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198 results on '"Sokoll, Lori J."'

1. Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex

Author

Hemken, Philip M., Qin, Xuzhen, Sokoll, Lori J., Jackson, Laurel, Feng, Fan, Li, Peng, Gawel, Susan H., Tu, Bailin, Lin, Zhihong, Hartnett, James, Hawksworth, David, Tieman, Bryan C., Yoshimura, Toru, Kinukawa, Hideki, Ning, Shaohua, Liu, Enfu, Meng, Fanju, Chen, Fei, Miao, Juru, Mi, Xuan, Tong, Xin, Chan, Daniel W., and Davis, Gerard J.

Published
2023
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3. The Prostate Health Index Selectively Identifies Clinically Significant Prostate Cancer

Author

Loeb, Stacy, Sanda, Martin G, Broyles, Dennis L, Shin, Sanghyuk S, Bangma, Chris H, Wei, John T, Partin, Alan W, Klee, George G, Slawin, Kevin M, Marks, Leonard S, van Schaik, Ron HN, Chan, Daniel W, Sokoll, Lori J, Cruz, Amabelle B, Mizrahi, Isaac A, and Catalona, William J

Subjects
Cancer, Clinical Research, Prostate Cancer, Aging, Urologic Diseases, Good Health and Well Being, Aged, Aged, 80 and over, Health Status Indicators, Humans, Male, Middle Aged, Prospective Studies, Prostate-Specific Antigen, Prostatic Neoplasms, Protein Precursors, biological markers, prostatic neoplasms, early detection of cancer
Abstract

PurposeThe Prostate Health Index (phi) is a new test combining total, free and [-2]proPSA into a single score. It was recently approved by the FDA and is now commercially available in the U.S., Europe and Australia. We investigate whether phi improves specificity for detecting clinically significant prostate cancer and can help reduce prostate cancer over diagnosis.Materials and methodsFrom a multicenter prospective trial we identified 658 men age 50 years or older with prostate specific antigen 4 to 10 ng/ml and normal digital rectal examination who underwent prostate biopsy. In this population we compared the performance of prostate specific antigen, % free prostate specific antigen, [-2]proPSA and phi to predict biopsy results and, specifically, the presence of clinically significant prostate cancer using multiple criteria.ResultsThe Prostate Health Index was significantly higher in men with Gleason 7 or greater and "Epstein significant" cancer. On receiver operating characteristic analysis phi had the highest AUC for overall prostate cancer (AUCs phi 0.708, percent free prostate specific antigen 0.648, [-2]proPSA 0.550 and prostate specific antigen 0.516), Gleason 7 or greater (AUCs phi 0.707, percent free prostate specific antigen 0.661, [-2]proPSA 0.558, prostate specific antigen 0.551) and significant prostate cancer (AUCs phi 0.698, percent free prostate specific antigen 0.654, [-2]proPSA 0.550, prostate specific antigen 0.549). At the 90% sensitivity cut point for phi (a score less than 28.6) 30.1% of patients could have been spared an unnecessary biopsy for benign disease or insignificant prostate cancer compared to 21.7% using percent free prostate specific antigen.ConclusionsThe new phi test outperforms its individual components of total, free and [-2]proPSA for the identification of clinically significant prostate cancer. Phi may be useful as part of a multivariable approach to reduce prostate biopsies and over diagnosis.

Published
2015

10. Additional file 1 of VCAM-1 complements CA-125 in detecting recurrent ovarian cancer

Author

Song, Jin, Sokoll, Lori J., Zhang, Zhen, and Chan, Daniel W.

Abstract

Additional file 1: Figure S1. Calibration curves of the 8-plex immunoassay. A-H, calibration curves of B7-H3, IL-6, PLA2G7, Tie-1, GDF-15, IL-6 R alpha, SDC1, and VCAM-1 in the 8-plex immunoassay generated using the 5 parameter (5PL) logistic regression model. A.U., arbitrary units. Table S1. Analytical performance of the 8-plex immunoassay. Table S2. Statistics of individual biomarkers of the 8-plex assay in healthy controls, primary, and recurrent ovarian cancer patients.

Published
2023
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13. Proteogenomic characterization of pancreatic ductal adenocarcinoma

Author

Cao, Liwei, primary, Huang, Chen, additional, Cui Zhou, Daniel, additional, Hu, Yingwei, additional, Lih, T. Mamie, additional, Savage, Sara R., additional, Krug, Karsten, additional, Clark, David J., additional, Schnaubelt, Michael, additional, Chen, Lijun, additional, da Veiga Leprevost, Felipe, additional, Eguez, Rodrigo Vargas, additional, Yang, Weiming, additional, Pan, Jianbo, additional, Wen, Bo, additional, Dou, Yongchao, additional, Jiang, Wen, additional, Liao, Yuxing, additional, Shi, Zhiao, additional, Terekhanova, Nadezhda V., additional, Cao, Song, additional, Lu, Rita Jui-Hsien, additional, Li, Yize, additional, Liu, Ruiyang, additional, Zhu, Houxiang, additional, Ronning, Peter, additional, Wu, Yige, additional, Wyczalkowski, Matthew A., additional, Easwaran, Hariharan, additional, Danilova, Ludmila, additional, Mer, Arvind Singh, additional, Yoo, Seungyeul, additional, Wang, Joshua M., additional, Liu, Wenke, additional, Haibe-Kains, Benjamin, additional, Thiagarajan, Mathangi, additional, Jewell, Scott D., additional, Hostetter, Galen, additional, Newton, Chelsea J., additional, Li, Qing Kay, additional, Roehrl, Michael H., additional, Fenyö, David, additional, Wang, Pei, additional, Nesvizhskii, Alexey I., additional, Mani, D.R., additional, Omenn, Gilbert S., additional, Boja, Emily S., additional, Mesri, Mehdi, additional, Robles, Ana I., additional, Rodriguez, Henry, additional, Bathe, Oliver F., additional, Chan, Daniel W., additional, Hruban, Ralph H., additional, Ding, Li, additional, Zhang, Bing, additional, Zhang, Hui, additional, Amin, Mitual, additional, An, Eunkyung, additional, Ayad, Christina, additional, Bauer, Thomas, additional, Birger, Chet, additional, Birrer, Michael J., additional, Boca, Simina M., additional, Bocik, William, additional, Borucki, Melissa, additional, Cai, Shuang, additional, Carr, Steven A., additional, Cerda, Sandra, additional, Chen, Huan, additional, Chen, Steven, additional, Chesla, David, additional, Chinnaiyan, Arul M., additional, Colaprico, Antonio, additional, Cottingham, Sandra, additional, Derejska, Magdalena, additional, Dhanasekaran, Saravana M., additional, Domagalski, Marcin J., additional, Druker, Brian J., additional, Duffy, Elizabeth, additional, Dyer, Maureen A., additional, Edwards, Nathan J., additional, Ellis, Matthew J., additional, Eschbacher, Jennifer, additional, Francis, Alicia, additional, Francis, Jesse, additional, Gabriel, Stacey, additional, Gabrovski, Nikolay, additional, Gardner, Johanna, additional, Getz, Gad, additional, Gillette, Michael A., additional, Goldthwaite, Charles A., additional, Grady, Pamela, additional, Guo, Shuai, additional, Hariharan, Pushpa, additional, Hiltke, Tara, additional, Hindenach, Barbara, additional, Hoadley, Katherine A., additional, Huang, Jasmine, additional, Jones, Corbin D., additional, Ketchum, Karen A., additional, Kinsinger, Christopher R., additional, Koziak, Jennifer M., additional, Kusnierz, Katarzyna, additional, Liu, Tao, additional, Long, Jiang, additional, Mallery, David, additional, Mareedu, Sailaja, additional, Matteotti, Ronald, additional, Maunganidze, Nicollette, additional, McGarvey, Peter B., additional, Minoo, Parham, additional, Paklina, Oxana V., additional, Paulovich, Amanda G., additional, Payne, Samuel H., additional, Potapova, Olga, additional, Pruetz, Barbara, additional, Qi, Liqun, additional, Roche, Nancy, additional, Rodland, Karin D., additional, Rohrer, Daniel C., additional, Schadt, Eric E., additional, Shabunin, Alexey V., additional, Shelton, Troy, additional, Shutack, Yvonne, additional, Singh, Shilpi, additional, Smith, Michael, additional, Smith, Richard D., additional, Sokoll, Lori J., additional, Suh, James, additional, Thangudu, Ratna R., additional, Tsang, Shirley X., additional, Um, Ki Sung, additional, Valley, Dana R., additional, Vatanian, Negin, additional, Wang, Wenyi, additional, Wilson, George D., additional, Wiznerowicz, Maciej, additional, Zhang, Zhen, additional, and Zhao, Grace, additional

Published
2021
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18. Proteogenomic and metabolomic characterization of human glioblastoma

