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1. A MOBILE MULTI-SENSOR PLATFORM FOR BUILDING RECONSTRUCTION INTEGRATING TERRESTRIAL AND AUTONOMOUS UAV-BASED CLOSE RANGE DATA ACQUISITION

Author

A. Cefalu, N. Haala, S. Schmohl, I. Neumann, and T. Genz

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Photogrammetric data capture of complex 3D objects using UAV imagery has become commonplace. Software tools based on algorithms like Structure-from-Motion and multi-view stereo image matching enable the fully automatic generation of densely meshed 3D point clouds. In contrast, the planning of a suitable image network usually requires considerable effort of a human expert, since this step directly influences the precision and completeness of the resulting point cloud. Planning of suitable camera stations can be rather complex, in particular for objects like buildings, bridges and monuments, which frequently feature strong depth variations to be acquired by high resolution images at a short distance. Within the paper, we present an automatic flight mission planning tool, which generates flight lines while aiming at camera configurations, which maintain a roughly constant object distance, provide sufficient image overlap and avoid unnecessary stations. Planning is based on a coarse Digital Surface Model and an approximate building outline. As a proof of concept, we use the tool within our research project MoVEQuaD, which aims at the reconstruction of building geometry at sub-centimetre accuracy.

Published
2017
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2. Isovolämische Hämodilution (IHD) zur Einsparung von Fremdblut-transfusionen: Effektivität bei großen gynäkologischen Eingriffen

Author

U. Kreimeier, H. Bernasconi, T. Genz, M. Oberhauser, and H.J. Bardenheuer

Subjects
Immunology and Allergy, Hematology
Abstract

Ziel: Die Praktikabilität und Effektivität einer standardisierten, unmittelbar präoperativ durchgeführten isovolämischen Hämodilution wurde bei großen gynäkologischen Eingriffen (Wertheim-Operation u. a.) untersucht. Design: Prospektive klinische Studie mit historischer Vergleichsgruppe. Rahmen: Operations-saal einer gynäkologischen Universitätsklinik. Patienten und In-terventionen: Bei 48 Patientinnen (mittleres Alter: 53 Jahre) wurde in Allgemeinanästhesie eine Hämodilution auf eine H-ämoglobinkonzentration von 9 g/dl durchgeführt (Abnahmemen-ge 900 ± 210 ml). Intraoperativ wurde bei Unterschreiten eines Hb-Wertes von 7 g/dl Eigenblut bzw. Fremdblut transfundiert. Ergebnisse: Gegenüber dem Vergleichskollektiv von 57 Patientinnen ohne Hämodilution wurde die Gesamtzahl an Fremdbluttransfusionen signifikant reduziert. Perioperativ konnte bei 65% aller Patientinnen jegliche Fremdblutübertragung vermie-den werden (Kontrollgruppe: 21%). Unerwünschte Nebenwir-kungen traten nicht auf. Schlußfolgerungen: Die Untersuchung zeigt, daß die akute isovolämische Hämodilution bei großen gynäkologischen Eingriffen ein sicheres, leicht zu handhaben-des und effektives Verfahren ist, das erlaubt, bis zu einem Ge-samtblutverlust von 1300 bis 1400 ml – in Einzelfällen auch dar-über – gänzlich auf eine Fremdbluttransfusion zu verzichten.

Published
1996
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4. Contents, Vol. 33, Supplement 1, 1993

