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2. Dissecting the respective roles of microbiota and host genetics in the susceptibility of Card9−/− mice to colitis.

Author

Danne, C., Lamas, B., Lavelle, A., Michel, M.-L., Da Costa, G., Pham, Hang-Phuong, Lefevre, A., Bridonneau, C., Bredon, M., Planchais, J., Straube, M., Emond, P., Langella, P., and Sokol, H.

Subjects
GENETICS, INFLAMMATORY bowel diseases, COLITIS, GUT microbiome, GENE expression
Abstract

Background: The etiology of inflammatory bowel disease (IBD) is unclear but involves both genetics and environmental factors, including the gut microbiota. Indeed, exacerbated activation of the gastrointestinal immune system toward the gut microbiota occurs in genetically susceptible hosts and under the influence of the environment. For instance, a majority of IBD susceptibility loci lie within genes involved in immune responses, such as caspase recruitment domain member 9 (Card9). However, the relative impacts of genotype versus microbiota on colitis susceptibility in the context of CARD9 deficiency remain unknown. Results: Card9 gene directly contributes to recovery from dextran sodium sulfate (DSS)-induced colitis by inducing the colonic expression of the cytokine IL-22 and the antimicrobial peptides Reg3β and Reg3γ independently of the microbiota. On the other hand, Card9 is required for regulating the microbiota capacity to produce AhR ligands, which leads to the production of IL-22 in the colon, promoting recovery after colitis. In addition, cross-fostering experiments showed that 5 weeks after weaning, the microbiota transmitted from the nursing mother before weaning had a stronger impact on the tryptophan metabolism of the pups than the pups' own genotype. Conclusions: These results show the role of CARD9 and its effector IL-22 in mediating recovery from DSS-induced colitis in both microbiota-independent and microbiota-dependent manners. Card9 genotype modulates the microbiota metabolic capacity to produce AhR ligands, but this effect can be overridden by the implantation of a WT or "healthy" microbiota before weaning. It highlights the importance of the weaning reaction occurring between the immune system and microbiota for host metabolism and immune functions throughout life. A better understanding of the impact of genetics on microbiota metabolism is key to developing efficient therapeutic strategies for patients suffering from complex inflammatory disorders. -8ZHpF322gum1G2x3b5Gvy Video Abstract [ABSTRACT FROM AUTHOR]

Published
2024
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3. The potential of Λ and Ξ- studies with PANDA at FAIR

Author

Barucca, G., Davi, F., Lancioni, G., Mengucci, P., Montalto, L., Natali, P. P., Paone, N., Rinaldi, D., Scalise, L., Erni, W., Krusche, B., Steinacher, M., Walford, N., Cao, N., Liu, Z., Liu, C., Liu, B., Shen, X., Sun, S., Tao, J., Xiong, X. A., Zhao, G., Zhao, J., Albrecht, M., Alkakhi, W., Bokelmann, S., Feldbauer, F., Fink, M., Frech, J., Freudenreich, V., Fritsch, M., Hagdorn, R., Heinsius, F. H., Held, T., Holtmann, T., Keshk, I., Koch, H., Kopf, B., Kuhlmann, M., Kummel, M., Kussner, M., Li, J., Mustafa, A., Pelizaus, M., Pitka, A., Reher, J., Reicherz, G., Richter, M., Schnier, C., Sohl, L., Steinke, M., Triffterer, T., Wenzel, C., Wiedner, U., Denizli, H., Er, N., Beck, R., Hammann, C., Hartmann, J., Ketzer, B., Mullers, J., Rossbach, M., Salisbury, B., Schmidt, C., Thoma, U., Urban, M., Bianconi, A., Bragadireanu, M., Pantea, D., Domagala, M., Filo, G., Lisowski, E., Lisowski, F., Michalek, M., Poznanski, P., Plazek, J., Korcyl, K., Kozela, A., Lebiedowicz, P., Pysz, K., Schafer, W., Szczurek, A., Fiutowski, T., Idzik, M., Swientek, K., Terlecki, P., Korcyl, G., Lalik, R., Malige, A., Moskal, P., Nowakowski, K., Przygoda, W., Rathod, N., Rudy, Z., Salabura, P., Smyrski, J., Augustin, I., Bohm, R., Lehmann, I., Schmitt, L., Varentsov, V., Al-Turany, M., Belias, A., Deppe, H., Dzhygadlo, R., Flemming, H., Gerhardt, A., Gotzen, K., Heinz, A., Jiang, P., Karabowicz, R., Koch, S., Kurilla, U., Lehmann, D., Luhning, J., Lynen, U., Orth, H., Peters, K., Rieger, J., Saito, T., Schepers, G., Schmidt, C. J., Schwarz, C., Schwiening, J., Taschner, A., Traxler, M., Voss, B., Wieczorek, P., Abazov, V., Alexeev, G., Arefiev, V. A., Astakhov, V., Barabanov, M. Y., Batyunya, B. V., Dodokhov, V. K., Efremov, A., Fechtchenko, A., Galoyan, A., Golovanov, G., Koshurnikov, E. K., Lobanov, Y. Y., Olshevskiy, A. G., Piskun, A. A., Samartsev, A., Shimanski, S., Skachkov, N. B., Skachkova, A. N., Strokovsky, E. A., Tokmenin, V., Uzhinsky, V., Verkheev, A., Vodopianov, A., Zhuravlev, N. I., Branford, D., Watts, D., Bohm, M., Eyrich, W., Lehmann, A., Miehling, D., Pfaffinger, M., Quin, N., Robison, L., Seth, K., Xiao, T., Bettoni, D., Ali, A., Hamdi, A., Himmelreich, M., Krebs, M., Nakhoul, S., Nerling, F., Belousov, A., Kisel, I., Kozlov, G., Pugach, M., Zyzak, M., Bianchi, N., Gianotti, P., Lucherini, V., Bracco, G., Bettner, Y., Bodenschatz, S., Brinkmann, K. T., Bruck, L., Diehl, S., Dormenev, V., Duren, M., Erlen, T., Fohl, K., Hahn, C., Hayrapetyan, A., Hofmann, J., Kegel, S., Kesselkaul, M., Koseoglu, I., Kripko, A., Kuhn, W., Lange, J. S., Metag, V., Moritz, M., Nanova, M., Novotny, R., Orsich, P., Pereira-de-Lira, J., Peter, M., Sachs, M., Schmidt, M., Schubert, R., Stenzel, H., Straube, M., Strickert, M., Thoring, U., Wasem, T., Wohlfahrt, B., Zaunick, H. G., Tomasi-Gustafsson, E., Glazier, D., Ireland, D., Seitz, B., Deepak, P. N., Kulkarni, A., Kappert, R., Kavatsyuk, M., Loehner, H., Messchendorp, J., Rodin, V., Schakel, P., Vejdani, S., Dutta, K., Kalita, K., Huang, G., Liu, D., Peng, H., Qi, H., Sun, Y., Zhou, X., Kunze, M., Azizi, K., Derichs, A., Dosdall, R., Esmail, W., Gillitzer, A., Goldenbaum, F., Grunwald, D., Jokhovets, L., Kannika, J., Kulessa, P., Orfanitski, S., Perez Andrade, G., Prasuhn, D., Prencipe, E., Putz, J., Ritman, J., Rosenthal, E., Schadmand, S., Schmitz, R., Scholl, A., Sefzick, T., Serdyuk, V., Stockmanns, T., Veretennikov, D., Wintz, P., Wustner, P., Xu, H., Zhou, Y., Cao, X., Hu, Q., Li, Z., Li, H., Liang, Y., Ma, X., Rigato, V., Isaksson, L., Achenbach, P., Aycock, A., Corell, O., Denig, A., Distler, M., Hoek, M., Lauth, W., Leithoff, H. H., Merkel, H., Muller, U., Pochodzalla, J., Schlimme, S., Sfienti, C., Thiel, M., Zambrana, M., Ahmed, S., Bleser, S., Bolting, M., Capozza, L., Dbeyssi, A., Ehret, A., Grasemann, P., Klasen, R., Kliemt, R., Maas, F., Maldaner, S., Morales Morales, C., Motzko, C., Noll, O., Pfluger, S., Rodriguez Pineiro, D., Schupp, F., Steinen, M., Wolff, S., Zimmermann, I., Fedorov, A., Kazlou, D., Korzhik, M., Missevitch, O., Balashoff, A., Boukharov, A., Malyshev, O., Balanutsa, P., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Golubev, A., Goryachev, V., Kantsyrev, A., Kirin, D. Y., Kristi, N., Ladygina, E., Luschevskaya, E., Matveev, V. A., Panjushkin, V., Stavinskiy, A. V., Basant, K. N., Kumawat, H., Roy, B., Saxena, A., Yogesh, S., Bonaventura, D., Brand, P., Fritzsch, C., Grieser, S., Hargens, C., Hergemoller, A. K., Hetz, B., Husken, N., Kellers, J., Khoukaz, A., Bumrungkoh, D., Herold, C., Khosonthongkee, K., Kobdaj, C., Limphirat, A., Manasatitpong, K., Nasawad, T., Pongampai, S., Simantathammakul, T., Srisawad, P., Wongprachanukul, N., Yan, Y., Yu, C., Zhang, X., Zhu, W., Blinov, A. E., Kononov, S., Kravchenko, E. A., Antokhin, E., Barnyakov, A. Y., Beloborodov, K., Blinov, V. E., Kuyanov, I. A., Pivovarov, S., Pyata, E., Tikhonov, Y., Kunne, R., Ramstein, B., Hunter, G., Lattery, M., Pace, H., Boca, G., Duda, D., Finger, M., Finger, Jr, M., Kveton, A., Pesek, M., Peskova, M., Prochazka, I., Slunecka, M., Volf, M., Gallus, P., Jary, V., Korchak, O., Marcisovsky, M., Neue, G., Novy, J., Tomasek, L., Tomasek, M., Virius, M., Vrba, V., Abramov, V., Bukreeva, S., Chernichenko, S., Derevschikov, A., Ferapontov, V., Goncharenko, Y., Levin, A., Maslova, E., Melnik, Y., Meschanin, A., Minaev, N., Mochalov, V., Moiseev, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Roy, U., Yabsley, B., Belostotski, S., Fedotov, G., Gavrilov, G., Izotov, A., Manaenkov, S., Miklukho, O., Zhdanov, A., Atac, A., Back, T., Cederwall, B., Makonyi, K., Preston, M., Tegner, P. E., Wolbing, D., Gandhi, K., Rai, A. K., Godre, S., Crede, V., Dobbs, S., Eugenio, P., Lersch, D., Calvo, D., De Remigis, P., Filippi, A., Mazza, G., Rivetti, A., Wheadon, R., Bussa, M. P., Spataro, S., Iazzi, F., Lavagno, A., Martin, A., Akram, A., Calen, H., Ikegami Andersson, W., Johansson, T., Kupsc, A., Marciniewski, P., Papenbrock, M., Regina, J., Schonning, K., Wolke, M., Diaz, J., Pothodi Chackara, V., Chlopik, A., Kesik, G., Melnychuk, D., Tarasiuk, J., Wojciechowski, M., Wronka, S., Zwieglinski, B., Amsler, C., Buhler, P., Kratochwil, N., Marton, J., Nalti, W., Steinschaden, D., Widmann, E., Zimmermann, S., Zmeskal, J., Nuclear Energy, and Research unit Nuclear & Hadron Physics

