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2. A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2022

Author

Barfield, Reagan K, primary, Brown, Matthew L, additional, Albrecht, Benjamin, additional, Barber, Katie E, additional, Bouchard, Jeannette, additional, Carr, Amy L, additional, Chahine, Elias B, additional, Cluck, David, additional, Covington, Elizabeth W, additional, Deri, Connor R, additional, Durham, Spencer H, additional, Faulkner-Fennell, Carmen, additional, Freeman, Lauren K, additional, Gauthier, Timothy P, additional, Gibson, Geneen M, additional, Green, Sarah B, additional, Hobbs, Athena L V, additional, Jones, Bruce M, additional, Jozefczyk, Caroline C, additional, Marx, Ashley H, additional, McGee, Edoabasi U, additional, McKamey, Lacie J, additional, Musgrove, Rachel, additional, Perez, Emily, additional, Slain, Douglas, additional, Stover, Kayla R, additional, Turner, Michelle S, additional, White, Cyle, additional, Bookstaver, P Brandon, additional, and Bland, Christopher M, additional

Published
2024
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3. The prevalence of gram-negative bacteria with difficult-to-treat resistance and utilization of novel β-lactam antibiotics in the southeastern United States

Author

Tsai, Y. Vivian, primary, Bookstaver, P. Brandon, additional, Kohn, Joseph, additional, Justo, Julie Ann, additional, Childress, Darrell, additional, Stramel, Stefanie, additional, Slain, Douglas, additional, Tu, Patrick, additional, Wingler, Mary Joyce B., additional, Jones, Bruce M., additional, Anderson, Daniel T., additional, Seddon, Megan M., additional, Cretella, David A., additional, Eudy, Joshua, additional, Winders, Hana, additional, Antosz, Kayla, additional, Bailey, Pamela, additional, and Al-Hasan, Majdi N., additional

Published
2024
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6. Ceftriaxone Versus Cefazolin Susceptibility as a Surrogate Marker for Cefpodoxime Susceptibility in Enterobacterales.

Author

Lambert, Kaitlyn V, Demkowicz, Ryan, Murray, Amanda, Howard, Catessa, and Slain, Douglas

Subjects
BIOMARKERS, ANTIMICROBIAL stewardship, CEFTRIAXONE, CEFAZOLIN, PATHOLOGICAL laboratories
Abstract

The Clinical and Laboratory Standards Institute stated that cefpodoxime susceptibility among Enterobacterales can be inferred from cefazolin, but this may overcall cefpodoxime resistance. We report a categorical agreement rate of 64% for cefazolin and 97% for ceftriaxone with cefpodoxime (P =.0001). Ceftriaxone appears to be a more useful cefpodoxime surrogate. [ABSTRACT FROM AUTHOR]

Published
2024
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8. 408. Benchmarking the Use of New β-lactams Utilizing a Novel Metric of Microbiological Burden

Author

Vivian Tsai, Y, primary, Brandon Bookstaver, P, additional, Kohn, Joseph, additional, Justo, Julie Ann, additional, Childress, Darrell, additional, Stramel, Stefanie, additional, Slain, Douglas, additional, Tu, Patrick, additional, Wingler, Mary Joyce B, additional, Jones, Bruce M, additional, Anderson, Daniel, additional, Seddon, Megan M, additional, Gibson, Geneen, additional, Cretella, David A, additional, Eudy, Joshua, additional, Winders, Hana R, additional, Antosz, Kayla, additional, Bailey, Pamela, additional, and Al-Hasan, Majdi N, additional

Published
2022
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10. 409. Temporal Trends in Antibiotic Use of New β-lactams for Gram-Negative Bacteria with Difficult-to-Treat Resistance in the Southeastern United States

Author

Vivian Tsai, Y, primary, Brandon Bookstaver, P, additional, Kohn, Joseph, additional, Ann Justo, Julie, additional, Childress, Darrell, additional, Stramel, Stefanie, additional, Slain, Douglas, additional, Tu, Patrick, additional, Wingler, Mary Joyce B, additional, Jones, Bruce M, additional, Anderson, Daniel, additional, Seddon, Megan M, additional, Gibson, Geneen, additional, Cretella, David A, additional, Eudy, Joshua, additional, Winders, Hana R, additional, Antosz, Kayla, additional, Bailey, Pamela, additional, and Al-Hasan, Majdi N, additional