Author

A. Reinthaller, O. Wilhelm, D. Kölle, A. Staudach, R. Schröck, J.W. Hosmann, F. Wierrani, Gundula Klocke, M. Zajc, T. Genz, M. Wimbauer, L.C. Fuith, M. Stöhrer, E. Hanzal, A. Adler, P. Speiser, Ursula Loidl, T. Schramm, C. Ruppert, K. Philipp, D. Weiss, E. Kind, E. Wierrani, P. Kracher, F. Friedrich, St. Flachowsky, H. Auner, J. Gnirs, P. Riss, M. Schwiersch, H. Kölbl, R. Sauer, B. Bakker, W. Schöll, V. Möbus, P. Dörffler, U. Denison, M. Auer-Grumbach, M. van Trotsenburg, M. Korell, C. Marth, Ch. Kainz, C. Hellmich, K.-H. Wulf, K. Tamussino, Ch. Breuel, E. Neu, R. Kreienberg, J.C. Huber, H.G. Sainz, H.K. Selbmann, R. Voigt, G. Konecny, S. Wilhelm, K.-P Gloning, G. Quittan, N. Lang, Anita Prechtl, A. Schumitz, M. Löw, J. Thurner, A. Hofstetter, M. Huber, Ch. Dittrich, R. Wiborny, B. Haffner, S. Molnar, M. Kolben, W. Seidenbusch, Ch. Vutuc, Schadia Jinniate, Johannes Kunz, M. Schmitt, M. Zorzi, B. Lampe, H. Kiss, H. Salzer, K. Baumgarten, P. Sevelda, P. Lang, L. Pache, Kinga Chalubinski, M. Ulm, F. Heuss, H. Karras, D. Berg, Dorrit Weiss, R. Schulz-Wendtland, M. Putz, H. Pickel, Liane Kunert, G. Schied, W. Matal, Ulrike Heil, G. Pinzger, S. Todorow, H.G. Bender, Ch. Dadak, G. Schönauer, J. Stepien, M. Heydarfadai, S. Müller-Reiter, P. Baumgartner, St. Schulz, M. Manavi, A. Zuckermann, Inge Schreiner-Frech, E. Brusis, H. Gründling, K. Swoboda, Burgi Kaltenegger, N. Harbeck, Elisabeth Küffer, K. Eibner, E. Küffer, N. Adelwöhrer, R. Zeillinger, A. Schröck, P. Dettmar, G.J. Gerstner, C. Klinger, R. Höpfl, S. Reindke, W. Grünberger, A. Schönwälder, W. Schramm, F. Gill, I. Müller-Hartburg, E. Wolner, T. Wagner, T. Steck, P. Husslein, M. Widschwendtner, W. Schneider, M. Lahousen, Eva A. Dumler, W. Schweiger, H. Prömer, E. Petru, M. Batka, H. Enzelsberger, K. Reisenberger, A. Feiks, G. Windbichler, H.A. Tulusan, Y. Lu, A. Martan, G. Krüsmann, V. Strnad, E. Siebzehnrübl, A. Waitz-Penz, M.Di. Paolo, W. Walcher, M. Seifert, E. Hafner, G. Bernaschek, A. Zeimet, H. Haberfellner, I. Wilke, H.-J. Semmelrock, M. Steidl, S. King, H. Grebmeier, T.W.A. Huisman, Nadia Harbeck, D. Fuchs, M. Czarnecki, K. Fiedler, S. Leodolter, H. Wachter, H. Maurer, E. Kubista, B. Fazeny, A. Lohninger, Kristina Schanzer, M. Lange, Marianne Springer-Kremser, G. Häusler, M. Dorfer, K. Rotte, M. Untch, E. Abfalter, M. Bühner, H. Caffier, A.H. Tulusan, H. Janisch, J.W. Wladimiroff, V. Cavusoglou, R. Obwegeser, L. Prayer, W. Jaud, W. Michels, J. Scholler, W. Gruber, D. Kranzfelder, M. Neumann, F. Nagele, R.v. Hugo, Eva Joura, D. Spitzer, H. Schaffer, G. Lorenz-Eberhardt, D. Egner, R. Kimmig, M. Dostert, G. Breitenecker, S. Tatschl, A.-H. Graf, I. Stümpflen, H. Kaesemann, A. Bergant, M. Rehn, M. Kafta, N Yamamoto, P. Pürstner, W. Schemper, G. Gitsch, H. Helmer, P. Kastner, F. Jänicke, A. Tulusan, M. Novak, J. Deutinger, P.A.M. Weiss, I. Funke, Beate Riedl, L. Wildt, L. Müller, K. Gruböck, G. Meyberg, F. Zivkovic, W. Jäger, W. Grin, A. Schauer, J. Wisser, T. Strowitzki, D. Möhrling, R. Kupietz, Ch. Bali, A.M. Koch, R. Knitza, R. Lassmann, Andrea Fink, B. Seelbach-Göbel, M. Schoderbeck, Regine Ahner, P.J. Albert, K.-Ph. Gloning, H. Kraxner, K.J. Neiss, H. Weidinger, J. Burkl, E. Schüren, W. Hönigl, J. Rehbock, H. Hepp, K.T.M. Schneider, W. Loos, E. Müller-Holzner, O. Heiss, K.F. Czerwenka, E. Sölder, H. Rauschecker, K. Heim, M. Stumpfe, E. Husslein, S. Krämer, M. Bauer, H.-M. Böhm, J. Endl, H. Höfler, M.Ch. Michailov, C. Anthuber, U. Bogner, A.G. Zeimet, F. Ebner, P. Weiss, Ch. Schmid, M. Schumacher, K. Irsigler, M. Langer, K. Tempel, M. Halaska, K. Schuchter, W. Zeilmann, J. Wortmann, N. Vavra, J. Haas, N. Atanasov, A. Obermair, A. Bittl, P. Voigt, J. Schmidt, Ch. Sohn, U. Welscher, B. Wartusch, M. Ringler, A. Rempen, C. Ploner-Strobl, A. Büttner, Christine Kurz, Ch. Brezinka, M. Böhm, H. Graeff, K. Klingenbeck, W. Schroder, W. Freidl, T. Dimpfl, A. Gedik, A. Gold, G. Kindermann, C. Fidi, D. Pfeiffer, R. Winter, W. Würfel, Ch. Bieglmayer, S. Anthuber, J. Egger, E. Müllner-Holzner, G. Daxenbichler, H. Heidegger, N.E. Adelwöhrer, D. Löchner-Ernst, P. Brandner, T. Puchner, M. Saks, O. Dapunt, K. Baier, D. Jelincic, E. Greimel, O. Heiß, S. Jinniate, F. Gücer, A. Riesselmann, C. Nestle-Krämling, E. Golob, B. Nakhla, G. Debus-Thiede, Edith Rammer, N. Willich, G. Wolf, A. Untch, Ralph George, R. Altrichter, Ch. Kurz, Christine Sam, W. Lechner, B.U. Sevin, R. Mai, R. Deckardt, Eva Ostermayer, Z. Maly, Ch. Egarter, R. Wisleitner, H. Steiner, P. Kristen, and K. Bihler

Subjects
Obstetrics and Gynecology, General Medicine
Published
1993
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5. Contents, Vol. 31, Supplement 2, 1991

