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475 results on '"Sportoletti, Paolo"'

1. Genetic variation in NOTCH1 is associated with overweight and obesity in Brazilian elderly

Author

Silva Barcelos, Estevão Carlos, Naslavsky, Michel Satya, Fernandes, Izadora Silveira, Scliar, Marilia Oliveira, Yamamoto, Guilherme Lopes, Wang, Jaqueline Yu Ting, Bride, Laís, de Sousa, Valdemir Pereira, Pimassoni, Lucia Helena Sagrillo, Sportoletti, Paolo, de Paula, Flavia, von Zeidler, Sandra Ventorin, Duarte, Yeda Aparecida Oliveira, Passos-Bueno, Maria Rita, Zatz, Mayana, and Errera, Flávia Imbroisi Valle

Published
2024
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2. Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY

Author

Chatzikonstantinou, Thomas, Scarfò, Lydia, Karakatsoulis, Georgios, Minga, Eva, Chamou, Dimitra, Iacoboni, Gloria, Kotaskova, Jana, Demosthenous, Christos, Smolej, Lukas, Mulligan, Stephen, Alcoceba, Miguel, Al-Shemari, Salem, Aurran-Schleinitz, Thérèse, Bacchiarri, Francesca, Bellido, Mar, Bijou, Fontanet, Calleja, Anne, Medina, Angeles, Khan, Mehreen Ali, Cassin, Ramona, Chatzileontiadou, Sofia, Collado, Rosa, Christian, Amy, Davis, Zadie, Dimou, Maria, Donaldson, David, Santos, Gimena Dos, Dreta, Barbara, Efstathopoulou, Maria, El-Ashwah, Shaimaa, Enrico, Alicia, Fresa, Alberto, Galimberti, Sara, Galitzia, Andrea, García-Serra, Rocío, Gimeno, Eva, González-Gascón-y-Marín, Isabel, Gozzetti, Alessandro, Guarente, Valerio, Guieze, Romain, Gogia, Ajay, Gupta, Ritu, Harrop, Sean, Hatzimichael, Eleftheria, Herishanu, Yair, Hernández-Rivas, José-Ángel, Inchiappa, Luca, Jaksic, Ozren, Janssen, Susanne, Kalicińska, Elżbieta, Laribi, Kamel, Karakus, Volkan, Kater, Arnon P., Kho, Bonnie, Kislova, Maria, Konstantinou, Eliana, Koren-Michowitz, Maya, Kotsianidis, Ioannis, Kreitman, Robert J., Labrador, Jorge, Lad, Deepesh, Levin, Mark-David, Levy, Ilana, Longval, Thomas, Lopez-Garcia, Alberto, Marquet, Juan, Martin-Rodríguez, Lucia, Maynadié, Marc, Maslejova, Stanislava, Mayor-Bastida, Carlota, Mihaljevic, Biljana, Milosevic, Ivana, Miras, Fatima, Moia, Riccardo, Morawska, Marta, Murru, Roberta, Nath, Uttam Kumar, Navarro-Bailón, Almudena, Oliveira, Ana C., Olivieri, Jacopo, Oscier, David, Panovska-Stavridis, Irina, Papaioannou, Maria, Papajík, Tomas, Kubova, Zuzana, Phumphukhieo, Punyarat, Pierie, Cheyenne, Puiggros, Anna, Rani, Lata, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Daniel de Deus Santos, Marcos, Schipani, Mattia, Schiwitza, Annett, Shen, Yandong, Simkovic, Martin, Smirnova, Svetlana, Abdelrahman Soliman, Dina Sameh, Spacek, Martin, Tadmor, Tamar, Tomic, Kristina, Tse, Eric, Vassilakopoulos, Theodoros, Visentin, Andrea, Vitale, Candida, von Tresckow, Julia, Vrachiolias, George, Vukovic, Vojin, Walewska, Renata, Wasik-Szczepanek, Ewa, Xu, Zhenshu, Yagci, Munci, Yañez, Lucrecia, Yassin, Mohamed, Zuchnicka, Jana, Angelopoulou, Maria, Antic, Darko, Biderman, Bella, Catherwood, Mark, Claus, Rainer, Coscia, Marta, Cuneo, Antonio, Demirkan, Fatih, Espinet, Blanca, Gaidano, Gianluca, Kalashnikova, Olga B., Laurenti, Luca, Nikitin, Eugene, Pangalis, Gerassimos A., Panagiotidis, Panagiotis, Popov, Viola Maria, Pospisilova, Sarka, Sportoletti, Paolo, Stavroyianni, Niki, Tam, Constantine, Trentin, Livio, Chatzidimitriou, Anastasia, Bosch, Francesc, Doubek, Michael, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2023
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3. Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML

Author

Pianigiani, Giulia, Gagliardi, Andrea, Mezzasoma, Federica, Rocchio, Francesca, Tini, Valentina, Bigerna, Barbara, Sportoletti, Paolo, Caruso, Simona, Marra, Andrea, Peruzzi, Sara, Petito, Eleonora, Spinozzi, Giulio, Shacham, Sharon, Landesman, Yosef, Quintarelli, Concetta, Gresele, Paolo, Locatelli, Franco, Martelli, Maria Paola, Falini, Brunangelo, and Brunetti, Lorenzo

Published
2022
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4. Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL

Author

Antic, Darko, Milic, Natasa, Chatzikonstantinou, Thomas, Scarfò, Lydia, Otasevic, Vladimir, Rajovic, Nina, Allsup, David, Alonso Cabrero, Alejandro, Andres, Martin, Baile Gonzales, Monica, Capasso, Antonella, Collado, Rosa, Cordoba, Raul, Cuéllar-García, Carolina, Correa, Juan Gonzalo, De Paoli, Lorenzo, De Paolis, Maria Rosaria, Del Poeta, Giovanni, Dimou, Maria, Doubek, Michael, Efstathopoulou, Maria, El-Ashwah, Shaimaa, Enrico, Alicia, Espinet, Blanca, Farina, Lucia, Ferrari, Angela, Foglietta, Myriam, Lopez-Garcia, Alberto, García-Marco, José A., García-Serra, Rocío, Gentile, Massimo, Gimeno, Eva, da Silva, Maria Gomes, Gutwein, Odit, Hakobyan, Yervand K., Herishanu, Yair, Hernández-Rivas, José Ángel, Herold, Tobias, Itchaki, Gilad, Jaksic, Ozren, Janssens, Ann, Kalashnikova, Olga B., Kalicińska, Elżbieta, Kater, Arnon P., Kersting, Sabina, Koren-Michowitz, Maya, Labrador, Jorge, Lad, Deepesh, Laurenti, Luca, Fresa, Alberto, Levin, Mark-David, Mayor Bastida, Carlota, Malerba, Lara, Marasca, Roberto, Marchetti, Monia, Marquet, Juan, Mihaljevic, Biljana, Milosevic, Ivana, Mirás, Fatima, Morawska, Marta, Motta, Marina, Munir, Talha, Murru, Roberta, Nunes, Raquel, Olivieri, Jacopo, Pavlovsky, Miguel Arturo, Piskunova, Inga, Popov, Viola Maria, Quaglia, Francesca Maria, Quaresmini, Giulia, Reda, Gianluigi, Rigolin, Gian Matteo, Shrestha, Amit, Šimkovič, Martin, Smirnova, Svetlana, Špaček, Martin, Sportoletti, Paolo, Stanca, Oana, Stavroyianni, Niki, Te Raa, Doreen, Tomic, Kristina, Tonino, Sanne, Trentin, Livio, Van Der Spek, Ellen, van Gelder, Michel, Varettoni, Marzia, Visentin, Andrea, Vitale, Candida, Vukovic, Vojin, Wasik-Szczepanek, Ewa, Wróbel, Tomasz, Segundo, Lucrecia Yáñez San, Yassin, Mohamed, Coscia, Marta, Rambaldi, Alessandro, Montserrat, Emili, Foà, Robin, Cuneo, Antonio, Carrier, Marc, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2022
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5. Management of infections for patient treated with ibrutinib in clinical practice.

Author

Baratè, Claudia, Scortechini, Ilaria, Ciofini, Sara, Picardi, Paola, Angeletti, Ilaria, Loscocco, Federica, Sanna, Alessandro, Isidori, Alessandro, and Sportoletti, Paolo

Subjects
BRUTON tyrosine kinase, CHRONIC lymphocytic leukemia, MEDICAL personnel, PROTEIN-tyrosine kinase inhibitors, THERAPEUTICS
Abstract

Ibrutinib, a highly effective inhibitor of the Bruton tyrosine kinase, has significantly transformed the therapeutic approach in chronic lymphocytic leukemia (CLL). Despite these advancements, the disease continues to be characterized by immune dysfunction and increased susceptibility to infections, with mortality rates from infections showing no significant improvement over the past few decades. Therefore, timely prevention, recognition, and treatment of infections remains an important aspect of the standard management of a patient with CLL. A panel of hematologists with expertise in CLL met to discuss existing literature and clinical insights for the management of infectious in CLL undergoing ibrutinib treatment. Despite not being a fully comprehensive review on the topic, this work provides a set of practical recommendations that can serve as a guide to healthcare professionals who manage these patients in their daily clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Nanotechnology Advances in the Detection and Treatment of Lymphoid Malignancies.

Author

Adamo, Francesco Maria, De Falco, Filomena, Dorillo, Erica, Sorcini, Daniele, Stella, Arianna, Esposito, Angela, Arcaleni, Roberta, Rosati, Emanuela, and Sportoletti, Paolo

Subjects
DISEASE management, INDIVIDUALIZED medicine, HEMATOLOGIC malignancies, SYMPTOMS, NANOTECHNOLOGY
Abstract

Lymphoid malignancies are complex diseases with distinct biological behaviors, clinical presentations, and treatment responses. Ongoing research and advancements in biotechnology enhance the understanding and management of these malignancies, moving towards more personalized approaches for diagnosis and treatment. Nanotechnology has emerged as a promising tool to improve some limitations of conventional diagnostics as well as treatment strategies for lymphoid malignancies. Nanoparticles (NPs) offer unique advantages such as enhanced multimodal detection, drug delivery, and targeted therapy capabilities, with the potential to improve precision medicine and patient outcomes. Here, we comprehensively examine the current landscape of nanoconstructs applied in the management of lymphoid disease. Through a comprehensive analysis of preclinical studies, we highlight the translational potential of NPs in revolutionizing the field of hematological malignancies, with a specific focus on lymphoid neoplasms. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Do age, fitness, and concomitant medications influence management and outcomes of patients with CLL treated with ibrutinib?

