Search

Your search keyword '"Strasser, Ruth H."' showing total 282 results
Start Over Author "Strasser, Ruth H." Search Limiters Full Text
282 results on '"Strasser, Ruth H."'

1. Comparison of external and intravascular cooling to induce hypothermia in patients after CPR

Author

Strasser, Ruth H., Wunderlich, Carsten, Gildemeister, Ramona, Diewok, Claudia, Ziegs, Enrico, Simonis, Gregor, and Flemming, Kerstin

Subjects
Medicine
Abstract

Objective: Hypothermia has been shown to reduce neurologic deficits in patients after cardiopulmonary resuscitation (CPR). It was not clear if intravascular cooling is superior to standard external cooling in inducing hypothermia. Goal of this study was to compare intravascular cooling with an automated cooling device with external cooling in everyday practice on a cardiac-care ICU (intensive care unit). Methods: Patients after successful CPR for unwitnessed cardiac arrest were subjected to cooling with an automated cooling system (CoolGard, Alsius) after initial hemodynamic stabilization. Goal was to achieve a core temperature of 33°C. Monitored were the time intervals from admission to begin of cooling and from begin of cooling to target temperature. Data were compared retrospectively with those from patients subjected to external cooling. Results: 31 consecutive patients treated with intravascular cooling were analyzed. Cooling was initiated at a mean time of 58 min after admission, and the target temperature of 33°C was achieved after a mean of 3.48 hours after the begin of cooling. In contrast, 49 patients treated with external cooling achieved a minimum temperature of 34.8°C only 9.2 hours after admission. Conclusion: In everyday practice, intravascular cooling using an automated cooling system is superior for a rapid induction of hypothermia after cardiac arrest.

Published
2006

2. Evaluation of systemic inflammation in response to remote ischemic preconditioning in patients undergoing transcatheter aortic valve replacement (TAVR)

Author

Zhang, Kun, Troeger, Willi, Kuhn, Matthias, Wiedemann, Stephan, Ibrahim, Karim, Pfluecke, Christian, Sveric, Krunoslav M., Winzer, Robert, Fedders, Dieter, Ruf, Tobias F., Strasser, Ruth H., Linke, Axel, Quick, Silvio, Heidrich, Felix M., Zhang, Kun, Troeger, Willi, Kuhn, Matthias, Wiedemann, Stephan, Ibrahim, Karim, Pfluecke, Christian, Sveric, Krunoslav M., Winzer, Robert, Fedders, Dieter, Ruf, Tobias F., Strasser, Ruth H., Linke, Axel, Quick, Silvio, and Heidrich, Felix M.

Abstract

Background: Systemic inflammation can occur after transcatheter aortic valve replacement (TAVR) and correlates with adverse outcome. The impact of remote ischemic preconditioning (RIPC) on TAVR associated systemic inflammation is unknown and was focus of this study. Methods: We performed a prospective controlled trial at a single center and included 66 patients treated with remote ischemic preconditioning (RIPC) prior to TAVR, who were matched to a control group by propensity score. RIPC was applied to the upper extremity using a conventional tourniquet. Definition of systemic inflammation was based on leucocyte count, C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6), assessed in the first 5 days following the TAVR procedure. Mortality was determined within 6 months after TAVR. RIPC group and matched control group showed comparable baseline characteristics. Results: Systemic inflammation occurred in 66% of all patients after TAVR. Overall, survival after 6 months was significantly reduced in patients with systemic inflammation. RIPC, in comparison to control, did not significantly alter the plasma levels of leucocyte count, CRP, PCT or IL-6 within the first 5 days after TAVR. Furthermore, inflammation associated survival after 6 months was not improved by RIPC. Of all peri-interventional variables assessed, only the amount of the applied contrast agent was connected to the occurrence of systemic inflammation. Conclusions: Systemic inflammation frequently occurs after TAVR and leads to increased mortality after 6 months. RIPC neither reduces the incidence of systemic inflammation nor improves inflammation associated patient survival within 6 months.

