3,404 results on '"Smith, Mary"'
Search Results
2. Standardized Definitions for Efficacy End Points in Neoadjuvant Breast Cancer Clinical Trials: NeoSTEEP.
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Tolaney, Sara, Garrett-Mayer, Elizabeth, Amiri-Kordestani, Laleh, Basho, Reva, Best, Ana, Boileau, Jean-Francois, Denkert, Carsten, Foster, Jared, Harbeck, Nadia, Jacene, Heather, King, Tari, Mason, Ginny, OSullivan, Ciara, Prowell, Tatiana, Richardson, Andrea, Sepulveda, Karla, Smith, Mary, Tjoe, Judy, Turashvili, Gulisa, Woodward, Wendy, Butler, Lynn, Schwartz, Elena, Korde, Larissa, Litton, Jennifer, Regan, Meredith, Pusztai, Lajos, and Rugo, Hope
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Humans ,Female ,Breast Neoplasms ,Neoadjuvant Therapy ,Research Design ,Progression-Free Survival - Abstract
PURPOSE: The Standardized Definitions for Efficacy End Points (STEEP) criteria, established in 2007 and updated in 2021 (STEEP 2.0), provide standardized definitions of adjuvant breast cancer (BC) end points. STEEP 2.0 identified a need to separately address end points for neoadjuvant clinical trials. The multidisciplinary NeoSTEEP working group of experts was convened to critically evaluate and align neoadjuvant BC trial end points. METHODS: The NeoSTEEP working group concentrated on neoadjuvant systemic therapy end points in clinical trials with efficacy outcomes-both pathologic and time-to-event survival end points-particularly for registrational intent. Special considerations for subtypes and therapeutic approaches, imaging, nodal staging at surgery, bilateral and multifocal diseases, correlative tissue collection, and US Food and Drug Administration regulatory considerations were contemplated. RESULTS: The working group recommends a preferred definition of pathologic complete response (pCR) as the absence of residual invasive cancer in the complete resected breast specimen and all sampled regional lymph nodes (ypT0/Tis ypN0 per AJCC staging). Residual cancer burden should be a secondary end point to facilitate future assessment of its utility. Alternative end points are needed for hormone receptor-positive disease. Time-to-event survival end point definitions should pay particular attention to the measurement starting point. Trials should include end points originating at random assignment (event-free survival and overall survival) to capture presurgery progression and deaths as events. Secondary end points adapted from STEEP 2.0, which are defined from starting at curative-intent surgery, may also be appropriate. Specification and standardization of biopsy protocols, imaging, and pathologic nodal evaluation are also crucial. CONCLUSION: End points in addition to pCR should be selected on the basis of clinical and biologic aspects of the tumor and the therapeutic agent investigated. Consistent prespecified definitions and interventions are paramount for clinically meaningful trial results and cross-trial comparison.
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- 2023
3. Discerning the impact of ctDNA detection on patient decision-making in early-stage breast cancer
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Ballinger, Tarah J., Smith, Mary Lou, Railey, Elda, Zimet, Greg, and Schneider, Bryan P.
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- 2024
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4. Advocate-BREAST: advocates and patients’ advice to enhance breast cancer care delivery, patient experience and patient centered research by 2025
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O’Sullivan, Ciara C., Larson, Nicole L., Vierkant, Robert A., Smith, Mary Lou, Chauhan, Cynthia, Couch, Fergus J., Olson, Janet E., Loprinzi, Charles L., and Ruddy, Kathryn J.
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- 2024
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5. Court and Piety in Late Anglo-Saxon England
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Smith, Mary Frances, Fleming, Robin, and Halpin, Patricia
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- 2001
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6. Lawyers Must Protect Democracy Now
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Smith, Mary L.
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Government regulation ,Suffrage -- Laws, regulations and rules ,Public employees -- Laws, regulations and rules -- Safety and security measures ,Attorneys -- Laws, regulations and rules ,Threats -- Laws, regulations and rules ,Democracy -- Analysis -- Safety and security measures ,U.S. Capitol Insurrection, 2021 -- Evaluation - Abstract
We are at a defining moment in our country. Over the last four years--most strikingly on Jan. 6, 2021--we have seen violent attacks on our democratic institutions. Make no mistake, [...]
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- 2024
7. The Condition of Education 2020. NCES 2020-144
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National Center for Education Statistics (ED), American Institutes for Research (AIR), Hussar, Bill, Zhang, Jijun, Hein, Sarah, Wang, Ke, Roberts, Ashley, Cui, Jiashan, Smith, Mary, Mann, Farrah Bullock, Barmer, Amy, and Dilig, Rita
- Abstract
The "Condition of Education" is an annual report mandated by the U.S. Congress that summarizes the latest data on education in the United States. This report uses data from across the National Center for Education Statistics (NCES) and from other sources and is designed to help policymakers and the public monitor educational progress. This year's report includes 47 indicators on topics ranging from prekindergarten through postsecondary education, as well as labor force outcomes and international comparisons. [For "The Condition of Education 2019. NCES 2019-144," see ED594978.]
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- 2020
8. The ABA's Unyielding Fidelity to Diversity
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Smith, Mary L.
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Affirmative action -- Laws, regulations and rules ,Intercultural education -- Laws, regulations and rules ,Minority law students -- Statistics ,Law schools -- Admission ,Minority attorneys -- Statistics -- Employment -- Management ,Workplace multiculturalism -- Laws, regulations and rules ,Government regulation ,Company business management ,Law ,American Bar Association -- Demographic aspects -- Services -- Aims and objectives - Abstract
Following the June 2023 U.S. Supreme Court ruling dismantling affirmative action in higher education, the legal world has witnessed significant repercussions. Some law firms and law schools have been sued, [...]
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- 2024
9. Using electronic consultation (eConsult) to identify frailty in provider-to-provider communication: a feasibility and validation study
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Hakimjavadi, Ramtin, Karunananthan, Sathya, Fung, Celeste, Levi, Cheryl, Helmer-Smith, Mary, LaPlante, James, Gazarin, Mohamed, Rahgozar, Arya, Afkham, Amir, Keely, Erin, and Liddy, Clare
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- 2023
- Full Text
- View/download PDF
10. Risky Routes: Modified Personal Vehicles, Public Safety, and Postal Services Under the Federal Tort Claims Act
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Smith, Mary J.
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United States. Postal Service -- Laws, regulations and rules -- Safety and security measures ,Personal injuries -- Laws, regulations and rules ,Delivery services -- Laws, regulations and rules -- Safety and security measures ,Negligence -- Laws, regulations and rules ,Causation (Tort law) -- Laws, regulations and rules ,Employer liability -- Laws, regulations and rules ,Motor vehicles -- Laws, regulations and rules -- Demographic aspects -- Safety and security measures ,Government regulation ,Law ,Federal Tort Claims Act - Abstract
I. INTRODUCTION Who says the holiday spirit ever goes out of season? It is beginning to look a lot like Christmas year-round on many doorsteps as packages from online retailers [...]
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- 2023
11. Pop-up nursery
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Smith, Mary-Lovell
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- 2012
12. The ABA Leads Way on Access to Justice
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Smith, Mary
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Right to counsel -- Laws, regulations and rules ,Legal aid -- Government finance -- Laws, regulations and rules ,Prepaid legal services -- Laws, regulations and rules ,Pro bono legal services -- Management ,Government regulation ,Company business management ,Online legal information service ,Law ,Legal Services Corporation Act of 1974 ,American Bar Association -- Aims and objectives -- Services ,Legal Services Corp. (Washington, D.C.) -- Aims and objectives -- Evaluation - Abstract
This year marks the 50th anniversary of the Legal Services Corp., the United States' largest funder of civil legal aid. With a current congressional appropriation of $560 million, the LSC [...]
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- 2024
13. AI and the Legal Landscape: Do not fear a zombie apocalypse
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Smith, Mary L.
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Privacy, Right of -- Management ,Confidential communications -- Attorneys ,Artificial intelligence -- Usage -- Ethical aspects ,Law firms -- Management -- Innovations -- Ethical aspects ,Data security -- Management ,Company business management ,Data security issue ,Artificial intelligence ,Law ,ChatGPT (Language model) -- Ethical aspects -- Management -- Usage - Abstract
Last year, two New York attorneys submitted a legal brief that included six fictitious case citations generated by ChatGPT. In his ruling imposing sanctions on the men and their firm, [...]