Author

Tedeschi, Alessandra, Frustaci, Anna Maria, Mauro, Francesca Romana, Chiarenza, Annalisa, Coscia, Marta, Ciolli, Stefania, Reda, Gianluigi, Laurenti, Luca, Varettoni, Marzia, Murru, Roberta, Baratè, Claudia, Sportoletti, Paolo, Greco, Antonino, Borella, Chiara, Rossi, Valentina, Deodato, Marina, Biagi, Annalisa, Zamprogna, Giulia, Pelle, Angelo Curto, Lapietra, Gianfranco, Vitale, Candida, Morelli, Francesca, Cassin, Ramona, Fresa, Alberto, Cavalloni, Chiara, Postorino, Massimiliano, Ielo, Claudia, Cairoli, Roberto, Di Raimondo, Francesco, Montillo, Marco, and Del Poeta, Giovanni

Published
2021
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10. Real-World Outcome of Treatment with Single-Agent Ibrutinib in Italian Patients with Chronic Lymphocytic Leukemia: Final Results of the EVIdeNCE Study

Author

Mauro, Francesca Romana, primary, Scalzulli, Potito Rosario, additional, Scarfò, Lydia, additional, Minoia, Carla, additional, Murru, Roberta, additional, Sportoletti, Paolo, additional, Frigeri, Ferdinando, additional, Albano, Francesco, additional, Di Renzo, Nicola, additional, Sanna, Alessandro, additional, Laurenti, Luca, additional, Massaia, Massimo, additional, Cassin, Ramona, additional, Coscia, Marta, additional, Patti, Caterina, additional, Pennese, Elsa, additional, Tafuri, Agostino, additional, Chiarenza, Annalisa, additional, Galieni, Piero, additional, Perbellini, Omar, additional, Selleri, Carmine, additional, Califano, Catello, additional, Ferrara, Felicetto, additional, Cuneo, Antonio, additional, Murineddu, Marco, additional, Palumbo, Gaetano, additional, Scortechini, Ilaria, additional, Tedeschi, Alessandra, additional, Trentin, Livio, additional, Varettoni, Marzia, additional, Pane, Fabrizio, additional, Liberati, Anna Marina, additional, Merli, Francesco, additional, Morello, Lucia, additional, Musuraca, Gerardo, additional, Tani, Monica, additional, Ibatici, Adalberto, additional, Regazzoni, Giulia, additional, Di Candia, Michele, additional, Palma, Maria, additional, Arienti, Danilo, additional, and Molica, Stefano, additional

Published
2024
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12. Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia

Author

Montanaro, Anna, Kitara, Samuel, Cerretani, Elisa, Marchesini, Matteo, Rompietti, Chiara, Pagliaro, Luca, Gherli, Andrea, Su, Angela, Minchillo, Maria Laura, Caputi, Mariafrancesca, Fioretzaki, Rodanthi, Lorusso, Bruno, Ross, Linda, Alexe, Gabriela, Masselli, Elena, Marozzi, Marina, Rizzi, Federica Maria Angela, La Starza, Roberta, Mecucci, Cristina, Xiong, Yan, Jin, Jian, Falco, Angela, Knoechel, Birgit, Aversa, Franco, Candini, Olivia, Quaini, Federico, Sportoletti, Paolo, Stegmaier, Kimberly, and Roti, Giovanni

Published
2022
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13. Venetoclax infectious risk score to identify patients with chronic lymphocytic leukemia at high infectious risk during venetoclax treatment: A multicenter SEIFEM study

Author

Autore, Francesco, Visentin, Andrea, Deodato, Marina, Vitale, Candida, Galli, Eugenio, Fresa, Alberto, Fazzi, Rita, Sanna, Alessandro, Olivieri, Jacopo, Scortechini, Ilaria, Del Principe, Maria Ilaria, Sportoletti, Paolo, Schiattone, Luana, Maschio, Nilla, Facchinelli, Davide, Marchesi, Francesco, Coscia, Marta, Tedeschi, Alessandra, Trentin, Livio, Innocenti, Idanna, Candoni, Anna, Busca, Alessandro, Pagano, Livio, Laurenti, Luca, Pagano, Livio (ORCID:0000-0001-8287-928X), Laurenti, Luca (ORCID:0000-0002-8327-1396), Autore, Francesco, Visentin, Andrea, Deodato, Marina, Vitale, Candida, Galli, Eugenio, Fresa, Alberto, Fazzi, Rita, Sanna, Alessandro, Olivieri, Jacopo, Scortechini, Ilaria, Del Principe, Maria Ilaria, Sportoletti, Paolo, Schiattone, Luana, Maschio, Nilla, Facchinelli, Davide, Marchesi, Francesco, Coscia, Marta, Tedeschi, Alessandra, Trentin, Livio, Innocenti, Idanna, Candoni, Anna, Busca, Alessandro, Pagano, Livio, Laurenti, Luca, Pagano, Livio (ORCID:0000-0001-8287-928X), and Laurenti, Luca (ORCID:0000-0002-8327-1396)

Abstract

N/A

Published
2024

14. Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia

Author

Marchesini, Matteo, Gherli, Andrea, Montanaro, Anna, Patrizi, Laura, Sorrentino, Claudia, Pagliaro, Luca, Rompietti, Chiara, Kitara, Samuel, Heit, Sabine, Olesen, Claus E., Møller, Jesper V., Savi, Monia, Bocchi, Leonardo, Vilella, Rocchina, Rizzi, Federica, Baglione, Marilena, Rastelli, Giorgia, Loiacono, Caterina, La Starza, Roberta, Mecucci, Cristina, Stegmaier, Kimberly, Aversa, Franco, Stilli, Donatella, Lund Winther, Anne-Marie, Sportoletti, Paolo, Bublitz, Maike, Dalby-Brown, William, and Roti, Giovanni

Published
2020
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15. The evolving landscape of COVID‐19 and post‐COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL

Author

Visentin, Andrea, primary, Chatzikonstantinou, Thomas, additional, Scarfò, Lydia, additional, Kapetanakis, Anargyros, additional, Demosthenous, Christos, additional, Karakatsoulis, Georgios, additional, Minga, Eva, additional, Chamou, Dimitra, additional, Allsup, David, additional, Cabrero, Alejandro Alonso, additional, Andres, Martin, additional, Antic, Darko, additional, Baile, Mónica, additional, Baliakas, Panagiotis, additional, Besikli‐Dimou, Sotiria, additional, Bron, Dominique, additional, Chatzileontiadou, Sofia, additional, Cordoba, Raul, additional, Correa, Juan‐Gonzalo, additional, Cuéllar‐García, Carolina, additional, De Paoli, Lorenzo, additional, De Paolis, Maria Rosaria, additional, Delgado, Julio, additional, Dimou, Maria, additional, Donaldson, David, additional, Catherwood, Mark, additional, Doubek, Michael, additional, Efstathopoulou, Maria, additional, Eichhorst, Barbara, additional, Elashwah, Salma, additional, Enrico, Alicia, additional, Espinet, Blanca, additional, Farina, Lucia, additional, Ferrari, Angela, additional, Foglietta, Myriam, additional, Frederiksen, Henrik, additional, Fürstenau, Moritz, additional, García‐Marco, José A., additional, García‐Serra, Rocío, additional, Collado, Rosa, additional, Gentile, Massimo, additional, Gimeno, Eva, additional, Glenthøj, Andreas, additional, da Silva, Maria Gomes, additional, Hakobyan, Yervand K., additional, Herishanu, Yair, additional, Hernández‐Rivas, José Ángel, additional, Herold, Tobias, additional, Innocenti, Idanna, additional, Itchaki, Gilad, additional, Jaksic, Ozren, additional, Janssens, Ann, additional, Kalashnikova, Оlga B., additional, Kalicińska, Elżbieta, additional, Kater, Arnon P., additional, Kersting, Sabina, additional, Labrador, Jorge, additional, Lad, Deepesh, additional, Laurenti, Luca, additional, Levin, Mark‐David, additional, Lista, Enrico, additional, Lopez‐Garcia, Alberto, additional, Malerba, Lara, additional, Marasca, Roberto, additional, Marchetti, Monia, additional, Marquet, Juan, additional, Mattsson, Mattias, additional, Mauro, Francesca R., additional, Morawska, Marta, additional, Motta, Marina, additional, Munir, Talha, additional, Murru, Roberta, additional, Niemann, Carsten U., additional, Rodrigues, Raquel Nunes, additional, Olivieri, Jacopo, additional, Orsucci, Lorella, additional, Papaioannou, Maria, additional, Pavlovsky, Miguel Arturo, additional, Piskunova, Inga, additional, Popov, Viola Maria, additional, Quaglia, Francesca Maria, additional, Quaresmini, Giulia, additional, Qvist, Kristian, additional, Rigolin, Gian Matteo, additional, Ruchlemer, Rosa, additional, Šimkovič, Martin, additional, Špaček, Martin, additional, Sportoletti, Paolo, additional, Stanca, Oana, additional, Tadmor, Tamar, additional, Capasso, Antonella, additional, Del Poeta, Giovanni, additional, Gutwein, Odit, additional, Karlsson, Linda Katharina, additional, Milosevic, Ivana, additional, Mirás, Fatima, additional, Reda, Gianluigi, additional, Saghumyan, Gevorg, additional, Shrestha, Amit, additional, Te Raa, Doreen, additional, Tonino, Sanne H., additional, Van Der Spek, Ellen, additional, van Gelder, Michel, additional, van Kampen, Roel, additional, Wasik‐Szczepanek, Ewa, additional, Wróbel, Tomasz, additional, Segundo, Lucrecia Yáñez San, additional, Yassin, Mohamed, additional, Pocali, Barbara, additional, Vandenberghe, Elisabeth, additional, Iyengar, Sunil, additional, Varettoni, Marzia, additional, Vitale, Candida, additional, Coscia, Marta, additional, Rambaldi, Alessandro, additional, Montserrat, Emili, additional, Cuneo, Antonio, additional, Stavroyianni, Niki, additional, Trentin, Livio, additional, Stamatopoulos, Kostas, additional, and Ghia, Paolo, additional

