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Although ICRF heating has achieved the high heating efficiency necessary to achieve high-performance plasmas, it has not overcome the reliability and economic problems associated with the antenna structure inside the vacuum vessel in fusion reactors. We suggested a slit ICRF antenna that uses the blanket surface as a transmission line to solve these problems. With a single slit ICRF antenna with a width of 3 m and a height of 15 cm, the electric field strength to the magnetic field direction was successfully suppressed to 5 kV/cm when 20 MW of power radiation was achieved from the single slit. The slit ICRF antenna had a bending angle in the electromagnetic wave transmission path to prevent direct neutron impact on the first wall and a vacuum gate from rapidly preventing water or air leakage accidents. The slit ICRF antenna has a simple structure that allows heating at high power density while minimizing blanket volume reduction.

Electron Cyclotron Resonance Heating (ECRH) has contributed to the achievement of high performance plasma production, high electron temperature plasmas and sustainment of steady-state plasmas in the Large Helical Device (LHD). Our immediate targets of upgrading the ECRH system are 5 MW several seconds and 1 MW longer than one hour power injection into LHD. The improvement will greatly extend the plasma parameter regime. For that purpose, we have been promoting the development and installation of 77 GHz/1-1.5 MW/several seconds and 0.3 MW/CW gyrotrons in collaboration with University of Tsukuba. The transmission lines are re-examined and improved for high and CW power transmission. In the recent experimental campaign, two 77 GHz gyrotrons were operated. One more gyrotron, which was designed for 1.5 MW/2 s output, was constructed and is tested. We have been promoting to improve total ECRH efficiency for efficient gyrotron-power use and efficient plasma heating, e.g. a new waveguide alignment method and mode-content analysis and the feedback control of the injection polarization. In the last experimental campaign, the 77 GHz gyrotrons were used in combination with the existing 84 GHz range and 168 GHz gyrotrons. Multi-frequency ECRH system is more flexible in plasma heating experiments and diagnostics. A lot of experiments have been performed in relation to high electron temperature plasmas by realization of the core electron-root confinement (CERC), electron cyclotron current drive (ECCD), Electron Bernstein Wave heating, and steady-state plasma sustainment. Some of the experimental results are briefly described. © 2009 American Institute of Physics.

The electron cyclotron resonance heating (ECRH) system on the Large Helical Device (LHD) has been in stable operation for ∼11 yr in numerous plasma experiments. During this time, many upgrades to the system have been made, such as reinforcement of the gyrotron tubes, modification of the power supply depending on gyrotron type, and increase in the number of transmission lines and antennas. These efforts allow the stable injection of millimeter-wave power in excess of 2 MW. In parallel, various transmission components were evaluated, and antenna performance was confirmed at a high power level. The coupling efficiency of the millimeter wave from the gyrotron to the transmission line and the transmission efficiency through the waveguide were further improved in recent years. The feedback control of the wave polarization has also been tried to maximize the efficiency of wave absorption. The gyrotron oscillation frequency was reconsidered in order to extend the flexibility of the magnetic configuration in plasma experiments. The development of 77-GHz gyrotrons with the output of 1 MW per few seconds in a single tube is currently taking place in collaboration with the University of Tsukuba. Two such gyrotron tubes already have been installed and were used for plasma experiments recently. An ECRH system with a capability of the steady operation is required, because the LHD can continuously generate confinement magnetic fields using superconducting magnets. Not only the gyrotron but also the transmission system and components must withstand continuous power operation. Further acceleration of both the power reinforcement and a steady-state capability will allow the sustainment of high-performance plasmas.

呼吸困難が出現し緊急手術にて救命しえた慢性特発性大腸偽性腸閉塞症の1例を経験したので報告する. 症例は60歳男性. 以前より便秘にて近医通院中であった. 腸閉塞症状が出現し近医入院, 保存的加療を行うも増悪するため当院緊急入院となった. 腹部は著明に膨満し, 腸雑音は消失していた. 徐々に内視鏡的ガス抜きを施行するも腹部膨満の増悪と呼吸障害が出現, 全身状態が悪化, 緊急手術を施行した. 大腸は盲腸から直腸まで著明に拡張し, とくにS状結腸に顕著であった. 大腸亜全摘術, 回腸人工肛門造設術を施行した. 術翌日には呼吸状態, 循環動態ともに改善し, 術後1年以上経過した現在特記すべき障害は認めていない.本症は腸管に器質的閉塞・狭窄や原因となる基礎疾患がないにもかかわらず, 大腸のみに腸閉塞様の症状を繰り返す疾患であるが, 保存的加療抵抗性の場合には外科的切除術も治療の選択肢の一つにあげるべきであると考えられた.

