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4. Diagnostic Accuracy of the Initial Endoscopy for Ampullary Tumors

Author

Lee, Hee Seung, primary, Jang, Jong Soon, additional, Lee, Seungho, additional, Yeon, Myeong Ho, additional, Kim, Ki Bae, additional, Park, Jae Geun, additional, Lee, Joo Young, additional, Kim, Mi Jin, additional, Han, Joung-Ho, additional, Sung, Rohyun, additional, and Park, Seon Mee, additional

Published
2015
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6. Differential Expression of E-Cadherin, β-Catenin, and S100A4 in Intestinal Type and Nonintestinal Type Ampulla of Vater Cancers

Author

Sung, Rohyun, primary, Kang, Li, additional, Han, Joung-Ho, additional, Choi, Jae-Woon, additional, Lee, Sang Hwa, additional, Lee, Tae Hoon, additional, Park, Sang-Heum, additional, Kim, Hong Ja, additional, Lee, Eaum Seok, additional, Kim, Young Suk, additional, Choi, Young Woo, additional, and Park, Seon Mee, additional

Published
2014
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7. H2Receptor-Mediated Relaxation of Circular Smooth Muscle in Human Gastric Corpus: the Role of Nitric Oxide (NO)

Author

Lee, Sang Eok, primary, Kim, Dae Hoon, additional, Kim, Young Chul, additional, Han, Joung-Ho, additional, Choi, Woong, additional, Kim, Chan Hyung, additional, Jeong, Hye Won, additional, Park, Seon-Mee, additional, Yun, Sei Jin, additional, Choi, Song-Yi, additional, Sung, Rohyun, additional, Kim, Young Ho, additional, Yoo, Ra Young, additional, Sun, Park Hee, additional, Kim, Heon, additional, Song, Young-Jin, additional, Xu, Wen-Xie, additional, Yun, Hyo-Yung, additional, and Lee, Sang Jin, additional

Published
2014
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8. Combined aberrant expression of E-cadherin and S100A4, but not β-catenin is associated with disease-free survival and overall survival in colorectal cancer patients

Author

Lee, Sang-Jeon, primary, Choi, Song Yi, additional, Kim, Wun-Jae, additional, Ji, Meiying, additional, Lee, Taek-Gu, additional, Son, Bo-Ra, additional, Yoon, Soon Man, additional, Sung, Rohyun, additional, Lee, Eun Jeoung, additional, Youn, Sei Jin, additional, and Park, Seon Mee, additional

Published
2013
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10. Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

Author

Hong, Seung Hwa, primary, Sung, Rohyun, additional, Kim, Young Chul, additional, Suzuki, Hikaru, additional, Choi, Woong, additional, Park, Yeon Jin, additional, Ji, Ill Woon, additional, Kim, Chan Hyung, additional, Myung, Sun Chul, additional, Lee, Moo Yeol, additional, Kang, Tong Mook, additional, You, Ra Young, additional, Lee, Kwang Ju, additional, Lim, Seung Woon, additional, Yun, Hyo-Yung, additional, Song, Young-Jin, additional, Xu, Wen-Xie, additional, Kim, Hak Soon, additional, and Lee, Sang Jin, additional

Published
2013
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12. High K+-Induced Relaxation by Nitric Oxide in Human Gastric Fundus

Author

Kim, Dae Hoon, primary, Kim, Young Chul, additional, Choi, Woong, additional, Yun, Hyo-Young, additional, Sung, Rohyun, additional, Kim, Hun Sik, additional, Kim, Heon, additional, Yoo, Ra Young, additional, Park, Seon-Mee, additional, Yun, Sei Jin, additional, Song, Young-Jin, additional, Xu, Wen-Xie, additional, and Lee, Sang Jin, additional

Published
2012
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16. Regional Distribution of Interstitial Cells of Cajal (ICC) in Human Stomach

Author

Yun, Hyo-Yung, primary, Sung, Rohyun, additional, Kim, Young Chul, additional, Choi, Woong, additional, Kim, Hun Sik, additional, Kim, Heon, additional, Lee, Gwang Ju, additional, You, Ra Young, additional, Park, Seon-Mee, additional, Yun, Sei Jin, additional, Kim, Mi-Jung, additional, Kim, Won Seop, additional, Song, Young-Jin, additional, Xu, Wen-Xie, additional, and Lee, Sang Jin, additional