Author

Wang, Liang-Bo, primary, Karpova, Alla, additional, Gritsenko, Marina A., additional, Kyle, Jennifer E., additional, Cao, Song, additional, Li, Yize, additional, Rykunov, Dmitry, additional, Colaprico, Antonio, additional, Rothstein, Joseph H., additional, Hong, Runyu, additional, Stathias, Vasileios, additional, Cornwell, MacIntosh, additional, Petralia, Francesca, additional, Wu, Yige, additional, Reva, Boris, additional, Krug, Karsten, additional, Pugliese, Pietro, additional, Kawaler, Emily, additional, Olsen, Lindsey K., additional, Liang, Wen-Wei, additional, Song, Xiaoyu, additional, Dou, Yongchao, additional, Wendl, Michael C., additional, Caravan, Wagma, additional, Liu, Wenke, additional, Cui Zhou, Daniel, additional, Ji, Jiayi, additional, Tsai, Chia-Feng, additional, Petyuk, Vladislav A., additional, Moon, Jamie, additional, Ma, Weiping, additional, Chu, Rosalie K., additional, Weitz, Karl K., additional, Moore, Ronald J., additional, Monroe, Matthew E., additional, Zhao, Rui, additional, Yang, Xiaolu, additional, Yoo, Seungyeul, additional, Krek, Azra, additional, Demopoulos, Alexis, additional, Zhu, Houxiang, additional, Wyczalkowski, Matthew A., additional, McMichael, Joshua F., additional, Henderson, Brittany L., additional, Lindgren, Caleb M., additional, Boekweg, Hannah, additional, Lu, Shuangjia, additional, Baral, Jessika, additional, Yao, Lijun, additional, Stratton, Kelly G., additional, Bramer, Lisa M., additional, Zink, Erika, additional, Couvillion, Sneha P., additional, Bloodsworth, Kent J., additional, Satpathy, Shankha, additional, Sieh, Weiva, additional, Boca, Simina M., additional, Schürer, Stephan, additional, Chen, Feng, additional, Wiznerowicz, Maciej, additional, Ketchum, Karen A., additional, Boja, Emily S., additional, Kinsinger, Christopher R., additional, Robles, Ana I., additional, Hiltke, Tara, additional, Thiagarajan, Mathangi, additional, Nesvizhskii, Alexey I., additional, Zhang, Bing, additional, Mani, D.R., additional, Ceccarelli, Michele, additional, Chen, Xi S., additional, Cottingham, Sandra L., additional, Li, Qing Kay, additional, Kim, Albert H., additional, Fenyö, David, additional, Ruggles, Kelly V., additional, Rodriguez, Henry, additional, Mesri, Mehdi, additional, Payne, Samuel H., additional, Resnick, Adam C., additional, Wang, Pei, additional, Smith, Richard D., additional, Iavarone, Antonio, additional, Chheda, Milan G., additional, Barnholtz-Sloan, Jill S., additional, Rodland, Karin D., additional, Liu, Tao, additional, Ding, Li, additional, Agarwal, Anupriya, additional, Amin, Mitual, additional, An, Eunkyung, additional, Anderson, Matthew L., additional, Andrews, David W., additional, Bauer, Thomas, additional, Birger, Chet, additional, Birrer, Michael J., additional, Blumenberg, Lili, additional, Bocik, William E., additional, Borate, Uma, additional, Borucki, Melissa, additional, Burke, Meghan C., additional, Cai, Shuang, additional, Calinawan, Anna P., additional, Carr, Steven A., additional, Cerda, Sandra, additional, Chan, Daniel W., additional, Charamut, Alyssa, additional, Chen, Lin S., additional, Chesla, David, additional, Chinnaiyan, Arul M., additional, Chowdhury, Shrabanti, additional, Cieślik, Marcin P., additional, Clark, David J., additional, Culpepper, Houston, additional, Czernicki, Tomasz, additional, D'Angelo, Fulvio, additional, Day, Jacob, additional, De Young, Stephanie, additional, Demir, Emek, additional, Dhanasekaran, Saravana Mohan, additional, Dhir, Rajiv, additional, Domagalski, Marcin J., additional, Druker, Brian, additional, Duffy, Elizabeth, additional, Dyer, Maureen, additional, Edwards, Nathan J., additional, Edwards, Robert, additional, Elburn, Kimberly, additional, Ellis, Matthew J., additional, Eschbacher, Jennifer, additional, Francis, Alicia, additional, Gabriel, Stacey, additional, Gabrovski, Nikolay, additional, Garofano, Luciano, additional, Getz, Gad, additional, Gillette, Michael A., additional, Godwin, Andrew K., additional, Golbin, Denis, additional, Hanhan, Ziad, additional, Hannick, Linda I., additional, Hariharan, Pushpa, additional, Hindenach, Barbara, additional, Hoadley, Katherine A., additional, Hostetter, Galen, additional, Huang, Chen, additional, Jaehnig, Eric, additional, Jewell, Scott D., additional, Ji, Nan, additional, Jones, Corbin D., additional, Karz, Alcida, additional, Kaspera, Wojciech, additional, Kim, Lyndon, additional, Kothadia, Ramani B., additional, Kumar-Sinha, Chandan, additional, Lei, Jonathan, additional, Leprevost, Felipe D., additional, Li, Kai, additional, Liao, Yuxing, additional, Lilly, Jena, additional, Liu, Hongwei, additional, Lubínski, Jan, additional, Madan, Rashna, additional, Maggio, William, additional, Malc, Ewa, additional, Malovannaya, Anna, additional, Mareedu, Sailaja, additional, Markey, Sanford P., additional, Marrero-Oliveras, Annette, additional, Martinez, Nina, additional, Maunganidze, Nicollette, additional, McDermott, Jason E., additional, McGarvey, Peter B., additional, McGee, John, additional, Mieczkowski, Piotr, additional, Migliozzi, Simona, additional, Modugno, Francesmary, additional, Montgomery, Rebecca, additional, Newton, Chelsea J., additional, Omenn, Gilbert S., additional, Ozbek, Umut, additional, Paklina, Oxana V., additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Pico, Alexander R., additional, Piehowski, Paul D., additional, Placantonakis, Dimitris G., additional, Polonskaya, Larisa, additional, Potapova, Olga, additional, Pruetz, Barbara, additional, Qi, Liqun, additional, Ramkissoon, Shakti, additional, Resnick, Adam, additional, Richey, Shannon, additional, Riggins, Gregory, additional, Robinson, Karna, additional, Roche, Nancy, additional, Rohrer, Daniel C., additional, Rood, Brian R., additional, Rossell, Larissa, additional, Savage, Sara R., additional, Schadt, Eric E., additional, Shi, Yan, additional, Shi, Zhiao, additional, Shutack, Yvonne, additional, Singh, Shilpi, additional, Skelly, Tara, additional, Sokoll, Lori J., additional, Stawicki, Jakub, additional, Stein, Stephen E., additional, Suh, James, additional, Szopa, Wojciech, additional, Tabor, Dave, additional, Tan, Donghui, additional, Tansil, Darlene, additional, Thangudu, Ratna R., additional, Tognon, Cristina, additional, Traer, Elie, additional, Tsang, Shirley, additional, Tyner, Jeffrey, additional, Um, Ki Sung, additional, Valley, Dana R., additional, Vasaikar, Suhas, additional, Vatanian, Negin, additional, Velvulou, Uma, additional, Vernon, Michael, additional, Wan, Weiqing, additional, Wang, Junmei, additional, Webster, Alex, additional, Wen, Bo, additional, Whiteaker, Jeffrey R., additional, Wilson, George D., additional, Zakhartsev, Yuriy, additional, Zelt, Robert, additional, Zhang, Hui, additional, Zhang, Liwei, additional, Zhang, Zhen, additional, Zhao, Grace, additional, and Zhu, Jun, additional

Published
2021
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19. Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma

Author

Huang, Chen, primary, Chen, Lijun, additional, Savage, Sara R., additional, Eguez, Rodrigo Vargas, additional, Dou, Yongchao, additional, Li, Yize, additional, da Veiga Leprevost, Felipe, additional, Jaehnig, Eric J., additional, Lei, Jonathan T., additional, Wen, Bo, additional, Schnaubelt, Michael, additional, Krug, Karsten, additional, Song, Xiaoyu, additional, Cieślik, Marcin, additional, Chang, Hui-Yin, additional, Wyczalkowski, Matthew A., additional, Li, Kai, additional, Colaprico, Antonio, additional, Li, Qing Kay, additional, Clark, David J., additional, Hu, Yingwei, additional, Cao, Liwei, additional, Pan, Jianbo, additional, Wang, Yuefan, additional, Cho, Kyung-Cho, additional, Shi, Zhiao, additional, Liao, Yuxing, additional, Jiang, Wen, additional, Anurag, Meenakshi, additional, Ji, Jiayi, additional, Yoo, Seungyeul, additional, Zhou, Daniel Cui, additional, Liang, Wen-Wei, additional, Wendl, Michael, additional, Vats, Pankaj, additional, Carr, Steven A., additional, Mani, D.R., additional, Zhang, Zhen, additional, Qian, Jiang, additional, Chen, Xi S., additional, Pico, Alexander R., additional, Wang, Pei, additional, Chinnaiyan, Arul M., additional, Ketchum, Karen A., additional, Kinsinger, Christopher R., additional, Robles, Ana I., additional, An, Eunkyung, additional, Hiltke, Tara, additional, Mesri, Mehdi, additional, Thiagarajan, Mathangi, additional, Weaver, Alissa M., additional, Sikora, Andrew G., additional, Lubiński, Jan, additional, Wierzbicka, Małgorzata, additional, Wiznerowicz, Maciej, additional, Satpathy, Shankha, additional, Gillette, Michael A., additional, Miles, George, additional, Ellis, Matthew J., additional, Omenn, Gilbert S., additional, Rodriguez, Henry, additional, Boja, Emily S., additional, Dhanasekaran, Saravana M., additional, Ding, Li, additional, Nesvizhskii, Alexey I., additional, El-Naggar, Adel K., additional, Chan, Daniel W., additional, Zhang, Hui, additional, Zhang, Bing, additional, Agarwal, Anupriya, additional, Anderson, Matthew L., additional, Avanessian, Shayan C., additional, Avtonomov, Dmitry, additional, Bathe, Oliver F., additional, Birger, Chet, additional, Birrer, Michael J., additional, Blumenberg, Lili, additional, Bocik, William E., additional, Borate, Uma, additional, Borucki, Melissa, additional, Burke, Meghan C., additional, Cai, Shuang, additional, Calinawan, Anna Pamela, additional, Cerda, Sandra, additional, Charamut, Alyssa, additional, Chen, Lin S., additional, Chowdhury, Shrabanti, additional, Clauser, Karl R., additional, Culpepper, Houston, additional, Czernicki, Tomasz, additional, D'Angelo, Fulvio, additional, Day, Jacob, additional, De Young, Stephanie, additional, Demir, Emek, additional, Ding, Fei, additional, Domagalski, Marcin J., additional, Dort, Joseph C., additional, Druker, Brian, additional, Duffy, Elizabeth, additional, Dyer, Maureen, additional, Edwards, Nathan J., additional, Elburn, Kimberly, additional, Ermakova, Tatiana S., additional, Fenyo, David, additional, Ferrarotto, Renata, additional, Francis, Alicia, additional, Gabriel, Stacey, additional, Garofano, Luciano, additional, Geffen, Yifat, additional, Getz, Gad, additional, Goldthwaite, Charles A., additional, Hannick, Linda I., additional, Hariharan, Pushpa, additional, Hayes, David N., additional, Heiman, David, additional, Hindenach, Barbara, additional, Hoadley, Katherine A., additional, Hostetter, Galen, additional, Hyrcza, Martin, additional, Jewell, Scott D., additional, Jones, Corbin D., additional, Kane, M. Harry, additional, Karz, Alicia, additional, Kothadia, Ramani B., additional, Krek, Azra, additional, Kumar-Sinha, Chandan, additional, Liu, Tao, additional, Liu, Hongwei, additional, Ma, Weiping, additional, Malc, Ewa, additional, Malovannaya, Anna, additional, Mareedu, Sailaja, additional, Markey, Sanford P., additional, Marrero-Oliveras, Annette, additional, Maunganidze, Nicollette, additional, McDermott, Jason E., additional, McGarvey, Peter B., additional, McGee, John, additional, Mieczkowski, Piotr, additional, Migliozzi, Simona, additional, Montgomery, Rebecca, additional, Newton, Chelsea J., additional, Ozbek, Umut, additional, Paulovich, Amanda G., additional, Payne, Samuel H., additional, Pazardzhikliev, Dimitar Dimitrov, additional, Perou, Amy M., additional, Petralia, Francesca, additional, Petrenko, Lyudmila, additional, Piehowski, Paul D., additional, Placantonakis, Dmitris, additional, Polonskaya, Larisa, additional, Ponomareva, Elena V., additional, Potapova, Olga, additional, Qi, Liqun, additional, Qu, Ning, additional, Ramkissoon, Shakti, additional, Reva, Boris, additional, Richey, Shannon, additional, Robinson, Karna, additional, Roche, Nancy, additional, Rodland, Karin, additional, Rohrer, Daniel C., additional, Rykunov, Dmitry, additional, Schadt, Eric E., additional, Shi, Yan, additional, Shutack, Yvonne, additional, Singh, Shilpi, additional, Skelly, Tara, additional, Smith, Richard, additional, Sokoll, Lori J., additional, Stawicki, Jakub, additional, Stein, Stephen E., additional, Suh, James, additional, Szopa, Wojciech, additional, Tabor, Dave, additional, Tan, Donghui, additional, Tansil, Darlene, additional, Teo, Guo Ci, additional, Thangudu, Ratna R., additional, Tognon, Cristina, additional, Traer, Elie, additional, Tsang, Shirley, additional, Tyner, Jeffrey, additional, Um, Ki Sung, additional, Valley, Dana R., additional, Vasilev, Lyubomir Valkov, additional, Vatanian, Negin, additional, Velvulou, Uma, additional, Vernon, Michael, additional, Westbrook, Thomas F., additional, Whiteaker, Jeffrey R., additional, Wu, Yige, additional, Xu, Midie, additional, Yao, Lijun, additional, Yi, Xinpei, additional, Yu, Fengchao, additional, Zaalishvili, Kakhaber, additional, Zakhartsev, Yuriy, additional, Zelt, Robert, additional, Zhao, Grace, additional, and Zhu, Jun, additional

Published
2021
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20. Myocardial Injury in Severe COVID-19 Compared With Non–COVID-19 Acute Respiratory Distress Syndrome

Author

Metkus, Thomas S., primary, Sokoll, Lori J., additional, Barth, Andreas S., additional, Czarny, Matthew J., additional, Hays, Allison G., additional, Lowenstein, Charles J., additional, Michos, Erin D., additional, Nolley, Eric P., additional, Post, Wendy S., additional, Resar, Jon R., additional, Thiemann, David R., additional, Trost, Jeffrey C., additional, and Hasan, Rani K., additional

Published
2021
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21. A panel of selected serum protein biomarkers for the detection of aggressive prostate cancer

Author

Song, Jin, primary, Ma, Shiyong, additional, Sokoll, Lori J., additional, Eguez, Rodrigo V., additional, Höti, Naseruddin, additional, Zhang, Hui, additional, Mohr, Phaedre, additional, Dua, Renu, additional, Patil, Dattatraya, additional, May, Kristen Douglas, additional, Williams, Sierra, additional, Arnold, Rebecca, additional, Sanda, Martin G., additional, Chan, Daniel W., additional, and Zhang, Zhen, additional

Published
2021
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24. Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