The potential of continuous plasma sustainment of Large Helical Device (LHD) was successfully demonstrated by a one hour discharge with 110 kW electron cyclotron heating (ECH) power. The ECH power of frequency 84 GHz generated by a continuous-work (CW) gyrotron is transmitted through an evacuated waveguide transmission line and injected to the LHD vacuum vessel using waveguide antenna. The plasma density was kept at about 1.5 × 1018/m3 and the electron temperature at the plasma center over 1 keV. Due to the low injection power the density was not so high but the plasma was quite stable. The power injection was terminated manually at 3900 seconds from the limitation of the setting of data acquisition, not for any troubles on devices.

Characteristics of MHD instabilities and their impacts on plasma confinement are studied in current free plasmas of the Large Helical Device. Spontaneous L?H transition is often observed in high beta plasmas close to 2% at low toroidal fields (Bt ? 0.75?T). The stored energy starts to rise rapidly just after the transition accompanying the clear rise in the electron density but quickly saturates due to the growth of the m = 2/n = 3 mode (m and n: poloidal and toroidal mode numbers), the rational surface of which is located in the edge barrier region, and edge localized mode (ELM) like activities having fairly small amplitude but high repetition frequency. Even in low beta plasmas without L?H transitions, ELM-like activities are sometimes induced in high performance plasmas with a steep edge pressure gradient and transiently reduce the stored energy up to 10%. Energetic ion driven MHD modes such as Alfv?n eigenmodes (AEs) are studied in a very wide range of characteristic parameters (the averaged beta of energetic ions, ?b?, and the ratio of energetic ion velocity to the Alfv?n velocity, Vb?/VA), of which range includes all tokamak data. In addition to the observation of toroidicity induced AEs (TAEs), coherent magnetic fluctuations of helicity induced AEs (HAEs) have been detected for the first time in NBI heated plasmas. The transition of a core-localized TAE to a global AE (GAE) is also observed in a discharge with temporal evolution of the rotational transform profile, having a similarity to the phenomenon observed in a reversed shear tokamak. At low magnetic fields, bursting TAEs transiently induce a significant loss of energetic ions, up to 40% of injected beams, but on the other hand play an important role in triggering the formation of transport barriers in the core and edge regions.

The experimentally optimized magnetic field configuration of the Large Helical Device [A. Iiyoshi et al., Nucl. Fusion 39, 1245 (1999)], where the magnetic axis is shifted inward by 15 cm from the early theoretical prediction, reveals 50% better global energy confinement than the prediction of the scaling law. This configuration has been investigated further from the viewpoints of high energy particle confinement and magnetohydrodynamic (MHD) stability. The confinement of high energy ions is improved as expected. The minority heating of ion cyclotron range of frequency was successful and the heating efficiency was improved by the inward shift. The confinement of passing particles by neutral beam injection was also improved under low magnetic field strength, and there could be obtained an almost steady high beta discharge up to 3% in volume average. This was a surprising result because the observed pressure gradient exceeded the Mercier unstable limit. The observed MHD activities became as high as beta but they did not grow enough to deteriorate the confinement of high energy ions or the performance of the bulk plasma, which was still 50% better than the scaling. According to these favorable results, better performance would be expected by increasing the heating power because the neoclassical transport can also be improved there.

Semiconductor detectors based on natural diamonds have been installed on the Large Helical Device (LHD) heliotron to measure the energy distribution of charge exchange fast neutral particles from different viewing angles. Advantages of a natural diamond detector (NDD) are (1) very compact size, (2) relatively easy handling, and (3) high energy resolution. Although NDDs are sensitive to visible light, vacuum ultraviolet, and soft x rays, unfavorable pulses produced by such radiation were greatly reduced by choosing an appropriate stainless steel shield in this experiment. In LHD, the time-resolved energy distribution of counter-going beam ions and ion cyclotron range of frequency-produced energetic ions have been successfully obtained by means of an NDD. The performance of NDDs as a neutral particle analyzer and its good suitability to LHD plasmas were demonstrated throughout this work.

Millimeter-wave components were re-examined for high power (Mega-Watt) and steady- state (greater than one hour) operation. Some millimeter-wave components, including waveguide joints, vacuum pumping sections, power monitors, sliding waveguides, and injection windows, have been improved for high power CW (Continuous Waves) transmission. To improve transmission efficiency, information about the wave phase and mode content of high power millimeter-waves propagating in corrugated waveguides, which are difficult to measure directly, were obtained by a newly developed method based on retrieved phase information. To optimize the plasma heating efficiency, a proof-of-principle study of the injection polarization feedback control was performed in the low power test stand.