Subjects
Nuclear Experiment
Abstract

The antiproton experiment PANDA at FAIR is designed to bring hadron physics to a new level in terms of scope, precision and accuracy. In this work, its unique capability for studies of hyperons is outlined. We discuss ground-state hyperons as diagnostic tools to study non-perturbative aspects of the strong interaction, and fundamental symmetries. New simulation studies have been carried out for two benchmark hyperon-antihyperon production channels: p¯ p→ Λ¯ Λ and p¯ p→ Ξ¯ +Ξ-. The results, presented in detail in this paper, show that hyperon-antihyperon pairs from these reactions can be exclusively reconstructed with high efficiency and very low background contamination. In addition, the polarisation and spin correlations have been studied, exploiting the weak, self-analysing decay of hyperons and antihyperons. Two independent approaches to the finite efficiency have been applied and evaluated: one standard multidimensional efficiency correction approach, and one efficiency independent approach. The applicability of the latter was thoroughly evaluated for all channels, beam momenta and observables. The standard method yields good results in all cases, and shows that spin observables can be studied with high precision and accuracy already in the first phase of data taking with PANDA.

Published
2021

4. Feasibility studies for the measurement of time-like proton electromagnetic form factors from $\bar{p}p \rightarrow \mu ^+\mu ^-$ at $\overline{\text {P}}\text {ANDA}$ at FAIR

Author

Barucca, G., Davì, F., Lancioni, G., Mengucci, P., Montalto, L., Natali, P.P., Paone, N., Rinaldi, D., Scalise, L., Erni, W., Krusche, B., Steinacher, M., Walford, N., Cao, N., Liu, C., Liu, B., Shen, X., Sun, S., Tao, J., Xiong, X.A., Zhao, Gang, Zhao, J., Albrecht, M., Alkakhi, W., Bökelmann, S., Feldbauer, F., Fink, M., Frech, J., Freudenreich, V., Fritsch, M., Hagdorn, R., Heinsius, F.H., Held, T., Holtmann, T., Keshk, I., Koch, H., Kopf, B., Kuhlmann, M., Kümmel, M., Küssner, M., Mustafa, A., Pelizäus, M., Pitka, A., Reher, J., Reicherz, G., Richter, M., Schnier, C., Sohl, L., Steinke, M., Triffterer, T., Wenzel, C., Wiedner, U., Denizli, H., Er, N., Keskin, U., Olgun, A.T., Yerlikaya, S., Yilmaz, A., Beck, R., Hammann, C., Hartmann, J., Ketzer, B., Müllers, J., Rossbach, M., Salisbury, B., Thoma, U., Urban, M., Bianconi, A., Bragadireanu, M., Pantea, D., Domagala, M., Filo, G., Lisowski, E., Lisowski, F., Michałek, M., Poznański, P., Płażek, J., Korcyl, K., Kozela, A., Lebiedowicz, P., Pysz, K., Schäfer, W., Szczurek, A., Fiutowski, T., Idzik, M., Swientek, K., Terlecki, P., Korcyl, G., Lalik, R., Malige, A., Moskal, P., Nowakowski, K., Przygoda, W., Rathod, N., Rudy, Z., Salabura, P., Smyrski, J., Augustin, I., Böhm, R., Lehmann, I., Schmitt, L., Varentsov, V., Al-Turany, M., Belias, A., Deppe, H., Dzhygadlo, R., Flemming, H., Gerhardt, A., Götzen, K., Heinz, A., Jiang, P., Karabowicz, R., Koch, S., Kurilla, U., Lehmann, D., Lühning, J., Lynen, U., Orth, H., Peters, K., Rieger, J., Saito, T., Schepers, G., Schmidt, C.J., Schwarz, C., Schwiening, J., Täschner, A., Traxler, M., Voss, B., Wieczorek, P., Abazov, V., Alexeev, G., Arefiev, V.A., Astakhov, V., Barabanov, M.Yu., Batyunya, B.V., Dodokhov, V.Kh., Efremov, A., Fechtchenko, A., Galoyan, A., Golovanov, G., Koshurnikov, E.K., Lobanov, Y.Yu., Olshevskiy, A.G., Piskun, A.A., Samartsev, A., Shimanski, S., Skachkov, N.B., Skachkova, A.N., Strokovsky, E.A., Tokmenin, V., Uzhinsky, V., Verkheev, A., Vodopianov, A., Zhuravlev, N.I., Branford, D., Watts, D., Böhm, M., Eyrich, W., Lehmann, A., Miehling, D., Pfaffinger, M., Quin, N., Robison, L., Seth, K., Xiao, T., Bettoni, D., Ali, A., Hamdi, A., Himmelreich, M., Krebs, M., Nakhoul, S., Nerling, F., Belousov, A., Kisel, I., Kozlov, G., Pugach, M., Zyzak, M., Bianchi, N., Gianotti, P., Lucherini, V., Bracco, G., Bettner, Y., Bodenschatz, S., Brinkmann, K.T., Brück, L., Diehl, S., Dormenev, V., Düren, M., Erlen, T., Föhl, K., Hahn, C., Hayrapetyan, A., Hofmann, J., Kegel, S., Kesselkaul, M., Köseoglu, I., Kripko, A., Kühn, W., Lange, J.S., Metag, V., Moritz, M., Nanova, M., Novotny, R., Orsich, P., Pereira-De-Lira, J., Peter, M., Sachs, M., Schmidt, M., Schubert, R., Stenzel, H., Straube, M., Strickert, M., Thöring, U., Wasem, T., Wohlfahrt, B., Zaunick, H.G., Tomasi-Gustafsson, E., Glazier, D., Ireland, D., Seitz, B., Deepak, P.N., Kulkarni, A., Kappert, R., Kavatsyuk, M., Loehner, H., Messchendorp, J., Rodin, V., Schakel, P., Vejdani, S., Dutta, K., Kalita, K., Huang, G., Liu, D., Peng, H., Qi, H., Sun, Y., Zhou, X., Kunze, M., Azizi, K., Bianchi, L., Derichs, A., Dosdall, R., Erven, A., Esmail, W., Gillitzer, A., Goldenbaum, F., Grunwald, D., Jokhovets, L., Kannika, J., Kulessa, P., Lai, A., Orfanitski, S., Andrade, G. Pérez, Prasuhn, D., Prencipe, E., Pütz, J., Ritman, J., Rosenthal, E., Schadmand, S., Schmitz, R., Scholl, A., Sefzick, T., Serdyuk, V., Sterzenbach, G., Stockmanns, T., Veretennikov, D., Wintz, P., Wüstner, P., Xu, H., Zhou, Y., Cao, X., Hu, Q., Li, Z., Li, H., Liang, Y., Ma, X., Rigato, V., Isaksson, L., Achenbach, P., Aycock, A., Corell, O., Denig, A., Distler, M., Hoek, M., Lauth, W., Leithoff, H.H., Liu, Z., Merkel, H., Müller, U., Pochodzalla, J., Schlimme, S., Sfienti, C., Thiel, M., Zambrana, M., Ahmed, S., Bleser, S., Bölting, M., Capozza, L., Dbeyssi, A., Ehret, A., Grasemann, P., Klasen, R., Kliemt, R., Maas, F., Maldaner, S., Morales, C. Morales, Motzko, C., Noll, O., Pflüger, S., Piñeiro, D. Rodríguez, Schupp, F., Steinen, M., Wolff, S., Zimmermann, I., Fedorov, A., Kazlou, D., Korzhik, M., Missevitch, O., Balanutsa, P., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Golubev, A., Goryachev, V., Kantsyrev, A., Kirin, D.Y., Kotov, A., Kristi, N., Ladygina, E., Luschevskaya, E., Matveev, V.A., Panjushkin, V., Stavinskiy, A.V., Balashoff, A., Boukharov, A., Malyshev, O., Basant, K.N., Kumawat, H., Roy, B., Saxena, A., Yogesh, S., Bonaventura, D., Brand, P., Fritzsch, C., Grieser, S., Hargens, C., Hergemöller, A.K., Hetz, B., Hüsken, N., Kellers, J., Khoukaz, A., Bumrungkoh, D., Herold, C., Khosonthongkee, K., Kobdaj, C., Limphirat, A., Manasatitpong, K., Nasawad, T., Pongampai, S., Simantathammakul, T., Srisawad, P., Wongprachanukul, N., Yan, Y., Yu, C., Zhang, X., Zhu, W., Blinov, A.E., Kononov, S., Kravchenko, E.A., Antokhin, E., Barnyakov, A.Yu., Beloborodov, K., Blinov, V.E., Kuyanov, I.A., Pivovarov, S., Pyata, E., Tikhonov, Y., Kunne, R., Ramstein, B., Hunter, G., Lattery, M., Pace, H., Boca, G., Duda, D., Finger, M., M.Finger, Jr., Kveton, A., Pesek, M., Peskova, M., Prochazka, I., Slunecka, M., Volf, M., Gallus, P., Jary, V., Korchak, O., Marcisovsky, M., Neue, G., Novy, J., Tomasek, L., Tomasek, M., Virius, M., Vrba, V., Abramov, V., Bukreeva, S., Chernichenko, S., Derevschikov, A., Ferapontov, V., Goncharenko, Y., Levin, A., Maslova, E., Melnik, Y., Meschanin, A., Minaev, N., Mochalov, V., Moiseev, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Roy, U., Yabsley, B., Belostotski, S., Fedotov, G., Gavrilov, G., Izotov, A., Manaenkov, S., Miklukho, O., Zhdanov, A., Atac, A., Bäck, T., Cederwall, B., Makonyi, K., Preston, M., Tegner, P.E., Wölbing, D., Gandhi, K., Rai, A.K., Godre, S., Crede, V., Dobbs, S., Eugenio, P., Lersch, D., Iazzi, F., Lavagno, A., Bussa, M.P., Spataro, S., Calvo, D., de Remigis, P., Filippi, A., Mazza, G., Rivetti, A., Wheadon, R., Martin, A., Akram, A., Calen, H., Andersson, W. Ikegami, Johansson, T., Kupsc, A., Marciniewski, P., Papenbrock, M., Regina, J., Schönning, K., Wolke, M., Diaz, J., Chackara, V. Pothodi, Chlopik, A., Kesik, G., Melnychuk, D., Tarasiuk, J., Wojciechowski, M., Wronka, S., Zwieglinski, B., Amsler, C., Bühler, P., Kratochwil, N., Marton, J., Nalti, W., Steinschaden, D., Suzuki, K., Widmann, E., Zimmermann, S., Zmeskal, J., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), PANDA, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
data analysis method, Nuclear and High Energy Physics, Particle physics, Proton, Monte Carlo method, Hadron, +muon%2B+muon%22">p anti-p --> muon+ muon, programming, 01 natural sciences, anti-p p: colliding beams, Momentum, Pion, statistical analysis, 0103 physical sciences, anti-p p: scattering, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Nuclear fusion, ddc:530, angular distribution, structure, anti-p: beam, 010306 general physics, Physics, Muon, background, 010308 nuclear & particles physics, PANDA, suppression, form factor: electromagnetic, muon: pair production, p: form factor, beam: momentum, numerical calculations: Monte Carlo, statistical, Bar (unit)
Abstract

