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4. Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis

Author

Sichlau, Michael, Vlahos, Athanasios, Smith, Steven, Thalheimer, Quinn, Singh, Nisha, Harting, Rekha, Gocke, John, Guth, Scott, Shah, Neel, Brady, Paul, Schatz, Marvin, Horrow, Mindy, Markazi, Peyman, Forouzan, Leli, Matalon, Terence A.S., Hertzog, David, Goday, Swapna, Kennedy, Margaret, Kaplan, Robert, Campbell, Thomas, Hartman, Jamie, Nahum, Elmer, Venkat, Arvind, Krishnamurthy, Venkataramu, Rectenwald, John, Henke, Peter, Eliason, Jonathan, Willatt, Jonathon, Escobar, Guillermo, Samuels, Shaun, Katzen, Barry, Benenati, James, Powell, Alex, Pena, Constantino, Wallach, Howard, Gandhi, Ripal, Schneider, Joseph, Kim, Stanley, Hashemi, Farrah, Boyle, Joseph, Patel, Nilesh, Verta, Michael, Leung, Daniel, Garcia, Marc, Blatt, Phillip, Khatri, Jamil, Epstein, Dave, Ryan, Randall, Sweeny, Tom, Stillabower, Michael, Kimbiris, George, Raman, Tuhina, Sierzenski, Paul, Getto, Lelia, Dignazio, Michael, Horvath, Mark, Gornik, Heather, Bartholomew, John, Shishehbor, Mehdi, Peacock, Frank, Joseph, Douglas, Kim, Soo Hyum, Mahlay, Natalia Fendrikova, Clair, Daniel, Lyden, Sean, Kapoor, Baljendra, McLennon, Gordon, Pierce, Gregory, Newman, James, Spain, James, Gill, Amanjiit, Hamilton, Aaron, Rizzo, Anthony, Park, Woosup, Dietzek, Alan, Galin, Ira, Plummer, Dahlia, Hsu, Richard, Broderick, Patrick, Keller, Andrew, Sayeed, Sameer, Slater, Dennis, Lustberg, Herb, Akus, Jan, Sidman, Robert, Dhami, Mandeep, Kohanski, Phillip, Bulgaru, Anca, Dulala, Renuka, Burch, James, Kapur, Dinesh, Yang, Jie, Ranson, Mark, Wladis, Alan, Varnagy, David, Mekhail, Tarek, Winter, Robert, Perez-Izquierdo, Manuel, Motew, Stephen, Royd-Kranis, Robin, Workman, Raymond, Kribbs, Scott, Hogsette, Gerald, Moore, Phillip, Thomason, Bradley, Means, William, Bonsall, Richard, Stewart, John, Golwya, Daniel, Azene, Ezana, Bottner, Wayne, Bishop, William, Clayton, Dave, Gundersen, Lincoln, Riherd, Jody, Shakhnovich, Irina, Ziegelbein, Kurt, Chang, Thomas, Sharma, Karun, Allison, Sandra, Banovac, Fil, Cohen, Emil, Furlong, Brendan, Kessler, Craig, McCullough, Mike, Spies, Jim, Lin, Judith, Kaatz, Scott, Getzen, Todd, Miller, Joseph, Schwartz, Scott, Kabbani, Loay, McVinnie, David, Rundback, John, Manno, Joseph, Schwab, Richard, Cole, Randolph, Herman, Kevin, Singh, David, Barkama, Ravit, Patel, Amish, Comerota, Anthony, Pigott, John, Seiwert, Andrew, Whalen, Ralph, Russell, Todd, Assi, Zakaria, Kazanjian, Sahira, Yobbagy, Jonathan, Kaminski, Brian, Kaufman, Allan, Begeman, Garett, DiSalle, Robert, Thakur, Subash, Kim, Paul, Jacquet, Marc, Dykes, Thomas, Gerding, Joseph, Baker, Christopher, Debiasto, Mark, Mittleider, Derek, Higgins, George, III, Amberson, Steven, Pezzuti, Roger, Gallagher, Thomas, Schainfeld, Robert, Wicky, Stephan, Kalva, Sanjeeva, Walker, Gregory, Salazar, Gloria, Pomerantz, Benjamin, Patel, Virenda, Kabrhel, Christopher, Iqbal, Shams, Gangull, Suvranu, Oklu, Rahmi, Brannan, Scott, Misra, Sanjay, Bjarnason, Haraldur, Ashrani, Aneel, Caccavale, Michael, Fleming, Chad, Friese, Jeremy, Heit, John, Kalra, Manju, Macedo, Thanila, McBane, Robert, McKusick, Michael, Stockland, Andrew, Woodrum, David, Wysokinski, Waldemar, Verma, Adarsh, Davis, Andrew, Chung, Jerry, Nicker, David, Anderson, Brian, Stein, Robert, Weiss, Michael, Patel, Parag, Rilling, William, Tutton, Sean, Hieb, Robert, Hohenwalter, Eric, Colella, M. Riccardo, Gosset, James, White, Sarah, Lewis, Brian, Brown, Kellie, Rossi, Peter, Seabrook, Gary, Guimaraes, Marcelo, Selby, J. Bayne, McGary, William, Hannegan, Christopher, Robison, Jacob, Brothers, Thomas, Elliott, Bruce, Garg, Nitin, Anderson, M. Bret, Uflacker, Renan, Schonholz, Claudio, Raney, Laurence, Greenberg, Charles, Kaufman, John, Keller, Frederick, Kolbeck, Kenneth, Landry, Gregory, Mitchell, Erica, Barton, Robert, DeLoughery, Thomas, Kalbfleisch, Norman, Minjarez, Renee, Lakin, Paul, Liem, Timothy, Moneta, Gregory, Farsad, Khashayar, Fleischman, Ross, French, Loren, Marques, Vasco, Al−Hassani, Yasir, Sawar, Asad, Taylor, Frank, Patel, Rajul, Malhotra, Rahul, Hashemi, Farah, Padnick, Marvin, Gurley, Melissa, Cucher, Fred, Sterrenberg, Ronald, Deepthi, G. Reshmaal, Cumaranatunge, Gomes, Bhatla, Sumit, Jacobs, Darick, Dolen, Eric, Gamboa, Pablo, Dean, L. Mark, Davis, Thomas, Lippert, John, Khanna, Sanjeev, Schirf, Brian, Silber, Jeffrey, Wood, Donald, McGraw, J. Kevin, LaPerna, Lucy, Willette, Paul, Murphy, Timothy, Cerezo, Joselyn, Dhangana, Rajoo, Ahn, Sun