1. Notch signaling: Its essential roles in bone and craniofacial development
- Author
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Changchun Niu, Jason Strelzow, Na Ni, Di Wu, Kevin H. Qin, Hao Hao Wang, Alonzo Jones, Tong-Chuan He, Mostafa H. El Dafrawy, Junyi Liao, Huaxiu Luo, Russell R. Reid, Kelly Hynes, Jing Zhang, Xiaoxing Wu, Michael J. Lee, Zongyue Zeng, Deyao Shi, Yukun Mao, Linjuan Huang, Mikhail Pakvasa, Pranav N. Haravu, Meng Meng Zhang, Meng. T. Wu, Qing Liu, Michael Boachie-Mensah, Elam Coalson, Kai Fu, Jennifer Moriatis Wolf, Aravind Athiviraham, Sherwin S. W. Ho, Fang He, Yongtao Zhang, and Xia Zhao
- Subjects
0301 basic medicine ,Spondylocostal dysosotosis ,Notch ,lcsh:QH426-470 ,Notch signaling pathway ,Review Article ,Biology ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Osteogenesis ,Craniosynostosis ,medicine ,Craniofacial skeleton ,Craniofacial ,Bone ,Molecular Biology ,Genetics (clinical) ,Oncogenesis ,lcsh:R5-920 ,Cell Biology ,Alagille syndrome ,lcsh:Genetics ,Skull ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Signal transduction ,lcsh:Medicine (General) ,Neuroscience ,Craniofacial development - Abstract
Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future.
- Published
- 2020