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3. Health care costs and changes in subjective health-related quality of life among Finnish adolescents referred to secondary psychiatric out-patient services: a one-year follow-up study

Author

Rissanen Anne, Roine Risto, Marttunen Mauri, Sintonen Harri, and Lindberg Nina

Subjects
adolescents, adolescent psychiatry, health-related quality of life, secondary health care costs, Psychiatry, RC435-571, Psychology, BF1-990
Abstract

There has been growing interest in economic evidence regarding treatment of mental disorders.

Published
2023
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6. Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 patients, a prospective follow-up study

Author

Tartaglione, Marco, Chiarini, Valentina, Buldini, Virginia, Coniglio, Carlo, Moro, Federico, Orlando, Silvia, Fecarotti, Daniele, Cilloni, Nicola, Giuntoli, Lorenzo, Bellocchio, Angela, Matteo, Emanuele, Pizzilli, Giacinto, Siniscalchi, Antonio, Tartivita, Chiara, Cavalli, Irene, Castelli, Andrea, Marchio, Annalisa, Bacchilega, Igor, Bernabé, Laura, Facondini, Francesca, Morini, Luca, Bissoni, Luca, Viola, Lorenzo, Meconi, Tommaso, Pavoni, Vittorio, Venni, Angelica, Pagni, Aline, Cleta, Patrizia Pompa, Cavagnino, Marco, Guzzo, Alessia, Malfatto, Anna, Adduci, Angelina, Pareschi, Silvia, Bertellini, Elisabetta, Maccieri, Jessica, Marinangeli, Elisa, Racca, Fabrizio, Verri, Marco, Falò, Giulia, Marangoni, Elisabetta, Ottaviani, Irene, Boni, Francesco, Felloni, Giulia, Baccarini, Federico Domenico, Terzitta, Marina, Maitan, Stefano, Tutino, Lorenzo, Senzi, Angelo, Consales, Guglielmo, Becherucci, Filippo, Imbriani, Michele, Orlandi, Paolo, Candini, Silvia, Golfieri, Rita, Ciccarese, Federica, Poerio, Antonio, Muratore, Francesco, Ferrari, Fabio, Mughetti, Martina, Giampalma, Emanuela, Franchini, Loredana, Neziri, Ersenad, Miceli, Marco, Minguzzi, Maria Teresa, Mellini, Lorenzo, Piciucchi, Sara, Monari, Matteo, Valli, Michele, Daniele, Federico, Ferioli, Martina, Nava, Stefano, Lazzari Agli, Luigi Arcangelo, Valentini, Ilaria, Bernardi, Eva, Balbi, Bruno, Contoli, Marco, Padovani, Marianna, Oldani, Stefano, Ravaglia, Claudia, Goti, Patrizio, Gamberini, Lorenzo, Mazzoli, Carlo Alberto, Prediletto, Irene, Sintonen, Harri, Scaramuzzo, Gaetano, Allegri, Davide, Colombo, Davide, Tonetti, Tommaso, Zani, Gianluca, Capozzi, Chiara, Dalpiaz, Giorgia, Agnoletti, Vanni, Cappellini, Iacopo, Melegari, Gabriele, Damiani, Federica, Fusari, Maurizio, Gordini, Giovanni, Laici, Cristiana, Lanza, Maria Concetta, Leo, Mirco, Marudi, Andrea, Papa, Raffaella, Potalivo, Antonella, Montomoli, Jonathan, Taddei, Stefania, Mazzolini, Massimiliano, Ferravante, Anna Filomena, Nicali, Roberta, Ranieri, Vito Marco, Russo, Emanuele, Volta, Carlo Alberto, and Spadaro, Savino

Published
2021
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17. Vaikuttavuuden mittaamisessa on syytä siirtyä tekoihin

Author

Räsänen, Pirjo, Hytönen, Maija Liisa, Pakarinen, Sami, Sintonen, Harri, Blom, Marja, Roine, Risto P., Ryynänen, Olli-Pekka, Maksimow, Anu, HUS Helsinki and Uusimaa Hospital District, Clinicum, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, HUS Heart and Lung Center, Lastentautien yksikkö, Harri Sintonen Research Group, Divisions of Faculty of Pharmacy, Division of Pharmacology and Pharmacotherapy, and Pharmacoeconomics