Author

Gillette, Michael A., primary, Satpathy, Shankha, additional, Cao, Song, additional, Dhanasekaran, Saravana M., additional, Vasaikar, Suhas V., additional, Krug, Karsten, additional, Petralia, Francesca, additional, Li, Yize, additional, Liang, Wen-Wei, additional, Reva, Boris, additional, Krek, Azra, additional, Ji, Jiayi, additional, Song, Xiaoyu, additional, Liu, Wenke, additional, Hong, Runyu, additional, Yao, Lijun, additional, Blumenberg, Lili, additional, Savage, Sara R., additional, Wendl, Michael C., additional, Wen, Bo, additional, Li, Kai, additional, Tang, Lauren C., additional, MacMullan, Melanie A., additional, Avanessian, Shayan C., additional, Kane, M. Harry, additional, Newton, Chelsea J., additional, Cornwell, MacIntosh, additional, Kothadia, Ramani B., additional, Ma, Weiping, additional, Yoo, Seungyeul, additional, Mannan, Rahul, additional, Vats, Pankaj, additional, Kumar-Sinha, Chandan, additional, Kawaler, Emily A., additional, Omelchenko, Tatiana, additional, Colaprico, Antonio, additional, Geffen, Yifat, additional, Maruvka, Yosef E., additional, da Veiga Leprevost, Felipe, additional, Wiznerowicz, Maciej, additional, Gümüş, Zeynep H., additional, Veluswamy, Rajwanth R., additional, Hostetter, Galen, additional, Heiman, David I., additional, Wyczalkowski, Matthew A., additional, Hiltke, Tara, additional, Mesri, Mehdi, additional, Kinsinger, Christopher R., additional, Boja, Emily S., additional, Omenn, Gilbert S., additional, Chinnaiyan, Arul M., additional, Rodriguez, Henry, additional, Li, Qing Kay, additional, Jewell, Scott D., additional, Thiagarajan, Mathangi, additional, Getz, Gad, additional, Zhang, Bing, additional, Fenyö, David, additional, Ruggles, Kelly V., additional, Cieslik, Marcin P., additional, Robles, Ana I., additional, Clauser, Karl R., additional, Govindan, Ramaswamy, additional, Wang, Pei, additional, Nesvizhskii, Alexey I., additional, Ding, Li, additional, Mani, D.R., additional, Carr, Steven A., additional, Webster, Alex, additional, Francis, Alicia, additional, Charamut, Alyssa, additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Godwin, Andrew K., additional, Karnuta, Andrii, additional, Marrero-Oliveras, Annette, additional, Hindenach, Barbara, additional, Pruetz, Barbara, additional, Kubisa, Bartosz, additional, Druker, Brian J., additional, Birger, Chet, additional, Jones, Corbin D., additional, Valley, Dana R., additional, Rohrer, Daniel C., additional, Zhou, Daniel Cui, additional, Chan, Daniel W., additional, Chesla, David, additional, Clark, David J., additional, Rykunov, Dmitry, additional, Tan, Donghui, additional, Ponomareva, Elena V., additional, Duffy, Elizabeth, additional, Burks, Eric J., additional, Schadt, Eric E., additional, Bergstrom, Erik J., additional, Fedorov, Eugene S., additional, Malc, Ewa, additional, Wilson, George D., additional, Chen, Hai-Quan, additional, Krzystek, Halina M., additional, Liu, Hongwei, additional, Culpepper, Houston, additional, Sun, Hua, additional, Zhang, Hui, additional, Day, Jacob, additional, Suh, James, additional, Whiteaker, Jeffrey R., additional, Eschbacher, Jennifer, additional, McGee, John, additional, Ketchum, Karen A., additional, Rodland, Karin D., additional, Robinson, Karna, additional, Hoadley, Katherine A., additional, Suzuki, Kei, additional, Um, Ki Sung, additional, Elburn, Kim, additional, Wang, Liang-Bo, additional, Chen, Lijun, additional, Hannick, Linda, additional, Qi, Liqun, additional, Sokoll, Lori J., additional, Wojtyś, Małgorzata, additional, Domagalski, Marcin J., additional, Gritsenko, Marina A., additional, Beasley, Mary B., additional, Monroe, Matthew E., additional, Ellis, Matthew J., additional, Dyer, Maureen, additional, Burke, Meghan C., additional, Borucki, Melissa, additional, Sun, Meng-Hong, additional, Roehrl, Michael H., additional, Birrer, Michael J., additional, Noble, Michael, additional, Schnaubelt, Michael, additional, Vernon, Michael, additional, Chaikin, Michelle, additional, Krotevich, Mikhail, additional, Khan, Munziba, additional, Selvan, Myvizhi Esai, additional, Roche, Nancy, additional, Edwards, Nathan J., additional, Vatanian, Negin, additional, Potapova, Olga, additional, Grady, Pamela, additional, McGarvey, Peter B., additional, Mieczkowski, Piotr, additional, Hariharan, Pushpa, additional, Madan, Rashna, additional, Thangudu, Ratna R., additional, Smith, Richard D., additional, Welsh, Robert J., additional, Zelt, Robert, additional, Mehra, Rohit, additional, Matteotti, Ronald, additional, Mareedu, Sailaja, additional, Payne, Samuel H., additional, Cottingham, Sandra, additional, Markey, Sanford P., additional, Chugh, Seema, additional, Smith, Shaleigh, additional, Tsang, Shirley, additional, Cai, Shuang, additional, Boca, Simina M., additional, Carter, Sonya, additional, Gabriel, Stacey, additional, De Young, Stephanie, additional, Stein, Stephen E., additional, Shankar, Sunita, additional, Krubit, Tanya, additional, Liu, Tao, additional, Skelly, Tara, additional, Bauer, Thomas, additional, Velvulou, Uma, additional, Ozbek, Umut, additional, Petyuk, Vladislav A., additional, Sovenko, Volodymyr, additional, Bocik, William E., additional, Maggio, William W., additional, Chen, Xi, additional, Shi, Yan, additional, Wu, Yige, additional, Hu, Yingwei, additional, Liao, Yuxing, additional, Zhang, Zhen, additional, and Shi, Zhiao, additional

Published
2020
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25. Proteogenomic Characterization of Endometrial Carcinoma

Author

Dou, Yongchao, primary, Kawaler, Emily A., additional, Cui Zhou, Daniel, additional, Gritsenko, Marina A., additional, Huang, Chen, additional, Blumenberg, Lili, additional, Karpova, Alla, additional, Petyuk, Vladislav A., additional, Savage, Sara R., additional, Satpathy, Shankha, additional, Liu, Wenke, additional, Wu, Yige, additional, Tsai, Chia-Feng, additional, Wen, Bo, additional, Li, Zhi, additional, Cao, Song, additional, Moon, Jamie, additional, Shi, Zhiao, additional, Cornwell, MacIntosh, additional, Wyczalkowski, Matthew A., additional, Chu, Rosalie K., additional, Vasaikar, Suhas, additional, Zhou, Hua, additional, Gao, Qingsong, additional, Moore, Ronald J., additional, Li, Kai, additional, Sethuraman, Sunantha, additional, Monroe, Matthew E., additional, Zhao, Rui, additional, Heiman, David, additional, Krug, Karsten, additional, Clauser, Karl, additional, Kothadia, Ramani, additional, Maruvka, Yosef, additional, Pico, Alexander R., additional, Oliphant, Amanda E., additional, Hoskins, Emily L., additional, Pugh, Samuel L., additional, Beecroft, Sean J.I., additional, Adams, David W., additional, Jarman, Jonathan C., additional, Kong, Andy, additional, Chang, Hui-Yin, additional, Reva, Boris, additional, Liao, Yuxing, additional, Rykunov, Dmitry, additional, Colaprico, Antonio, additional, Chen, Xi Steven, additional, Czekański, Andrzej, additional, Jędryka, Marcin, additional, Matkowski, Rafał, additional, Wiznerowicz, Maciej, additional, Hiltke, Tara, additional, Boja, Emily, additional, Kinsinger, Christopher R., additional, Mesri, Mehdi, additional, Robles, Ana I., additional, Rodriguez, Henry, additional, Mutch, David, additional, Fuh, Katherine, additional, Ellis, Matthew J., additional, DeLair, Deborah, additional, Thiagarajan, Mathangi, additional, Mani, D.R., additional, Getz, Gad, additional, Noble, Michael, additional, Nesvizhskii, Alexey I., additional, Wang, Pei, additional, Anderson, Matthew L., additional, Levine, Douglas A., additional, Smith, Richard D., additional, Payne, Samuel H., additional, Ruggles, Kelly V., additional, Rodland, Karin D., additional, Ding, Li, additional, Zhang, Bing, additional, Liu, Tao, additional, Fenyö, David, additional, Agarwal, Anupriya, additional, Anurag, Meenakshi, additional, Avtonomov, Dmitry, additional, Birger, Chet, additional, Birrer, Michael J., additional, Boca, Simina M., additional, Bocik, William E., additional, Borate, Uma, additional, Borucki, Melissa, additional, Burke, Meghan C., additional, Cai, Shuang, additional, Calinawan, Anna, additional, Carr, Steven A., additional, Carter, Sonya, additional, Castro, Patricia, additional, Cerda, Sandra, additional, Chaikin, Michelle, additional, Chan, Daniel W., additional, Chan, Doug, additional, Charamut, Alyssa, additional, Chen, Feng, additional, Chen, Jin, additional, Chen, Lijun, additional, Chen, Lin S., additional, Chesla, David, additional, Chheda, Milan G., additional, Chinnaiyan, Arul M., additional, Chowdhury, Shrabanti, additional, Cieslik, Marcin P., additional, Clark, David J., additional, Cottingham, Sandra, additional, Culpepper, Houston, additional, Day, Jacob, additional, De Young, Stephanie, additional, Demir, Emek, additional, Dhanasekaran, Saravana Mohan, additional, Dhir, Rajiv, additional, Domagalski, Marcin J., additional, Dottino, Peter, additional, Druker, Brian, additional, Duffy, Elizabeth, additional, Dyer, Maureen, additional, Edwards, Nathan J., additional, Edwards, Robert, additional, Elburn, Kim, additional, Field, Jayson B., additional, Francis, Alicia, additional, Gabriel, Stacey, additional, Geffen, Yifat, additional, Geiszler, Daniel, additional, Gillette, Michael A., additional, Godwin, Andrew K., additional, Grady, Pamela, additional, Hannick, Linda, additional, Hariharan, Pushpa, additional, Hilsenbeck, Sue, additional, Hindenach, Barbara, additional, Hoadley, Katherine A., additional, Hong, Runyu, additional, Hostetter, Galen, additional, Hsieh, James J., additional, Hu, Yingwei, additional, Ittmann, Michael M., additional, Jaehnig, Eric, additional, Jewell, Scott D., additional, Ji, Jiayi, additional, Jones, Corbin D., additional, Karabon, Renee, additional, Ketchum, Karen A., additional, Khan, Munziba, additional, Kim, Beom-Jun, additional, Krek, Azra, additional, Krubit, Tanya, additional, Kumar-Sinha, Chandan, additional, Leprevost, Felipe D., additional, Lewis, Michael, additional, Li, Qing Kay, additional, Li, Yize, additional, Liu, Hongwei, additional, Lubinski, Jan, additional, Ma, Weiping, additional, Madan, Rashna, additional, Malc, Ewa, additional, Malovannaya, Anna, additional, Mareedu, Sailaja, additional, Markey, Sanford P., additional, Marrero-Oliveras, Annette, additional, Martignetti, John, additional, McDermott, Jason, additional, McGarvey, Peter B., additional, McGee, John, additional, Mieczkowski, Piotr, additional, Modugno, Francesmary, additional, Montgomery, Rebecca, additional, Newton, Chelsea J., additional, Omenn, Gilbert S., additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Petralia, Francesca, additional, Piehowski, Paul, additional, Polonskaya, Larisa, additional, Qi, Liqun, additional, Richey, Shannon, additional, Robinson, Karna, additional, Roche, Nancy, additional, Rohrer, Daniel C., additional, Schadt, Eric E., additional, Schnaubelt, Michael, additional, Shi, Yan, additional, Skelly, Tara, additional, Sokoll, Lori J., additional, Song, Xiaoyu, additional, Stein, Stephen E., additional, Suh, James, additional, Tan, Donghui, additional, Tansil, Darlene, additional, Teo, Guo Ci, additional, Thangudu, Ratna R., additional, Tognon, Cristina, additional, Traer, Elie, additional, Tyner, Jeffrey, additional, Um, Ki Sung, additional, Valley, Dana R., additional, Vatanian, Negin, additional, Vats, Pankaj, additional, Velvulou, Uma, additional, Vernon, Michael, additional, Wang, Liang-Bo, additional, Wang, Ying, additional, Webster, Alex, additional, Westbrook, Thomas, additional, Wheeler, David, additional, Whiteaker, Jeffrey R., additional, Wilson, George D., additional, Zakhartsev, Yuriy, additional, Zelt, Robert, additional, Zhang, Hui, additional, Zhang, Yuping, additional, Zhang, Zhen, additional, and Zhao, Grace, additional