In LHD, an ECH system for fusion-relevant plasma heating has been greatly progressed with the development of megawatt gyrotrons. Net power of 3.7 MW could be injected into LHD. For stable operation, a new position and profile monitor of the mmw-beams in evacuated transmission lines is developed. © 2010 IEEE.

Genes whose expression was up-regulated in low boron (B)-acclimated tobacco BY-2 (Nicotiana tabacum L. cv. Bright Yellow 2) cells, which had been selected under a low supply of B, were screened by the cDNA differential subtraction method. Thirteen genes were identified, including early salicylate-inducible glucosyltransferase, glutamine synthetase, glutathione S-transferase, and a pathogenesis-related protein, which might constitute a rescue system for oxidative damage. This indicates that B deficiency might impose cellular redox imbalance on the cells. Two of the 13 genes were induced within 30 min of B removal in the parent cells, indicating fast signal transfer from the cell walls to the cytoplasm.

The small GTPase Rho1 has been shown to regulate the organization of the actin cytoskeleton and formation of the cell wall in the fission yeast Schizosaccharomyces pombe. Activity of Rho1 must be precisely regulated in vivo, since both increases and decreases in its activity affect cell growth and shape. Thus, it is important to clarify the mechanism by which the activity of Rho1 is regulated in vivo.Seven genes encoding putative GAPs, GTPase-activating proteins, for the function of the Rho-family proteins were isolated from S. pombe. After disruption of these genes, rga1+ was found to play important roles in cell growth and morphogenesis. In rga1 null cells, delocalized F-actin patches and extraordinary thickening of the cell wall and the septum were observed. On the other hand, over-expression of Rga1 produced shrunken or dumpy cells. The phenotype of the rga1 null cells or the Rga1-over-expressing cells was similar to that of cells containing abnormally high or low Rho1 activity, respectively. Moreover, direct association of Rga1 with Rho1 was shown. Rga1 was localized to the cell ends and septum where Rho1 is known to function.In S. pombe, Rga1 is involved in the F-actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis, probably functioning as a GAP for the function of Rho1.

A long pulse discharge more than 2 minutes was achieved using Ion Cyclotron Range of Frequency (ICRF) heating only on the Large Helical Device (LHD). The final goal is a steady state operation (30 minutes) at MW level. A liquid stub tuner was newly invented to cope with the long pulse discharge. The liquid surface level was shifted under a high RF voltage operation without breakdown. In the long pulse discharge the reflected power was observed to gradually increase. The shift of the liquid surface was thought to be inevitably required at the further longer discharge. An ICRF heating system consisting of a liquid stub tuner was fabricated to demonstrate a feedback control impedance matching. The required shift of the liquid surface was predicted using a forward and a reflected RF powers as well as the phase difference between them. A liquid stub tuner was controlled by the multiprocessing computer system with CINOS (CHS Integration No Operating System) methods. The prime objective was to improve the performance of data processing and controlling a signal response. By employing this method a number of the program steps was remarkably reduced. A real time feedback control was demonstrated in the system using a temporally changed electric resistance.

Ion cyclotron range of frequency (ICRF) heating is currently in use on CHS and W7‐AS and is a major element of the heating planned for steady state helical devices. In helical devices, the lack of a toroidal current eliminates both disruptions and the need for ICRF current drive, simplifying the design of antenna structures as compared to tokamak applications. However the survivability of plasma facing components and steady state cooling issues are directly applicable to tokamak devices. Results from LHD steady state experiments should be available on a time scale to strongly influence the next generation of steady state tokamak experiments. The helical plasma geometry provides challenges not faced with tokamak ICRF heating, including the potential for enhanced fast ion losses, impurity accumulation, limited access for antenna structures, and open magnetic field lines in the plasma edge. The present results and near term plans provide the basis for steady state ICRF heating of larger helical devices. An a...