Subjects
3141 Health care science
Published
2022

18. Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study

Author

Lehtomaki, Kaisa, Stedt, Hanna P., Österlund, Emerik, Muhonen, Timo, Soveri, Leena-Maija, Halonen, Paivi, Salminen, Tapio K., Kononen, Juha, Kallio, Raija, Algars, Annika, Heerva, Eetu, Lamminmaki, Annamarja, Uutela, Aki, Nordin, Arno, Lehto, Juho, Saarto, Tiina, Sintonen, Harri, Kellokumpu-Lehtinen, Pirkko-Liisa, Ristamaki, Raija, Glimelius, Bengt, Isoniemi, Helena, Osterlund, Pia, Lehtomaki, Kaisa, Stedt, Hanna P., Österlund, Emerik, Muhonen, Timo, Soveri, Leena-Maija, Halonen, Paivi, Salminen, Tapio K., Kononen, Juha, Kallio, Raija, Algars, Annika, Heerva, Eetu, Lamminmaki, Annamarja, Uutela, Aki, Nordin, Arno, Lehto, Juho, Saarto, Tiina, Sintonen, Harri, Kellokumpu-Lehtinen, Pirkko-Liisa, Ristamaki, Raija, Glimelius, Bengt, Isoniemi, Helena, and Osterlund, Pia

Abstract

Metastatic colorectal cancer is the second most common cause of cancer death. Long-term survival and cure can be achieved after intensive treatments, including metastasectomy, i.e., the removal of all metastases. We wanted to clarify whether a patient health-related quality of life (HRQoL) was reduced by treatments that aimed to maximise metastasectomy rates, and whether HRQoL of treated patients is comparable to the general population. In a cross-sectional study of 444 patients (1751 questionnaires) in the RAXO-study population, we show that HRQoL of intensively treated patients, sometimes with multiple and multisite metastasectomies-usually combined with systemic therapy-remains at a high level during and after curative treatment and when compared with the general population. Good HRQoL was also seen during non-curative treatment from first- to later-lines, with an impaired HRQoL only at end-of-life. Thus, we should aim at maximising metastasectomies since they give long-term survival and sometimes cure with a high HRQoL. Metastasectomy and/or local ablative therapy in metastatic colorectal cancer (mCRC) patients often provide long-term survival. Health-related quality of life (HRQoL) data in curatively treated mCRC are limited. In the RAXO-study that evaluated repeated resectability, a multi-cross-sectional HRQoL substudy with 15D, EQ-5D-3L, QLQ-C30, and QLQ-CR29 questionnaires was conducted. Mean values of patients in different treatment groups were compared with age- and gender-standardized general Finnish populations. The questionnaire completion rate was 444/477 patients (93%, 1751 questionnaires). Mean HRQoL was 0.89-0.91 with the 15D, 0.85-0.87 with the EQ-5D, 68-80 with the EQ-5D-VAS, and 68-79 for global health status during curative treatment phases, with improvements in the remission phase (disease-free >18 months). In the remission phase, mean EQ-5D and 15D scores were similar to the general population. HRQoL remained stable during first- to later-l

Published
2022
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20. Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study

Author

Lehtomäki, Kaisa, primary, Stedt, Hanna P., additional, Osterlund, Emerik, additional, Muhonen, Timo, additional, Soveri, Leena-Maija, additional, Halonen, Päivi, additional, Salminen, Tapio K., additional, Kononen, Juha, additional, Kallio, Raija, additional, Ålgars, Annika, additional, Heervä, Eetu, additional, Lamminmäki, Annamarja, additional, Uutela, Aki, additional, Nordin, Arno, additional, Lehto, Juho, additional, Saarto, Tiina, additional, Sintonen, Harri, additional, Kellokumpu-Lehtinen, Pirkko-Liisa, additional, Ristamäki, Raija, additional, Glimelius, Bengt, additional, Isoniemi, Helena, additional, and Osterlund, Pia, additional

Published
2022
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21. Terveyshyödyn mittarit valintojen tueksi

Author

Sintonen, Harri, Roine, Risto P., Ryynänen, Olli-Pekka, Blom, Marja, Hytönen, Maija Liisa, Clinicum, Kansanterveystieteen osasto, Lääketieteellinen tiedekunta, Farmasian tiedekunnan osastot, Farmakologian ja lääkehoidon osasto, Pharmacoeconomics, HUS Pää- ja kaulakeskus, and Korva-, nenä- ja kurkkutautien klinikka

Subjects
3141 Terveystiede
Published
2022

22. Vaikuttavuustieto jalostuu havainnollistamalla

Author

Ryynänen, Olli-Pekka, Roine, Risto P., Räsänen, Pirjo, Maksimow, Anu, Sintonen, Harri, Helsingin yliopisto, HUS Helsingin ja Uudenmaan sairaanhoitopiiri, Clinicum, Tutkimusryhmä Harri Sintonen, and Kansanterveystieteen osasto

Subjects
316 Hoitotiede, Treatment Outcome, Data Visualization, Statistics as Topic, Statistical Distributions
Abstract

Terveystaloustiede.