Published
2023
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16. NOTCH1-mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential

Author

Silva Barcelos, Estevão Carlos, primary, Rompietti, Chiara, additional, Adamo, Francesco Maria, additional, Dorillo, Erica, additional, De Falco, Filomena, additional, Del Papa, Beatrice, additional, Baldoni, Stefano, additional, Nogarotto, Manuel, additional, Esposito, Angela, additional, Capoccia, Silvia, additional, Geraci, Clelia, additional, Sorcini, Daniele, additional, Stella, Arianna, additional, Arcaleni, Roberta, additional, Tini, Valentina, additional, Imbroisi Valle Errera, Flávia, additional, Rosati, Emanuela, additional, and Sportoletti, Paolo, additional

Published
2023
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18. P1509: CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND PREVIOUS INFECTIONS HAD IMPACT ON INFECTIOUS COMPLICATIONS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA TREATED WITH VENETOCLAX: A MULTICENTRE SEIFEM STUDY

Author

Autore, Francesco, primary, Visentin, Andrea, additional, Deodato, Marina, additional, Vitale, Candida, additional, Galli, Eugenio, additional, Fresa, Alberto, additional, Fazzi, Rita, additional, Sanna, Alessandro, additional, Olivieri, Jacopo, additional, Scortechini, Ilaria, additional, Principe, Maria Ilaria DEL, additional, Sportoletti, Paolo, additional, Schiattone, Luana, additional, Maschio, Nilla, additional, Facchinelli, Davide, additional, Coscia, Marta, additional, Tedeschi, Alessandra, additional, Trentin, Livio, additional, Innocenti, Idanna, additional, Candoni, Anna, additional, Busca, Alessandro, additional, Pagano, Livio, additional, and Laurenti, Luca, additional

Published
2023
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19. P686: REAL-WORLD EFFICACY PROFILE OF ASCIMINIB IN AN ITALIAN, MULTI-RESISTANT CHRONIC-PHASE CHRONIC MYELOID LEUKEMIA (CP-CML) PATIENT POPULATION

Author

Breccia, Massimo, primary, Russo Rossi, Antonella, additional, Giai, Valentina, additional, Martino, Bruno, additional, Fava, Carmen, additional, Annunziata, Mario, additional, Abruzzese, Elisabetta, additional, Binotto, Gianni, additional, Baratè, Claudia, additional, Pio Nardozza, Aurelio, additional, Misto, Alessandra, additional, Coco, Paola, additional, Calafiore, Valeria, additional, Cristina Carraro, Maria, additional, Cattina, Federica, additional, Cavazzini, Francesco, additional, Teresa Corsetti, Maria, additional, Crucitti, Lara, additional, Crugnola, Monica, additional, Ditonno, Paolo, additional, DI Veroli, Ambra, additional, Ermacora, Anna, additional, Ferrara, Felicetto, additional, Genua, Angelo, additional, Gozzini, Antonella, additional, Impera, Stefana, additional, Iurlo, Alessandra, additional, Levato, Luciano, additional, Luciano, Luigiana, additional, Cristina Miggiano, Maria, additional, De Gobbi, Marco, additional, Santoro, Marco, additional, Scappini, Barbara, additional, Rita Scortechini, Anna, additional, Patriarca, Andrea, additional, Rosati, Serena, additional, Russo, Sabina, additional, Sancetta, Rosaria, additional, Sanpaolo, Grazia, additional, Maria Santeramo, Teresa, additional, Sibilla, Silvia, additional, Sorà, Federica, additional, Sportoletti, Paolo, additional, Stagno, Fabio, additional, Trabacchi, Elena, additional, and Castagnetti, Fausto, additional

Published
2023
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20. P1038: TL-895, A FIRST-IN-CLASS, COVALENT BRUTON TYROSINE KINASE INHIBITOR (BTKI) FOR THE TREATMENT OF MYELOFIBROSIS (MF) PATIENTS (PTS) WITH SEVERE THROMBOCYTOPENIA (PLATELETS (PLTS) <50 K/UL)

Author

Loschi, Michael, primary, Rejto, Laszlo, additional, Chuah, Hun, additional, Caramella, Marianna, additional, Hernández Rivas, Jesus, additional, Sportoletti, Paolo, additional, Dubruille, Viviane, additional, Bellesso, Marcelo, additional, Gröpper, Stefanie, additional, Crodel, Carl, additional, Qamoos, Hope, additional, Socotch, Ashley, additional, Huang, Zhuying, additional, Wall, Sarah, additional, Mcgreivy, Jesse, additional, Rothbaum, Wayne P., additional, Verstovsek, Srdan, additional, and Palandri, Francesca, additional

Published
2023
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21. P597: XPO1 MUTATIONS IDENTIFY EARLY STAGE CLL CHARACTERIZED BY SHORTER TIME TO FIRST TREATMENT AND ENHANCED BCR SIGNALING

Author

Talotta, Donatella, primary, Moia, Riccardo, additional, Terzi DI Bergamo, Lodovico, additional, Bomben, Riccardo, additional, Forestieri, Gabriela, additional, Spina, Valeria, additional, Bruscaggin, Alessio, additional, Cosentino, Chiara, additional, Almasri, Mohammad, additional, Dondolin, Riccardo, additional, Bittolo, Tamara, additional, Zucchetto, Antonella, additional, Baldoni, Stefano, additional, Del Giudice, Ilaria, additional, Romana Mauro, Francesca, additional, Maffei, Rossana, additional, Chiarenza, Annalisa, additional, Tafuri, Agostino, additional, Laureana, Roberta, additional, Ilaria Del Principe, Maria, additional, Zaja, Francesco, additional, D’arena, Giovanni, additional, Olivieri, Jacopo, additional, Rasi, Silvia, additional, Mahmoud, Abdurraouf, additional, Al Essa, Wael, additional, Awikeh, Bassel, additional, Kogila, Sreekar, additional, Bellia, Matteo, additional, Mouhssine, Samir, additional, Sportoletti, Paolo, additional, Marasca, Roberto, additional, Scarfò, Lydia, additional, Ghia, Paolo, additional, Gattei, Valter, additional, Foà, Robin, additional, Rossi, Davide, additional, and Gaidano, Gianluca, additional

Published
2023
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22. S149: OTHER MALIGNANCIES IN THE HISTORY OF CLL: THE FINAL ANALYSIS OF THE INTERNATIONAL MULTICENTER STUDY CONDUCTED BY ERIC, IN HARMONY.

Author

Chatzikonstantinou, Thomas, primary, Scarfò, Lydia, additional, Karakatsoulis, Georgios, additional, Minga, Eva, additional, Chamou, Dimitra, additional, Iacoboni, Gloria, additional, Kotaskova, Jana, additional, Demosthenous, Christos, additional, Alcoceba, Miguel, additional, Al-Shemari, Salem, additional, Aurran-Schleinitz, Thérèse, additional, Bacchiarri, Francesca, additional, Bellido, Mar, additional, Bijou, Fontanet, additional, Calleja, Anne, additional, Medina, Angeles, additional, Khan, Mehreen Ali, additional, Cassin, Ramona, additional, Chatzileontiadou, Sofia, additional, Collado, Rosa, additional, Davis, Zadie, additional, Dimou, Maria, additional, Donaldson, David, additional, Santos, Gimena Dos, additional, Dreta, Barbara, additional, Efstathopoulou, Maria, additional, El-Ashwah, Shaimaa, additional, Enrico, Alicia, additional, Fresa, Alberto, additional, Galimberti, Sara, additional, Galitzia, Andrea, additional, García-Serra, Rocío, additional, Gimeno, Eva, additional, González-Gascón-Y-Marín, Isabel, additional, Gozzetti, Alessandro, additional, Guarente, Valerio, additional, Guieze, Romain, additional, Gogia, Ajay, additional, Gupta, Ritu, additional, Harrop, Sean, additional, Hatzimichael, Eleftheria, additional, Herishanu, Yair, additional, Hernández-Rivas, José-Ángel, additional, Inchiappa, Luca, additional, Jaksic, Ozren, additional, Janssen, Susanne, additional, Kalicińska, Elżbieta, additional, Kamel, Laribi, additional, Karakus, Volkan, additional, Kater, Arnon P, additional, Kho, Bonnie, additional, Kislova, Maria, additional, Konstantinou, Εliana, additional, Koren-Michowitz, Maya, additional, Kotsianidis, Ioannis, additional, Kreitman, Robert J, additional, Labrador, Jorge, additional, Lad, Deepesh, additional, Levin, Mark-David, additional, Levy, Ilana, additional, Longval, Thomas, additional, Lopez-Garcia, Alberto, additional, Marquet, Juan, additional, Maynadié, Marc, additional, Maslejova, Stanislava, additional, Mayor-Bastida, Carlota, additional, Mihaljevic, Biljana, additional, Milosevic, Ivana, additional, Miras, Fatima, additional, Moia, Riccardo, additional, Morawska, Marta, additional, Murru, Roberta, additional, Nath, Uttam Kumar, additional, Navarro-Bailón, Almudena, additional, Oliveira, Ana C., additional, Olivieri, Jacopo, additional, Oscier, David, additional, Panovska-Stavridis, Irina, additional, Papaioannou, Maria, additional, Papajík, Tomas, additional, Phumphukhieo, Punyarat, additional, Pierie, Cheyenne, additional, Puiggros, Anna, additional, Rani, Lata, additional, Reda, Gianluigi, additional, Rigolin, Gian Matteo, additional, Ronson, Aharon, additional, Ruchlemer, Rosa, additional, de Deus Santos, Marcos Daniel, additional, Schipani, Mattia, additional, Schiwitza, Annett, additional, Shen, Yandong, additional, Simkovic, Martin, additional, Smirnova, Svetlana, additional, Sameh Abdelrahman Soliman, Dina, additional, Spacek, Martin, additional, Tadmor, Tamar, additional, Tomic, Kristina, additional, Tse, Eric, additional, Vassilakopoulos, Theodoros, additional, Visentin, Andrea, additional, Vitale, Candida, additional, Tresckow, Julia von, additional, Vrachiolias, George, additional, Vukovic, Vojin, additional, Walewska, Renata, additional, Wasik-Szczepanek, Ewa, additional, Xu, Zhenshu, additional, Yagci, Munci, additional, Yañez, Lucrecia, additional, Yassin, Mohamed, additional, Zuchnicka, Jana, additional, Angelopoulou, Maria, additional, Antic, Darko, additional, Biderman, Bella, additional, Catherwood, Mark, additional, Claus, Rainer, additional, Coscia, Marta, additional, Cuneo, Antonio, additional, Demirkan, Fatih, additional, Espinet, Blanca, additional, Gaidano, Gianluca, additional, Kalashnikova, Olga, additional, Laurenti, Luca, additional, Nikitin, Eugene, additional, Pangalis, Gerassimos A., additional, Panagiotidis, Panagiotis, additional, Mulligan, Stephen, additional, Popov, Viola Maria, additional, Pospisilova, Sarka, additional, Smolej, Lukas, additional, Sportoletti, Paolo, additional, Stavroyianni, Niki, additional, Tam, Constantine, additional, Trentin, Livio, additional, Chatzidimitriou, Anastasia, additional, Bosch, Francesc, additional, Doubek, Michael, additional, Ghia, Paolo, additional, and Stamatopoulos, Kostas, additional