Ho, Dubel, Gregory, Haas, Richard, Jay, Bryan, Prince, Ethan, Soares, Gregory, Klinger, James, Lambiase, Robert, Jay, Gregory, Tubbs, Robert, Beland, Michael, Hampson, Chris, O'Hara, Ryan, Thompson, Chad, Frodsham, Aaron, Gardiner, Fenwick, Jaffan, Abdel, Keating, Lawrence, Zafar, Abdul, Alicic, Radica, Raabe, Rodney, Brower, Jayson, McClellan, David, Pellow, Thomas, Zylak, Christopher, Davis, Joseph, Reilly, M. Kathleen, Symington, Kenneth, Seibold, Camerson, Nachreiner, Ryan, Murray, Daniel, Murray, Stephen, Saha, Sandeep, Luna, Gregory, Hodgson, Kim, McLafferty, Robert, Hood, Douglas, Moore, Colleen, Griffen, David, Hurst, Darren, Lubbers, David, Kim, Daniel, Warren, Brent, Engel, Jeremy, Suresh, D.P., VanderWoude, Eric, Razdan, Rahul, Hutchins, Mark, Rounsborg, Terry, Midathada, Madhu, Moravec, Daniel, Tilford, Joni, Beckman, Joni, Razavi, Mahmood, Openshaw, Kurt, Flanigan, D. Preston, Loh, Christopher, Dorne, Howard, Chan, Michael, Thomas, Jamie, Psaila, Justin, Ringold, Michael, Fisher, Jay, Lipcomb, Any, Oskin, Timothy, Wible, Brandt, Coleman, Brendan, Elliott, David, Gaddis, Gary, Cochran, C. Doug, Natarajan, Kannan, Bick, Stewart, Cooke, Jeffrey, Hedderman, Ann, Greist, Anne, Miller, Lorrie, Martinez, Brandon, Flanders, Vincent, Underhill, Mark, Hofmann, Lawrence, Sze, Daniel, Kuo, William, Louie, John, Hwang, Gloria, Hovsepian, David, Kothary, Nishita, Berube, Caroline, Schreiber, Donald, Jeffrey, Brooke, Schor, Jonathan, Deitch, Jonathan, Singh, Kuldeep, Hahn, Barry, Ardolic, Brahim, Gupta, Shilip, Bashir, Riyaz, Rao, Angara Koneti, Garg, Manish, Patil, Pravin, Zack, Chad, Cohen, Gary, Schmieder, Frank, Lakhter, Valdimir, Sacks, David, Guay, Robert, Scott, Mark, Cunningham, Karekin, Sigal, Adam, Cescon, Terrence, Leasure, Nick, Dhurairaj, Thiruvenkatasamy, Muck, Patrick, Knochel, Kurt, Lohr, Joann, Barreau, Jose, Recht, Matthew, Bhaskaran, Jayapandia, Brahmamdam, Ranga, Draper, David, Mehta, Apurva, Maher, James, Sharafuddin, Melhem, Lentz, Steven, Nugent, Andrew, Sharp, William, Kresowik, Timothy, Nicholson, Rachel, Sun, Shiliang, Youness, Fadi, Pascarella, Luigi, Ray, Charles, Knuttinen, Martha-Gracia, Bui, James, Gaba, Ron, Dobiesz, Valerie, Shamim, Ejaz, Nimmagadda, Sangeetha, Peace, David, Zain, Aarti, Palumto, Alison, Haskal, Ziv, Hirshon, Jon Mark, Richard, Howard, Verceles, Avelino, Wong-You-Chong, Jade, Othee, Bertrand, Patel, Rahul, Iliescu, Bogdan, Williams, David, Gemmete, Joseph, Cwikiel, Wojciech, Cho, Kyung, Schields, James, Vellody, Ranjith, Novelli, Paula, Dasika, Narasimham, Wakefield, Thomas, Desmond, Jeffrey, Froehlich, James, Khaja, Minhajuddin, Hunter, David, Golzarian, Jafar, Cressman, Erik, Dotta, Yvonne, Schmiechen, Nate, Marek, John, Garcia, David, Tawil, Isaac, Langsfeld, Mark, Moll, Stephan, Mauro, Matthew, Stavas, Joseph, Burke, Charles, Dixon, Robert, Yu, Hyeon, Keagy, Blair, Kim, Kyuny, Kasthuri, Raj, Key, Nigel, Chaer, Rabih, Makaroun, Michael, Rhee, Robert, Cho, Jae−Sung, Baril, Donald, Marone, Luke, Hseih, Margaret, Feterik, Kristian, Smith, Roy, Jeyabalan, Geetha, Rogers, Jennifer, Vinik, Russel, Kinikini, Dan, Kraiss, Larry, Mueller, Michelle, Pendleton, Robert, Rondina, Matthew, Sarfati, Mark, Wanner, Nathan, Johnson, Stacy, Hopkins, Christy, Ihnat, Daniel, Angle, John, Matsumoto, Alan, Harthun, Nancy, Turba, Ulku, Saad, Wael, Uthlaut, Brian, Nannapaneni, Srikant, Ling, David, Sabri, Saher, Kern, John, Macik, B. Gail, Hoke, George, Park, Auh Wahn, Stone, James, Sneed, Benjamin, Syverud, Scott, Davidson, Kelly, Sharma, Aditya, Wilkins, Luke, Black, Carl, Asay, Mark, Hatch, Daniel, Smilanich, Robert, Patten, Craig, Brown, S. Douglas, Nielsen, Ryan, Alward, William, Collins, John, Nokes, Matthew, Geary, Randolph, Edwards, Matthew, Godshall, Christopher, Levy, Pavel, Winokur, Ronald, Sista, Akhilesh, Madoff, David, Lee, Kyungmouk, Pua, Bradley, DeSancho, Maria, Milizia, Raffaele, Gao, Jing, McLean, Gordon, Khalid, Sanualah, Vedantham, Suresh, Lewis, Larry, Saad, Nael, Thoelke, Mark, Pallow, Robert, Klein, Seth, Sicard, Gregorio, Cohen, David J., Comerota, Anthony J., Gornik, Heather L., Jaff, Michael R., Julian, Jim, Kahn, Susan R., Kearon, Clive, Kee, Stephen, Kindzelski, Andrei L., Lewis, Lawrence, Magnuson, Elizabeth, Razavi, Mahmood K., Murphy, Timothy P., Julian, Jim A., Gu, Chu-Shu, Magnuson, Elizabeth A., Goldhaber, Samuel Z., Schneider, Joseph R., Sista, Akhilesh K., McLafferty, Robert B., Kaufman, John A., Wible, Brandt C., and Blinder, Morey