Published
2022

23. Arkivaikuttavuuden arviointi yhdellä mittarilla

Author

Pakarinen, Sami, Tuulonen, Anja, Uusitalo-Järvinen, Hannele, Kankaanpää, Markku, Sintonen, Harri, HUS Helsingin ja Uudenmaan sairaanhoitopiiri, HYKS-sairaanhoitoalue, Clinicum, Tutkimusryhmä Harri Sintonen, Kansanterveystieteen osasto, Helsingin yliopisto, Lääketieteellinen tiedekunta, Tampere University, Silmäkeskuksen vastuualue, Kliininen lääketiede, and Kuntoutuksen ja psykososiaalisen tuen vastuualue

Subjects
Treatment Outcome, 3125 Korva-, nenä- ja kurkkutaudit, silmätaudit, 3142 Kansanterveystiede, ympäristö ja työterveys, Quality of Life, Patient Reported Outcome Measures
Abstract

Terveystaloustiede. Suomessa kehitetty 15D on jo levinnyt laajaan käyttöön. Kokemukset Husista ja Taysista osoittavat sen käyttökelpoiseksi yleisen elämänlaadun mittariksi arkivaikuttavuuden arviointiin.

Published
2022

31. Impact of Comorbid Alcohol Use Disorder on Health-Related Quality of Life Among Patients With Depressive Symptoms

Author

Luoto, Kaisa E., Lindholm, Lars H., Koivukangas, Antti, Lassila, Antero, Sintonen, Harri, Leinonen, Esa, Kampman, Olli, Clinicum, Harri Sintonen Research Group, Department of Public Health, University of Helsinki, HYKS erva, Department of Psychiatry, Tampere University, Clinical Medicine, Department of Adolescent Psychiatry, Seinäjoen keskussairaala VA, and Department of Psychotic Disorders

Subjects
Psychiatry, INVENTORY, alcohol use disorder, CARE, motivational interviewing, Clinical Trial, humanities, 3124 Neurology and psychiatry, PREVALENCE, Psychiatry and Mental health, comorbidity, quality of life, DRINKING, mental disorders, depression, behavioral activation, AUDIT
Abstract

Publisher Copyright: © Copyright © 2021 Luoto, Lindholm, Koivukangas, Lassila, Sintonen, Leinonen and Kampman. Background and Aim: In psychiatric clinical practice, comorbidity of depression and alcohol use disorder (AUD) is common. Both disorders have a negative impact on health-related quality of life (HRQoL) in general population. However, research on the impact of comorbid AUD on HRQoL among clinically depressed patients is limited. The purpose of this study was to explore the impact of a psychosocial treatment intervention on HRQoL for depressive patients in specialized psychiatric care with a special focus on the impact of AUD on HRQoL. Material and Methods: Subjects were 242 patients of the Ostrobothnia Depression Study (ClinicalTrials.gov Identifier NCT02520271). Patients referred to specialized psychiatric care who scored at least 17 points on the Beck Depression Inventory at baseline and who had no psychotic disorders were included in the ODS. The treatment intervention in ODS comprised behavioral activation for all but began with motivational interviewing for those with AUD. HRQoL was assessed regularly during 24-month follow-up by the 15D instrument. In the present study, HRQoL of ODS patients with or without AUD was compared and the factors explaining 15D score analyzed with a linear mixed model. In order to specify the impact of clinical depression on HRQoL during the early phase of treatment intervention, a general population sample of the Finnish Health 2011 Survey was used as an additional reference group. Results: HRQoL improved among all ODS study sample patients regardless of comorbid AUD during the first year of follow-up. During 12–24 months of follow-up the difference between groups was seen as HRQoL continued to improve only among the non-AUD patients. A combination of male gender, anxiety disorder, and AUD was associated with the poorest HRQoL in this sample. In combined sample analyses with the reference group, clinical depression had an impact on HRQoL in short-term follow-up regardless of the treatment intervention. Conclusions: This study suggests that, in terms of improvement in HRQoL, the heterogenous group of depressive patients in specialized psychiatric care can be successfully treated with behavioral activation in combination with motivational interviewing for those with AUD. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02520271. Ostrobothnia Depression Study (ODS). A Naturalistic Follow-up Study on Depression and Related Substance Use Disorders. (2015). Available online at: https://clinicaltrials.gov/ct2/show/NCT02520271.