The European physical journal / A 57(1), 30 (2021). doi:10.1140/epja/s10050-020-00333-3, Published by Springer, Heidelberg

Published
2021
Full Text
View/download PDF

5. Feasibility studies for the measurement of time-like proton electromagnetic form factors from $\bar{p}p\rightarrow \mu^{+}\mu^{-}$ at $\bar{P}ANDA$ at FAIR

Author

Barucca, G., Davì, F., Lancioni, G., Mengucci, P., Montalto, L., Natali, P. P., Paone, N., Rinaldi, D., Scalise, L., Erni, W., Krusche, B., Steinacher, M., Walford, N., Cao, N., Liu, Z., Liu, C., Liu, B., Shen, X., Sun, S., Tao, J., Xiong, X. A., Zhao, G., Zhao, J., Albrecht, M., Alkakhi, W., Bökelmann, S., Coen, S., Feldbauer, F., Fink, M., Frech, J., Freudenreich, V., Fritsch, M., Grochowski, J., Hagdorn, R., Heinsius, F. H., Held, T., Holtmann, T., Keshk, I., Koch, H., Kopf, B., Kuhlmann, M., Kümmel, M., Küßner, M., Li, J., Linzen, L., Maldaner, S., Oppotsch, J., Pankonin, S., Pelizäus, M., Pflüger, S., Pitka, A., Reher, J., Reicherz, G., Schnier, C., Steinke, M., Triffterer, T., Wenzel, C., Wiedner, U., Denizli, H., Er, N., Keskin, U., Olgun, A. T., Yerlikaya, S., Yilmaz, A., Beck, R., Hammann, C., Hartmann, J., Ketzer, B., Müllers, J., Rossbach, M., Salisbury, B., Schmidt, C., Thoma, U., Urban, M., Bianconi, A., Bragadireanu, M., Pantea, D., Domagala, M., Filo, G., Lisowski, E., Lisowski, F., Michałek, M., Poznański, P., Płażek, J., Korcyl, K., Kozela, A., Lebiedowicz, P., Pysz, K., Schäfer, W., Szczurek, A., Firlej, M., Fiutowski, T., Idzik, M., Moron, J., Swientek, K., Terlecki, P., Korcyl, Grzegorz, Lalik, Rafał, Malige, Akshay, Moskal, Paweł, Nowakowski, Krzysztof, Przygoda, Witold, Rathod, Narendra, Rudy, Zbigniew, Salabura, Piotr, Smyrski, Jerzy, Augustin, I., Böhm, R., Lehmann, I., Schmitt, L., Varentsov, V., Al-Turany, M., Belias, A., Deppe, H., Dzhygadlo, R., Flemming, H., Gerhardt, A., Götzen, K., Heinz, A., Jiang, P., Karabowicz, R., Koch, S., Kurilla, U., Lehmann, D., Lühning, J., Lynen, U., Orth, H., Peters, K., Saito, T., Schepers, G., Schmidt, C. J., Schwarz, C., Schwiening, J., Täschner, A., Traxler, M., Voss, B., Wieczorek, P., Abazov, V., Alexeev, G., Arefiev, V. A., Astakhov, V., Barabanov, M. Yu., Batyunya, B. V., Dodokhov, V. Kh., Efremov, A., Fechtchenko, A., Galoyan, A., Golovanov, G., Koshurnikov, E. K., Lobanov, Y. Yu., Olshevskiy, A. G., Piskun, A. A., Samartsev, A., Shimanski, S., Skachkov, N. B., Skachkova, A. N., Strokovsky, E. A., Tokmenin, V., Uzhinsky, V., Verkheev, A., Vodopianov, A., Zhuravlev, N. I., Branford, D., Watts, D., Böhm, M., Eyrich, W., Lehmann, A., Miehling, D., Pfaffinger, M., Quin, N., Robison, L., Seth, K., Xiao, T., Bettoni, D., Ali, A., Hamdi, A., Himmelreich, M., Krebs, M., Nakhoul, S., Nerling, F., Belousov, A., Kisel, I., Kozlov, G., Pugach, M., Zyzak, M., Bianchi, N., Gianotti, P., Lucherini, V., Bracco, G., Bettner, Y., Bodenschatz, S., Brinkmann, K. T., Brück, L., Diehl, S., Dormenev, V., Düren, M., Erlen, T., Föhl, K., Hahn, C., Hayrapetyan, A., Hofmann, J., Kegel, S., Kesselkaul, M., Köseoglu, I., Kripko, A., Kühn, W., Lange, J. S., Metag, V., Moritz, M., Nanova, M., Novotny, R., Orsich, P., Pereira-de-Lira, J., Peter, M., Sachs, M., Schmidt, M., Schubert, R., Stenzel, H., Straube, M., Strickert, M., Thöring, U., Wasem, T., Wohlfahrt, B., Zaunick, H. G., Tomasi-Gustafsson, E., Glazier, D., Ireland, D., Seitz, B., Deepak, P. N., Kulkarni, A., Kappert, R., Kavatsyuk, M., Loehner, H., Messchendorp, J., Rodin, V., Schakel, P., Vejdani, S., Dutta, K., Kalita, K., Huang, G., Liu, D., Peng, H., Qi, H., Sun, Y., Zhou, X., Kunze, M., Azizi, K., Tavukoglu, Z., Derichs, A., Dosdall, R., Esmail, W., Gillitzer, A., Goldenbaum, F., Grunwald, D., Jokhovets, L., Kannika, J., Kulessa, P., Orfanitski, S., Pérez Andrade, G., Prasuhn, D., Prencipe, E., Pütz, J., Ritman, J., Rosenthal, E., Schadmand, S., Schmitz, R., Scholl, A., Sefzick, T., Serdyuk, V., Stockmanns, T., Veretennikov, D., Wintz, P., Wüstner, P., Xu, H., Zhou, Y., Cao, X., Hu, Q., Li, Z., Li, H., Liang, Y., Ma, X., Rigato, V., Isaksson, L., Achenbach, P., Corell, O., Denig, A., Distler, M., Hoek, M., Lauth, W., Leithoff, H. H., Merkel, H., Müller, U., Pochodzalla, J., Schlimme, S., Sfienti, C., Thiel, M., Zambrana, M., Ahmed, S., Bleser, S., Bölting, M., Capozza, L., Dbeyssi, A., Ehret, A., Klasen, R., Kliemt, R., Maas, F., Motzko, C., Noll, O., Piñeiro, D. Rodríguez, Schupp, F., Steinen, M., Wolff, S., Zimmermann, I., Fedorov, A., Kazlou, D., Korzhik, M., Missevitch, O., Balanutsa, P., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Golubev, A., Goryachev, V., Kantsyrev, A., Kirin, D. Y., Kristi, N., Ladygina, E., Luschevskaya, E., Matveev, V. A., Panjushkin, V., Stavinskiy, A. V., Balashoff, A., Boukharov, A., Malyshev, O., Basant, K. N., Kumawat, H., Roy, B., Saxena, A., Yogesh, S., Bonaventura, D., Brand, P., Fritzsch, C., Grieser, S., Hargens, C., Hergemöller, A. K., Hetz, B., Hüsken, N., Kellers, J., Khoukaz, A., Mannweiler, C., Vestrick, S., Bumrungkoh, D., Herold, C., Khosonthongkee, K., Kobdaj, C., Limphirat, A., Manasatitpong, K., Nasawad, T., Pongampai, S., Simantathammakul, T., Srisawad, P., Wongprachanukul, N., Yan, Y., Yu, C., Zhang, X., Zhu, W., Blinov, A. E., Kononov, S., Kravchenko, E. A., Antokhin, E., Barnyakov, A. Yu., Beloborodov, K., Blinov, V. E., Kuyanov, I. A., Pivovarov, S., Pyata, E., Tikhonov, Y., Hunter, G., Lattery, M., Pace, H., Boca, G., Duda, D., Finger, M., Finger, Jr., M., Kveton, A., Pesek, M., Peskova, M., Prochazka, I., Slunecka, M., Volf, M., Gallus, P., Jary, V., Korchak, O., Marcisovsky, M., Neue, G., Novy, J., Tomasek, L., Tomasek, M., Virius, M., Vrba, V., Abramov, V., Bukreeva, S., Chernichenko, S., Derevschikov, A., Ferapontov, V., Goncharenko, Y., Levin, A., Maslova, E., Melnik, Y., Meschanin, A., Minaev, N., Mochalov, V., Moiseev, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Roy, U., Yabsley, B., Belostotski, S., Fedotov, G., Gavrilov, G., Izotov, A., Manaenkov, S., Miklukho, O., Zhdanov, A., Atac, A., Bäck, T., Cederwall, B., Makonyi, K., Preston, M., Tegner, P. E., Wölbing, D., Gandhi, K., Rai, A. K., Godre, S., Crede, V., Dobbs, S., Eugenio, P., Lersch, D., Calvo, D., De Remigis, P., Filippi, A., Mazza, G., Rivetti, A., Wheadon, R., Bussa, M. P., Spataro, S., Iazzi, F., Lavagno, A., Martin, A., Akram, A., Calen, H., Andersson, W. Ikegami, Johansson, T., Kupsc, A., Marciniewski, P., Papenbrock, M., Regina, J., Rieger, J., Schönning, K., Wolke, M., Pothodi Chackara, V., Chlopik, A., Kesik, G., Melnychuk, D., Tarasiuk, J., Wojciechowski, M., Wronka, S., Zwieglinski, B., Amsler, C., Bühler, P., Marton, J., Nalti, W., Steinschaden, D., Widmann, E., Zimmermann, S., and Zmeskal, J.

Published
2021

6. Feasibility studies for the measurement of time-like proton electromagnetic form factors from (p)over-barp -> mu(+)mu(-) at PANDA at FAIR