Published
2024

6. Evaluation of systemic inflammation in response to remote ischemic preconditioning in patients undergoing transcatheter aortic valve replacement (TAVR)

Author

Zhang, Kun, primary, Troeger, Willi, primary, Kuhn, Matthias, primary, Wiedemann, Stephan, primary, Ibrahim, Karim, primary, Pfluecke, Christian, primary, Sveric, Krunoslav M., primary, Winzer, Robert, primary, Fedders, Dieter, primary, Ruf, Tobias F., primary, Strasser, Ruth H., primary, Linke, Axel, primary, Quick, Silvio, primary, and Heidrich, Felix M., primary

Published
2022
Full Text
View/download PDF

7. Spatio-temporal regulation of calpain activity after experimental myocardial infarction in vivo

Author

Zhang, Kun, primary, Cremers, Melissa M., additional, Wiedemann, Stephan, additional, Poitz, David M., additional, Pfluecke, Christian, additional, Heinzel, Frank R., additional, Pieske, Burkert, additional, Adams, Volker, additional, Schauer, Antje, additional, Winzer, Robert, additional, Strasser, Ruth H., additional, Linke, Axel, additional, Quick, Silvio, additional, and Heidrich, Felix M., additional

Published
2021
Full Text
View/download PDF

16. Long term survival after early unloading with Impella CP® in acute myocardial infarction complicated by cardiogenic shock

Author

Löhn, Tobias, O’Neill, William W., Lange, Björn, Pflücke, Christian, Schweigler, Tina, Mierke, Johannes, Wäßnig, Nadine, Mahlmann, Adrian, Youssef, Akram, Speiser, Uwe, Strasser, Ruth H., and Ibrahim, Karim

Subjects
surgical procedures, operative, Kardiogener Schock, akutes Koronarsyndrom, STEMI, NSTEMI, perkutanes linksventrikuläres Hilfsgerät, cardiovascular diseases, ddc:610, Cardiogenic shock, acute coronary syndrome, STEMI, NSTEMI, percutaneous left ventricular assist device
Abstract

Background: The use of percutaneous left ventricular assist devices in patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) is evolving. The aim of the study was to assess the long-term outcome of patients with AMICS depending on early initiation of Impella CP® support prior to a percutaneous coronary intervention (PCI). Methods: We retrospectively reviewed all patients who underwent PCI and Impella CP® support between 2014 and 2016 for AMICS at our institution. We compared survival to discharge between those with support initiation before (pre-PCI) and after (post-PCI) PCI. Results: A total of 73 consecutive patients (69±12 years old, 27.4% female) were supported with Impella CP® and underwent PCI for AMICS (34 pre-PCI vs. 39 post-PCI). All patients were admitted with cardiogenic shock, and 58.9% sustained cardiac arrest. Survival at discharge was 35.6%. Compared with the post-PCI group, patients in the pre-PCI group had more lesions treated (p=0.03), a higher device weaning rate (p=0.005) and higher survival to discharge as well as to 30 and 90 days after device implantation, respectively (50.0% vs. 23.1%, 48.5% vs. 23.1%, 46.9 vs. 20.5%, p < 0.05). Kaplan–Meier analysis showed a higher survival at one year (31.3% vs. 17.6%, log-rank p-value=0.03) in the pre-PCI group. Impella support initiation before PCI was an independent predictor of survival up to 180 days after device implantation. Conclusions: In this small, single-centre, non-randomized study Impella CP® initiation prior to PCI was associated with higher survival rates at discharge and up to one year in AMICS patients presenting with high risk for in-hospital mortality.

Published
2020

19. Evaluation of systemic inflammation in response to remote ischemic preconditioning in patients undergoing transcatheter aortic valve replacement (TAVR).

Author

Kun Zhang, Troeger, Willi, Kuhn, Matthias, Wiedemann, Stephan, Ibrahim, Karim, Pfluecke, Christian, Sveric, Krunoslav M., Winzer, Robert, Fedders, Dieter, Ruf, Tobias F., Strasser, Ruth H., Linke, Axel, Quick, Silvio, Heidrich, Felix M., and Zhang, Kun

Subjects
INFLAMMATION prevention, THERAPEUTICS, INFLAMMATION, AORTIC stenosis, TREATMENT effectiveness, PROSTHETIC heart valves, LONGITUDINAL method
Abstract

Background: Systemic inflammation can occur after transcatheter aortic valve replacement (TAVR) and correlates with adverse outcome. The impact of remote ischemic preconditioning (RIPC) on TAVR associated systemic inflammation is unknown and was focus of this study.Methods: We performed a prospective controlled trial at a single center and included 66 patients treated with remote ischemic preconditioning (RIPC) prior to TAVR, who were matched to a control group by propensity score. RIPC was applied to the upper extremity using a conventional tourniquet. Definition of systemic inflammation was based on leucocyte count, C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6), assessed in the first 5 days following the TAVR procedure. Mortality was determined within 6 months after TAVR. RIPC group and matched control group showed comparable baseline characteristics.Results: Systemic inflammation occurred in 66% of all patients after TAVR. Overall, survival after 6 months was significantly reduced in patients with systemic inflammation. RIPC, in comparison to control, did not significantly alter the plasma levels of leucocyte count, CRP, PCT or IL-6 within the first 5 days after TAVR. Furthermore, inflammation associated survival after 6 months was not improved by RIPC. Of all peri-interventional variables assessed, only the amount of the applied contrast agent was connected to the occurrence of systemic inflammation.Conclusions: Systemic inflammation frequently occurs after TAVR and leads to increased mortality after 6 months. RIPC neither reduces the incidence of systemic inflammation nor improves inflammation associated patient survival within 6 months. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