Published
2021

34. Seasonal Variation in Generic and Disease-Specific Health-Related Quality of Life in Rhinologic Patients in Southern Finland

Author

Ylivuori, Maija, Ruuhela, Reija, Sintonen, Harri, Virkkula, Paula, Roine, Risto P., Hytönen, Maija, Korva-, nenä- ja kurkkutautien klinikka, HUS Head and Neck Center, Clinicum, Harri Sintonen Research Group, Department of Public Health, Faculty of Medicine, and University of Helsinki

Subjects
adult, questionnaire, sinonasal, TRENDS, SLEEP, Article, 3142 Public health care science, environmental and occupational health, Cross-Sectional Studies, 15D, Surveys and Questionnaires, SNOT-22, Chronic Disease, Quality of Life, Humans, Medicine, Prospective Studies, Seasons, PREDICTORS, climate, Finland, PROM
Abstract

Background: Seasonal variation in exacerbations, hospitalisations, and mortality statistics has been reported for some diseases. To our knowledge, however, no published studies exist on the seasonality of health-related quality of life (HRQoL) amongst rhinologic patients. Aims/Objectives: This study, therefore, aimed to investigate the possible seasonal variation in rhinologic patients' HRQoL using the rhinologic disease-specific Sino-Nasal Outcome Test-22 (SNOT-22) and the generic 15D HRQoL instrument. Material and Methods: We enrolled unselected adult rhinologic patients requiring specialist care at the Helsinki University Hospital in this cross-sectional, questionnaire-based prospective study during four seasons: February (winter), May (spring), August (summer), and November (autumn). Patients received SNOT-22 and 15D questionnaires via post. The Finnish Meteorological Institute supplied climate data from these months. Results: SNOT-22 and 15D data were available for 301 and 298 patients, respectively. We found no statistically significant differences (p = 0.948) between the mean monthly 15D scores or mean SNOT-22 scales. Furthermore, the mean SNOT-22 subscales did not differ between the monthly study periods. Conclusions and Significance: Our study shows that seasonality did not impact rhinologic patients' SNOT-22 or 15D HRQoL scores. Thus, these questionnaires can be used for follow-up amongst rhinologic patients regardless of season.

Published
2021

35. Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 patients, a prospective follow-up study