Author

Barucca, G., Davì, F., Krusche, B., Nowakowski, K., Przygoda, W., Rathod, N., Rudy, Z., Salabura, P., Smyrski, J., Augustin, I., Böhm, R., Lehmann, I., Schmitt, L., Steinacher, M., Varentsov, V., Al-Turany, M., Belias, A., Deppe, H., Dzhygadlo, Roman, Flemming, H., Gerhardt, A., Götzen, K., Heinz, A., Jiang, P., Walford, N., Karabowicz, R., Koch, S., Kurilla, U., Lehmann, D., Lühning, J., Lynen, U., Orth, H., Peters, K., Saito, Takahito, Schepers, G., Cao, N., Schmidt, C. J., Schwarz, C., Schwiening, J., Täschner, A., Traxler, M., Voss, B., Wieczorek, P., Abazov, V., Alexeev, G., Arefiev, V. A., Liu, Z., Astakhov, V., Barabanov, M. Yu., Batyunya, B. V., Dodokhov, V. Kh., Efremov, A., Fechtchenko, A., Galoyan, A., Golovanov, G., Koshurnikov, E. K., Lobanov, Y. Yu., Liu, C., Olshevskiy, A. G., Piskun, A. A., Samartsev, A., Shimanski, S., Skachkov, N. B., Skachkova, A. N., Strokovsky, E. A., Tokmenin, V., Uzhinsky, V., Verkheev, A., Liu, Bochao, Vodopianov, A., Zhuravlev, N. I., Branford, D., Watts, D., Böhm, M., Eyrich, W., Lehmann, A., Miehling, D., Pfaffinger, M., Quin, N., Shen, X., Robison, L., Seth, K., Xiao, T., Bettoni, D., Ali, A., Hamdi, A., Himmelreich, M., Krebs, Hermann, Nakhoul, S., Nerling, F., Sun, S., Belousov, A., Kisel, I., Kozlov, G., Pugach, M., Zyzak, M., Bianchi, N., Gianotti, P., Lucherini, V., Bracco, G., Bettner, Y., Tao, J., Bodenschatz, S., Brinkmann, K. T., Brück, L., Diehl, S., Dormenev, V., Düren, M., Erlen, T., Föhl, K., Hahn, C., Hayrapetyan, A., Lancioni, G., Xiong, Xiaonu, Hofmann, J., Kegel, S., Kesselkaul, M., Köseoglu, I., Kripko, A., Kühn, W., Lange, J. S., Metag, V., Moritz, M., Nanova, M., Zhao, G., Novotny, R., Orsich, P., Pereira-de-Lira, J., Peter, M., Sachs, M., Schmidt, Marvin, Schubert, R., Stenzel, H., Straube, M., Strickert, M., Zhao, Jing, Thöring, U., Wasem, T., Wohlfahrt, B., Zaunick, H. G., Tomasi-Gustafsson, E., Glazier, D., Ireland, D., Seitz, B., Deepak, P. N., Kulkarni, A., Albrecht, M., Kappert, R., Kavatsyuk, M., Loehner, H., Messchendorp, J., Rodin, V., Schakel, P., Vejdani, S., Dutta, K., Kalita, K., Huang, G., Alkakhi, W., Liu, D., Peng, H., Qi, H., Sun, Yajie, Zhou, X., Kunze, M., Azizi, K., Tavukoglu, Z., Derichs, A., Dosdall, R., Bökelmann, S., Esmail, W., Gillitzer, A., Goldenbaum, F., Grunwald, D., Jokhovets, L., Kannika, J., Kulessa, P., Orfanitski, S., Perez, Gabriela, Prasuhn, D., Coen, S., Prencipe, E., Pütz, Jennifer, Ritman, J., Rosenthal, E., Schadmand, S., Schmitz, Ralf, Scholl, A., Sefzick, T., Serdyuk, V., Stockmanns, T., Feldbauer, F., Veretennikov, D., Wintz, P., Wüstner, P., Xu, Huagen, Zhou, Yong, Cao, X., Hu, Q., Li, Z., Li, Haijian, Liang, Y., Fink, M., Ma, Xiaochen, Rigato, V., Isaksson, L., Achenbach, P., Corell, O., Denig, A., Distler, M., Hoek, M., Lauth, W., Leithoff, H. H., Frech, J., Merkel, H., Müller, U., Pochodzalla, J., Schlimme, S., Sfienti, C., Thiel, M., Zambrana, M., Ahmed, S., Bleser, S., Mengucci, P., Freudenreich, V., Bölting, M., Capozza, L., Dbeyssi, A., Ehret, A., Klasen, R., Kliemt, R., Maas, F., Motzko, C., Noll, O., Piñeiro, D. Rodríguez, Fritsch, M., Schupp, F., Steinen, M., Wolff, S., Zimmermann, I., Fedorov, Rostislav, Kazlou, D., Korzhik, M., Missevitch, O., Balanutsa, P., Chernetsky, V., Grochowski, J., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Golubev, A., Goryachev, V., Kantsyrev, A., Kirin, D. Y., Kristi, N., Ladygina, E., Hagdorn, R., Luschevskaya, E., Matveev, V. A., Panjushkin, V., Stavinskiy, A. V., Balashoff, A., Boukharov, A., Malyshev, O., Basant, K. N., Kumawat, H., Roy, B., Heinsius, F. H., Saxena, A., Yogesh, S., Bonaventura, D., Brand, P., Fritzsch, C., Grieser, S., Hargens, C., Hergemöller, A. K., Hetz, B., Hüsken, N., Held, T., Kellers, J., Khoukaz, A., Mannweiler, C., Vestrick, S., Bumrungkoh, D., Herold, C., Khosonthongkee, K., Kobdaj, C., Limphirat, A., Manasatitpong, K., Holtmann, T., Nasawad, T., Pongampai, S., Simantathammakul, T., Srisawad, P., Wongprachanukul, N., Yan, Y., Yu, C., Zhang, Xu, Zhu, W., Blinov, A. E., Keshk, I., Kononov, S., Kravchenko, E. A., Antokhin, E., Barnyakov, A. Yu., Beloborodov, K., Blinov, V. E., Kuyanov, I. A., Pivovarov, S., Pyata, E., Tikhonov, Y., Koch, Hermann-Andreas, Hunter, G., Lattery, M., Pace, H., Boca, G., Duda, D., Finger, M., Kveton, A., Pesek, M., Peskova, M., Kopf, B., Prochazka, I., Slunecka, M., Volf, M., Gallus, P., Jary, V., Korchak, O., Marcisovsky, M., Neue, G., Novy, J., Tomasek, L., Montalto, L., Kuhlmann, M., Tomasek, M., Virius, M., Vrba, V., Abramov, V., Bukreeva, S., Chernichenko, S., Derevschikov, A., Ferapontov, V., Goncharenko, Y., Levin, A., Kümmel, M., Maslova, E., Melnik, Y., Meschanin, A., Minaev, N., Mochalov, V., Moiseev, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Küßner, M., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Roy, Lucia, Yabsley, B., Belostotski, S., Fedotov, G., Li, Jing, Gavrilov, G., Izotov, A., Manaenkov, S., Miklukho, O., Zhdanov, A., Atac, A., Bäck, T., Cederwall, B., Makonyi, K., Preston, M., Linzen, L., Tegner, P. E., Wölbing, D., Gandhi, K., Rai, Pratika, Godre, S., Crede, V., Dobbs, S., Eugenio, P., Lersch, D., Calvo, D., Maldaner, S., De