Published
2020
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26. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Author

Clark, David J., primary, Dhanasekaran, Saravana M., additional, Petralia, Francesca, additional, Pan, Jianbo, additional, Song, Xiaoyu, additional, Hu, Yingwei, additional, da Veiga Leprevost, Felipe, additional, Reva, Boris, additional, Lih, Tung-Shing M., additional, Chang, Hui-Yin, additional, Ma, Weiping, additional, Huang, Chen, additional, Ricketts, Christopher J., additional, Chen, Lijun, additional, Krek, Azra, additional, Li, Yize, additional, Rykunov, Dmitry, additional, Li, Qing Kay, additional, Chen, Lin S., additional, Ozbek, Umut, additional, Vasaikar, Suhas, additional, Wu, Yige, additional, Yoo, Seungyeul, additional, Chowdhury, Shrabanti, additional, Wyczalkowski, Matthew A., additional, Ji, Jiayi, additional, Schnaubelt, Michael, additional, Kong, Andy, additional, Sethuraman, Sunantha, additional, Avtonomov, Dmitry M., additional, Ao, Minghui, additional, Colaprico, Antonio, additional, Cao, Song, additional, Cho, Kyung-Cho, additional, Kalayci, Selim, additional, Ma, Shiyong, additional, Liu, Wenke, additional, Ruggles, Kelly, additional, Calinawan, Anna, additional, Gümüş, Zeynep H., additional, Geiszler, Daniel, additional, Kawaler, Emily, additional, Teo, Guo Ci, additional, Wen, Bo, additional, Zhang, Yuping, additional, Keegan, Sarah, additional, Li, Kai, additional, Chen, Feng, additional, Edwards, Nathan, additional, Pierorazio, Phillip M., additional, Chen, Xi Steven, additional, Pavlovich, Christian P., additional, Hakimi, A. Ari, additional, Brominski, Gabriel, additional, Hsieh, James J., additional, Antczak, Andrzej, additional, Omelchenko, Tatiana, additional, Lubinski, Jan, additional, Wiznerowicz, Maciej, additional, Linehan, W. Marston, additional, Kinsinger, Christopher R., additional, Thiagarajan, Mathangi, additional, Boja, Emily S., additional, Mesri, Mehdi, additional, Hiltke, Tara, additional, Robles, Ana I., additional, Rodriguez, Henry, additional, Qian, Jiang, additional, Fenyö, David, additional, Zhang, Bing, additional, Ding, Li, additional, Schadt, Eric, additional, Chinnaiyan, Arul M., additional, Zhang, Zhen, additional, Omenn, Gilbert S., additional, Cieslik, Marcin, additional, Chan, Daniel W., additional, Nesvizhskii, Alexey I., additional, Wang, Pei, additional, Zhang, Hui, additional, Hashimi, Abdul Samad, additional, Pico, Alexander R., additional, Karpova, Alla, additional, Charamut, Alyssa, additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Malovannaya, Anna, additional, Marrero-Oliveras, Annette, additional, Agarwal, Anupriya, additional, Hindenach, Barbara, additional, Pruetz, Barbara, additional, Kim, Beom-Jun, additional, Druker, Brian J., additional, Newton, Chelsea J., additional, Birger, Chet, additional, Jones, Corbin D., additional, Tognon, Cristina, additional, Mani, D.R., additional, Valley, Dana R., additional, Rohrer, Daniel C., additional, Zhou, Daniel C., additional, Tansil, Darlene, additional, Chesla, David, additional, Heiman, David, additional, Wheeler, David, additional, Tan, Donghui, additional, Chan, Doug, additional, Demir, Emek, additional, Malc, Ewa, additional, Modugno, Francesmary, additional, Getz, Gaddy, additional, Hostetter, Galen, additional, Wilson, George D., additional, Hart, Gerald W., additional, Zhu, Heng, additional, Liu, Hongwei, additional, Culpepper, Houston, additional, Sun, Hua, additional, Zhou, Hua, additional, Day, Jacob, additional, Suh, James, additional, Huang, Jasmine, additional, McDermott, Jason, additional, Whiteaker, Jeffrey R., additional, Tyner, Jeffrey W., additional, Eschbacher, Jennifer, additional, Chen, Jin, additional, McGee, John, additional, Zhu, Jun, additional, Ketchum, Karen A., additional, Rodland, Karin D., additional, Clauser, Karl, additional, Robinson, Karna, additional, Krug, Karsten, additional, Hoadley, Katherine A., additional, Um, Ki Sung, additional, Elburn, Kim, additional, Holloway, Kimberly, additional, Wang, Liang-Bo, additional, Blumenberg, Lili, additional, Hannick, Linda, additional, Qi, Liqun, additional, Sokoll, Lori J., additional, Cornwell, MacIntosh, additional, Loriaux, Marc, additional, Domagalski, Marcin J., additional, Gritsenko, Marina A., additional, Anderson, Matthew, additional, Monroe, Matthew E., additional, Ellis, Matthew J., additional, Dyer, Maureen, additional, Anurag, Meenakshi, additional, Burke, Meghan C., additional, Borucki, Melissa, additional, Gillette, Michael A., additional, Birrer, Michael J., additional, Lewis, Michael, additional, Ittmann, Michael M., additional, Smith, Michael, additional, Vernon, Michael, additional, Chaikin, Michelle, additional, Chheda, Milan G., additional, Khan, Munziba, additional, Roche, Nancy, additional, Edwards, Nathan J., additional, Vatanian, Negin, additional, Tignor, Nicole, additional, Beckmann, Noam, additional, Grady, Pamela, additional, Castro, Patricia, additional, Piehowski, Paul, additional, McGarvey, Peter B., additional, Mieczkowski, Piotr, additional, Hariharan, Pushpa, additional, Gao, Qingsong, additional, Dhir, Rajiv, additional, Kothadia, Ramani Bhupendra, additional, Thangudu, Ratna R., additional, Montgomery, Rebecca, additional, Jayasinghe, Reyka G., additional, Smith, Richard D., additional, Edwards, Robert, additional, Zelt, Robert, additional, Bremner, Ross, additional, Liu, Ruiyang, additional, Hong, Runyu, additional, Mareedu, Sailaja, additional, Payne, Samuel H., additional, Cottingham, Sandra, additional, Markey, Sanford P., additional, Jewell, Scott D., additional, Patel, Shalin, additional, Satpathy, Shankha, additional, Richey, Shannon, additional, Davies, Sherri R., additional, Cai, Shuang, additional, Boca, Simina M., additional, Patil, Snehal, additional, Sengupta, Sohini, additional, Carter, Sonya, additional, Gabriel, Stacey, additional, Thomas, Stefani N., additional, De Young, Stephanie, additional, Stein, Stephen E., additional, Carr, Steven A., additional, Foltz, Steven M., additional, Hilsenbeck, Sue, additional, Krubit, Tanya, additional, Liu, Tao, additional, Skelly, Tara, additional, Westbrook, Thomas, additional, Borate, Uma, additional, Velvulou, Uma, additional, Petyuk, Vladislav A., additional, Bocik, William E., additional, Chen, Xi, additional, Shi, Yan, additional, Geffen, Yifat, additional, Lu, Yihao, additional, Wang, Ying, additional, Maruvka, Yosef, additional, Li, Zhi, additional, Shi, Zhiao, additional, and Tu, Zhidong, additional

Published
2020
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27. Urinary glycoproteins associated with aggressive prostate cancer

Author

Dong, Mingming, primary, Lih, T. Mamie, additional, Chen, Shao-Yung, additional, Cho, Kyung-Cho, additional, Eguez, Rodrigo Vargas, additional, Höti, Naseruddin, additional, Zhou, Yangying, additional, Yang, Weiming, additional, Mangold, Leslie, additional, Chan, Daniel W., additional, Zhang, Zhen, additional, Sokoll, Lori J., additional, Partin, Alan, additional, and Zhang, Hui, additional

Published
2020
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32. Total, free and complexed PSA and hK2 for early detection of prostate cancer. (Cover Story)

Author

Haese, Alexander, Khan, Masood A., and Sokoll, Lori J.