Published
2020
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8. Reduced CT iodine perfusion score is associated with adverse clinical outcomes in acute pulmonary embolism

Author

Yuriditsky, Eugene, primary, Mitchell, Oscar J L, additional, Moore, William H, additional, Sista, Akhilesh K, additional, Brosnahan, Shari B, additional, Cruz, Rogelio, additional, Amoroso, Nancy E, additional, Goldenberg, Ronald M, additional, Smith, Deane E, additional, Jamin, Catherine, additional, Maldonado, Thomas S, additional, and Horowitz, James M, additional

Published
2022
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9. Pharmacomechanical Catheter-Directed Thrombolysis With the Bashir Endovascular Catheter for Acute Pulmonary Embolism

Author

Bashir, Riyaz, primary, Foster, Malcolm, additional, Iskander, Ayman, additional, Darki, Amir, additional, Jaber, Wissam, additional, Rali, Parth M., additional, Lakhter, Vladimir, additional, Gandhi, Ripal, additional, Klein, Andrew, additional, Bhatheja, Rohit, additional, Ross, Charles, additional, Natarajan, Kannan, additional, Nanjundappa, Aravinda, additional, Angle, John F., additional, Ouriel, Kenneth, additional, Amoroso, Nancy E., additional, Firth, Brian G., additional, Comerota, Anthony J., additional, Piazza, Gregory, additional, Rosenfield, Kenneth, additional, and Sista, Akhilesh K., additional

Published
2022
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15. sj-pdf-1-vmj-10.1177_1358863X221143818 – Supplemental material for Reduced CT iodine perfusion score is associated with adverse clinical outcomes in acute pulmonary embolism

Author

Yuriditsky, Eugene, Mitchell, Oscar J L, Moore, William H, Sista, Akhilesh K, Brosnahan, Shari B, Cruz, Rogelio, Amoroso, Nancy E, Goldenberg, Ronald M, Smith, Deane E, Jamin, Catherine, Maldonado, Thomas S, and Horowitz, James M

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221143818 for Reduced CT iodine perfusion score is associated with adverse clinical outcomes in acute pulmonary embolism by Eugene Yuriditsky, Oscar J L Mitchell, William H Moore, Akhilesh K Sista, Shari B Brosnahan, Rogelio Cruz, Nancy E Amoroso, Ronald M Goldenberg, Deane E Smith, Catherine Jamin, Thomas S Maldonado and James M Horowitz in Vascular Medicine

Published
2022
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16. sj-pdf-1-vmj-10.1177_1358863X221124681 – Supplemental material for Mechanical aspiration thrombectomy for the treatment of pulmonary embolism: A systematic review and meta-analysis

Author

Chandra, Vishnu M, Khaja, Minhaj S, Kryger, Marc C, Sista, Akhilesh K, Wilkins, Luke R, Angle, John F, and Sharma, Aditya M

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221124681 for Mechanical aspiration thrombectomy for the treatment of pulmonary embolism: A systematic review and meta-analysis by Vishnu M Chandra, Minhaj S Khaja, Marc C Kryger, Akhilesh K Sista, Luke R Wilkins, John F Angle and Aditya M Sharma in Vascular Medicine

Published
2022
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19. Reply

Author

Sista, Akhilesh K., primary, Horowitz, James M., additional, Tapson, Victor F., additional, and Benenati, James F., additional

Published
2021
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20. sj-pdf-1-vmj-10.1177_1358863X211048544 – Supplemental material for National trends in utilization of thrombolytic therapy for acute pulmonary embolism

Author

Beyer, Sebastian E, Shanafelt, Colby, Pinto, Duane S, Weinstein, Jeffrey L, Giri, Jay, Sista, Akhilesh K, Yeh, Robert W, Secemsky, Eric A, and Carroll, Brett J

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X211048544 for National trends in utilization of thrombolytic therapy for acute pulmonary embolism by Sebastian E Beyer, Colby Shanafelt, Duane S Pinto, Jeffrey L Weinstein, Jay Giri, Akhilesh K Sista, Robert W Yeh, Eric A Secemsky and Brett J Carroll in Vascular Medicine

Published
2021
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21. sj-pdf-2-vmj-10.1177_1358863X16670250 – Supplemental material for Persistent right ventricular dysfunction, functional capacity limitation, exercise intolerance, and quality of life impairment following pulmonary embolism: Systematic review with meta-analysis

Author

Sista, Akhilesh K, Miller, Larry E, Kahn, Susan R, and Kline, Jeffrey A

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental material, sj-pdf-2-vmj-10.1177_1358863X16670250 for Persistent right ventricular dysfunction, functional capacity limitation, exercise intolerance, and quality of life impairment following pulmonary embolism: Systematic review with meta-analysis by Akhilesh K Sista, Larry E Miller, Susan R Kahn and Jeffrey A Kline in Vascular Medicine

Published
2021
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22. sj-pdf-1-vmj-10.1177_1358863X16670250 – Supplemental material for Persistent right ventricular dysfunction, functional capacity limitation, exercise intolerance, and quality of life impairment following pulmonary embolism: Systematic review with meta-analysis

Author

Sista, Akhilesh K, Miller, Larry E, Kahn, Susan R, and Kline, Jeffrey A

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X16670250 for Persistent right ventricular dysfunction, functional capacity limitation, exercise intolerance, and quality of life impairment following pulmonary embolism: Systematic review with meta-analysis by Akhilesh K Sista, Larry E Miller, Susan R Kahn and Jeffrey A Kline in Vascular Medicine

Published
2021
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23. First-in-Human Study to Assess the Safety and Feasibility of the Bashir Endovascular Catheter for the Treatment of Acute Intermediate-Risk Pulmonary Embolism

Author

Sista, Akhilesh K., primary, Bhatheja, Rohit, additional, Rali, Parth, additional, Natarajan, Kannan, additional, Green, Philip, additional, Piazza, Gregory, additional, Comerota, Anthony J., additional, Parikh, Sahil A., additional, Lakhter, Vladimir, additional, Bashir, Riyaz, additional, and Rosenfield, Kenneth, additional

Published
2021
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25. Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis

Author

Kahn, Susan R., primary, Julian, Jim A., additional, Kearon, Clive, additional, Gu, Chu-Shu, additional, Cohen, David J., additional, Magnuson, Elizabeth A., additional, Comerota, Anthony J., additional, Goldhaber, Samuel Z., additional, Jaff, Michael R., additional, Razavi, Mahmood K., additional, Kindzelski, Andrei L., additional, Schneider, Joseph R., additional, Kim, Paul, additional, Chaer, Rabih, additional, Sista, Akhilesh K., additional, McLafferty, Robert B., additional, Kaufman, John A., additional, Wible, Brandt C., additional, Blinder, Morey, additional, Vedantham, Suresh, additional, Sichlau, Michael, additional, Vlahos, Athanasios, additional, Smith, Steven, additional, Thalheimer, Quinn, additional, Singh, Nisha, additional, Harting, Rekha, additional, Gocke, John, additional, Guth, Scott, additional, Shah, Neel, additional, Brady, Paul, additional, Schatz, Marvin, additional, Horrow, Mindy, additional, Markazi, Peyman, additional, Forouzan, Leli, additional, Matalon, Terence A.S., additional, Hertzog, David, additional, Goday, Swapna, additional, Kennedy, Margaret, additional, Kaplan, Robert, additional, Campbell, Thomas, additional, Hartman, Jamie, additional, Nahum, Elmer, additional, Venkat, Arvind, additional, Krishnamurthy, Venkataramu, additional, Rectenwald, John, additional, Henke, Peter, additional, Eliason, Jonathan, additional, Willatt, Jonathon, additional, Escobar, Guillermo, additional, Samuels, Shaun, additional, Katzen, Barry, additional, Benenati, James, additional, Powell, Alex, additional, Pena, Constantino, additional, Wallach, Howard, additional, Gandhi, Ripal, additional, Schneider, Joseph, additional, Kim, Stanley, additional, Hashemi, Farrah, additional, Boyle, Joseph, additional, Patel, Nilesh, additional, Verta, Michael, additional, Leung, Daniel, additional, Garcia, Marc, additional, Blatt, Phillip, additional, Khatri, Jamil, additional, Epstein, Dave, additional, Ryan, Randall, additional, Sweeny, Tom, additional, Stillabower, Michael, additional, Kimbiris, George, additional, Raman, Tuhina, additional, Sierzenski, Paul, additional, Getto, Lelia, additional, Dignazio, Michael, additional, Horvath, Mark, additional, Gornik, Heather, additional, Bartholomew, John, additional, Shishehbor, Mehdi, additional, Peacock, Frank, additional, Joseph, Douglas, additional, Kim, Soo Hyum, additional, Mahlay, Natalia Fendrikova, additional, Clair, Daniel, additional, Lyden, Sean, additional, Kapoor, Baljendra, additional, McLennon, Gordon, additional, Pierce, Gregory, additional, Newman, James, additional, Spain, James, additional, Gill, Amanjiit, additional, Hamilton, Aaron, additional, Rizzo, Anthony, additional, Park, Woosup, additional, Dietzek, Alan, additional, Galin, Ira, additional, Plummer, Dahlia, additional, Hsu, Richard, additional, Broderick, Patrick, additional, Keller, Andrew, additional, Sayeed, Sameer, additional, Slater, Dennis, additional, Lustberg, Herb, additional, Akus, Jan, additional, Sidman, Robert, additional, Dhami, Mandeep, additional, Kohanski, Phillip, additional, Bulgaru, Anca, additional, Dulala, Renuka, additional, Burch, James, additional, Kapur, Dinesh, additional, Yang, Jie, additional, Ranson, Mark, additional, Wladis, Alan, additional, Varnagy, David, additional, Mekhail, Tarek, additional, Winter, Robert, additional, Perez-Izquierdo, Manuel, additional, Motew, Stephen, additional, Royd-Kranis, Robin, additional, Workman, Raymond, additional, Kribbs, Scott, additional, Hogsette, Gerald, additional, Moore, Phillip, additional, Thomason, Bradley, additional, Means, William, additional, Bonsall, Richard, additional, Stewart, John, additional, Golwya, Daniel, additional, Azene, Ezana, additional, Bottner, Wayne, additional, Bishop, William, additional, Clayton, Dave, additional, Gundersen, Lincoln, additional, Riherd, Jody, additional, Shakhnovich, Irina, additional, Ziegelbein, Kurt, additional, Chang, Thomas, additional, Sharma, Karun, additional, Allison, Sandra, additional, Banovac, Fil, additional, Cohen, Emil, additional, Furlong, Brendan, additional, Kessler, Craig, additional, McCullough, Mike, additional, Spies, Jim, additional, Lin, Judith, additional, Kaatz, Scott, additional, Getzen, Todd, additional, Miller, Joseph, additional, Schwartz, Scott, additional, Kabbani, Loay, additional, McVinnie, David, additional, Rundback, John, additional, Manno, Joseph, additional, Schwab, Richard, additional, Cole, Randolph, additional, Herman, Kevin, additional, Singh, David, additional, Barkama, Ravit, additional, Patel, Amish, additional, Comerota, Anthony, additional, Pigott, John, additional, Seiwert, Andrew, additional, Whalen, Ralph, additional, Russell, Todd, additional, Assi, Zakaria, additional, Kazanjian, Sahira, additional, Yobbagy, Jonathan, additional, Kaminski, Brian, additional, Kaufman, Allan, additional, Begeman, Garett, additional, DiSalle, Robert, additional, Thakur, Subash, additional, Jacquet, Marc, additional, Dykes, Thomas, additional, Gerding, Joseph, additional, Baker, Christopher, additional, Debiasto, Mark, additional, Mittleider, Derek, additional, Higgins, George, additional, Amberson, Steven, additional, Pezzuti, Roger, additional, Gallagher, Thomas, additional, Schainfeld, Robert, additional, Wicky, Stephan, additional, Kalva, Sanjeeva, additional, Walker, Gregory, additional, Salazar, Gloria, additional, Pomerantz, Benjamin, additional, Patel, Virenda, additional, Kabrhel, Christopher, additional, Iqbal, Shams, additional, Gangull, Suvranu, additional, Oklu, Rahmi, additional, Brannan, Scott, additional, Misra, Sanjay, additional, Bjarnason, Haraldur, additional, Ashrani, Aneel, additional, Caccavale, Michael, additional, Fleming, Chad, additional, Friese, Jeremy, additional, Heit, John, additional, Kalra, Manju, additional, Macedo, Thanila, additional, McBane, Robert, additional, McKusick, Michael, additional, Stockland, Andrew, additional, Woodrum, David, additional, Wysokinski, Waldemar, additional, Verma, Adarsh, additional, Davis, Andrew, additional, Chung, Jerry, additional, Nicker, David, additional, Anderson, Brian, additional, Stein, Robert, additional, Weiss, Michael, additional, Patel, Parag, additional, Rilling, William, additional, Tutton, Sean, additional, Hieb, Robert, additional, Hohenwalter, Eric, additional, Colella, M. Riccardo, additional, Gosset, James, additional, White, Sarah, additional, Lewis, Brian, additional, Brown, Kellie, additional, Rossi, Peter, additional, Seabrook, Gary, additional, Guimaraes, Marcelo, additional, Selby, J. Bayne, additional, McGary, William, additional, Hannegan, Christopher, additional, Robison, Jacob, additional, Brothers, Thomas, additional, Elliott, Bruce, additional, Garg, Nitin, additional, Anderson, M. Bret, additional, Uflacker, Renan, additional, Schonholz, Claudio, additional, Raney, Laurence, additional, Greenberg, Charles, additional, Kaufman, John, additional, Keller, Frederick, additional, Kolbeck, Kenneth, additional, Landry, Gregory, additional, Mitchell, Erica, additional, Barton, Robert, additional, DeLoughery, Thomas, additional, Kalbfleisch, Norman, additional, Minjarez, Renee, additional, Lakin, Paul, additional, Liem, Timothy, additional, Moneta, Gregory, additional, Farsad, Khashayar, additional, Fleischman, Ross, additional, French, Loren, additional, Marques, Vasco, additional, Al−Hassani, Yasir, additional, Sawar, Asad, additional, Taylor, Frank, additional, Patel, Rajul, additional, Malhotra, Rahul, additional, Hashemi, Farah, additional, Padnick, Marvin, additional, Gurley, Melissa, additional, Cucher, Fred, additional, Sterrenberg, Ronald, additional, Deepthi, G. Reshmaal, additional, Cumaranatunge, Gomes, additional, Bhatla, Sumit, additional, Jacobs, Darick, additional, Dolen, Eric, additional, Gamboa, Pablo, additional, Dean, L. Mark, additional, Davis, Thomas, additional, Lippert, John, additional, Khanna, Sanjeev, additional, Schirf, Brian, additional, Silber, Jeffrey, additional, Wood, Donald, additional, McGraw, J. Kevin, additional, LaPerna, Lucy, additional, Willette, Paul, additional, Murphy, Timothy, additional, Cerezo, Joselyn, additional, Dhangana, Rajoo, additional, Ahn, Sun