21. Remote Ischemic Preconditioning Neither Improves Survival nor Reduces Myocardial or Kidney Injury in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI)

Author

Flechsig, Mandy, primary, Ruf, Tobias F., additional, Troeger, Willi, additional, Wiedemann, Stephan, additional, Quick, Silvio, additional, Ibrahim, Karim, additional, Pfluecke, Christian, additional, Youssef, Akram, additional, Sveric, Krunoslav M., additional, Winzer, Robert, additional, Heinzel, Frank R., additional, Linke, Axel, additional, Strasser, Ruth H., additional, Zhang, Kun, additional, and Heidrich, Felix M., additional

Published
2020
Full Text
View/download PDF

26. Cardiac Manifestation of Wilson’s Disease

Author

Quick, Silvio, primary, Weidauer, Marie, additional, Heidrich, Felix M., additional, Sveric, Krunoslav, additional, Reichmann, Heinz, additional, Ibrahim, Karim, additional, Strasser, Ruth H., additional, Linke, Axel, additional, Speiser, Uwe, additional, and Reuner, Ulrike, additional

Published
2018
Full Text
View/download PDF

29. Abstract 676: Hypoxia Upregulates NADPH Oxidase 4-Mediated Hydrogen Peroxide Release by a HIF-Independent Mechanism in Human Endothelial Cells

Author

Brunssen, Coy, primary, Arsov, Alexander, additional, Poitz, David M, additional, Eickholt, Claudia, additional, Hofmann, Anja, additional, Langbein, Heike, additional, Brux, Melanie, additional, Engelmann, Felix, additional, Goettsch, Claudia, additional, Goettsch, Winfried, additional, Augstein, Antje, additional, Bornstein, Stefan R, additional, Strasser, Ruth H, additional, Breier, Georg, additional, and Morawietz, Henning, additional

Published
2018
Full Text
View/download PDF

31. The role of levosimendan in acute heart failure complicating acute coronary syndrome: A review and expert consensus opinion

Author

Nieminen, Markku Sakari, Buerke, Michael, Cohen-Solal, Alain, Costa, Susana, Edes, Istvan, Erlikh, Alexey, Franco, Fatima, Gibson, Charles, Gorjuph, Vojka, Guarracino, Fabio, Gustafsson, Finn, Harjola, Veli-Pekka, Husebye, Trygve, Karason, Kristjan, Katsytadze, Igor, Kaul, Sundeep, Kivikko, Matti, Marenzi, Giancarlo, Masip, Josep, Matskeplishvili, Simon, Mebazaa, Alexandre, Moller, Jacob E., Nessler, Jadwiga, Nessler, Bohdan, Ntalianis, Argyrios, Oliva, Fabrizio, Pichler-Cetin, Emel, Poder, Pentti, Recio-Mayoral, Alejandro, Rex, Steffen, Rokyta, Richard, Strasser, Ruth H., Zima, Endre, Pollesello, Piero, Clinicum, Department of Medicine, and Department of Diagnostics and Therapeutics

Subjects
3121 General medicine, internal medicine and other clinical medicine, education, 3126 Surgery, anesthesiology, intensive care, radiology
Published
2016

35. Reduction of atrial fibrillation burden by pulmonary vein isolation leads to a decrease of CD11b expression on inflammatory cells

Author

Tarnowski, Daniel, primary, Plichta, Lina, additional, Forkmann, Mathias, additional, Quick, Silvio, additional, Ulbrich, Stefan, additional, Heidrich, Felix Matthias, additional, Wiedemann, Stephan, additional, Christoph, Marian, additional, Poitz, David Maximilian, additional, Wunderlich, Carsten, additional, Ibrahim, Karim, additional, Strasser, Ruth H, additional, and Pfluecke, Christian, additional

Published
2017
Full Text
View/download PDF

37. Effects of the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone on Peripheral Vessel Function and Clinical Parameters in Nondiabetic Patients: A Double-Center, Randomized Controlled Pilot Trial

Author

Christoph, Marian, Herold, Jörg, Berg-Holldack, Anna, Rauwolf, Thomas, Ziemssen, Tjalf, Schmeisser, Alexander, Weinert, Sönke, Ebner, Bernd, Ibrahim, Karim, Strasser, Ruth H., and Braun-Dullaeus, Rüdiger C.