Author

Gamberini, Lorenzo, primary, Mazzoli, Carlo Alberto, additional, Prediletto, Irene, additional, Sintonen, Harri, additional, Scaramuzzo, Gaetano, additional, Allegri, Davide, additional, Colombo, Davide, additional, Tonetti, Tommaso, additional, Zani, Gianluca, additional, Capozzi, Chiara, additional, Dalpiaz, Giorgia, additional, Agnoletti, Vanni, additional, Cappellini, Iacopo, additional, Melegari, Gabriele, additional, Damiani, Federica, additional, Fusari, Maurizio, additional, Gordini, Giovanni, additional, Laici, Cristiana, additional, Lanza, Maria Concetta, additional, Leo, Mirco, additional, Marudi, Andrea, additional, Papa, Raffaella, additional, Potalivo, Antonella, additional, Montomoli, Jonathan, additional, Taddei, Stefania, additional, Mazzolini, Massimiliano, additional, Ferravante, Anna Filomena, additional, Nicali, Roberta, additional, Ranieri, Vito Marco, additional, Russo, Emanuele, additional, Volta, Carlo Alberto, additional, Spadaro, Savino, additional, Tartaglione, Marco, additional, Chiarini, Valentina, additional, Buldini, Virginia, additional, Coniglio, Carlo, additional, Moro, Federico, additional, Orlando, Silvia, additional, Fecarotti, Daniele, additional, Cilloni, Nicola, additional, Giuntoli, Lorenzo, additional, Bellocchio, Angela, additional, Matteo, Emanuele, additional, Pizzilli, Giacinto, additional, Siniscalchi, Antonio, additional, Tartivita, Chiara, additional, Cavalli, Irene, additional, Castelli, Andrea, additional, Marchio, Annalisa, additional, Bacchilega, Igor, additional, Bernabé, Laura, additional, Facondini, Francesca, additional, Morini, Luca, additional, Bissoni, Luca, additional, Viola, Lorenzo, additional, Meconi, Tommaso, additional, Pavoni, Vittorio, additional, Venni, Angelica, additional, Pagni, Aline, additional, Cleta, Patrizia Pompa, additional, Cavagnino, Marco, additional, Guzzo, Alessia, additional, Malfatto, Anna, additional, Adduci, Angelina, additional, Pareschi, Silvia, additional, Bertellini, Elisabetta, additional, Maccieri, Jessica, additional, Marinangeli, Elisa, additional, Racca, Fabrizio, additional, Verri, Marco, additional, Falò, Giulia, additional, Marangoni, Elisabetta, additional, Ottaviani, Irene, additional, Boni, Francesco, additional, Felloni, Giulia, additional, Baccarini, Federico Domenico, additional, Terzitta, Marina, additional, Maitan, Stefano, additional, Tutino, Lorenzo, additional, Senzi, Angelo, additional, Consales, Guglielmo, additional, Becherucci, Filippo, additional, Imbriani, Michele, additional, Orlandi, Paolo, additional, Candini, Silvia, additional, Golfieri, Rita, additional, Ciccarese, Federica, additional, Poerio, Antonio, additional, Muratore, Francesco, additional, Ferrari, Fabio, additional, Mughetti, Martina, additional, Giampalma, Emanuela, additional, Franchini, Loredana, additional, Neziri, Ersenad, additional, Miceli, Marco, additional, Minguzzi, Maria Teresa, additional, Mellini, Lorenzo, additional, Piciucchi, Sara, additional, Monari, Matteo, additional, Valli, Michele, additional, Daniele, Federico, additional, Ferioli, Martina, additional, Nava, Stefano, additional, Lazzari Agli, Luigi Arcangelo, additional, Valentini, Ilaria, additional, Bernardi, Eva, additional, Balbi, Bruno, additional, Contoli, Marco, additional, Padovani, Marianna, additional, Oldani, Stefano, additional, Ravaglia, Claudia, additional, and Goti, Patrizio, additional

Published
2021
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37. Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women. Results from the prospective controlled BREX exercise study

Author

Roine, Eija, primary, Sintonen, Harri, additional, Kellokumpu-Lehtinen, Pirkko-Liisa, additional, Penttinen, Heidi, additional, Utriainen, Meri, additional, Vehmanen, Leena, additional, Huovinen, Riikka, additional, Kautiainen, Hannu, additional, Nikander, Riku, additional, Blomqvist, Carl, additional, Hakamies-Blomqvist, Liisa, additional, and Saarto, Tiina, additional

Published
2021
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47. Rajahyöty ja vaihtoehtoiskustannus - kliinikolle tärkeät peruskäsitteet

Author

Sintonen, Harri, Hytönen, Maija, Clinicum, Tutkimusryhmä Harri Sintonen, Kansanterveystieteen osasto, Lääketieteellinen tiedekunta, HUS Pää- ja kaulakeskus, and Korva-, nenä- ja kurkkutautien klinikka

Subjects
Economics, Medical, 316 Hoitotiede, Health Care Rationing, Cost-Benefit Analysis
Abstract

TERVEYS-taloustiede.

Published
2021

50. Additional file 1 of Patient-reported outcomes in coronary artery disease: the relationship between the standard, disease-specific set by the International Consortium for Health Outcomes Measurement (ICHOM) and the generic health-related quality of life instrument 15D

Author

Lappalainen, Laura, Stenvall, Harriet, Lavikainen, Piia, Miettinen, Heikki, Martikainen, Janne, Sintonen, Harri, Tolppanen, Anna-Maija, Roine, Risto P., and Hartikainen, Juha

Abstract

Additional file 1. Table S1. Baseline clinical characteristics. Table S2. Correlation between the 15D dimension values and instrument scores of instruments scores of Seattle Angina Questionnaire short-form (SAQ-7), SAQ Physical Limitation (SAQ-PL), SAQ Angina Frequency (SAQ-AF), SAQ Quality of Life (SAQ-QL), Rose Dyspnea Scale (RDS), and two-item Patient Health Questionnaire (PHQ-2) at baseline (BL) and at one-year (1yr) follow-up. The moderately high correlations are bolded.

Published
2021
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