Remigis, P., Filippi, A., Mazza, G., Rivetti, A., Wheadon, R., Bussa, M. P., Spataro, S., Iazzi, F., Lavagno, A., Martin, A., Oppotsch, J., Akram, Muhammad Naeem, Calen, H., Andersson, W. Ikegami, Johansson, T., Kupsc, Andrzej, Marciniewski, P., Papenbrock, M., Regina, J., Rieger, J., Schönning, K., Pankonin, S., Wolke, Magnus, Pothodi Chackara, V., Chlopik, A., Kesik, G., Melnychuk, D., Tarasiuk, J., Wojciechowski, M., Wronka, S., Zwieglinski, B., Amsler, C., Pelizäus, M., Bühler, P., Marton, J., Nalti, W., Steinschaden, D., Widmann, E., Zimmermann, S., Zmeskal, J., Pflüger, S., Natali, P. P., Pitka, A., Reher, J., Reicherz, G., Schnier, C., Steinke, M., Triffterer, T., Wenzel, C., Wiedner, U., Denizli, H., Er, N., Paone, N., Keskin, U., Olgun, A. T., Yerlikaya, S., Yilmaz, A., Beck, R., Hammann, C., Hartmann, J., Ketzer, B., Müllers, J., Rossbach, M., Rinaldi, D., Salisbury, B., Schmidt, C., Thoma, U., Urban, M., Bianconi, A., Bragadireanu, M., Pantea, D., Domagala, M., Filo, G., Lisowski, E., Scalise, L., Lisowski, F., Michałek, M., Poznański, P., Płażek, J., Korcyl, K., Kozela, A., Lebiedowicz, P., Pysz, K., Schäfer, W., Szczurek, A., Erni, W., Firlej, M., Fiutowski, T., Idzik, M., Moron, J., Swientek, K., Terlecki, P., Korcyl, G., Lalik, R., Malige, A., and Moskal, Pawel

Subjects
ddc:530
Abstract

This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, vertical bar G(E)vertical bar and vertical bar G(M)vertical bar, using the (p) over barp -> mu(+)mu(-) reaction at PANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at PANDA, using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is (p) over barp -> pi(+)pi(-), due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distributions of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented.

Published
2020

7. High copper concentration reduces biofilm formation in Acidithiobacillus ferrooxidans by decreasing production of extracellular polymeric substances and its adherence to elemental sulfur

Author

Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Instituto de Salud Carlos III, Vargas-Straube, M. J., Beard, S., Norambuena, Rodrigo, Paradela, Alberto, Vera, M., Jerez, Carlos A., Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Instituto de Salud Carlos III, Vargas-Straube, M. J., Beard, S., Norambuena, Rodrigo, Paradela, Alberto, Vera, M., and Jerez, Carlos A.

Abstract

Acidithiobacillus ferrooxidans is an acidophilic bacterium able to grow in environments with high concentrations of metals. It is a chemolithoautotroph able to form biofilms on the surface of solid minerals to obtain its energy. The response of both planktonic and sessile cells of A. ferrooxidans ATCC 23270 grown in elemental sulfur and adapted to high copper concentration was analyzed by quantitative proteomics. It was found that 137 proteins varied their abundance when comparing both lifestyles. Copper effllux proteins, some subunits of the ATP synthase complex, porins, and proteins involved in cell wall modification increased their abundance in copper-adapted sessile lifestyle cells. On the other hand, planktonic copper-adapted cells showed increased levels of proteins such as: cupreredoxins involved in copper cell sequestration, some proteins related to sulfur metabolism, those involved in biosynthesis and transport of lipopolysaccharides, and in assembly of type IV pili. During copper adaptation a decreased formation of biofilms was measured as determined by epifluorescence microscopy. This was apparently due not only to a diminished number of sessile cells but also to their exopolysaccharides production. This is the first study showing that copper, a prevalent metal in biomining environments causes dispersion of A. ferrooxidans biofilms.

Published
2020

12. An Interface Between a Hospital Information System and a Computerized Medical Record

Author

Hammond, W. E., Stead, W. W., Straube, M. J., Kelly, M., and Winfree, R. G.

Subjects
Distributed Systems II
Abstract

There is a growing overlap between hospital information systems and medical information systems in both data storage and function. The development of an integrated system is the best approach to reducing redundancy without compromising function. An initial interface has been established between the hospital information system and a medical information system at Duke Univeristy as the first step toward achieving an integrated data base.

Published
1980

13. Planned Networking for Medical Information Systems

Author

Hammond, W. E., WILLIAM STEAD, and Straube, M. J.

Subjects
Networking and Communications
Abstract

Local area networks and distributed systems provide major advantages in flexibility, expansion, reliability, and improved response time. This paper presents our experiences in developing and implementing Ethernet using Digital hardware and DECnet networking software. A laboratory system implementation using two microcomputers and a superminicomputer is discussed in detail.