Published
2023
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23. PB1942: PARTIAL RESPONSE WITH LYMPHOCYTOSIS (PR-L) IS NOT APPLICABLE FOR ACALABRUTINIB. AN ITALIAN MULTICENTER EXPERIENCE OF REAL LIFE.

Author

Innocenti, Idanna, primary, Mosca, Antonio, additional, Tomasso, Annamaria, additional, Galitzia, Andrea, additional, Scarfò, Lydia, additional, Galli, Eugenio, additional, Laureana, Roberta, additional, Benintende, Giulia, additional, Mattiello, Veronica, additional, Morelli, Francesca, additional, Chiriu, Sabrina, additional, Del Principe, Maria Ilaria, additional, Zamprogna, Giulia, additional, Gentile, Massimo, additional, Fabbri, Nicole, additional, Autore, Francesco, additional, Sportoletti, Paolo, additional, Fresa, Alberto, additional, Catania, Gioacchino, additional, Coscia, Marta, additional, Tedeschi, Alessandra, additional, Sanna, Alessandro, additional, Varettoni, Marzia, additional, Ghia, Paolo, additional, Murru, Roberta, additional, and Laurenti, Luca, additional

Published
2023
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24. Therapeutic Targeting Potential of Novel Silver Nanoparticles Coated with Anti-CD20 Antibody against Chronic Lymphocytic Leukemia

Author

Adamo, Francesco Maria, primary, Silva Barcelos, Estevao Carlos, additional, De Falco, Filomena, additional, Dorillo, Erica, additional, Rompietti, Chiara, additional, Sorcini, Daniele, additional, Stella, Arianna, additional, Del Papa, Beatrice, additional, Baldoni, Stefano, additional, Esposito, Angela, additional, Geraci, Clelia, additional, Arcaleni, Roberta, additional, Pennetta, Chiara, additional, Ragonese, Francesco, additional, Moretti, Lorenzo, additional, Mameli, Mariagrazia, additional, Di Ianni, Mauro, additional, Rosati, Emanuela, additional, Fioretti, Bernard, additional, and Sportoletti, Paolo, additional

Published
2023
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25. Clinical-Grade–Expanded Regulatory T Cells Prevent Graft-versus-Host Disease While Allowing a Powerful T Cell–Dependent Graft-versus-Leukemia Effect in Murine Models

Author

Del Papa, Beatrice, Ruggeri, Loredana, Urbani, Elena, Baldoni, Stefano, Cecchini, Debora, Zei, Tiziana, Iacucci Ostini, Roberta, Crescenzi, Barbara, Carotti, Alessandra, Pierini, Antonio, Sportoletti, Paolo, Di Bartolomeo, Paolo, Falzetti, Franca, Mecucci, Cristina, Velardi, Andrea, Martelli, Massimo F., and Di Ianni, Mauro

Published
2017
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26. Validation of a survival-risk score (SRS) in relapsed/refractory CLL patients treated with idelalisib–rituximab

Author

Gentile, Massimo, Martino, Enrica Antonia, Visentin, Andrea, Coscia, Marta, Reda, Gianluigi, Sportoletti, Paolo, Mauro, Francesca Romana, Laurenti, Luca, Varettoni, Marzia, Murru, Roberta, Chiarenza, Annalisa, Vigna, Ernesto, Mendicino, Francesco, Lucia, Eugenio, Bossio, Sabrina, Recchia, Anna Grazia, Moia, Riccardo, Pietrasanta, Daniela, Loseto, Giacomo, Consoli, Ugo, Scortechini, Ilaria, Rossi, Francesca Maria, Zucchetto, Antonella, Al-Janazreh, Hamdi, Vitale, Candida, Tripepi, Giovanni, D’Arrigo, Graziella, Angeletti, Ilaria, Bomben, Riccardo, Neri, Antonino, Cutrona, Giovanna, Fronza, Gilberto, Di Raimondo, Francesco, Gaidano, Gianluca, Cuneo, Antonio, Foà, Robin, Ferrarini, Manlio, Trentin, Livio, Gattei, Valter, and Morabito, Fortunato

Published
2020
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27. Antibody Response to the SARS-CoV-2 Vaccine and COVID-19 Vulnerability during the Omicron Pandemic in Patients with CLL: Two-Year Follow-Up of a Multicenter Study

Author

Mauro, Francesca R., primary, Giannarelli, Diana, additional, Galluzzo, Clementina M., additional, Visentin, Andrea, additional, Frustaci, Anna M., additional, Sportoletti, Paolo, additional, Vitale, Candida, additional, Reda, Gianluigi, additional, Gentile, Massimo, additional, Levato, Luciano, additional, Murru, Roberta, additional, Armiento, Daniele, additional, Molinari, Maria C., additional, Proietti, Giulia, additional, Pepe, Sara, additional, De Falco, Filomena, additional, Mattiello, Veronica, additional, Barabino, Luca, additional, Amici, Roberta, additional, Coscia, Marta, additional, Tedeschi, Alessandra, additional, Girmenia, Corrado, additional, Trentin, Livio, additional, and Baroncelli, Silvia, additional

Published
2023
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28. Polatuzumab‐bendamustine‐rituximab as bridge to CD19‐directed CAR T cells in mantle cell lymphoma refractory to ibrutinib and venetoclax

Author

Perriello, Vincenzo Maria, primary, Falini, Lorenza, additional, Ruggeri, Loredana, additional, Sorcini, Daniele, additional, Ballanti, Stelvio, additional, Flenghi, Leonardo, additional, Baffa, Nicodemo, additional, Covarelli, Piero, additional, Sportoletti, Paolo, additional, Pierini, Antonio, additional, and Falini, Brunangelo, additional

Published
2023
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29. High rate of durable responses with undetectable minimal residual disease with frontline venetoclax and rituximab in young and fit patients with chronic lymphocytic leukemia and an adverse biologic profile: results of the GIMEMA phase II LLC1518 - 'Veritas' study

Author

Mauro, Francesca R, Starza, Irene Della, Messina, Monica, Reda, Gianluigi, Trentin, Livio, Coscia, Marta, Sportoletti, Paolo, Orsucci, Lorella, Arena, Valentina, Casaluci, Gloria Margiotta, Marasca, Roberto, Murru, Roberta, Laurenti, Luca, Ilariucci, Fiorella, Stelitano, Caterina, Mannina, Donato, Massaia, Massimo, Rigolin, Gian Matteo, Scarfò, Lydia, Marchetti, Monia, Levato, Luciano, Tani, Monica, Arcari, Annalisa, Musuraca, Gerardo, Deodato, Marina, Galieni, Piero, Patrizi, Valeria Belsito, Gottardi, Daniela, Liberati, Anna Marina, Giordano, Annamaria, Molinari, Maria Chiara, Pietrasanta, Daniela, Mattiello, Veronica, Visentin, Andrea, Vitale, Candida, Albano, Francesco, Neri, Antonino, De Novi, Lucia Anna, De Propris, Maria Stefania, Nanni, Mauro, Del Giudice, Ilaria, Guarini, Anna, Fazi, Paola, Vignetti, Marco, Piciocchi, Alfonso, Cuneo, Antonio, Foà, Robin, Laurenti, Luca (ORCID:0000-0002-8327-1396), Mauro, Francesca R, Starza, Irene Della, Messina, Monica, Reda, Gianluigi, Trentin, Livio, Coscia, Marta, Sportoletti, Paolo, Orsucci, Lorella, Arena, Valentina, Casaluci, Gloria Margiotta, Marasca, Roberto, Murru, Roberta, Laurenti, Luca, Ilariucci, Fiorella, Stelitano, Caterina, Mannina, Donato, Massaia, Massimo, Rigolin, Gian Matteo, Scarfò, Lydia, Marchetti, Monia, Levato, Luciano, Tani, Monica, Arcari, Annalisa, Musuraca, Gerardo, Deodato, Marina, Galieni, Piero, Patrizi, Valeria Belsito, Gottardi, Daniela, Liberati, Anna Marina, Giordano, Annamaria, Molinari, Maria Chiara, Pietrasanta, Daniela, Mattiello, Veronica, Visentin, Andrea, Vitale, Candida, Albano, Francesco, Neri, Antonino, De Novi, Lucia Anna, De Propris, Maria Stefania, Nanni, Mauro, Del Giudice, Ilaria, Guarini, Anna, Fazi, Paola, Vignetti, Marco, Piciocchi, Alfonso, Cuneo, Antonio, Foà, Robin, and Laurenti, Luca (ORCID:0000-0002-8327-1396)