Subjects
Cardiovascular disease, Peroxisome proliferator-activated receptor-γ agonist, Pioglitazone, Pulse wave analysis, Intima-media thickness, Retinal vessel function, Herz-Kreislauf-Erkrankungen, Peroxisom-Proliferator-aktivierter Rezeptorγ-Agonist, Pioglitazon, Pulswellenanalyse, Intima-Media-Dicke, retinale Gefässfunktion, ddc:610
Abstract

Objective: Despite the advanced therapy with statins, antithrombotics, and antihypertensive agents, the medical treatment of atherosclerotic disease is less than optimal. Therefore, additional therapeutic antiatherosclerotic options are desirable. This pilot study was performed to assess the potential antiatherogenic effect of the peroxisome proliferator-activated receptor-γ agonist pioglitazone in nondiabetic patients. Methods: A total of 54 nondiabetic patients were observed in a prospective, double-blind, placebo-controlled study. Patients were randomized to pioglitazone or placebo. The following efficacy parameters were determined by serial analyses: artery pulse wave analysis and carotid-femoral pulse wave velocity (PWV), static and dynamic retinal vessel function, and the common carotid intima-media thickness (IMT). The main secondary endpoint was the change in different biochemical markers. Results: After 9 months, no relevant differences could be determined in the two treatment groups in PWV (pioglitazone 14.3 ± 4.4 m/s vs. placebo 14.2 ± 4.2 m/s), retinal arterial diameter (pioglitazone 112.1 ± 23.3 μm vs. placebo 117.9 ± 21.5 μm) or IMT (pioglitazone 0.85 ± 0.30 mm vs. placebo 0.79 ± 0.15 mm). Additionally, there were no differences in the change in biochemical markers like cholesteryl ester transfer protein, lowdensity lipoprotein cholesterol, high-sensitivity C-reactive protein or white blood cell count. Conclusions : Treatment with a peroxisome proliferator-activated receptor-γ agonist in nondiabetic patients did not improve the function of large and small peripheral vessels (PPP Trial, clinicaltrialsregister. eu: 2006-000186-11).

Published
2015

38. The role of levosimendan in acute heart failure complicating acute coronary syndrome: A review and expert consensus opinion

Author

University of Helsinki, Clinicum, Nieminen, Markku Sakari, Buerke, Michael, Cohen-Solal, Alain, Costa, Susana, Edes, Istvan, Erlikh, Alexey, Franco, Fatima, Gibson, Charles, Gorjuph, Vojka, Guarracino, Fabio, Gustafsson, Finn, Harjola, Veli-Pekka, Husebye, Trygve, Karason, Kristjan, Katsytadze, Igor, Kaul, Sundeep, Kivikko, Matti, Marenzi, Giancarlo, Masip, Josep, Matskeplishvili, Simon, Mebazaa, Alexandre, Moller, Jacob E., Nessler, Jadwiga, Nessler, Bohdan, Ntalianis, Argyrios, Oliva, Fabrizio, Pichler-Cetin, Emel, Poder, Pentti, Recio-Mayoral, Alejandro, Rex, Steffen, Rokyta, Richard, Strasser, Ruth H., Zima, Endre, Pollesello, Piero, University of Helsinki, Clinicum, Nieminen, Markku Sakari, Buerke, Michael, Cohen-Solal, Alain, Costa, Susana, Edes, Istvan, Erlikh, Alexey, Franco, Fatima, Gibson, Charles, Gorjuph, Vojka, Guarracino, Fabio, Gustafsson, Finn, Harjola, Veli-Pekka, Husebye, Trygve, Karason, Kristjan, Katsytadze, Igor, Kaul, Sundeep, Kivikko, Matti, Marenzi, Giancarlo, Masip, Josep, Matskeplishvili, Simon, Mebazaa, Alexandre, Moller, Jacob E., Nessler, Jadwiga, Nessler, Bohdan, Ntalianis, Argyrios, Oliva, Fabrizio, Pichler-Cetin, Emel, Poder, Pentti, Recio-Mayoral, Alejandro, Rex, Steffen, Rokyta, Richard, Strasser, Ruth H., Zima, Endre, and Pollesello, Piero