Published
2010
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18. Successful Hemostasis with Recombinant Activated Factor VII in a Patient with Massive Hepatic Subcapsular Hematoma

Author

Lee, Ju-Hee, primary, Chae, Hee Bok, additional, Seo, Eui-Keun, additional, Jeon, Won Joong, additional, Jeong, Hye Won, additional, Shin, Yoon Mi, additional, Bae, Jang Whan, additional, Kwon, Soon Kil, additional, Bae, Il Hun, additional, Shim, Woo Sub, additional, Shin, Dong Ick, additional, Sung, Rohyun, additional, and Kim, Ji Yoon, additional

Published
2009
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22. A Case of Idiopathic Adulthood Ductopenia

Author

Park, Byeong Chool, primary, Park, Seon Mee, additional, Choi, Eun Young, additional, Chae, Hee Bok, additional, Yoon, Se Jin, additional, Sung, Rohyun, additional, and Lee, Sung Koo, additional

Published
2009
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24. H2 Receptor-Mediated Relaxation of Circular Smooth Muscle in Human Gastric Corpus: the Role of Nitric Oxide (NO).

Author

Lee SE, Kim DH, Kim YC, Han JH, Choi W, Kim CH, Jeong HW, Park SM, Yun SJ, Choi SY, Sung R, Kim YH, Yoo RY, Sun PH, Kim H, Song YJ, Xu WX, Yun HY, and Lee SJ

Abstract

This study was designed to examine the effects of histamine on gastric motility and its specific receptor in the circular smooth muscle of the human gastric corpus. Histamine mainly produced tonic relaxation in a concentration-dependent and reversible manner, although histamine enhanced contractility in a minor portion of tissues tested. Histamine-induced tonic relaxation was nerve-insensitive because pretreatment with nerve blockers cocktail (NBC) did not inhibit relaxation. Additionally, K(+) channel blockers, such as tetraethylammonium (TEA), apamin (APA), and glibenclamide (Glib), had no effect. However, N(G)-nitro-L-arginine methyl ester (L-NAME) and 1H-(1,2,4)oxadiazolo (4,3-A) quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase (sGC), did inhibit histamine-induced tonic relaxation. In particular, histamine-induced tonic relaxation was converted to tonic contraction by pretreatment with L-NAME. Ranitidine, the H2 receptor blocker, inhibited histamine-induced tonic relaxation. These findings suggest that histamine produced relaxation in circular smooth muscle of human gastric smooth muscle through H2 receptor and NO/sGC pathways.

Published
2014
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25. Nitric Oxide-mediated Relaxation by High K in Human Gastric Longitudinal Smooth Muscle.

Author

Kim YC, Choi W, Yun HY, Sung R, Yoo RY, Park SM, Yun SJ, Kim MJ, Song YJ, Xu WX, and Lee SJ

Abstract

This study was designed to elucidate high-K(+)induced response of circular and longitudinal smooth muscle from human gastric corpus using isometric contraction. Contraction from circular and longitudinal muscle stripes of gastric corpus greater curvature and lesser curvature were compared. Circular smooth muscle from corpus greater curvature showed high K(+) (50 mM)-induced tonic contraction. On the contrary, however, longitudinal smooth muscle strips showed high K(+) (50 mM)-induced sustained relaxation. To find out the reason for the discrepancy we tested several relaxation mechanisms. Protein kinase blockers like KT5720, PKA inhibitor, and KT5823, PKG inhibitor, did not affect high K(+)-induced relaxation. K(+) channel blockers like tetraethylammonium (TEA), apamin (APA), glibenclamide (Glib) and barium (Ba(2+)) also had no effect. However, N(G)-nitro-L-arginine (L-NNA) and 1H-(1,2,4) oxadiazolo (4,3-A) quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase (sGC) and 4-AP (4-aminopyridine), voltage-dependent K(+) channel (K(V)) blocker, inhibited high K(+)-induced relaxation, hence reversing to tonic contraction. High K(+)-induced relaxation was observed in gastric corpus of human stomach, but only in the longitudinal muscles from greater curvature not lesser curvature. L-NNA, ODQ and K(V) channel blocker sensitive high K(+)-induced relaxation in longitudinal muscle of higher portion of corpus was also observed. These results suggest that longitudinal smooth muscle from greater curvature of gastric corpus produced high K(+)-induced relaxation which was activated by NO/sGC pathway and by K(V) channel dependent mechanism.

Published
2011
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