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Although numerous studies have investigated temporal integration of the acoustic-reflex threshold (ART), research is lacking on the effect of age on temporal integration of the ART. Therefore the effect of age on temporal integration of the ART was investigated for a broad-band noise (BBN) activator. Subjects consisted of two groups of adults with normal-hearing sensitivity: one group of 20 young adults (ten males and ten females, ages 18-29 years, with a mean age of 24 years) and one group of 20 older adults (ten males and ten females, ages 59-75 years, with a mean age of 67.5 years). Activating stimulus durations were 12, 25, 50, 100, 200, 300, 500, and 1000 ms. Significant main effects for duration and age were obtained. That is, as the duration increased, the acoustic reflex threshold for BBN decreased. The interactions of duration x age group and duration x hearing level were not significant. The result of pair-wise analysis indicated statistically significant differences between the two age groups at durations of 20 ms and longer. The observed age effect on temporal integration of the ART for the BBN activator is interpreted in relation to senescent changes in the auditory system.

The purposes of this investigation were two-fold: 1) to prospectively investigate the effect of prolonged lack of binaural amplification in the unaided ears of adults with bilaterally symmetrical sensorineural hearing impairment (BSSHI) fitted monaurally; and, 2) to prospectively investigate the effects of amplification on speech-recognition performance in the aided ears of monaurally and binaurally fitted subjects. Subjects consisted of 19 monaurally aided adults, 28 binaurally aided adults, and 19 control adults. Both ears of the experimental subjects (binaurally and monaurally aided adults) had BSSHI. The speech measures included the W-22 CID suprathreshold speech-recognition test, nonsense syllable test, and speech-perception-in-noise test. Initial testing was done between 6 and 12 weeks following hearing-aid fitting. Retests were performed approximately 1 year following the initial test. The results revealed that the mean aided minus unaided ear score for the nonsense syllable and W-22 tests increased significantly from the initial test to retest, reflecting a slight improvement in speech performance in the aided ear and a slightly greater decrement in the unaided ear. The findings were interpreted with respect to the theories of auditory deprivation and acclimatization.

Performance on tests of pure-tone thresholds, speech-recognition thresholds, and speech-recognition scores for the two ears of each subject were evaluated in two groups of adults with bilateral hearing losses. One group was composed of individuals fitted with binaural hearing aids, and the other group included persons with monaural hearing aids. Performance prior to the use of hearing aids was compared to performance after 4-5 years of hearing aid use in order to determine whether the unaided ear would show effects of auditory deprivation. There were no differences over time for pure-tone thresholds or speech-recognition thresholds for both ears of both groups. Nevertheless, the results revealed that the speech-recognition difference scores of the binaurally fitted subjects remained stable over time whereas they increased for the monaurally fitted subjects. The findings reveal an auditory deprivation effect for the unfitted ears of the subjects with monaural hearing aids.

This study investigates the controversy regarding the influence of age on the acoustic reflex threshold for broadband noise, 500-, 1000-, 2000-, and 4000-Hz activators between Jerger et al. [Mono. Contemp. Audiol. 1 (1978)] and Jerger [J. Acoust. Soc. Am. 66 (1979)] on the one hand and Silman [J. Acoust. Soc. Am. 66 (1979)] and others on the other. The acoustic reflex thresholds for broadband noise, 500-, 1000-, 2000-, and 4000-Hz activators were evaluated under two measurement conditions. Seventy-two normal-hearing ears were drawn from 72 subjects ranging in age from 20-69 years. The results revealed that age was correlated with the acoustic reflex threshold for BBN activator but not for any of the tonal activators; the correlation was stronger under the 1-dB than under the 5-dB measurement condition. Also, the mean acoustic reflex thresholds for broadband noise activator were essentially similar to those reported by Jerger et al. (1978) but differed from those obtained in this study under the 1-dB measurement condition.

Butirosin (BTN) (P. W. K. Woo, G. L. Coffey, H. W. Dion, S. A. Fusari, and G. D. Senos, U. S. Patent 3,541,078, 1970) is a new aminoglycoside antibiotic notably active against opportunist bacterial species within Pseudomonas, Klebsiella, Enterobacter, Serratia, and Proteus. Numerous comparative tests were carried out with BTN and gentamicin (GTM) in vitro and in experimental infections in mice. BTN was more active in Mueller-Hinton broth than in agar, but its activity was lessened at acid pH or under anaerobiosis, as has been observed with other aminoglycosides. In standard agar diffusion tests, inhibition zones greater than 12 mm around 30-mug BTN disks generally denoted susceptibility, equivalent to minimal inhibitory concentrations [Formula: see text] 25 mug/ml. Cross-resistance between BTN and GTM occurred in a variable manner, with a number of bacterial strains strongly resistant to GTM being moderately susceptible to BTN. In mice, after a single subcutaneous injection, absorption of both antibiotics was rapid, with peak serum levels occurring in 15 min; this was followed by rapid elimination with estimated serum half-lives of about 20 min for each. After peroral administration of high doses in mice, there was no appreciable absorption of BTN. Several tests were carried out to compare BTN and GTM with respect to minimal inhibitory concentrations in vitro, acute subcutaneous median mouse protective doses, peak serum levels at such doses, and the therapeutic ratios derived from acute median protective and lethal doses. Although GTM usually proved to be more potent antibacterially on a weight basis, observations on BTN indicated a superior effectiveness in terms of therapeutic ratios.

The acoustic-reflex thresholds (ART) for multicomponent tonal complexes of varying bandwidth and spectral density were obtained from 20 normal-hearing (air-conduction thresholds less than or equal to 20 dB HL at 250-8000 Hz) young adults ranging in age from 20-30 years and 20 normal-hearing, old subjects ranging in age from 60-71 years. The results revealed that the ART decreased with spectral density, plateauing after seven components in the young group and after five components in the old group; the decrease in the acoustic-reflex threshold as a result of the increase in spectral density was less in the old than in the young group. The bandwidth effect (when bandwidth was plotted in hertz or octaves) on the acoustic-reflex threshold was present in the young adults, but substantially reduced in the elderly, as evidenced by the statistically significant interaction between subject group and signal bandwidth. The spectral density results are discussed in terms of their theoretic implications for the energy summation capacity and frequency resolution of the auditory system. The bandwidth results are discussed in terms of their theoretic implications for the frequency-resolving power of the auditory system.