Author

R. Schröck, M. Menton, G. Freude, K. Czerwenka, E. Holm, J. Hermann, G. Mitterschiffthaler, W.D. Skodler, C. Marth, B. Schießl, J. Spona, R. Faber, K. Kupf, Kerstin Hiller, Elisabeth Vytiska-Binstorfer, G. Gmoser, A. Beck, A. Rosen, J. Lahodny, Eva Ostermayer, B. Wartusch, M. Stumpfe, G. Luschin-Ebengreuth, P. Wieacker, E. Kuβ, D. Lampe, Cornelia Schweighart, G. Tulzer, R. Steldinger, R. Voigt, W. Schnedl, B. Sitte, E. Doringer, W. Walcher, J.C. Huber, E. Greimel, U. Ruppitsch, E. Stumberger, U. Steinhart, W. Rosenkranz, P.H. Wünsch, H. Kölbl, R. Zeillinger, P. Fritsch, W. Kozak, D. Szendzielorz, R. Krepler, U. Fürstenau, H. Steiner, C. Thomssen, G. Debus-Thiede, T. Strowitzki, P. Kentner, H. Hofbauer, A. Riehn, R.v. Hugo, H. Salzer, M.S. Zach, B. Hofwarter, S. Schramm, R. Winter, H.O. Mayer, J. Baltzer, Lieselotte Winkler, H. Janisch, W. Oettle, D. Kölle, K.T.M. Schneider, E. Arnold, F. Welponer, W. Schramm, C. Schatten, F. Wierrani, M. Schuster, E. Petru, B. Wang-Artner, Ch. Kainz, P. Eberl-Lehmann, H. Pickel, N. Lack, G. Tatra, L. Wildt, J. Jawny, D. Weiss, T. Schramm, G. Tews, M. Medl, P. Scheidel, B. Rudelstorfer, A. Reinthaller, V. Fabrizii, Beate Kästner, C. Lauritzen, Nadia Harbeck, F. Staufer, Ch. Thieme, B. Oberwaldner, M. Hölscher, E. Müller-Holzner, K.-E. Ruckhäberle, M. Wolters, K. Radivojevic, S. Leodolter, Barbel Justus, G. Hagen, J. Kurbacher, Maria Simml, K. Weghaupt, H. HÖfler, M. Eisenmenger, Ter Meulen, W.G. Rossmanith, M. Seifert, C. Baseler, I. Jochmus-Kudielka, H. Strampfer, M. Schwiersch, H. Schenk, R. Robel, B. Getz, H. Rollett, M. Heydarfadai, P. Kohlberger, E. Merkle, E. Holböck, J. Haas, J.W. Hosmann, R. Deckardt, H. Sommer, M. Barrada, J. Buschmann, H. Hepp, E. Müller-Tyl, J. Burkl, M. Woltsche, P. Schwegel, G. Berclaz, T. Steck, T. Wagner, R. Rudelstorfer, T. Gyr, N. Endler, N. Moniwa, T. Lang, H. Joos, H. Kucera, Ch. Nowotny, M. Korell, Christine Kurz, N. Pateisky, G. Quittan, Ute Herzog, V. Sasse, G. Schüle, D. Spitzer, L. Gissmann, G. Methfessel, P. Speiser, R. Kürzl, D. Amberg-Wendland, E. Brusis, F. Kury, K. Ketscher, W. Lechner, E.A. Dumler, M. Lahousen, P. Kristen, K. Fiedler, S. Gudmundsson, A. Pflaumer, W. Kuhn, N. Lang, J. Wisser, M. Schmitt, U. Finsterer, P. Hirsch, W. Hönigl, J. Egger, P. Balcke, F. Allerberger, Ch. Dadak, H. Enzelsberger, K. Derfler, Marina Marcovich, E.D. Mauch, H.U. Bratschi, A. Bergant, F. Fischl, F. Mittermayer, P. Sevelda, Ildiko Salanki, D. Täubert, E. Pastner, C. Breuel, R. Austin, W. Knogler, Anna Streitmatter, W. Jäger, E. Beinder, Ch. Kurz, Brigitte Pechter, B. Viehweg, K. Kosian, A. Obermair, M. Sandbichler, D. Markus, J. Schöffel, R. Wiborny, M. Neises, H.P. Dimai, U. Wirth, V. Maaβen, D.C. Wood, B. Schüβler, E. Reinold, Ivo Fischer, Birgit Seelbach-GÖbel, M.C.H. Häusler, M. Manavi, S. Krone, Ch. Vutuc, F. Fischbach, A. Delucca, A. Feiks, F. Friedrich, Edeltraud Kurt, B. Bartosch, H. Graeff, F. Seibert, Sabine Schweiberer, N. Sepp, H.D. Methfessel, R. von Hugo, G. Ralph, A. Waitz-Penz, M. Saks, A. Hümpfner, A. Schaller, Riehn F, H. Nöschel, Ch. Bieglmayer, A.C. Stuckert-Klein, N.E. Adelwöhrer, O. Dapunt, M. Schelling, E. Abfalter, K. Swoboda, M. Schemper, L. Michelitsch, E. Beck, F. Jänicke, J.C. Huhta, H. Kaesemann, K.-Ph. Gloning, B. Meier, K. Riedel, R. Fitz, G. Krüsmann, E. Sölder, C.M. Kurbacher, P. Brock, F. Girardi, J. Auner, A. Lörken, B. Schurz, H. Zech, N. Vavra, K. Höbarth, G. Pinzger, K. Brandt, P. Strigl, M. Breckwoldt, A.H. Tulusan, E. Paterok, W. Heis, A. Berg, K.F. Czerwenka, M. Batka, T. Genz, L. Pache, R. Klieber, H.J. Voigt, H. Caffier, G. Guggenbichler, G. Lorenz-Eberhardt, M. Peschke, G. Breitenecker, A. Adler, S. Petraki, A. Wischnik, H. Wernze, M. Glawischnig, W. Weise, K. Heim, U.V. Wisiak, M.W. Beckmann, R. Hegerfeld, K. Eglau, R. Senekowitsch, Maria Haidinger, J. Stepien, M. Meyer, H. Heidegger, R. Lassmann, E. Busch, H.-J. Beier, K. Spatzier, U. Hesse, K. Tamussino, P. DÖrffler, U. Denison, H. Schneider, R. Knitza, W. Kopp, R. Höpfl, A. Schlager, H. Kirchler, M. Klein, T. Sander, H.H. Pusch, A. Staudach, W. Freidl, E. Mauch, H. Schröcksnadel, D. Stech, A. Rempen, B. Hartmann, R. Benz, E. Wiest, W. Urdl, Katrin Schaudig, S. Schüßler, U. Artmeier, M. Häusler, C. Fellbaum, W. Grünberger, J. Keckstein, P.A.M. Weiβ, J. Forberg, T. Dimpfl, H.P. Friedl, H. Schaffer, M. Kolben, W. Würfel, Ulla Link, M. Halaška, Cornelia Schweighardt, A. Alge, H. Schünemann, P.J. Albert, Edith Rammer, E. Siebzehnrübl, G. Gitsch, G. Daxenbichler, G. Hofer, S. Renz, S. Todorow, and E. Kubista

Subjects
Obstetrics and Gynecology, General Medicine
Published
1991
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6. Matched pair analysis of survival after chest-wall recurrence compared to mammary recurrence: a long-term follow up