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- 2024
14. Risk of COVID-19 after natural infection or vaccination
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Adams, Atoya, Miller, Eric, Rankin, Bruce G., Shinn, Steven, Nash, Marshall, Green, Sinikka L., Jacobsen, Colleen, Krishnankutty, Jayasree, Phungwayo, Sikhongi, Glover, Richard M., II, Slechta, Stacy, Holdeman, Troy, Hartvickson, Robyn, Grant, Amber, Poling, Terry L., Klein, Terry D., Klein, Thomas C., Klein, Tracy R., Smith, William B., Gibson, Richard L., Winbigler, Jennifer, Parker, Elizabeth, Wijewardane, Priyantha N., Bravo, Eric, Thessing, Jeffrey, Maxwell, Michelle, Horn, Amanda, Healy, Catherine Mary, Akamine, Christine, Chu, Laurence, Chouteau, R. Michelle, Cotugno, Michael J., Bauer, George H., Jr., Hachigian, Greg, Oshita, Masaru, Cancilla, Michael, Kiersey, Kristen, Seger, William, Antwi, Mohammed, Green, Allison, Kim, Anthony, Desjardins, Michael, Johnson, Jennifer A., Sherman, Amy, Walsh, Stephen R., Borger, Judith, Saleem, Nafisa, Solis, Joel, Medina, Martha Carmen, Keating, Westly, Garcia, Edgar, Bueno, Cynthia, Segall, Nathan, Denham, Douglas S., Weiss, Thomas, Avworo, Ayoade, Hedges, Parke, Strout, Cynthia Becher, Santiago, Rica, Davis, Yvonne, Howenstine, Patty, Bondell, Alison, Marks, Kristin, Wang, Tina, Wilkin, Timothy, Vogler, Mary, Johnston, Carrie, Andrasik, Michele P., Andriesen, Jessica G., Broder, Gail, Eaton, Niles, Gelderblom, Huub G., McClennen, Rachael, Michael, Nelson, Robb, Merlin, Sopher, Carrie, Miller, Vicki E., Santiago, Fredric, Gomez, Blanca, Valika, Insiya, Starr, Amy, Cantos, Valeria D., Kandiah, Sheetal, Rio, Carlos del, Rouphael, Nadine, Edupuganti, Srilatha, Anderson, Evan J., Camacho-Gonzalez, Andres, Kamidani, Satoshi, Teherani, Meghan, Diemert, David J., Malkin, Elissa, Siegel, Marc, Roberts, Afsoon, Simon, Gary, Balani, Bindu, Stephenson, Carolene, Sperber, Steven, Cicogna, Cristina, Zervos, Marcus J., Kilgore, Paul, Ramesh, Mayur, Herc, Erica, Zenlea, Kate, Burgher, Abram, Milliken, Ann M., Davis, Joseph D., Levy, Brendan, Kelman, Sandra, Doust, Matthew W., Sample, Denise, Erickson, Sandra, Christensen, Shane G., Matich, Christopher, Longe, James, Witbeck, John, Peterson, James T., Clark, Alexander, Kelty, Gerald, Pena-Renteria, Issac, Koren, Michael J., Bartilucci, Darlene, Patel, Alpa, Tran, Carolyn, Kennelly, Christina, Brownlee, Robert, Coleman, Jacob, Webster, Hala, Fierro, Carlos A., Leistner, Natalia, Thompson, Amy, Gonzalez, Celia, Jackson, Lisa A., Suyehira, Janice, Haber, Milton, Regalado, Maria M., Procasky, Veronica, Lutat, Alisha, Griffin, Carl P., Hollister, Ripley R., Brown, Jeremy, Ronk, Melody, Harper, Wayne L., Cohen, Lisa, Eckert, Lynn, Hong, Matthew, Rouhbakhsh, Rambod, Danford, Elizabeth, Johnson, John, Calderone, Richard, Khetan, Shishir K., Olanrewaju, Oyebisi, Zhai, Nan, Nieves, Kimberly, O'Brien, Allison, Bradley, Paul S., Lilienthal, Amanda, Callis, Jim, Brosz, Adam B., Clement, Andrea, West, Whitney, Friesen, Luke, Cramer, Paul, Eder, Frank S., Little, Ryan, Engler, Victoria, Rattenbury-Shaw, Heather, Ensz, David J., Oplinger, Allie, Essink, Brandon J., Meyer, Jay, Raiser, Frederick, III, Mueller, Kimberly, Vrbicky, Keith W., Harper, Charles, Nutsch, Chelsie, Lewis, Wendell, III, Laflan, Cathy, Whatley, Jordan L., Harrell, Nicole, Shannon, Amie, Rowell, Crystal, Dedon, Christopher, Makhene, Mamodikoe, Gottschlich, Gregory M., Harden, Kate, Gottschlich, Melissa, Smith, Mary, Powell, Richard, Kimmel, Murray A., Pinto, Simmy, Vachris, Timothy P., Hutchens, Mark, Daniels, Stephen, Wells, Margaret, Van Der Leden, Mimi, Jackson-Booth, Peta-Gay, Baron, Mira, Kane, Pamela, Seversen, Shannen, Kryvicky, Mara, Lord, Julia, Saleh, Jamshid, Miles, Matthew, Lupercio, Rafael, McGettigan, John W., Jr., Patton, Walter, Brakema, Riemke, Choquette, Karin, McGettigan, Jonlyn, Kirstein, Judith L., Bernard, Marcia, Manning, Mary Beth, Rothenberg, Joan, Briskin, Toby, Roadman, Denise, Tedder-Edwards, Sharita, Schwartz, Howard I., Mederos, Surisday, Swaminathan, Shobha, Nyaku, Amesika, Varughese, Tilly, DallaPiazza, Michelle, Frey, Sharon E., Graham, Irene, Abate, Getahun, Hoft, Daniel, Allen, Leland N., III, Edwards, Leslie A., Davis, William S., Jr., Mena, Jessica M., Kutner, Mark E., Caso, Jorge, Moran, Maria Hernandez, Carvajal, Marianela, Mendez, Janet, Wadsworth, Larkin T., III, Adams, Michael R., Iverson, Leslie, Newberg, Joseph L., Pearlman, Laura, Nugent, Paul J., Reynolds, Michele D., Bashour, Jennifer, Schmidt, Robert, Sheth, Neil P., Steil, Kenneth, Toma, Ramy J., Kirby, William, Folmar, Pink, Williams, Samantha, Pickrell, Paul, Mott, Stefanie, Linebarger, Carol Ann, Malbari, Hussain, Pampe, David, Fragoso, Veronica G., Holloway, Lisa, McKeown-Bragas, Cecilia, Becker, Teresa, Williams, Barton G., Jones, William H., Clark, Jesse L., Shoptaw, Steven, Vertucci, Michele, Hernandez, Will, Spector, Stephen A., Moodley, Amaran, Blumenthal, Jill, Stangl, Lisa, Deutsch, Karen, Mullane, Kathleen M., Pitrak, David, Nuss, Cheryl, Pi, Judy, Fichtenbaum, Carl, Powers-Fletcher, Margaret, Saemann, Michelle, Kohrs, Sharon, Campbell, Thomas B., Lauria, Andrew, Mancilla, Jose C., Dunlevy, Hillary, Novak, Richard M., Wendrow, Andrea, Borgetti, Scott, Ladner, Ben, Chrisley, Lisa, Young, Cheryl, Doblecki-Lewis, Susanne, Alcaide, Maria L., Gonzales-Zamora, Jose, Morris, Stephen, Wohl, David, Eron, Joseph, Jr., Frank, Ian, Dunbar, Debora, Metzger, David, Momplaisir, Florence, Martin, Judith, Hoberman, Alejandro, Shope, Timothy, Muniz, Gysella, Rupp, Richard, Stanford, Amber, Berman, Megan, Porterfield, Laura, Lewis, Michael, Ghadishah, Elham, Yusin, Joseph, Pham, Mai, Creech, Clarence B., II, Walker, Shannon, Rolsma, Stephanie, Samuels, Robert, Thomsen, Isaac, Kalams, Spyros A., Wilson, Greg, Lucksinger, Gregg H., Parks, Kevin, Israelsen, Ryan, Ostovar, Jaleh, Kelly, Kary, Overcash, Jeffrey S., Chu, Hanh, Lee, Kia, De La Cruz, Luis I., Clemons, Steve, Everette, Elizabeth, Studdard, Suzanna, Mohan, Gowdhami, Tyson, Stefanie, Peay, Alyssa-Kay, Johnson, Danyel, Feldman, Gregory J., Suen, May-Yin, Muenzner, Jacqueline, Boscia, Joseph, Siddiqui, Farhan, Sanders, John, Peacock, James, Nasim, Julio, Levin, Michael L., Hussey, Julie, Kulic, Marcy, McKenzie, Mark M., Deese, Teresa, Osmundsen, Erica, Sweet, Christy, Ebuh, Valentine M., Elnagar, Elwaleed, Ebuh, Georgette, Iwuala, Genevieve, Han-Conrad, Laurie J., Simmons, Todd, Tarakjian, Denis, Ackermann, Jeremy, Adams, Mark S., Alemán, José O., Al-Ibrahim, Mohamed S., Andes, David R., Andrews, Jeb, Arduino, Roberto C., Bäcker, Martín, Badillo, Diana, Bainbridge, Emma, Batteiger, Teresa A., Bazan, Jose A., Bedimo, Roger J., Benitez, Jorge A., Bennett, Annette R., Bernstein, David I., Bialobok, Kristin, Boas, Rebecca, Brady, Judith, Brown, Cynthia, Bunce, Catherine A., Call, Robert S., Campbell, Wesley, Carmody, Ellie, Carpenter, Christopher, Carsons, Steven