attitude of Health Personnel, Cooperative Behavior, England, Health Knowledge, Attitudes, Practice, Humans, Interdisciplinary Communication, Mental Disorders diagnosis, Physicians psychology, Research Personnel psychology, Sample Size, Smoking adverse effects, Time Factors, Mental Disorders psychology, Mental Health, Patient Selection, Smokers psychology, Smoking psychology, Smoking Cessation psychology
- Abstract
Background: Randomised controlled trials (RCT) can struggle to recruit to target on time. This is especially the case with hard to reach populations such as those with severe mental ill health. The SCIMITAR+ trial, a trial of a bespoke smoking cessation intervention for people with severe mental ill health achieved their recruitment ahead of time and target. This article reports strategies that helped us to achieve this with the aim of aiding others recruiting from similar populations., Methods: SCIMITAR+ is a multi-centre pragmatic two-arm parallel-group RCT, which aimed to recruit 400 participants with severe mental ill health who smoke and would like to cut down or quit. The study recruited primarily in secondary care through community mental health teams and psychiatrists with a smaller number of participants recruited through primary care. Recruitment opened in October 2015 and closed in December 2016, by which point 526 participants had been recruited. We gathered information from recruiting sites on strategies which led to the successful recruitment in SCIMITAR+ and in this article present our approach to trial management along with the strategies employed by the recruiting sites., Results: Alongside having a dedicated trial manager and trial management team, we identified three main themes that led to successful recruitment. These were: clinicians with a positive attitude to research; researchers and clinicians working together; and the use of NHS targets. The overriding theme was the importance of relationships between both the researchers and the recruiting clinicians and the recruiting clinicians and the participants., Conclusions: This study makes a significant contribution to the limited evidence base of real-world cases of successful recruitment to RCTs and offers practical guidance to those planning and conducting trials. Building positive relationships between clinicians, researchers and participants is crucial to successful recruitment.
- Published
- 2018
- Full Text
- View/download PDF
34. Subcellular antigen location influences T-cell activation during acute infection with Toxoplasma gondii.
- Author
-
Gregg B, Dzierszinski F, Tait E, Jordan KA, Hunter CA, and Roos DS
- Subjects
- Adoptive Transfer, Animals, Antigen-Presenting Cells immunology, Blotting, Western, Cells, Cultured, Female, Fluorescent Antibody Technique, Humans, Major Histocompatibility Complex immunology, Mice, Mice, Inbred C57BL, Ovalbumin physiology, Subcellular Fractions, Toxoplasma genetics, Toxoplasma immunology, Toxoplasmosis metabolism, Vacuoles parasitology, Antigens, Protozoan immunology, CD8-Positive T-Lymphocytes immunology, Lymphocyte Activation immunology, Toxoplasmosis immunology, Toxoplasmosis parasitology, Vacuoles immunology
- Abstract
Effective control of the intracellular protozoan parasite Toxoplasma gondii depends on the activation of antigen-specific CD8(+) T-cells that manage acute disease and prevent recrudescence during chronic infection. T-cell activation in turn, requires presentation of parasite antigens by MHC-I molecules on the surface of antigen presenting cells. CD8(+) T-cell epitopes have been defined for several T. gondii proteins, but it is unclear how these antigens enter into the presentation pathway. We have exploited the well-characterized model antigen ovalbumin (OVA) to investigate the ability of parasite proteins to enter the MHC-I presentation pathway, by engineering recombinant expression in various organelles. CD8(+) T-cell activation was assayed using 'B3Z' reporter cells in vitro, or adoptively-transferred OVA-specific 'OT-I' CD8(+) T-cells in vivo. As expected, OVA secreted into the parasitophorous vacuole strongly stimulated antigen-presenting cells. Lower levels of activation were observed using glycophosphatidyl inositol (GPI) anchored OVA associated with (or shed from) the parasite surface. Little CD8(+) T-cell activation was detected using parasites expressing intracellular OVA in the cytosol, mitochondrion, or inner membrane complex (IMC). These results indicate that effective presentation of parasite proteins to CD8(+) T-cells is a consequence of active protein secretion by T. gondii and escape from the parasitophorous vacuole, rather than degradation of phagocytosed parasites or parasite products.
