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2. Association of Unfavorable Social Determinants of Health With Stroke/Transient Ischemic Attack and Vascular Risk Factors in Hispanic/Latino Adults: Results From Hispanic Community Health Study/Study of Latinos

Author

Trifan, Gabriela, primary, Gallo, Linda C., additional, Lamar, Melissa, additional, Garcia-Bedoya, Olga, additional, Perreira, Krista M., additional, Pirzada, Amber, additional, Talavera, Gregory A., additional, Smoller, Sylvia W., additional, Isasi, Carmen R., additional, Cai, Jianwen, additional, Daviglus, Martha L., additional, and Testai, Fernando D., additional

Published
2023
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3. Abstract P179: The Association Of A Genetic Risk Score With Prevalent Coronary Heart Disease In The Hispanic Community Health Study/Study Of Latinos (HCHS/SOL)

Author

Hutten, Christina G, primary, Durazo-Arvizu, Ramon, additional, Scannell Bryan, Molly, additional, Preudhomme, Liana, additional, Perreira, Krista, additional, Talavera, Gregory, additional, Smoller, Sylvia W, additional, Sun, Jiehuan, additional, Persky, Victoria W, additional, Sofer, Tamar, additional, Daviglus, Martha L, additional, and Argos, Maria, additional

Published
2022
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4. Abstract 064: Prevalence Of Stroke Symptoms Among Hispanic/Latino Adults In The Hispanic Community Health Study/study Of Latinos (HCHS/SOL)

Author

Jimenez, Monik C, primary, Lopez, Joanna, additional, Castaneda, Sheila F, additional, Daviglus, Martha L, additional, Kaplan, Robert, additional, Lopez, Lenny, additional, perreira, krista, additional, Rodriguez, Fatima, additional, Wassertheil-smoller, Sylvia W, additional, Sotres-Alvarez, Daniela, additional, Springer, Mellanie, additional, Talavera, Gregory A, additional, Testai, Fernando, additional, and Rexrode, Kathryn M, additional

Published
2022
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5. Sex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke

Author

Tomppo, Liisa, Rannikmae, Kristiina, Stanne, Tara M., Putaala, Jukka, Strbian, Daniel, Jern, Christina, de Leeuw, Frank Erik, Cadenas, Israel Fernandez, Slowik, Agnieszka M., Boncoraglio, Giorgio, Lindgren, Arne, Conde, Jordi J., Schmidt, Reinhold, Sharma, Pankaj, Lemmens, Robin, Melander, Olle, Rothwell, Peter, Levi, Christopher, Sudlow, Catherine, Debette, Stephanie, Metso, Tiina, Pare, Guillaume, Markus, Hugh, Saleheen, Danish, Danesh, John, Zand, Ramin, Worrall, Bradford B., Meschia, James F., Rundek, Tatjana, Woo, Daniel, Lee, Jin Moo, Irvin, Marguerite R., Mcdonough, Caitrin W., Rexrode, Kathryn M., Wassertheil-Smoller, Sylvia W., Rosand, Jonathan, Gieger, Christian, Muller-Nurasyid, Martina, Salomaa, Veikko V., Kamatani, Yoichiro, Walters, Robin, Chen, Zhengming, Dichgans, Martin, Malik, Rainer, Gaynor, Brady, Cole, John, Xu, Huichun, Mitchell, Braxton D., Kittner, Steven J., Early-Onset Stroke, Consortium, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Ischemic stroke, Gender differences, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Genome-wide association studies (GWAS)
Abstract

Introduction: Genetic studies of early-onset disease have been an effective strategy to identify novel pathways and drug targets generalizable also to later-onset disease. Few studies have investigated the sex-specific genetic associations with early-onset ischemic stroke even though several features of ischemic stroke differ between males and females. We hypothesized that stratifying the GWAS by sex would reveal novel stroke loci. Methods: We performed a transethnic ischemic stroke GWAS of 3,056 female cases and 4,462 male cases < 60 years-old and 16,192 and 16,048 sex-matched controls, respectively, from the Early Onset Stroke Genetics Consortium. Results: We identified a significant association in women with a locus in close proximity to TMX1, a transmembrane platelet protein that inhibits platelet function. Additionally, we identified 2 other suggestive (P < 5 x 10-6) loci in females (see Table), i.e., at APOH, which encodes beta2-glycoprotein I, an established GWAS locus for lipoprotein(a), and LRFN2 which has been previously reported to associate with obesity-related measures and type II diabetes. We observed suggestive evidence for association in males with MMP3/MMP12, a known stroke susceptibility locus. Conclusions: Despite a very modest sample size, sex-specific analyses identified suggestive associations at biologically important novel loci in females and a known stroke locus in males. Further studies of sex-specific associations in both early- and later-onset ischemic stroke are needed.

Published
2022

7. Abstract MP60: Blood Pressure Variability And Risk Of Heart Failure In Postmenopausal Women. Results From The Women's Health Initiative.