Abstract

The GIMEMA phase II LLC1518 VERITAS trial investigated the efficacy and safety of frontline, fixed-duration venetoclax and rituximab (VenR) combination in young (≤65 years) and fit patients with chronic lymphocytic leukemia (CLL) and unmutated IGHV and/or TP53 disruption. Treatment consisted of the Ven ramp-up, six-monthly courses of the VenR combination, followed by six monthly courses of Ven single agent. A centralized assessment of measurable minimal residual disease (MRD) was performed on the peripheral blood (PB) and bone marrow (BM) by ASO-PCR at the end of treatment (EOT) and during the follow-up. The primary endpoint was the complete remission (CR) rate at the EOT. Seventy-five patients were enrolled; the median age was 54 years (range 38-65), 96% had unmutated IGHV, 9 (12%) had TP53 disruption, and 4% were IGHV mutated with TP53 disruption. The overall response rate (ORR) at the EOT was 94.7%, with a CR rate of 76%. An undetectable (u) MRD was recorded in 69.3% of patients in the PB and 58.7% in the BM. The 12-month MRD-free survival in the 52 patients with uMRD in the PB at the EOT was 73.1%. After a median follow-up of 20.8 months, no disease progressions were observed. Three patients have died, two due to Covid-19 and 1 to tumor lysis syndrome. The first report of the VERITAS study shows that frontline VenR was associated with a high rate of CRs and durable responses with uMRD in young patients with CLL and unfavorable genetic characteristics.

Published
2023

30. Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY

Author

AbbVie Pharmaceuticals, European Commission, Chatzikonstantinou, Thomas, Scarfò, Lydia, Karakatsoulis, Georgios, Minga, Eva, Chamou, Dimitra, Iacoboni, Gloria, Kotaskova, Jana, Demosthenous, Christos, Smolej, Lukas, Mulligan, Stephen, Alcoceba, Miguel, Kreitman, Robert J., Labrador, Jorge, Lad, Deepesh, Levin, Mark-David, Levy, Ilana, Longval, Thomas, López-García, Alberto, Marquet, Juan, Martín-Rodríguez, Lucía, Maynadié, Marc, Tadmor, Tamar, Maslejova, Stanislava, Mayor-Bastida, Carlota, Mihaljevic, Biljana, Milosevic, Ivana, Mirás, Fátima, Moia, Riccardo, Morawska, Marta, Murru, Roberta, Nath, Uttam Kumar, Navarro-Bailón, Almudena, Tomic, Kristina, Oliveira, Ana C., Olivieri, Jacopo, Oscier, David, Panovska-Stavridis, Irina, Papaioannou, María, Papajík, Tomás, Kubova, Zuzana, Phumphukhieo, Punyarat, Pierie, Cheyenne, Puiggros, Anna, Tse, Eric, Rani, Lata, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Daniel de Deus Santos, Marcos, Schipani, Mattia, Schiwitza, Annett, Shen, Yandong, Simkovic, Martín, Smirnova, Svetlana, Vassilakopoulos, Theodoros, Abdelrahman Soliman, Dina Sameh, Spacek, Martin, Visentin, Andrea, Vitale, Candida, von Tresckow, Julia, Vrachiolias, George, Vukovic, Vojin, Walewska, Renata, Al-Shemari, Salem, Wasik-Szczepanek, Ewa, Xu, Zhenshu, Yagci, Munci, Yañez, Lucrecia, Yassin, Mohamed, Zuchnicka, Jana, Angelopoulou, Maria, Antic, Darko, Biderman, Bella, Catherwood, Mark, Aurran-Schleinitz, Thérèse, Claus, Rainer, Coscia, Marta, Cuneo, Antonio, Demirkan, Fatih, Espinet, Blanca, Gaidano, Gianluca, Kalashnikova, Olga B., Laurenti, Luca, Nikitin, Eugene, Pangalis, Gerassimos A., Bacchiarri, Francesca, Panagiotidis, Panagiotis, Popov, Viola María, Pospisilova, Sarka, Sportoletti, Paolo, Stavroyianni, Niki, Tam, Constantine S., Trentin, Livio, Chatzidimitriou, Anastasia, Bosch, Francesc, Doubek, Michael, Bellido, Mar, Ghia, Paolo, Stamatopoulos, Kostas, Bijou, Fontanet, Calleja, Anne, Medina, Angeles, Khan, Mehreen Ali, Cassin, Ramona, Chatzileontiadou, Sofía, Collado, Rosa, Christian, Amy, Davis, Zadie, Dimou, María, Donaldson, David, Santos, Gimena Dos, Dreta, Bárbara, Efstathopoulou, María, El-Ashwah, Shaimaa, Enrico, Alicia, Fresa, Alberto, Galimberti, Sara, Galitzia, Andrea, García-Serra, Rocío, Gimeno, Eva, González-Gascón y Marín, Isabel, Gozzetti, Alessandro, Guarente, Valerio, Guieze, Romain, Gogia, Ajay, Gupta, Ritu, Harrop, Sean, Hatzimichael, Eleftheria, Herishanu, Yair, Hernández-Rivas, José Ángel, Inchiappa, Luca, Jaksic, Ozren, Janssen, Susanne, Kalicińska, Elżbieta, Kamel, Laribi, Karakus, Volkan, Kater, Arnon P., Kho, Bonnie, Kislova, María, Konstantinou, Eliana, Koren-Michowitz, Maya, Kotsianidis, Ioannis, AbbVie Pharmaceuticals, European Commission, Chatzikonstantinou, Thomas, Scarfò, Lydia, Karakatsoulis, Georgios, Minga, Eva, Chamou, Dimitra, Iacoboni, Gloria, Kotaskova, Jana, Demosthenous, Christos, Smolej, Lukas, Mulligan, Stephen, Alcoceba, Miguel, Kreitman, Robert J., Labrador, Jorge, Lad, Deepesh, Levin, Mark-David, Levy, Ilana, Longval, Thomas, López-García, Alberto, Marquet, Juan, Martín-Rodríguez, Lucía, Maynadié, Marc, Tadmor, Tamar, Maslejova, Stanislava, Mayor-Bastida, Carlota, Mihaljevic, Biljana, Milosevic, Ivana, Mirás, Fátima, Moia, Riccardo, Morawska, Marta, Murru, Roberta, Nath, Uttam Kumar, Navarro-Bailón, Almudena, Tomic, Kristina, Oliveira, Ana C., Olivieri, Jacopo, Oscier, David, Panovska-Stavridis, Irina, Papaioannou, María, Papajík, Tomás, Kubova, Zuzana, Phumphukhieo, Punyarat, Pierie, Cheyenne, Puiggros, Anna, Tse, Eric, Rani, Lata, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Daniel de Deus Santos, Marcos, Schipani, Mattia, Schiwitza, Annett, Shen, Yandong, Simkovic, Martín, Smirnova, Svetlana, Vassilakopoulos, Theodoros, Abdelrahman Soliman, Dina Sameh, Spacek, Martin, Visentin, Andrea, Vitale, Candida, von Tresckow, Julia, Vrachiolias, George, Vukovic, Vojin, Walewska, Renata, Al-Shemari, Salem, Wasik-Szczepanek, Ewa, Xu, Zhenshu, Yagci, Munci, Yañez, Lucrecia, Yassin, Mohamed, Zuchnicka, Jana, Angelopoulou, Maria, Antic, Darko, Biderman, Bella, Catherwood, Mark, Aurran-Schleinitz, Thérèse, Claus, Rainer, Coscia, Marta, Cuneo, Antonio, Demirkan, Fatih, Espinet, Blanca, Gaidano, Gianluca, Kalashnikova, Olga B., Laurenti, Luca, Nikitin, Eugene, Pangalis, Gerassimos A., Bacchiarri, Francesca, Panagiotidis, Panagiotis, Popov, Viola María, Pospisilova, Sarka, Sportoletti, Paolo, Stavroyianni, Niki, Tam, Constantine S., Trentin, Livio, Chatzidimitriou, Anastasia, Bosch, Francesc, Doubek, Michael, Bellido, Mar, Ghia, Paolo, Stamatopoulos, Kostas, Bijou, Fontanet, Calleja, Anne, Medina, Angeles, Khan, Mehreen Ali, Cassin, Ramona, Chatzileontiadou, Sofía, Collado, Rosa, Christian, Amy, Davis, Zadie, Dimou, María, Donaldson, David, Santos, Gimena Dos, Dreta, Bárbara, Efstathopoulou, María, El-Ashwah, Shaimaa, Enrico, Alicia, Fresa, Alberto, Galimberti, Sara, Galitzia, Andrea, García-Serra, Rocío, Gimeno, Eva, González-Gascón y Marín, Isabel, Gozzetti, Alessandro, Guarente, Valerio, Guieze, Romain, Gogia, Ajay, Gupta, Ritu, Harrop, Sean, Hatzimichael, Eleftheria, Herishanu, Yair, Hernández-Rivas, José Ángel, Inchiappa, Luca, Jaksic, Ozren, Janssen, Susanne, Kalicińska, Elżbieta, Kamel, Laribi, Karakus, Volkan, Kater, Arnon P., Kho, Bonnie, Kislova, María, Konstantinou, Eliana, Koren-Michowitz, Maya, and Kotsianidis, Ioannis

Abstract

[Background]: Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work., [Methods]: We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016. Data collection took place between October 2020 and March 2022., [Findings]: In 129,254 years of follow-up after CLL diagnosis, 3513 OMs were diagnosed (27.2 OMs/1000 person-years). The most common hematological OMs were Richter transformation, myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Non-melanoma skin (NMSC) and prostate cancers were the most common solid tumors (STs). The only predictor for MDS and AML development was treatment with fludarabine and cyclophosphamide with/without rituximab (FC ± R) (OR = 3.7; 95% CI = 2.79–4.91; p < 0.001). STs were more frequent in males and patients with unmutated immunoglobulin heavy variable genes (OR = 1.77; 95% CI = 1.49–2.11; p < 0.001/OR = 1.89; 95% CI = 1.6–2.24; p < 0.001). CLL-directed treatment was associated with non-melanoma skin and prostate cancers (OR = 1.8; 95% CI = 1.36–2.41; p < 0.001/OR = 2.11; 95% CI = 1.12–3.97; p = 0.021). In contrast, breast cancers were more frequent in untreated patients (OR = 0.17; 95% CI = 0.08–0.33; p < 0.001). Patients with CLL and an OM had inferior overall survival (OS) than those without. AML and MDS conferred the worst OS (p < 0.001)., [Interpretation]: OMs in CLL impact on OS. Treatment for CLL increased the risk for AML/MDS, prostate cancer, and NMSC. FCR was associated with increased risk for AML/MDS.