Published
1985

17. NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner.

Author

Nascimento M, Huot-Marchand S, Fanny M, Straube M, Le Bert M, Savigny F, Apetoh L, Van Snick J, Trovero F, Chamaillard M, Quesniaux VFJ, Ryffel B, Gosset P, Gombault A, Riteau N, Sokol H, and Couillin I

Subjects
Animals, Mice, Mice, Inbred C57BL, Cells, Cultured, Epithelial Cells cytology, Epithelial Cells pathology, Feces microbiology, Bacteria classification, Bacteria metabolism, Biodiversity, Gene Expression, Receptors, Cell Surface deficiency, Receptors, Cell Surface genetics, Receptors, Cell Surface metabolism, Pneumonia chemically induced, Pneumonia genetics, Pneumonia microbiology, Tobacco Smoke Pollution, Gastrointestinal Microbiome
Abstract

Chronic obstructive pulmonary disease (COPD) is a major health issue primarily caused by cigarette smoke (CS) and characterized by breathlessness and repeated airway inflammation. NLRP6 is a cytosolic innate receptor controlling intestinal inflammation and orchestrating the colonic host-microbial interface. However, its roles in the lungs remain largely unexplored. Using CS exposure models, our data show that airway inflammation is strongly impaired in Nlrp6-deficient mice with drastically fewer recruited neutrophils, a key cell subset in inflammation and COPD. We found that NLRP6 expression in lung epithelial cells is important to control airway and lung tissue inflammation in an inflammasome-dependent manner. Since gut-derived metabolites regulate NLRP6 inflammasome activation in intestinal epithelial cells, we investigated the link between NLRP6, CS-driven lung inflammation, and gut microbiota composition. We report that acute CS exposure alters gut microbiota in both wild-type (WT) and Nlrp6-deficient mice and that antibiotic treatment decreases CS-induced lung inflammation. In addition, gut microbiota transfer from dysbiotic Nlrp6-deficient mice to WT mice decreased airway lung inflammation in WT mice, highlighting an NLRP6-dependent gut-to-lung axis controlling pulmonary inflammation., Competing Interests: Author FT was employed by company ArtImmunne SAS. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Nascimento, Huot-Marchand, Fanny, Straube, Le Bert, Savigny, Apetoh, Van Snick, Trovero, Chamaillard, Quesniaux, Ryffel, Gosset, Gombault, Riteau, Sokol and Couillin.)

Published
2023
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18. Hydroxychloroquine sulfate: A novel treatment for lipin-1 deficiency?

Author

Renard P, Caccavelli L, Legendre A, Tuchmann-Durand C, Balakirouchenane D, Blanchet B, Narjoz C, Straube M, Hubas A, Garros A, Mention K, Bednarek N, Goudin N, Broissand C, Schlatter J, Cisternino S, Cagnard N, van Endert P, Diana J, de Calbiac H, and de Lonlay P

Subjects
Humans, Cytokines, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Phosphatidate Phosphatase genetics, Hydroxychloroquine pharmacology, Hydroxychloroquine therapeutic use, Quality of Life
Abstract

Background: Lipin-1 deficiency is a life-threatening disease that causes severe rhabdomyolysis (RM) and chronic symptoms associated with oxidative stress. In the absence of treatment, Hydroxychloroquine sulfate (HCQ) was administered to patients off label use on a compassionate basis in order to improve their physical conditions., Methods: Eleven patients with LPIN1 mutations were treated with HCQ. Clinical and biological efficacy and tolerance were assessed, including pain and quality of life, physical capacities, cardiopulmonary parameters, creatine kinase levels and plasma proinflammatory cytokines. To explore a dose-dependent effect of HCQ, primary myoblasts from 4 patients were incubated with various HCQ concentrations in growth medium (GM) or during starvation (EBSS medium) to investigate autophagy and oxidative stress., Findings: Under HCQ treatment, patient physical capacities improved. Abnormal cardiac function and peripheral muscle adaptation to exercise were normalized. However, two patients who had the highest mean blood HCQ concentrations experienced RM. We hypothesized that HCQ exerts deleterious effects at high concentrations by blocking autophagy, and beneficial effects on oxidative stress at low concentrations. We confirmed in primary myoblasts from 4 patients that high in vitro HCQ concentration (10 µM) but not low concentration (1 µM and 0.1 µM) induced autophagy blockage by modifying endolysosomal pH. Low HCQ concentration (1 µM) prevented reactive oxygen species (ROS) and oxidized DNA accumulation in myoblasts during starvation., Interpretation: HCQ improves the condition of patients with lipin-1 deficiency, but at low concentrations. In vitro, 1 µM HCQ decreases oxidative stress in myoblasts whereas higher concentrations have a deleterious effect by blocking autophagy., Competing Interests: Declaration of Competing Interest PVE and PDL have filed PCT (WO/2017/085115; EP3377095; PCT/EP2016/077843) and US patent applications (US20180325890). PVE and PDL have filed PCT (WO/2019/020732; PCT/EP2018/070256) patent applications. The remaining authors have no competing interests., (Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Published
2023
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19. Baseline of Physiological Body Temperature and Hematological Parameters in Captive Rousettus aegyptiacus and Eidolon helvum Fruit Bats.

Author

Rissmann M, Friedrichs V, Kley N, Straube M, Sadeghi B, and Balkema-Buschmann A

Abstract

The discovery of bats as reservoir hosts for a number of highly pathogenic zoonotic agents has led to an increasing interest of infectious disease research in experimental studies with bats. Therefore, we established breeding colonies of Rousettus aegyptiacus and Eidolon helvum fruit bats, which both have been identified as reservoir hosts for relevant zoonotic disease agents, such as Marburg virus and Lagos bat virus. Since 2013, individuals of both species have been recruited to the Friedrich-Loeffler-Institut (FLI) from zoological gardens in Europe, to where these species had been introduced from the wild several decades ago. The aviaries have been designed according to national recommendations published by the Federal Ministry of Agriculture. Under these conditions, both species have been reproducing for years. To better understand the physiology of these animals, and to generate baseline knowledge for infection experiments, we monitored the body core temperatures of R. aegyptiacus bats in the aviaries, and found a circadian variation between 34°C and 41.5°C. We also determined the hematological parameters of both species, and detected specific differences between both bat species. For values of clinical chemistry, no correlation to age or sex was observed. However, species-specific differences were detected since ALT, BUN and CREA were found to be significantly higher in R. aegyptiacus and GLU and TP were significantly higher in E. helvum bats. A higher hematocrit, hemoglobin and red blood cell level was observed in subadult R. aegyptiacus , with hemoglobin and red blood cells also being significantly increased compared to E. helvum . Lymphocytes were found to be the dominant white blood cells in both species and are higher in female E. helvum . Neutrophil granulocytes were significantly higher in E. helvum bats. This underlines the necessity to define baseline profiles for each bat species prior to their use in experimental challenge., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Rissmann, Friedrichs, Kley, Straube, Sadeghi and Balkema-Buschmann.)

Published
2022
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20. Human CD4+CD8α+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation.

Author

Touch S, Godefroy E, Rolhion N, Danne C, Oeuvray C, Straube M, Galbert C, Brot L, Alonso Salgueiro I, Chadi S, Ledent T, Chatel JM, Langella P, Jotereau F, Altare F, and Sokol H

Subjects
Animals, Humans, Inflammation, Mice, Colitis immunology, Faecalibacterium prausnitzii, Inflammatory Bowel Diseases immunology, T-Lymphocytes, Regulatory immunology
Abstract

Abundance of Faecalibacterium prausnitzii, a dominant bacterium of the human microbiota that exhibits antiinflammatory effects, is decreased in patients with inflammatory bowel diseases (IBD). In humans, colonic lamina propria contains IL-10-secreting, Foxp3- Tregs characterized by a double expression of CD4 and CD8α (DP8α) and a specificity for F. prausnitzii. This Treg subset is decreased in IBD. The in vivo effect of DP8α cells has not been evaluated yet to our knowledge. Here, using a humanized model of a NSG immunodeficient mouse strain that expresses the HLA D-related allele HLA-DR*0401 but not murine class II (NSG-Ab° DR4) molecules, we demonstrated a protective effect of a HLA-DR*0401-restricted DP8α Treg clone combined with F. prausnitzii administration in a colitis model. In a cohort of patients with IBD, we showed an independent association between the frequency of circulating DP8α cells and disease activity. Finally, we pointed out a positive correlation between F. prausnitzii-specific DP8α Tregs and the amount of F. prausnitzii in fecal microbiota in healthy individuals and patients with ileal Crohn's disease.

Published
2022
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21. AhR/IL-22 pathway as new target for the treatment of post-infectious irritable bowel syndrome symptoms.