Author

Haring, Bernhard, primary, Hunt, Rebecca, additional, Manson, JoAnn, additional, Lamonte, Michael J, additional, Klein, Liviu, additional, Allison, Matthew A, additional, Wild, Robert A, additional, Wallace, Robert B, additional, Shadyab, Aladdin, additional, Breathett, Khadijah, additional, Eaton, Charles B, additional, Wassertheil-smoller, Sylvia W, additional, and Shimbo, Daichi, additional

Published
2021
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8. Abstract P188: Anxiety Is Associated With Six-year Blood Pressure Change And Incident Hypertension: Findings From The Hispanic Community Health Study/ Study Of Latinos

Author

Rosas, Carlos E, primary, Pirzada, Amber, additional, Durazo-Arvizu, Ramon A, additional, Sanchez-Johnsen, Lisa A, additional, perreira, krista, additional, Gallo, Linda, additional, Talavera, Gregory A, additional, Elfassy, Tali, additional, Wassertheil-smoller, Sylvia W, additional, Llabre, Maria, additional, Cai, Jianwen, additional, and Daviglus, Martha L, additional

Published
2021
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9. Abstract P508: Association of Egg and Dietary Cholesterol Intake With Incident Cardiovascular Disease and All-cause Mortality

Author

Chen, Guochong, primary, Chen, Li-Hua, additional, Mossavar-Rahmani, Yasmin, additional, Kamensky, Victor, additional, Shadyab, Aladdin, additional, Silver, Brian, additional, Wild, Robert A, additional, Sun, Yangbo, additional, Haring, Bernhard, additional, Neuhouser, Marian, additional, Kuller, Lewis H, additional, Howard, Barbara V, additional, Saquib, Nazmus, additional, Snetselaar, Linda, additional, Allison, Matthew A, additional, VAN HORN, Linda, additional, Manson, Joann E, additional, Wassertheil-Smoller, Sylvia W, additional, and Qi, Qibin, additional

Published
2020
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11. Abstract 154: Sex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke

Author

Tomppo, Liisa, Rannikmae, Kristiina, Stanne, Tara M, Putaala, Jukka, Strbian, Daniel, Jern, Christina, de Leeuw, Frank-Erik, Cadenas, Israel Fernandez, Slowik, Agnieszka M, Boncoraglio, Giorgio, Lindgren, Arne, Conde, Jordi J, Schmidt, Reinhold, Sharma, Pankaj, Lemmens, Robin, MELANDER, Olle, Rothwell, Peter, Levi, Christopher, Sudlow, Catherine, Debette, Stephanie, Metso, Tiina, Pare, Guillaume, Markus, Hugh, Saleheen, Danish, Danesh, John, Zand, Ramin, Worrall, Bradford B, Meschia, James F, Rundek, Tatjana, Woo, Daniel, Lee, Jin-moo, Irvin, Marguerite R, McDonough, Caitrin W, Rexrode, Kathryn M, Wassertheil-smoller, Sylvia W, Rosand, Jonathan, Gieger, Christian, Muller-Nurasyid, Martina, Salomaa, Veikko V, Kamatani, Yoichiro, Walters, Robin, Chen, Zhengming, Dichgans, Martin, Malik, Rainer, Gaynor, Brady, Cole, John, Xu, Huichun, Mitchell, Braxton D, and Kittner, Steven J

Abstract

Introduction:Genetic studies of early-onset disease have been an effective strategy to identify novel pathways and drug targets generalizable also to later-onset disease. Few studies have investigated the sex-specific genetic associations with early-onset ischemic stroke even though several features of ischemic stroke differ between males and females. We hypothesized that stratifying the GWAS by sex would reveal novel stroke loci.Methods:We performed a transethnic ischemic stroke GWAS of 3,056 female cases and 4,462 male cases < 60 years-old and 16,192 and 16,048 sex-matched controls, respectively, from the Early Onset Stroke Genetics Consortium.Results:We identified a significant association in women with a locus in close proximity to TMX1, a transmembrane platelet protein that inhibits platelet function. Additionally, we identified 2 other suggestive (P < 5 x 10-6) loci in females (see Table), i.e., at APOH, which encodes beta2-glycoprotein I, an established GWAS locus for lipoprotein(a), and LRFN2which has been previously reported to associate with obesity-related measures and type II diabetes. We observed suggestive evidence for association in males with MMP3/MMP12, a known stroke susceptibility locus.Conclusions:Despite a very modest sample size, sex-specific analyses identified suggestive associations at biologically important novel loci in females and a known stroke locus in males. Further studies of sex-specific associations in both early- and later-onset ischemic stroke are needed.

Published
2022
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12. Abstract T P153.

Author

Rexrode, Kathryn M, Mitchell, Braxton D, Ryan, Kathleen A, Kittner, Steven J, Ay, Hakan, Wassertheil-Smoller, Sylvia W, and Rundek, Tatjana

Published
2014

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