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2. Role and mechanism of PVN–sympathetic–adipose circuit in depression and insulin resistance induced by chronic stress

Author

Wang, Jing, primary, Sun, Linshan, additional, You, Jingjing, additional, Peng, Honghai, additional, Yan, Haijing, additional, Wang, Jiangong, additional, Sun, Fengjiao, additional, Cui, Minghu, additional, Wang, Sanwang, additional, Zhang, Zheng, additional, Fan, Xueli, additional, Liu, Dunjiang, additional, Liu, Cuilan, additional, Qiu, Changyun, additional, Chen, Chao, additional, Xu, Zhicheng, additional, Chen, Jinbo, additional, Li, Wei, additional, and Liu, Bin, additional

Published
2023
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8. Reactivating a positive feedback loop VTA-BLA-NAc circuit associated with positive experience ameliorates the attenuated reward sensitivity induced by chronic stress

Author

Sun, Linshan, primary, You, Jingjing, additional, Sun, Fengjiao, additional, Cui, Minghu, additional, Wang, Jiangong, additional, Wang, Wentao, additional, Wang, Dan, additional, Liu, Dunjiang, additional, Xu, Zhicheng, additional, Qiu, Changyun, additional, Liu, Bin, additional, and Yan, Haijing, additional

Published
2021
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9. Role of Adiponectin‐Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise

Author

You, Jingjing, primary, Sun, Linshan, additional, Wang, Jiangong, additional, Sun, Fengjiao, additional, Wang, Wentao, additional, Wang, Dan, additional, Fan, Xueli, additional, Liu, Dunjiang, additional, Xu, Zhicheng, additional, Qiu, Changyun, additional, Chen, Jinbo, additional, Yan, Haijing, additional, and Liu, Bin, additional

Published
2021
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11. Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease

Author

Wang, Jiangong, primary, Liu, Bin, additional, Xu, Yong, additional, Yang, Meizi, additional, Wang, Chaoyun, additional, Song, Mengmeng, additional, Liu, Jing, additional, Wang, Wentao, additional, You, Jingjing, additional, Sun, Fengjiao, additional, Wang, Dan, additional, Liu, Dunjiang, additional, and Yan, Haijing, additional

Published
2021
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18. Genomic and transcriptomic analyses reveal distinct biological functions for cold shock proteins (VpaCspA and VpaCspD) in Vibrio parahaemolyticus CHN25 during low-temperature survival

Author

Zhu, Chunhua, Sun, Boyi, Liu, Taigang, Zheng, Huajun, Gu, Wenyi, He, Wei, Sun, Fengjiao, Wang, Yaping, Yang, Meicheng, Bei, Weicheng, Peng, Xu, She, Qunxin, Xie, Lu, Chen, Lanming, Zhu, Chunhua, Sun, Boyi, Liu, Taigang, Zheng, Huajun, Gu, Wenyi, He, Wei, Sun, Fengjiao, Wang, Yaping, Yang, Meicheng, Bei, Weicheng, Peng, Xu, She, Qunxin, Xie, Lu, and Chen, Lanming

Abstract

Background: Vibrio parahaemolyticus causes serious seafood-borne gastroenteritis and death in humans. Raw seafood is often subjected to post-harvest processing and low-temperature storage. To date, very little information is available regarding the biological functions of cold shock proteins (CSPs) in the low-temperature survival of the bacterium. In this study, we determined the complete genome sequence of V. parahaemolyticus CHN25 (serotype: O5:KUT). The two main CSP-encoding genes (VpacspA and VpacspD) were deleted from the bacterial genome, and comparative transcriptomic analysis between the mutant and wild-type strains was performed to dissect the possible molecular mechanisms that underlie low-temperature adaptation by V. parahaemolyticus. Results: The 5,443,401-bp V. parahaemolyticus CHN25 genome (45.2% G + C) consisted of two circular chromosomes and three plasmids with 4,724 predicted protein-encoding genes. One dual-gene and two single-gene deletion mutants were generated for VpacspA and VpacspD by homologous recombination. The growth of the ΔVpacspA mutant was strongly inhibited at 10 °C, whereas the VpacspD gene deletion strongly stimulated bacterial growth at this low temperature compared with the wild-type strain. The complementary phenotypes were observed in the reverse mutants (ΔVpacspA-com, and ΔVpacspD-com). The transcriptome data revealed that 12.4% of the expressed genes in V. parahaemolyticus CHN25 were significantly altered in the ΔVpacspA mutant when it was grown at 10 °C. These included genes that were involved in amino acid degradation, secretion systems, sulphur metabolism and glycerophospholipid metabolism along with ATP-binding cassette transporters. However, a low temperature elicited significant expression changes for 10.0% of the genes in the ΔVpacspD mutant, including those involved in the phosphotransferase system and in the metabolism of nitrogen and amino acids. The major metabolic pathways that were altered by the dual-gene del

Published
2017

19. Genomic and transcriptomic analyses reveal distinct biological functions for cold shock proteins (VpaCspA and VpaCspD) in Vibrio parahaemolyticus CHN25 during low-temperature survival