Author

Meynier M, Baudu E, Rolhion N, Defaye M, Straube M, Daugey V, Modoux M, Wawrzyniak I, Delbac F, Villéger R, Méleine M, Borras Nogues E, Godfraind C, Barnich N, Ardid D, Poirier P, Sokol H, Chatel JM, Langella P, Livrelli V, Bonnet M, and Carvalho FA

Subjects
Animals, Bacteria classification, Bacteria genetics, Bacteria isolation & purification, Bacteria metabolism, Cognition, Depression genetics, Depression metabolism, Depression psychology, Fatty Acids, Volatile metabolism, Gastrointestinal Microbiome, Humans, Interleukins genetics, Intestines metabolism, Intestines microbiology, Irritable Bowel Syndrome metabolism, Irritable Bowel Syndrome microbiology, Mice, Mice, Inbred C57BL, Receptors, Aryl Hydrocarbon genetics, Interleukin-22, Depression etiology, Interleukins metabolism, Irritable Bowel Syndrome complications, Irritable Bowel Syndrome psychology, Receptors, Aryl Hydrocarbon metabolism
Abstract

Alterations in brain/gut/microbiota axis are linked to Irritable Bowel Syndrome (IBS) physiopathology. Upon gastrointestinal infection, chronic abdominal pain and anxio-depressive comorbidities may persist despite pathogen clearance leading to Post-Infectious IBS (PI-IBS). This study assesses the influence of tryptophan metabolism, and particularly the microbiota-induced AhR expression, on intestinal homeostasis disturbance following gastroenteritis resolution, and evaluates the efficacy of IL-22 cytokine vectorization on PI-IBS symptoms. The Citrobacter rodentium infection model in C57BL6/J mice was used to mimic Enterobacteria gastroenteritis. Intestinal homeostasis was evaluated as low-grade inflammation, permeability, mucosa-associated microbiota composition, and colonic sensitivity. Cognitive performances and emotional state of animals were assessed using several tests. Tryptophan metabolism was analyzed by targeted metabolomics. AhR activity was evaluated using a luciferase reporter assay method. One Lactococcus lactis strain carrying an eukaryotic expression plasmid for murine IL-22 ( L. lactis IL-22 ) was used to induce IL-22 production in mouse colonic mucosa. C. rodentium -infected mice exhibited persistent colonic hypersensitivity and cognitive impairments and anxiety-like behaviors after pathogen clearance. These post-infectious disorders were associated with low-grade inflammation, increased intestinal permeability, decrease of Lactobacillaceae abundance associated with the colonic layer, and increase of short-chain fatty acids (SCFAs). During post-infection period, the indole pathway and AhR activity were decreased due to a reduction of tryptophol production. Treatment with L. lactis IL-22 restored gut permeability and normalized colonic sensitivity, restored cognitive performances and decreased anxiety-like behaviors. Data from the video-tracking system suggested an upgrade of welfare for mice receiving the L.lactis IL-22 strain. Our findings revealed that AhR/IL-22 signaling pathway is altered in a preclinical PI-IBS model. IL-22 delivering alleviate PI-IBS symptoms as colonic hypersensitivity, cognitive impairments, and anxiety-like behaviors by acting on intestinal mucosa integrity. Thus, therapeutic strategies targeting this pathway could be developed to treat IBS patients suffering from chronic abdominal pain and associated well-being disorders.

Published
2022
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22. Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation.

Author

Michaudel C, Bataille F, Maillet I, Fauconnier L, Colas C, Sokol H, Straube M, Couturier-Maillard A, Dumoutier L, van Snick J, Quesniaux VF, Togbe D, and Ryffel B

Subjects
Animals, Antibodies, Neutralizing immunology, Antibodies, Neutralizing therapeutic use, Basic Helix-Loop-Helix Transcription Factors genetics, CD4-Positive T-Lymphocytes immunology, Interleukin-17 immunology, Interleukin-17 metabolism, Interleukins genetics, Interleukins immunology, Lipoxins metabolism, Lung Injury drug therapy, Mice, Mice, Inbred C57BL, Mice, Knockout, Pneumonia drug therapy, Receptors, Aryl Hydrocarbon genetics, Receptors, Interleukin-17 genetics, Respiratory Hypersensitivity drug therapy, Tryptophan metabolism, Interleukin-22, Basic Helix-Loop-Helix Transcription Factors metabolism, Interleukins metabolism, Lung Injury chemically induced, Lung Injury metabolism, Ozone adverse effects, Pneumonia chemically induced, Pneumonia metabolism, Receptors, Aryl Hydrocarbon metabolism, Respiratory Hypersensitivity chemically induced, Respiratory Hypersensitivity metabolism
Abstract

Airborne ozone exposure causes severe lung injury and inflammation. The aryl hydrocarbon Receptor (AhR) (1), activated in pollutant-induced inflammation, is critical for cytokine production, especially IL-22 and IL-17A. The role of AhR in ozone-induced lung inflammation is unknown. We report here that chronic ozone exposure activates AhR with increased tryptophan and lipoxin A4 production in mice. AhR -/- mice show increased lung inflammation, airway hyperresponsiveness, and tissue remodeling with an increased recruitment of IL-17A and IL-22-expressing cells in comparison to control mice. IL-17A- and IL-22-neutralizing antibodies attenuate lung inflammation in AhR -/- and control mice. Enhanced lung inflammation and recruitment of ILC3, ILC2, and T cells were observed after T cell-specific AhR depletion using the AhR CD4cre -deficient mice. Together, the data demonstrate that ozone exposure activates AhR, which controls lung inflammation, airway hyperresponsiveness, and tissue remodeling via the reduction of IL-22 expression., (Copyright © 2020 Michaudel, Bataille, Maillet, Fauconnier, Colas, Sokol, Straube, Couturier-Maillard, Dumoutier, van Snick, Quesniaux, Togbe and Ryffel.)

Published
2020
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23. Influenza A Virus Pre-Infection Exacerbates Pseudomonas aeruginosa -Mediated Lung Damage Through Increased MMP-9 Expression, Decreased Elafin Production and Tissue Resilience.

Author

Villeret B, Solhonne B, Straube M, Lemaire F, Cazes A, Garcia-Verdugo I, and Sallenave JM

Subjects
Animals, Cell Line, Coinfection chemically induced, Coinfection metabolism, Cystic Fibrosis immunology, Cytokines metabolism, Disease Susceptibility metabolism, Epithelial Cells metabolism, Humans, Inflammation chemically induced, Inflammation immunology, Lung immunology, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Animal, Pneumonia metabolism, Staphylococcal Infections immunology, Coinfection immunology, Elafin metabolism, Influenza A virus immunology, Matrix Metalloproteinase 9 metabolism, Pseudomonas aeruginosa immunology
Abstract

Individuals with impaired immune responses, such as ventilated and cystic fibrosis patients are often infected with Pseudomonas aeruginosa ( P.a ) bacteria, and a co-infection with the Influenza virus (IAV) is often present. It has been known for many years that infection with IAV predisposes the host to secondary bacterial infections (such as Streptococcus pneumoniae or Staphylococcus aureus ), and there is an abundance of mechanistic studies, including those studying the role of desensitization of TLR signaling, type I IFN- mediated impairment of neutrophil chemokines and antimicrobial production, attenuation of IL1β production etc., showing this. However, little is known about the mechanistic events underlying the potential deleterious synergy between Influenza and P.a co-infections. We demonstrate here in vitro in epithelial cells and in vivo in three independent models (two involving mice given IAV +/- P.a , and one involving mice given IAV +/- IL-1β) that IAV promotes secondary P.a -mediated lung disease or augmented IL-1β-mediated inflammation. We show that IAV- P.a -mediated deleterious responses includes increased matrix metalloprotease (MMP) activity, and MMP-9 in particular, and that the use of the MMP inhibitor improves lung resilience. Furthermore, we show that IAV post-transcriptionally inhibits the antimicrobial/anti-protease molecule elafin/trappin-2, which we have shown previously to be anti-inflammatory and to protect the host against maladaptive neutrophilic inflammation in P.a infections. Our work highlights the capacity of IAV to promote further P.a -mediated lung damage, not necessarily through its interference with host resistance to the bacterium, but by down-regulating tissue resilience to lung inflammation instead. Our study therefore suggests that restoring tissue resilience in clinical settings where IAV/ P.a co-exists could prove a fruitful strategy., (Copyright © 2020 Villeret, Solhonne, Straube, Lemaire, Cazes, Garcia-Verdugo and Sallenave.)

Published
2020
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24. Variability and repeatability of noctule bat migration in Central Europe: evidence for partial and differential migration.

Author

Lehnert LS, Kramer-Schadt S, Teige T, Hoffmeister U, Popa-Lisseanu A, Bontadina F, Ciechanowski M, Dechmann DKN, Kravchenko K, Presetnik P, Starrach M, Straube M, Zoephel U, and Voigt CC

Subjects
Animals, Female, Germany, Male, Poland, Sex Factors, Slovenia, Switzerland, Animal Migration, Chiroptera physiology
Abstract

Each year, large numbers of bats move across Europe between their summer and winter areas, yet even though many of them are endangered and legally protected, we are unaware about many aspects of their migratory behaviour. Here, taking Nyctalus noctula as a model species, we used stable hydrogen isotopic values in fur ( δ 2 H f ) as an endogenous marker to shed light on the migratory behaviour of more than 1000 bats from hibernacula across Central Europe. Specifically, we asked the following questions: how flexible is migration in temperate zone bats? Which general migration pattern do noctule bats follow? How repeatable and thus predictable is the migratory behaviour of individuals? Do morphological correlates of migration occur in bats? Our study confirmed that noctule bats engage in partial and female-biased migration across Europe, suggesting the strongest migration pressures for northern populations. Further, we revealed a combination of partial and differential migration patterns with highly variable migration distances which lead to a pronounced mixing of different source populations in hibernacula where mating occurs. Most individuals were consistent in their migration strategy over time, i.e. 86% could be repeatedly assigned to either long-distance or regional origin across years. This is consistent with our finding that the between-individual component explained 84% of the variation in δ 2 H f values, suggesting specialized individual migratory behaviours and a strong natal philopatry. We discovered a positive correlation between forearm length and migration distance and support for sex-specific effects of migration on body condition. Our study elucidated migration patterns over large geographical scales, demonstrating that considerable numbers of migratory bats originating from distant populations depend on hibernacula across Central Europe, calling for international conservation management.