Ho, additional, Dubel, Gregory, additional, Haas, Richard, additional, Jay, Bryan, additional, Prince, Ethan, additional, Soares, Gregory, additional, Klinger, James, additional, Lambiase, Robert, additional, Jay, Gregory, additional, Tubbs, Robert, additional, Beland, Michael, additional, Hampson, Chris, additional, O'Hara, Ryan, additional, Thompson, Chad, additional, Frodsham, Aaron, additional, Gardiner, Fenwick, additional, Jaffan, Abdel, additional, Keating, Lawrence, additional, Zafar, Abdul, additional, Alicic, Radica, additional, Raabe, Rodney, additional, Brower, Jayson, additional, McClellan, David, additional, Pellow, Thomas, additional, Zylak, Christopher, additional, Davis, Joseph, additional, Reilly, M. Kathleen, additional, Symington, Kenneth, additional, Seibold, Camerson, additional, Nachreiner, Ryan, additional, Murray, Daniel, additional, Murray, Stephen, additional, Saha, Sandeep, additional, Luna, Gregory, additional, Hodgson, Kim, additional, McLafferty, Robert, additional, Hood, Douglas, additional, Moore, Colleen, additional, Griffen, David, additional, Hurst, Darren, additional, Lubbers, David, additional, Kim, Daniel, additional, Warren, Brent, additional, Engel, Jeremy, additional, Suresh, D.P., additional, VanderWoude, Eric, additional, Razdan, Rahul, additional, Hutchins, Mark, additional, Rounsborg, Terry, additional, Midathada, Madhu, additional, Moravec, Daniel, additional, Tilford, Joni, additional, Beckman, Joni, additional, Razavi, Mahmood, additional, Openshaw, Kurt, additional, Flanigan, D. Preston, additional, Loh, Christopher, additional, Dorne, Howard, additional, Chan, Michael, additional, Thomas, Jamie, additional, Psaila, Justin, additional, Ringold, Michael, additional, Fisher, Jay, additional, Lipcomb, Any, additional, Oskin, Timothy, additional, Wible, Brandt, additional, Coleman, Brendan, additional, Elliott, David, additional, Gaddis, Gary, additional, Cochran, C. Doug, additional, Natarajan, Kannan, additional, Bick, Stewart, additional, Cooke, Jeffrey, additional, Hedderman, Ann, additional, Greist, Anne, additional, Miller, Lorrie, additional, Martinez, Brandon, additional, Flanders, Vincent, additional, Underhill, Mark, additional, Hofmann, Lawrence, additional, Sze, Daniel, additional, Kuo, William, additional, Louie, John, additional, Hwang, Gloria, additional, Hovsepian, David, additional, Kothary, Nishita, additional, Berube, Caroline, additional, Schreiber, Donald, additional, Jeffrey, Brooke, additional, Schor, Jonathan, additional, Deitch, Jonathan, additional, Singh, Kuldeep, additional, Hahn, Barry, additional, Ardolic, Brahim, additional, Gupta, Shilip, additional, Bashir, Riyaz, additional, Rao, Angara Koneti, additional, Garg, Manish, additional, Patil, Pravin, additional, Zack, Chad, additional, Cohen, Gary, additional, Schmieder, Frank, additional, Lakhter, Valdimir, additional, Sacks, David, additional, Guay, Robert, additional, Scott, Mark, additional, Cunningham, Karekin, additional, Sigal, Adam, additional, Cescon, Terrence, additional, Leasure, Nick, additional, Dhurairaj, Thiruvenkatasamy, additional, Muck, Patrick, additional, Knochel, Kurt, additional, Lohr, Joann, additional, Barreau, Jose, additional, Recht, Matthew, additional, Bhaskaran, Jayapandia, additional, Brahmamdam, Ranga, additional, Draper, David, additional, Mehta, Apurva, additional, Maher, James, additional, Sharafuddin, Melhem, additional, Lentz, Steven, additional, Nugent, Andrew, additional, Sharp, William, additional, Kresowik, Timothy, additional, Nicholson, Rachel, additional, Sun, Shiliang, additional, Youness, Fadi, additional, Pascarella, Luigi, additional, Ray, Charles, additional, Knuttinen, Martha-Gracia, additional, Bui, James, additional, Gaba, Ron, additional, Dobiesz, Valerie, additional, Shamim, Ejaz, additional, Nimmagadda, Sangeetha, additional, Peace, David, additional, Zain, Aarti, additional, Palumto, Alison, additional, Haskal, Ziv, additional, Hirshon, Jon Mark, additional, Richard, Howard, additional, Verceles, Avelino, additional, Wong-You-Chong, Jade, additional, Othee, Bertrand, additional, Patel, Rahul, additional, Iliescu, Bogdan, additional, Williams, David, additional, Gemmete, Joseph, additional, Cwikiel, Wojciech, additional, Cho, Kyung, additional, Schields, James, additional, Vellody, Ranjith, additional, Novelli, Paula, additional, Dasika, Narasimham, additional, Wakefield, Thomas, additional, Desmond, Jeffrey, additional, Froehlich, James, additional, Khaja, Minhajuddin, additional, Hunter, David, additional, Golzarian, Jafar, additional, Cressman, Erik, additional, Dotta, Yvonne, additional, Schmiechen, Nate, additional, Marek, John, additional, Garcia, David, additional, Tawil, Isaac, additional, Langsfeld, Mark, additional, Moll, Stephan, additional, Mauro, Matthew, additional, Stavas, Joseph, additional, Burke, Charles, additional, Dixon, Robert, additional, Yu, Hyeon, additional, Keagy, Blair, additional, Kim, Kyuny, additional, Kasthuri, Raj, additional, Key, Nigel, additional, Makaroun, Michael, additional, Rhee, Robert, additional, Cho, Jae−Sung, additional, Baril, Donald, additional, Marone, Luke, additional, Hseih, Margaret, additional, Feterik, Kristian, additional, Smith, Roy, additional, Jeyabalan, Geetha, additional, Rogers, Jennifer, additional, Vinik, Russel, additional, Kinikini, Dan, additional, Kraiss, Larry, additional, Mueller, Michelle, additional, Pendleton, Robert, additional, Rondina, Matthew, additional, Sarfati, Mark, additional, Wanner, Nathan, additional, Johnson, Stacy, additional, Hopkins, Christy, additional, Ihnat, Daniel, additional, Angle, John, additional, Matsumoto, Alan, additional, Harthun, Nancy, additional, Turba, Ulku, additional, Saad, Wael, additional, Uthlaut, Brian, additional, Nannapaneni, Srikant, additional, Ling, David, additional, Sabri, Saher, additional, Kern, John, additional, Macik, B. Gail, additional, Hoke, George, additional, Park, Auh Wahn, additional, Stone, James, additional, Sneed, Benjamin, additional, Syverud, Scott, additional, Davidson, Kelly, additional, Sharma, Aditya, additional, Wilkins, Luke, additional, Black, Carl, additional, Asay, Mark, additional, Hatch, Daniel, additional, Smilanich, Robert, additional, Patten, Craig, additional, Brown, S. Douglas, additional, Nielsen, Ryan, additional, Alward, William, additional, Collins, John, additional, Nokes, Matthew, additional, Geary, Randolph, additional, Edwards, Matthew, additional, Godshall, Christopher, additional, Levy, Pavel, additional, Winokur, Ronald, additional, Sista, Akhilesh, additional, Madoff, David, additional, Lee, Kyungmouk, additional, Pua, Bradley, additional, DeSancho, Maria, additional, Milizia, Raffaele, additional, Gao, Jing, additional, McLean, Gordon, additional, Khalid, Sanualah, additional, Lewis, Larry, additional, Saad, Nael, additional, Thoelke, Mark, additional, Pallow, Robert, additional, Klein, Seth, additional, Sicard, Gregorio, additional, Gornik, Heather L., additional, Julian, Jim, additional, Kahn, Susan R., additional, Kee, Stephen, additional, Lewis, Lawrence, additional, Magnuson, Elizabeth, additional, and Murphy, Timothy P., additional