E., Castellon, Marvin, Castro, Mario, Catan, Hannah, Chang, Jennifer, Chebib, Mouna G., Chen, Corey M., Cheng, Margaret, Chow, Brian D.W., Ciambruschini, Annie, Connor, Joseph P., Conway, James H., Cooney, Maureen, Curlin, Marcel, De La Matta Rodriguez, Claudia, Dedon, Jon F., Degan, Emily, Dickey, Michelle, Dietz, Craig, Dong, Jennifer L., Dorcely, Brenda, Dube, Michael P., Dyer, Carmel B., Eckhardt, Benjamin, Ellerbeck, Edward, Ewers, Evan C., Falk, Amy, Feijoo, Brittany, Felsen, Uriel R., Fiel, Tom, Fitz-Patrick, David, Fogarty, Charles M., Ford, Stacy, Forero, Lina M., Formentini, Elizabeth, Franco-Vitteri, Doris, Frenck, Robert W., Jr., Gharib, Elie, Gharib, Suzanne, Rucker, Rola G., Goldenberg, James N., González, Luis H., Gray, Brett, Greene, Rusty, Grossberg, Robert M., Guanira-Carranza, Juan V., Guerreros Benavides, Alfredo Gilberto, Guillory, Clint C., Gunaratne, Shauna H., Halpert, David, Hamilton, Holli, Hartman, William R., Henderson, Sheryl L., Herati, Ramin, Guarin, Laura Hernandez, Hilder, Robin, Ho, Ken, Hojat, Leila, Hosek, Sybil G., Jacobson, Jeffrey M., Jay, Melanie, Johnson, Diane H., Jones, Kathleen S., Jones-López, Edward C., Justman, Jessica E., Kahney, Scott, Katz, Lois, Katz, Melinda, Kaul, Daniel, Keefer, Michael C., Kennedy, Ashley, Knishinsky, Jennifer, Kogelman, Laura, Koletar, Susan L., Kottkamp, Angelica, Laguio-Vila, Maryrose, Landovitz, Raphael J., Lee, Jessica L., Liu, Albert, Llerena Zegarra, Eneyda Giuvanela, Lok, Anna S., Lovell, James, Lubelchek, Ronald, Lucaj, John, Luckasen, Gary, Luetkemeyer, Annie, Lugogo, Njira Lucia, Maenza, Janine, Malvestutto, Carlos, Mauri, Monica, Maves, Ryan C., Mayer, Kenneth H., McCartney, Michael J., McCort, Margaret E., McElrath, M. Juliana, McNairy, Meredith, Merino, Fernando L., Meyerowitz, Eric A., Mitchell, Carol L., Monaco, Cynthia L., Muhammad, Sauda, Muñoz-Gómez, Sigridh, Munsiff, Sonal, Nee, Paul, Nollen, Nicole L., Noor, Asif, Lagos, Claudio Nuñez, Okulicz, Jason F., Oliver, Patrick A., Ortega, Jessica, Palmer, Steven, Parameswaran, Lalitha, Parikh, Purvi, Parker, Susan, Parungao, Reza, Pavie, Juana R., Madan, Rebecca P., Peralta, Henry, Petts, Jennifer, Pierce, Kristen K., Pretell Alva, E. Javier, Purpura, Lawrence J., Raabe, Vanessa, Recuenco, Sergio E., Richards, Tamara, Riddler, Sharon A., Rizzardi, Barbara, Rokser, Rachel, Rolle, Charlotte-Paige, Rosen, Adam, Rosen, Jeffrey, Freese, Lena R., Santolaya, María E., Schipani, Linda M., Schwartz, Adam, Schwasinger-Schmidt, Tiffany, Scott, Hyman, Sha, Beverly E., Shankaran, Shivanjali, Shapiro, Adrienne E., Sharp, Stephan C., Shopsin, Bo, Sims, Matthew D., Skipper, Stephanie, Smith, Derek M., Smith, Michael J., Sobhanie, M. Mahdee, Sovic, Brit, Sterling, Stephanie, Striker, Robert, Tafur Bances, Karla Beatriz, Talaat, Kawsar R., Tavel, Edward M., Jr., Tieu, Hong V., Tomaszewski, Christian, Tomlinson, Ryan, Torres, Juan P., Torres, Julian A., Treanor, John J., Tukuru, Sade, Ulrich, Robert J., Utz, Gregory C., Viar, Veronica, Viau Colindres, Roberto A., Walsh, Edward E., Walsh, Mary C., Walter, Emmanuel B., Weidler, Jessica L., Wu, Yi H., Yang, Kinara S., Yrivarren Giorza, Juan Luis, Zemanek, Arthur L., Zhang, Kevin, Zingman, Barry S., Gorman, Richard, Paez, Carmen A., Swann, Edith, Takuva, Simbarashe G., Greninger, Alex, Roychoudhury, Pavitra, Coombs, Robert W., Jerome, Keith R., Castellino, Flora, Tong, Xiaomi, Pavetto, Corrina, Gipson, Teletha, Tong, Tina, Lee, Marina, Zhou, James, Fay, Michael, McQuarrie, Kelly, Nnadi, Chimeremma, Sogbetun, Obiageli, Ahmad, Nina, De Proost, Ian, Hoseyni, Cyrus, Coplan, Paul, Khan, Najat, Ronco, Peter, Furey, Dawn, Meck, Jodi, Vingerhoets, Johan, Brandenburg, Boerries, Custers, Jerome, Hendriks, Jenny, Juraszek, Jarek, Marit de Groot, Anne, Van Roey, Griet, Heerwegh, Dirk, Van Dromme, Ilse, Méndez Galván, Jorge F., Carrascal, Monica B., Duran, Adriana Sordo, Sanchez Guerrero, Laura Ruy, Gómora Madrid, Martha Cecilia, Barrat Hernández, Alejandro Quintín, Guizar, Sharzhaad Molina, González Estrada, Denisse Alejandra, Martínez Pérez, Silvano Omar, Zárate Hinojosa, Zindy Yazmín, Ruiz-Palacios, Guillermo Miguel, Cruz-Valdez, Aurelio, Pacheco-Flores, Janeth, Lara, Anyela, Díaz-Miralrio, Secia, Reyes Fentanes, María José, Olmos Vega, Jocelyn Zuleica, Méndez, Daniela Pineda, Martínez, Karina Cano, Alvarez León, Winniberg Stephany, Ruiz Herrera, Vida Veronica, Vázquez Saldaña, Eduardo Gabriel, Camacho Choza, Laura Julia, Vega Orozco, Karen Sofia, Ortega Domínguez, Sandra Janeth, Chacón, Jorge A., Rivera, Juan J., Cutz, Erika A., Ortegón, Maricruz E., Rivera, María I., Browder, David, Burch, Cortney, Moye, Terri, Bondy, Paul, Browder, Lesley, Manning, Rickey D., Hurst, James W., Sturgeon, Rodney E., Wakefield, Paul H., Kirby, John A., Andersen, James, Fearon, Szheckera, Negron, Rosa, Medina, Amy, Hill, John M., Rajasekhar, Vivek, Williams, Hayes, Cade, LaShondra, Fouts, Rhodna, Moya, Connie, Anderson, Corey G., Devine, Naomi, Ramsey, James, Perez, Ashley, Tatelbaum, David, Jacobs, Michael, Menasche, Kathleen, Mirkil, Vincent, Winkle, Peter J., Haggag, Amina Z., Haynes, Michelle, Villegas, Marysol, Raja, Sabina, Riesenberg, Robert, Plavin, Stanford, Lerman, Mark, Woodside, Leana, Johnson, Maria, Healy, C. Mary, Whitaker, Jennifer A., Keitel, Wendy A., Atmar, Robert L., Horwith, Gary, Mason, Robin, Johnson, Lisa, Dora, Tambra, Murray, Deborah, Ledbetter, Logan, Ewing, Beverly, Stephenson, Kathryn E., Tan, Chen S., Zash, Rebecca, Ansel, Jessica L., Jaegle, Kate, Guiney, Caitlin J., Henderson, Jeffrey A., O'Leary, Marcia, Enright, Kendra, Kessler, Jill, Ducheneaux, Pete, Inniss, Asha, Brandon, Donald M., Davis, William B., Lawler, Daniel T., Oppong, Yaa D., Starr, Ryan P., Syndergaard, Scott N., Shelly, Rozeli, Majumder, Mashrur Islam, Sugimoto, Danny, Dugas, Jeffrey, Sr., Rijos, Dolores, Shelton, Sandra, Hong, Stephan, Schwartz, Howard, Sanchez-Crespo, Nelia, Schwartz, Jennifer, Piedra, Terry, Corral, Barbara, Medina, Carmen, Dever, Michael E., Shah, Mitul, Delgado, Michael, Scott, Tameika, Usdan, Lisa S., McGill, Lora J., Arnold, Valerie K., Scatamacchia, Carolyn, Anthony, Codi M., Merchant, Rajan, Yoon, Anelgine C., Hill, Janet, Ng-Price, Lucy, Thompson-Seim, Teri, Ackerman, Ronald, Ackerman, Jamie, Aristy, Florida, Ketter, Nzeera, Finley, Jon, Stull, Mildred, Murray, Monica, Rizvi, Zainab, Guerrero, Sonia, Paliwal, Yogesh K., Paliwal, Amit, Gordon, Sarah, Gordon, Bryan, Montano-Pereira, Cynthia, Galloway, Christopher, Montros, Candice, Aleman, Lily, Shairi, Samira, Van Ever, Wesley, Freeman, George H., Harmon, Esther L., Cross, Marshall A., Sales, Kacie, Gular, Catherine Q., Hepburn, Matthew, Alderson, Nathan, Harshell, Shana, Mahgoub, Siham, Maxwell, Celia, Mellman, Thomas, Thompson, Karl M., Wortman, Glenn, Kingsley, Jeff, Pixler, April, Curry, LaKondria, Afework, Sarah, Swanson, Austin, Jacqmein, Jeffry, Bowers, Maggie, Robison, Dawn, Mosteller, Victoria, Garvey, Janet, Easley, Mary, Kurnat, Rebecca