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12. Surgical reintervention on the neo-aorta after the Norwood operation

Author

Kido, Takashi, primary, Steringer, Maria-Theresa, additional, Heinisch, Paul Philipp, additional, Burri, Melchior, additional, Vodiskar, Janez, additional, Strbad, Martina, additional, Cleuziou, Julie, additional, Georgiev, Stanimir, additional, Lemmer, Julia, additional, Ewert, Peter, additional, Hager, Alfred, additional, Hörer, Jürgen, additional, and Ono, Masamichi, additional

Published
2022
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13. Clinical and haemodynamic variables associated with intensive care unit length of stay and early adverse outcomes after the Norwood procedure

Author

Staehler, Helena, primary, Ono, Masamichi, additional, Schober, Patrick, additional, Kido, Takashi, additional, Heinisch, Paul Philipp, additional, Strbad, Martina, additional, Vodiskar, Janez, additional, Cleuziou, Julie, additional, Lemmer, Julia, additional, Balling, Gunter, additional, Hager, Alfred, additional, Ewert, Peter, additional, and Hörer, Jürgen, additional

Published
2022
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14. Outcome after stage 1 palliation in non-hypoplastic left heart syndrome patients as a univentricular palliation.

Author

Schwarzbart, Carina, Burri, Melchior, Kido, Takashi, Heinisch, Paul Philipp, Vodiskar, Janez, Strbad, Martina, Cleuziou, Julie, Hager, Alfred, Ewert, Peter, Hörer, Jürgen, and Ono, Masamichi

Subjects
HYPOPLASTIC left heart syndrome, CARDIAC patients, PREMATURE labor, PULMONARY artery, VENTRICULAR dysfunction, INFANTS
Abstract

Open in new tab Download slide OBJECTIVES Studies focused on infants with univentricular heart undergoing stage I palliation other than the Norwood procedure remain a topic of great interest. This study evaluated the outcome of infants who underwent systemic to pulmonary shunt (SPS) or pulmonary artery banding (PAB). METHODS Infants who underwent SPS or PAB as stage I palliation between 1994 and 2019 were included. Survival and late systemic ventricular function were evaluated. RESULTS Out of 242 patients, 188 underwent SPS (77.7%) and 54 PAB (22.3%). Main diagnosis included tricuspid atresia, unbalanced atrioventricular septal defects, double inlet left ventricles and single ventricles with other morphology. Thirty-eight patients died before stage II palliation (15.7%). Stage II palliation was performed in 182 patients (75.2%), and mortality between stages II and III was 11 (5.6%). Stage III palliation was performed in 160 (66.1%) patients. Survival at 1, 5 and 15 years after stage I procedure was 81.9, 77.1 and 76.2%, respectively, and similar between both procedures (P  = 0.97). Premature birth [ P  = 0.03, hazard ratio (HR) = 2.1], heterotaxy (P  = 0.006, HR = 2.4) and dominant right ventricle (P  = 0.015, HR = 2.2) were factors associated to mortality. Unbalanced atrioventricular septal defect (P  = 0.005, HR = 4.6) was a factor associated to systemic ventricular dysfunction. CONCLUSIONS In patients with univentricular heart who underwent SPS and PAB as stage I palliation, survival at 15 years was 76%, regardless of th chosen approach. Premature birth, heterotaxy and dominant right ventricle were associated to mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Atrioventricular valve regurgitation in patients undergoing total cavopulmonary connection: Impact of valve morphology and underlying mechanisms on survival and reintervention

Author

Ono, Masamichi, primary, Cleuziou, Julie, additional, Pabst von Ohain, Jelena, additional, Beran, Elisabeth, additional, Burri, Melchior, additional, Strbad, Martina, additional, Hager, Alfred, additional, Hörer, Jürgen, additional, Schreiber, Christian, additional, and Lange, Rüdiger, additional

Published
2018
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30. Clinical outcome following total cavopulmonary connection: a 20-year single-centre experience

Author

Ono, Masamichi, primary, Kasnar-Samprec, Jelena, additional, Hager, Alfred, additional, Cleuziou, Julie, additional, Burri, Melchior, additional, Langenbach, Constantin, additional, Callegari, Alessia, additional, Strbad, Martina, additional, Vogt, Manfred, additional, Hörer, Jürgen, additional, Schreiber, Christian, additional, and Lange, Rüdiger, additional

Published
2016
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32. Clinical outcome following total cavopulmonary connection: a 20-year single-centre experience.

Author

Masamichi Ono, Kasnar-Sampre, Jelena, Hager, Alfred, Cleuziou, Julie, Burri, Melchior, Langenbach, Constantin, Callegari, Alessia, Strbad, Martina, Vogt, Manfred, Hörerc, Jürgen, Schreiber, Christian, and Langea, Rüdiger

Subjects
PULMONARY artery diseases, ARRHYTHMIA, CARDIOPULMONARY system, LIVER diseases, BIOCHEMISTRY
Abstract

OBJECTIVES: This study aims to evaluate the clinical outcome following total cavopulmonary connection (TCPC) and to identify factors affecting early and late outcome. METHODS: Between May 1994 and March 2015, 434 patients underwent TCPC with 50 lateral tunnels and 374 extracardiac conduits. The clinical outcome, exercise capacity and liver examination results were retrospectively reviewed. RESULTS: Thirty-day survival was 98.2%, and the estimated survival rate at 15 years was 92.3%. Freedom from tachyarrhythmia at 15 years was 91.0%. Other late morbidities included bradyarrhythmia in 17, protein-losing enteropathy (PLE) in 15, thromboembolism in 3 and plastic bronchitis in 3 patients. At last follow-up, normal systemic ventricular function (ejection fraction >50%) was observed in 88.2%. Atrioventricular valve (AVV) regurgitation was mild or less in 90% of patients with systemic left ventricle, in 63% of those with systemic right ventricle and 58% of the patients with unbalanced atrioventricular septal defect or common inlet ventricles. Cardiopulmonary exercise capacity showed impaired peak oxygen uptake (71% of normal) in a sub-group of 120 patients at a mean of 9 years postoperatively. Biochemistry of 338 patients at last follow-up revealed a gamma-glutamyl transferase value beyond normal in 90 patients (26%), with a positive correlation between the level and the time after the initial operation (P < 0.01). Pre-TCPC high transpulmonary gradient emerged as a predictor for delayed hospital recovery (P = 0.002), late mortality (P = 0.016) and reoperation (P = 0.015) in multivariable analysis. CONCLUSIONS: Contemporary TCPC can be performed with low risk and provides excellent survival in the long-term. Classic morbidities of the original Fontan procedure, such as Fontan pathway revision, tachyarrhythmia and thromboembolism seem mitigated. However, exercise limitations, PLE and liver dysfunction remain an issue. AVV insufficiency and ventricular dysfunction are still a concern. [ABSTRACT FROM AUTHOR]

Published
2016
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