Subjects
Health care industry, Prostate-specific antigen -- Research, Health care industry -- Research
Abstract

Prostate-specific antigen (PSA) is a valuable tool for the early detection and management of prostate carcinoma. It is, however, an imperfect tool because of poor specificity in the face of [...]

Published
2003

34. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Author

Clark, David J., primary, Dhanasekaran, Saravana M., additional, Petralia, Francesca, additional, Pan, Jianbo, additional, Song, Xiaoyu, additional, Hu, Yingwei, additional, da Veiga Leprevost, Felipe, additional, Reva, Boris, additional, Lih, Tung-Shing M., additional, Chang, Hui-Yin, additional, Ma, Weiping, additional, Huang, Chen, additional, Ricketts, Christopher J., additional, Chen, Lijun, additional, Krek, Azra, additional, Li, Yize, additional, Rykunov, Dmitry, additional, Li, Qing Kay, additional, Chen, Lin S., additional, Ozbek, Umut, additional, Vasaikar, Suhas, additional, Wu, Yige, additional, Yoo, Seungyeul, additional, Chowdhury, Shrabanti, additional, Wyczalkowski, Matthew A., additional, Ji, Jiayi, additional, Schnaubelt, Michael, additional, Kong, Andy, additional, Sethuraman, Sunantha, additional, Avtonomov, Dmitry M., additional, Ao, Minghui, additional, Colaprico, Antonio, additional, Cao, Song, additional, Cho, Kyung-Cho, additional, Kalayci, Selim, additional, Ma, Shiyong, additional, Liu, Wenke, additional, Ruggles, Kelly, additional, Calinawan, Anna, additional, Gümüş, Zeynep H., additional, Geiszler, Daniel, additional, Kawaler, Emily, additional, Teo, Guo Ci, additional, Wen, Bo, additional, Zhang, Yuping, additional, Keegan, Sarah, additional, Li, Kai, additional, Chen, Feng, additional, Edwards, Nathan, additional, Pierorazio, Phillip M., additional, Chen, Xi Steven, additional, Pavlovich, Christian P., additional, Hakimi, A. Ari, additional, Brominski, Gabriel, additional, Hsieh, James J., additional, Antczak, Andrzej, additional, Omelchenko, Tatiana, additional, Lubinski, Jan, additional, Wiznerowicz, Maciej, additional, Linehan, W. Marston, additional, Kinsinger, Christopher R., additional, Thiagarajan, Mathangi, additional, Boja, Emily S., additional, Mesri, Mehdi, additional, Hiltke, Tara, additional, Robles, Ana I., additional, Rodriguez, Henry, additional, Qian, Jiang, additional, Fenyö, David, additional, Zhang, Bing, additional, Ding, Li, additional, Schadt, Eric, additional, Chinnaiyan, Arul M., additional, Zhang, Zhen, additional, Omenn, Gilbert S., additional, Cieslik, Marcin, additional, Chan, Daniel W., additional, Nesvizhskii, Alexey I., additional, Wang, Pei, additional, Zhang, Hui, additional, Hashimi, Abdul Samad, additional, Pico, Alexander R., additional, Karpova, Alla, additional, Charamut, Alyssa, additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Malovannaya, Anna, additional, Marrero-Oliveras, Annette, additional, Agarwal, Anupriya, additional, Hindenach, Barbara, additional, Pruetz, Barbara, additional, Kim, Beom-Jun, additional, Druker, Brian J., additional, Newton, Chelsea J., additional, Birger, Chet, additional, Jones, Corbin D., additional, Tognon, Cristina, additional, Mani, D.R., additional, Valley, Dana R., additional, Rohrer, Daniel C., additional, Zhou, Daniel C., additional, Tansil, Darlene, additional, Chesla, David, additional, Heiman, David, additional, Wheeler, David, additional, Tan, Donghui, additional, Chan, Doug, additional, Demir, Emek, additional, Malc, Ewa, additional, Modugno, Francesmary, additional, Getz, Gaddy, additional, Hostetter, Galen, additional, Wilson, George D., additional, Hart, Gerald W., additional, Zhu, Heng, additional, Liu, Hongwei, additional, Culpepper, Houston, additional, Sun, Hua, additional, Zhou, Hua, additional, Day, Jacob, additional, Suh, James, additional, Huang, Jasmine, additional, McDermott, Jason, additional, Whiteaker, Jeffrey R., additional, Tyner, Jeffrey W., additional, Eschbacher, Jennifer, additional, Chen, Jin, additional, McGee, John, additional, Zhu, Jun, additional, Ketchum, Karen A., additional, Rodland, Karin D., additional, Clauser, Karl, additional, Robinson, Karna, additional, Krug, Karsten, additional, Hoadley, Katherine A., additional, Um, Ki Sung, additional, Elburn, Kim, additional, Holloway, Kimberly, additional, Wang, Liang-Bo, additional, Blumenberg, Lili, additional, Hannick, Linda, additional, Qi, Liqun, additional, Sokoll, Lori J., additional, Cornwell, MacIntosh, additional, Loriaux, Marc, additional, Domagalski, Marcin J., additional, Gritsenko, Marina A., additional, Anderson, Matthew, additional, Monroe, Matthew E., additional, Ellis, Matthew J., additional, Dyer, Maureen, additional, Anurag, Meenakshi, additional, Burke, Meghan C., additional, Borucki, Melissa, additional, Gillette, Michael A., additional, Birrer, Michael J., additional, Lewis, Michael, additional, Ittmann, Michael M., additional, Smith, Michael, additional, Vernon, Michael, additional, Chaikin, Michelle, additional, Chheda, Milan G., additional, Khan, Munziba, additional, Roche, Nancy, additional, Edwards, Nathan J., additional, Vatanian, Negin, additional, Tignor, Nicole, additional, Beckmann, Noam, additional, Grady, Pamela, additional, Castro, Patricia, additional, Piehowski, Paul, additional, McGarvey, Peter B., additional, Mieczkowski, Piotr, additional, Hariharan, Pushpa, additional, Gao, Qingsong, additional, Dhir, Rajiv, additional, Kothadia, Ramani Bhupendra, additional, Thangudu, Ratna R., additional, Montgomery, Rebecca, additional, Jayasinghe, Reyka G., additional, Smith, Richard D., additional, Edwards, Robert, additional, Zelt, Robert, additional, Bremner, Ross, additional, Liu, Ruiyang, additional, Hong, Runyu, additional, Mareedu, Sailaja, additional, Payne, Samuel H., additional, Cottingham, Sandra, additional, Markey, Sanford P., additional, Jewell, Scott D., additional, Patel, Shalin, additional, Satpathy, Shankha, additional, Richey, Shannon, additional, Davies, Sherri R., additional, Cai, Shuang, additional, Boca, Simina M., additional, Patil, Snehal, additional, Sengupta, Sohini, additional, Carter, Sonya, additional, Gabriel, Stacey, additional, Thomas, Stefani N., additional, De Young, Stephanie, additional, Stein, Stephen E., additional, Carr, Steven A., additional, Foltz, Steven M., additional, Hilsenbeck, Sue, additional, Krubit, Tanya, additional, Liu, Tao, additional, Skelly, Tara, additional, Westbrook, Thomas, additional, Borate, Uma, additional, Velvulou, Uma, additional, Petyuk, Vladislav A., additional, Bocik, William E., additional, Chen, Xi, additional, Shi, Yan, additional, Geffen, Yifat, additional, Lu, Yihao, additional, Wang, Ying, additional, Maruvka, Yosef, additional, Li, Zhi, additional, Shi, Zhiao, additional, and Tu, Zhidong, additional

Published
2019
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36. Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects

Author

Sokoll, Lori J., Booth, Sarah L., O'Brien, Maureen E., Davidson, Kenneth W., Tsaioun, Katherine I., and Sadowski, James A.

