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3. Education and Information to Improve Adherence to Screening for Breast, Colorectal, and Cervical Cancer—Lessons Learned during the COVID-19 Pandemic.

Author

Gabriele, Raimondo, Campagnol, Monica, Sapienza, Paolo, Borrelli, Valeria, Di Marzo, Luca, and Sterpetti, Antonio V.

Subjects
TUMOR surgery, PATIENT compliance, HEALTH literacy, MORTALITY, CERVIX uteri tumors, PATIENTS, T-test (Statistics), HEALTH, EARLY detection of cancer, BREAST tumors, HOSPITAL admission & discharge, INTERVIEWING, SOCIOECONOMIC status, SOCIOECONOMIC disparities in health, EDUCATIONAL outcomes, INFORMATION resources, COLORECTAL cancer, HOSPITALS, CHI-squared test, DESCRIPTIVE statistics, RURAL conditions, HEALTH education, TUMORS, COMPARATIVE studies, COVID-19 pandemic, SOCIAL classes, EDUCATIONAL attainment, PREVENTIVE health services
Abstract

Simple Summary: Screening for breast, colorectal, and cervical cancer is correlated with diagnosis at an earlier stage, less extensive surgery, and reduced mortality and fewer complications. Adherence rates to cancer screening are lower for individuals with low socio-economic conditions and educational attainment. These social disparities are only partially reduced by free screening through national initiatives. Education and information and appropriate expenditure for preventive care have the potentials to increase adherence to screening for colorectal, breast, and cervical cancer with the possibility of reduced cancer mortality. The findings of our study highlight the importance of the implementation of nationally organized screening programs for several other types of cancers that are often detected after the occurrence of symptoms. Nationally organized screening programs for several types of cancers, like esophageal, gastric, and pancreatic cancer, in regions with a high prevalence may increase the possibility of diagnosis at earlier stages and improved early and late results. The objective of this study was to determine the correlation between adherence to cancer screening programs and earlier diagnosis of the 14 most common types of cancers in the adult population, before and during the COVID-19 pandemic. National data concerning number of admissions and operations in Italy for adult patients admitted with oncologic problems during the COVID-19 pandemic (2020 to 2022) and in the pre-pandemic period (2015 to 2019) were analyzed. We selected 14 types of cancer that present the most common indications for surgery in Italy. This study included 1,365,000 adult patients who had surgery for the 14 most common types of cancer in the period 2015–2022, and interviews concerning adherence rates to screening for breast, colorectal, and cervical cancer were conducted for 133,455 individuals. A higher decrease in the number of operations for the 14 types of cancer (−45%) was registered during the first three acute phases of the pandemic, and it was more evident for screenable cancers like breast, colorectal, and cervical cancer (p < 0.001). During the first year of the COVID-19 pandemic, the number of screened individuals for breast, colorectal, and cervical cancer decreased by 33.8% (from 7,507,893 to 4,969,000) and the number of diagnoses and operations for these three types of cancer decreased by 10.5% (from 107,656 to 96,405). The increase and return to normality of the number of screened individuals in the last year of the pandemic (2022) and in the first post-pandemic year (2023) was associated with a return to the pre-pandemic levels of diagnoses and operations. The adherence rates were lower for individuals living in rural areas, with low socio-economic status, and unmarried persons; however, the most statistically significant factor for reduced adherence was a lower level of educational attainment. Free screening through nationally organized programs reduced social disparities. There were no significant differences between the pre-pandemic and pandemic periods for several types of cancers (stomach, esophagus, pancreas, liver) that are diagnosed for the occurrence of symptoms and for which nationally organized programs might increase the possibility of earlier diagnosis and improved clinical outcomes. Education, information, and appropriate expenditure for preventive care have the potential to reduce cancer mortality. Nationally organized screening programs for several types of cancers, which are often detected for the occurrence of symptoms, may increase the possibility of diagnosis at earlier stages. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index

Author

Sterpetti, Antonio V., Tesolato, Sofía, González-Gamo, Daniel, Barabash Bustelo, Ana, Claver, Paula, De La-Serna Esteban, Sofía Cristina, Domínguez Serrano, María Inmaculada, Dziakova, Jana, Juan Chocano, María Del Carmen De, Torres García, Antonio José, Iniesta Serrano, María Pilar, Sterpetti, Antonio V., Tesolato, Sofía, González-Gamo, Daniel, Barabash Bustelo, Ana, Claver, Paula, De La-Serna Esteban, Sofía Cristina, Domínguez Serrano, María Inmaculada, Dziakova, Jana, Juan Chocano, María Del Carmen De, Torres García, Antonio José, and Iniesta Serrano, María Pilar