Author

Wolfgang Janni, T. Genz, T. Dimpfl, Naim Shabani, B. Lampe, U. Peschers, D. Rjosk, L. Starflinger, and F. Bergauer

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Multivariate analysis, Skin Neoplasms, Time Factors, medicine.medical_treatment, Matched-Pair Analysis, Breast Neoplasms, Metastasis, Breast cancer, Risk Factors, Internal medicine, medicine, Humans, Risk factor, Lymph node, Survival rate, Mastectomy, Proportional Hazards Models, Observer Variation, Univariate analysis, Analysis of Variance, business.industry, General Medicine, Middle Aged, medicine.disease, Prognosis, Survival Analysis, Surgery, medicine.anatomical_structure, Treatment Outcome, Lymphatic Metastasis, Female, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

Background: Local recurrence remains a major concern after primary treatment of breast cancer and has a major impact on subsequent survival. While most studies report a poorer survival rate in patients with a local recurrence after mastectomy than after breast conservation, it remains controversial whether different risk profiles at the time of primary diagnosis may account for this difference. Method: Matched pair analysis of 134 patients with newly diagnosed locoregional recurrence of breast cancer without evidence of systemic disease. Matching criteria included the primary surgical treatment, tumor size, nodal status, and age. The significance of various prognostic parameters at the time of primary diagnosis and at the time of recurrence were evaluated, by univariate and multivariate analyses, with respect to survival after recurrence. The median follow-up was 8.4 years. Results: Risk factors at the time of presentation, such as tumor size and lymph node status, were comparable between both groups. Local recurrence occurred on an average 9 months earlier in patients after mastectomy (P=0.08). Univariate analysis showed that lymph node status (P=0.0001) and disease-free interval from primary treatment to local recurrence (P=0.0002) were the most significant single prognostic factors for subsequent survival after local recurrence. The primary surgical treatment modality was shown to be of marginal statistical influence (only P=0.05). Conclusion: Local recurrence after mastectomy seems to be associated with worse survival than after breast-conserving therapy. Early onset of chest-wall recurrence, moreover, represents the highest independent risk for cancer-associated death.

Published
2001

7. Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells

Author

K, Pantel, G, Schlimok, D, Kutter, G, Schaller, T, Genz, B, Wiebecke, R, Backmann, I, Funke, and G, Riethmüller

Subjects
Colon, Histocompatibility Antigens Class I, Stomach, Down-Regulation, Humans, Breast Neoplasms, Adenocarcinoma, Neoplasm Metastasis
Abstract

An astoundingly high frequency of micrometastatic cells have been found in bone marrow aspirates of patients with colon carcinomas (G. Schlimok et al., J. Clin. Oncol., 8:831-837, 1990), although these tumors very rarely metastasize to the skeleton. This observation has raised questions about the malignant potential of such cells. In a first attempt to characterize this potential, we have assessed the expression of major histocompatibility complex (MHC) class I antigens on bone marrow micrometastases, inasmuch as down-regulation of these molecules is a potential mechanism to escape from MHC class I-restricted lysis by cytotoxic T-cells. The two groups of cancer patients compared were those with tumors known to rarely (stomach and colon cancer) or frequently (breast cancer) manifest skeleton metastases. Bone marrow aspirates taken from these patients were probed for individual disseminated tumor cells using the immunoalkaline phosphatase technique with monoclonal antibody CK2 to the epithelial differentiation antigen cytokeratin 18 (CK-18), as described previously (G. Schlimok et al., Proc. Natl. Acad. Sci. USA, 84:8672-8676, 1987). Specimens containing CK18-positive cells were colabeled with monoclonal antibody W6/32 directed to a framework (or nonpolymorphic) antigenic determinant of MHC class I heavy chains associated with beta 2-microglobulin. W6/32-positive CK-18-positive cells could be detected in 25 of 54 patients (46.3%) with significantly higher incidences in 26 breast cancer patients (61.9%) as compared to 28 patients with carcinomas of the stomach and colon (27.3 and 29.4%). Independent from the origin of the primary carcinoma, the incidence of W6/32-negative CK18-positive cells was positively correlated to both the differentiation grade of the primary tumor (P less than 0.05) and appeared to be linked to the occurrence of regional lymph node metastases (statistically not significant) determined by conventional histological examination. The present results demonstrate for the first time that down-regulation of MHC expression on individual micrometastatic cells correlates to the differential pattern of metastasis obtained by comparing breast and gastrointestinal carcinomas. This finding together with the suggestive link to clinical risk factors supports the significance of reduced MHC class I expression for the survival of residual metastatic cells which is a major determinant of prognosis for patients with solid tumors.

Published
1991

10. Jahrestagung der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe und der Bayerischen Gesellschaft für Geburtshilfe und Frauenheilkunde