J., Cornelison, Raymond, Gower, Shanda, Schnitz, William, Heinzig-Cartwright, Destiny S., Lewis, Derek, Newton, Fred E., Duhart, Aeiress, Watkins, Breanz, Ball, Brandy, York, Jill, Pickle, Shelby, Musante, David B., Silver, William P., Belhorn, Linda R., Viens, Nicholas A., Dellaero, David, Patel, Priti, Lisec, Kendra, Safirstein, Beth, Zapata, Luz, Gonzalez, Lazaro, Quevedo, Evelyn, Irani, Farah, Grillo, Joseph, Potts, Amy, White, Julie, Flume, Patrick, Headden, Gary, Taylor, Brandie, Warden, Ashley, Chamberlain, Amy, Jeanfreau, Robert, Jeanfreau, Susan, Matherne, Paul G., Caldwell, Amy, Stahl, Jessica, Vowell, Mandy, Newhouse, Lauren, Berthaud, Vladimir, Takizala, Zudi-Mwak, Beninati, Genevieve, Snell, Kimberly, Baker, Sherrie, Walker, James, Harrison, Tavane, Miller, Meagan, Otto, Janet, Gray, Roni, Wilson, Christine, Nemecek, Tiffany, Harrington, Hannah, Eppenbach, Sally, Lewis, Wendell, Bourgeois, Tana, Folsom, Lyndsea, Holt, Gregory, Mirsaeidi, Mehdi, Calderon, Rafael, Lichtenberger, Paola, Quintero, Jalima, Martinez, Becky, Immergluck, Lilly, Johnson, Erica, Chan, Austin, Fas, Norberto, Thomas-Seaton, LaTeshia, Khizer, Saadia, Staben, Jonathan, Beresnev, Tatiana, Jahromi, Maryam, Marovich, Mary A., Hutter, Julia, Nason, Martha, Ledgerwood, Julie, Mascola, John, Leibowitz, Mark, Morales, Fernanda, Delgado, Mike, Sanchez, Rosario, Vega, Norma, Áñez, Germán, Albert, Gary, Coston, Erin, Desai, Chinar, Dunbar, Haoua, Eickhoff, Mark, Garcia, Jenina, Kautz, Margaret, Lee, Angela, Lewis, Maggie, McGarry, Alice, McKnight, Irene, Nelson, Joy, Newingham, Patrick, Price-Abbott, Patty, Reed, Patty, Vegas, Diana, Wilkinson, Bethanie, Smith, Katherine, Woo, Wayne, Cho, Iksung, Glenn, Gregory M., Dubovsky, Filip, Fried, David L., Haughey, Lynne A., Stanton, Ariana C., Rameaka, Lisa Stevens, Rosenberg, David, Tomatsu, Lee, Gonzalez, Viviana, Manalo, Millie, Grunstra, Bernard, Quinn, Donald, Claybrook, Phillip, Olds, Shelby, Dye, Amy, Cannon, Kevin D., Chadwick, Mesha M., Jordan, Bailey, Hussey, Morgan, Nevarez, Hannah, Kelley, Colleen F., Chung, Michael, Moran, Caitlin, Rebolledo, Paulina, Bacher, Christina, Barranco-Santana, Elizabeth, Rodriguez, Jessica, Mendoza, Rafael, Ruperto, Karen, Olivieri, Odette, Ocaña, Enrique, Wylie, Paul E., Henderson, Renea, Jenson, Natasa, Yang, Fan, Kelley, Amy, Finkelstein, Kenneth, Beckmann, David, Hutchins, Tanya, Escallon, Sebastian Garcia, Johnson, Kristen, Sligh, Teresa S., Desai, Parul, Huynh, Vincent, Lopez, Carlos, Mendoza, Erika, Adelglass, Jeffrey, Naifeh, Jerome G., Kucera, Kristine J., Chughtai, Waseem, Jaffer, Shireen H., Davis, Matthew G., Foley, Jennifer, Burgett, Michelle L., Shlotzhauer, Tammi L., Ingalsbe-Geno, Sarah M., Duncanson, Daniel, Kush, Kelly, Nesbitt, Lori, Sonnier, Cora, McCarter, Jennifer, Butcher, Michael B., Fry, James, Percy, Donna, Freudemann, Karen, Gebhardt, Bruce C., Mangu, Padma N., Schroeck, Debra B., Davit, Rajesh K., Hennekes, Gayle D., Luft, Benjamin J., Carr, Melissa, Nachman, Sharon, Pellecchia, Alison, Smith, Candace, Valenti, Bruno, Bermudez, Maria I., Peraita, Noris, Delgado, Ernesto, Arrazcaeta, Alicia, Ramirez, Natalie, Amador, Carmen, Marafioti, Horacio, Dang, Lyly, Clement, Lauren, Berry, Jennifer, Allaw, Mohammed, Geuss, Georgettea, Miles, Chelsea, Bittner, Zachary, Werne, Melody, Calinescu, Cornell, Rodman, Shannon, Rindt, Joshua, Cooksey, Erin, Harrison, Kristina, Cooper, Deanna, Horton, Manisha, Philyaw, Amanda, Jennings, William, Alvarado, Hilario, Baka, Michele, Regalado, Malina, Murray, Linda, Naguib, Sherif, Singletary, Justin, Richmond, Sha-Wanda, Omodele, Sarah, Oppenheim, Emily, Martinez, Reuben, Andriulis, Victoria, Singer, Leonard, Blevins, Jeanne, Thomas, Meagan, Hull, Christine, Pereira, Isabel, Rivero, Gina, Okonya, Tracy, Downing, Frances, Miller, Paulina, Rhee, Margaret, Stapleton, Katherine, Klein, Jeffrey, Hong, Rosamond, Swan, Suzanne, Wahlin, Tami, Bennett, Elizabeth, Salzl, Amy, Phan, Sharine, White, Jewel J., Occhino, Amanda, Paiano, Ruth, McLaughlin, Morgan, Swieboda, Elisa, Garcia-Fragoso, Veronica, Becerra, Maria G., White, Toni, Turley, Christine B., McWilliams, Andrew, Esinhart, Tiffany, Montoya, Natasha, Huskey, Shamika, Paul, Leena, Tashima, Karen, Johnson, Jennie, Neill, Marguerite, Sanchez, Martha, Rybak, Natasha, Mileno, Maria, Cohen, Stuart H., Ruiz, Monica, Boswell, Dean M., Robison, Elizabeth E., Reynolds, Trina L., Neumeister, Sonja, Zorrilla, Carmen D., Rivera, Juana, Ibarra, Jessica, García, Iris, Sierra, Dianca, Ramon, Wanda, Fiorillo, Suzanne, Pitotti, Rebecca, Anderson, Victoria R., Mancilla, Jose Castillo, Le, Nga, Winokur, Patricia L., Ince, Dilek, Hegmann, Theresa, Meier, Jeffrey, Stapleton, Jack, Stulken, Laura, McArthur, Monica, Berry, Andrea, Tapia, Milagritos, Hammershaimb, Elizabeth, Robinson, Toni, MacBryde, Rosa, Kline, Susan, Billings, Joanne L., Cavert, Winston, Forgosh, Les B., Schacker, Timothy W., Bold, Tyler D., Dandachi, Dima, Nelson, Taylor, Bran, Andres, Geiger, Grant, Naqvi, S. Hasan, Florescu, Diana F., Starlin, Richard, Kline, David, Zimmer, Andrea, Abbas, Anum, Wilson, Natasha, Eron, Joseph J., Sciaudone, Michael, Rosengren, A. Lina, Kizer, John S., Rutstein, Sarah E., Bruce, Elizabeth, Espinosa, Claudia, Sanders, Lisa J., Kim, Kami, Casey, Denise, Taylor, Barbara S., Patterson, Thomas, Pinilla, Ruth S., Bullock, Delia, Ponce, Philip, Patterson, Jan, McClelland, R. Scott, Lane, Dakotah C., Wald, Anna, James, Frank, Duke, Elizabeth, Hauge, Kirsten, Heimonen, Jessica, Goecker, Erin A., Huang, Yunda, Fong, Youyi, Kauffman, Carol, Linder, Kathleen, Nofz, Kimberly, McConnell, Andrew, Buynak, Robert J., Webb, Angella, Petty, Taryn, Andree, Stephanie, Sanchez, Erica, Mackey, Nolan, Baudelaire, Clarisse, Dzigiel, Sarah, Marquez, Adrienna, Quillin, Kim, King, Michelle, Abad, Vanessa, Knowles, Jennifer, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Tovar, Dalia, Shaw, Marian E., Turner, Mark A., Huffine, Cory J., Huffine, Esther S., Ake, Julie A., Secord, Elizabeth, McGrath, Eric, Levy, Phillip, Stewart, Brittany, Cromer, Charnell, Walters, Ayanna, Ellsworth, Grant, Greene, Caroline, Galloway, Sarah, Kapadia, Shashi, DeHaan, Elliot, Wilson, Clint, Milligan, Jason, Raley, Danielle, Bocchini, Joseph, McClenathan, Bruce, Hussain, Mary, Lomasney, Evelyn, Hall, Evelyn, Lamberth, Sherry, Schmeck, Christy, Leathers, Vickie, Theodore, Deborah A., Branche, Angela R., Graciaa, Daniel S., Hatlen, Timothy J., Miller, Jacqueline, Sadoff, Jerald, Falsey, Ann R., Sobieszczyk, Magdalena E., Rick, Anne-Marie, Laurens, Matthew B., Huang, Ying, Yu, Chenchen, Martin, Thomas C.S., Rodriguez, Carina A., Rostad, Christina A., Maboa, Rebone M., Baden, Lindsey R., El Sahly, Hana M., Grinsztejn, Beatriz, Gray, Glenda E., Gay, Cynthia L., Gilbert, Peter B., Janes, Holly E., Kublin, James G., Leav, Brett, Hirsch, Ian, Struyf, Frank, Dunkle, Lisa M., Neuzil, Kathleen M., Corey, Lawrence, Goepfert, Paul A., Follmann, Dean, and Kotloff, Karen L.