Published
2023

31. NOTCH1-mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential.

Author

Barcelos, Estevão Carlos Silva, Rompietti, Chiara, Adamo, Francesco Maria, Dorillo, Erica, De Falco, Filomena, Del Papa, Beatrice, Baldoni, Stefano, Nogarotto, Manuel, Esposito, Angela, Capoccia, Silvia, Geraci, Clelia, Sorcini, Daniele, Stella, Arianna, Arcaleni, Roberta, Tini, Valentina, Valle Errera, Flávia Imbroisi, Rosati, Emanuela, and Sportoletti, Paolo

Subjects
CHRONIC lymphocytic leukemia, CHRONIC leukemia, ENDOPLASMIC reticulum, GENE ontology, UNFOLDED protein response, POLYMERASE chain reaction, B cells
Abstract

Introduction: Constitutive activation of NOTCH1-wild-type (NT1-WT) signaling is associated with poor outcomes in chronic lymphocytic leukemia (CLL), and NOTCH1 mutation (c.7541_7542delCT), which potentiates NOTCH1 signaling, worsens the prognosis. However, the specific mechanisms of NOTCH1 deregulation are still poorly understood. Accumulative evidence mentioned endoplasmic reticulum (ER) stress/unfolded protein response (UPR) as a key targetable pathway in CLL. In this study, we investigated the impact of NOTCH1 deregulation on CLL cell response to ER stress induction, with the aim of identifying new therapeutic opportunities for CLL. Methods: We performed a bioinformatics analysis of NOTCH1-mutated (NT1-M) and NT1-WT CLL to identify differentially expressed genes (DEGs) using the rank product test. Quantitative real-time polymerase chain reaction (qPCR), Western blotting, cytosolic Ca2+, and annexin V/propidium iodide (PI) assay were used to detect curcumin ER stress induction effects. A median-effect equation was used for drug combination tests. The experimental mouse model E -TCL1 was used to evaluate the impact of ER stress exacerbation by curcumin treatment on the progression of leukemic cells and NOTCH1 signaling. Results and discussion: Bioinformatics analysis revealed gene enrichment of the components of the ER stress/UPR pathway in NT1-M compared to those in NT1- WT CLL. Ectopic expression of NOTCH1 mutation upregulated the levels of ER stress response markers in the PGA1 CLL cell line. Primary NT1-M CLL was more sensitive to curcumin as documented by a significant perturbation in Ca2+ homeostasis and higher expression of ER stress/UPR markers compared to NT1-WT cells. It was also accompanied by a significantly higher apoptotic response mediated by C/EBP homologous protein (CHOP) expression, caspase 4 cleavage, and downregulation of NOTCH1 signaling in NT1-M CLL cells. Curcumin potentiated the apoptotic effect of venetoclax in NT1-M CLL cells. In E -TCL1 leukemic mice, the administration of curcumin activated ER stress in splenic B cells ex vivo and significantly reduced the percentage of CD19+/CD5+ cells infiltrating the spleen, liver, and bone marrow (BM). These cellular effects were associated with reduced NOTCH1 activity in leukemic cells and resulted in prolonged survival of curcumin-treated mice. Overall, our results indicate that ER stress induction in NT1-M CLL might represent a new therapeutic opportunity for these high-risk CLL patients and improve the therapeutic effect of drugs currently used in CLL. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Continuous venetoclax in treatment‐naive TP53 disrupted patients with chronic lymphocytic leukemia: A chronic lymphocytic leukemia campus study.

Author

Visentin, Andrea, Mauro, Francesca Romana, Scarfò, Lydia, Gentile, Massimo, Farina, Lucia, Reda, Gianluigi, Ferrarini, Isacco, Proietti, Giulia, Derenzini, Enrico, Cibien, Francesca, Vitale, Candida, Sanna, Alessandro, Pietrasanta, Daniela, Marchetti, Monia, Murru, Roberta, Rigolin, Gian Matteo, Sportoletti, Paolo, Trimarco, Valentina, Cavarretta, Chiara Adele, and Angotzi, Francesco

Published
2023
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33. High rate of durable responses with undetectable minimal residual disease with front-line venetoclax and rituximab in young, fit patients with chronic lymphocytic leukemia and an adverse biological profile: results of the GIMEMA phase II LLC1518 – VERITAS study

Author

Mauro, Francesca R., primary, Starza, Irene Della, additional, Messina, Monica, additional, Reda, Gianluigi, additional, Trentin, Livio, additional, Coscia, Marta, additional, Sportoletti, Paolo, additional, Orsucci, Lorella, additional, Arena, Valentina, additional, Casaluci, Gloria Margiotta, additional, Marasca, Roberto, additional, Murru, Roberta, additional, Laurenti, Luca, additional, Ilariucci, Fiorella, additional, Stelitano, Caterina, additional, Mannina, Donato, additional, Massaia, Massimo, additional, Rigolin, Gian Matteo, additional, Scarfò, Lydia, additional, Marchetti, Monia, additional, Levato, Luciano, additional, Tani, Monica, additional, Arcari, Annalisa, additional, Musuraca, Gerardo, additional, Deodato, Marina, additional, Galieni, Piero, additional, Patrizi, Valeria Belsito, additional, Gottardi, Daniela, additional, Liberati, Anna Marina, additional, Giordano, Annamaria, additional, Molinari, Maria Chiara, additional, Pietrasanta, Daniela, additional, Mattiello, Veronica, additional, Visentin, Andrea, additional, Vitale, Candida, additional, Albano, Francesco, additional, Neri, Antonino, additional, De Novi, Lucia Anna, additional, De Propris, Maria Stefania, additional, Nanni, Mauro, additional, Del Giudice, Ilaria, additional, Guarini, Anna, additional, Fazi, Paola, additional, Vignetti, Marco, additional, Piciocchi, Alfonso, additional, Cuneo, Antonio, additional, and Foà, Robin, additional

Published
2023
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38. Efficacy of front‐line ibrutinib versus fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia: A retrospective multicenter “ Real‐World ” study

Author

Levi, Shai, primary, Bronstein, Yotam, additional, Goldschmidt, Neta, additional, Morabito, Fortunato, additional, Ziv‐Baran, Tomer, additional, Del Poeta, Giovanni, additional, Bairey, Osnat, additional, Del Principe, Maria Ilaria, additional, Fineman, Riva, additional, Mauro, Francesca Romana, additional, Gutwein, Odit, additional, Reda, Gianluigi, additional, Ruchlemer, Rosa, additional, Sportoletti, Paolo, additional, Laurenti, Luca, additional, Shvidel, Lev, additional, Coscia, Marta, additional, Tadmor, Tamar, additional, Varettoni, Marzia, additional, Aviv, Ariel, additional, Murru, Roberta, additional, Braester, Andrei, additional, Chiarenza, Annalisa, additional, Visentin, Andrea, additional, Pietrasanta, Daniela, additional, Loseto, Giacomo, additional, Zucchetto, Antonella, additional, Bomben, Riccardo, additional, Olivieri, Jacopo, additional, Neri, Antonio, additional, Rossi, Davide, additional, Gaidano, Gianluca, additional, Trentin, Livio, additional, Foà, Robin, additional, Cuneo, Antonio, additional, Perry, Chava, additional, Gattei, Valter, additional, Gentile, Massimo, additional, and Herishanu, Yair, additional

Published
2022
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39. Obinutuzumab plus chlorambucil versus ibrutinib in previously untreated chronic lymphocytic leukemia patients without TP53 disruptions: A real-life CLL campus study

Author

Visentin, Andrea, primary, Mauro, Francesca Romana, additional, Catania, Gioachino, additional, Fresa, Alberto, additional, Vitale, Candida, additional, Sanna, Alessandro, additional, Mattiello, Veronica, additional, Cibien, Francesca, additional, Sportoletti, Paolo, additional, Gentile, Massimo, additional, Rigolin, Gian Matteo, additional, Quaglia, Francesca Maria, additional, Murru, Roberta, additional, Gozzetti, Alessandro, additional, Molica, Stefano, additional, Marchetti, Monia, additional, Pravato, Stefano, additional, Angotzi, Francesco, additional, Cellini, Alessandro, additional, Scarfò, Lydia, additional, Reda, Gianluigi, additional, Coscia, Marta, additional, Laurenti, Luca, additional, Ghia, Paolo, additional, Foà, Robin, additional, Cuneo, Antonio, additional, and Trentin, Livio, additional

Published
2022
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40. Real-World Outcome of Treatment with Single-Agent Ibrutinib in Patients with Chronic Lymphocytic Leukemia: Results from the Italian Study Evidence

Author

Molica, Stefano, primary, Scalzulli, Potito Rosario, additional, Scarfò, Lydia, additional, Guarini, Attilio, additional, Murru, Roberta, additional, Sportoletti, Paolo, additional, Frigeri, Ferdinando, additional, Albano, Francesco, additional, Di Renzo, Nicola, additional, Sanna, Alessandro, additional, Innocenti, Idanna, additional, Massaia, Massimo, additional, Coscia, Marta, additional, Pennese, Elsa, additional, Patti, Caterina, additional, Reda, Gianluigi, additional, Tafuri, Agostino, additional, Regazzoni, Giulia, additional, Di Candia, Michele, additional, and Mauro, Francesca Romana, additional