Author

Zhu, Chunhua, primary, Sun, Boyi, additional, Liu, Taigang, additional, Zheng, Huajun, additional, Gu, Wenyi, additional, He, Wei, additional, Sun, Fengjiao, additional, Wang, Yaping, additional, Yang, Meicheng, additional, Bei, Weicheng, additional, Peng, Xu, additional, She, Qunxin, additional, Xie, Lu, additional, and Chen, Lanming, additional

Published
2017
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20. Comparison of Extracellular Proteins from Virulent and Avirulent Vibrio parahaemolyticusStrains to Identify Potential Virulence Factors

Author

He, Yu, Wang, Shuai, Yin, Xianting, Sun, Fengjiao, He, Bin, and Liu, Xiao

Abstract

Vibrioparahaemolyticusis a leading seafood-borne pathogen that causes gastroenteritis, septicemia, and serious wound infections due to the actions of virulence-associated proteins. We compared the extracellular proteins of nonvirulent JHY20 and virulent ATCC 33847 V. parahaemolyticusreference strains. Eighteen extracellular proteins were identified from secretory profiles, and 11 (68.75%) of the 16 proteins in ATCC 33847 are associated with virulence and/or protection against adverse conditions: trigger factor, chaperone SurA, aspartate–semialdehyde dehydrogenase, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, glutamate 5-kinase, alanine dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, outer membrane protein OmpV, ribosome-associated inhibitor A, chaperone protein Skp, and universal stress protein. Two nontoxic-related proteins, amino acid ABC transporter substrate-binding protein and an uncharacterized protein, were identified in JHY20. The results provide a theoretical basis for supporting safety risk assessment of aquatic foods, illuminate the pathogenic mechanisms of V. parahaemolyticus,and assist the identification of novel vaccine candidates for foodborne pathogens.

Published
2020
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22. Liver kinase B-1 modulates the activity of dopamine neurons in the ventral tegmental area and regulates social memory formation.

Author

Yu M, Sun F, Xiang G, Zhang Y, Wang X, Liu X, Huang B, Li X, and Zhang D

Abstract

Social memory is the ability to discriminate between familiar and unknown conspecifics. It is an important component of social cognition and is therefore essential for the establishment of social relationships. Although the neural circuit mechanisms underlying social memory encoding have been well investigated, little focus has been placed on the regulatory mechanisms of social memory processing. The dopaminergic system, originating from the midbrain ventral tegmental area (VTA), is a key modulator of cognitive function. This study aimed to illustrate its role in modulating social memory and explore the possible molecular mechanisms. Here, we show that the activation of VTA dopamine (DA) neurons is required for the formation, but not the retrieval, of social memory. Inhibition of VTA DA neurons before social interaction, but not 24 h after social interaction, significantly impaired social discrimination the following day. In addition, we showed that the activation of VTA DA neurons was regulated by the serine/threonine protein kinase liver kinase B1 (Lkb1). Deletion of Lkb1 in VTA DA neurons reduced the frequency of burst firing of dopaminergic neurons. Furthermore, Lkb1 plays an important role in regulating social behaviors. Both genetic and virus-mediated deletions of Lkb1 in the VTA of adult mice impaired social memory and subsequently attenuated social familiarization. Altogether, our results provide direct evidence linking social memory formation to the activation of VTA DA neurons in mice and illustrate the crucial role of Lkb1 in regulating VTA DA neuron function., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Yu, Sun, Xiang, Zhang, Wang, Liu, Huang, Li and Zhang.)

Published
2024
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23. Fuzi and Banxia Combination, Eighteen Antagonisms in Chinese Medicine, Aggravates Adriamycin-Induced Cardiomyopathy Associated with PKA/ β 2AR-Gs Signaling.

Author

Sun F, Huang Y, Li L, Yang C, Zhuang P, and Zhang Y

Abstract

Aconite Lateralis Radix Praeparata (Fuzi) and Pinelliae Rhizoma (Banxia) are a combination often used to treat cardiovascular diseases in ancient and modern clinical practice. However, eighteen antagonisms based on traditional Chinese medicine (TCM) theory often abided against such combination therapy. Therefore, exploring whether coadministration of the two herbs can be used in adriamycin- (ADR-) induced cardiomyopathy and clarifying the potential mechanism could help to guide its clinical application. Echocardiography experiments revealed that either Fuzi, Banxia, or their combination had effect on ADR-induced heart dysfunction, while high dose Fuzi exerted positive inotropic effect associated with restored PKA levels. Moreover, low dose Fuzi significantly reduced QT/QTc prolongation, inhibited cardiac apoptosis, and upregulated protein expression of PKA. However, combination of Fuzi and Banxia greatly aggravated QT/QTc prolongation and cardiomyocyte apoptosis in ADR rats compared with each drug alone, which was accompanied by a marked decrease in PKA, pSer346 levels. Similarly, Banxia alone treatment promoted cardiac apoptosis and downregulated protein levels of PKA and pSer346. Additionally, high dose Fuzi treatment also produced proapoptotic effect. Taken together, our study has provided the first direct evidence that combination of Fuzi, a positive inotropic agent, with Banxia promoted cardiac apoptosis in an ADR induced rat model of cardiomyopathy, which may be associated with suppression of PKA/ β 2AR-Gs signaling. This study also provides scientific language for better understanding of the risks and limitations of combination of Fuzi and Banxia in clinical applications.

Published
2018
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