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- 2023
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15. Pre-Operative Predictors of Health-Related Quality of Life Two Years After Pediatric Epilepsy Surgery: A Prospective Cohort Study
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Rojulpote, Krishna Vamsi, Smith, Mary Lou, Puka, Klajdi, Speechley, Kathy N, Ferro, Mark A., Connolly, Mary B., Major, Philippe, Gallagher, Anne, Almubarak, Salah, Hasal, Simona, Ramachandrannair, Rajesh, Andrade, Andrea, Xu, Qi, Leung, Edward, Snead, O. Carter, III, and Widjaja, Elysa
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- 2023
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16. RAQUEL RABINOVICH
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Smith, Mary
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Painting -- Exhibitions ,Arts, visual and performing - Abstract
Avatars Hutchinson Modern & Contemporary, New York April 18-June 15, 2024 Looking at images of Raquel Rabinovich's Avatars on a screen in any reproductive format is to wrestle with the [...]
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- 2024
17. Evaluation of a Genetic Risk Score for Diagnosis of Psoriatic Arthritis
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Smith, Mary Patricia, Ly, Karen, Thibodeaux, Quinn, Beck, Kristen, Yang, Eric, Sanchez, Isabelle, Nititham, Joanne, Bhutani, Tina, and Liao, Wilson
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Prevention ,Autoimmune Disease ,Human Genome ,Clinical Research ,Psoriasis ,Arthritis ,Rare Diseases ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,blood tests ,diagnosis ,psoriasis ,psoriatic arthritis ,symptoms - Abstract
BackgroundDiagnosis of psoriatic arthritis (PsA) can be challenging, resulting in delays that contribute to irreversible joint damage, reduced quality of life, and increased mortality.ObjectiveUse genetic markers to develop and evaluate a PsA genetic risk score (GRS) for its ability to discriminate between psoriasis (PsO) only and PsO with PsA among a psoriatic cohort with full genome-wide genotype data.MethodsGenome-wide single-nucleotide polymorphism genotyping was performed on 724 psoriatic patients. A set of 11 candidate risk genes previously shown to be preferentially associated with PsO or PsA were selected. To evaluate the cumulative effects of these risk loci, a PsA GRS was developed using an unweighted risk allele count (cGRS) and a weighted (wGRS) approach. Additional analyses included only human leukocyte antigen (HLA) risk alleles.ResultsThe discriminative power attributable to each GRS was evaluated by calculating the areas under the receiver operator characteristic curve (AUROC). The AUROC for the wGRS is 56.2% versus 54.1% for the cGRS, and the AUROC for the HLA-only wGRS model was 56.9% versus 55.7% for the HLA-only cGRS.ConclusionThe AUROC of 56.9% for HLA-only wGRS indicates that this approach has the greatest power in discriminating PsA from PsO among these models. Given that an AUROC of 56.9% is quite modest, this study suggests that using a small number of well-validated genetic loci provides limited predictive power for PsA, and that future approaches may benefit from using a larger number of genetic loci.
- Published
- 2020
18. Implementation of an Ultraviolet Phototherapy Service at a National Referral Hospital in Western Kenya: Reflections on Challenges and Lessons Learned.
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Ly, Karen, Chang, Aileen Y, Kiprono, Samson K, Jose, Margareth, Smith, Mary Patricia, Beck, Kristen, Sekhon, Sahil, Muraguri, Isabel, Mungai, Margaret, Coates, Sarah J, Thibodeaux, Quinn, Hulse, Sarah, Gualberto, Marissa, Jeon, Caleb, Nakamura, Mio, Bhutani, Tina, Maurer, Toby, and Liao, Wilson
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Africa ,Dermatology ,Kenya ,Low- and middle-income countries ,Phototherapy ,Resource-limited settings ,UVB ,Ultraviolet light ,Low ,and middle-income countries ,Clinical Sciences - Abstract
IntroductionIn order to manage skin conditions at a national referral hospital level in Kenya, specialized dermatology services, such as dermatologic surgery, dermatopathology, phototherapy, and sub-specialty care, should be offered, as is typically available in referral hospitals around the world. A Kenyan patient with prurigo nodularis, whose severe itch remitted after phototherapy treatment at the University of California, San Francisco (UCSF), inspired the development of a phototherapy service at Academic Model Providing Access to Healthcare (AMPATH), a partnership in Western Kenya between Moi Teaching and Referral Hospital, Moi University College of Health Sciences, and a consortium of North American academic medical centers.MethodsInitial project funds were raised through a crowdfunding campaign and fundraising events. A new narrowband ultraviolet B phototherapy unit and replacement bulbs were donated and air shipped to Eldoret, Kenya. A team of dermatologists and phototherapy nurses from UCSF conducted a 2-day training session. US-based dermatologists affiliated with AMPATH provide ongoing support through regular communication and on-site visits.ResultsEarly in implementation, challenges faced included training clinical staff with limited experience in phototherapy and improving communication between nurses and clinicians. More recent challenges include frequent rotation of specialty clinic nurses in the dermatology clinic, adaptation of phototherapy guidelines to balance patient volume with service delivery capacity, and training assessment of disease activity in darkly pigmented skin.ConclusionStrategies that have been helpful in addressing implementation challenges include: increasing on-site and remote training opportunities for clinicians and nurses, developing a tiered payment schema, educating patients to combat misconceptions about phototherapy, dynamic phototherapy referral guidelines to accommodate service delivery capacity, and prioritizing the engagement of a multidisciplinary team.
- Published
- 2020
19. A spotlight on avoidance coping to manage fear of recurrence among breast cancer survivors in an eHealth intervention
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Hall, Daniel L., Levine, Beverly J., Jeter, Elizabeth, Chandler, Allison, Tooze, Janet A., Duffecy, Jenna, Victorson, David, Gradishar, William, Leach, Joseph, Saphner, Thomas, Smith, Mary Lou, Penedo, Frank, Mohr, David C., Cella, David, and Wagner, Lynne I.
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- 2022
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20. High-quality read-based phasing of cystic fibrosis cohort informs genetic understanding of disease modification
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Mastromatteo, Scott, Chen, Angela, Gong, Jiafen, Lin, Fan, Thiruvahindrapuram, Bhooma, Sung, Wilson W.L., Whitney, Joe, Wang, Zhuozhi, Patel, Rohan V., Keenan, Katherine, Halevy, Anat, Panjwani, Naim, Avolio, Julie, Wang, Cheng, Côté-Maurais, Guillaume, Bégin, Stéphanie, Adam, Damien, Brochiero, Emmanuelle, Bjornson, Candice, Chilvers, Mark, Price, April, Parkins, Michael, van Wylick, Richard, Mateos-Corral, Dimas, Hughes, Daniel, Smith, Mary Jane, Morrison, Nancy, Tullis, Elizabeth, Stephenson, Anne L., Wilcox, Pearce, Quon, Bradley S., Leung, Winnie M., Solomon, Melinda, Sun, Lei, Ratjen, Felix, and Strug, Lisa J.
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- 2023
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21. Automated enumeration of Eimeria oocysts in feces for rapid coccidiosis monitoring
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Smith, Mary K., Buhr, Diane L., Dhlakama, Thabani A., Dupraw, Diana, Fitz-Coy, Steve, Francisco, Alexandra, Ganesan, Arjun, Hubbard, Sue Ann, Nederlof, Andrew, Newman, Linnea J., Stoner, Matthew R., Teichmann, June, Voyta, John C., Wooster, Robert, Zeygerman, Alla, Zwilling, Matthew F., and Kiss, Margaret M.
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- 2023
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22. The Power of Convening: ABA's legacy and continued impact of convening minds and shaping progress
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Smith, Mary
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Conferences and conventions -- Evaluation ,Law ,American Bar Association -- History -- Services -- Evaluation -- Conferences, meetings and seminars - Abstract
In 1878, 75 visionary lawyers from 20 states gathered in Saratoga Springs, New York, driven by the pressing need for national cohesion in a decentralized legal landscape, marking the formation [...]
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- 2023
23. Providing microbiology education to rural nurses: A case study
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Castelletto, Kathryn, primary, Green, Elyce, additional, Seaman, Claire Ellen, additional, Ellis, Natalie, additional, Smith, Mary-Clare, additional, and Vanniasinkam, Thiru, additional
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- 2024
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24. Evaluating an equity-focused approach to assess climate resilience and disaster priorities through a community survey
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Lovell, Samantha, primary, Vickery, Jamie, additional, López, Paulina, additional, Rodríguez, Alberto J., additional, Cummings, B. J., additional, Moloney, Kathleen, additional, Berman, Jeffrey, additional, Bostrom, Ann, additional, Isaksen, Tania Busch, additional, Estrada, Erika, additional, Hartwell, Cat, additional, Kohler, Pamela, additional, Kramer, C. Bradley, additional, Patel, Resham, additional, Schnall, Amy Helene, additional, Smith, Mary Hannah, additional, and Errett, Nicole A., additional
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- 2024
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25. Validating a theory of planned behavior questionnaire for assessing changes in professional behaviors of medical students
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Guraya, Shaista Salman, primary, Clarke, Eric, additional, Sadeq, Asil, additional, Smith, Mary, additional, Hand, Sinead, additional, Doyle, Frank, additional, Kearney, Grainne, additional, Harbinson, Mark, additional, Ryan, Aine, additional, Boland, Fiona, additional, Bensaaud, Abdelsalam, additional, Guraya, Salman Yousuf, additional, and Harkin, Denis W., additional
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- 2024
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26. Dual biologic therapy for recalcitrant psoriasis and psoriatic arthritis.