Published
2018
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25. Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome.

Author

Natividad JM, Agus A, Planchais J, Lamas B, Jarry AC, Martin R, Michel ML, Chong-Nguyen C, Roussel R, Straube M, Jegou S, McQuitty C, Le Gall M, da Costa G, Lecornet E, Michaudel C, Modoux M, Glodt J, Bridonneau C, Sovran B, Dupraz L, Bado A, Richard ML, Langella P, Hansel B, Launay JM, Xavier RJ, Duboc H, and Sokol H

Subjects
Animals, Limosilactobacillus reuteri metabolism, Ligands, Male, Metabolic Syndrome drug therapy, Metabolic Syndrome therapy, Mice, Mice, Inbred C57BL, Probiotics therapeutic use, Receptors, Aryl Hydrocarbon agonists, Gastrointestinal Microbiome, Metabolic Syndrome metabolism, Metabolic Syndrome microbiology, Receptors, Aryl Hydrocarbon metabolism, Tryptophan metabolism
Abstract

The extent to which microbiota alterations define or influence the outcome of metabolic diseases is still unclear, but the byproducts of microbiota metabolism are known to have an important role in mediating the host-microbiota interaction. Here, we identify that in both pre-clinical and clinical settings, metabolic syndrome is associated with the reduced capacity of the microbiota to metabolize tryptophan into derivatives that are able to activate the aryl hydrocarbon receptor. This alteration is not merely an effect of the disease as supplementation with AhR agonist or a Lactobacillus strain, with a high AhR ligand-production capacity, leads to improvement of both dietary- and genetic-induced metabolic impairments, particularly glucose dysmetabolism and liver steatosis, through improvement of intestinal barrier function and secretion of the incretin hormone GLP-1. These results highlight the role of gut microbiota-derived metabolites as a biomarker and as a basis for novel preventative or therapeutic interventions for metabolic disorders., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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26. Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes.

Author

Miani M, Le Naour J, Waeckel-Enée E, Verma SC, Straube M, Emond P, Ryffel B, van Endert P, Sokol H, and Diana J

Subjects
Animals, B-Lymphocytes, Regulatory metabolism, Female, Humans, Immunity, Innate, Interleukins metabolism, Islets of Langerhans metabolism, Kaplan-Meier Estimate, Macrophages metabolism, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred NOD, Statistics, Nonparametric, T-Lymphocytes, Regulatory metabolism, Toll-Like Receptor 2 metabolism, Interleukin-22, Diabetes Mellitus, Type 1 immunology, Diabetes Mellitus, Type 1 prevention & control, Gastrointestinal Microbiome immunology, Insulin-Secreting Cells metabolism, Lymphocytes metabolism, Pancreatic Polypeptide-Secreting Cells metabolism, beta-Defensins metabolism
Abstract

The gut microbiota is essential for the normal function of the gut immune system, and microbiota alterations are associated with autoimmune disorders. However, how the gut microbiota prevents autoimmunity in distant organs remains poorly defined. Here we reveal that gut microbiota conditioned innate lymphoid cells (ILCs) induce the expression of mouse β-defensin 14 (mBD14) by pancreatic endocrine cells, preventing autoimmune diabetes in the non-obese diabetic (NOD) mice. MBD14 stimulates, via Toll-like receptor 2, interleukin-4 (IL-4)-secreting B cells that induce regulatory macrophages, which in turn induce protective regulatory T cells. The gut microbiota-derived molecules, aryl hydrocarbon receptor (AHR) ligands and butyrate, promote IL-22 secretion by pancreatic ILCs, which induce expression of mBD14 by endocrine cells. Dysbiotic microbiota and low-affinity AHR allele explain the defective pancreatic expression of mBD14 observed in NOD mice. Our study reveals a yet unidentified crosstalk between ILCs and endocrine cells in the pancreas that is essential for the prevention of autoimmune diabetes development., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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27. Enterobacteriaceae are essential for the modulation of colitis severity by fungi.

Author

Sovran B, Planchais J, Jegou S, Straube M, Lamas B, Natividad JM, Agus A, Dupraz L, Glodt J, Da Costa G, Michel ML, Langella P, Richard ML, and Sokol H

Subjects
Animals, Antibiosis, Antibodies administration & dosage, Candida albicans genetics, Candida albicans isolation & purification, Colitis drug therapy, Disease Models, Animal, Enterobacteriaceae classification, Enterobacteriaceae genetics, Enterobacteriaceae isolation & purification, Female, Gastrointestinal Microbiome, Humans, Mice, Mice, Inbred C57BL, Saccharomyces boulardii genetics, Saccharomyces boulardii isolation & purification, Candida albicans physiology, Colitis microbiology, Enterobacteriaceae physiology, Saccharomyces boulardii physiology
Abstract

Background: Host-microbe balance maintains intestinal homeostasis and strongly influences inflammatory conditions such as inflammatory bowel diseases (IBD). Here we focused on bacteria-fungi interactions and their implications on intestinal inflammation, a poorly understood area., Methods: Dextran sodium sulfate (DSS)-induced colitis was assessed in mice treated with vancomycin (targeting gram-positive bacteria) or colistin (targeting Enterobacteriaceae) and supplemented with either Saccharomyces boulardii CNCM I-745 or Candida albicans. Inflammation severity as well as bacterial and fungal microbiota compositions was monitored., Results: While S. boulardii improved DSS-induced colitis and C. albicans worsened it in untreated settings, antibiotic treatment strongly modified DSS susceptibility and effects of fungi on colitis. Vancomycin-treated mice were fully protected from colitis, while colistin-treated mice retained colitis phenotype but were not affected anymore by administration of fungi. Antibacterial treatments not only influenced bacterial populations but also had indirect effects on fungal microbiota. Correlations between bacterial and fungal relative abundance were dramatically decreased in colistin-treated mice compared to vancomycin-treated and control mice, suggesting that colistin-sensitive bacteria are involved in interactions with fungi. Restoration of the Enterobacteriaceae population by administrating colistin-resistant Escherichia coli reestablished both beneficial effects of S. boulardii and pathogenic effects of C. albicans on colitis severity. This effect was at least partly mediated by an improved gut colonization by fungi., Conclusions: Fungal colonization of the gut is affected by the Enterobacteriaceae population, indirectly modifying effects of mycobiome on the host. This finding provides new insights into the role of inter-kingdom functional interactions in intestinal physiopathology and potentially in IBD.

Published
2018
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28. Mature teratoma of the temporal bone in 3.5-month-old baby girl.

Author

Alqurashi A, Bakry E, Straube M, Rickert CH, and Mir-Salim P

Abstract

Mature teratoma is a benign germ cell tumor rarely located in the temporal bone. We are reporting a case of a mature teratoma of the temporal bone in a healthy borne 3.5-month-old baby girl with a 2-day suggestive history of otitis media and polypoidal mass expulsing from the external auditory canal of the left ear. A definitive diagnosis is made after complete excision and histological examination of the tissue. Total surgical excision of the tumor is the treatment of choice.

Published
2015
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29. Cowpox virus outbreak in banded mongooses (Mungos mungo) and jaguarundis (Herpailurus yagouaroundi) with a time-delayed infection to humans.

Author

Kurth A, Straube M, Kuczka A, Dunsche AJ, Meyer H, and Nitsche A

Subjects
Animals, Cowpox transmission, Disease Outbreaks, Felidae, Female, Herpestidae, Humans, Male, Microscopy, Electron, Phylogeny, Polymerase Chain Reaction, Rats, Risk, Time Factors, Zoonoses epidemiology, Zoonoses transmission, Cowpox epidemiology, Cowpox virus metabolism
Abstract

Background: Often described as an extremely rare zoonosis, cowpox virus (CPXV) infections are on the increase in Germany. CPXV is rodent-borne with a broad host range and contains the largest and most complete genome of all poxviruses, including parts with high homology to variola virus (smallpox). So far, most CPXV cases have occurred individually in unvaccinated animals and humans and were caused by genetically distinguishable virus strains., Methodology/principal Findings: Generalized CPXV infections in banded mongooses (Mungos mungo) and jaguarundis (Herpailurus yagouaroundi) at a Zoological Garden were observed with a prevalence of the affected animal group of 100% and a mortality of 30%. A subsequent serological investigation of other exotic animal species provided evidence of subclinical cases before the onset of the outbreak. Moreover, a time-delayed human cowpox virus infection caused by the identical virus strain occurred in a different geographical area indicating that handling/feeding food rats might be the common source of infection., Conclusions/significance: Reports on the increased zoonotic transmission of orthopoxviruses have renewed interest in understanding interactions between these viruses and their hosts. The list of animals known to be susceptible to CPXV is still growing. Thus, the likely existence of unknown CPXV hosts and their distribution may present a risk for other exotic animals but also for the general public, as was shown in this outbreak. Animal breeders and suppliers of food rats represent potential multipliers and distributors of CPXV, in the context of increasingly pan-European trading. Taking the cessation of vaccination against smallpox into account, this situation contributes to the increased incidence of CPXV infections in man, particularly in younger age groups, with more complicated courses of clinical infections.

Published
2009
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