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3 results on '"Suha Sayrac"'

1. Identification of a novel type of spacer element required for imprinting in fission yeast.

Author

Suha Sayrac, Sonya Vengrova, Emma L Godfrey, and Jacob Z Dalgaard

Subjects
Genetics, QH426-470
Abstract

Asymmetrical segregation of differentiated sister chromatids is thought to be important for cellular differentiation in higher eukaryotes. Similarly, in fission yeast, cellular differentiation involves the asymmetrical segregation of a chromosomal imprint. This imprint has been shown to consist of two ribonucleotides that are incorporated into the DNA during lagging-strand synthesis in response to a replication pause, but the underlying mechanism remains unknown. Here we present key novel discoveries important for unravelling this process. Our data show that cis-acting sequences within the mat1 cassette mediate pausing of replication forks at the proximity of the imprinting site, and the results suggest that this pause dictates specific priming at the position of imprinting in a sequence-independent manner. Also, we identify a novel type of cis-acting spacer region important for the imprinting process that affects where subsequent primers are put down after the replication fork is released from the pause. Thus, our data suggest that the imprint is formed by ligation of a not-fully-processed Okazaki fragment to the subsequent fragment. The presented work addresses how differentiated sister chromatids are established during DNA replication through the involvement of replication barriers.

Published
2011
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2. Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma

Author

Asli Bayindir, Suha Sayrac, Necat Yilmaz, Ozlem Giray, Deniz Turgut Coban, Esin Eren, Seçkin Özgür Tekeli, Hamit Yasar Ellidag, and Muhammet Kazim Erol

Subjects
Adult, Male, medicine.medical_specialty, genetic structures, Glaucoma, Blood lipids, Antioxidants, Blood serum, Internal medicine, Normal tension glaucoma, Hyperlipidemia, Medicine, Humans, High-Density Lipoprotein, Triglycerides, Aged, lcsh:R5-920, Polymorphism, Genetic, biology, business.industry, Aryldialkylphosphatase, Paraoxonase, General Medicine, Middle Aged, medicine.disease, Oxidants, PON1, Lipids, eye diseases, Oxidative Stress, Endocrinology, Cholesterol, Phenotype, Case-Control Studies, biology.protein, Female, Normal Tension Glaucoma, Pseudoexfoliative Glaucoma, business, lcsh:Medicine (General), Lipoproteins, HDL, Dyslipidemia, Research Article
Abstract

This study entailed a cross-examination of oxidant/antioxidant balance, high-density lipoprotein (HDL)-linked paraoxonase 1 (PON1) phenotypes, and levels of serum routine lipids among patients with normal tension glaucoma (NTG) or pseudoexfoliative glaucoma (PEXG) compared with healthy control groups. We aimed to investigate the links between oxidative stress (OS), HDL-related antioxidant enzyme activities and dyslipidemia in distinct subtypes of glaucoma. The study included 32 patients with NTG, 31 patients with PEXG, and 40 control subjects. Levels of PON1 and arylesterase enzymatic activity, total oxidant status (TOS), and total antioxidant status were measured by spectrophotometry and OS indexes (OSI) were calculated. The phenotype distribution of PON1 was determined using the dual substrate method. Blood serum levels of HDL, low-density lipoprotein, total cholesterol (TC), and triglyceride (TG) were measured. The TOS and OSI values in the NTG group were significantly higher compared with the other groups (both p < 0.01). The phenotype distribution found in the glaucoma and control groups were NTG: QQ, 59.4%; QR, 37.5%; RR, 3.1%; PEXG: QQ, 45.1%; QR, 48.4%; RR, 6.5%; and in the control group: QQ, 42.5%; QR, 50.0%; RR, 7.5%. Serum TC levels were significantly higher than the control in both NTG and PEXG groups, whereas TG was significantly higher in NTG only (p < 0.01 and p < 0.02, respectively). Hyperlipidemia, OS and variations in phenotype distribution of PON1 may play a role in the pathogenesis of different types of glaucoma.

Published
2015

3. Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine

Author

Hakan Emre Ozturk, Eda Suer, Suha Sayrac, Mustafa Turkoz, Akitoyo Ichinose, Elif Sarinay, Tsuyoshi Nagatake, and Kamruddin Ahmed

Subjects
pharynx, antibiotic resistance, penicillin resistance, Epithelial cells, medicine.disease_cause, Bacterial Adhesion, Mice, Medical microbiology, Pharmacology (medical), Respiratory system, Respiratory Tract Infections, Expectorants, adult, Carbocysteine, drug effect, article, Respiratory infection, musculoskeletal system, female, Infectious Diseases, Streptococcus pneumoniae, carbocisteine, Female, penicillin G, musculoskeletal diseases, Microbiology (medical), medicine.medical_specialty, respiratory tract infection, animal experiment, Virulence, macromolecular substances, minimum inhibitory concentration, Biology, S-Carboxymethylcysteine, Microbiology, male, medicine, Animals, Humans, controlled study, human, normal human, mouse, nonhuman, Mucolytic Agent, electron microscopy, animal model, bacterial virulence, human cell, technology, industry, and agriculture, Epithelial Cells, S-carboxymethylcysteine, biology.organism_classification, bacterium adherence, mortality, body regions, Immunology, Pharynx, epithelium cell, Bacteria
Abstract

S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria. © 2008 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.

Published
2008

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