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Thibodeaux, Quinn, Ly, Karen, Reddy, Vidhatha, Smith, Mary Patricia, and Liao, Wilson
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TNF ,tumor necrosis factor ,combined biologic therapy ,dual biologic therapy ,psoriasis ,psoriatic arthritis - Published
- 2019
27. A review of dupilumab in the treatment of atopic diseases
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Thibodeaux, Quinn, Smith, Mary Patricia, Ly, Karen, Beck, Kristen, Liao, Wilson, and Bhutani, Tina
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Lung ,Biotechnology ,Asthma ,Prevention ,Evaluation of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Inflammatory and immune system ,Respiratory ,Skin ,Good Health and Well Being ,Antibodies ,Monoclonal ,Humanized ,Clinical Trials as Topic ,Dermatitis ,Atopic ,Drug Therapy ,Combination ,Eczema ,Humans ,Injections ,Subcutaneous ,Severity of Illness Index ,Treatment Outcome ,United States ,United States Food and Drug Administration ,Dupilumab ,Dupixent ,atopic dermatitis ,eczema ,asthma ,IL-4 ,IL-13 ,biologic ,review ,Immunology ,Medical Microbiology ,Pharmacology and Pharmaceutical Sciences ,Virology - Abstract
Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important drivers of atopic diseases. In March of 2017, the United States Food and Drug Administration (FDA) approved dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults that is uncontrolled with topical medications, becoming the first biologic agent approved to treat this chronic skin condition. In October of 2018, Dupilumab received approval by the FDA as an add-on maintenance therapy in patients with moderate-to-severe asthma aged 12 years or older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma. This review summarizes the characteristics of dupilumab and the clinical research that has been published to date, including treatment efficacy and adverse events.
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- 2019
28. Factors Influencing Sleep Difficulty and Sleep Quantity in the Citizen Pscientist Psoriatic Cohort
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Smith, Mary Patricia, Ly, Karen, Thibodeaux, Quinn, Weerasinghe, Thulasi, Beck, Kristen, Shankle, Lindsey, Armstrong, April W, Boas, Marc, Bridges, Alisha, Doris, Frank, Gelfand, Joel M, Lafoy, Brian, Orbai, Ana-Maria, Takeshita, Junko, Truman, Sarah, Wan, Marilyn T, Wu, Jashin J, Siegel, Michael P, Bell, Stacie J, Bhutani, Tina, and Liao, Wilson
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Lung ,Arthritis ,Autoimmune Disease ,Neurosciences ,Obesity ,Sleep Research ,Clinical Research ,Psoriasis ,Good Health and Well Being ,Comorbidities ,Sleep ,Survey research ,Clinical Sciences - Abstract
IntroductionSleep is essential for overall health and well-being, yet more than one-third of adults report inadequate sleep. The prevalence is higher among people with psoriasis, with up to 85.4% of the psoriatic population reporting sleep disruption. Poor sleep among psoriasis patients is particularly concerning because psoriasis is independently associated with many of the same comorbidities as sleep dysfunction, including cardiovascular disease, obesity, and depression. Given the high prevalence and serious consequences of disordered sleep in psoriasis, it is vital to understand the nature of sleep disturbance in this population. This study was designed to help meet this need by using survey data from Citizen Pscientist, an online patient portal developed by the National Psoriasis Foundation.MethodsOur analysis included 3118 participants who identified as having a diagnosis by a physician of psoriasis alone or psoriasis with psoriatic arthritis. Demographic information, psoriasis severity and duration, sleep apnea status, smoking and alcohol consumption, itch timing, and sleep characteristics were included. Two separate multivariate logistic regression models in STATA were used to determine whether the presence of psoriatic arthritis, age, gender, body mass index, comorbid sleep apnea, psoriasis severity, timing of worst itch, smoking status, or high-risk alcohol consumption were associated with sleep difficulty or low sleep quantity, defined by the American Academy of Sleep Medicine as less than 7 h of sleep per night on average.ResultsResults from the multivariate logistic regressions found that sleep difficulty was associated with psoriatic arthritis (OR 2.15, 95% CI [1.79-2.58]), female gender (2.03 [1.67-2.46]), obese body mass index (BMI ≥ 30) (1.25 [1.00-1.56]), sleep apnea (1.41 [1.07-1.86]), psoriasis severity of moderate (1.59 [1.30-1.94]) or severe (2.40 [1.87-3.08]), and smoking (1.60 [1.26-2.02]). Low sleep quantity was associated with obese BMI (1.62 [1.29-2.03]), sleep apnea (1.30 [1.01-1.68]), psoriasis severity of moderate (1.41 [1.16-1.72]) or severe (1.40 [1.11-1.76]), and smoking (1.62 [1.31-2.00]). Sleep difficulty and low sleep quantity were not associated with age, alcohol consumption, or timing of worst itch.ConclusionThese results are potentially meaningful in several aspects. We identify an important distinction between sleep difficulty and sleep quantity in psoriatic disease, whereby having psoriatic arthritis and being female are each associated with sleep difficulty despite no association with low sleep quantity. Furthermore, there is conflicting evidence from prior studies as to whether psoriasis severity is associated with sleep difficulty, but this well-powered, large study revealed a strong, graded relationship between psoriasis severity and both sleep difficulty and low sleep quantity. Overall, our results show that both sleep difficulty and low sleep quantity were associated with multiple factors in this analysis of a large psoriatic cohort. These findings suggest that dermatologists may gather clinically useful information by screening psoriatic patients for trouble sleeping and low sleep quantity to identify potential comorbidities and to more effectively guide disease management.
- Published
- 2019
29. Emerging Methods to Objectively Assess Pruritus in Atopic Dermatitis
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Smith, Mary Patricia, Ly, Karen, Thibodeaux, Quinn, Weerasinghe, Thulasi, Wu, Jashin J, Yosipovitch, Gil, Bhutani, Tina, and Liao, Wilson
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Neurosciences ,Behavioral and Social Science ,Clinical Research ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Atopic dermatitis ,Diagnosis ,Eczema ,Itch ,Pruritus ,Clinical Sciences - Abstract
INTRODUCTION:Atopic dermatitis (AD) is an inflammatory skin disease with a chronic, relapsing course. Clinical features of AD vary by age, duration, and severity but can include papules, vesicles, erythema, exudate, xerosis, scaling, and lichenification. However, the most defining and universal symptom of AD is pruritus. Pruritus or itch, defined as an unpleasant urge to scratch, is problematic for many reasons, particularly its negative impact on quality of life. Despite the profoundly negative impact of pruritus on patients with AD, clinicians and researchers lack standardized and validated methods to objectively measure pruritus. The purpose of this review is to discuss emerging methods to assess pruritus in AD by describing objective patient-centered tools developed or enhanced over the last decade that can be utilized by clinicians and researchers alike. METHODS:This review is based on a literature search in Medline, Embase, and Web of Science databases. The search was performed in February 2019. The keywords were used "pruritus," "itch," "atopic dermatitis," "eczema," "measurements," "tools," "instruments," "accelerometer," "wrist actigraphy," "smartwatch," "transducer," "vibration," "brain mapping," "magnetic resonance imaging," and "positron emission tomography." Only articles written in English were included, and no restrictions were set on study type. To focus on emerging methods, prioritization was given to results from the last decade (2009-2019). RESULTS:The search yielded 49 results in PubMed, 134 results in Embase, and 85 results in Web of Science. Each result was independently reviewed in a standardized manner by two of the authors (M.S., K.L.), and disagreements between reviewers were resolved by consensus. Relevant findings were categorized into the following sections: video surveillance, acoustic surveillance, wrist actigraphy, smart devices, vibration transducers, and neurological imaging. Examples are provided along with descriptions of how each technology works, instances of use in research or clinical practice, and as applicable, reports of validation studies and correlation with other methods. CONCLUSION:The variety of new and improved methods to evaluate pruritus in AD is welcomed by clinicians, researchers, and patients alike. Future directions include next-generation smart devices as well as exploring new territories, such as identifying biomarkers that correlate to itch and machine-learning programs to identify itch processing in the brain. As these efforts continue, it will be essential to remain patient-centered by developing techniques that minimize discomfort, respect privacy, and provide accurate data that can be used to better manage itch in AD.
- Published
- 2019
30. Dupilumab in patients with chronic hepatitis B on concomitant entecavir.
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Ly, Karen, Smith, Mary Patricia, Thibodeaux, Quinn, Beck, Kristen, Bhutani, Tina, and Liao, Wilson
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AD ,Atopic Dermatitis ,Dupixent ,HBV ,Hepatitis B Virus ,IL ,interleukin ,atopic dermatitis ,biologic ,dupilumab ,hepatitis B virus - Published
- 2019
31. Dupilumab for the treatment of severe photodermatitis.
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Smith, Mary Patricia, Ly, Karen, Thibodeaux, Quinn, Beck, Kristen, Berger, Timothy, Khodosh, Rita, Liao, Wilson, and Bhutani, Tina
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atopic dermatitis ,biologics ,photodermatitis ,therapy - Published
- 2019
32. Acrodermatitis continua of Hallopeau: clinical perspectives
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Smith, Mary Patricia, Ly, Karen, Thibodeaux, Quinn, Bhutani, Tina, Liao, Wilson, and Beck, Kristen M
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Clinical Trials and Supportive Activities ,Clinical Research ,Good Health and Well Being ,acrodermatitis continua of Hallopeau ,psoriasis ,pustular psoriasis ,generalized pustular psoriasis ,palmoplantar pustulosis - Abstract
Acrodermatitis continua of Hallopeau (ACH) is a rare, sterile pustular eruption of one or more digits. The condition presents with tender pustules and underlying erythema on the tip of a digit, more frequently arising on a finger than a toe. As far as classification, ACH is considered a localized form of pustular psoriasis. The eruption typically occurs after local trauma or infection, but such a history is not always present and various other etiologies have been described including infectious, neural, inflammatory, and genetic causes. The natural progression of ACH is chronic and progressive, often resulting in irreversible complications such as onychodystrophy that can result in anonychia, as well as osteitis that can result in osteolysis of the distal phalanges. Because of the rarity of ACH, there have been no randomized controlled studies to evaluate therapies, resulting in an absence of standardized treatment guidelines. In clinical practice, a wide variety of treatments have been attempted, with outcomes ranging from recalcitrance to complete resolution. In recent years, the introduction of biologics has provided a new class of therapy that has revolutionized the treatment of ACH. Specifically, rapid and sustained responses have been reported with the use of anti-tumor necrosis factor agents like infliximab, adalimumab, and etanercept; IL-17 inhibitors like secukinumab; IL-12/23 inhibitors like ustekinumab; and IL-1 inhibitors like anakinra. Nevertheless, there remains a considerable need for more research into treatment for the benefit of individual patients with ACH as well as for the clinical knowledge gained by such efforts. The purpose of this review is to provide a comprehensive overview of the key features of ACH as well as a discussion of clinical management strategies for this unique and debilitating condition.