Author

K.-H. Wulf, Ch. Breuel, Gundula Klocke, E. Neu, Ursula Loidl, A. Martan, G. Krüsmann, W. Grin, M. Kolben, W. Seidenbusch, G. Bernaschek, K. Eibner, E. Küffer, E. Wierrani, E. Siebzehnrübl, Kristina Schanzer, M. Steidl, Marianne Springer-Kremser, K. Rotte, T. Wagner, K. Gruböck, F. Zivkovic, R. Kupietz, M. Ringler, M. Schoderbeck, Regine Ahner, E. Petru, E. Husslein, U. Denison, Eva Ostermayer, M. Dorfer, M. Kafta, P. Pürstner, K. Philipp, T.W.A. Huisman, G. Pinzger, R. Obwegeser, L. Prayer, W. Michels, J. Scholler, Ch. Brezinka, M. Böhm, H. Graeff, P. Riss, J. Thurner, M. Huber, J. Wisser, Z. Maly, Burgi Kaltenegger, Ch. Egarter, R. Wisleitner, S. Tatschl, A. Tulusan, M. Schwiersch, G. Schied, D. Pfeiffer, E. Müllner-Holzner, J. Deutinger, W. Schöll, R.v. Hugo, H. Kölbl, R. Sauer, M.Ch. Michailov, K. Tamussino, H. Steiner, H.A. Tulusan, Ch. Sohn, M. Novak, G. Daxenbichler, T. Schramm, C. Ruppert, Eva A. Dumler, D. Spitzer, H. Schaffer, C. Anthuber, W. Jäger, G. Lorenz-Eberhardt, M. Heydarfadai, W. Schweiger, P. Kristen, K. Baumgarten, U. Bogner, P. Kracher, B. Haffner, E. Sölder, F. Friedrich, M. van Trotsenburg, R. Voigt, H. Enzelsberger, K. Reisenberger, B. Fazeny, R. Lassmann, R. Schröck, O. Dapunt, T. Steck, A.M. Koch, P. Sevelda, P. Lang, Inge Schreiner-Frech, Ch. Kainz, J.W. Wladimiroff, V. Cavusoglou, P. Husslein, Edith Rammer, K. Tempel, J.W. Hosmann, O. Heiß, B. Lampe, A. Waitz-Penz, W. Walcher, A. Schauer, F. Nagele, J.C. Huber, M. Stumpfe, A. Schröck, G. Gitsch, A.G. Zeimet, S. Krämer, F. Wierrani, M. Seifert, M. Bauer, N. Willich, M. Widschwendtner, A. Bergant, M. Rehn, A. Zeimet, A. Obermair, H. Haberfellner, Anita Prechtl, M.Di. Paolo, R. Wiborny, G. Wolf, A. Untch, W. Jaud, F. Jänicke, M. Zajc, A. Lohninger, Christine Kurz, Schadia Jinniate, Johannes Kunz, F. Gücer, H. Karras, R. Schulz-Wendtland, M. Untch, E. Abfalter, H. Salzer, D. Fuchs, M. Stöhrer, N. Vavra, J. Burkl, E. Schüren, M. Lange, D. Berg, W. Matal, A. Büttner, R. Höpfl, P. Voigt, Ulrike Heil, M. Putz, Ch. Dadak, G. Schönauer, K. Bihler, N. Harbeck, A. Schönwälder, B. Seelbach-Göbel, St. Schulz, M. Manavi, A. Rempen, A. Reinthaller, G. Kindermann, J. Stepien, W. Freidl, T. Dimpfl, H. Heidegger, R. Zeillinger, O. Wilhelm, G. Windbichler, H. Gründling, D. Löchner-Ernst, H. Hepp, W. Gruber, D. Kölle, H. Pickel, S. King, S. Wilhelm, S. Reindke, A. Hofstetter, G.J. Gerstner, W. Grünberger, T. Puchner, M. Saks, A. Staudach, M. Auer-Grumbach, Ch. Bieglmayer, M. Halaska, K. Swoboda, V. Möbus, K.-P Gloning, Ch. Dittrich, P. Dörffler, K. Klingenbeck, K. Baier, S. Müller-Reiter, M. Bühner, Ralph George, M. Batka, W. Schneider, M. Lahousen, R. Altrichter, A. Adler, W. Schroder, F. Ebner, W. Zeilmann, A. Schumitz, H. Helmer, A. Bittl, E. Greimel, H. Kiss, D. Möhrling, G. Häusler, U. Welscher, T. Genz, M. Wimbauer, L. Müller, H. Grebmeier, S. Todorow, H. Maurer, Ch. Kurz, Christine Sam, D. Egner, M. Dostert, E. Hafner, I. Stümpflen, H. Kaesemann, H. Wachter, H.-J. Semmelrock, H. Höfler, C. Marth, M. Korell, W. Schramm, P. Kastner, L. Wildt, L.C. Fuith, H.G. Sainz, H.K. Selbmann, S. Molnar, H. Caffier, W. Lechner, C. Nestle-Krämling, B.U. Sevin, C. Fidi, P. Weiss, E. Golob, R. Mai, R. Winter, R. Deckardt, B. Nakhla, E. Hanzal, O. Heiss, W. Würfel, S. Anthuber, K.F. Czerwenka, B. Bakker, P. Dettmar, E. Kind, J. Endl, St. Flachowsky, H. Auner, K. Heim, J. Egger, N. Lang, N.E. Adelwöhrer, J. Gnirs, P. Brandner, M. Löw, M. Schmitt, M. Zorzi, A.H. Tulusan, H. Janisch, C. Hellmich, H.-M. Böhm, N. Adelwöhrer, R. Kreienberg, K. Schuchter, J. Wortmann, G. Breitenecker, A.-H. Graf, V. Strnad, G. Quittan, N. Atanasov, M. Czarnecki, B. Wartusch, D. Kranzfelder, M. Neumann, A. Gold, L. Pache, Elisabeth Küffer, Ch. Schmid, M. Schumacher, K. Irsigler, M. Langer, J. Schmidt, E. Kubista, Eva Joura, T. Strowitzki, P.J. Albert, K.J. Neiss, H. Weidinger, W. Hönigl, K.T.M. Schneider, N Yamamoto, E. Müller-Holzner, W. Schemper, P.A.M. Weiss, Ch. Vutuc, Ch. Bali, A. Feiks, K. Fiedler, R. Kimmig, I. Funke, Beate Riedl, R. Knitza, Andrea Fink, J. Rehbock, H. Kraxner, H. Rauschecker, W. Loos, Liane Kunert, H.G. Bender, E. Wolner, J. Haas, A. Gedik, H. Prömer, C. Ploner-Strobl, D. Jelincic, I. Wilke, S. Jinniate, S. Leodolter, A. Riesselmann, G. Debus-Thiede, G. Meyberg, K.-Ph. Gloning, D. Weiss, G. Konecny, Kinga Chalubinski, P. Baumgartner, A. Zuckermann, E. Brusis, F. Gill, I. Müller-Hartburg, M. Ulm, F. Heuss, Dorrit Weiss, C. Klinger, Y. Lu, Nadia Harbeck, and P. Speiser

Subjects
Obstetrics and Gynecology, General Medicine
Published
1993
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12. Thrombozytensammlung mit dem A3p-Programm beim Blutzellseparator Haemonetics MCS3p

