1. Real-World Evidence on the Diagnostic and Clinical Characteristics of Asthma in Japanese Patients with COPD: The ACO Japan Cohort Study
- Author
-
Hashimoto,Shu, Yoshida,Yuri, Makita,Naoyuki, Sorimachi,Ryoko, Sugaya,Satoko, Arita,Yoshifumi, Hayashi,Nobuya, Tashiro,Naoki, Ichinose,Masakazu, Hashimoto,Shu, Yoshida,Yuri, Makita,Naoyuki, Sorimachi,Ryoko, Sugaya,Satoko, Arita,Yoshifumi, Hayashi,Nobuya, Tashiro,Naoki, and Ichinose,Masakazu
- Abstract
Shu Hashimoto1,2 ,â Yuri Yoshida,3 Naoyuki Makita,3 Ryoko Sorimachi,3 Satoko Sugaya,4 Yoshifumi Arita,3 Nobuya Hayashi,4 Naoki Tashiro,3 Masakazu Ichinose5,6 1Nihon University, Tokyo, Japan; 2Hibiya Kokusai Clinic, Tokyo, Japan; 3Medical Department, AstraZeneca K.K., Osaka, Japan; 4R&D, AstraZeneca K.K., Osaka, Japan; 5Academic Center of Osaki Citizen Hospital, Miyagi, Japan; 6Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japanâ Dr Shu Hashimoto passed away on July 03, 2022Correspondence: Masakazu Ichinose, Academic Center of Osaki Citizen Hospital, 3-8-1 Honami, Furukawa, Osaki, 989-6183, Japan, Tel +81-229-23-3311, Fax +81-229-23-5380, Email ichinose@h-osaki.jpIntroduction: The ACO Japan Cohort Study, a multicenter observational study, investigated the proportion of patients with chronic obstructive pulmonary disease (COPD) who met the Japanese Respiratory Society (JRS) asthmaâCOPD overlap (ACO) diagnostic criteria, characteristics of ACO and non-ACO patients, and the patient transitions between ACO/non-ACO diagnosis over 2 years.Patients and Methods: Patients with COPD were consecutively enrolled between June and December 2018 and followed up continuously for 2 years. All participating study sites were medical institutions where respiratory specialists routinely conducted medical examinations/tests required for ACO diagnosis.Results: Among 708 patients with COPD, 101 (14.3%), 118 (16.7%), and 125 (17.7%) were diagnosed with ACO at registration, 1 year, and 2 years, respectively. In total, 22.6% of patients lacked the data necessary for ACO diagnosis throughout the 2 years. Among patients who had the necessary data for ACO diagnosis, 24.7% were diagnosed with ACO at 2 years. More ACO patients had moderate or severe exacerbations in the past year than non-ACO patients at registration (15.8% vs 6.3%, p = 0.049) and 1 year (19.4% vs 7.6%, p = 0.025). ACO patients had a greater decrease in mean forced expiratory vo
- Published
- 2023