Published
2020
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26. Reduced CT iodine perfusion score is associated with adverse clinical outcomes in acute pulmonary embolism.

Author

Yuriditsky, Eugene, Mitchell, Oscar J L, Moore, William H, Sista, Akhilesh K, Brosnahan, Shari B, Cruz, Rogelio, Amoroso, Nancy E, Goldenberg, Ronald M, Smith, Deane E, Jamin, Catherine, Maldonado, Thomas S, and Horowitz, James M

Subjects
PULMONARY embolism, PERFUSION, IODINE, TREATMENT effectiveness, ARTIFICIAL intelligence
Abstract

Patients meeting the combined outcome of AIDE and IHCA were predominantly categorized as submassive PE (19 of 21 patients) with one uncomplicated and one massive PE patient. Keywords: pulmonary embolism (PE); risk stratification; venous thromboembolism (VTE); biomarkers; vascular imaging EN pulmonary embolism (PE) risk stratification venous thromboembolism (VTE) biomarkers vascular imaging 59 61 3 02/14/23 20230201 NES 230201 Risk stratification in acute pulmonary embolism (PE) is critical in identifying patients most likely to suffer clinical decompensation and therefore more likely to benefit from advanced therapies. [Extracted from the article]

Published
2023
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27. Low left ventricular outflow tract velocity time integral is associated with poor outcomes in acute pulmonary embolism

Author

Yuriditsky, Eugene, primary, Mitchell, Oscar JL, additional, Sibley, Rachel A, additional, Xia, Yuhe, additional, Sista, Akhilesh K, additional, Zhong, Judy, additional, Moore, William H, additional, Amoroso, Nancy E, additional, Goldenberg, Ronald M, additional, Smith, Deane E, additional, Jamin, Catherine, additional, Brosnahan, Shari B, additional, Maldonado, Thomas S, additional, and Horowitz, James M, additional

Published
2019
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28. How the Results of a Randomized Trial of Catheter-Directed Thrombolysis Versus Anticoagulation alone for Submassive Pulmonary Embolism Would Affect Patient and Physician Decision Making: Report of an Online Survey

Author

Taslakian, Bedros, primary, Li, Clayton, additional, Goldhaber, Samuel Z, additional, Mikkelsen, Kathryn Z, additional, Horowitz, James M, additional, Kabrhel, Christopher, additional, Barnes, Geoffrey D, additional, and Sista, Akhilesh K, additional

Published
2019
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29. Optical imaging of the peri-tumoral inflammatory response in breast cancer

Author

Reinhart Verena, Ansari Celina, Kishore Sirish A, Boddington Sophie E, DeNardo David G, Johansson Magnus, Tavri Sidhartha, Knebel Robert J, Sista Akhilesh K, Coakley Fergus V, Coussens Lisa M, and Daldrup-Link Heike E

Subjects
Medicine
Abstract

Abstract Purpose Peri-tumoral inflammation is a common tumor response that plays a central role in tumor invasion and metastasis, and inflammatory cell recruitment is essential to this process. The purpose of this study was to determine whether injected fluorescently-labeled monocytes accumulate within murine breast tumors and are visible with optical imaging. Materials and methods Murine monocytes were labeled with the fluorescent dye DiD and subsequently injected intravenously into 6 transgenic MMTV-PymT tumor-bearing mice and 6 FVB/n control mice without tumors. Optical imaging (OI) was performed before and after cell injection. Ratios of post-injection to pre-injection fluorescent signal intensity of the tumors (MMTV-PymT mice) and mammary tissue (FVB/n controls) were calculated and statistically compared. Results MMTV-PymT breast tumors had an average post/pre signal intensity ratio of 1.8+/- 0.2 (range 1.1-2.7). Control mammary tissue had an average post/pre signal intensity ratio of 1.1 +/- 0.1 (range, 0.4 to 1.4). The p-value for the difference between the ratios was less than 0.05. Confocal fluorescence microscopy confirmed the presence of DiD-labeled cells within the breast tumors. Conclusion Murine monocytes accumulate at the site of breast cancer development in this transgenic model, providing evidence that peri-tumoral inflammatory cell recruitment can be evaluated non-invasively using optical imaging.