Author

Marcella C.A. Müller, K.-H. Schütt†, K. Widhalm, J.M. van der Linden, J. Kuchenbecker, S. Kohl, M.H.J. Molijn, Yi Zhang, H. Bernasconi, Pg. Höher, L. Urbin, M. Pietsch, M. Suttorp, S. Töre, A. Hammerle, M. Oberhauser, D.J. van Rhenen, J. Gorgels, M.G. Wichmann, L. Gürtler, J. Neppert, T. Haferlach, U. Kreimeier, T. Genz, L.K. Ko, and H.J. Bardenheuer

Subjects
Immunology and Allergy, Hematology
Published
1996
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13. Prognosefaktoren des nodalnegativen Mammakarzinoms

Author

B. Lampe, T. Dimpfl, and T. Genz

Subjects
Oncology, medicine.medical_specialty, Breast cancer, Text mining, business.industry, Internal medicine, medicine, Obstetrics and Gynecology, General Medicine, medicine.disease, business, Node negative
Published
1993
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14. Hypophysäre/Ovarielle Wirkstoffe

Author

R. Goebel, E. Kaiser, E. -G. Loch, W. Mestwerdt, O. Müller, J. S. E. Dericks-Tan, K. Schneider, H. -D. Taubert, H. Brandau, K. Regnant, R. Trolp, M. Breckwoldt, A. Hoff, H. Geyer, G. Gregorio, G. Lernbecher, L. Mettler, K. Semm, M. F. Engel, H. Schmidt-Elmendorff, H. Roll, K. Amann, Th. Holst, H. Junkermann, B. Runnebaum, J. Beyer, U. Krause, S. Nitschke-Dabelstein, G. Sturm, E. Daume, W. Geiger, D. Merkle, R. Berg, P. Rusch, G. Schwalb, T. Genz, J. Eiletz, K. Pollow, M. Schmidt-Gollwitzer, and F. Peters

Subjects
Gynecology, medicine.medical_specialty, business.industry, Obstetrics and Gynecology, Medicine, General Medicine, business, Human genetics
Published
1979
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15. A comparison between the results of simple mastectomy and tumorectomy for breast cancer: The problem of local recurrence

Author

T. Genz and G. Kindermann

Subjects
Clinical Trials as Topic, medicine.medical_specialty, business.industry, medicine.medical_treatment, General surgery, Lumpectomy, Obstetrics and Gynecology, Breast Neoplasms, General Medicine, medicine.disease, Combined Modality Therapy, Berlin, Radiation therapy, Simple mastectomy, Life Expectancy, Breast cancer, medicine, Retrospective analysis, Humans, Female, Neoplasm Recurrence, Local, business, Mastectomy, Retrospective Studies
Abstract

Between 1963 and 1981, 1139 patients had surgery for unilateral breast cancer at the Charlottenburg Gynaecological Clinic of the Free University Berlin. A total of 948 patients had a simple mastectomy and 191 patients had an extended tumorectomy (or lumpectomy) with subsequent radiotherapy (40 Gy). Retrospective analysis of "matched cases" treated by tumorectomy or mastectomy showed the rate of local recurrence after tumorectomy to be nearly double that after simple mastectomy (8.7% after tumorectomy, 4.7% after mastectomy). Life expectancy with a local recurrence after conservative surgery, was however, better than that after simple mastectomy.

Published
1985
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16. Diabetes mellitus: new therapeutic approaches to treat an old disease

Author

I. Gabanyi, G. B. Ferreira, R. C. Ferreira, P. B. Santos, M. P. Miranda, M. Andreolli, L. A. de Castro, E. Noda, D. Franco, A. C.V. Campos, E. M.C. Oliveira, M. Machado, D. Giannella- Neto, J. M. Granjeiro, S. M.S. Maria-Engler, M. L.C. Corrêa-Giannella, V. A. Fortuna, F. H. Lojudice, S. V. Sá, K. Krogh, L. Labriola, T. Genzini, I. L. Noronha, A. C. Goldberg, F. G. Eliaschewitz, and M. C. Sogayar

Subjects
Diabetes mellitus, cell and molecular therapy, human pancreatic islets, degenerative diseases, recombinant biopharmaceuticals, Pharmaceutical industry, HD9665-9675, Pharmacy and materia medica, RS1-441
Abstract

Diabetes mellitus is a widespread disease whose frequency increases constantly and is expected to reach alarming levels by the year 2025. Introduction of insulin therapy represented a major breakthrough; however, a very strict regimen is required to maintain blood glucose levels within the normal range and to prevent or postpone chronic complications associated with this disease. Frequent hyper- and hypoglycemia seriously affect the quality of life of these patients. Reversion of this situation can only be achieved through whole organ (pancreas) transplant or pancreatic islet transplant, the former being a high-risk surgical procedure, while the latter is a much simpler and may be accomplished in only 20-40 min. The advantages and perspectives of islet cell transplantation will be discussed, in the light of tissue engineering and gene therapy. Ongoing research carried out in our laboratory, aimed at developing clinical cell and molecular therapy protocols for diabetes will also be focused. Keywords: Diabetes mellitus, cell and molecular therapy, human pancreatic islets, degenerative diseases, recombinant biopharmaceuticals.