- Published
- 2011
- Full Text
- View/download PDF
35. Mapping and identification of essential gene functions on the X chromosome of Drosophila.
- Author
-
Peter A, Schöttler P, Werner M, Beinert N, Dowe G, Burkert P, Mourkioti F, Dentzer L, He Y, Deak P, Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Klapper R, Janning W, Glover DM, Ashburner M, Bellen HJ, Jäckle H, and Schäfer U
- Subjects
- Animals, Chromosomes, Artificial, Bacterial, Contig Mapping, DNA Probes, DNA Transposable Elements, Female, Genes, Essential, Genes, Insect, Male, Mutagenesis, Chromosome Mapping, Drosophila melanogaster genetics, X Chromosome
- Abstract
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics Systems, have sequenced the genome, complementing the previously established physical and genetic maps. In addition, the Berkeley Drosophila Genome Project has undertaken large-scale functional analysis based on mutagenesis by transposable P element insertions into autosomes. Here, we present a large-scale P element insertion screen for vital gene functions and a BAC tiling map for the X chromosome. A collection of 501 X-chromosomal P element insertion lines was used to map essential genes cytogenetically and to establish short sequence tags (STSs) linking the insertion sites to the genome. The distribution of the P element integration sites, the identified genes and transcription units as well as the expression patterns of the P-element-tagged enhancers is described and discussed.
- Published
- 2002
- Full Text
- View/download PDF
36. Prevalence of small inversions in yeast gene order evolution.
- Author
-
Seoighe C, Federspiel N, Jones T, Hansen N, Bivolarovic V, Surzycki R, Tamse R, Komp C, Huizar L, Davis RW, Scherer S, Tait E, Shaw DJ, Harris D, Murphy L, Oliver K, Taylor K, Rajandream MA, Barrell BG, and Wolfe KH
- Subjects
- Chromosomes, Fungal, Gene Rearrangement, Genome, Fungal, Candida albicans genetics, Chromosome Inversion, Evolution, Molecular, Genes, Fungal, Saccharomyces cerevisiae genetics
- Abstract
Gene order evolution in two eukaryotes was studied by comparing the Saccharomyces cerevisiae genome sequence to extensive new data from whole-genome shotgun and cosmid sequencing of Candida albicans. Gene order is substantially different between these two yeasts, with only 9% of gene pairs that are adjacent in one species being conserved as adjacent in the other. Inversion of small segments of DNA, less than 10 genes long, has been a major cause of rearrangement, which means that even where a pair of genes has been conserved as adjacent, the transcriptional orientations of the two genes relative to one another are often different. We estimate that about 1,100 single-gene inversions have occurred since the divergence between these species. Other genes that are adjacent in one species are in the same neighborhood in the other, but their precise arrangement has been disrupted, probably by multiple successive multigene inversions. We estimate that gene adjacencies have been broken as frequently by local rearrangements as by chromosomal translocations or long-distance transpositions. A bias toward small inversions has been suggested by other studies on animals and plants and may be general among eukaryotes.
- Published
- 2000
- Full Text
- View/download PDF
37. From sequence to chromosome: the tip of the X chromosome of D. melanogaster.
- Author
-
Benos PV, Gatt MK, Ashburner M, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demailles J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Minana B, Kafatos FC, Louis C, Sidén-Kiamos I, Bolshakov S, Papagiannakis G, Spanos L, Cox S, Madueño E, de Pablos B, Modolell J, Peter A, Schöttler P, Werner M, Mourkioti F, Beinert N, Dowe G, Schäfer U, Jäckle H, Bucheton A, Callister DM, Campbell LA, Darlamitsou A, Henderson NS, McMillan PJ, Salles C, Tait EA, Valenti P, Saunder RD, and Glover DM
- Subjects
- Animals, Chromosome Banding, Computational Biology, Cosmids, DNA Transposable Elements, DNA, Satellite, Genes, Insect, In Situ Hybridization, Repetitive Sequences, Nucleic Acid, Sequence Analysis, DNA, X Chromosome ultrastructure, Drosophila melanogaster genetics, X Chromosome genetics
- Abstract
One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.
- Published
- 2000
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.