Published
2016

40. Der interzelluläre Transport Lipid-geladener Lysosomen aus Makrophagen in glatte Gefäßmuskelzellen führt zur phänotypischen Veränderung der Gefäßmuskelzellen in einen schaumzellartigen Phänotyp

Author

van Pée, Karl-Heinz, Strasser, Ruth H., Technische Universität Dresden, Weinert, Sönke, van Pée, Karl-Heinz, Strasser, Ruth H., Technische Universität Dresden, and Weinert, Sönke

Abstract

AIMS: Macrophages (MPs) and vascular smooth muscle cells (VSMCs) closely interact within the growing atherosclerotic plaque. An in vitro co-culture model was established to study how MPs modulate VSMC behaviour. METHODS AND RESULTS: MPs were exposed to fluorescence-labelled-acetylated LDL (FL-acLDL) prior to co-culture with VSMCs. Fluorescence microscopy visualized first transport of FL-acLDL within 6 h after co-culture implementation. When MPs had been fed with FL-acLDL in complex with fluorescence-labelled cholesterol (FL-Chol), these complexes were also transferred during co-culture and resulted in cholesterol positive lipid droplet formation in VSMCs. When infected with a virus coding for a fusion protein of Rab5a and fluorescent protein reporter (FP) to mark early endosomes, no co-localization between Rab5a-FP and the transported FL-acLDL within VSMCs was detected implying a mechanism independent of phagocytosis. Next, expression of lysosome-associated membrane glycoprotein 1 (LAMP1)-FP, marking all lysosomes in VSMCs, revealed that the FL-acLDL was located in non-acidic lysosomes. MPs infected with virus encoding for LAMP1-FP prior to co-culture demonstrated that intact fluorescence-marked lysosomes were transported into the VSMC, instead. Xenogenic cell composition (rat VSMC, human MP) and subsequent quantitative RT-PCR with rat-specific primers rendered induction of genes typical for MPs and down-regulation of the cholesterol sensitive HMG-CoA reductase. CONCLUSION: Our results demonstrate that acLDL/cholesterol-loaded lysosomes are transported from MPs into VSMCs in vitro. Lysosomal transfer results in a phenotypic alteration of the VSMC towards a foam cell-like cell. This way VSMCs may lose their plaque stabilizing properties and rather contribute to plaque destabilization and rupture.

Published
2015

41. Chronic diarrhea as the initial clinical manifestation of light-chain amyloidosis with cardiac involvement despite negative duodenal and rectal biopsies

Author

Pfluecke, Christian, Ulbrich, Stefan, Ibrahim, Karim, Geiger, Kathrin D, Strasser, Ruth H, and Wunderlich, Carsten

Subjects
Clinical Cardiology: Case Report
Abstract

Early and accurate diagnosis and a prompt initiation of treatment are critical for the prognosis of light-chain amyloidosis. The present article describes a case involving a 62-year-old patient who experienced unexplained, chronic diarrhea with negative duodenal and rectal biopsies. Serum immunofixation, a free light-chain assay, electrocardiography and echocardiography were performed after the patient developed syncope. The results of these diagnostic investigations showed characteristic signs of systemic amyloidosis. Cardiac and bone marrow biopsies confirmed the diagnosis of systemic light-chain amyloidosis. The chronic diarrhea was found to be due to an autonomic neuropathy of the enteric nervous system.

Published
2013

42. Deutsch-österreichische S3-Leitlinie Infarktbedingter kardiogener Schock. Diagnose, Monitoring und Therapie

Author

Werdan, Karl, Ruß, Martin A., Buerke, Michael, Engelmann, Lothar, Ferrari, Markus Wolfagang, Friedrich, Ivar, Geppert, Alexander, Graf, Jürgen, Hindricks, Gerhard, Janssens, Uwe, Pieske, Burkert Mathias, Prondzinsky, Roland, Reith, Sebastian, Trappe, Hans Joachim, Zehender, Manfred K., Zerkowski, Hans Reinhard, Zeymer, Uwe, Adams, Hans Anton, Briegel, Josef, Delle-Karth, Georg, Schöndube, Friedrich Albert, Schwaab, Bernhard, Bode, Christoph, Christoph, Arnd, Erbel, Raimund, Fuhrmann, Joerg T., Strasser, Ruth H., Figulla, Hans Reiner, Görge, Günther, Schmitt, Dierck V., Schüler, Gerhard C., Silber, Rolf Edgar, Tebbe, Ullrich, and Zwißler, Bernhard C.

Subjects
Medizin, Cardiology and Cardiovascular Medicine
Published
2011

Catalog

Books, media, physical & digital resources
See catalog results