Published
2009

17. Microencapsulation and tissue engineering as an alternative treatment of diabetes

Author

S.S. Maria-Engler, M. Mares-Guia, M.L.C. Correa, E.M.C. Oliveira, C.A.M. Aita, K. Krogh, T. Genzini, M.P. Miranda, M. Ribeiro, L. Vilela, I.L. Noronha, F.G. Eliaschewitz, and M.C. Sogayar

Subjects
human pancreatic islets, pancreas, extracellular matrix, stem cells, islet microencapsulation, transplantation, ductal cells, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

In the 70's, pancreatic islet transplantation arose as an attractive alternative to restore normoglycemia; however, the scarcity of donors and difficulties with allotransplants, even under immunosuppressive treatment, greatly hampered the use of this alternative. Several materials and devices have been developed to circumvent the problem of islet rejection by the recipient, but, so far, none has proved to be totally effective. A major barrier to transpose is the highly organized islet architecture and its physical and chemical setting in the pancreatic parenchyma. In order to tackle this problem, we assembled a multidisciplinary team that has been working towards setting up the Human Pancreatic Islets Unit at the Chemistry Institute of the University of São Paulo, to collect and process pancreas from human donors, upon consent, in order to produce purified, viable and functional islets to be used in transplants. Collaboration with the private enterprise has allowed access to the latest developed biomaterials for islet encapsulation and immunoisolation. Reasoning that the natural islet microenvironment should be mimicked for optimum viability and function, we set out to isolate extracellular matrix components from human pancreas, not only for analytical purposes, but also to be used as supplementary components of encapsulating materials. A protocol was designed to routinely culture different pancreatic tissues (islets, parenchyma and ducts) in the presence of several pancreatic extracellular matrix components and peptide growth factors to enrich the beta cell population in vitro before transplantation into patients. In addition to representing a therapeutic promise, this initiative is an example of productive partnership between the medical and scientific sectors of the university and private enterprises.

Published
2001
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20. Erratum

Author

D. Reinhardt, O. Richter, T. Genz, and S. Potthoff

Subjects
Pediatrics, Perinatology and Child Health
Published
1982
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21. Aortic valvuloplasty in pediatric patients substantially postpones the need for aortic valve surgery: a single-center experience of 188 patients after up to 17.5 years of follow-up.

Author

Fratz S, Gildein HP, Balling G, Sebening W, Genz T, Eicken A, and Hess J

Subjects
Adolescent, Adult, Aortic Valve Stenosis epidemiology, Aortic Valve Stenosis surgery, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Survival Rate trends, Time, Aortic Valve pathology, Aortic Valve surgery, Aortic Valve Stenosis therapy, Catheterization trends, Heart Valve Prosthesis Implantation trends
Abstract

Background: Aortic valvuloplasty (AoVP) is an established procedure regarded as a valid alternative for surgical management of congenital aortic valve stenosis. However, its long-term efficacy in preventing or postponing aortic valve surgery remains uncertain for the individual patient. Therefore, the aim of this study was to study the long-term results of AoVP in pediatric patients and its efficacy in preventing or postponing aortic valve surgery., Methods and Results: We reviewed up to 17.5 years of follow-up data of all 188 patients who received AoVP at the Deutsches Herzzentrum München. The patients were divided into those < 1 month of age (group < 1 month; n=68) and those > or = 1 month of age (group > or = 1 month; n=120) at the time of AoVP. After the first and second AoVP, moderate and severe aortic regurgitation developed in 29% and 14%, respectively, of the patients in group < 1 month and in 19% and 29%, respectively, of the patients in group > or = 1 month. Survival after 10 years free from aortic valve surgery was 59% (95% confidence interval, 45 to 73) in group < 1 month and 70% (95% confidence interval, 59 to 81) in group > or = 1 month., Conclusions: This study shows that the long-term results of AoVP of congenital aortic valve stenosis in pediatric patients and its efficacy in preventing or postponing aortic valve surgery are very good. About two thirds of the patients are free from aortic valve surgery 10 years after AoVP.

Published
2008
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22. The fate of systemic blood pressure in patients after effectively stented coarctation.

Author

Eicken A, Pensl U, Sebening W, Hager A, Genz T, Schreiber C, Lang D, Kaemmerer H, Busch R, and Hess J

Subjects
Adolescent, Adult, Angioplasty, Balloon, Aortic Coarctation physiopathology, Blood Pressure physiology, Cardiac Catheterization statistics & numerical data, Child, Equipment Failure, Female, Humans, Long-Term Care, Male, Statistics, Nonparametric, Aortic Coarctation therapy, Hypertension therapy, Stents
Abstract

Aims: The current study was designed to assess midterm results of stent implantation into the aorta for native and recurrent coarctation (CoA) in children and young adults., Methods and Results: Forty-three patients (native CoA, 8; female, 12) were treated with stent implantation at a median age of 16.8 years (range 7.9-44.8 years). Only stents dilatable to an adult size aorta were implanted. All but two patients with functionally univentricular hearts had arterial hypertension. Exercise tests, 24-h blood pressure, clinical examination, echocardiography, and elective catheterization were used to assess follow-up. The narrowed segment was widened significantly from a median of 8 to 12.4 mm (P < 0.0005). The peak-to-peak gradient between the ascending and the descending aorta was lowered significantly from a median of 22 mmHg to 1 mmHg (P < 0.0005). No major complications occurred. The systolic blood pressure at the right arm was lowered significantly (P < 0.0005) from 144 mmHg before stent implantation to 128 mmHg at the last visit. At a median follow-up of 30 months (3-72 months), 68% of all patients were classified to be normotensive., Conclusion: Stent implantation for selected patients with recurrent and native CoA is safe and may effectively reduce the blood pressure gradient across the CoA site. We suggest using only stents dilatable to an adult size aorta. However, arterial hypertension persists in a significant number of the patients. Impaired elastic properties of the aorta may be the cause for this finding.

Published
2006
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23. Matched pair analysis of survival after chest-wall recurrence compared to mammary recurrence: a long-term follow up.

