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Havana has the highest population and consequently generation of municipal solid wastes (MSW) in Cuba. In Havana, the final deposition method for MSW is mainly landfills. However, in most cases, they exceed their lifetime of operation becoming in reality dumpsites without energy recovery from wastes. In this regard, waste-to-energy is a well-established technology for MSW treatment. The aim of this work was to carry out a techno-economic assessment for a proposed waste-to-energy plant in the city of Havana. A step-wise methodology based on two process analysis tools (i.e., Excel and Aspen Plus models) was used for the technical evaluation. Simulation results are in agreement with data from real plants, showing that it is possible to produce 227.1 GWh of electricity per year, representing 6% of the current demand in Havana. The economic analysis showed the feasibility of the project with a net present value of 35,483,853 USD. Results from the sensitivity analyses show the effect of the economy of scale when changes in low heating value were considered. Finally, a hypothetical best scenario was studied considering the net effect on the average Cuban salary. [ABSTRACT FROM AUTHOR]