Abstract

Colorectal cancer (CRC) is one of the main tumor pathologies in our society considering its incidence and mortality. Various authors have linked the development of CRC with overweight and obesity. However, no molecular markers have been defined to connect both pathologies and that can be assessed in serum for diagnostic and/or prognostic purposes. The main objective of this work is to analyze and correlate the expression levels of four miRNAs previously associated with cancer and/or obesity in patients affected by CRC, as well as in a control group without cancer, considering the body mass index (BMI) of subjects. The main novelty of this study consists in the variety of samples investigated: adipose tissues, omental and subcutaneous; serum; and tumor and non-tumor tissues in the case of CRC patients. Results conclude about the utility mainly of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC., Carlos III Institute of Health (Ministerio de Economía y Competitividad), Spain, European Union through the European Regional Development Fund (ERDF) ‘A way to make Europe’, Depto. de Bioquímica y Biología Molecular, Depto. de Medicina, Depto. de Cirugía, Fac. de Farmacia, Fac. de Medicina, TRUE, pub

Published
2023

32. Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL

Author

Fiori, Enrico, primary, Crocetti, Daniele, additional, Sapienza, Paolo, additional, Cirocchi, Roberto, additional, Sterpetti, Antonio V., additional, Miccini, Michelangelo, additional, Accordino, Marcello, additional, Costi, Silvano, additional, Lapolla, Pierfrancesco, additional, Mingoli, Andrea, additional, De Toma, Giorgio, additional, and Lamazza, Antonietta, additional

Published
2021
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33. Colon or Rectal Stent Positioning for Advanced Cancer Influences Quality of Life: A Critical Point of View

Author

FIORI, ENRICO, primary, CROCETTI, DANIELE, additional, SAPIENZA, PAOLO, additional, MICCINI, MICHELANGELO, additional, CIROCCHI, ROBERTO, additional, STERPETTI, ANTONIO V., additional, DE FELICE, FRANCESCA, additional, COSTI, SILVANO, additional, BRACHINI, GIOIA, additional, MINGOLI, ANDREA, additional, LAMAZZA, ANTONIETTA, additional, and DE TOMA, GIORGIO, additional

Published
2021
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35. Current Status of the Self-Expandable Metal Stent as a Bridge to Surgery Versus Emergency Surgery in Colorectal Cancer: Results from an Updated Systematic Review and Meta-Analysis of the Literature

Author

Cirocchi, Roberto, primary, Arezzo, Alberto, additional, Sapienza, Paolo, additional, Crocetti, Daniele, additional, Cavaliere, Davide, additional, Solaini, Leonardo, additional, Ercolani, Giorgio, additional, Sterpetti, Antonio V., additional, Mingoli, Andrea, additional, and Fiori, Enrico, additional

Published
2021
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41. Surgical oncology in the pandemic. Lessons learned and future perspectives

Author

Sterpetti, Antonio V.

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, Risk Assessment, Article, Postoperative Complications, COVID19 Pandemic, Surgical oncology, Neoplasms, Pandemic, medicine, Humans, Intensive care medicine, SARS-CoV-2, business.industry, Surgical oncolgoy, Patient Selection, COVID-19, Endoscopy, General Medicine, Length of Stay, Telemedicine, Intensive Care Units, Surgical Oncology, Oncology, Elective Surgical Procedures, Surgery, business, Delivery of Health Care
Published
2020
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50. Sealed rupture of abdominal aortic aneurysms

Author

Sterpetti, Antonio V., Blair, Elizabeth A., Schultz, Richard D., Feldhaus, Richard J., Cisternino, Silvestro, and Chasan, Paul

Subjects
Abdominal aneurysm, Aortic aneurysms -- Complications, Health
Abstract

The diagnosis of a ruptured abdominal aortic aneurysm (tearing of the localized area of dilated aortic wall) is easily made on the basis of abdominal or back pain, shock and a pulsating mass in the abdomen. A chronic sealed rupture of an abdominal aortic aneurysm, an unusual condition in which the aneurysm ruptures but is contained, is difficult to diagnose. However, if left untreated, a sealed rupture may re-open, causing massive hemorrhage. Sixteen patients with chronic sealed rupture of an abdominal aortic aneurysm were evaluated. The study group included 15 men and 1 woman with an average age of 72. Two patients had symptoms of acute aneurysm rupture and were treated surgically; in addition to the hemorrhaging aneurysm, a sealed rupture was also found. One patient died. The remaining patients were treated surgically with good results and remission of their symptoms. A rupture can seal itself off if there is slow bleeding and a high degree of resistance from the surrounding tissue. Although hypertension is considered to be a risk factor for rupture of an aneurysm, normal blood pressure may increase the risk of the rupture sealing. A small perforation is also more easily contained. The mechanism of sealing in small aneurysms appears to involve an aortic wall that is still quite strong, and a limited tear. The site of the tear in the aortic aneurysm was most often (10 patients) posterior and adjacent to the vertebrae; the bleeding was most likely walled off by the bony structure. In elderly patients who complain of unexplained back or inguinal (groin) pain, the diagnosis of sealed rupture of an abdominal aneurysm should be considered. Computed tomography is helpful in making the diagnosis. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

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