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- 2019
33. Tofacitinib in the management of active psoriatic arthritis: patient selection and perspectives
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Ly, Karen, Beck, Kristen M, Smith, Mary P, Orbai, Ana-Maria, and Liao, Wilson
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Clinical Research ,Arthritis ,Aging ,Autoimmune Disease ,Psoriasis ,Rare Diseases ,Inflammatory and immune system ,tofacitinib ,psoriatic arthritis ,janus kinase ,kinase inhibitors - Abstract
Tofacitinib is an oral Janus kinase inhibitor approved for the treatment of psoriatic arthritis (PsA). It provides an alternative option for patients who have had an inadequate response and tolerance to other disease modifying antirheumatic drugs (DMARDs). It has demonstrated comparable efficacy to biologics, is effective in the management of treatment resistant disease, and is reported to improve enthesitis, dactylitis, and radiographic progression. Tofacitinib is also associated with an increased risk of serious infections, malignancy, and laboratory abnormalities. There is currently a large armamentarium of therapies for psoriatic arthritis, and choosing among treatments can be challenging. Due to this wide selection, a thorough assessment of psoriatic disease phenotype, patient preference, disease presentation, and comorbidities is critical. This review addresses key considerations in patient selection for the treatment of PsA with tofacitinib.
- Published
- 2019
34. Follicular spicules of multiple myeloma
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Smith, Mary Patricia and Manabat-Hidalgo, Catherine
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hyperkeratosis ,follicular spicules ,multiple myeloma ,paraneoplastic ,malignancy - Abstract
Follicular spicules are a very rare but highly characteristic cutaneous manifestation of multiple myeloma. The spicules typically appear as hyperkeratotic horns in the follicular openings of the face, most commonly on or around the nose and forehead. The pathophysiology of this condition has not been fully elucidated and remains an active area of research and debate. Herein we describe a patient who presented with follicular spicules in the context of unintentional weight loss, anemia, and elevated inflammatory markers. We discuss the diagnostic work-up for such a presentation, review the classification of follicular spicules of multiple myeloma, and describe approaches to manage this uncommon skin condition.
- Published
- 2019
35. Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease
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Gong, Jiafen, He, Gengming, Wang, Cheng, Bartlett, Claire, Panjwani, Naim, Mastromatteo, Scott, Lin, Fan, Keenan, Katherine, Avolio, Julie, Halevy, Anat, Shaw, Michelle, Esmaeili, Mohsen, Côté-Maurais, Guillaume, Adam, Damien, Bégin, Stéphanie, Bjornson, Candice, Chilvers, Mark, Reisman, Joe, Price, April, Parkins, Michael, van Wylick, Richard, Berthiaume, Yves, Bilodeau, Lara, Mateos-Corral, Dimas, Hughes, Daniel, Smith, Mary J., Morrison, Nancy, Brusky, Janna, Tullis, Elizabeth, Stephenson, Anne L., Quon, Bradley S., Wilcox, Pearce, Leung, Winnie M., Solomon, Melinda, Sun, Lei, Brochiero, Emmanuelle, Moraes, Theo J., Gonska, Tanja, Ratjen, Felix, Rommens, Johanna M., and Strug, Lisa J.
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- 2022
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36. Facilitators and barriers to reducing chemotherapy for early-stage breast cancer: a qualitative analysis of interviews with patients and patient advocates
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Andrews, Courtney, Childers, Timothy C., Wiseman, Kimberly D., Lawhon, Valerie, Ingram, Stacey, Smith, Mary Lou, Wolff, Antonio C., Wagner, Lynne, and Rocque, Gabrielle B.
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- 2022
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37. Advocate-BREAST: advocates and patients' advice to enhance breast cancer care delivery, patient experience and patient centered research by 2025.
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O'Sullivan, Ciara C., Larson, Nicole L., Vierkant, Robert A., Smith, Mary Lou, Chauhan, Cynthia, Couch, Fergus J., Olson, Janet E., Loprinzi, Charles L., and Ruddy, Kathryn J.
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METASTATIC breast cancer ,PATIENT experience ,PATIENTS' attitudes ,BREAST cancer ,HOT flashes - Abstract
Purpose: The aims of the Advocate-BREAST project are to study and improve the breast cancer (BC) patient experience through education and patient-centered research. Methods: In December 2021, an electronic REDCap survey was circulated to 6,918 BC survivors (stage 0–4) enrolled in the Mayo Clinic Breast Disease Registry. The questionnaire asked about satisfaction with BC care delivery, and education and support receive(d) regarding BC linked concerns. Patients also ranked Quality Improvement (QI) proposals. Results: The survey received 2,437 responses. 18% had Ductal Carcinoma in Situ, 81% had early breast cancer (EBC), i.e. stage 1–3, and 2% had metastatic breast cancer (MBC). Mean age was 64 (SD 11.8), and mean time since diagnosis was 93 months (SD 70.2). 69.3% of patients received all care at Mayo Clinic. The overall experience of care was good (> 90%). The main severe symptoms recalled in year 1 were alopecia, eyebrow/eyelash thinning, hot flashes, sexual dysfunction, and cognitive issues. The main concerns recalled were fear of BC recurrence/spread; loved ones coping; fear of dying, and emotional health. Patients were most dissatisfied with information regarding sexual dysfunction, eyebrow/eyelash thinning, peripheral neuropathy, and on side effects of immunotherapy/targeted therapies. Top ranking QI projects were: i) Lifetime access to concise educational resources; ii) Holistic support programs for MBC and iii) Wellness Programs for EBC and MBC. Conclusions: Patients with early and advanced BC desire psychological support, concise educational resources, and holistic care. Implications: Focused research and QI initiatives in these areas will improve the BC patient experience. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Data to Action: Community-Based Participatory Research to Address Concerns about Metal Air Pollution in Overburdened Neighborhoods near Metal Recycling Facilities in Houston
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Symanski, Elaine, Han, Heyreoun An, McCurdy, Sheryl, Hopkins, Loren, Flores, Juan, Han, Inkyu, Smith, Mary Ann, Caldwell, James, Fontenot, Cecelia, Wyatt, Bobbie, and Markham, Christine
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Houston, Texas -- Environmental aspects -- Health aspects ,Environmental health -- Research ,Micropollutants -- Health aspects -- Research ,Participant observation -- Usage ,Air pollution -- Causes of -- Health aspects ,Environmental issues ,Health - Abstract
Background: Exposures to environmental contaminants can be influenced by social determinants of health. As a result, persons living in socially disadvantaged communities may experience disproportionate health risks from environmental exposures. Mixed methods research can be used to understand community-level and individual-level exposures to chemical and nonchemical stressors contributing to environmental health disparities. Furthermore, community-based participatory research (CBPR) approaches can lead to more effective interventions. Objectives: We applied mixed methods to identify environmental health perceptions and needs among metal recyclers and residents living in disadvantaged neighborhoods near metal recycling facilities in Houston, Texas, in a CBPR study, Metal Air Pollution Partnership Solutions (MAPPS). Informed by what we learned and our previous findings from cancer and noncancer risk assessments of metal air pollution in these neighborhoods, we developed an action plan to lower metal aerosol emissions from metal recycling facilities and enhance community capacity to address environmental health risks. Methods: Key informant interviews, focus groups, and community surveys were used to identify environmental health concerns of residents. A diverse group from academia, an environmental justice advocacy group, the community, the metal recycling industry, and the local health department collaborated and translated these findings, along with results from our prior risk assessments, to inform a multifaceted public health action plan. Results: An evidence-based approach was used to develop and implement neighborhood-specific action plans. Plans included a voluntary framework of technical and administrative controls to reduce metal emissions in the metal recycling facilities, direct lines of communication among residents, metal recyclers, and local health department officials, and environmental health leadership training. Discussion: Using a CBPR approach, health risk assessment findings based on outdoor air monitoring campaigns and community survey results informed a multipronged environmental health action plan to mitigate health risks associated with metal air pollution. https://doi.org/10.1289/EHP11405, Introduction Communities of color bear higher burdens of chemical exposures, (1-4) which are due in part to the proximity of their neighborhoods to key exposure sources, including hazardous waste sites [...]
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- 2023
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39. A Deficit of Trust: ABA task force seeks to bolster public confidence in our institutions
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Smith, Mary
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United States. Supreme Court -- Public opinion -- Ethical aspects ,Public institutions -- Public opinion -- Ethical aspects ,Judicial ethics -- Laws, regulations and rules ,Trust (Psychology) -- Political aspects -- Management ,Government regulation ,Company business management ,Law ,American Bar Association -- Standards - Abstract
'A law repugnant to the Constitution is void.' --Chief Justice John Marshall For over two centuries, the principle of judicial review has been critical to the equilibrium of the federal [...]
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- 2023
40. Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda.