In six patients with advanced pancreatic carcinoma, TIL and tumour-draining lymphocytes (TDL) were isolated from primary pancreatic tumour and regional lymph nodes. In comparison with TDL and peripheral blood lymphocytes (PBL), TIL contained a comparatively higher percentage of TCR gamma delta+ cells, although they were still a small fraction. By 2 weeks culture with rIL-2 and immobilized OKT-3 antibody, the TCR gamma delta+ cells in TIL were preferentially expanded at the early culture periods, although it was temporary. In four cases, the TCR gamma delta+ and CD8+ TCR alpha beta+ TIL were separated by negative sorting using flowcytometry. All the TCR gamma delta+ TIL were CD4-, CD8- (double negative), and one of the TIL lines was mostly composed of delta TCS1+ cells, while the others were delta TCS1-. In comparison with CD8+ TCR alpha beta+ TIL, all the TCR gamma delta+ TIL exhibited much stronger lytic activity against freshly isolated autologous pancreatic cancer cells. However, all the gamma delta+ TIL also exhibited a strong non-MHC-restricted cytotoxicity, and there was no correlation between the lytic pattern and the percentage of delta TCS1+ cells. These data suggest that the TCR gamma delta+ T cells can proliferate vigorously in a certain condition, and if successfully expanded in vitro they might be helpful material for effective adoptive immunotherapy.

The collective Thomson scattering (CTS) technique has been utilized with the backscattering configuration in the collective scattering regime to diagnose the velocity distribution functions in the Large Helical Device (LHD). The receiver was equipped with 16 channels and the first test has been carried out using the eight channels for scattered radiation and these channels cover a few GHz frequency shift from the 76.95 GHz probe beam. During the discharge, the electron density and temperature at the central region of the LHD are 1×1019m−3, and 1.0 keV, respectively. The probing beam with rectangular wave modulation is injected by 50 Hz in order to be distinct from the background electron cyclotron emission (ECE). The scattered radiation is resolved successfully at each channel of CTS receiver system. The detected signals of bulk ion and electron components are by a factor of 10 ~ 102 larger than the background ECE signal. We found that the measured spectra are in reasonably agreement with the theoretical spectra calculated by using the reliable measured electron temperature and density for input parameters. The CTS receiver system will be improved to obtain more accurate velocity distributions in high temperature plasmas.

A new method is proposed to analyze the mode content of high power electromagnetic waves that are propagating through corrugated waveguides in the electron cyclotron resonance heating (ECH) systems for nuclear fusion devices. The method was applied to the 168 GHz transmission line of the ECH system in the Large Helical Device (LHD) to evaluate the waveguide alignment. The mode content of the propagating waves could be accurately analyzed using this method. Furthermore, the wave field in the waveguide was reconstructed using the mode content information obtained for each mode.

Ion cyclotron range of frequencies (ICRF) heating antennas in LHD are numerically simulated and analyzed by HFSSTM finite-element electromagnetic wave field calculation code. The model includes an accurate vacuum chamber wall of LHD and ICRF antenna structure and a simple model of plasma in a helical configuration. Antenna coupling with plasma is simulated by an artificial freshwater volume with enhanced high permittivity of e = 500-2000. RF current distribution and electromagnetic field distribution on and near the ICRF antenna are analyzed and well elucidated through a comparison with the experimental results. The frequency dependence of experimental loading resistance can be simulated by the calculation, and the RF dissipation on the antenna structure is studied and compared with experimental results. The local high heat load around gaps between the carbon side protectors is well explained, and the effect of gap distance is studied. Comparison with the experimental results reveals that the ICRF heating in the LHD, including the antenna and helical plasma, is well simulated by commercial HFSSTM code analysis. It will also be useful for future improvements in ICRF antenna design in helical devices.

Comprehensive genetic studies in which the genetic structure of a population is considered against the background of ecological factors, including environmental and social variables, often supply valuable information for the solution of a number of problems in human biology, including reproductive compensation and inbreeding depression. In the first section of this paper we consider the incidence of genetic diseases in Japan in reference to other populations. Some of the genetic disorders found elsewhere do not occur or are of lower frequencies in Japan. On the other hand, a number of genetic diseases occur at higher than usual frequencies, leading to an incidence of genetic disease of the order of about 1 per 100 in newborn Japanese. We next review the studies of consanguinity in Japan and report evidence of very high levels, ranging from 8.6% to 58.0%, for villages during the early part of the twentieth century. The rates are declining rapidly for the country but, because of traditional social values, inbreeding rates remain significant in many small villages. In the final section we consider the probable trends in the frequency of inbreeding on a worldwide basis and point out that frequencies of certain genetic diseases are likely to remain high and even increase in some societies because of various socially prescribed mating patterns.

A transition to a high electron temperature state in the core accompanied by an electron internal transport barrier (eITB) was clearly observed in neutral beam (NB) sustained plasmas with strongly focused on-axis electron cyclotron heating (ECH) in Large Helical Device (LHD). During stepwise injection of ECH power, the core electron temperature started to build up spontaneously and became high temperature in the core (high-Te state), while the temperature outside of ρ 0.3 drastically decreased. The transition dynamics of the core temperature is analyzed by the time evolution of electron temperature profiles and heat flux changes based on the data from multi-channel electron cyclotron emission. Effect of an initial island size (m/n=2/1) on the high-Te transition was experimentally investigated by controlling the width by an external coil field. The results show that the island size possibly affects a threshold value of ECH power and collisionality on the high-Te transition.