Subjects
Vitamin K -- Physiological aspects, Nutrition -- Evaluation, Amino acid metabolism -- Health aspects, Food/cooking/nutrition, Health
Abstract

The response of osteocalcin and other biochemical markers of vitamin K status to diets formulated to contain different amounts of phylloquinone was assessed in nine healthy subjects aged 20-33 y. Subjects resided in a metabolic ward for two 15-d cycles with a minimum of 6 wk between cycles. A mixed diet containing 100 [mu]g phylloquinone/d was fed throughout both cycles; however, the phylloquinone content of one of the cycles was increased to a total of 420 [mu]g/d on days 6 through 10 by fortifying corn oil in the diet with phylloquinone (supplemented diet). Total serum osteocalcin concentrations were not affected by either of the dietary treatments. The percentage of undercarboxylated osteocalcin increased an average of 28% over the 15-d cycle with the mixed diet (P [is less than] and declined significantly an average of 41% with 5 d of the supplemented diet (day 6: 21.9 [+ or -] 1.3, day 11: 12.8 [+ or -] 1.1%; P = 0.0001) with a rise after the return to the mixed diet (16.7 [+ or -] 1.3%, P [is less than] 0.001). Plasma phylloquinone concentrations increased significantly with supplementation (day 6: 0.95 [+ or -] 0.16 nmol/L, day 11: 1.40 [+ or -] 0.29 nmol/L; P [is less than] 0.001) and then rapidly returned to presupplementation concentrations on returning to the mixed diet. Twenty-four-hour ratios of urinary [gamma]-carboxyglutamic acid to creatinine were unchanged with the supplemented diet; however, excretion declined to 91 [+ or -] 2% of baseline after 10 d on the mixed diet (P = 0.01). These results show that undercarboxylated osteocalcin, plasma phylloquinone, and urinary [gamma]-carboxyglutamic acid excretion appear to be sensitive measures of vitamin K nutritional status because all of these variables were responsive to changes in dietary intake. Am J Clin Nutr 1997;65:779-84.

Published
1997

37. Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population

Author

Sokoll, Lori J. and Sadowski, James A.

Subjects
Vitamin K -- Health aspects, Nutrition -- Evaluation, Aging -- Health aspects, Food/cooking/nutrition, Health
Abstract

Biochemical indexes for assessing vitamin K nutritional status were evaluated in 263 healthy subjects (127 males, 136 females) aged 18-85 y. The influences of aging (stratified by decade), menopause, and sex were examined. Total, carboxylated, and undercarboxylated osteocalcin concentrations were affected by sex and aging with increases in the sixth decade in women attributed to menopause. Aging effects in the women and sex differences were eliminated when undercarboxylated osteocalcin was expressed as a percentage of the total. Plasma phylloquinone and undercarboxylated prothrombin (PIVKA-II) concentrations varied little with aging with the exception of lower concentrations of phylloquinone in women in their third decade compared with other ages and higher concentrations of PIVKA-II in younger males compared with younger females. Urinary [gamma]-carboxyglutamic acid (Gla)-creatinine excretion ratios increased significantly with age in both males (r = 0.68, P < 0.001) and females (r = 0.63, P < 0.001) with values 20% higher in the females on average over the entire age span. The undercarboxylated osteocalcin concentration, shown previously to be responsive to depletion and repletion of phylloquinone, was compared with the other indexes to determine its reliability as an indicator of vitamin K nutritional status. This measure appears promising because it correlated with plasma PIVKA-II concentrations (r = 0.27, P < 0.001) and with plasma phylloquinone concentrations (r = -0.35, P < 0.001), whereas the agreement between plasma phylloquinone and PIVKA-II concentrations was not as strong (r = -0.15, P < 0.05).

Published
1996

38. Re: Association Between Combined TMPRSS2:ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer

Author

Sanda, Martin G, Feng, Ziding, Howard, David H, Tomlins, Scott A, Sokoll, Lori J, Chan, Daniel W, Regan, Meredith M, Groskopf, Jack, Chipman, Jonathan, Patil, Dattatraya H, Salami, Simpa S, Scherr, Douglas S, Kagan, Jacob, Srivastava, Sudhir, Thompson, Ian M, Siddiqui, Javed, Fan, Jing, Joon, Aron Y, Bantis, Leonidas E, Rubin, Mark Andrew, Chinnayian, Arul M, Wei, John T, Bidair, Mohamed, Kibel, Adam, Lin, Daniel W, Lotan, Yair, Partin, Alan, and Taneja, Samir

Subjects
Adult, Male, PCA3, Oncology, Cancer Research, medicine.medical_specialty, Prostate biopsy, genetic structures, Oncogene Proteins, Fusion, Urology, Urinary system, 030232 urology & nephrology, Urinalysis, urologic and male genital diseases, TMPRSS2, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Transcriptional Regulator ERG, Prostate, Antigens, Neoplasm, Internal medicine, Biomarkers, Tumor, medicine, Humans, Neoplasm, Overdiagnosis, Prospective cohort study, Original Investigation, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Prostatic Neoplasms, RNA, Middle Aged, 500 Science, medicine.disease, Prostate-specific antigen, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Costs and Cost Analysis, 570 Life sciences, biology, Neoplasm Grading, business, Erg
Abstract

Importance Potential survival benefits from treating aggressive (Gleason score, ≥7) early-stage prostate cancer are undermined by harms from unnecessary prostate biopsy and overdiagnosis of indolent disease. Objective To evaluate the a priori primary hypothesis that combined measurement of PCA3 and TMPRSS2:ERG ( T2:ERG ) RNA in the urine after digital rectal examination would improve specificity over measurement of prostate-specific antigen alone for detecting cancer with Gleason score of 7 or higher. As a secondary objective, to evaluate the potential effect of such urine RNA testing on health care costs. Design, Setting, and Participants Prospective, multicenter diagnostic evaluation and validation in academic and community-based ambulatory urology clinics. Participants were a referred sample of men presenting for first-time prostate biopsy without preexisting prostate cancer: 516 eligible participants from among 748 prospective cohort participants in the developmental cohort and 561 eligible participants from 928 in the validation cohort. Interventions/Exposures Urinary PCA3 and T2:ERG RNA measurement before prostate biopsy. Main Outcomes and Measures Presence of prostate cancer having Gleason score of 7 or higher on prostate biopsy. Pathology testing was blinded to urine assay results. In the developmental cohort, a multiplex decision algorithm was constructed using urine RNA assays to optimize specificity while maintaining 95% sensitivity for predicting aggressive prostate cancer at initial biopsy. Findings were validated in a separate multicenter cohort via prespecified analysis, blinded per prospective-specimen-collection, retrospective-blinded-evaluation (PRoBE) criteria. Cost effects of the urinary testing strategy were evaluated by modeling observed biopsy results and previously reported treatment outcomes. Results Among the 516 men in the developmental cohort (mean age, 62 years; range, 33-85 years) combining testing of urinary T2:ERG and PCA3 at thresholds that preserved 95% sensitivity for detecting aggressive prostate cancer improved specificity from 18% to 39%. Among the 561 men in the validation cohort (mean age, 62 years; range, 27-86 years), analysis confirmed improvement in specificity (from 17% to 33%; lower bound of 1-sided 95% CI, 0.73%; prespecified 1-sided P = .04), while high sensitivity (93%) was preserved for aggressive prostate cancer detection. Forty-two percent of unnecessary prostate biopsies would have been averted by using the urine assay results to select men for biopsy. Cost analysis suggested that this urinary testing algorithm to restrict prostate biopsy has greater potential cost-benefit in younger men. Conclusions and Relevance Combined urinary testing for T2:ERG and PCA3 can avert unnecessary biopsy while retaining robust sensitivity for detecting aggressive prostate cancer with consequent potential health care cost savings.

Published
2018

39. Identification of Serum Biomarker Panels for the Early Detection of Pancreatic Cancer.

Author

Jin Song, Sokoll, Lori J., Pasay, Jered J., Rubin, Abigail L., Hanying Li, Bach, Dylan M., Chan, Daniel W., and Zhen Zhang

Abstract

Background: Pancreatic cancer is a deadly disease for which available biomarkers, such as CA19-9, lack the desired sensitivity and specificity for early detection. Additional biomarkers are needed to improve both its sensitivity and specificity. Methods: Multiplex immunoassays were developed for selected biomarkers using a Bio-Plex 200 system, and analytical performance was optimized. All proteins were analyzed in sera of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC; n = 188) or benign pancreatic conditions (131) and healthy controls (89). The clinical performance of these markers was evaluated individually or in combination for their ability to complement CA19-9 for the early detection of pancreatic cancer. Results: A 6-plex immunoassay was developed with negligible cross-reactivity, wide dynamic range, recovery of 89% to 104%, and intra-assay and interassay precision of 10.2% to 19.6% and 13.7% to 29.3%, respectively. Individually, the best biomarkers to separate PDAC early stage from chronic pancreatitis or intraductal papillary mucinous neoplasm (IPMN) were CA19-9 and MIA or CA19-9 and MIC-1. Logistic regression modeling selected the two-marker panels that significantly improved the individual biomarker performance in discriminating PDAC early stage from chronic pancreatitis (AUCCA19-9+MIA = 0.86 vs. AUCCA19-9 = 0.81 or AUCMIA = 0.75 only, P < 0.05) or IPMN (AUCCA19-9+MIC-1 = 0.81 vs. AUCCA19-9 = 0.75 or AUCMIC-1 = 0.73 only, P < 0.05). It was observed that osteopontin (OPN) outperformed CA19-9 in separating IPMN from chronic pancreatitis (AUCOPN = 0.80 vs. AUCCA19-9 = 0.70, P < 0.01). Conclusions: The biomarker panels evaluated by assays with high analytical performance demonstrated potential complementary values to CA19-9, warranting additional clinical validation to determine their role in early detection of pancreatic cancer. Impact: The validated biomarker panels could lead to earlier intervention and better outcomes. [ABSTRACT FROM AUTHOR]

Published
2019
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40. Redesigned Proficiency Testing Materials Improve Survey Outcomes for Prostate-Specific Antigen

Author

Sokoll, Lori J., Witte, David L., Klee, George G., and Chan, Daniel W.