Published
2022
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41. Differences in Clinical Course and Management of Sars-CoV2 Infection in Patients with Chronic Lymphocytic Leukemia between the Sequential Pandemic Phases: An Eric Study

Author

Visentin, Andrea, primary, Scarfò, Lydia, additional, Chatzikonstantinou, Thomas, additional, Kapetanakis, Anargyros, additional, Demosthenous, Christos, additional, Karakatsoulis, Georgios, additional, Andres, Martin, additional, Antic, Darko, additional, Allsup, David, additional, Baile, Mónica, additional, Bron, Dominique, additional, Capasso, Antonella, additional, Catherwood, Mark, additional, Collado, Rosa, additional, Cordoba, Raul, additional, Cuéllar-García, Carolina, additional, Delgado, Julio, additional, Dimou, Maria, additional, Doubek, Michael, additional, De Paoli, Lorenzo, additional, De Paolis, Maria Rosaria, additional, Del Poeta, Giovanni, additional, Efstathopoulou, Maria, additional, Shimaa, El-Ashwah, additional, Enrico, Alicia, additional, Farina, Lucia, additional, Ferrari, Angela, additional, Foglietta, Myriam, additional, Furstenau, Moritz, additional, Garcia-Marco, Jose A., additional, Gentile, Massimo, additional, Gimeno, Eva, additional, Maria, Gomes da Silva, additional, Gutwein, Odit, additional, Hakobyan, Yervand, additional, Herishanu, Yair, additional, Hernandez, jose Angel, additional, Herold, Tobias, additional, Iyengar, Sunil, additional, Itchaki, Gilad, additional, Jaksic, Ozren, additional, Janssens, Ann, additional, Kalashnikova, Olga, additional, Kalicinska, Elzbieta, additional, Kater, Arnon P., additional, Kersting, Sabina, additional, Labrador, Jorge, additional, Lad, Deepesh, additional, Laurenti, Luca, additional, Levin, Mark-David, additional, Lista, Enrico, additional, Malerba, Lara, additional, Marasca, Roberto, additional, Marchetti, Monia, additional, Marquet Palomanes, Juan, additional, Mattsson, Mattias, additional, Mauro, Francesca Romana, additional, Mayor-Bastida, Carlota, additional, Morawska, Marta, additional, Motta, Marina, additional, Munir, Talha, additional, Murru, Roberta, additional, Milosevic, Ivana, additional, Miras Calvo, Fatima, additional, Niemann, Carsten Utoft, additional, Olivieri, Jacopo, additional, Orsucci, Lorella, additional, Papaioannou, Maria, additional, Pavlovsky, Miguel Arturo, additional, Piskunova, Inga S., additional, Pocali, Barbara, additional, Popov, Viola Maria, additional, Quaglia, Francesca Maria, additional, Quaresmini, Giulia, additional, Raa, Doreen te, additional, Reda, Gianluigi, additional, Rigolin, Gian Matteo, additional, Ruchlemer, Rosa, additional, Shrestha, Amit, additional, Šimkovič, Martin, additional, Špaček, Martin, additional, Sportoletti, Paolo, additional, Stanca Ciocan, Oana, additional, Tadmor, Tamar, additional, Vandenberghe, Elisabeth, additional, Varettoni, Marzia, additional, Vitale, Candida, additional, Van Der Spek, Ellen, additional, Van Gelder, Michel, additional, Wasik-Szczepanek, Ewa, additional, Yáñez, Lucrecia, additional, Yassin, Mohamed A, additional, Coscia, Marta, additional, Eichhorst, Barbara, additional, Rambaldi, Alessandro, additional, Stavroyianni, Niki, additional, Trentin, Livio, additional, Stamatopoulos, Kostas, additional, and Ghia, Paolo, additional

Published
2022
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42. Thrombotic and Bleeding Complications in Patients with Chronic Lymphocytic Leukemia and Severe COVID-19: A Study of Eric, the European Research Initiative on CLL

Author

Antic, Darko, primary, Milic, Natasa, additional, Chatzikonstantinou, Thomas, additional, Scarfò, Lydia, additional, Otasevic, Vladimir, additional, Rajovic, Nina, additional, Allsup, David, additional, Cabrero, Alejandro Alonso, additional, Andres, Martin, additional, Baile Gonzales, Monica, additional, Capasso, Antonella, additional, Collado, Rosa, additional, Cordoba, Raul, additional, Cuéllar-García, Carolina, additional, Correa, Juan Gonzalo, additional, De Paoli, Lorenzo, additional, De Paolis, Maria Rosaria, additional, Del Poeta, Giovanni, additional, Dimou, Maria, additional, Doubek, Michael, additional, Efstathopoulou, Maria, additional, El-Ashwah, Shaimaa, additional, Enrico, Alicia, additional, Espinet, Blanca, additional, Farina, Lucia, additional, Ferrari, Angela, additional, Foglietta, Myriam, additional, Lopez-Garcia, Alberto, additional, Garcia-Marco, Jose A., additional, García-Serra, Rocío, additional, Gentile, Massimo, additional, Gimeno, Eva, additional, Gomes da Silva, Maria, additional, Gutwein, Odit, additional, Hakobyan, Yervand, additional, Herishanu, Yair, additional, Hernández-Rivas, José Ángel, additional, Herold, Tobias, additional, Itchaki, Gilad, additional, Jaksic, Ozren, additional, Janssens, Ann, additional, Kalashnikova, Оlga B., additional, Kalicińska, Elżbieta, additional, Kater, Arnon P., additional, Kersting, Sabina, additional, Koren-Michowitz, Maya, additional, Gomez, Jorge Labrador, additional, Lad, Deepesh, additional, Laurenti, Luca, additional, Fresa, Alberto, additional, Levin, Mark-David, additional, Mayor Bastida, Carlota, additional, Malerba, Lara, additional, Marasca, Roberto, additional, Marchetti, Monia, additional, Marquet, Juan, additional, Mihaljevic, Biljana, additional, Milosevic, Ivana, additional, Mirás, Fatima, additional, Morawska, Marta, additional, Motta, Marina, additional, Munir, Talha, additional, Murru, Roberta, additional, Nunes, Raquel, additional, Olivieri, Jacopo, additional, Pavlovsky, Miguel Arturo, additional, Piskunova, Inga S., additional, Popov, Viola Maria, additional, Quaglia, Francesca Maria, additional, Quaresmini, Giulia, additional, Reda, Gianluigi, additional, Rigolin, Gian Matteo, additional, Shrestha, Amit, additional, Šimkovič, Martin, additional, Smirnova, Svetlana, additional, Špaček, Martin, additional, Sportoletti, Paolo, additional, Stanca, Oana, additional, Stavroyianni, Niki, additional, Te Raa, Doreen, additional, Tomic, Kristina, additional, Tonino, Sanne, additional, Trentin, Livio, additional, Van Der Spek, Ellen, additional, van Gelder, Michel, additional, Varettoni, Marzia, additional, Visentin, Andrea, additional, Vitale, Candida, additional, Vukovic, Vojin, additional, Wasik-Szczepanek, Ewa, additional, Wróbel, Tomasz, additional, Yanez San Segundo, Lucrecia, additional, Yassin, Mohamed A, additional, Coscia, Marta, additional, Rambaldi, Alessandro, additional, Montserrat, Emili, additional, Foà, Robin, additional, Cuneo, Antonio, additional, Carrier, Marc, additional, Ghia, Paolo, additional, and Stamatopoulos, Kostas, additional

Published
2022
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43. Continuous Venetoclax in Previously Untreated Patients with Chronic Lymphocytic Leukemia and TP53 Abnormalities. a Study of the Italian Campus CLL

Author

Visentin, Andrea, primary, Mauro, Francesca, additional, Scarfò, Lydia, additional, Gentile, Massimo, additional, Farina, Lucia, additional, Reda, Gianluigi, additional, Ferrarini, Isacco, additional, Proietti, Giulia, additional, Derenzini, Enrico, additional, Cibien, Francesca, additional, Vitale, Candida, additional, Sanna, Alessandro, additional, Catania, Gioachino, additional, Marchetti, Monia, additional, Murru, Roberta, additional, Rigolin, Gian Matteo, additional, Sportoletti, Paolo, additional, Laurenti, Luca, additional, Molica, Stefano, additional, Coscia, Marta, additional, Ghia, Paolo, additional, Foa, Robin, additional, Cuneo, Antonio, additional, and Trentin, Livio, additional

Published
2022
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44. Choice of Tyrosine Kinase Inhibitor and Early Events during the First Year of Therapy in Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia (CML) Patients with Concomitant Diabetes: A "Campus CML" Study

Author

Capodanno, Isabella, primary, Tiribelli, Mario, additional, Miggiano, Maria Cristina, additional, Bucelli, Cristina, additional, Cavazzini, Francesco, additional, Leonetti Crescenzi, Sabrina, additional, Russo, Sabina, additional, Scalzulli, Emilia, additional, Bernardelli, Andrea, additional, Luciano, Luigiana, additional, Mulas, Olga, additional, Loglisci, Giuseppina, additional, Elena, Chiara, additional, Pizzano, Umberto, additional, Attolico, Immacolata, additional, Binotto, Gianni, additional, Crisà, Elena, additional, Sportoletti, Paolo, additional, Di Veroli, Ambra, additional, Scortechini, Anna Rita, additional, Leporace, Annapaola, additional, Basile, Maria, additional, Crugnola, Monica, additional, Stagno, Fabio, additional, Murgano, Pamela, additional, Rapezzi, Davide, additional, Luzi, Debora, additional, Iurlo, Alessandra, additional, Bocchia, Monica, additional, Fava, Carmen, additional, Malato, Alessandra, additional, Galimberti, Sara, additional, Vincelli, Iolanda Donatella, additional, Trawinska, Malgorzata Monika, additional, Pizzuti, Michele, additional, Caocci, Giovanni, additional, Bonifacio, Massimiliano, additional, Saglio, Giuseppe, additional, Specchia, Giorgina, additional, Breccia, Massimo, additional, and Latagliata, Roberto, additional