Published
2009
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32. Low left ventricular outflow tract velocity time integral is associated with poor outcomes in acute pulmonary embolism.

Author

Yuriditsky, Eugene, Mitchell, Oscar JL, Sibley, Rachel A, Xia, Yuhe, Sista, Akhilesh K, Zhong, Judy, Moore, William H, Amoroso, Nancy E, Goldenberg, Ronald M, Smith, Deane E, Jamin, Catherine, Brosnahan, Shari B, Maldonado, Thomas S, and Horowitz, James M

Subjects
PULMONARY embolism, CARDIAC arrest, VELOCITY, ECHOCARDIOGRAPHY, ODDS ratio
Abstract

The left ventricular outflow tract (LVOT) velocity time integral (VTI) is an easily measured echocardiographic stroke volume index analog. Low values predict adverse outcomes in left ventricular failure. We postulate the left ventricular VTI may be a signal of right ventricular dysfunction in acute pulmonary embolism, and therefore a predictor of poor outcomes. We retrospectively reviewed echocardiograms on all Pulmonary Embolism Response Team activations at our institution at the time of pulmonary embolism diagnosis. Low LVOT VTI was defined as ⩽ 15 cm. We examined two composite outcomes: (1) in-hospital death or cardiac arrest; and (2) shock or need for primary reperfusion therapies. Sixty-one of 188 patients (32%) had a LVOT VTI of ⩽ 15 cm. Low VTI was associated with in-hospital death or cardiac arrest (odds ratio (OR) 6, 95% CI 2, 17.9; p = 0.0014) and shock or need for reperfusion (OR 23.3, 95% CI 6.6, 82.1; p < 0.0001). In a multivariable model, LVOT VTI ⩽ 15 remained significant for death or cardiac arrest (OR 3.48, 95% CI 1.02, 11.9; p = 0.047) and for shock or need for reperfusion (OR 8.12, 95% CI 1.62, 40.66; p = 0.011). Among intermediate–high-risk patients, low VTI was the only variable associated with the composite outcome of death, cardiac arrest, shock, or need for reperfusion (OR 14, 95% CI 1.7, 118.4; p = 0.015). LVOT VTI is associated with adverse short-term outcomes in acute pulmonary embolism. The VTI may help risk stratify patients with intermediate–high-risk pulmonary embolism. [ABSTRACT FROM AUTHOR]

Published
2020
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34. Acute pulmonary embolism: endovascular therapy

Author

Reis, Stephen P., primary, Zhao, Ken, additional, Ahmad, Noor, additional, Widemon, Reginald S., additional, Root, Christopher W., additional, Toomay, Seth M., additional, Horowitz, James M., additional, and Sista, Akhilesh K., additional

Published
2018
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38. Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel

Author

Vedantham, Suresh, primary, Kahn, Susan R, additional, Goldhaber, Samuel Z, additional, Comerota, Anthony J, additional, Parpia, Sameer, additional, Meleth, Sreelatha, additional, Earp, Diane, additional, Williams, Rick, additional, Sista, Akhilesh K, additional, Marston, William, additional, Rathbun, Suman, additional, Magnuson, Elizabeth A, additional, Razavi, Mahmood K, additional, Jaff, Michael R, additional, and Kearon, Clive, additional

Published
2016
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39. Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism.

Author

Chiarello, Matthew A. and Sista, Akhilesh K.

Subjects
*HEMORRHAGE risk factors, *HEART ventricle diseases, *CATHETERS, *DISEASES, *RIGHT heart ventricle, *EVALUATION of medical care, *PULMONARY embolism, *THROMBOLYTIC therapy, *SAMPLE size (Statistics), *TREATMENT effectiveness, *DISEASE complications, *EMBOLISM risk factors, RESEARCH evaluation
Abstract

Acute pulmonary embolism (PE) is a leading cause of morbidity and mortality in the United States. PE associated with right ventricular strain, termed submassive or intermediate-risk PE, is associated with an increased rate of clinical deterioration and short-term mortality. Trials have demonstrated systemic thrombolytics may improve patient outcomes, but they carry a risk of major hemorrhage. Catheter-directed thrombolysis (CDT) may offer similar efficacy to and a lower risk of catastrophic hemorrhage than systemic thrombolysis. Three prospective trials have evaluated CDT for submassive PE; ULTIMA, SEATTLE II, and PERFECT. These trials provide evidence that CDT may improve radiographic efficacy endpoints in submassive PE with acceptable rates of major hemorrhage. However, the lack of clinical endpoints, long-term follow-up, and adequate sample size limit their generalizability. Future trials should be adequately powered and controlled so that the short- and long-term effectiveness and safety of CDT can be definitively determined. [ABSTRACT FROM AUTHOR]

Published
2018
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42. Four key questions surrounding thrombolytic therapy for submassive pulmonary embolism.

Author

Sista, Akhilesh K., Horowitz, James M., and Goldhaber, Samuel Z.

Subjects
*PULMONARY embolism, *THROMBOLYTIC therapy, *VASCULAR catheters, *POSTOPERATIVE period, *TREATMENT effectiveness, *THERAPEUTICS
Abstract

Submassive pulmonary embolism (PE) remains a vexing entity, and the appropriate use of thrombolytic therapy for this subgroup continues to be actively debated. Catheter-directed thrombolysis has shown efficacy for submassive PE and is gaining momentum because of theoretically improved safety. This review poses and responds to four questions that explore the complex issues surrounding optimal therapy of submassive PE. [ABSTRACT FROM AUTHOR]

Published
2016
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43. National trends in utilization of thrombolytic therapy for acute pulmonary embolism.