Author

Janni W, Shabani N, Dimpfl T, Starflinger I, Rjosk D, Peschers U, Bergauer F, Lampe B, and Genz T

Subjects
Analysis of Variance, Breast Neoplasms mortality, Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Matched-Pair Analysis, Middle Aged, Observer Variation, Prognosis, Proportional Hazards Models, Risk Factors, Survival Analysis, Time Factors, Treatment Outcome, Breast Neoplasms pathology, Breast Neoplasms surgery, Mastectomy methods, Neoplasm Recurrence, Local mortality, Skin Neoplasms secondary
Abstract

Background: Local recurrence remains a major concern after primary treatment of breast cancer and has a major impact on subsequent survival. While most studies report a poorer survival rate in patients with a local recurrence after mastectomy than after breast conservation, it remains controversial whether different risk profiles at the time of primary diagnosis may account for this difference., Method: Matched pair analysis of 134 patients with newly diagnosed locoregional recurrence of breast cancer without evidence of systemic disease. Matching criteria included the primary surgical treatment, tumor size, nodal status, and age. The significance of various prognostic parameters at the time of primary diagnosis and at the time of recurrence were evaluated, by univariate and multivariate analyses, with respect to survival after recurrence. The median follow-up was 8.4 years., Results: Risk factors at the time of presentation, such as tumor size and lymph node status, were comparable between both groups. Local recurrence occurred on an average 9 months earlier in patients after mastectomy (P = 0.08). Univariate analysis showed that lymph node status (P = 0.0001) and disease-free interval from primary treatment to local recurrence (P = 0.0002) were the most significant single prognostic factors for subsequent survival after local recurrence. The primary surgical treatment modality was shown to be of marginal statistical influence (only P = 0.05)., Conclusion: Local recurrence after mastectomy seems to be associated with worse survival than after breast-conserving therapy. Early onset of chest-wall recurrence, moreover, represents the highest independent risk for cancer-associated death.

Published
2001
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24. Correlation of c-erbB-2 protein expression with histologic grade, lymph node involvement and steroid receptor status in human breast tumors.

Author

Lampe B, Genz T, Maassen V, Mikorey S, and Klosterhalfen T

Subjects
Axilla, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Female, Humans, Lymph Nodes pathology, Prognosis, Receptor, ErbB-2, Receptors, Estrogen analysis, Receptors, Progesterone analysis, Biomarkers, Tumor analysis, Breast Neoplasms genetics, Carcinoma, Intraductal, Noninfiltrating genetics, Proto-Oncogene Proteins analysis
Abstract

The association of c-erbB-2 gene amplification product (p185) with histologic tumor type in 100 patients with primary breast cancer was determined. In 49 patients with infiltrating ductal carcinoma p185 detection was correlated with histologic findings (tumor grade, lymphnode status, receptor status). Strong positive staining for p185 protein was found in 10 patients (20%) with infiltrating ductal breast carcinoma and correlated with complete negative estrogen/progesterone receptor status and with histologic grade G3. There was neither an association with lymphnode involvement nor was there any to negative estrogen and progesterone receptor status alone. At present, we cannot say whether or not there is a correlation between the degree of c-erbB-2 gene amplification and prognosis. Follow-up studies are necessary to determine whether c-erbB-2 gene amplification allows definition of a specific subset of women who could benefit from adjuvant therapy.

Published
1992
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25. Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells.

Author

Pantel K, Schlimok G, Kutter D, Schaller G, Genz T, Wiebecke B, Backmann R, Funke I, and Riethmüller G

Subjects
Adenocarcinoma pathology, Breast Neoplasms pathology, Colon pathology, Down-Regulation, Humans, Neoplasm Metastasis, Stomach pathology, Adenocarcinoma immunology, Breast Neoplasms immunology, Colon immunology, Histocompatibility Antigens Class I metabolism, Stomach immunology
Abstract

An astoundingly high frequency of micrometastatic cells have been found in bone marrow aspirates of patients with colon carcinomas (G. Schlimok et al., J. Clin. Oncol., 8:831-837, 1990), although these tumors very rarely metastasize to the skeleton. This observation has raised questions about the malignant potential of such cells. In a first attempt to characterize this potential, we have assessed the expression of major histocompatibility complex (MHC) class I antigens on bone marrow micrometastases, inasmuch as down-regulation of these molecules is a potential mechanism to escape from MHC class I-restricted lysis by cytotoxic T-cells. The two groups of cancer patients compared were those with tumors known to rarely (stomach and colon cancer) or frequently (breast cancer) manifest skeleton metastases. Bone marrow aspirates taken from these patients were probed for individual disseminated tumor cells using the immunoalkaline phosphatase technique with monoclonal antibody CK2 to the epithelial differentiation antigen cytokeratin 18 (CK-18), as described previously (G. Schlimok et al., Proc. Natl. Acad. Sci. USA, 84:8672-8676, 1987). Specimens containing CK18-positive cells were colabeled with monoclonal antibody W6/32 directed to a framework (or nonpolymorphic) antigenic determinant of MHC class I heavy chains associated with beta 2-microglobulin. W6/32-positive CK-18-positive cells could be detected in 25 of 54 patients (46.3%) with significantly higher incidences in 26 breast cancer patients (61.9%) as compared to 28 patients with carcinomas of the stomach and colon (27.3 and 29.4%). Independent from the origin of the primary carcinoma, the incidence of W6/32-negative CK18-positive cells was positively correlated to both the differentiation grade of the primary tumor (P less than 0.05) and appeared to be linked to the occurrence of regional lymph node metastases (statistically not significant) determined by conventional histological examination. The present results demonstrate for the first time that down-regulation of MHC expression on individual micrometastatic cells correlates to the differential pattern of metastasis obtained by comparing breast and gastrointestinal carcinomas. This finding together with the suggestive link to clinical risk factors supports the significance of reduced MHC class I expression for the survival of residual metastatic cells which is a major determinant of prognosis for patients with solid tumors.

Published
1991

26. Classification of alpha1-antitrypsin (Pi) phenotypes by isoelectrofocusing. Distinction of six subtypes of the PiM phenotype.

Author

Genz T, Martin JP, and Cleve H

Subjects
Alleles, Gene Frequency, Germany, West, Humans, Isoelectric Focusing, Phenotype, alpha 1-Antitrypsin genetics
Abstract

Pi phenotypes have been determined by isoelectrofocusing in a sample of 538 healthy individuals from Southern Germany. Further subdivision of the common PiM phenotype is described. A procedure for the delineation of six common subtypes is presented. It is assumed that the six subtypes are determined by three alleles which are provisionally called PiMa, PiMb, and PiMc. Their frequencies in this sample were 0.75, 0.06, and 0.15, respectively.

Published
1977
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