Published
2022
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45. Treatment-Free Remission Outcome in Patients with Chronic Myeloid Leukemia in Chronic Phase Following One Year of Nilotinib De-Escalation: 96-Week Update of Dante Study

Author

Stagno, Fabio, primary, Abruzzese, Elisabetta, additional, Iurlo, Alessandra, additional, Pane, Fabrizio, additional, Attolico, Imma, additional, Sportoletti, Paolo, additional, Pregno, Patrizia, additional, Galimberti, Sara, additional, Scappini, Barbara, additional, Miglino, Maurizio, additional, Siragusa, Sergio, additional, Capodanno, Isabella, additional, Valsecchi, Diletta, additional, Nardozza, Aurelio Pio, additional, Coco, Paola, additional, Rosti, Gianantonio, additional, Saglio, Giuseppe, additional, and Breccia, Massimo, additional

Published
2022
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46. How Age, Comorbidities and Concomitant Medications Influence Ibrutinib Management and Survival in Waldenstrom Macroglobulinemia

Author

Frustaci, Annamaria, primary, Piazza, Francesco, additional, Ferrero, Simone, additional, Reda, Gianluigi, additional, Rizzi, Rita, additional, Orsucci, Lorella, additional, Ferrarini, Isacco, additional, Deodato, Marina, additional, Laurenti, Luca, additional, Puccini, Benedetta, additional, Baratè, Claudia, additional, Varettoni, Marzia, additional, Merli, Michele, additional, Cencini, Emanuele, additional, Greco, Antonino, additional, Gini, Guido, additional, Ferrari, Angela, additional, Borella, Chiara, additional, Lista, Enrico, additional, Gentile, Massimo, additional, Murru, Roberta, additional, Motta, Marina, additional, Rezzonico, Francesca, additional, Tani, Monica, additional, Sportoletti, Paolo, additional, Zamprogna, Giulia, additional, Torri, Valter, additional, Cairoli, Roberto, additional, and Tedeschi, Alessandra, additional

Published
2022
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47. Dosing Pattern of Ruxolitinib (RUX) in Patients with Myelofibrosis (MF) in Italy: Results from a Prospective Observational Study (ROMEI)

Author

Breccia, Massimo, primary, Guglielmelli, Paola, additional, Mendicino, Francesco, additional, Malato, Alessandra, additional, Palumbo, Giuseppe A., additional, Selleri, Carmine, additional, Cilloni, Daniela, additional, Mazza, Patrizio, additional, Siragusa, Sergio, additional, Abruzzese, Elisabetta, additional, Martelli, Maurizio, additional, Benevolo, Giulia, additional, Rinaldi, Erminia, additional, Crugnola, Monica, additional, Rupoli, Serena, additional, Pavone, Vincenzo, additional, Bonifacio, Massimiliano, additional, Pane, Fabrizio, additional, Carli, Giuseppe, additional, Langella, Maria, additional, Bruno Ventre, Marta, additional, Elli, Elena Maria, additional, Impera, Stefana, additional, Liberati, Anna Marina, additional, Di Renzo, Nicola, additional, Martino, Bruno, additional, Sportoletti, Paolo, additional, Tiribelli, Mario, additional, Binotto, Gianni, additional, Annunziata, Mario, additional, Di Ianni, Mauro, additional, La Nasa, Giorgio, additional, Falcone, Antonietta Pia, additional, Leanza, Rossana, additional, Volpe, Antonio, additional, Gherlinzoni, Filippo, additional, De Stefano, Valerio, additional, Vallisa, Daniele, additional, Leonetti Crescenzi, Sabrina, additional, Cavazzini, Francesco, additional, Ricco, Alessandra, additional, Barberio, Carmela, additional, Misto, Alessandra, additional, Passamonti, Francesco, additional, and Palandri, Francesca, additional

Published
2022
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48. Relative dose intensity of obinutuzumab-chlorambucil in chronic lymphocytic leukemia: a multicenter Italian study

Author

Fresa, Alberto, primary, Autore, Francesco, additional, Piciocchi, Alfonso, additional, Catania, Gioacchino, additional, Visentin, Andrea, additional, Tomasso, Annamaria, additional, Moretti, Marina, additional, Vitale, Candida, additional, Chiarenza, Annalisa, additional, Morelli, Francesca, additional, Sportoletti, Paolo, additional, Marasca, Roberto, additional, Sapienza, Giuseppe, additional, Cuccaro, Annarosa, additional, Murru, Roberta, additional, Sanna, Alessandro, additional, Patti, Caterina, additional, Angeletti, Ilaria, additional, Coscia, Marta, additional, Trentin, Livio, additional, Pietrasanta, Daniela, additional, Innocenti, Idanna, additional, and Laurenti, Luca, additional

Published
2022
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50. Differences in Clinical Course and Management of Sars-CoV2 Infection in Patients with Chronic Lymphocytic Leukemia between the Sequential Pandemic Phases: An Eric Study

Author

Visentin, Andrea, Scarfo, Lydia, Chatzikonstantinou, Thomas, Kapetanakis, Anargyros, Demosthenous, Christos, Karakatsoulis, Georgios, Andres, Martin, Antic, Darko, Allsup, David, Baile, Monica, Bron, Dominique, Capasso, Antonella, Catherwood, Mark, Collado, Rosa, Cordoba, Raul, Cuellar-Garcia, Carolina, Delgado, Julio, Dimou, Maria, Doubek, Michael, De Paoli, Lorenzo, De Paolis, Maria Rosaria, Del Poeta, Giovanni, Efstathopoulou, Maria, Shimaa, El-Ashwah, Enrico, Alicia, Farina, Lucia, Ferrari, Angela, Foglietta, Myriam, Furstenau, Moritz, Garcia-Marco, Jose A., Gentile, Massimo, Gimeno, Eva, Maria, Gomes da Silva, Gutwein, Odit, Hakobyan, Yervand, Herishanu, Yair, Hernandez, Jose Angel, Herold, Tobias, Iyengar, Sunil, Itchaki, Gilad, Jaksic, Ozren, Janssens, Ann, Kalashnikova, Olga, Kalicinska, Elzbieta, Kater, Arnon P., Kersting, Sabina, Labrador, Jorge, Lad, Deepesh, Laurenti, Luca, Levin, Mark-David, Lista, Enrico, Malerba, Lara, Marasca, Roberto, Marchetti, Monia, Palomanes, Juan Marquet, Mattsson, Mattias, Mauro, Francesca Romana, Mayor-Bastida, Carlota, Morawska, Marta, Motta, Marina, Munir, Talha, Murru, Roberta, Milosevic, Ivana, Calvo, Fatima Miras, Niemann, Carsten Utoft, Olivieri, Jacopo, Orsucci, Lorella, Papaioannou, Maria, Pavlovsky, Miguel Arturo, Piskunova, Inga S., Pocali, Barbara, Popov, Viola Maria, Quaglia, Francesca Maria, Quaresmini, Giulia, te Raa, Doreen, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Shrestha, Amit, Simkovic, Martin, Spacek, Martin, Sportoletti, Paolo, Ciocan, Oana Stanca, Tadmor, Tamar, Vandenberghe, Elisabeth, Varettoni, Marzia, Vitale, Candida, Van der Spek, Ellen, Van Gelder, Michel, Wasik-Szczepanek, Ewa, Yanez, Lucrecia, Yassin, Mohamed A., Coscia, Marta, Eichhorst, Barbara, Rambaldi, Alessandro, Stavroyianni, Niki, Trentin, Livio, Stamatopoulos, Kostas, Ghia, Paolo, Visentin, Andrea, Scarfo, Lydia, Chatzikonstantinou, Thomas, Kapetanakis, Anargyros, Demosthenous, Christos, Karakatsoulis, Georgios, Andres, Martin, Antic, Darko, Allsup, David, Baile, Monica, Bron, Dominique, Capasso, Antonella, Catherwood, Mark, Collado, Rosa, Cordoba, Raul, Cuellar-Garcia, Carolina, Delgado, Julio, Dimou, Maria, Doubek, Michael, De Paoli, Lorenzo, De Paolis, Maria Rosaria, Del Poeta, Giovanni, Efstathopoulou, Maria, Shimaa, El-Ashwah, Enrico, Alicia, Farina, Lucia, Ferrari, Angela, Foglietta, Myriam, Furstenau, Moritz, Garcia-Marco, Jose A., Gentile, Massimo, Gimeno, Eva, Maria, Gomes da Silva, Gutwein, Odit, Hakobyan, Yervand, Herishanu, Yair, Hernandez, Jose Angel, Herold, Tobias, Iyengar, Sunil, Itchaki, Gilad, Jaksic, Ozren, Janssens, Ann, Kalashnikova, Olga, Kalicinska, Elzbieta, Kater, Arnon P., Kersting, Sabina, Labrador, Jorge, Lad, Deepesh, Laurenti, Luca, Levin, Mark-David, Lista, Enrico, Malerba, Lara, Marasca, Roberto, Marchetti, Monia, Palomanes, Juan Marquet, Mattsson, Mattias, Mauro, Francesca Romana, Mayor-Bastida, Carlota, Morawska, Marta, Motta, Marina, Munir, Talha, Murru, Roberta, Milosevic, Ivana, Calvo, Fatima Miras, Niemann, Carsten Utoft, Olivieri, Jacopo, Orsucci, Lorella, Papaioannou, Maria, Pavlovsky, Miguel Arturo, Piskunova, Inga S., Pocali, Barbara, Popov, Viola Maria, Quaglia, Francesca Maria, Quaresmini, Giulia, te Raa, Doreen, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Shrestha, Amit, Simkovic, Martin, Spacek, Martin, Sportoletti, Paolo, Ciocan, Oana Stanca, Tadmor, Tamar, Vandenberghe, Elisabeth, Varettoni, Marzia, Vitale, Candida, Van der Spek, Ellen, Van Gelder, Michel, Wasik-Szczepanek, Ewa, Yanez, Lucrecia, Yassin, Mohamed A., Coscia, Marta, Eichhorst, Barbara, Rambaldi, Alessandro, Stavroyianni, Niki, Trentin, Livio, Stamatopoulos, Kostas, and Ghia, Paolo

Published
2022

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