Author

Beyer, Sebastian E, Shanafelt, Colby, Pinto, Duane S, Weinstein, Jeffrey L, Giri, Jay, Sista, Akhilesh K, Yeh, Robert W, Secemsky, Eric A, and Carroll, Brett J

Subjects
THROMBOLYTIC therapy, PULMONARY embolism, ST elevation myocardial infarction
Abstract

Keywords: pulmonary embolism (PE); catheter-directed treatment; thrombolysis EN pulmonary embolism (PE) catheter-directed treatment thrombolysis 75 76 2 02/04/22 20220201 NES 220201 Systemic thrombolysis remains a guideline-recommended treatment for high-risk pulmonary embolism (PE).[1] Although it is associated with improved survival, it is associated with a 9% risk of major bleeding.[1],[2] Catheter-directed thrombolysis (CDT) delivers thrombolytic agents directly into the pulmonary arteries with a lower total dose of thrombolytic and potentially a lower risk of bleeding compared with systemic thrombolysis.[3] Therefore, CDT may be an alternative advanced therapeutic option to systemic thrombolysis. CDT, catheter-directed thrombolysis; PE, pulmonary embolism. Thrombolysis, pulmonary embolism (PE), catheter-directed treatment. [Extracted from the article]

Published
2022
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44. Optical imaging of the peri-tumoral inflammatory response in breast cancer

Author

Sista, Akhilesh K, primary, Knebel, Robert J, additional, Tavri, Sidhartha, additional, Johansson, Magnus, additional, DeNardo, David G, additional, Boddington, Sophie E, additional, Kishore, Sirish A, additional, Ansari, Celina, additional, Reinhart, Verena, additional, Coakley, Fergus V, additional, Coussens, Lisa M, additional, and Daldrup-Link, Heike E, additional

Published
2009
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45. Increased aortic stiffness in the insulin-resistant Zuckerfa/farat

Author

Sista, Akhilesh K., primary, O'Connell, Mary K., additional, Hinohara, Tomoya, additional, Oommen, Santosh S., additional, Fenster, Brett E., additional, Glassford, Alexander J., additional, Schwartz, Eric A., additional, Taylor, Charles A., additional, Reaven, Gerald M., additional, and Tsao, Philip S., additional

Published
2005
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46. Guidance for the use of thrombolytic therapy for the treatment of venous thromboembolism

Author

Vedantham, Suresh, Piazza, Gregory, Sista, Akhilesh K., and Goldenberg, Neil A.

Subjects
Venous thromboembolism, Pulmonary embolism, Thrombolytic therapy, Anticoagulants, Direct oral anticoagulants (DOAC), New oral anticoagulants (NOAC)
Abstract

Patients with venous thromboembolism (VTE) are prone to the development of both short-term and long-term complications that can substantially affect their functional capacity and quality of life. Patients with deep vein thrombosis (DVT) often develop recurrent VTE or the post-thrombotic syndrome, whereas patients with pulmonary embolism (PE) can develop long-term symptoms and functional limitations along a broad spectrum extending to full-blown chronic thromboembolic pulmonary hypertension. Clinicians who care for patients showing severe clinical manifestations of DVT and PE are often faced with challenging decisions concerning whether and how to escalate to more aggressive treatments such as those involving the use of thrombolytic drugs. The purpose of this chapter is to provide guidance on how best to individualize care to these patients.

Published
2016
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48. Multidisciplinary approach to the management of pulmonary embolism patients: the pulmonary embolism response team (PERT).

Author

Root CW, Dudzinski DM, Zakhary B, Friedman OA, Sista AK, and Horowitz JM

Abstract

Pulmonary embolism (PE) is a potentially fatal disease with a broad range of treatment options that spans multiple specialties. The rapid evolution and expansion of novel therapies to treat PE make it a disease process that is well suited to a multidisciplinary approach. In order to facilitate a rapid, robust response to the diagnosis of PE, some hospitals have established multidisciplinary pulmonary embolism response teams (PERTs). The PERT model is based on existing multidisciplinary teams such as heart teams and rapid response teams. A PERT is composed of clinicians from the range of specialties involved in the treatment of PE, including pulmonology critical care, interventional radiology, cardiology, and cardiothoracic surgery among others. A PERT is a 24/7 consult service that is able to provide expert advice on the initial management of PE patients and convene in real time to develop a consensus treatment plan specifically tailored to the needs of a particular patient and consistent with the capabilities of the institution. In this review, we discuss the rationale for establishing a PERT and its potential benefits. We discuss considerations in forming a PERT and present case studies of several PERTs currently in operation at different institutions. We also discuss potential difficulties in forming a PERT and review evidence that has been generated by some of the PERTs that have been in operation the longest., Competing Interests: Disclosure The authors report no conflicts of interest in this work.

Published
2018
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50. Increased aortic stiffness in the insulin-resistant Zucker fa/fa rat.

Author

Sista AK, O'Connell MK, Hinohara T, Oommen SS, Fenster BE, Glassford AJ, Schwartz EA, Taylor CA, Reaven GM, and Tsao PS

Subjects
Animals, Aorta metabolism, Elasticity, Extracellular Matrix Proteins metabolism, Male, Muscle, Smooth, Vascular metabolism, Myocytes, Smooth Muscle metabolism, Obesity metabolism, Rats, Rats, Zucker, Signal Transduction, Tissue Culture Techniques, Transforming Growth Factor beta metabolism, Transforming Growth Factor beta1, Up-Regulation, Aorta physiopathology, Insulin Resistance, Obesity physiopathology
Abstract

Accumulating clinical evidence indicates increased aortic stiffness, an independent risk factor for cardiovascular and all-cause mortality, in type 2 diabetic and glucose-intolerant individuals. The present study sought to determine whether increased mechanical stiffness, an altered extracellular matrix, and a profibrotic gene expression profile could be observed in the aorta of the insulin-resistant Zucker fa/fa rat. Mechanical testing of Zucker fa/fa aortas showed increased vascular stiffness in longitudinal and circumferential directions compared with Zucker lean controls. Unequal elevations in developed strain favoring the longitudinal direction resulted in a loss of anisotropy. Real-time quantitative PCR and immunohistochemistry revealed increased expression of fibronectin and collagen IV alpha 3 in the Zucker fa/fa aorta. In addition, expression of transforming growth factor-beta and several Smad proteins was increased in vessels from insulin-resistant animals. In rat vascular smooth muscle cells, 12-18 h of exposure to insulin (100 nmol/l) enhanced transforming growth factor-beta1 mRNA expression, implicating a role for hyperinsulinemia in vascular stiffness. Thus there is mechanical, structural, and molecular evidence of arteriosclerosis in the Zucker fa/fa rat at the glucose-intolerant, hyperinsulinemic stage.

Published
2005
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