Published
2022
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14. A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2020

Author

Green, Sarah B, primary, Stover, Kayla R, additional, Barber, Katie, additional, Bouchard, Jeannette L, additional, Brown, Matthew L, additional, Deri, Connor R, additional, Francis, Bailey J, additional, Gauthier, Timothy P, additional, Hayes, Jillian E, additional, Marx, Ashley H, additional, McGee, Edoabasi U, additional, Mediwala, Krutika, additional, Musgrove, Rachel J, additional, Slain, Douglas, additional, Stramel, Stefanie A, additional, Bland, Christopher M, additional, and Bookstaver, P Brandon, additional

Published
2021
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17. Questions about the 10 x '20 initiative

Author

Outterson, Kevin, Powers, John H., III, Gould, Ian M., Kesselheim, Aaron S., Burgess, David S., Slain, Douglas, Mohr, John, Wong-Beringer, Annie, Destache, Chris, and Suda, Katie

Subjects
United States. Food and Drug Administration -- Powers and duties, Anti-infective agents -- Usage, Anti-infective agents -- Health aspects, Anti-infective agents -- Licensing, certification and accreditation, Pharmaceutical policy -- Laws, regulations and rules, Communicable diseases -- Drug therapy, Government regulation, Health, Health care industry
Published
2010

18. Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2020.

Author

Green, Sarah B, Stover, Kayla R, Barber, Katie, Bouchard, Jeannette L, Brown, Matthew L, Deri, Connor R, Francis, Bailey J, Gauthier, Timothy P, Hayes, Jillian E, Marx, Ashley H, McGee, Edoabasi U, Mediwala, Krutika, Musgrove, Rachel J, Slain, Douglas, Stramel, Stefanie A, Bland, Christopher M, and Bookstaver, P Brandon

Subjects
ANTIMICROBIAL stewardship, DELPHI method, RESEARCH teams
Abstract

The number of articles related to antimicrobial stewardship published each year has increased significantly over the last decade. Keeping up with the literature, particularly the most innovative, well-designed, or applicable to one's own practice area, can be challenging. The Southeastern Research Group Endeavor (SERGE-45) network reviewed antimicrobial stewardship–related, peer-reviewed literature from 2020 that detailed actionable interventions. The top 13 publications were summarized following identification using a modified Delphi technique. This article highlights the selected interventions and may serve as a key resource for teaching and training, and to identify novel or optimized stewardship opportunities within one's institution. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Impact of an automatic hospital probiotic protocol on Clostridioides (Clostridium) difficile infection (CDI) rates and CDI antibiotic usage in a community hospital setting.

Author

Slain, Douglas, Georgulis, Amy, Dermitt, Ron, Morris, Laura, and Colodny, Stephen M

Subjects
*ANTIBIOTICS, *CROSS infection prevention, *THERAPEUTIC use of probiotics, *CLOSTRIDIUM diseases, *COMMUNITY health services, *COMPARATIVE studies, *CROSS infection, *INTRAVENOUS therapy, *ISOLATION (Hospital care), *LONGITUDINAL method, *METRONIDAZOLE, *MEDICAL protocols, *SCIENTIFIC observation, *ORAL drug administration, *PREVENTIVE health services, *QUALITY assurance, *VANCOMYCIN, *PROBIOTICS, *TREATMENT effectiveness, *PRE-tests & post-tests, *RETROSPECTIVE studies, *DESCRIPTIVE statistics
Abstract

The aim of the present study was to see how widespread preventative use of the probiotic Saccharomyces boulardii via automatic protocol in hospitalised patients receiving antibacterials affected rates of hospital-associated Clostridioides (Clostridium) difficile infection (HA-CDI). Rates of HA-CDI appeared to be similar between the pre-protocol and protocol periods. Use of CDI treatment antibiotics (oral metronidazole and oral vancomycin) was also similar. Laboratory-confirmed isolation of S. boulardii from sterile body sites was identified in five patients during the protocol versus only one case in the pre-protocol years. [ABSTRACT FROM AUTHOR]

