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7. Role of the HIF-1α/BNIP3 Signaling Pathway in Recurrent Hepatocellular Carcinoma and the Mechanism of Traditional Chinese Medicine

Author

Liu,Sizhe, Kang,Le, Song,Yagang, and Miao,Mingsan

Subjects
Journal of Hepatocellular Carcinoma
Abstract

Sizhe Liu, Le Kang, Yagang Song, Mingsan Miao School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, People’s Republic of ChinaCorrespondence: Mingsan Miao, School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, People’s Republic of China, Tel/Fax +86-371-65962546, Email miaomingsan@163.comAbstract: Recurrence of hepatocellular carcinoma (HCC) negatively affects the quality of life of patients and leads to death. Studies have shown that recurrent hepatocellular carcinoma (RHCC) is closely related to tissue hypoxia and autophagy. It has been shown that hypoxia-inducible factor-1α (HIF-1α) and its downstream factor BCL-2 19 kDa-interacting protein 3 (BNIP3) promote cellular autophagy under hypoxic conditions, resulting in metastasis and RHCC. In this article, the molecular structures of HIF-1α and BNIP3 are described, and the significance of the HIF-1α/BNIP3 signaling pathway in RHCC is explained. Moreover, the role and mechanism of traditional Chinese medicine (TCM) in treating RHCC by modulating the HIF-1α/BNIP3 signaling pathway is discussed. Studies have shown that the HIF-1α/BNIP3 signaling pathway is a potential target of TCM in the treatment of RHCC. The mechanism of the HIF-1α/BNIP3 signaling pathway in RHCC and the progress achieved in TCM research on targeting and regulating this pathway are also reviewed in this article. The objective was to provide a theoretical basis for the prevention and treatment of RHCC, as well as further drug development.Keywords: recurrent hepatocellular carcinoma, HIF-1α/BNIP3 signaling pathway, traditional Chinese medicine, hypoxia, autophagy

Published
2023

8. Radix Salvia miltiorrhiza Ameliorates Burn Injuries by Reducing Inflammation and Promoting Wound Healing

Author

Tian,Shuo, Guo,Lin, Song,Yagang, Yang,Huiyan, Wang,Jia, Qiao,Jingyi, Wu,Xiangxiang, Bai,Ming, Miao,Mingsan, Tian,Shuo, Guo,Lin, Song,Yagang, Yang,Huiyan, Wang,Jia, Qiao,Jingyi, Wu,Xiangxiang, Bai,Ming, and Miao,Mingsan

Abstract

Shuo Tian,1,2 Lin Guo,3 Yagang Song,1,2 Huiyan Yang,1 Jia Wang,3 Jingyi Qiao,1,2 Xiangxiang Wu,1,2 Ming Bai,1,2 Mingsan Miao1,2 1Academy of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 2Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 3Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of ChinaCorrespondence: Mingsan Miao, Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China, Tel/Fax +86 371 65962546, Email miaomingsan@hactcm.edu.cnPurpose: Radix Salvia miltiorrhiza (RSM), a commonly used medicinal plant, has been reported to have anti-inflammatory effects, but relevant studies on burn injuries are lacking. We investigated the anti-inflammation and wound healing (WH) effects of an aqueous extract of RSM on a burn model in rats.Methods: The effects of RSM were studied by heat-induced burns in rats, treatment with vehicle, Jinwanhong ointment, and RSM (1.5 or 0.75 g/mL). Indicators of burn tissue (BT) were photographed by digital machines and analyzed. The microcirculation in BT was detected by scattered full-frame real-time imaging. Levels of inflammatory mediators and growth factors were measured by enzyme-linked immunosorbent assay (ELISA) and immunohistochemical staining. Local pathologic changes in BT were observed by hematoxylin-and-eosin (HE) staining. Ultrahigh pressure liquid chromatography–linear ion trap–Orbitrap mass spectrometry (UHPLC–LTQ–Orbitrap-MS) was used to explore the absorption of RSM in local skin, subcutaneous tissue, muscle tissue, serum, liver tissue, and kidney tissue.Results: RSM treatment could reduce the w

Published
2023

11. The Effects of Okra Consumption on Glycemic Parameters and Lipid Profile in Adults: A Systematic Review and Meta‐Analysis.

Author

Zhang, Xiaolei, Miao, Jinxin, Song, Yagang, and Miao, Mingsan

Abstract

ABSTRACT The clinical research findings on the effects of okra consumption on blood glucose and lipids are inconsistent. In this study, we aimed to explore the impact of okra consumption on glycemic parameters and lipid profile in adults, including homeostatic model assessment for insulin resistance (HOMA‐IR), glycosylated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C). To find relevant randomized controlled trials (RCTs), we systemically searched EMBASE, Web of Science, PubMed, Cochrane Library, and Scopus until April 2024. According to the inclusion and exclusion criteria, eight studies involving 521 participants were ultimately included in the present study. Compared to placebo, okra consumption remarkably decreased FBG (WMD: −32.56 mg/dL; 95% CI: −48.83, −16.28; p < 0.001; I2 = 84.7%), HbA1c (WMD: −0.48%; 95% CI: −0.81, −0.16; p = 0.004; I2 = 5.5%), TG (WMD: −13.16 mg/dL; 95% CI: −23.54, −2.77; p = 0.013; I2 = 0.0%), and TC (WMD: −9.70 mg/dL; 95% CI: −14.95, −4.46; p < 0.001; I2 = 38.3%) in adults. However, okra showed no notable impact on HOMA‐IR, HDL‐C, and LDL‐C. Okra consumption has an improving effect on adult FBG, HbA1c, TG, and TC levels. More large‐scale RCT studies are necessary to validate the beneficial effects of okra on adults due to the limited number of included RCTs.Trial Registration: PROSPERO: CRD42024540121 [ABSTRACT FROM AUTHOR]

Published
2024
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