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Katrak, Shereen, Murphy, Maxwell, Nayebare, Patience, Rek, John, Smith, Mary, Arinaitwe, Emmanuel, Nankabirwa, Joaniter I, Kamya, Moses, Dorsey, Grant, Rosenthal, Philip J, and Greenhouse, Bryan
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Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Malaria ,Rare Diseases ,Infectious Diseases ,Vector-Borne Diseases ,Clinical Research ,4.1 Discovery and preclinical testing of markers and technologies ,4.2 Evaluation of markers and technologies ,Infection ,Good Health and Well Being ,Adult ,Child ,Child ,Preschool ,Cross-Sectional Studies ,DNA ,Protozoan ,Female ,Humans ,Infant ,Malaria ,Falciparum ,Male ,Middle Aged ,Molecular Diagnostic Techniques ,Nucleic Acid Amplification Techniques ,Plasmodium falciparum ,Prevalence ,Sensitivity and Specificity ,Uganda ,Medical and Health Sciences ,Tropical Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
Accurately identifying and targeting the human reservoir of malaria parasitemia is critical for malaria control, and requires a reliable and sensitive diagnostic method. Loop-mediated isothermal amplification (LAMP) is increasingly used to diagnose submicroscopic parasitemia. Although most published studies report the sensitivity of LAMP compared with nested polymerase chain reaction (PCR) as ≥ 80%, they have failed to use a consistent, sensitive diagnostic as a comparator. We used cross-sectional samples from children and adults in Tororo, Uganda, a region with high but declining transmission due to indoor residual spraying, to characterize the sensitivity and specificity of pan-Plasmodium LAMP for detecting submicroscopic infections. We compared LAMP results targeting a mitochondrial DNA sequence conserved in all Plasmodium species, performed on DNA extracted from dried blood spots, to those of a gold standard quantitative PCR assay targeting the var gene acidic terminal sequence of Plasmodium falciparum (varATS qPCR), performed on DNA extracted from 200 µL of whole blood. Using LAMP and varATS qPCR increased the detection of parasitemia 2- to 5-fold, compared with microscopy. Among microscopy-negative samples, the sensitivity of LAMP was 81.5% for detecting infection ≥ 1 parasites/µL. However, low density infections were common, and LAMP failed to identify more than half of all infections diagnosed by varATS qPCR, performing with an overall sensitivity of 44.7% for detecting submicroscopic infections ≥ 0.01 parasites/µL. Thus, although the LAMP assay is more sensitive than microscopy, it missed a significant portion of the submicroscopic reservoir. These findings have important implications for malaria control, particularly in settings where low-density infections predominate.
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- 2017
41. Patient-Reported Adverse Events and Early Treatment Discontinuation Among Patients With Multiple Myeloma
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Peipert, John Devin, primary, Zhao, Fengmin, additional, Lee, Ju-Whei, additional, Shen, Shu-en, additional, Ip, Edward, additional, O’Connell, Nathaniel, additional, Carlos, Ruth C., additional, Graham, Noah, additional, Smith, Mary Lou, additional, Gareen, Ilana F., additional, Raper, Pamela J., additional, Weiss, Matthias, additional, Kumar, Shaji K., additional, Rajkumar, S. Vincent, additional, Cella, David, additional, Gray, Robert, additional, and Wagner, Lynne I., additional
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- 2024
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42. “Electronic Phenotyping” Antimicrobials to Facilitate Outpatient Stewardship for Asymptomatic Bacteriuria and Urinary Tract Infection in Renal Transplant
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Zimmet, Alex N, primary, Ha, David, additional, Mui, Emily, additional, Smith, Mary, additional, Hawkins, Marten, additional, Alegria, William, additional, and Holubar, Marisa, additional
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- 2024
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43. Nature of the evidence base and approaches to guide nutrition interventions for individuals: a position paper from the Academy of Nutrition Sciences
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Hickson, Mary, primary, Papoutsakis, Constantina, additional, Madden, Angela M, additional, Smith, Mary Anne, additional, and Whelan, Kevin, additional
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- 2024
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44. Furthering Cultural Safety in Kidney Care Within Indigenous Communities: A Systematic and Narrative Review
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Smith, Mary, Silva e Silva, Vanessa, Schick-Makaroff, Kara, Kappel, Joanne, Bachynski, Jovina Concepcion, Monague, Valerie, Paré, Geneviève C., and Ross-White, Amanda
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- 2021
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45. Wabishki Bizhiko Skaanj: a learning pathway to foster better Indigenous cultural competence in Canadian health research
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Robinson-Settee, Helen, Settee, Craig, King, Malcolm, Beaucage, Mary, Smith, Mary, Desjarlais, Arlene, Chiu, Helen Hoi-Lun, Turner, Catherine, Kappel, Joanne, and McGavock, Jonathon M.
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- 2021
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46. Cystic fibrosis–related diabetes onset can be predicted using biomarkers measured at birth
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Lin, Yu-Chung, Keenan, Katherine, Gong, Jiafen, Panjwani, Naim, Avolio, Julie, Lin, Fan, Adam, Damien, Barrett, Paula, Bégin, Stéphanie, Berthiaume, Yves, Bilodeau, Lara, Bjornson, Candice, Brusky, Janna, Burgess, Caroline, Chilvers, Mark, Consunji-Araneta, Raquel, Côté-Maurais, Guillaume, Dale, Andrea, Donnelly, Christine, Fairservice, Lori, Griffin, Katie, Henderson, Natalie, Hillaby, Angela, Hughes, Daniel, Iqbal, Shaikh, Itterman, Jennifer, Jackson, Mary, Karlsen, Emma, Kosteniuk, Lorna, Lazosky, Lynda, Leung, Winnie, Levesque, Valerie, Maille, Émilie, Mateos-Corral, Dimas, McMahon, Vanessa, Merjaneh, Mays, Morrison, Nancy, Parkins, Michael, Pike, Jennifer, Price, April, Quon, Bradley S., Reisman, Joe, Smith, Clare, Smith, Mary Jane, Vadeboncoeur, Nathalie, Veniott, Danny, Viczko, Terry, Wilcox, Pearce, van Wylick, Richard, Cutting, Garry, Tullis, Elizabeth, Ratjen, Felix, Rommens, Johanna M., Sun, Lei, Solomon, Melinda, Stephenson, Anne L., Brochiero, Emmanuelle, Blackman, Scott, Corvol, Harriet, and Strug, Lisa J.
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- 2021
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47. Advocate-BREAST80+: A Comprehensive Patient and Advocate-Led Study to Enhance Breast Cancer Care Delivery and Patient-Centered Research in Women Aged ≥80 Years.
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O'Sullivan, Ciara C., Vierkant, Robert A., Larson, Nicole L., Smith, Mary Lou, Chauhan, Cynthia, Couch, Fergus J., Olson, Janet E., D'Andre, Stacy, Jatoi, Aminah, and Ruddy, Kathryn J.
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BREAST tumor treatment ,PATIENT education ,PSYCHOLOGICAL distress ,RESEARCH funding ,BREAST tumors ,CLINICAL medicine research ,MEDICAL care ,INTERVIEWING ,DECISION making ,DESCRIPTIVE statistics ,CANCER patients ,SYMPTOMS ,PATIENT-centered care ,SURVEYS ,WOMEN'S health ,NEEDS assessment ,PATIENT satisfaction ,SELF advocacy - Abstract
Simple Summary: The high-level aims of the Advocate-BREAST initiative are to study and improve the overall experience of patients with breast cancer (BC) through education, shared decision making, and patient-centered clinical trials. Advocate-BREAST80+ is a survey substudy that specifically focused on the unique needs and perspectives of BC patients aged ≥80 years. Although patients aged ≥80 years experienced less anxiety and symptom-related distress compared with younger patients, they were significantly less satisfied with information regarding short and long term side effects of BC therapies, as well as the management of same. Older patients were significantly less likely to have participated in a clinical trial or be open to considering this option in future. Future research should address unique educational needs and barriers to research participation in older BC patients. Focused interviews could assist with better comprehension of the lived experience of these patients, given the smaller number of BC patients ≥80 years in many available databases. Background: There are limited evidence-based data to guide treatment recommendations for breast cancer (BC) patients ≥80 years (P80+). Identifying and addressing unmet needs are critical. Aims: Advocate-BREAST80+ compared the needs of P80+ vs. patients < 80 years (P80−). Methods: In 12/2021, a REDCap survey was electronically circulated to 6918 persons enrolled in the Mayo Clinic Breast Disease Registry. The survey asked about concerns and satisfaction with multiple aspects of BC care. Results: Overall, 2437 participants responded (35% response rate); 202 (8.3%) were P80+. P80+ were less likely to undergo local regional and systemic therapies vs. P80− (p < 0.01). Notably, P80+ were significantly less satisfied with information about the short and long-term side effects of BC therapies and managing toxicities. P80+ were also less likely to have participated in a clinical trial (p < 0.001) or to want to do so in the future (p = 0.0001). Conclusions: Although P80+ experienced less anxiety and symptom-related distress compared with P80−, they were significantly less satisfied with information regarding the side effects of BC therapies and their management. P80+ were significantly less likely to have participated in a clinical trial or be open to considering this option. Future studies should address educational needs pertaining to side effects and barriers to research participation in P80+. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Use of Personality Frameworks in Health Science Education
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Childs-Kean, Lindsey, Edwards, Mary, and Smith, Mary Douglass
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- 2020
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49. Use of Learning Style Frameworks in Health Science Education
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Childs-Kean, Lindsey, Edwards, Mary, and Smith, Mary Douglass
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- 2020
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50. A Paradigm Shift in US Experiential Pharmacy Education Accelerated by the COVID-19 Pandemic
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Fuller, Kathryn A., Heldenbrand, Seth D., Smith, Mary Douglass, and Malcom, Daniel R.
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- 2020
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