Published
2020
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21. Impact of an automatic hospital probiotic protocol on Clostridioides(Clostridium) difficileinfection (CDI) rates and CDI antibiotic usage in a community hospital setting

Author

Slain, Douglas, Georgulis, Amy, Dermitt, Ron, Morris, Laura, and Colodny, Stephen M

Abstract

The aim of the present study was to see how widespread preventative use of the probiotic Saccharomyces boulardiivia automatic protocol in hospitalised patients receiving antibacterials affected rates of hospital-associated Clostridioides(Clostridium) difficileinfection (HA-CDI). Rates of HA-CDI appeared to be similar between the pre-protocol and protocol periods. Use of CDI treatment antibiotics (oral metronidazole and oral vancomycin) was also similar. Laboratory-confirmed isolation of S. boulardiifrom sterile body sites was identified in five patients during the protocol versus only one case in the pre-protocol years.

Published
2020
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27. Impact of a Multimodal Antimicrobial Stewardship Program onPseudomonas aeruginosaSusceptibility and Antimicrobial Use in the Intensive Care Unit Setting

Author

Slain, Douglas, primary, Sarwari, Arif R., additional, Petros, Karen O., additional, McKnight, Richard L., additional, Sager, Renee B., additional, Mullett, Charles J., additional, Wilson, Alison, additional, Thomas, John G., additional, Moffett, Kathryn, additional, Palmer, H. Carlton, additional, and Dedhia, Harakh V., additional

Published
2011
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28. Impact of a Multimodal Antimicrobial Stewardship Program on Pseudomonas aeruginosa Susceptibility and Antimicrobial Use in the Intensive Care Unit Setting.

Author

Slain, Douglas, Sarwari, Arif R., Petros, Karen O., McKnight, Richard L., Sager, Renee B., Mullett, Charles J., Wilson, Alison, Thomas, John G., Moffett, Kathryn, Palmer, H. Carlton, and Dedhia, Harakh V.

Subjects
*ANTIBIOTICS, *COMBINED modality therapy, *DISEASE susceptibility, *CIPROFLOXACIN, *INTENSIVE care units, *ANTI-infective agents
Abstract

Objective. To study the impact of our multimodal antibiotic stewardship program on Pseudomonas aeruginosa susceptibility and antibiotic use in the intensive care unit (ICU) setting. Methods. Our stewardship program employed the key tenants of published antimicrobial stewardship guidelines. These included prospective audits with intervention and feedback, formulary restriction with preauthorization, educational conferences, guidelines for use, antimicrobial cycling, and de-escalation of therapy. ICU antibiotic use was measured and expressed as defined daily doses (DDD) per 1,000 patient-days. Results. Certain temporal relationships between antibiotic use and ICU resistance patterns appeared to be affected by our antibiotic stewardship program. In particular, the ICU use of intravenous ciprofloxacin and ceftazidime declined from 148 and 62.5 DDD/1,000 patient-days to 40.0 and 24.5, respectively, during 2004 to 2007. An increase in the use of these agents and resistance to these agents was witnessed during 2008-2010. Despite variability in antibiotic usage from the stewardship efforts, we were overall unable to show statistical relationships with P. aeruginosa resistance rate. Conclusion. Antibiotic resistance in the ICU setting is complex. Multimodal stewardship efforts attempt to prevent resistance, but such programs clearly have their limits. [ABSTRACT FROM AUTHOR]

Published
2011
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30. Letter in response to the Infectious Diseases Society of America's 10 x '20 Initiative.

Author

Burgess DS, Slain D, Mohr J, Wong-Beringer A, Destache C, and Suda K

Subjects
Anti-Bacterial Agents therapeutic use, Drug Discovery methods, Drug Utilization standards, Health Policy, Humans, Anti-Bacterial Agents pharmacology, Bacterial Infections drug therapy, Bacterial Infections microbiology, Drug Discovery economics, Drug Discovery trends, Drug Resistance, Bacterial
Published
2010
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