Subjects
Prostate-specific antigen -- Measurement, Prostate cancer -- Diagnosis
Abstract

* Context.--Large disparities in prostate-specific antigen (PSA) results from different assays have been observed in the College of American Pathologists (CAP) Ligand Assay Survey, with interassay results varying severalfold. Survey specimens are predominately composed of free PSA and do not reflect the composition of typical patient specimens. Objectives.--To characterize a pilot material developed for CAP in which pooled sera samples were spiked with purified PSA and [[Alpha].sub.1]-antichymotrypsin-bound PSA at targeted concentrations and to compare it to CAP survey and reference materials. Design.--CAP survey, reference, and pilot materials were analyzed using 10 total PSA and 7 free PSA assays. These assays included Food and Drug Administration-approved assays and assays for research use only. Results.--Variability among the 10 total PSA methods was greatest for the 1997 ligand survey material (CV range, 56%-65%) followed by the pilot material (CV range, 10%-29%) and the reference material (CV range, 6%-13%). In contrast, interassay variability for the 7 free PSA methods was similar for the 3 preparations, with the exception of one specimen close to the limit of detection of the assays. As determined with the Hybritech Tandem-R method, the ligand survey specimens were essentially composed of all free PSA, whereas the reference and pilot materials were composed of approximately 10% and 35% free PSA, respectively. Conclusions.--The newly formulated pilot material prepared using a human base that contained defined concentrations of free PSA and [[Alpha].sub.1]-antichymotrypsin-bound PSA more closely resembled patient specimens and minimized differences among methods compared with the semen-supplemented original survey material. (Arch Pathol Lab Med. 2000;124:1608-1613), A College of American Pathologists Ligand Assay Survey Study Large disparities in prostate-specific antigen (PSA) results from different assays have been observed in the College of American Pathologists (CAP) Ligand [...]

Published
2000

44. A Multi-Center Study of [−2]Pro-Prostate-Specific Antigen (PSA) in Combination with PSA and Free PSA for Prostate Cancer Detection in the 2.0 to 10.0 ng/mL PSA Range

Author

Catalona, William J., Partin, Alan W., Sanda, Martin G., Wei, John T., Klee, George G., Bangma, Chris H., Slawin, Kevin M., Marks, Leonard S., Loeb, Stacy, Broyles, Dennis L., Shin, Sanghyuk S., Cruz, Amabelle B., Chan, Daniel W., Sokoll, Lori J., Roberts, William L., van Schaik, Ron H.N., and Mizrahi, Isaac A.

Subjects
Male, Chi-Square Distribution, Biopsy, Age Factors, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, Sensitivity and Specificity, Article, Double-Blind Method, Predictive Value of Tests, Area Under Curve, Case-Control Studies, Biomarkers, Tumor, Humans, Mass Screening, Regression Analysis, Prospective Studies, Aged
Abstract

Prostate specific antigen and free prostate specific antigen have limited specificity to detect clinically significant, curable prostate cancer, leading to unnecessary biopsy, and detection and treatment of some indolent tumors. Specificity to detect clinically significant prostate cancer may be improved by [-2]pro-prostate specific antigen. We evaluated [-2]pro-prostate specific antigen, free prostate specific antigen and prostate specific antigen using the formula, ([-2]pro-prostate specific antigen/free prostate specific antigen × prostate specific antigen(1/2)) to enhance specificity to detect overall and high grade prostate cancer.We enrolled 892 men with no history of prostate cancer, normal rectal examination, prostate specific antigen 2 to 10 ng/ml and 6-core or greater prostate biopsy in a prospective multi-institutional trial. We examined the relationship of serum prostate specific antigen, free-to-total prostate specific antigen and the prostate health index with biopsy results. Primary end points were specificity and AUC using the prostate health index to detect overall and Gleason 7 or greater prostate cancer on biopsy compared with those of free-to-total prostate specific antigen.In the 2 to 10 ng/ml prostate specific antigen range at 80% to 95% sensitivity the specificity and AUC (0.703) of the prostate health index exceeded those of prostate specific antigen and free-to-total prostate specific antigen. An increasing prostate health index was associated with a 4.7-fold increased risk of prostate cancer and a 1.61-fold increased risk of Gleason score greater than or equal to 4 + 3 = 7 disease on biopsy. The AUC of the index exceeded that of free-to-total prostate specific antigen (0.724 vs 0.670) to discriminate prostate cancer with Gleason 4 or greater + 3 from lower grade disease or negative biopsy. Prostate health index results were not associated with age and prostate volume.The prostate health index may be useful in prostate cancer screening to decrease unnecessary biopsy in men 50 years old or older with prostate specific antigen 2 to 10 ng/ml and negative digital rectal examination with minimal loss in sensitivity.

Published
2011

46. proPSA Measurements in Serum and Tissue are Associated with Treatment Necessity Among Men Enrolled in Expectant Management for Prostate Cancer

Author

Makarov, Danil V., Isharwal, Sumit, Sokoll, Lori J., Landis, Patricia, Marlow, Cameron, Epstein, Jonathan I., Partin, Alan W., Carter, H. Ballentine, and Veltri, Robert W.

Subjects
Male, Biopsy, Biomarkers, Tumor, Humans, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, Medical Oncology, Article, Aged, Neoplasm Staging, Proportional Hazards Models
Abstract

We assessed the association of quantitative clinical and pathologic information, including serum and tissue pro-prostate-specific antigen (proPSA) measurements, with outcomes among men with prostate cancer in an expectant management (active surveillance) program.We identified 71 men enrolled in expectant management with frozen serum and tissue available from diagnosis: 39 subsequently developed unfavorable biopsies (Gleason scoreor =7,or =3 cores positive for cancer,50% of any core involved with cancer), whereas 32 maintained favorable biopsies (median follow-up, 3.93 years). Serum total PSA, free PSA (fPSA), and [-2]proPSA were measured by the Beckman Coulter immunoassay. [-5/-7]proPSA was evaluated in cancer and benign-adjacent areas (BAA) by quantitative immunohistochemistry. Cox proportional hazards and Kaplan-Meier analyses were used to identify significant associations with unfavorable biopsy conversion.The ratio [-2]proPSA/% fPSA in serum was significantly higher at diagnosis (0.87 +/- 0.44 versus 0.65 +/- 0.36 pg/mL; P = 0.02) in men developing unfavorable biopsies. [-5/-7]proPSA tissue staining was more intense (4104.09 +/- 3033.50 versus 2418.06 +/- 1606.04; P = 0.03) and comprised a greater fractional area (11.58 +/- 7.08% versus 6.88 +/- 5.20%; P = 0.01) in BAA of these men. Serum [-2]proPSA/% fPSA [hazard ratio, 2.53 (1.18-5.41); P = 0.02], BAA [-5/-7]proPSA % area [hazard ratio, 1.06 (1.01-1.12); P = 0.02] and BAA [-5/-7]proPSA stain intensity [hazard ratio, 1.000213 (1.000071-1.000354); P = 0.003] were significantly associated with unfavorable biopsy in Kaplan-Meier and Cox analyses. Serum [-2]proPSA/% fPSA significantly correlated with BAA [-5/-7]proPSA % area (rho = 0.40; P = 0.002) and BAA [-5/-7]proPSA stain intensity (rho = 0.33; P = 0.016).In a prospective cohort of men enrolled into expectant management for prostate cancer, serum and tissue levels of proPSA at diagnosis are associated with need for subsequent treatment. The increase in serum proPSA/% fPSA might be driven by increased proPSA production from "premalignant" cells in the prostate BAA.

Published
2009

48. Abstract 1268: Accurate measurement of serum total and free PSA using immunoaffinity depletion coupled to SRM: Correlation with clinical immunoassays

Author

Liu, Tao, primary, Shi, Tujin, additional, Hossain, Mahmud, additional, Schepmoes, Athena, additional, Fillmore, Thomas, additional, Sokoll, Lori J., additional, Chan, Daniel, additional, Leach, Robin, additional, Thompson, Ian, additional, Smith, Richard D., additional, Kagan, Jacob, additional, Srivastava, Sudhir, additional, Rodland, Karin D., additional, Camp, David G., additional, and Qian, Wei-Jun, additional

Published
2012
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50. Fifth-Generation Digital Immunoassay for Prostate-Specific Antigen by Single Molecule Array Technology

Author

Wilson, David H, primary, Hanlon, David W, primary, Provuncher, Gail K, primary, Chang, Lei, primary, Song, Linan, primary, Patel, Purvish P, primary, Ferrell, Evan P, primary, Lepor, Herbert, primary, Partin, Alan W, primary, Chan, Dan W, primary, Sokoll, Lori J, primary, Cheli, Carol D, primary, Thiel, Robert P, primary, Fournier, David R, primary, and Duffy, David C, primary

Published
2011
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