High-ion-temperature (exceeding 5 keV) hydrogen plasmas have been successfully produced in the Large Helical Device [Iiyoshi et al., Nucl. Fusion 39, 1245 (1999); Motojima et al., Nucl. Fusion 47, S668 (2007)] with the ion heat confinement improvement in the core region. The experimental ion heat diffusivity at the core region is found to be almost independent of the ion temperature, T_i (even decreasing as T_i increases). The neoclassical (NC) ripple transport is suppressed by the ambipolar radial electric field, E_r (

In the Large Helical Device, the stray microwave radiation is monitored by using so-called sniffer probes during electron cyclotron heating. In monitoring the stray radiation, we changed the microwave beam injection angle and search the O-X-B mode-conversion window to excite electron Bernstein waves (EBWs). When the microwave beam is injected toward the vicinity of the predicted O-X-B mode-conversion window, the electron temperature rises in the central part of overdense plasmas. In that case, the stray radiation level near the injection antenna becomes low. These results indicate that monitoring the stray radiation near the injection antenna is helpful in confirming the effectiveness of excitation of EBWs simply without precise analysis.

Achieving steady-state plasma operation at high plasma temperatures is one of the important goals of worldwide magnetic fusion research. A high temperature of approximately 2 keV, and steady-state plasma-sustainment operation of the Large Helical Device (LHD) [O. Motojima, K. Akaishi, H. Chikaraishi et al., Nucl. Fusion 40, 599 (2000)] is reported. High-temperature plasmas were created and maintained for more than 30 min with a world record injected heating power of 1.3 GJ. The three-dimensional heat-deposition profile of the LHD helical divertor was modified and during long-pulse discharges it effectively dispersed the heat load using a magnetic-axis swing technique developed at the LHD. A sweep of only 3 cm of the major radius of the magnetic axis position (less than 1% of the major radius of the LHD) was enough to disperse the divertor heat load. The modification of the heat-load profile was explained well by field-line tracing. The steady-state plasma was heated and sustained mainly by hydrogen minority ion heating using ion cyclotron range of frequencies. The operation lasted until a sudden increase of radiation loss occurred, presumably because of wall metal flakes dropping into the plasma. The sustained line-averaged electron density was approximately 0.7?0.8×10^19 m^?3. The average input power was 680 kW, and the plasma duration was 31 min 45 s. This successful long operation shows that the heliotron configuration has a high potential as a steady-state fusion reactor.

Particle control with pump limiters has been successfully demonstrated in a variety of tokamaks. This experiment has obtained, for the first time, experimental data on pump limiter operation in a heliotron configuration. A movable pump limiter module was installed on a horizontal midplane port of Heliotron-E. The limiter module was installed on a horizontal midplane port of Heliotron-E. The limiter assembly consists of a TiC-coated graphite head with single-sided particle collection and active pumping. The location of the limiter is varied from near the vacuum vessel wall or up to 8 cm inside the last closed magnetic flux surface. This flexibility permits the study of a heliotron plasma that is limited either by the magnetic separatrix or by a material limiter. In the configuration investigated, only very low pressures are observed in the pump limiter when it is located outside the last closed flux surface, indicating that the scrape-off layer density is very low ( 11 cm −3 ). For limiter positions inside the last closed flux surface, pressures of 2–6 mTorr are observed (similar to comparable tokamak operation). Erosion patterns on the vacuum vessel, as well as hot spots on the limiter head, indicate that the particle flow out of the confined plasma exhibits complicated patterns. This suggests that for efficient particle collection in a stellarator, pump limiters must be matched to the particle flow patterns.

Parametric studies of volume averaged electron temperature (Te) and global electron energy confinement time ?Ee of ohmically heated Heliotron E plasmas have been performed using a data acquisition computer system. The scaling laws (Te) ? (IOH · B/ne)0.5 and ?Ee ?ne-0.4 · B/IOH1.5 are obtained directly by a code which fits the exponents of the plasma parameters to the electron temperature and confinement time. The ohmically heated plasma confinement time ?Ee is shown to be related to the drift parameter ? (= VDe/VTe). The dependences of the energy confinement time on other plasma parameters is also presented. An investigation is made of the correlation between MHD activity and the confinement.